Cannabinoids & the People

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🍃 BEST OF CANNABINOID SCIENCE 🍃

(most of the phytocannabinoid data is here & most of the endocannabinoid data is in the ‘Canna-Science Archive’ at the bottom)

For Corbus Pharmaceuticals in Massachusetts, they’re focusing on obesity with a CB1 inverse agonist (brake) restricted to the body
https://cannabinoidpipelineinsights.substack.com/p/targeting-the-endocannabinoid-system

For MIRA Pharmaceuticals, they have a CB2 drug (MIRA-55) for chronic inflammatory pain & a CB2/‘biased’ CB1 drug for metabolic health & substance use disorders
https://cannabinoidpipelineinsights.substack.com/p/cannabinoid-r-and-d-chronic-pain

For IGC-Pharma, they are targeting Alzheimer’s disease with a partial CB1 drug
https://cannabinoidpipelineinsights.substack.com/p/agitation-and-alzheimers-brief-look

⚕️ Clinical ⚕️

For autism, data from the UK Medical Cannabis Registry found that the initiation of cannabis-based medicinal products was associated with improvements in anxiety, sleep & health-related quality of life
‘UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Autism Spectrum Disorder’
https://onlinelibrary.wiley.com/doi/pdf/10.1002/npr2.70146

In people with inflammatory bowel disease, a survey found cannabis use associated with the relief of nausea, vomiting, insomnia & joint pain as well as an improved ability to live independently, with 60% saying that cannabis use reduced their opioid consumption & ~90% saying it improved their quality of life
‘Marijuana Use for Symptom Control in Inflammatory Bowel Disease: Patients’ Perceptions and Patterns of Use’
https://karger.com/mca/article-pdf/doi/10.1159/000553354/4558109/000553354.pdf

In young people with epilepsy resistant to treatment, CBD caused 70% of them to have a 50% reduction in seizure frequency
‘Effectiveness and Safety of Cannabis-Based Products for Refractory Epilepsy From Real-World Evidence’
https://www.sciencedirect.com/science/article/pii/S0149291826002183

In people with porphyria (difficulty making the blood component heme), a survey found that ~70% reported cannabis using for symptom management & that there was an association with the use of complementary & alternative medicines
‘Complementary and alternative medicines and cannabis use among individuals with acute intermittent porphyria’
https://www.sciencedirect.com/science/article/pii/S1096719226004865

For elite athletes using cannabinoids, interviews found they used them for pain management, sleep, recovery & mental health but faced systemic barriers related to misinformation, stigma & inconsistent policy guidance (#athletes)
‘Inside the Minds of Professional and Elite Athletes: A Qualitative Exploration of Perspectives on Cannabinoid Use in Contact Sports’
https://journals.sagepub.com/doi/pdf/10.1177/19417381261460194
As someone who joined a gym this week & worked out one time, I completely get what they mean.

In people with spinal cord injuries, a low-dose of 1:1 THC:CBD oil caused no clinical changes to spasticity but did improve patient-rated spasticity outcomes
‘Medical cannabis improved self-reported spasticity rating in patients with chronic spinal cord injury: a placebo-controlled, double-blind, crossover pilot clinical trial’
https://pureportal.strath.ac.uk/en/publications/medical-cannabis-improved-self-reported-spasticity-rating-in-pati/

On the combination of cannabinoids & music, a survey found that most people found it enhanced relaxation, improved mood & increased feelings of connection, while also reporting the substitution of cannabis for pharmaceutical treatments for pain, anxiety & sleep, “with music further amplifying these therapeutic effects” (#music)
‘Evaluating the Combined Effects of Cannabinoids and Music, and Their Interactions in Mood and Emotional Regulation: An Online Survey’
https://journals.sagepub.com/doi/abs/10.1177/25785125261467505

For happiness, a drip tea infused with cannabis was associated with a “statistically significant increase in happiness levels”, as based on the questionnaire Thai Mental Health Indicators (TMHI) (#Thai)
‘Effectiveness of Cannabis Sativa-Infused Drip Tea on Happiness Among Individuals Interested in Medical Cannabis-Based Care: A Quasi-Experimental Study’
https://jhsmr.org/index.php/jhsmr/article/view/1393

For CBG in healthy adults, it was well-tolerated with the main reports being “significant decreases in self-reported ratings of Jittery and Active associated with 50 mg, significant decreases in Calm associated with 100 mg, and increases in Appetite associated with 200 mg of CBG”
‘Safety, Pharmacodynamics, and Pharmacokinetics of Oral Cannabigerol (CBG) in Healthy Adults’
https://www.sciencedirect.com/science/article/abs/pii/S0022356526011845

In people with ADHD, this thesis project found that 80 mg of CBG reduced verbal recall but improved attention & processing speed, with participants reporting lower levels of impulsivity & higher levels of coordination
‘CBG and Attention: A Double-Blind, Randomized, Placebo-Controlled Trial Examining the Effects of Cannabigerol on Indicators of Attention-Deficit/Hyperactivity Disorder’
https://scholarworks.uark.edu/etd/6251/

In women with fibromyalgia, a CBD topical reduced localized pain, improved functional capacity & decreased pain & symptom severity scores (#fibro)
‘CBD-Containing Topical Formulation for Localized Pain in Fibromyalgia: A 12-Week Pilot Feasibility Study’
https://journals.sagepub.com/doi/abs/10.1177/25785125261468882

In people with eczema & psoriasis, a traditional Thai herbal cream containing cannabis & turmeric showed antioxidant & anti-inflammatory effects (#Thai)
‘Phytochemical Characterization, Biological Activities, and Preliminary Clinical and Mechanistic Evaluation of Traditional Thai Herbal Cream Containing Cannabis sativa and Curcuma longa for Eczema and Psoriasis’
https://www.preprints.org/frontend/manuscript/99c551acb797c83103132fe94624732e/download_pub

In the children & youth of Manitoba, Canada, the legalization of cannabis was not associated with an increased number of cannabis-related hospitalizations
‘Cannabis-related hospitalizations before and after the legalization of recreational cannabis among children and youth in Manitoba, Canada’
https://ijpds.org/article/view/3469

For the semi-synthetic cannabinoid THC-O-acetate, a survey on how people are using it
‘THC-O-acetate: understanding consumer experiences with a novel semi-synthetic cannabinoid’
https://www.tandfonline.com/doi/abs/10.1080/14659891.2026.2698553

📑 Reviews 📑

For how THC moves through the system, a review of 9 different models
‘Mind the Gap: Unraveling the Pharmacokinetic Variability of Δ9-Tetrahydrocannabinol (THC)’
https://accp1.onlinelibrary.wiley.com/doi/abs/10.1002/jcph.70233

For complex epilepsies & encephalopathies, a review of CBD found improvement in non-seizure outcomes including cognition, behavior, motor function, sleep & quality of life
‘A systematic review of highly purified cannabidiol in developmental and epileptic encephalopathies and complex treatment-resistant epilepsies: Nonseizure outcomes’
https://www.sciencedirect.com/science/article/abs/pii/S0920121126001439

For post-exercise recovery, a review of 70 studies on CBD found it to be anti-inflammatory, neuroprotective, anxiolytic & painkilling
‘Cannabidiol’s effectiveness in post-exercise recovery: an integrated systematic review’
https://www.revistas.una.ac.cr/index.php/mhsalud/article/view/20144/36711

For neuropathic pain, a review on the mechanisms of cannabinoids & the positive results in human trials
‘Cannabinoids for Neuropathic Pain: A Pharmacological Review of Mechanisms, Clinical Translation, and Future Directions’
https://pubmed.ncbi.nlm.nih.gov/42411099/

For neuropathic pain in the body, this review found the CB2 receptor to be a more likely effective target than the CB1 receptor
‘Cannabinoids in peripheral neuropathic pain: Resolving mechanistic mismatch through CB2-oriented phenotype stratification’
https://www.sciencedirect.com/science/article/abs/pii/S0014299926006126

For kidney injury & repair, a review of targeting the endocannabinoid system
‘Emerging Roles of Cannabinoid Pathways in Renal Injury and Repair’
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1777644/abstract

In adolescent depression, a review on the indirect evidence that exercise’s help for depression occurs via improved anandamide responses, CB1 receptor signaling & neural circuit changes between the prefrontal cortex & the amygdala (an emotional processing center)
‘Exercise-Induced Anandamide–CB1R Signaling and Prefrontal–Amygdala Stress Circuits in Adolescent Depression: A Critical Hypothesis-Driven Narrative Review’
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1915122/abstract

For the CB1 receptor, a review on its central role in regulating stress, sleep, feeding behavior & energy metabolism
‘The CB1 receptor as a convergence hub linking stress, sleep and appetite regulation: An integrative neurobiological model’
https://www.sciencedirect.com/science/article/pii/S0149763426003209

⚠️ Harms ⚠️

In EEG brain scans of people with cannabis use disorder, there was enough signal that cannabis users could be distinguished from controls
‘Prefrontal connectivity alterations and oscillatory dynamics in cannabis use disorder’
https://www.sciencedirect.com/science/article/abs/pii/S0301051126001572
“The results showed that a delta–high gamma and beta–high gamma coupling in the prefrontal regions highly specific to classify the top features of CUD participants when the eyes were open. Signaling adaptive modulation of neural oscillations of cannabis users was relatively stable coupling in both states. In addition, it was found that frontal–parietal and frontal–temporal coherence in CUD participants were linked at heightened levels during eye closure according to functional connectivity analysis.”

In heavy cannabis users, they had significantly higher scores for positive & depressive symptoms of psychosis, with earlier age of use associated with increased psychotic-like experiences & poor functioning
‘Cannabis use patterns and psychotic-like experiences: a cross-sectional study of heavy users, occasional users, and non-users’
https://www.sciencedirect.com/science/article/abs/pii/S0022395626003638

For reports of adverse reactions to cannabis in the Italian system, the most common were neurological/psychosis issues, GI reactions & heart problems
‘Analysis of spontaneous reports of suspected adverse reactions related to medical cannabis from the Italian Phytovigilance System’
https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1002/bcp.70695

For cannabis consumption methods & cannabis use disorder risk in Chilean public health data, people vaping cannabis or using edibles had a higher risk of cannabis use disorder than people smoking
‘Non-smoked cannabis consumption formats and Cannabis Use Disorder severity in an illicit setting: Evidence from Chile, 2020–2024’
https://www.sciencedirect.com/science/article/abs/pii/S0955395926002793

In people with cannabis use disorder, progesterone lessened the cannabis cravings in females but not males
‘Sex differences in stress responding in a randomized, placebo-controlled clinical trial of progesterone in cannabis use disorder’
https://link.springer.com/article/10.1007/s00213-026-07128-2

For cannabis use & psychosis, a meta-analysis found a clear dose-response relationship, with genetic factors strongly amplifying this risk (especially the COMT Val allele)
‘ASSOCIATION BETWEEN CANNABIS USE AND PSYCHOSIS: AN UMBRELLA REVIEW AND METAANALYSIS’
https://www.academicmed.org/Uploads/Volume8Issue3/243_7317_JAMP_Ravi_Bammidi_1372_1382.pdf

In people who had a heart transplant, the cannabis users had higher rates of complications & rejection
‘Cannabis use and Post-Transplant Outcomes in Heart Transplant Recipients: A Propensity-Matched Cohort Study’
https://pubmed.ncbi.nlm.nih.gov/42406563/

In the vascular tissue of young adults, the cannabis users had the first stages of plaque formation in their arteries
‘Cannabis Is Associated With Potentially Proatherogenic Inflammation in Youth’
https://www.ovid.com/jnls/circres/fulltext/10.1161/circresaha.126.328913~cannabis-is-associated-with-potentially-proatherogenic

In a young adult with a heart attack, on a potential link to their chronic cannabis use
‘Extensive coronary thrombosis following cannabis use in a young adult: a case report’
https://link.springer.com/article/10.1186/s12245-026-01275-1

For cannabis-induced psychosis, a review found that cannabis use “eliminates [the] traditional female advantage in psychosis onset timing”
‘Sex-specific vulnerabilities in cannabis-induced psychosis: A scoping review’
https://www.sciencedirect.com/science/article/abs/pii/S1876201826002595

In young adults using cannabis, a review found high-potency cannabis use associated with a greater number & intensity of adverse mental health outcomes including dependence, psychosis & cognitive deficits
‘Influence of cannabis potency on mental health outcomes among adolescents and young adults: scoping review’
https://pubmed.ncbi.nlm.nih.gov/42410915/

For neurodevelopmental outcomes after prenatal cannabinoid exposure, a review found the most consistent associations to be behavioral dysregulation, attention-related difficulties & executive function, but most studies found no significant associations with global cognition, language or motor development
‘Neurodevelopmental outcomes following prenatal cannabinoid exposure: a systematic review’
https://link.springer.com/article/10.1007/s00787-026-03126-z

For prenatal cannabis exposure & infant neurodevelopment, a review of 12 studies found an association with poorer self-regulation & visual processing in two studies while the other 10 found no direct associations except for low-income households having worse NICU scores compared to high-income households
‘Prenatal cannabis exposure and infant neurodevelopment: A scoping review of evidence and methodological gaps’
https://www.sciencedirect.com/science/article/abs/pii/S0378378226001453

In the German Rhine region after partial legalization, there were increases for cannabis-related disorders, especially dependence & cannabis-related psychosis
‘Cannabis-Related Hospitalizations Before and After Partial Legalization: An Analysis From Five Psychiatric Clinics in the Rhine-Ruhr Metropolitan Area’
https://pmc.ncbi.nlm.nih.gov/articles/PMC13353537/

🐁 Preclinical 🐁

For rats taking synthesized CBD, there were no meaningful differences from those taking plant-derived CBD
‘Comparative in vitro safety assessments of synthetized and plant-derived Cannabidiol (CBD), and pharmacokinetics of synthetized CBD: Evidence of similar toxicological profiles and accumulation upon repeated oral administration’
https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2026.1844643/abstract

In a mouse model of Gulf War illness, CBD improved their brain’s immune system, altered energetic states & reshaped the microglia (guardian immune cells of the brain)
‘Cannabidiol reverses neuroimmune priming and microglial exhaustion in aged Gulf War Illness mice’
https://assets-eu.researchsquare.com/files/rs-10072088/v1_covered_c8d3edfa-571a-47c8-a173-a9b69202aef2.pdf?c=1783097394

In a rat model of anorexia due to exercise, THC reduced weight loss & prolonged survival
‘Progressive weight loss is attenuated by THC treatment in rats with activity-based anorexia’
https://www.sciencedirect.com/science/article/abs/pii/S0031938426002313

In a mouse model of neuropathic pain, CBD injections reversed their mechanical sensitivity, lowered inflammatory cytokines & reduced activation of the microglia (guardian immune cells of the brain) via serotonin receptors
‘Spinal 5-HT1A Receptor-Related and Microglial Mechanisms Associated With Intrathecal Cannabidiol-Induced Antinociception in Neuropathic Pain’
https://onlinelibrary.wiley.com/doi/abs/10.1002/ardp.70282

In a mouse model of Alzheimer’s disease, nano-CBD had enhanced transport across the blood-brain barrier & caused anti-inflammatory, antioxidant & neuroprotective effects
‘RGD-functionalized cannabidiol lipid nanoparticles improve brain delivery and alleviate cognitive and metabolic dysfunction via gut-brain axis modulation in an Alzheimer’s disease model’
https://www.sciencedirect.com/science/article/pii/S0753332226007602

In an adolescent rat model of schizophrenia, CBD was associated with beneficial shifts in their gut microbiome while both THC & CBD decreased pro-inflammatory microbes & promoted anti-inflammatory ones
‘THC and CBD Differentially Modulated Gut Microbiota in the Poly I:C Rat Model of Schizophrenia’
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1858604/abstract

In a tissue model of HIV-associated neurocognitive disorders, THC & CBD lowered the neuroinflammation caused by the monocytes (a type of white blood cell)
‘Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) Diminish CD16+ Monocyte-Induced Astrocyte Inflammation, while THC Uniquely Inhibits Monocyte Chemotaxis Independent of HIV Status’
https://link.springer.com/article/10.1007/s11481-026-10300-2

In a rat model of skin wounds, topical cannabis seed oil improved wound closure rates, reduced inflammation & improved proliferation & blood vessel formation markers, perhaps via COX-2, NLRP3, SIRT1 & GSK3β
‘In vivo and in silico wound healing potential of Cannabis Sativa seed oil through inflammation mediators’
https://pubmed.ncbi.nlm.nih.gov/42426779/

In a tissue model of early-stage human immune cell development from stem cells, both CBD & THC accelerated differentiation, especially in B cells
“Both CBD and THC induced loss of CD34 expressing HSPCs in a concentration-dependent manner at several time-points, suggesting accelerated differentiation of HSPCs to downstream progenitors. Interestingly, both CBD and THC elicited a strong increase in CD19+ early B cell populations. With CBD and THC, there was also a trend towards an increase in the percentage of monocytes at early time points, with significant increases at several time points at 10 µM, and an increase in the proportion of megakaryocyte progenitors at later time-points. We also found that monocytes and type 2 classical dendritic cells that developed in presence of CBD had greater phagocytic capacity.”
‘Cannabidiol and Δ9-tetrahydrocannabinol alter human hematopoiesis by enhancing B cell lineage commitment’
https://www.sciencedirect.com/science/article/pii/S0300483X26001447

For bacteria resistant to the antibiotic ciprofloxacin, adding the terpene β-caryophyllene improved antibiotic efficacy as well as skin wound healing via the upregulation of wound-healing-associated genes
‘Restoring ciprofloxacin efficacy via β-caryophyllene synergy for concurrent infection control and tissue regeneration’
https://link.springer.com/article/10.1007/s11274-026-05121-7

🆕 Novel Studies 🆕

(my grab bag section for stuff I haven’t quite seen before)

On the effects of inhaled cannabis on asthma, the revered Dr. Tashkin collected the contradictory data & objected to a recent study that combined smoking & vaping
‘Does Inhaled Marijuana Use Have an Adverse Effect On Asthma?’
https://journal.chestnet.org/article/S0012-3692(26)00442-3/fulltext

For the anti-neuroinflammation effects of β-hydroxybutyrate (BHB - a ketone having a PR moment) in microglia (guardian immune cells of the brain), blocking the CB2 receptor removed or lessened the benefits of BHB
‘Unveiling the role of CB2 receptor in beta-hydroxybutyrate mediated modulation of’ [sic]
https://link.springer.com/article/10.1007/s13105-026-01206-x
Here’s one more sexy molecule who we can add to our list of things that work via the endocannabinoid system.
(In fact, as I sit here processing science late on a Friday night, I realized that I too am something that works via the endocannabinoid system)

📰 US Headlines & Fav Articles 📰

For the dreaded federal hemp THC ban, this Senate approved adding a one-month delay to a major spending bill, but a coalition of 35 attorney generals called on Congress to not reverse the planned recriminalization & a Senator introduced an amendment to strip out the extension provision
https://www.marijuanamoment.net/senate-gives-hemp-thc-products-a-lifeline-by-including-provisions-to-delay-planned-federal-ban-in-new-spending-bill/
https://www.marijuanamoment.net/state-attorneys-general-push-congress-not-to-reverse-course-on-banning-hemp-thc-products/
https://www.marijuanamoment.net/gop-senator-aims-to-keep-hemp-thc-product-ban-on-track-for-november-with-new-amendment/

In the US, major cannabis companies have donated millions to PACs aligned with Trump
https://www.salon.com/2026/07/25/big-cannabis-has-cozied-up-to-the-gop/
“Over the past couple of months, four major marijuana companies - Verano, Curaleaf, Trulieve and Vision Management Services, a subsidiary of Green Thumb Industries - each gave $2.5 million to America First Agriculture Action Inc., a Trump-friendly super PAC. They weren’t alone in their donations. Ascend Wellness and Arboretum Bidco, two additional major cannabis companies, also gave $500,000 and $1 million to the PAC. Trulieve gave another $250,000 to the Republican Jewish Coalition Victory Fund, a pro-Israel super PAC.”

The Federal Aviation Administration plans to pay $200k to the National Academy of Sciences for a “clear, scientifically defensible, and operationally actionable fitness-for-duty standards for pilots and air traffic control specialists”
https://www.marijuanamoment.net/faa-considers-new-marijuana-standards-for-pilots-and-air-traffic-controllers-under-trumps-rescheduling-move/
Oh man. They could have just paid me 200 bucks and save themselves the trouble. Absolutely everybody wants a good clear measure of cannabis intoxication. There would be so much money for whoever solves that problem. And yet the problem has yet to be solved.
The only vaguely related work is the potential of using ratios of metabolites to find out when the person last ingested. But that still is not a measure of intoxication or readiness to perform safety-sensitive occupations.

In Canada, a federal court ordered the Human Rights Commission to reopen a discrimination complaint where a cannabis user said the bank revoked his mortgage for (legally) growing medical cannabis in his home
https://www.westernstandard.news/news/federal-judge-orders-human-rights-commission-to-revisit-marijuana-mortgage-discrimination-case/75362

In Massachusetts, the initiative on rolling back the legalization of cannabis will appear on the ballot
https://www.marijuanamoment.net/massachusetts-officials-reject-challenge-to-anti-marijuana-initiative-signatures-ruling-it-will-appear-on-november-ballot/

In Michigan, the Supreme Court ruled that small amounts of illegal cannabis are no longer enough to justify a warrantless vehicle search
https://www.mlive.com/cannabis/2026/07/michigan-supreme-court-rules-vehicle-searches-based-solely-on-low-level-marijuana-violations-are-illegal.html

Meanwhile, in Maryland, the courts allowed for the police to search cars based on the smell of cannabis if the occupants are underage
https://www.marijuanamoment.net/maryland-court-allows-police-to-search-cars-based-on-smell-of-marijuana-if-occupants-are-underage/

In an Arizona independent living community, senior citizens can now use on-site kiosks to buy cannabis products
https://www.marijuanamoment.net/senior-citizens-can-order-marijuana-on-easy-mode-from-new-kiosk-at-independent-living-community-in-arizona/

An interview of reggae legend Native Wayne by Alex Rogers of ICBC

🌐 International News 🌐

In Colombia, on the President-elect & how he used to defend narcotics traffickers in court & now reinvented himself as a law & order candidate
https://www.nytimes.com/2026/07/25/world/americas/colombia-president-de-la-espriella-trump-us-investigation.html

In Germany, half of the ~900 applications for cannabis cultivation associations were rejected
https://internationalcbc.com/nearly-900-cannabis-cultivation-association-applications-submitted-in-germany/

In Germany, a leading pharmacologist alleges cannabis from Thailand has been “greenwashed” into GMP compliance, usually in Portugal
https://www.cannabiz-africa.com/blog/all-medical-cannabis-imported-from-thailand-into-the-eu-is-greenwashed

In Spain, a draft tobacco law could quietly dismantle the thriving cannabis social club scene
https://businessofcannabis.com/spains-tobacco-crackdown-could-quietly-wipe-out-its-cannabis-clubs/

In Jamaica, the government is reviewing a framework for the religious use of cannabis
https://cannabislaw.report/jamaican-government-reviewing-framework-for-religious-use-of-cannabis/

In the UK, on the barriers to medical cannabis access
‘Barriers to Medical Cannabis in the UK: Human Rights Implications of Criminalization and Inequitable Access’
https://journals.sas.ac.uk/amicus/article/view/5917

In Himachal Pradesh, India, they become the 3^rd state to allow for the legal cultivation of cannabis for medical & scientific purposes
https://www.newindianexpress.com/india/2026/Jul/24/himachal-becomes-third-state-in-india-to-allow-legal-cannabis-cultivation-for-medicinal-scientific-use

For medical cannabis in Brazil, an analysis of lawsuits against the government requesting access found the most frequent conditions were epilepsy, autism & pain
‘Therapeutic indications in lawsuits seeking medical Cannabis in Brazil: a cross-sectional study in light of scientific evidence’
https://pmc.ncbi.nlm.nih.gov/articles/PMC13336621/

In Argentina, Chile & Uruguay, a comparison of presidential opinions on drug policy reform since the 1970s
‘Presidential support for drug policy reform: a comparison of cannabis policies in Argentina, Chile and Uruguay (1973–2015)’
https://www.tandfonline.com/doi/full/10.1080/01436597.2026.2693262

⚖️ Business, Laws & Education ⚖️

For the METRC cannabis tracking tags, a report by Beard Bros found they contain lead & arsenic, suggesting issues with worker safety & as well as disposal
https://beardbrospharms.com/articles/california-forced-cannabis-operators-to-use-millions-of-metrc-tags-now-the-tags-have-reportedly-tested-positive-for-prop-65-chemicals/

For cannabis dispensaries, an analysis of where a dollar goes as it moves upstream & why things land hardest on the growers
https://toddharrison.substack.com/p/where-did-the-money-go-and-why-arent

On the legalities of cannabis interstate commerce by Marc Hauser
https://cannabismusings.substack.com/p/cannabis-musings-july-30-2026

In US states with adult-use cannabis laws, they had reduced rates of personal bankruptcy
‘Recreational marijuana legalization and personal bankruptcy’
https://www.sciencedirect.com/science/article/abs/pii/S1544612326009463

For unlicensed cannabis cultivation in California, the single largest & most consistent predictor of reduced unlicensed cultivation was the presence of licensed farms
‘Patterns and correlates of unlicensed cannabis cultivation in California (USA) following adult-use legalization’
https://www.sciencedirect.com/science/article/pii/S0955395926002641

On the effects of cannabis taxes on consumption, a potency tax reduced consumption of higher-potency products while a price tax reduced consumption of higher-price products, but it also pushed people into the illicit market
‘The Impact of Various Tax Bases and Rates on Cannabis Consumption Among US Adults Who use Recreational Cannabis’
https://onlinelibrary.wiley.com/doi/pdf/10.1002/hec.70129

For building adult-use cannabis markets, a policy playbook from the Niskanen Center
‘A Policy Playbook for Building and Fixing Adult-Use Cannabis Markets’
https://www.niskanencenter.org/wp-content/uploads/2026/07/Improving-Adult-Use-Cannabis-Markets-final-draft.pdf

For cannabis policy, a touchy-feely article on storytelling & the art of noticing unloved others
‘Arts of noticing unloved others: reflections on the importance of methods, meetings, and affect in cannabis policy’
https://journals.sagepub.com/doi/abs/10.1177/14744740261457166

For stakeholders in the hemp supply chain, interviews on their perceived challenges
‘Identifying stakeholder perceptions of barriers in the hemp supply chain: a sentiment analysis approach’
https://www.emerald.com/rjta/article-abstract/doi/10.1108/RJTA-11-2025-0257/1385312/Identifying-stakeholder-perceptions-of-barriers-in

In South Africa, a review of 65 papers on the value pathways for cannabis biomass
‘Cannabis sativa L. biomass valorization as a strategic bioresource for South Africa’s circular bioeconomy: integrating biorefinery pathways and green extraction’
https://link.springer.com/article/10.1007/s13399-026-07177-9

In an analysis of HHC gummies, 10 different cannabinoids & synthetic cannabinoids were found
‘Identification and estimated amounts of five triethylsilylated-cannabinoids in HHC gummies by GC-MS and HPLC-UV analysis’
https://www.sciencedirect.com/science/article/pii/S2665910726000514
“GC-MS analysis identified a total of ten cannabinoids: five parent cannabinoids (9R-HHC, 9S-HHC, Δ8-THC, Δ9-THC, and iso-hexahydrocannabinol) and five cannabinoid triethylsilyl (TES) derivatives that corresponded to each of the parent cannabinoids.”

🚗 Driving 🚗

For driving in those who use cannabis the night before, those above the blood THC cutoff of ≥2 ng/mL had subtle changes to their driving performance, most of which did not reach statistical significance
‘The use of THC cutoff levels in blood and oral fluid for detecting impairment in frequent cannabis users who smoked cannabis the “evening before”’
https://link.springer.com/article/10.1007/s00213-026-07129-1

In rural young adults, a survey found that they used cannabis more frequently & drove under the influence more frequently than urban young adults
‘Rural-urban residence in relation to cannabis use influences and behaviors among a sample of US young adults reporting past-month cannabis use’
https://pubmed.ncbi.nlm.nih.gov/42387866/

🚓 The War on Drugs 🚓

Damning & comprehensive report on the Trump boat strikes as either murder, extrajudicial killings or crimes against humanity: “So what you’re telling us is you need less evidence to kill somebody than you do to hold them.” - Rep. Joaquin Castro (D-Texas)
https://www.wola.org/analysis/killing-spree-extrajudicial-executions-in-the-u-s-boat-strikes-campaign/

The cost of the boat strikes: ~$5B
https://breakingdefense.com/2026/07/the-us-military-campaign-to-stop-drug-trafficking-has-failed-its-time-to-move-on/

Boat strikes hitting Mexican fishermen
https://www.latimes.com/world-nation/story/2026-07-20/us-drone-attacks-mexico-drug-boats

The DEA released a 50^th anniversary book!
https://www.dea.gov/about/history
oh man, I know you can read it free at the link above, but I am sorely tempted by the $50 print copy. If it wouldn’t go towards funding something I’ve spent my entire life trying to dismantle, I would so buy it.
But instead I will mind the history chapters for images to demonstrate how the US War on Drugs is absolutely our Captain Ahab story.

On the EU Drug War, an excellent take on social programs as the true solution with Portugal as both the guide & the warning
https://www.socialeurope.eu/europes-drug-war-punishes-the-poor-and-spares-the-powerful

Mexican cartels moving into Africa by sending chemists there to take advantage of its centrality as well as the local market
https://insightcrime.org/news/mexican-meth-expertise-spreads-to-african-labs/

In Bangladesh, a new law allows for the death penalty in cases of drug crimes committed in cyberspace
https://cannabislaw.report/bangladesh-parliament-passes-law-allowing-death-penalty-for-drug-crimes-in-cyberspace/

In Sri Lanka’s recent Drug War push, thousands of teenagers arrested
https://english.newsfirst.lk/2026/07/31/thousands-of-teens-arrested-in-sri-lanka-s-anti-drug-war

In Lebanon, the influencer “Dr. Food” sentenced to life imprisonment with hard labor for smuggling ~800 kg of hashish in cake packaging
https://cannabislaw.report/lebanese-food-influencer-dr-food-sentenced-to-life-for-smuggling-hashish-out-of-lebanon-in-cake-packaging/

In Indonesia, 3 police officers killed during a drug raid
https://en.antaranews.com/news/422360/nine-arrested-after-officers-killed-in-central-kalimantan-drug-raid
And a military raid seized 5k cannabis plants
https://cannabislaw.report/indonesia-military-seizes-5000-cannabis-plants-in-highland-papua-raid/
And in Jakarta, a pilot arrested with 26 kg of MDMA faces possible execution
https://www.channelnewsasia.com/asia/indonesia-malaysia-airlines-pilot-arrested-drugs-mdma-ecstasy-6290211

In northern India, over a dozen police dismissed due to alleged involvement in narcotics trafficking
https://www.ibtimes.co.in/kathua-cop-sacked-over-drug-smuggling-jk-police-tightens-noose-narco-terror-904450

In Korea, 2 men accused of growing cannabis in underground bunkers after pocketing ~$600k in state agricultural loans
https://cannabislaw.report/korea-two-men-accused-of-growing-cannabis-in-underground-bunker-using-government-grants/

Near the Bahamas, the Coast Guard seized $2.8M of cannabis on a boat
https://www.military.com/coast-guard-seizes-2.8-million-in-marijuana-near-the-bahamas

In Spain, 2 tons of hashish intercepted arriving from Morocco
https://cannabislaw.report/spanish-security-forces-seize-nearly-two-tons-of-hashish-arriving-from-morocco/

In Thailand, 1.6 tons of cannabis seized that was destined for the Netherlands
https://cannabislaw.report/thai-examiner-thai-customs-save-government-further-blushes-with-1-6-tonnes-cannabis-seizure-destined-for-hollands-drug-market/

In Mendocino, California, 173k cannabis plants seized from unlicensed operations
https://cannabislaw.report/173000-illegal-cannabis-plants-26-guns-seized-in-massive-mendocino-county-enforcement-sweep-mcso/

In Nepal, 400+ kilograms of cannabis seized
https://cannabislaw.report/nepal-over-419-kg-of-marijuana-seized-in-sarlahi-two-arrested/

In Australia, a man linked to a criminal syndicate arrested for cannabis & money-laundering to the tune of $17M
https://cannabislaw.report/australia-man-arrested-as-part-of-multi-million-dollar-drug-cannabis-and-money-laundering-investigation/

In Australia, 260 cannabis plants seized at a value of ~$500k
https://cannabislaw.report/australia-nsw-520k-cannabis-seized-following-search-warrant-cessnock/

In New Zealand, the bust of a grow with 150 cannabis plants
https://cannabislaw.report/nz-cannabis-bust-in-ngaruawahia/

In the UK, a cannabis farm above a pub discovered with 150 plants
https://cannabislaw.report/uk-cannabis-farm-discovered-in-rooms-above-pub/

In Nepal, 140 kg of cannabis seized from an orchard
https://cannabislaw.report/nepal-140-kg-marijuana-seized-from-orchard-in-parsa/

In Florida, a man faces federal prison time for intent to distribute 100+ kg of cannabis
https://cannabislaw.report/man-caught-in-florida-with-over-100-kilos-of-marijuana-faces-federal-indictment/

In Syria, border guards seized 40+ kg of hashish & 700k pills of Captagon (a stimulant) incoming from Lebanon
https://cannabislaw.report/syrian-border-guards-seize-over-40-kgs-of-hashish-and-700000-captagon-pills-coming-from-lebanon/

In Saudi Arabia, 2 Yemenis arrested for 27 kg of hashish
https://cannabislaw.report/saudi-two-yemenis-arrested-over-27-kg-of-hashish/

In Sri Lanka, a Canadian arrested with 20+ kg of hashish
https://cannabislaw.report/canadian-national-arrested-at-katunayake-airport-with-hashish-worth-over-rs-200-mn/

In Uzbekistan, 12 kg of hashish oil seized at airport
https://cannabislaw.report/uzbek-authorities-seize-nearly-12-kg-of-hashish-oil-at-airport/

In Macau, a man arrested with 3 kg of cannabis hidden in a suitcase
https://cannabislaw.report/malaysian-national-caught-at-macau-airport-with-3-4-kg-of-cannabis-hidden-in-suitcase/

In Nigeria, a man gets 7 years in prison for advertising cannabis online
https://cannabislaw.report/nigeria-man-gets-seven-year-jail-term-for-advertising-cannabis-online/

In Kuwait, a dentist arrested after trying to sell hashish & other drugs on the Internet
https://cannabislaw.report/kuwaiti-dentist-arrested-for-alleged-drug-trafficking-via-social-media/

In Bali, Indonesia, a drug network run by Russians uncovered with 7.8kg of the synthetic cathinone mephedrone
https://cannabislaw.report/bnn-exposes-russian-drug-network-in-bali/

In Singapore, they are testing a clip-on hair scanner for detecting illegal drugs
https://cannabislaw.report/singapore-central-narcotics-bureau-cnb-investigating-drug-hairscanner-tech/

WoD Research

For the crack epidemic of the 1980s, on how the Black community responded in New York City & Atlanta with demands for more aggressive enforcement while also engaging in community activism
‘”The People vs. Crack”: Drugs, Violence, and the Politics of Order Maintenance’
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/D0ADF329BC0A12802CA6E8FCE3ADB59B/S089803062610061Xa.pdf/people_vs_crack_drugs_violence_and_the_politics_of_order_maintenance.pdf

In Bali, Indonesia, on the police methods for detecting cannabis grows
‘LAW ENFORCEMENT AGAINST THE MODUS OPERANDI OF HYDROPONIC MARIJUANA CULTIVATION IN DENSELY RESIDENTIAL AREAS IN THE JURISDICTION OF THE BALI REGIONAL POLICE’
https://myjournal.or.id/index.php/JLSSH/article/view/611/535

For illicit drug markets, an analysis of how each generation integrates the new technologies
‘Risk actants and the socio-technical evolution of illicit drug markets through time: from payphones to crypto-spatial markets and a nascent dark metaverse’
https://www.emerald.com/dhs/article-abstract/doi/10.1108/DHS-01-2026-0005/1385214/Risk-actants-and-the-socio-technical-evolution-of

🛡️ Harm Reduction News 🛡️

In Minnesota, a good piece of journalism on the power of harm reduction & the current worries about funding with a focus on the organization Harm Reduction Sisters
https://www.minnpost.com/mental-health-addiction/2026/05/harm-reduction-sisters-nonprofit-saves-lives-that-might-not-be-good-enough-duluth-minnesota-pulitzer-story-reach/

In Manitoba, Canada, their only supervised consumption site will fully open this week
https://www.cbc.ca/news/canada/manitoba/supervised-consumption-site-open-aug-11-9.7286865

In Winnipeg, Canada, the demand for naloxone training increases as the drug crisis worsens
https://www.cbc.ca/news/canada/manitoba/naloxone-training-opioid-overdose-drugs-9.7272419

In Minnesota, syringe service programs at risk after state support drying up
https://www.minnpost.com/mental-health-addiction/2026/08/needle-exchange-programs-at-risk-of-closure-as-state-funding-dries-up/

Professional POS Ann Coulter said “we could probably end the country’s drug problem by not saving anyone who overdoses”
https://anncoulter.com/2026/07/23/why-are-we-saving-drug-addicts/

Harm Reduction Research

For indigenous harm reduction approaches in British Columbia, on using the Two-Eyed Seeing approach
‘Indigenizing Harm Reduction: Exploring First Nations community-led wise practices in response to the toxic drug crisis in BC’
https://jps.library.utoronto.ca/index.php/ijih/article/view/47012

In interviews of people who reversed overdoses, on how this becomes normalized & invisible moral labor by people who use drugs
‘The habitus of care: Overdose normalization, reversal expertise, and the invisible moral labor of people who use drugs’
https://www.sciencedirect.com/science/article/abs/pii/S0277953626006362

For community-based harm reduction programs, a review of 78 studies found their scale-up was associated with reduced opioid overdose mortality, lessened HIV & HCV transmission & improved initiation & retention of medications for opioid use disorder
‘Community-Based Harm Reduction Programs for Opioid Use Disorder: A Narrative Systematic Review of Effectiveness, Implementation Barriers, and Policy Implications’
https://www.asidejournals.com/index.php/internal-medicine/article/view/729

🍄 Psychoactives, Psychedelics & Plant Medicines 🍄

A fascinating look at a rediscovered early Catholic document on peyote
https://themicrodose.substack.com/p/a-lost-peyote-document-from-1619

An excellent takedown of the evangelical psychedelic book ‘The Christian’s Guide to Psychedelics’ by the pastor Joe Welker
https://www.psychedeliccandor.org/p/reviewing-the-christians-guide-to

Psychedelics & MDMA

For females with anorexia nervosa, psilocybin caused significant improvements to eating disorder symptoms & motivation to change
‘Psilocybin therapy for adult females with anorexia nervosa: pilot study’
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/1F7A572C32BD84045048704D33112A18/S0007125026106874a.pdf/psilocybin-therapy-for-adult-females-with-anorexia-nervosa-pilot-study.pdf

In people with & without depression taking DMT, it reduced their anxiety, increased their life satisfaction & sustained their improvements in quality of life over the next year
‘Beyond symptom reduction: DMT improves anxiety, life satisfaction, and quality of life in healthy volunteers and patients with depression’
https://journals.sagepub.com/doi/abs/10.1177/02698811261465005

For psychedelics & aging, a review of their potential for longevity science
‘Psychedelics and longevity: implications for lifespan, healthspan and functional aging’
https://www.tandfonline.com/doi/pdf/10.1080/30653495.2026.2696224

A review of psychedelics & the thalamocortical system (a bridge between the cerebral cortex & the thalamus responsible for sensory perception, regulating consciousness, motor control & cognitive functions)
‘Psychedelics and the thalamocortical system: A scoping review’
https://www.sciencedirect.com/science/article/abs/pii/S0091305726000870

On Canadian policy for using psychedelics in palliative care, a review of the trajectory of their drug policy
‘Policy pathways and historical insights: Canada’s evolving approach to psychedelic access for end-of-life distress’
https://www.sciencedirect.com/science/article/pii/S0955395926002665

In a rat model of alcohol use disorder, a single dose of ayahuasca reduced relapse drinking, lowered the anxiety & depression-like behaviors induced by alcohol, lessened oxidative stress across brain regions & restored the levels of BDNF (a key brain growth factor)
‘Single Ayahuasca administration attenuates alcohol relapse and associated behavioral, neurochemical, and oxidative alterations in rats’
https://www.sciencedirect.com/science/article/abs/pii/S0278584626002150

Ketamine

In brain scans of people with major depressive disorder, a ketamine infusion altered cortical dynamics in the responders, potentially being a useful biomarker for predicting antidepressant response to ketamine
‘Ketamine alters the aperiodic EEG exponent in major depression: implications for cortical E/I balance and treatment prediction’
https://journals.sagepub.com/doi/full/10.1177/20451253261462240

In ketamine for a range of mental health conditions, on their disorder-specific changes to their brain scan EEG results
‘Ketamine effects on EEG and their links to therapy differ across treatment-resistant major depression, post-traumatic stress disorder, and obsessive-compulsive disorder’
https://academic.oup.com/ijnp/advance-article/doi/10.1093/ijnp/pyag037/8725363

In ketamine for treatment-resistant depression, on the potential of higher levels of kynurenic acid as a predictor of therapeutic response
‘Kynurenine pathway profiles as markers of ketamine response in treatment-resistant depression’
https://www.sciencedirect.com/science/article/pii/S0889159126006379

In people with treatment-resistant depression, ketamine injections produced short-term clinical benefits
‘Effectiveness and safety of repeat dose subcutaneous ketamine for treatment-resistant depression, and the impact of prior ketamine treatment: open label extension of the KADS study’
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/0995DD957145B888CB118FA878F1A930/S0007125026106928a.pdf/effectiveness-and-safety-of-repeat-dose-subcutaneous-ketamine-for-treatment-resistant-depression-and-the-impact-of-prior-ketamine-treatment-open-label-extension-of-the-kads-study.pdf

A case report of chronic ketamine use associated with progressive multisystem organ dysfunction
‘Chronic ketamine use associated with progressive multisystem organ dysfunction’
https://casereports.bmj.com/content/19/7/e273088.abstract

A case report of ketamine use leading to pain & bladder problems
‘Ketamine-induced cystitis: Lessons from a case of recreational use’
https://www.sciencedirect.com/science/article/pii/S1544319126004711

For cancer-related pain & palliative care, a review of ketamine’s clinical use & safety
‘Ketamine for Cancer-Related Pain in Palliative Care: A Systematic Review of Clinical Use and Safety’
https://www.tandfonline.com/doi/pdf/10.1080/15360288.2026.2700291

In a mouse model of the antidepressant effects of ketamine, on how it changed brain-wide neural dynamics & the microbiome
‘Multilayer brain network analysis in mice reveals ketamine-induced reorganization of brain-wide fluctuations and gut-brain axis’
https://www.nature.com/articles/s42003-026-10606-0

Kratom

For kratom, a survey of why people were using it
‘An Initial Survey Assessing the Temporal Relationship of Kratom Initiation With Medical Treatment and Substance Use’
https://journals.sagepub.com/doi/full/10.1177/29768357261465591

For kratom, a clinical study found stimulant-like benefits with increased energy & focus
‘Observational Real-World Analysis of Dose-Dependent Effects of Mitragyna speciosa (Korth.) on Focus and Energy’
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1838148/abstract

For doctors dealing with kratom, a survey found that the majority felt comfortable discussing its use & over half reported treating problematic kratom use or kratom use disorder
‘Kratom in Clinical Practice: Knowledge, Attitudes, and Screening Behaviors Among U.S.-Based Healthcare Providers’
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2686382

A case report of kratom use leading to a bronze-colored skin rash
‘Photodistributed Hyperpigmentation Associated with Chronic Kratom Use: A Case Report’
https://www.jaad.org/article/S0190-9622(26)01942-0/abstract

🍃 The Plant & its Products 🍃

For hemp seeds, a review of their nutritional composition & utilization as food, medicine & industrial materials
‘Review on Comprehensive Utilization of Hemp Seed with High Quality’
https://www.scirp.net/pdf/ojapps_2313833.pdf

For hemp root extracts, a metabolic analysis & their potential as a food & cosmeceutical (#roots)
‘Health-Promoting Potential of Hemp (Cannabis sativa) Root Extracts: Phytochemical Composition, Biological Activities, and Nutraceutical Applications’
https://www.lidsen.com/journals/rpn/rpn-06-03-012

In cannabis roots, a review of their compounds’ antimicrobial, anti-inflammatory & antioxidant properties as well as interactions with root microorganisms
‘Back to the roots: Cannabis sativa L. root metabolism, microbiomes, and biotechnological potential’
https://link.springer.com/article/10.1007/s00253-026-13955-2

🌱 Growing 🌱

For increasing cannabinoid & terpene production, on the benefits of mechanical stress (a trick of legacy growers)
‘Pre-harvest mechanical stress increases cannabinoid and terpene production in cannabis’
https://link.springer.com/article/10.1186/s12870-026-09309-9

In young cannabis cuttings under salt stress, the bacterial metabolite Bacillin 20 improved germination rates & seedling vigor
‘Bacillin 20 modulates root architecture and germination responses of cannabis under non-saline and saline conditions’
https://www.sciencedirect.com/science/article/pii/S0926669026012379

For analyzing pesticide levels in cannabis, on an automated process using a QuEChERS (Quick, Easy, Cheap, Effective, Rugged & Safe) approach with a GC-MS/MS
‘Automated QuEChERS method for high-throughput analysis of pesticides in Cannabis sativa L. flowering tops by GC-MS/MS’
https://www.sciencedirect.com/science/article/pii/S0003267026008901

In the development of the callus in Moroccan cannabis, on the effects of different mediums & treatments
‘Somatic embryogenesis and histological characterization of callus development in moroccan varieties of Cannabis sativa L.’
https://link.springer.com/article/10.1007/s11240-026-03532-w

For micropropagation of cannabis, a book chapter on strategies
‘In Vitro Mass Propagation of Cannabis sativa L. for Enhanced Production of Anti-aging Metabolites: The Strategic Role of Plant Growth Regulators’
https://link.springer.com/chapter/10.1007/978-981-95-8064-4_12

For feminized hemp seed production, on chemically inducing male flowers on genetically female plants using sequence-characterized amplified region (SCAR) markers
‘Optimized Chemical Masculinization and SCAR Marker-Assisted Screening for Feminized Seed Production in Hemp (Cannabis sativa L.)’
https://onlinelibrary.wiley.com/doi/abs/10.1111/pbr.70111

In early cannabis seed germination under stress conditions, a genetic analysis of the response of the GATA transcription factors (proteins that regulate developmental & stress-response processes)
‘Whole-genome analysis reveals the tandem duplication of Cannabis sativa L. GATA and their stress-responsive expression during seed germination’
https://link.springer.com/content/pdf/10.1186/s12870-026-09308-w_reference.pdf

For cannabis undergoing drought stress, a review of its stress responses
‘Drought Stress in Cannabis sativa L.: Current Knowledge, Research Gaps, and Future Perspectives – A Review’
https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2026.1890092/abstract

For watering cannabis, on creating an automated AI system
‘Automated Dehydration Assessment in Cannabis via YOLOv8 Localization and Multi-Modal Feature Classification’
https://ph01.tci-thaijo.org/index.php/ecticit/article/view/265968

For using drones & AI to monitor your hemp, this field experiment measured the need for nitrogen fertilizer
‘AI-Driven Prediction of Plant Physiological Traits in Hemp Using UAV-Based Multispectral Imagery’
https://www.frontiersin.org/journals/remote-sensing/articles/10.3389/frsen.2026.1843209/abstract

For retting & decortication, an analysis of the effects of roller pressure & moisture
‘PREDICTION OF HEMP FIBER DAMAGE AND DECORTICATION EFFICIENCY USING RANDOM FOREST REGRESSION’
https://smartquillpublishing.uz/storage/articles/pdfs/2026/07/d87c478b-a772-49f7-a096-55d6a674cf80-journal-2026-yil-2-tom-1-son-46-53.pdf

For the water retting of hemp fiber, on using a bacterial bioreactor
‘A prototype bioreactor for the water retting of hemp bast fiber: dynamics of the liquor bacterial consortium across sequential retting cycles’
https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2026.1856675/abstract

🍞 Food & Nutrition 🍞

For insulin resistance, a review of hemp seeds (& flaxseed, chia, pumpkin & sesame)
‘Bioactive components, mechanisms, and applications of functional seeds (Flaxseed, chia, pumpkin, hemp, and sesame) in insulin resistance: A mini-review’
https://www.herbmedpharmacol.com/Article/jhp-53271

A book chapter on hemp for food security
‘Hemp: A Potential Crop for Resilient Food Security’
https://link.springer.com/chapter/10.1007/978-981-92-1471-6_8

On making emulsion gels of soy protein & hemp protein isolate & the effects of salt on gel quality
‘Synergistic effects of ultrasound and Na+ on soy protein isolate–hemp protein isolate–carboxymethyl cellulose composite emulsion gels: Evaluating the potential for low-salt gel foods’
https://www.sciencedirect.com/science/article/abs/pii/S0141813026032757

For extraction from discarded hemp, on using green technologies to extract nutritional components
‘Biorefining hemp processing by-products by supercritical CO2, pressurized liquid, and enzyme-assisted extractions for the recovery of valuable bioproducts’
https://www.sciencedirect.com/science/article/abs/pii/S0960308526001847

For hemp cake as a food waste, it had lower energy recovery potential than flaxseed, but better than cherry pits
‘Energy Potential of Selected Food Waste Samples: A Comparative Analysis of Flaxseed Cakes, Hemp Cake, and Cherry Pits’
http://generalchemistry.chemeng.ntua.gr/uest/kos2026/Proceedings/Session%20XVII/279.KOS2026_Urbancl.pdf

🏗️ Industrial Uses & Fiber 🏗️

For creating antibiotic clothing, on enriching hemp fabric with nanoparticles of platinum & palladium
‘Green Functionalization of Hemp Fabrics with Pd/Pt Nanoparticles via Microwave-assisted Rose Extract Synthesis and Ridge-regularized RSM Optimization’
https://www.nanoient.org/journals/index.php/jent/article/view/3002

For synthetic dye from water, on the adsorption performance of hemp biowaste
‘Comparative Study of the Sorption Mechanism of Reactive Black 5 Dye on Raw and Carbonized Sorbent Derived from Industrial Hemp Biowaste’
https://www.mdpi.com/2079-6412/16/7/808

For clearing the dye methylene blue out of water, on combining hemp waste with potassium carbonate
‘K2CO3-activated carbon derived from industrial hemp waste: characterization and methylene blue adsorption studies’
https://www.tandfonline.com/doi/abs/10.1080/1536383X.2026.2697840

On hemp for biochar, on the effects of chicken manure, vermicompost & wastewater sludge
‘Biochar-Amended Chicken Manure, Vermicompost, And Wastewater Sludge On Hemp Growth, Heavy Metal Accumulation, And Rhizo-Microbial Communities’
https://www.airitilibrary.com/Article/Detail/15606686-N202606120016-00005

For growing, cleaning & separating hemp seeds, on the effects of soil & seed size
‘DETERMINING EFFECT OF GROWING CONDITIONS ON HEMP SEED PROPERTIES’
https://erdev.lbtu.lv/sites/default/files/proceedings/2026/TF064.pdf

On creating electromagnetic interference shielding materials from hemp, sunflower & flax
‘Development of Helianthus annuus waste derived activated biocarbon and Hampa hybrid fibre (hemp 55% and flax 45%) reinforced rigid ester biocomposites for electromagnetic shielding applications’
https://link.springer.com/article/10.1007/s10854-026-17942-1

On upcycling hemp hurds into cellulose nanomaterials
‘Upcycling of Hemp Hurds into High-Value Cellulose Nanomaterials: Nanofibrillated Cellulose and Nanocrystalline Cellulose Production and Characterization’
https://ojs.bioresources.com/index.php/BRJ/article/view/25930

For 3D printed hemp/polylactic acid, on the best printing parameters & testing temperatures for tensile strength
‘Influence of printing parameters and testing temperature on the tensile behaviour of 3D printed hemp/PLA’
https://www.icmams.com/wp-content/uploads/2026/06/paper-136.pdf

For layered epoxy-based composites, reinforcing with hemp & Astragalus fibers
‘Fabrication and characterization of layered epoxy-based composites reinforced with hemp and Astragalus fibers’
https://www.sciencedirect.com/science/article/abs/pii/S2352710226015767

For creating biodegradable green composite materials, on combining woven aloe vera, flax & hemp fiber reinforced with barium sulfate for strength, flexibility & sustainability
‘Mechanical characterization of woven aloe vera/flax/hemp fiber reinforced hybrid green composites with barium sulphate filler’
https://link.springer.com/article/10.1007/s10751-026-02636-1

For creating thermoplastic composites with hemp fiber, on the best ratios for strength & ease of processing
‘Manufacturing-ready hemp fiber–blended composites: extrusion compounding, pelletization, and injection-molding outcomes’
https://www.degruyterbrill.com/document/doi/10.1515/polyeng-2026-0016/html

For hemp shives, 3D characterization of their packing structure
‘3D microstructural characterization of hemp shiv packing using X-ray computed tomography: Morphology and density of hemp shiv particles’
https://enpc.hal.science/hal-05686204/file/preprint_chekai-et-al_2026.pdf

For flattening hemp stems, a study of the best design of flattening rollers
‘STUDY OF FLAT MOVEMENT OF FLATTENING ROLLERS ALONG HEMP STEMS’
https://erdev.lbtu.lv/sites/default/files/proceedings/2026/TF199.pdf

On isolating cellulose & lignin from hemp with green solvents
‘Lignin isolation from hemp pomace and hemp stalk with deep eutectic solvents’
https://www.croris.hr/crosbi/publikacija/prilog-skup/954297

On dissolving hemp-wool blend yarns
‘An investigation into the dissolution of a hemp–wool hybrid yarn by the ionic liquid 1-ethyl-3-methylimidazolium acetate’
https://link.springer.com/article/10.1007/s10853-026-13261-2

For hemp textiles, an analysis of elementary fibers & spinnability
‘COMPREHENSIVE SCIENTIFIC RESEARCH ON NEW VARIETIES OF INDUSTRIAL HEMP FOR MANUFACTURE OF HIGH-QUALITY INDUSTRIAL PRODUCTS’
https://erdev.lbtu.lv/sites/default/files/proceedings/2026/TF006.pdf

For hemp-clay composites, on the best percentages of gum arabic for compressive strength
‘Microstructural mechanisms of gum arabic-stabilized red clay binder for hemp shive building composites’
https://www.sciencedirect.com/science/article/pii/S2352710226016037

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

🏥 Public Health & Bioassays 🏥

For the use of medical cannabis by Queer people in Australia, they started using medical cannabis regularly at an earlier age, were more likely to identify a mental health condition & reported less satisfaction with treatment compared to heterosexuals
‘Patterns, motivations, and healthcare experiences of medical cannabis use among gender and sexuality diverse people in Australia: findings from the Cannabis as Medicine Survey 2022 (CAMS-22)’
https://link.springer.com/article/10.1186/s12954-026-01489-9

For American Indian & Alaska Native adults in the US, those living in medical or adult-use states had higher levels of use
‘Cannabis use patterns among American Indian and Alaska Native adults across U.S. state cannabis policy environments’
https://www.sciencedirect.com/science/article/abs/pii/S0306460326002005

For dentists & dental students, a survey found the majority had favorable opinions towards the therapeutic uses of CBD
‘Medicinal cannabidiol: perceptions of dentists and dental students’
https://www.scielo.br/j/rounesp/a/VD4nKfT4wwXdZPW7Ffq3kbS/abstract/

For the rapid detection of cannabinoids in the blood, a proposed sensor
‘High-performance surface plasmon resonance biosensor design: Encircled quad-block resonator structure for real-time label-free detection of marijuana assisted with linear regression’
https://www.sciencedirect.com/science/article/abs/pii/S1386142526009534

In postmortem blood, on determining the levels of CBN, opioids & nicotine
‘Simultaneous Determination and Method Validation For Opioids, Cannabinol and Nicotine in Postmortem Whole Blood Using High Performance Thin Layer Chromatography Mass Spectrometry’
https://turbanpress.com/subscription/upload_pdf/7-15-ifct-@-1752314419.pdf

🧒 Adolescents & Young Adults 🧒

In young adults after cannabis abstinence, they had gendered changes in higher-level brain processing
‘Network topology and cannabis use following two weeks of monitored abstinence: moderation of sex and patterns of use findings
https://pubmed.ncbi.nlm.nih.gov/41822540/
“Sex moderation was observed; within male cannabis users, higher past-year CU was associated with significantly higher frontoparietal and ventral attention network (VAN) efficiency. Within female cannabis users, higher past-year CU was associated with significantly lower Default Mode Network assortativity. Within individuals who initiated CU before the age of 17, males had lower assortativity in the VAN and Somatomotor network.”

In heterosexual & sexual minority college students, a survey found the sexual minority participants had lower cannabis harm perceptions
‘Explicit and Implicit Cannabis Harm Perceptions in Relation to Cannabis Use Across Sexual Minority and Heterosexual College Students’
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2696907

In adolescent males, problematic cannabis use was the dominant mediator between adversity & delinquency
‘From early adversity to juvenile delinquency: The mediating role of marijuana use, PTSD symptoms and inhibitory control in adolescent males’
https://www.sciencedirect.com/science/article/abs/pii/S0145213426003340

For adolescents in Minnesota, the use of cannabis has declined since 2013
‘Changing cannabis use among diverse adolescents over a 12-year period of policy change: Trends and disparities’
https://www.sciencedirect.com/science/article/abs/pii/S0277953626006738

In university students, cannabis use did not seem to influence their dietary behaviors or meal skipping
‘Cannabis Use and Diet Quality Among University Students: The Role of Meal Skipping and Health Behaviours’
https://pmc.ncbi.nlm.nih.gov/articles/PMC13364245/

In youth with first-episode psychosis, a cannabis harm reduction app was not associated with any robust improvements
‘Correlates of Engagement and Associations with Outcomes in a Cannabis Harm Reduction Mobile App for Youth with First-Episode Psychosis: Exploratory Findings from the CHAMPS Pilot Randomized Controlled Trial’
https://pubmed.ncbi.nlm.nih.gov/42423495/

On the motives for alcohol & cannabis use among young adults, they included fun, sociality & coping
‘Day-level latent classes of alcohol and cannabis use motives: Associations by combined use, level of use, and consequences’
https://psycnet.apa.org/record/2027-95351-001

🧠 The Brain & Neurological Disorders 🧠

In the adolescent mouse striatum (a brain region for movement, reward & habits), a thesis project on visualizing the CB1 receptor & its co-expression with the glycoprotein Reelin (involved in the migration of neurons in the developing brain)
‘Visualizing and Quantifying Cannabinoid Receptor 1 and Reelin Co-Expression in the Adolescent Mouse Striatum’
https://escholarship.org/uc/item/738456wd

In a tissue model of Parkinson’s disease, the phenylpropionamides from hemp seeds caused anti-Parkinsonian effects, potentially via the triggering of autophagy (cellular recycling)
‘Phenylpropionamides of Cannabis sativa L. seeds exert a cytoprotective effect through modulation of the AMPK/mTOR/ULK1 autophagy pathway and attenuate apoptosis in MPP+-induced SH-SY5Y cells’
https://www.sciencedirect.com/science/article/abs/pii/S0040816626004490

In human astrocytes (the brain’s most common support cell), their CB1 receptors were on the cellular membrane & present in the cytoplasm, but not in the mitochondria (powerhouse of the cell)
‘Human cortical astrocytes express type 1 cannabinoid receptor at mRNA and protein levels’
https://europepmc.org/article/ppr/ppr1276976

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

In people with cannabis use disorder, 12 weeks of intense exercise enhanced brain plasticity
‘Exercise-induced brain changes in cannabis use disorder: a longitudinal MRI study of a 12-week supervised HIIT program’
https://www.nature.com/articles/s41380-026-03720-2

For the mental health symptoms of cannabis, a hypothesis paper on one potential link being the disruption of olfactory processing
‘A Hypothesis on the Role of Olfactory Dysfunction in Cannabis-Associated Neuropsychiatric Effects’
https://philarchive.org/rec/PORAHO-2

In people recovering from substance use disorders, a survey of their beliefs about cannabis
‘Cannabis use and beliefs among people in recovery from substance use disorders’
https://link.springer.com/article/10.1186/s42238-026-00461-5

In college students with PTSD, a thesis project on the association & mediation between cannabis use & symptom clusters
‘PTSD Symptoms and Cannabis Use Among College Students: Examining the Role of Trauma-Related Cannabis Use to Cope’
https://www.proquest.com/openview/69161249fbce5c469d34943074d697c7/1

For migraine & co-occurring depression, higher levels of the endocannabinoid 2-AG in the spinal fluid were correlated with depressive symptoms
‘Endocannabinoid cerebrospinal fluid levels in migraine and its relation to symptoms of depression’
https://journals.sagepub.com/doi/full/10.1177/03331024261451250

In the endocannabinoid levels of people with major depressive disorder, this meta-analysis found they had higher levels of anandamide & PEA (but not 2-AG or oleoylethanolamide)
‘Neuroimmune lipidome dysregulation in major depressive disorder: A meta-analysis of peripheral endocannabinoid and N-acylethanolamine signaling’
https://www.sciencedirect.com/science/article/abs/pii/S0889159126006586

In people with non-psychotic mental disorders, a survey found that legalization of adult-use cannabis caused lower concerns about negative legal consequences
‘Attitudes of Patients with Non-Psychotic Mental Disorders Towards Cannabis After Its Legalization—Comparison with Patients Before Legalization’
https://www.mdpi.com/2076-3425/16/7/730

For cannabis use disorder, a review proposing the Social Anxiety - Metacognitive Recovery Disruption (SAMR-D) model
‘The social anxiety–metacognitive recovery disruption (SAMR-D) model: integrating metacognition, motivation, and recovery processes in cannabis use disorder’
https://www.tandfonline.com/doi/abs/10.1080/14659891.2026.2698560

In a mouse model of anxiety, exercise alleviated anxiety-like behaviors via CB1 receptors in the medial prefrontal cortex as well as signaling by GABA (the brain’s primary inhibitory neurotransmitter)
‘Medium-intensity aerobic exercise can relieve mice anxiety by activating cannabinoid type 1 receptors on medial prefrontal cortex GABAergic neurons’
https://www.nature.com/articles/s41398-026-04162-8_reference.pdf

In a newborn rabbit model of classical (Pavlovian) conditioning, the endocannabinoid system was not involved with classical conditioning but was in sensory preconditioning & second-order conditioning as well as a control of memory reconsolidation
‘Double dissociation in the involvement of noradrenergic and endocannabinoid systems in classical and higher-order conditioning in newborn rabbits’
https://www.sciencedirect.com/science/article/abs/pii/S1074742726000602

🧬 Reproduction & Hormones 🧬

In pregnant & postpartum people in the US with HIV, on the demographics of their use of alcohol & cannabis during & after the pregnancy
‘Pregnancy and postpartum cannabis and alcohol use among people with HIV in the United States’
https://obgyn.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pmf2.70350

In a tissue model of prenatal human lung development, co-exposure to tobacco, CBD & THC decreased proliferation, increased DNA damage response markers & induced a senescence-like phenotype
‘Co-exposure to cannabinoids and nicotine increases senescence in prenatal human lung development’
https://www.nature.com/articles/s41390-026-05037-w

In an animal model of prenatal vaped THC & nicotine exposure, the adolescent offspring had altered cognitive effects that were modulated by stress & gender
‘Context-dependent attention and memory outcomes resulting from combined prenatal THC and nicotine exposure following chronic stress’
https://www.sciencedirect.com/science/article/abs/pii/S0091305726000894

In the testes of rats, there was mutual modulation between the endocannabinoid system & the kisspeptin system (a regulator of reproduction & puberty)
‘The Mutual Modulation of Endocannabinoid and Kisspeptin Systems in Rat Testis’
https://www.mdpi.com/2673-396X/7/3/36

🦠 The Immune System & Microbial 🦠

For toxicity in human macrophages (a type of white blood cell) from high levels of lipids, CBD lessened inflammation
‘Cannabidiol selectively attenuates lipotoxic immunometabolic inflammation in human macrophages’
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1873494/full

For the parasite Echinococcus granulosus (hydatid worm, dog tapeworm), a combination of the anti-parasite medication albendazole with the terpene caryophyllene reduced their viability with significant synergy over either treatment alone
‘Synergistic Effects of Combined Caryophyllene and Albendazole against Invaginated and Evaginated Protoscoleces of Echinococcus granulosus’
https://ijpa.tums.ac.ir/index.php/ijpa/article/view/4761

🦴 Pain, Musculoskeletal & Surgeries 🦴

In people with chronic pain & the physicians who treat them, on the stigma around opioid & cannabis use
‘Perceived Prescription Opioid and Medical Cannabis-Related Stigma Among US Adults With and Physicians Who Treat Chronic Pain’
https://pubmed.ncbi.nlm.nih.gov/42420748/

For pain management, a review of nanoencapsulated CBD & THC for better bioavailability
‘Cannabis-Based Nanolipid Formulations for Pain Management’
https://www.mdpi.com/1999-4923/18/7/844

In a mouse & tissue model of muscle atrophy, hemp seed protein hydrolysates positively regulated muscle protein synthesis & degradation
‘Hemp seed protein hydrolysates and its bioactive peptides mitigate muscle atrophy in in vitro and in vivo models’
https://www.sciencedirect.com/science/article/abs/pii/S0963996926017126

❤️ The Heart & Blood ❤️

In atherosclerosis (hardened arteries), human plaques had CB1 receptors & deleting or blocking them lessened the plaque buildup & improved metabolic parameters
‘Endothelial cannabinoid CB1 receptor deficiency reduces shear stress-induced arterial inflammation and lipid uptake’
https://www.nature.com/articles/s41467-026-75214-2

🍽️ The Guts, Nutrition & the Microbiome 🍽️

In people with a high body mass index, this thesis project found that a combination of oleoylethanolamide, ginger & lavender essential oil for 12 weeks did not improve metabolic biomarkers, while reducing white blood cell counts & altering the epigenetics related to metabolism, the immune system & function of the mitochondria (powerhouse of the cell)
‘Metabolic and Epigenetic Impact of Concomitant Fatty Acid Amide Hydrolase Inhibitors and Oleoylethanolamide in a Novel Delivery’
https://scholarship.miami.edu/esploro/outputs/doctoral/Metabolic-and-Epigenetic-Impact-of-Concomitant/991033131430902976

💨 The Lungs 💨

For ingesting CBD as an inhaled dry powder, on using the flavonoid kaempferol for its antioxidant & anti-inflammatory effects as well as for improved aerosolization
‘Incorporating kaempferol into inhalable cannabidiol dry powder enhances stability, aerosolization, and anti-inflammatory effects’
https://www.sciencedirect.com/science/article/abs/pii/S1773224726007215

👀 The Eyes 👀

In a mouse model of retinitis pigmentosa (a rare genetic disorder of the slow breakdown of photoreceptors), inhibition of the enzyme FAAH (which breaks down anandamide) increased photoreceptor cell number & thickness of the retina’s outer nuclear layer as well as a 30% reduction in reactive oxygen species
‘Photoreceptor preservation by FAAH inhibition in a murine model of retinitis pigmentosa’
https://pubmed.ncbi.nlm.nih.gov/42429887/

For cannabinoid receptors in eyes with glaucoma, on the quantum chemistry of THC, CBD & CBN
‘Δ9-THC, CBN, and CBD in Glaucoma: A Theoretical Insight in Light of Molecular Electrostatic Potential and CB1 and CB2 Ligand-Receptor Interaction’
https://www.researchgate.net/publication/408250329_D_9_-THC_CBN_and_CBD_in_Glaucoma_A_Theoretical_Insight_in_Light_of_Molecular_Electrostatic_Potential_and_CB1_and_CB2_Ligand-Receptor_Interaction

🖐️ The Skin & Topicals 🖐️

In people with hidradenitis suppurativa (a skin disease of painful lumps & deep abscesses), an analysis of the endocannabinoid system & pain-sensing network in their skin
‘Compartment-Resolved Transcriptomics of the Cutaneous Endocannabinoid System and Nociceptive Networks in Hidradenitis Suppurativa: Neuro-Immune and Stromal Crosstalk’
https://www.preprints.org/manuscript/202607.0807

In a skin stem cell model of UVB radiation, the combination of CBG & the vitamin C derivative 3-O-ethyl ascorbic acid (EAA) counteracted changes to the membranes, improved antioxidant capacity & caused anti-inflammatory effects
‘Combined Effects of Cannabigerol and 3-O-ethyl Ascorbic Acid on Oxidative
Stress in UVB-irradiated Keratinocytes’
http://vns.microsep.org/wp-content/uploads/2026/07/VNS_2026_Abstract-book_FINAL.pdf#page=46

🎗️ Cancer & Chemotherapy 🎗️

For cancer, a review focusing on cannabis & ferroptosis (a newly discovered type of cell death mediated by iron)
‘Medicinal Cannabis in Cancer Therapy: Targeting Ferroptosis as a Novel and Promising Axis’
https://dergipark.org.tr/en/pub/hujpharm/article/1932122

💊 Synthetic Cannabinoids & Hemp-Derived Cannabinoids 💊

In Turkey, on analyzing the synthetic cannabinoid 5F-MDMB-PINACA (5F-ADB)
‘Quantitative analysis of the synthetic cannabinoid 5F-ADB (5F-MDMB-PINACA) in narcotic substances seized in Türkiye’
https://www.tandfonline.com/doi/abs/10.1080/00450618.2026.2701756

🔬 Biochemical Discoveries & Research Tools 🔬

For peroxisome proliferator-activated receptor gamma (PPARγ - a nuclear receptor that regulates genetic transcription), this molecular docking & dynamics study found that THC, CBD, THCA & CBDA all had at least one stable binding mode
‘Multiple binding modes underlie Cannabis sativa cannabinoids recognition by peroxisome proliferator-activated receptor gamma’
https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2026.1893303/abstract

A proposal for how to convert THC to CBD
‘Synthetic Pathway of Nonpsychoactive Cannabidiol from Psychoactive Tetrahydrocannabinol: A DFT Guide’
https://pubs.acs.org/joceah/article-abstract/91/29/10103/5226288/Synthetic-Pathway-of-Nonpsychoactive-Cannabidiol

On studying anandamide’s cellular effects with a new system using ultraviolet light to cause it to stimulate the CB1 receptor
‘Photorelease of Anandamide at the Cell Plasma Membrane with Optically-Cleavable Targeted Ligands’
https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15005963/v1

Thanks.
- lex

PS: For one of the great voices of jazz, Shirley Horn’s ‘Loads Of Love’ (1963). A great pianist & superior singer, Shirley Horn didn’t find fame until her 50s (in the 1980s), but she was first discovered in 1960 in Washington DC after spending her young life studying music & sneaking into the local jazz clubs. Her first album, ‘Embers and Ash’, came to the attention of Miles Davis & he told the Village Vanguard Jazz Club that he would either perform there with Horn or he would not perform there at all (this was especially notable because Davis was known to not often praise fellow musicians publicly). Those gigs were turned into an album ‘At the Gaslight Square 1961’ & Horn came to the attention of Quincy Jones, then the vice-president Mercury Records, who signed her to the label. Her 2 records with them were well-regarded (a third one was recorded but not released & seems lost to history) but she was more popular with the jazz critics than the wider audience. She resisted efforts to make her into a more popular singer, saying “I will not stoop to conquer”. She semi-retired through the rest of the ‘60s & ‘70s, focusing on raising her daughter.
But in 1978, Steeplechase Records of Denmark tracked her down to make an album & she ended up making 4 with them, leading to engagements across North America & Europe. Then the big break in 1987 when Verve Records pursued her for a contract & she ended up recording 11 studio & live albums for them, these being her most commercially successful productions. Notably, she worked with the same rhythm section for 25 years, Charles Ables on electric bass & Steve Williams on drums. Don Heckman wrote in the Los Angeles Times (February 2, 1995) on “the importance of bassist Charles Ables and drummer Steve Williams to Horn’s sound. Working with boundless subtlety, following her every spontaneous twist and turn, they were the ideal accompanists for a performer who clearly will tolerate nothing less than perfection”.
Shirley Horn performed at the White House for several presidents, received an honorary doctorate from Berklee College of Music as well as the French Academie Du Jazz’s Prix Billie Holiday & was awarded the highest US honor for jazz musicians: the National Endowment for the Arts Jazz Masters Award. A survivor of breast cancer, she passed from diabetes complications at the age of 71.

This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.

Cannabinoids for women in midlife, people who use opioids & anyone who wants to lose weight

Lex Pelger WhiteWhaleCreations — Mon, 20 Jul 2026 08:04:38 GMT

Cannabinoids & The People,
or; Drugs & Drug Wars

🌟 This week 🌟

(#Hashtags for jumping to articles by searching for them with your browser)

For women in midlife, many reported using cannabis to lessen the usage of pharmaceuticals for depression & anxiety
In people using unregulated opioids, they reported cannabis for managing withdrawal symptoms & reducing use
Disturbing accounts of persistent perceptual disturbances from cannabis use (#perceptualproblems)
Breakout sections for prenatal & adolescent harms
For inflammatory acne, a nanogel CBD helped
For a DIY modulator of GLP-1, oleoylethanolamide!
Case reports: CBD for hyperactivity after a TBI + Nabilone for Alzheimer’s
For cannabis & traffic fatalities in the US, probably a few thousand per year (#driving)
Flash: CB1 receptors form heteromer complexes with adenosine receptors. Neurochemists everywhere losing their shit (#heteromers!)
As adolescent comedy movies have taught us, teen mice with submissive personalities become more adventuresome after taking THC while dominant teen mice become more anxious (#teenagedirtbag)
Preclinical: CBD for radiation injury, anxiety, dry eye, Alzheimer’s, intestinal damage, psychosis & neuropathic pain + CBC for arthritis
War on Drugs: both Trump’s boat strikes & his cartel crackdown found to be ineffective and/or counterproductive
Harm Reduction: In Appalachia, law enforcement captured much of the opioid settlement money (#opioidsettlement)
Psychedelics: A secret new source for ibogaine & a researcher with a fascinatingly novel plan (#ibogaine)

[numbers for C&P#194: ~12k words, ~30 minutes reading time, 244 papers]

📌 Editor’s notes 📌:

On TikTok, my cannabinoid education channel has been banned for the last time. If those cowardly chumps don’t want my cannabinoid content, I’ll go where it is wanted: namely YouTube & LinkedIn.
On AI, everybody seems to be releasing how they use it for the sake of transparency. So as someone who has been prepping for this since I read Heinlein’s ‘The Moon is a Harsh Mistress’ at the age of 14 (#iykyk), I’ll jump on board.
Every summary of a scientific paper & piece of prose that you read from me online or in this newsletter was written by me personally. This will not change because I cannot export that cognitive work. I need to have these papers in my brain to do what I do. And to make it useful for you & me, I have to use my taste & experience of doing this for the last 10 years to pick out what’s the most intriguing or novel parts of the study for your reading pleasure & for my archival writeup.
But for my backend, AI has been a game changer. For one, I just finished a Claude-aided reorganization of my canna-science archive & found out that I have 30k hand-annotated papers described with 1.4M words across my 40 knowledge pillar documents (Thanks Mycroft Holmes!). Plus, with these 100 to 200 papers that need sorting each week from this newsletter, being able to tag them for auto-sorting has saved many hours from my workflow of hand-sorting into my archives. And since I have several input streams of new science that tend to overlap each other (Google Scholar Alerts, Pubmed, etc.), building a central database with every paper for deduping has helped me to tackle a backlog of knowledge filing that’s been building up since my 8-year-old was born.
So overall, I use my own brain for reading all the science, but lately, I’ve been relishing the help of AI for keeping it all organized & at my fingertips.
(If you have any questions about the specifics of my workflow, feel free to reach out. It’s been one of the most exciting things in my entire life as a drug writer, and almost nobody I know is even close to fucking interested)

Hello everyone,

Welcome to the 194^th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news + the War on Drugs, harm reduction & other psychoactives. Support this work with a paid subscription or by buying me a coffee. If you purchase one of my canna-graphic novels based on Moby Dick, proceeds go to Americans for Safe Access to support medical cannabis patients.

For producing cannabinoid content, work with my company White Whale Creations: writing, science archives, social media, newsletters & podcasts.

As always, ask me anything!

🤝 Sponsor 🤝: The Cannabis & Health Research Initiative

Want to help expand the knowledge of medical cannabis use in the real world & get paid 100 bucks to do so?

Johns Hopkins University, with support from Realm of Caring, is spearheading the groundbreaking National Cannabis Study to evaluate the benefits, risks & overall outcomes of using cannabis for conditions like pain, insomnia, anxiety & more. If you are an adult in the U.S. considering starting cannabis for health reasons, this is your chance to help shape the future of cannabis research — and get compensated for your time ($100!). Join now to share your experience & contribute valuable data that could revolutionize healthcare for many patients nationwide. To learn more & sign up, visit:
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🎥 Lex’s new work 🎤

@CannabinoidsAndThePeople on YouTube & LinkedIn
Canna-edu videos sponsored by the National Cannabis Study (join & get paid $100 to talk about your use of our favorite plant)

CBD, the EU & Reproductive Toxicity (I spent 2 months researching this short video. It got 12 views. So get ready for the 22 minute version…)
Cannabis & Sleep: The Negatives for Fragile Brains
Vapes Vapes Vapes! For a good solid dry-flower vape device, I’m happy to recommend the Iven from E10 Labs.

Canna-science Videos for CV Sciences on YT @CVSciencesInc & on TT @pluscbd
For 30% off their CBD, THC & PEA products, at pluscbdoil.com use the coupon code ‘LEX’
[videos paused for the summer while I work on a video series about their lovely new PlusHLTH products]

@LexPelgerAndHisBooks on TikTok, YouTube & Instagram:

The Huainanzi & Not Restricting Yourself

And as always, at the bottom is the album of the week: the beautiful blues guitar from the tragic Magic Sam

💖 Ways to support this work 💖

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📣 A request to spread the word 📣

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🍃 BEST OF CANNABINOID SCIENCE 🍃

(Most of the phytocannabinoid data is here & most of the endocannabinoid data is in the ‘Canna-Science Archive’ at the bottom)

LinkedIn post arguing terpenes: a rebuttal to a white paper on the differences between botanical-derived terpenes vs cannabis-derived terpenes (I’m always here for a (respectful) scientific dustup)
https://www.linkedin.com/posts/russhudson_terpenes-limonene-linalool-share-7477697073321058306-DHcZ/
Ross Hudson of the Cannabis Chemistry Collective takes on an industry-white paper from Nexus Agriscience/Terpene Belt Farms claiming that terpenes derived from other botanical sources are not equivalent to terpenes derived from cannabis itself (this is a whole industry debate about the “purity” of adding terpenes to products to match the profiles of favorite cannabis cultivars (strains)). Hudson’s main points touch on the stereochemistry of terpenes & the fact that cannabis cultivars can not be reduced to just terpene profiles when they also contain “esters, aldehydes, ketones, alcohols, volatile sulfur compounds, flavonoids, pigments, sterols, lipids, waxes, oxidation products, degradation products, and trace aroma-active constituents”. Not only do I think that no one is trying to actually replicate all of this complexity, I’m not even sure we can. But overall, this is a great look at what makes cannabis cannabis & what makes science science (and what makes lexical cloning lexical cloning).

For the French pharma company Aelis Farma, they have a drug for cannabis use disorder & another for the cognitive deficits of Down syndrome that causes “signaling-specific inhibition” of the CB1 receptor
https://cannabinoidpipelineinsights.substack.com/p/aelis-farma-endocannabinoid-modulation
Unlike rimonabant, the famous drug that blocks the CB1 receptor for weight loss (but also increases suicidal ideation), this drug apparently aims to selectively block overactivation of the CB1 receptor while leaving healthy CB1 activity intact.

For PleoPharma out of Philadelphia, they are developing a treatment for cannabis use disorder that combines a drug to activate the CB1 receptor as well as modulate GABA (the brain’s most common inhibitory neurotransmitter)
https://cannabinoidpipelineinsights.substack.com/p/cannabinoid-r-and-d-for-cannabis

⚕️ Clinical ⚕️

In people using unregulated opioids, they reported cannabis for managing withdrawal symptoms & that this was significantly associated with self-reported reductions in opioid use
‘Self-reported cannabis use to manage opioid withdrawal symptoms and reductions in opioid use among people who use unregulated opioids: a cross-sectional analysis’
https://link.springer.com/article/10.1186/s42238-026-00458-0

For women in midlife, a survey found that half substituted cannabis for antidepressants & anxiolytic pharmaceuticals, with 2 strong predictors of this being sleep difficulties & alcohol use
‘Substitution of Cannabis for Prescribed Medications in the Management of Anxiety and Depression Among Midlife Women: A Cross-Sectional Study’
https://onlinelibrary.wiley.com/doi/pdf/10.1002/hsr2.72746

In adults aged 55+, having body-based motives for cannabis use was associated with more protective behavioral strategies around cannabis use that reduced the risk for cannabis use disorder, while affective emotion-based motives suggested a higher risk for cannabis use disorder
‘Somatic Motives and Affective Motives are Differentially Associated with Cannabis Protective Behavioral Strategies and Adverse Cannabis Outcomes Among Adults Aged 55 and Older’
https://www.tandfonline.com/doi/abs/10.1080/00332747.2026.2680652

In healthy adults under controlled feeding conditions, oleoylethanolamide (the endocannabinoid of satiation) enhanced the levels of GLP-1 after eating & a statistically significant reduction in meal consumption
‘Acute TRPTI™ (oleoylethanolamide) supplementation enhances incretin hormone responses: a fixed-sequence crossover study’
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1879799/full

In women with breast cancer receiving chemotherapy, cannabis oil lowered their inflammatory cytokines & reduced signals of protein breakdown via the gut microbiome
‘Cannabis Oil and Exploratory Gut–Immune Signatures During Breast Cancer Chemotherapy: A Randomized Pilot Trial’
https://www.mdpi.com/2227-9059/14/6/1367

In people with HIV, the cannabis users had some divergences in their inflammatory profiles as well as modest negatives to their memory performance
‘Neuroimmune Correlates of HIV and Marijuana Use: Peripheral Biomarkers and Cognitive Function’
https://link.springer.com/article/10.1007/s11481-026-10299-6

For people having carpal tunnel surgery, cannabis use or combined with tobacco was associated with increased risk of surgical site infection & wound disruption, while cannabis may be protective against complex regional pain syndrome
‘Impact of cannabis use and tobacco smoking on outcomes of open carpal tunnel release surgery: a nationwide study in the United States’
https://link.springer.com/article/10.1007/s00402-026-06391-4

In people with inflammatory acne, a nanogel-CBD reduced inflammatory lesions by ~50%
‘Cannabidiol-Loaded Hyaluronic Acid-Based Nanogel for Inflammatory Acne: In Vitro and Open-Label, Non-Randomized Clinical Evaluation of Efficacy and Tolerability’
https://www.mdpi.com/2079-9284/13/4/165

In adults with pain from systemic sclerosis (a rare disease of skin tightening & hardening), THC/CBD oil caused a significant reduction in joint pain but no significant effect on overall pain
‘P.289 Cannabis oil in systemic sclerosis: exploratory evaluation of subjective pain outcomes in a placebo-controlled trial’
https://jsrd.bmj.com/content/11/Suppl_1/A284.2

In someone with hyperactivity after a severe traumatic brain injury, a case report of CBD oil markedly reducing hyperactive episode frequency & severity, with his opioid & sedative infusion successfully withdrawn
‘Cannabidiol as an adjunct in refractory paroxysmal sympathetic hyperactivity following severe traumatic brain injury: a case report’
https://link.springer.com/article/10.1186/s13256-026-06284-5

In a person with Alzheimer’s disease, a case report of nabilone (a pharmaceutical cousin to THC) causing significant improvements to agitation & aggression within 2 weeks
‘Case report: use of low dose nabilone to manage BPSD in Alzheimer’s disease’
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/48F3A870195012CCE7EDD49C3576B77F/S205647242611792Xa.pdf/case_report_use_of_low_dose_nabilone_to_manage_bpsd_in_alzheimers_disease.pdf

In proctitis (inflammation of the rectum’s lining), a CBD/sodium propionate enema was associated with less pain, improved patient-reported outcomes & treatment satisfaction
‘Safety And Preliminary Clinical Outcomes Of A Combined Cannabidiol And Sodium Propionate Enema In Refractory Ulcerative Proctitis: An Open-Label Pilot Study’
https://karger.com/iid/article-pdf/doi/10.1159/000552842/4553022/000552842.pdf

For people eating (Turkish) hemp seeds, they had detectable levels of THC metabolites in their urine
‘Low-level urinary cannabinoid findings after controlled administration of hemp seed products in Türkiye: Interpretive value of Δ8-/Δ9-THC-COOH patterns’
https://www.sciencedirect.com/science/article/abs/pii/S0379073826002409

In dogs undergoing mastectomy or hysterectomy, cannabis oil produced sedative effects & reduced anesthetic requirements without clinical complications
‘Sedative and anesthetic-sparing effects of perioperative full-spectrum cannabis oil in female dogs undergoing unilateral mastectomy and ovariohysterectomy’
https://link.springer.com/article/10.1007/s11259-026-11367-1

📑 Reviews 📑

Let’s get meta: In this review of reviews, they analyzed 102 systematic reviews for evidence on the therapeutic uses of cannabinoids
‘Efficacy and Safety of Cannabis Derivates and Their Synthetic Analogs. Overview of Systematic Reviews’
https://onlinelibrary.wiley.com/doi/pdf/10.1002/ptr.70403
“There is low to moderate certainty of evidence of benefits from these interventions for ulcerative colitis, chronic non-cancer pain, Crohn’s disease, multiple sclerosis, and post-chemotherapy nausea and vomiting. The results point to a lack of benefits for sleep disorders, chronic cancer pain refractory to opioids, pain related to radiotherapy, and pain in people receiving palliative care.”

In young people with autism, Rett syndrome (a female-biased genetic disorder of impaired growth, motor skills & language) or fragile X syndrome (a male-biased genetic neurodevelopmental disorder), this review of 17 studies found cannabinoid-based products associated with behavioral improvements & seizure reductions, with mild-to-moderate adverse events & low discontinuation rates
‘Efficacy and Safety of Cannabinoid-Based Products in Children and Adolescents with Autism Spectrum Disorder, Fragile X Syndrome and Rett Syndrome: A Systematic Review’
https://journals.sagepub.com/doi/abs/10.1177/10445463261462382

For CBD & epilepsy, a review of the mechanisms, the clinical trial data & the regulatory aspects
‘Cannabidiol and epilepsy: therapeutic, mechanistic and clinical significance’
https://www.sciencedirect.com/science/article/abs/pii/S105913112600186X

On CBD & blood pressure, this review of 4 trials found that it may reduce blood pressure among healthy & hypertensive people, especially during sleep & under stressful conditions
‘The effects of oral cannabidiol supplementation on blood pressure in adults: a systematic review of randomised controlled trials’
https://link.springer.com/article/10.1186/s42238-026-00463-3

In people with sickle-cell disease, a review of the limited research on cannabinoids
‘Cannabinoid use in adults with sickle cell disease: therapeutic development and clinical insights’
https://www.tandfonline.com/doi/full/10.1080/13543784.2026.2689654

For fibromyalgia, a review of the gendered differences in the expression of endocannabinoid system components & the therapeutic potential of cannabinoids
‘Fibromyalgia, Sexual Dimorphism, and the Endocannabinoid System: An Integrative Review’
https://www.preprints.org/manuscript/202606.1487

For brain scans of using CBD for stress & anxiety, a review of 12 studies found a wide distribution of changes in cortical & subcortical regions, with an overall lack of consistent evidence
‘Functional neuroimaging of Cannabidiol in stress and anxiety: a systematic review’
https://www.frontiersin.org/journals/neuroimaging/articles/10.3389/fnimg.2026.1860919/full

For respiratory diseases, a review on targeting the endocannabinoid system for asthma, pulmonary fibrosis, respiratory syncytial virus infection & acute lung injury
‘Modulation of Respiratory Diseases by the Endocannabinoid System: A Therapeutic Perspective’
https://pubmed.ncbi.nlm.nih.gov/42363690/

In a book on the neurobiology of addiction, the chapter on cannabis
‘Neurobiology of Addiction Series: Volume Five - Cannabis’
https://www.sciencedirect.com/book/monograph/9780128167915/cannabis

For the enzyme MAGL (which breaks down the endocannabinoid 2-AG), a review of its use in animal models related to substance use disorders
‘The Role of Monoacylglycerol Lipase (MAGL) in Substance Use: A Systematic Review of Preclinical Studies’
https://www.sciencedirect.com/science/article/pii/S0006322326013508

For the circuits connecting your pituitary gland to your hypothalamus (regulator of temperature, heart rate, sleep & hunger via hormones), a review of how the endocannabinoids system modulates that relationship
‘Endocannabinoid signalling in the regulation of hypothalamic-pituitary neuroendocrine circuits: A review’
https://reference-global.com/download/article/10.2478/enr-2026-0011.pdf

⚠️ Harms ⚠️

In people with persistent perceptual disturbances from cannabis use, interviews with 13 patients about their visual & auditory symptoms (#perceptualproblems)
‘Cannabis-Induced Persistent Perceptual Disturbances: A Clinical Characterization Study of Multimodal Sensory Symptoms in 13 Patients’
https://www.tandfonline.com/doi/full/10.1080/02791072.2026.2689028
You might have heard of hallucinogen persisting perception disorder (HPPD) where people have long-term sensory symptoms after psychedelic use. But this is the first I’ve ever heard about this happening with cannabis. In just 2 regions of Italy over 5 years, they turned up 13 people with symptoms that would certainly be life-disrupting:
“Visual snow was universal (100%), with high rates of trailing phenomena (92.3%), halos (84.6%), and color changes (76.9%). A novel finding was the presence of auditory hypersensitivity in 61.5% of patients.” 30% of the participants rated their functional impairments as severe.
I love this plant, but it ain’t benign.

For sleep & mental health, a survey of Danish adults found higher levels of anxiety & depression in cannabis users & that those using hash or multiple THC-dominant products had poor sleep quality
‘Beyond cannabis use severity: associations of cannabis product type with sleep quality and mental health’
https://link.springer.com/article/10.1007/s00213-026-07103-x

In chronic cannabis users, brain scans found reduced gray matter volume, thinner insula (a brain region of processing emotions & inner sensations), alterations to the limbic system (emotions) & “lower volumes in the brainstem, left amygdala, right thalamus, left cerebellar cortex, and right orbitofrontal gyrus”
‘Insular Cortical Thinning and Altered Structural Connectivity in Chronic Cannabis Users: A HighResolution Morphometry and Diffusion Tractography Study’
https://assets-eu.researchsquare.com/files/rs-9801898/v1/c41218d6-35e7-4cc2-9677-33b7cf22e15f.pdf?c=1782311005

For cannabis use disorder & early-onset psychosis, a meta-analysis of 40 studies found that cannabis use was associated with less severe negative symptoms & a lower proportion of schizophrenia diagnoses but longer duration of untreated psychosis & higher hospitalization rates
‘Systematic Review and Meta-Analysis: Prevalence, Correlates, and Impact of Cannabis Use and Cannabis Use Disorder in Early-Onset Psychosis’
https://www.sciencedirect.com/science/article/pii/S0890856726002777

In people with psychosis, state-level cannabis commercialization was associated with increased emergency department visits
‘Emergency department use by individuals with and without psychosis after state-level cannabis legalization and commercialization’
https://www.nature.com/articles/s44220-026-00673-x

For the effects of cannabis legalization on opioid overdoses, this thesis project found that adult-use legalization was associated with an increase of 4 synthetic opioid death per 100,000 people
‘Substitute, Gateway, or Neither? The Effect of Recreational Marijuana Legalization on Opioid Outcomes’
https://repositories.lib.utexas.edu/items/5bba5c02-ac69-4354-b192-9a256a6cd4fa

In people with cannabinoid hyperemesis syndrome, they had especially high rates of suicidal thoughts, behaviors & attempts
‘Elevated suicidal thoughts and behaviors, proximal suicide risk factors, and non-suicidal self-injury among adults reporting symptoms of Cannabinoid Hyperemesis Syndrome: Results from a national survey of US adults’
https://pmc.ncbi.nlm.nih.gov/articles/PMC13278203/

In Japan, a case report of a Canadian traveler with potential cannabinoid hyperemesis syndrome
‘Suspected Cannabinoid Hyperemesis Syndrome in a Traveler from a Cannabis-Legal Country: A Case Report from Japan’
https://www.jstage.jst.go.jp/article/ejmj/72/3/72_JMJ26-0010-CR/_pdf

For oral surgery, a case report of cannabis use potentially linked to a hypersensitive pain response & difficulty achieving adequate anesthesia coverage
‘Cannabis-associated hyperalgesia and reduced local anesthetic efficacy in oral surgery: A case report’
https://www.sciencedirect.com/science/article/pii/S2214750026001022

For the hormonal & male fertility effects of cannabis, a review on the muddy animal & human data
‘Disruption of Hormonal and Seminal Parameters by Cannabis Exposure: A Critical Evidence-stratified Review’
https://www.mkjcjournals.in/index.php/jbms/article/view/19

For synthetic cannabinoids, a review of the biomolecular mechanisms behind their toxicity
‘Decoding the Toxicity of Synthetic Cannabinoids: From Receptor Activation to Multiorgan Dysfunction’
https://pubmed.ncbi.nlm.nih.gov/42340025/

For natural killer immune cells (destroyers of infected tissue), cannabis exposure led to dose-dependent toxicity & impaired their killing of other cells
‘Mitochondrial dysfunction and autophagy activation underlie NK cell impairment induced by Cannabis’
https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0350750

Prenatal & Perinatal Harms

For the 41k+ unintentional recreational drug poisonings among US children under 6 since the year 2000, ~85% involved cannabinoids
‘Unintentional ingestion of recreational drugs among young children, 2000–2024’
https://link.springer.com/article/10.1186/s12889-026-28233-z
Yes, pediatric cannabinoid poisonings do not cause death in children, and usually they recover just fine within a few hours, but between the lines of public health data like this, you can see a whole bunch of traumatic experiences. Just like adults can get long-term emotional damage from a bad psychedelic trip, we must imagine the same possibility with a youngster.
And if you forget how strong cannabis edibles can be, I suggest you read the great first Amerikan drug writer Fitz Hugh Ludlow’s ‘The Hasheesh Eater’. His first strong oral cannabis experience was out of this world. And he was a psychologically robust teenager who got it from the pharmacist where he worked. Imagine a trip of that intensity for someone 4-years-old & in a hospital that doesn’t really know how to handle tripping kids?
(makes you long for Huxley’s Island...)

For prenatal tobacco & cannabis use, cannabis legalization with associated increases in cannabis-only use & co-use
‘Associations Between Recreational Cannabis Legalization and Disparities in Prenatal Tobacco and Cannabis Use’
https://academic.oup.com/ntr/advance-article-abstract/doi/10.1093/ntr/ntag138/8711618

In a pregnant mouse model of sickle-cell disease, replacing the treatment drug hydroxyurea with a drug that activates the CB1 receptor significantly reduced the head circumference, brain size, grip strength & eye size of the offspring as well as the weight of the placenta & increased sensitivity to mechanical & cold stimuli
‘In Utero Cannabinoid Exposure Exacerbates Hyperalgesia in Offspring of Sickle Mice’
https://academic.oup.com/jscd/article/3/Supplement_1/yoag020.007/8714165

In zebrafish embryo eye development, prenatal CBD exposure changed the shape of the embryo & the eye
‘Teratogenic effects of cannabidiol exposure on zebrafish embryo eye development’
https://iovs.arvojournals.org/article.aspx?articleid=2814576

In a zebrafish model of prenatal CBD exposure, they appear to have dysregulated vasculature within the eye
‘Identification of hyaloid vasculature phenotypes post cannabidiol exposure’
https://iovs.arvojournals.org/article.aspx?articleid=2814575

In a mouse model of prenatal THC or CBD exposure, increased repetitive behavior in the offspring & the absence of endocannabinoid long-term depression (reduced synaptic strength, an important feature of memory) was a universal feature, while CBD exposure in females caused alterations in risk & in males, changes in brain plasticity
‘Prenatal Cannabidiol and Δ9-Tetrahydrocannabinol exposure lead to sex-specific disruptions in risk assessment and behavioral switching via divergent rewiring of the adult mPFC’
https://amu.hal.science/hal-05667943/file/Caceres%20et%20al%202026%20corrected%20HAL.pdf

In a rat model of prenatal THC exposure, the offspring had reduced respiration capacity in the mitochondria (powerhouse of the cell) as well as regulation of protein homeostasis in the nucleus accumbens (a reward center & regulator of feeding, stress & motivation)
‘Prenatal THC exposure disrupts mitochondrial respiratory gene programs and medium spiny neuron maturation trajectories in the nucleus accumbens’
https://europepmc.org/article/pmc/pmc13142399

In fetal brain cells exposed to prenatal cannabis (extracted from maternal blood), they had altered levels of the CB1 receptor & the D2 dopamine receptor as well as gendered changes to their microRNA (regulators of genetic expression)
‘Prenatal cannabis use is associated with altered miRNA and protein expression in the developing human brain’
https://journals.sagepub.com/doi/full/10.1177/02698811261453833

Adolescent Harms

In young adults with cannabis use disorder, they had a greater risk of developing lower urinary tract symptoms
‘Association Between Cannabis Use Disorder and Lower Urinary Tract Symptoms in Young Adults: A Nationwide Claims Database Study’
https://www.sciencedirect.com/science/article/abs/pii/S0090429526003754

For adolescents with asthma, those using nicotine or cannabis (and especially those using them together) had more intensive emergency department management of their asthma exacerbations & worse short-term outcomes
‘Documented Nicotine, Cannabis, and Co-Use Are Associated With More Intensive Emergency Department Care for Adolescent Asthma Exacerbations’
https://www.sciencedirect.com/science/article/pii/S2688115226001281

In a young adolescent with recurring fevers, a case report of a potential link to cannabis usage
‘PA03 Chronic urticaria associated with systemic symptoms caused by tetrahydrocannabinol use in an adolescent’
https://academic.oup.com/bjd/article/195/Supplement_1/ljag086.435/8718285

In adolescents with psychosis from the synthetic cannabinoid HHC, 2 case reports with individuals requiring 6 weeks of inpatient treatments
‘HHC-induced psychosis in adolescents: a case series’
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/876CDAF240F9F09FF66576C75C59CBFF/S0790966726102018a.pdf/hhcinduced_psychosis_in_adolescents_a_case_series.pdf

For heart attack risk among young adults from cannabis use, a review of the underlying mechanisms
‘Marijuana Use and Acute Myocardial Infarction: Mechanistic Insights, Clinical Implications, and Emerging Challenges’
https://www.sciencedirect.com/science/article/abs/pii/S0002934326004912

🐁 Preclinical 🐁

In a mouse model of adolescent THC exposure, their personality types changed the effects, with submissive mice having increased exploration & reduced anxiety-like behaviors whereas the opposite occurred in dominant mice (#teenagedirtbag)
‘Adolescent Δ9-THC Exposure Differentially Affects Mice Depending on Their Personality’
https://www.mdpi.com/1424-8247/19/7/1009
Now this is fascinating. What a lovely example of preclinical research actually matching to the real world. In teens, it certainly makes gut sense that cannabis could help the anxious be more assertive & the dominant to be more laidback.

In a rat model of radiation injury, CBD-loaded micelles increased body weight recovery, alleviated oxidative stress, conferred multi-organ protection & improved survival rates
‘A γ-radiation-responsive diselenide-core micelle for on-demand delivery of cannabidiol in the mitigation of acute radiation injury’
https://www.sciencedirect.com/science/article/pii/S2590006426006514

In animal models of anxiety & depression, a meta-analysis of 123 studies found CBD caused consistent moderate benefits via changes to the endocannabinoids, serotonin signaling, synaptic plasticity & the mitochondria (powerhouse of the cell)
‘Effects of cannabidiol on anxiety- and depressive-like behaviors and cognition: a systematic review and meta-analysis of preclinical studies’
https://www.nature.com/articles/s41380-026-03733-x

In a mouse model of Alzheimer’s disease, CBD reduced inflammation, oxidative stress & cellular damage from the Aβ plaques, helping to slow progress towards neuronal dysfunction & to preserve synaptic integrity in the hippocampus (a memory center of the brain)
‘Cannabidiol Limits Early Aβ‐Induced Glial Activation and Preserves Synaptic Integrity in Primary Mouse Hippocampal Neuron–Glia Cultures’
https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.70588

In a mouse model of traumatic brain injury, CBD significantly alleviated neuronal injury, cognitive dysfunction & ferroptosis (a newly discovered type of cell death mediated by iron)
‘Cannabidiol alleviates traumatic brain injury-induced neuronal damage and cognitive deficits by inhibiting ferroptosis via the TRPV1/MCU/PI3K/Akt pathway’
https://link.springer.com/article/10.1186/s11658-026-00983-z

In a rat model of rheumatoid arthritis, CBC reduced inflammation & decreased arthritis scores
‘Signaling pathways of inflammation in CIA model of rheumatoid arthritis regulated by cannabichromene’
https://link.springer.com/article/10.1186/s42238-026-00464-2

In a mouse model of psychosis, CBD lessened their hyperlocomotion & pre-pulse intensity (an abrupt stimuli to elicit a startle reflex, a preclinical measure of psychosis)
‘Effects of pimavanserin, xanomeline and highly-purified plant-derived cannabidiol on MK-801-induced behaviours in mice relevant to psychosis’
https://journals.sagepub.com/doi/abs/10.1177/02698811261456216

In a rat model of intestinal damage due to interrupted blood flow, prophylactic treatment with CBD partially reversed pathological alterations & normalized genetic expression markers for inflammation & apoptosis (programmed cellular suicide)
‘Use of Cannabidiol as a prophylactic treatment in acute mesenteric ischemia’
https://assets-eu.researchsquare.com/files/rs-9861553/v1/a4a5df02-94bf-4d69-99b2-459e45dd5ddf.pdf?c=1782472842

In a mouse model of dry eye, CBD increased tearing, likely via negative allosteric modulation of the CB1 receptor
‘Cannabidiol increases basal tearing in a mouse model’
https://iovs.arvojournals.org/article.aspx?articleid=2816154

In a mouse model of neuropathic pain, vaped CBD significantly lessened the pain but also increased inflammation in the lungs
‘Effect of vaporized Cannabidiol (CBD) on neuropathic pain and its potential implication for development of chronic lung inflammation in rats’
https://link.springer.com/article/10.1186/s42238-026-00459-z

In a rat model of reproductive toxicity due to the epilepsy drug valproic acid, a CBD-rich nanoemulsion reversed the hormonal, oxidative & morphological changes
‘CBD-rich oil nanoemulsion mitigates long-term testicular and endocrine toxicity induced by prenatal valproic acid exposure in rats’
https://www.sciencedirect.com/science/article/abs/pii/S0890623826001401

In a mouse model of loss of brain blood flow due to a seizure, vaporized CBD lessened the hypoxia in both genders, while oral THC reduced it in males only, though tolerance eventually developed to some aspects
‘Pharmacological Modulation of Postictal Hypoxia: Sex- and Route-Specific Effects of Acute and Chronic Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC)’
https://ucalgary.scholaris.ca/server/api/core/bitstreams/42cab93a-702f-47e8-a490-5ec1ccb6f4c0/content

In a rat brain tissue model of malformed cortical development (a major cause of difficult-to-treat epilepsies in children), CBD reduced & prevented seizures as well as caused alterations to the genetic expression of the endocannabinoid system
‘Age-dependent effects of cannabidiol on cortical hyperexcitability in an experimental model of malformation of cortical development’
https://www.sciencedirect.com/science/article/pii/S001448862600244X

In a tissue model of neuroinflammation, THC, CBD & the endocannabinoid anandamide lowered inflammation, with anandamide & CBD synergizing their effects while THC & CBD only synergizing at relatively high concentrations
‘Anti-inflammatory effects of single cannabinoids and in combinations’
https://assets-eu.researchsquare.com/files/rs-9759455/v1/6088b2e6-e7dd-4f54-beb6-4e7f165b0428.pdf?c=1782311949

For the entourage effect in the eggs of African clawed frogs (a common model for human diseases), several terpenes increased THC’s activation at the CB1 or CB2 receptor
‘Synergistic and additive terpene-THC interactions in cannabinoid CB1 and CB2 receptors’
https://www.sciencedirect.com/science/article/pii/S0006295226005241
“We found that several terpenes selectively potentiated THC activation at CB₁R and CB₂R. Isobolographic analysis suggested additive THC–terpene interactions for some terpenes, and synergistic interactions for others, including borneol, limonene, sabinene, terpineol, α-pinene and ocimene at CB₁R, and β-caryophyllene and linalool at CB₂R.”

In a rat model of high blood pressure in the lungs, a combination of CBD with the drug Selexipag significantly enhanced cardiac antioxidant capacity & modulation of brain peptide levels, with CBD alone possibly exacerbating the inflammation & structural abnormalities
‘The effects of chronic administration of Cannabidiol and Cannabidiol-Selexipag combination on haematological parameters, oxidative stress, BNP, and TNF-α in a rat model of Pulmonary Arterial Hypertension’
https://pubmed.ncbi.nlm.nih.gov/42348435/

For baby & adult neurogenesis (the growth of new brain cells) in the hippocampus (a memory center of the brain), research in tissue found a crosstalk between receptors for the cannabinoids & adenosine (a neurotransmitter of inhibition), with the novel finding that the CB1 receptor & the A2A receptor formed heteromers (joined receptors that function differently than either receptor alone) (#heteromers!)
‘Cannabinoid and adenosine A2A receptor crosstalk regulates postnatal and adult hippocampal neurogenesis’
https://pubmed.ncbi.nlm.nih.gov/42324982/

In a rat model of liver toxicity due to lead acetate, the terpene beta-caryophyllene reduced oxidative stress, the inflammatory response & the regulation of apoptosis (programmed cellular suicide)
‘β-caryophyllene attenuates lead acetate-induced hepatotoxicity through regulation of oxidative stress, inflammation, and PI3K/AKT/mTOR signaling’
https://link.springer.com/article/10.1007/s00210-026-05605-1

On sodium channels (a key target in epilepsy), CBDA reduced their electrical currents & stabilized the channels’ inactivated state, with CBDA-rich extracts producing stronger inhibitory effects
‘Cannabidiolic acid (CBDA) and CBDA-rich extracts modulatory effects on voltage-dependent NaV1.2 sodium channels’
https://www.sciencedirect.com/science/article/abs/pii/S0944711326007221

In a rat model of developing epilepsy after a brain injury, CBD did not improve their susceptibility to seizure development
‘Subchronic Cannabidiol (CBD) Treatment During the Silent Period Fails to Prevent the Increased Seizure Susceptibility Following Lithium Pilocarpine-Induced Status Epilepticus’
https://www.preprints.org/manuscript/202606.2067

In a mouse model of disturbed sleep due to caffeine, the combination of CBD & L-theanine reduced sleep onset latency & increased total sleep duration, with increases to the levels of serotonin, melatonin & GABA (the brain’s most common inhibitory neurotransmitter)
‘Combined Administration of Cannabidiol and L-Theanine Improves Sleep-Related Outcomes in Caffeine-Induced Sleep Disturbances Mouse Model’
https://www.biomolther.org/journal/view.html?uid=1748&vmd=Full

For dental enamel, a CBD mouthwash lessened the formation of biofilms (slimy aggregations of bacteria that resist treatment)
‘Effect of a cannabidiol-based mouthwash on dental enamel properties and biofilm control: an in situ study’
https://link.springer.com/article/10.1007/s00784-026-06985-7

For combining CBD & piperine (an alkaloid of black pepper), administering them together in mice doubled the CBD exposure
‘Effect of Piperine Codelivery on the Oral Bioavailability of Cannabidiol: Insights from In Vitro Digestion and In Vivo Pharmacokinetics’
https://pubs.acs.org/doi/full/10.1021/acs.jafc.6c02678

🆕 Novel Studies 🆕

(My grab bag section for stuff I haven’t quite seen before)

For the challenges of collecting aerosols from vapes for analyzing heavy metal concentrations, a white paper analyzing several approaches
‘Procedural Challenges in the Analysis of Toxic Metals in Electronic Cannabinoid Delivery System Aerosols Produced for Vaping Cannabinoids’
https://dl.astm.org/jte/article/doi/10.1520/JTE20250320/32379

For the religious aspects of cannabis in South Africa, a review of its ancient uses & on the introduction of cannabis to southern Africa
‘Cannabis Sativa, religion and society: Historical, medicinal, legal, and sacramental perspectives’
https://journals.ufs.ac.za/index.php/at/article/view/8400

📰 US Headlines & Fav Articles 📰

According to Quest Diagnostics, 20% of US workers had a positive hair drug test last year, with the greatest increase being in cannabis
https://www.prnewswire.com/news-releases/one-in-five-american-workers-tested-had-a-positive-hair-drug-test-in-2025-signaling-persistent-long-term-substance-use-patterns-302822819.html

The US National Institute of Standards & Technology (NIST) released a report guiding state regulators on how to best use cannabis scales
https://www.nist.gov/publications/nist-sp-2200-08-suitability-cannabis-scales-2026-ed

In Guam, the first cannabis cultivation license approved a mere 7 years after they legalized adult-use cannabis
https://elplanteo.com/guam-primera-licencia-comercial-cannabis/

In Wyoming, the Attorney General said that federal cannabis rescheduling will not apply in their state (one of the very few states left to not even have medical cannabis)
https://mjbizdaily.com/news/this-state-just-opted-out-of-federal-marijuana-rescheduling/616823/

In Michigan, the Supreme Court ruled that courts can no longer use US federal law to ban someone from using cannabis as a condition of their probation
https://eu.freep.com/story/news/politics/2026/07/07/cannabis-cant-be-banned-as-probation-condition/90826062007/
However, the court refused to weigh in on whether the state’s trial courts had the authority to ban cannabis use while on probation. They only said you couldn’t do so because of federal law.
Overall, it’s a fascinating question, because judges are often allowed to ban the use of alcohol by people on probation. But what about for drugs like cannabis or opioids where they can be both a medicine as well as a substance that can cause damage to their community?

In San Francisco, the Board of Supervisors approved the creation of cannabis cafés
https://www.sfexaminer.com/news/community/board-of-supervisors-approves-creation-of-sf-cannabis-cafes/article_099fed86-3445-4b6b-92c6-3f0a52667d4f.html

For women with ADHD and/or autism, a great piece of science writing from Mia the Neurospicy Nerd
https://renegademia.substack.com/p/adhd-womanhood-and-weed

A great article on being a papa & trying to do too much & leaning on the cannabis too heavily
https://www.fatnugsmag.com/cannabis-and-fatherhood-with-seibo-shen/
Alright. Fine. I’ll take a tolerance break this week while the kids are with their grandparents in the mountains.
Here come the nightmares…

Ali G attended Wimbledon & tried to sell weed to everybody
https://variety.com/2026/film/global/sacha-baron-cohen-ali-g-wimbledon-tries-selling-weed-1236809387/

This new book on cannabis in British India looks amazing & somehow, the author generously published it under an Open Access monograph publishing program
‘Ganja Matters: Empire and the Pursuits of Cannabis in British India’
https://www.jstor.org/content/pdf/oa_book_monograph/jj.44031234
I especially like the 2 epigraphs. Here’s one:
Kiya cheej banaiya khoda / god, what a thing you made!
Bangla desh ka ganja / the ganja of bangla desh!
Ek chilim me jaycha taycha / so-so after one pipe,
Do chilim me moja / but jolly after two,
Teen chilim me wajir najir / a third makes one minister and nobleman
Chaar chilim me raja / the fourth makes one a king.
Kiya cheej banaiya khoda / god, what a thing you made!
Bangla desh ka ganja / the ganja of bangla desh!
- Ganja workers’ song, 1970

🌐 International News 🌐

In Saudi Arabia, they approved their first CBD oral food supplement (though they are still executing people for other cannabinoids. See below)
https://businessplus.ie/news/chanelle-mccoy-health-cbd/

In Kenya, the (apparently incorrectly named) High Court dismissed a bid by Rastafarians to legalize cannabis for religious purposes
https://www.bbc.com/news/articles/c0lyl5ryyr4o

In Lebanon, a Chinese investment of $10M into the medical cannabis sector
https://elplanteo.com/china-invierte-cannabis-libano/

In the Hmong communities of northern Thailand, on the cultural heritage of hemp & interviews about current policy
‘From Cultural Heritage to Emerging Economic Crop: State Agricultural Policy and Local Hemp Development in Khiri Rat Subdistrict, Phop Phra District, Tak Province, Thailand’
https://so04.tci-thaijo.org/index.php/TSDJ/article/view/283337

In South Africa, on the Indigenous knowledge on the cultivation & uses of cannabis
‘Exploring Indigenous knowledge on cultivation, uses and morphological differences of Cannabis landraces in South Africa’
https://www.sciencedirect.com/science/article/pii/S3117576726000297

In South Africa, an analysis of their master plan for cannabis entrepreneurship & the growing “cannabis divide” of marginalizing rural growers
‘Entrepreneurial Leadership and Cannabis Entrepreneurship in South Africa: Insights From the Cannabis Master Plan and SMME Performance Literature’
https://www.wr-publishing.org/index.php/ijarbm/article/view/680

In South Africa, an analysis of the global value chain of medical cannabis
‘Value capture in the emerging medical cannabis global value chain: insights from South Africa’
https://www.sciencedirect.com/science/article/pii/S0955395926002525

For medical cannabis in Brazil, an analysis of the regulations & their potential implications
‘Challenges for the new regulatory framework of medical Cannabis in Brazil’
https://www.scielo.br/j/csc/a/9nHffYHqsjd9MV8f5ZGZF9x/

After Thailand classified cannabis as a narcotic again in 2025, western travelers had a strong association between cannabis use & hazardous alcohol consumption, including high rates of intoxicated sex
‘Cannabis Use Among Western Travelers Following the 2025 Narcotic Relisting in Thailand: A Cross-Sectional Study’
https://rsucon.rsu.ac.th/files/proceedings/RSUSCI2026/IN26-073.pdf

For the cannabis of Ghana, on analyzing seized materials
‘Cannabinoid-Based Classification of Ghanaian Cannabis for Regulatory and Commercial Applications’
https://assets-eu.researchsquare.com/files/rs-9953080/v1/e2f6a744-1328-4dde-ae98-f5e4d0a8b632.pdf?c=1781538240

⚖️ Business, Laws & Education ⚖️

For medical cannabis in Germany after legalization, the price of cannabis flower decreased by 30% & higher THC content was found to predict demand
‘Supply and demand of medical cannabis in Germany after legalisation: exploring 12 months of data from an online dispensary’
https://www.sciencedirect.com/science/article/pii/S0955395926002690

On the term decriminalization, an excellent take on the looseness of the term
https://www.brookings.edu/articles/clarifying-debates-about-drug-decriminalization/

An excellent breakdown of the pharmaceutical model gobbling up the full-plant-extract domain to the detriment of the cannabis dispensary model
https://delpotterphd.substack.com/p/how-the-cannabis-movement-just-lost

Releaf becomes the first medical Company to be B Corp certified
https://businessofcannabis.com/releaf-becomes-first-ever-b-corp-certified-medical-cannabis-company/

For a Canadian media analysis of First Nations representation, there was a gap in understanding the cannabis industry & entrepreneurship through the lens of Indigenous self-determination
‘Indigenous Entrepreneurship in the Canadian Cannabis Industry: A Media Analysis Explored Through Self-Determination Theory’
https://onlinelibrary.wiley.com/doi/full/10.1002/cjas.70076

🚗 Driving 🚗

For cannabis & traffic fatalities, a response to another article correcting cannabis-attributed traffic fatalities in the US from 5000 per year to 3550 (#driving)
‘How many traffic fatalities can be attributed to cannabis each year in the US?’
https://www.sciencedirect.com/science/article/pii/S0955395926002586

In the motorcyclists of 2 Brazilian cities, ~10% tested positive for THC, with the positive testing age peaking at 32 years old, with a history of prior crashes associated with a higher odds of THC positivity
‘Cannabis use among motorcyclists in Brazil: prevalence and associated factors from a cross-sectional study in two cities’
https://www.tandfonline.com/doi/abs/10.1080/15389588.2026.2681922

🚓 The War on Drugs 🚓

Not only are Trump’s boat strikes inhumane & illegal, they’re also ineffective & even counterproductive
https://www.theatlantic.com/national-security/2026/07/trump-narcoterrorists-boat-strikes/687763/

In Mexico, a new report found that Trump’s campaign against Mexican drug cartels did not dent the US fentanyl supply
https://www.ntd.com/mexicos-drug-cartel-crackdown-fails-to-dent-fentanyl-flow-to-us-report-says_1158269.html

On the fascinating story of the elite Chinese university graduate who connected the Mexican cartels to fentanyl precursors & who seems to have had quite a wild ride of it
https://www.bbc.com/news/articles/c39ymggglxeo

On the unstoppable intricacies of the cartels laundering US drug sales through local Latino businesses
https://english.elpais.com/usa/2026-06-30/using-pinata-and-clothing-stores-in-the-us-cartels-keep-sending-millions-in-drug-proceeds-to-mexico.html

On the use of drones by Latin American cartels, an analysis of their strategic uses for instilling fear, forcing compliance & shaping behavior among civilians, other cartels & local & state governments
‘Cartel aerial operations: exploring Latin American cartels´ use of unmanned aerial vehicles (UAVs) as a tool for strategic coercion’
https://www.tandfonline.com/doi/pdf/10.1080/17467586.2026.2684959

On the use of cyberspace by narco-terrorist groups in western Southeast Asia
‘The Strategic Used of Cyberspace by Narco-Terrorist Groups Belonging to Kuki-Chin-Mizo’s in The Western Southeast Asia’
https://jisip.jurnaliisipjakarta.id/index.php/jisip/article/view/450

For Colombian cocaine trafficking, a high-level analysis of what works and doesn’t work to lessen the production & flow
https://quincyinst.org/research/demilitarizing-counternarcotics-25-years-of-evidence-from-colombia/

In Colombia, more on how the War on Drugs makes things worse
https://www.dropsitenews.com/p/dea-colombia-segunda-marquetalia-venezuela-maduro-santrich-petro

In Saudi Arabia, 3 Somali nationals executed for hashish smuggling
https://cannabislaw.report/saudi-arabia-executes-three-somali-nationals-convicted-of-hashish-smuggling/

In Tanzania, a 30-year sentence for trafficking cannabis
https://cannabislaw.report/tanzania-30-year-prison-sentence-handed-down-for-cannabis-trafficking/

In Indonesia, 12 people arrested & 3 tons of cannabis seized that was intended for vapes
https://cannabislaw.report/indonesia-seizes-3-37-tonnes-of-cannabis-buds-intended-for-vapes/

In France, 2.5 tons of cannabis bound for Libya seized
https://cannabislaw.report/strange-routing-french-customs-seize-2-5-tonnes-of-cannabis-bound-for-libya/

In New Jersey, 31 people charged for a synthetic cannabinoid trafficking ring into a prison using paper laced with MDMB-4en-PINACA
https://cannabislaw.report/new-jersey-drug-trafficking-ring-in-camden-county-correctional-facility-legal-correspondence-laced-with-mdmb-4en-pinaca-a-synthetic-cannabinoid/

In Toronto, police corruption & a conspiracy to operate illegal cannabis dispensaries & massage parlors
https://globalnews.ca/news/11954307/project-south-marijuana-dispensary/

In the UK, 103 people arrested & ~4 pounds of synthetic cannabinoids seized
https://www.bbc.com/news/articles/cn75188m3ypo

In San Diego, California, a fake “Buy 4 Less” store contained a hidden entrance to a sophisticated cross-border tunnel to Tijuana for cocaine trafficking
https://www.aol.com/articles/fake-california-store-had-hidden-183028000.html

In Spain, a couple demands compensation for the 30 kg of hemp seized & destroyed by the authorities
https://cannabislaw.report/spanish-farmers-demand-compensation-after-seizure-of-hemp-harvest/

WoD Research

For online drug markets, an analysis of why they have flourished in Europe but remained marginal in Latin America
‘Trust, infrastructure and sociopolitics in online drug markets: an exploratory socio-technical analysis of cryptomarket uptake in Europe and Latin America’
https://link.springer.com/article/10.1007/s12117-026-09604-9

On the crack cocaine epidemic of the US in the ‘80s, an analysis of how it escalated punitive drug enforcement & embedded immigration within the War on Drugs
‘‘Crack’: Immigration, national security, and the war on drugs in the USA’
https://academic.oup.com/ajlh/advance-article-abstract/doi/10.1093/ajlh/njag004/8722562

In Syria, an analysis of the trade in captagon (a stimulant mixture)
‘The Captagon Trade In Syria In The Eyes Of UNTOC: A Case Study’
https://sicedu.org/index.php/sicedu/article/view/631

For the Netflix show ‘Narcos’, an analysis of how it condemns interventionist policies
‘Catering to Underserved Global Perspectives: Narcos and America’s Drug War on Netflix’
https://www.researchgate.net/publication/407471775_Catering_to_Underserved_Global_Perspectives_Narcos_and_America’s_Drug_War_on_Netflix

For Mendoza’s anti-Philippine War on Drugs film ‘Ma’ Rosa’, a media analysis of its criticism of institutional abuse
‘Capturing and Challenging the War on Drugs in the Philippines: An Ideological Criticism of Brillante Mendoza’s Ma’Rosa’
https://saliksik.upd.edu.ph/storage/submission/pdf/manuscripts/eBSzLcV3AGuE4vw7Q47mZV77KIrpi9FmjXCUUCwx.pdf

On the first discovered clandestine synthetic cannabinoid lab in Brazil & how it produced MDMB-4en-PINACA
‘Insights from the first synthetic cannabinoid clandestine lab dismantled in Brazil’
https://www.sciencedirect.com/science/article/pii/S0379073826002458

For synthetic opioid smuggling at the US border, a thesis project on the tactics used by US border officials
‘FENTANYL AT THE BORDER: A CRITICAL ANALYSIS OF U.S. CUSTOMS AND BORDER PROTECTION STRATEGIES AGAINST SYNTHETIC OPIOID SMUGGLING’
https://digitalcommons.liberty.edu/cgi/viewcontent.cgi?article=9639&context=doctoral

For anti-drug operations in the capital of the Philippines, interviews on the difficulties faced by the anti-drug operatives
‘CHALLENGES FACED BY PHILIPPINE DRUG ENFORCEMENT AGENCY OPERATIVES IN THE NATIONAL CAPITAL REGION: AN EXAMINATION OF OPERATIONAL ISSUES’
https://cdn.eprapublishing.org/article/202602-02-026290.pdf

In United Arab Emirates, a review of their response to transnational drug crime
‘Transnational Drug Crime: A Case Study of the United Arab Emirates’ Response to Emerging Threats’
https://injoere.com/index.php/injoere/article/view/715

After the scheduling of synthetic cannabinoids in the United Arab Emirates, there was a steady increase of police seizures, with most being found on herbal materials, paper or liquid form
‘The impacts of proactive scheduling of synthetic cannabinoid receptor agonists on police drug detections in Dubai, United Arab Emirates (2011–2022)’
https://www.sciencedirect.com/science/article/pii/S0955395926002628
“The most commonly detected SCRA evolved over the study period, with JWH-019 predominating in 2011, followed by AM-2201 (2012–2013), AKB48 (2014), AB-CHMINACA (2015), 5-fluoro AKB48 analogues (2016–2018), 5F-MDMB-PICA (2019), 5-fluoro MDMB-PINACA (2020), and MDMB-4en-PINACA by the end of the study period (2021–2022).”

🛡️ Harm Reduction News 🛡️

Excellent journalism on the aftermath of closing the Moss Park safe consumption site in Toronto
https://thelocal.to/moss-park-safe-consumption-site-closure/

In Ontario & Niagara after the dismantling of harm reduction infrastructure, a surge of 911 calls for overdose emergencies
https://streamlinefeed.co.ke/news/supervised-site-closures-trigger-surge-in-ontario-overdose-emergencies
https://thepointer.com/article/2026-07-09/the-closure-of-niagara-s-safe-consumption-and-treatment-site-causes-immediate-impacts-increased-overdoses-and-ems-calls

Harm Reduction Research

In Appalachia, an analysis of how law enforcement captured the national opioid settlement money, with variations from West Virginia’s 40% to North Carolina’s 2.6% (#opioidsettlement)
‘Law enforcement capture of opioid settlement funding across Appalachia’
https://www.sciencedirect.com/science/article/abs/pii/S0955395926002550

In people who inject opioids, higher levels of pain severity are associated with reduced safe injection practices
‘Pain is associated with reduced adherence to safer injection practices among people who inject opioids’
https://link.springer.com/article/10.1186/s12954-026-01490-2

For survivors of sex trafficking, on harm reduction approaches to their drug use
‘“People are going to do drugs:” harm reduction as a strategy for survivors of sex trafficking who use substances’
https://link.springer.com/article/10.1186/s12954-026-01471-5

An excellent rundown on the lessons learned from Canada’s fraught safer supply opioid program during the height of the overdose crisis
‘The Rise and Fall of Safer Supply Programs in Canada’
https://jamanetwork.com/journals/jama-health-forum/fullarticle/2848523

On Canadian perspectives on supervised consumption sites, the general public perceived positive impacts on overdose risk, access to healthcare, harm reduction & social services as well as reducing public drug use & discarded needles
‘Public perspectives on supervised consumption sites across Canada: A cross-sectional study’
https://www.sciencedirect.com/science/article/pii/S095539592600263X

For naloxone distribution in the US, there was a marked increase between 2018 & 2023, especially distribution to non-healthcare settings & for nasal spray devices
‘Naloxone Distribution in the United States, 2018–2023’
https://ajph.aphapublications.org/doi/abs/10.2105/AJPH.2026.308541

For improving access to take-home naloxone, on allowing for use in an adult home treatment team
‘Improving Access to Take-Home Naloxone for Service Users at Risk of Opioid Overdose in an Adult Home Treatment Team: A Quality Improvement Project’
https://www.cambridge.org/core/journals/bjpsych-open/article/improving-access-to-takehome-naloxone-for-service-users-at-risk-of-opioid-overdose-in-an-adult-home-treatment-team-a-quality-improvement-project/3A5179B611A4636D66A0D945795BE370

Interviews in Sweden with Supersavers (people who have administered naloxone 3+ times)
‘“You’ve involved us knowing that we don’t think about the law like you”: a qualitative study on Supersavers’ perspective of overdose engagement in Skåne county, South Sweden’
https://link.springer.com/article/10.1186/s12954-026-01487-x

In non-urban communities, interviews on the benefits of harm reduction vending machines
‘Harm reduction vending machines: An opportunity to bridge the resource access gap in non-urban communities’
https://www.sciencedirect.com/science/article/abs/pii/S1353829226000730

In Belgium, the first fatal mono-intoxication with protonitazepyne (a Nitazene analogue)
‘Fatal mono-intoxication with novel synthetic opioid protonitazepyne (N-pyrrolidino protonitazene)’
https://www.sciencedirect.com/science/article/pii/S2665910726000459

For public health & drug-induced homicide laws, a review of 8 studies found negative consequences such as deterring people from calling 911 to report an overdose, with the laws overwhelmingly used in response to the death of a white person
‘The public health impacts of drug-induced homicide laws: a community-engaged scoping review’
https://link.springer.com/content/pdf/10.1186/s40352-026-00419-y_reference.pdf

For naloxone, a review of its pharmacology
‘Molecular pharmacology and structural insights of naloxone: a comprehensive review’
https://link.springer.com/article/10.1007/s44345-026-00060-0

For take-home naloxone, a review of 24 studies found that its use is supported by both patients & emergency department providers alike
‘A scoping review of emergency department take-home naloxone on patient and health outcomes’
https://link.springer.com/article/10.1007/s43678-026-01208-0

🍄 Psychoactives, Psychedelics & Plant Medicines 🍄

Eli Lilly, the world’s largest pharmaceutical company, plans to acquire AtaiBeckley, a psychedelic company with a 5-MeO-DMT drug entering late-stage clinical trials
https://psychedelicalpha.com/news/breaking-worlds-largest-pharmaceutical-company-eli-lilly-acquires-5-meo-dmt-developer-ataibeckley-for-up-to-3-8-billion/

A fascinating article on a new source for the ibogaine molecule that the researcher is keeping secret to protect the plant & his plans to pioneer a novel & sustainable way of producing this remarkable drug (#ibogaine)
https://news.mongabay.com/2026/06/secret-amazon-species-may-be-new-source-of-ibogaine-for-addiction-treatment/

Psychedelics & MDMA

For the safety of ibogaine, an analysis of fatalities found that they were all among people with opioid use disorder
‘Indication-stratified mortality risk of ibogaine treatment under contemporary safety protocols: a multisite analysis of 19,071 patients and updated systematic review of fatalities’
https://assets-eu.researchsquare.com/files/rs-9966269/v1/e1a44af1-469c-49a1-b1c3-49ecaf6e90dd.pdf

In people with ADHD, low-dose LSD altered temporal processing but no other neuropsychological domains, with no “convincing evidence for broad cumulative benefits”
‘Effects of repeated low-dose LSD on neuropsychological functioning in adults with ADHD: a randomized placebo-controlled study’
https://link.springer.com/article/10.1007/s00213-026-07107-7

For autism & psychedelics, a review on the mechanisms, the evidence & the ethical concerns
‘Psychedelics and autism spectrum disorder: Mechanistic insights, translational evidence and ethical challenges’
https://www.sciencedirect.com/science/article/pii/S0022395626003432

For music in psychedelic therapy, a review of 19 papers found considerable gaps, including no data at all on MDMA & music
‘Psychedelic Therapy and the Role of Music: A Scoping Review of Quantitative Evidence on Subjective and Objective Outcomes’
https://pubmed.ncbi.nlm.nih.gov/42348297/

Ketamine

For PTSD & ketamine, a meta-analysis of 12 studies found a higher baseline of PTSD severity was the most robust predictor of symptom reduction
‘Ketamine-assisted psychotherapy for posttraumatic stress disorder: a systematic review and individual participant data meta-analysis of predictors of treatment effects’
https://karger.com/pps/article-pdf/doi/10.1159/000553144/4551237/000553144.pdf

For at-home telehealth-supported ketamine therapy, it was safe & effective for depression, anxiety & PTSD
‘At-Home Telehealth-Supported Subcutaneous Ketamine Therapy in Adults With Moderate to Severe Depression, Anxiety, or PTSD: A Real-World Observational Study of Safety, Feasibility, and Clinical Outcomes in a Large, Heterogeneous Cohort in the United States’
https://pubmed.ncbi.nlm.nih.gov/42319752/

In adults & children with cancer pain, IV ketamine reduced peak cancer pain
‘Intravenous Ketamine for Refractory Cancer Pain in 433 Adults and Children: A Real-World Retrospective Study from a Comprehensive Cancer Centre in Jordan’
https://www.preprints.org/frontend/manuscript/363ef325ba4b445249a8998dfa73baef/download_pub

In an older man with psychotic depression, a case report of ketamine injections as a short-term bridging intervention while ECT was temporarily too high-risk
‘Trial of subcutaneous ketamine for psychotic depression in an older adult with comorbid physical illness: a case report’
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/78A1E01544F6A9A4475211637867F99A/S2056472426117803a.pdf/div-class-title-trial-of-subcutaneous-ketamine-for-psychotic-depression-in-an-older-adult-with-comorbid-physical-illness-a-case-report-div.pdf

A case report of a ketamine user with severe rhabdomyolysis (muscle breakdown releasing proteins into the bloodstream) leading to an acute kidney injury requiring dialysis
‘Dialysis-Requiring Acute Kidney Injury Secondary to Severe Rhabdomyolysis in a Recreational Ketamine User’
https://assets.cureus.com/uploads/case_report/pdf/487639/20260626-187601-qqs10j.pdf

For severe ketamine use disorder, a case report of ibogaine leading to sustained abstinence
‘Sustained abstinence in severe ketamine use disorder following ibogaine treatment’
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1846320/abstract

For ketamine misuse, a review of the potential treatments
‘Treatment and management approaches for ketamine misuse: A systematic review of medical interventions’
https://www.sciencedirect.com/science/article/pii/S2949875926001815

On ketamine for obsessive-compulsive disorder, a review of 5 studies found consistent & significant improvements
‘Ketamine for the Treatment of Obsessive-Compulsive Disorder (OCD): A Systematic Review on Efficacy and Tolerability’
https://pubmed.ncbi.nlm.nih.gov/42311186/

In people using ketamine for mood disorders, a review of 30 studies found minimal evidence of it causing cravings, dose escalation or illicit use
‘Evaluating the abuse liability of ketamine in the treatment of mood disorders: A systematic review’
https://journals.sagepub.com/doi/pdf/10.1177/02698811261453814

For ketamine combined with psychotherapy, a review of studies found that while certain modalities (CBT, BA, ASAT) may moderately prolong ketamine’s antidepressant effects, the results are heterogeneous
‘Psychotherapy and Ketamine: How Does This Combination Affect the Duration of the Antidepressant Effect?’
https://dev-ojs.e-medjournal.com/index.php/psp/article/view/720

On augmenting hypnotherapy with ketamine
‘Ketamine-Augmented Hypnotherapy’
https://www.preprints.org/manuscript/202606.2224

In a rat model of ketamine-induced neurotoxicity, how the severe cognitive deficits & anxiety-like behaviors were mitigated by the potent antioxidant mangiferin
‘Alterations in glutamatergic and GABAergic signaling in ketamine-induced neurotoxicity: mangiferin mitigates neurochemical, oxidative, and astrocytic dysregulation in the rat temporal–frontal cortex’
https://link.springer.com/article/10.1186/s12993-026-00348-8

Kratom

For semi-synthetic kratom products, these researchers declared a public health emergency because of the high doses now available
‘Semi-synthetic products based on 7-hydroxymitragynine: a public health emergency’
https://esmed.org/MRA/mra/article/view/7596

For kratom, a case report of its potential link to a stroke
‘Chronic Kratom Use as a Potential Risk Factor for Embolic Stroke of Undetermined Source: A Case Report’
https://assets.cureus.com/uploads/case_report/pdf/488296/20260623-135977-apk3dg.pdf

For kratom, a case report of a large quantity of 7-OH leading to profound central nervous system depression & intensive ICU care
‘The Bitter Aftertaste of Kratom: A Toxicologic and Neurologic Challenge’
https://assets.cureus.com/uploads/case_report/pdf/482017/20260630-183835-jiw2n7.pdf

For kratom, a review of its neurocircuitry effects & impacts on cognition & behavior
‘Decoding the Neurocircuitry of Kratom: Impacts on Behaviour and Cognition’
https://www.sciencedirect.com/science/article/abs/pii/S2468867326000775

On kratom extract for healing diabetic ulcers, a review of 8 studies found some limited preclinical evidence supporting biological plausibility
‘Efficacy of Mitragyna speciosa (Kratom) Extract for Diabetic Ulcer Healing: A Literature Review’
https://journal-jps.com/new/index.php/jps/article/view/1648

Khat

For khat in Somaliland, a review of its economics, problems & potential for social harm reduction
‘The Khat Conundrum: Balancing Economic Reality, Social Welfare, and Sovereignty in Public Policy for Somaliland’
https://www.researchgate.net/publication/407461665_The_Khat_Conundrum_Balancing_Economic_Reality_Social_Welfare_and_Sovereignty_in_Public_Policy_for_Somaliland

Kava

For kava, brain scans found different effects in two experienced users
‘Neurophysiological Effects of Traditionally-Prepared Kava Measured by EEG: A Pilot Case Study’
https://www.neuroregulation.org/article/view/23587

🍃 The Plant & its Products 🍃

🌱 Growing 🌱

In a long-term monoculture of cannabis (90+ years), on the differences in the soil microbiome between fertilized & unfertilized plots
‘Soil microbiota of industrial hemp (Cannabis sativa L.) grown in a long-term monoculture’
https://link.springer.com/article/10.1186/s44314-026-00045-w
What a quiet flex. 90 years of growing cannabis in one spot.

For Moroccan cannabis, on analyzing the effects of gibberellic acid, hydrogen peroxide, temperature, photoperiod exposure, total darkness, mechanical scarification & salt stress
‘Influence of extrinsic factors and salt stress on the in vitro germination and development of Moroccan Cannabis sativa L. varieties as potential medicinal plants’
https://agris.fao.org/search/en/providers/122356/records/6a0b2a88e7cc3e7ab044e1fd

In young cannabis plants under stress from zinc & the heavy metal cadmium, an imaging metabolic & hormonal study of the changes
‘Unravelling the protective role of silicon in Cannabis sativa hypocotyls under cadmium and zinc stress with imaging and -omics’
https://www.sciencedirect.com/science/article/pii/S2667064X26002460

For hemp grown in forever chemicals, humic acids did not greatly affect accumulation
‘PFAS-induced morpho-physiological, photosynthetic and tissue accumulation responses of pot-grown hemp, sunflower and maize under soil amendment with humic acids’
https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2026.1791472/full

For ultraviolet light in cannabis cultivation, this thesis found UVB to strongly stimulate production of pigments, sesquiterpenoids & flavonoids
‘A Portrait Under Ultraviolet: Physiological and Biochemical Responses in Medicinal Cannabis’
https://research.wur.nl/en/publications/a-portrait-under-ultraviolet-physiological-and-biochemical-respon/

For hop latent viroid, on the different distributions through leaves & roots depending on cannabis genotype
‘Cannabis genotypes display differences in the tissue distribution and levels of Hop latent viroid in leaves and roots following inoculation’
https://www.tandfonline.com/doi/pdf/10.1080/07060661.2026.2680120

For the parasitic roundworm Nacobbus celatus, the first report of cannabis susceptibility
‘First report of susceptibility of Cannabis sativa to Nacobbus celatus’
https://brill.com/view/journals/nemy/aop/article-10.1163-15685411-bja10499/article-10.1163-15685411-bja10499.xml

For Phytoplasmas (bacteria that feed on agriculturally important plants), a study from India finds cannabis to be a natural reservoir, an epidemiological “green bridge”
‘Global diversity and reservoir role of Cannabis sativa L. in phytoplasma epidemiology with insights from brinjal little leaf disease’
https://link.springer.com/article/10.1007/s42360-026-00997-9

With calcium for cannabis cultures, on the effects on secondary metabolite production
‘Effect of calcium phosphate on growth, pigment and secondary compound accumulation in Cannabis sativa L. callus’
https://li04.tci-thaijo.org/index.php/IJAT/article/view/11737

For hemp field retting, on the effects of moisture conditions
‘Exploring the influence of abiotic factors on the hemp field retting process: Moisture impact assessment’
https://www.sciencedirect.com/science/article/pii/S0926669026011519

In cannabis roots, an analysis found high levels of fatty acids, glycerol esters & phytosterols
‘Identification of a Non-Cannabinoid Lipid–Sterol Chemotype in Cannabis sativa Roots using SCFE–GC–MS Analysis’
https://jahm.co.in/index.php/jahm/article/view/2774

For cannabis chemotypes (different ratios of cannabinoids produced) & the link between the genetic expression & the actual cannabinoid levels, an analysis found that certain genetic variants of synthesis enzymes are stronger drivers of production
‘An integrated view of haplotype, gene expression and allelic variation explains the chemotype and cannabinoid yield of Cannabis sativa’
https://www.sciencedirect.com/science/article/pii/S0926669026011374

During cannabis seed germination under stress conditions, a genetic analysis of the GATA transcription factors (zinc finger proteins that regulate many developmental & stress responses)
‘Whole-genome analysis reveals the tandem duplication of Cannabis sativa L. GATA and their stress-responsive expression during seed germination’
https://link.springer.com/article/10.1186/s12870-026-09308-w

In cannabis under drought conditions, an analysis of changes to the long non-coding RNAs (key regulators of plant stress responses)
‘Long non-coding RNA landscape and ceRNA networks underlying the drought response of Cannabis sativa L.’
https://link.springer.com/article/10.1186/s12870-026-09380-2

In cannabis under phosphorus deficiency, a genetic analysis of the response in different tissues
‘Co-expression analysis identifies organ-specific gene regulatory networks responsive to phosphate limitation in hemp (Cannabis sativa L.)’
https://link.springer.com/article/10.1186/s12870-026-09379-9

In Ukraine, on the prospects for growing industrial hemp
‘Prospects for growing industrial hemp in Ukraine’
https://dspace.mnau.edu.ua/jspui/handle/123456789/26301

In Kentucky, on the ecosystem benefits of expanding hemp cultivation for crop diversity, water quality & bird diversity
‘Hemp Cultivation and Crop Diversification: Implications for Ecosystem Services in Kentucky’
https://onlinelibrary.wiley.com/doi/pdf/10.1002/aepp.70099

⚙️ Extracting, Analyzing & Formulating ⚙️

In hydrocarbon cannabis extraction, control of the temperature can minimize alkanes carried over from the wax
‘Temperature Control Minimizes Wax-Derived Alkane Carryover in Hydrocarbon Cannabis Extraction’
https://pubs.acs.org/doi/full/10.1021/acsomega.5c13451

For the supercritical CO2 extraction of caffeine & CBD, on collecting molar volume data & optimizing extraction
‘Towards optimizing extraction and purification technologies: Partial molar volumes and solubilities of caffeine and cannabidiol in high-pressure CO2’
https://www.sciencedirect.com/science/article/pii/S2212982026001873

On the different extraction methods for hemp oil, an analysis of their impact on yield & quality
‘METHODS OF HEMP OIL PRODUCTION AND THEIR IMPACT ON PRODUCT YIELD AND QUALITY’
https://iprjournal.kyiv.ua/index.php/pr/article/view/825

On the methods for analyzing cannabis & pharmaceutical products, a review of approaches
‘ANALYTICAL TECHNIQUES FOR CANNABINOIDS IN CANNABIS AND ITS PHARMACEUTICAL PRODUCTS: A REVIEW’
https://wjpr.s3.ap-south-1.amazonaws.com/article_issue/df908d6d426f56647058a29b0e712ee7.pdf

For the plant bioactives CBD & hesperetin (a flavanone found in citrus), on improving their bioavailability via hotmelt extrusion into an amorphous dispersion
‘Development and Characterization of Amorphous PVP K30–Phosphatidylcholine Dispersions for the Fixed-Dose Co-Delivery of Hesperetin and Cannabidiol Prepared by Hot-Melt Extrusion’
https://link.springer.com/article/10.1208/s12249-026-03484-6

🍞 Food & Nutrition 🍞

In trout fish meatballs enriched with hemp flour, an analysis of the nutritional & lipid quality improvements
‘Evaluation of nutritional, chemical, and microbiological changes in trout fish meatballs enriched with hemp flour’
https://link.springer.com/article/10.1007/s11694-026-04652-9

For Moroccan cannabis seeds, an analysis of their macroelements & essential trace elements
‘Elemental profiling of Cannabis sativa L. seeds from Northern Morocco using neutron activation analysis technique at CNESTEN-Morocco’
https://link.springer.com/article/10.1007/s10967-026-10997-8

For assessing hemp seed quality, on updating the methodology for the dynamics of their flow
‘Improvement of the methodology for assessing the properties of industrial hemp seeds’
https://www.researchgate.net/publication/408358080_Improvement_of_the_methodology_for_assessing_the_properties_of_industrial_hemp_seeds

On stabilizing hemp seed oil bodies with chitosan
‘Elucidation of pH-regulated chitosan-hemp seed oil bodies composites: structural stability, interfacial kinetics, and in vitro digestion behavior’
https://www.sciencedirect.com/science/article/abs/pii/S0268005X26006314

🏗️ Industrial Uses & Fiber 🏗️

For root-knot nematodes in tomatoes, fumigating with cannabis leaf residues inhibited hatching & increased tomato root mass
‘Biofumigation with Cannabis sativa leaves on the management of root-knot nematode Meloidogyne javanica in tomato’
https://www.sciencedirect.com/science/article/pii/S0261219426002115

For removing the heavy metal cadmium from water, on enhancing the efficacy of biochar & geopolymer composites with hemp straw
‘Hierarchical Porous Biochar/Geopolymer Composite Derived from Hemp Straw for Enhanced Cadmium Remediation in Aqueous and Soil Environments’
https://link.springer.com/article/10.1007/s11270-026-09718-4

For hemp footwear, on optimizing for shape stability
‘Optimization of shape stability of hemp footwear textiles through constructive and technological solutions’
https://www.researchgate.net/publication/407171052_OPTIMIZATION_OF_SHAPE_STABILITY_OF_HEMP_FOOTWEAR_TEXTILES_THROUGH_CONSTRUCTIVE_AND_TECHNOLOGICAL_SOLUTIONS

For turning hemp into a feedstock for cellulose fibers, an analysis of the best conditions for acid sulfite usage for dissolution found them lacking
‘Acid Sulfite Pulping of Hemp: Effects of Processing Conditions on Lyocell Pulp Quality’
https://onlinelibrary.wiley.com/doi/pdf/10.1002/pola.70228

For hemp-reinforced packaging, on the best ratios for enhancing stiffness
‘Influence of PBAT Pellet and Powder Forms on the Properties of Hemp Fiber-Reinforced Composites and Assessment of Their Thermoforming Feasibility’
https://onlinelibrary.wiley.com/doi/abs/10.1002/app.70999

For polymer composites, on the effects of adding hemp & polyester for dissipating mechanical energy
‘Effect of cyclic loading mode on the damping behavior of polymer composites reinforced with natural fibers (Hemp and Cotton) and glass fibers’
https://www.sciencedirect.com/science/article/abs/pii/S1359835X26004653

In hemp fiber-epoxy composites, on validating an AI for analyzing deformation behavior
‘ANN-driven Modelling of Deformation and Notch Sensitivity in Hemp Fiber–Epoxy Composites Under Tensile and Edge-notched Tensile Loading Conditions’
https://link.springer.com/article/10.1007/s40033-026-01042-9

In hemp dyeing, on using green chemistry to utilize sources like black carrots & their anthocyanins & anthocyanidins
‘Green Chemistry in Hemp Dyeing’
https://www.proquest.com/openview/4795d9411481c4d80793df16eaa85545/1?pq-origsite=gscholar&cbl=2032400

For hemp concrete, on improving thermal energy storage with phase-change material
‘Thermo-hygro-mechanical performance of hemp concrete incorporating bio-based phase change material: Experimental and numerical characterization’
https://www.sciencedirect.com/science/article/abs/pii/S2352710226014786

On expansive clay soils, waste hemp stocks significantly reduced liquid limit, plasticity index, swelling percentage & swelling pressure
‘Waste hemp stabilisation of expansive soils: behaviour and sustainability assessment’
https://www.emerald.com/jenge/article-abstract/doi/10.1680/jenge.25.00179/1383133/Waste-hemp-stabilisation-of-expansive-soils

For calcareous sands (often used for golf course construction), hemp fiber was the weakest for improving strength of the fibers tested
‘Comparative Evaluation of Ramie, Hemp, and Hollow Fibers on the Mechanical Properties of MICP-Treated Calcareous Sand’
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1869298/abstract

In hemp concrete, a laboratory round-robin test on thermal conductivity found moisture to be the most critical source of uncertainty & measurements
‘RILEM TC 275-HDB: interlaboratory assessment of thermal conductivity measurements in hemp concrete’
https://www.researchsquare.com/article/rs-9981846/v1

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

🏥 Public Health & Bioassays 🏥

For the idea of standard THC units, a focus group of cannabis consumers found that they were broadly enthusiastic about the idea, thinking that it would be beneficial for both novices getting used to ingestion as well as for experienced consumers focused on tolerance management
‘Cannabis consumer responses to the concept of standard THC units’
https://pubmed.ncbi.nlm.nih.gov/42331728/

In people exposed to coverage of natural disasters, they were more likely to use cannabis & alcohol
‘Exposure to disaster information on social media, depressive symptoms, and alcohol and cannabis use in the aftermath of two natural disasters’
https://www.sciencedirect.com/science/article/pii/S2352853226000593

In Asian Americans & US Pacific Islanders, the cannabis users were more likely to be born in the US & to report more anxiety, depression, tobacco use, tobacco dependence & negative consequences from tobacco smoking
‘Dual nicotine and cannabis use among Asian American and Pacific Island adults: the role of anxiety and negative reinforcement expectancies on nicotine outcomes’
https://www.tandfonline.com/doi/full/10.1080/16066359.2026.2693279

Among Thai adults at a sexual health clinic, cannabis use was associated with sex under the influence of drugs & alcohol
‘Cannabis use, sexual behaviors, and HIV prevention behaviors among young adults attending key-population-led sexual health clinics in Bangkok, Thailand: A mixed-method study’
https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0352395

In Nepali men who have sex with men & use cannabis, a survey of their demographics
‘Characteristics of cannabis use among men who have sex with men in Nepal: A respondent-driven cross-sectional survey’
https://www.ovid.com/jnls/md-journal/fulltext/10.1097/md.0000000000049475~characteristics-of-cannabis-use-among-men-who-have-sex-with

For urine drug testing, on false negatives from benzalkonium chloride (often found in eyedrops & antiseptics)
‘Behind the Mask: Detection and Characterization of Benzalkonium Chloride Adulteration in Immunoassay-Based Urine Drug Testing for Tetrahydrocannabinol (THC)’
https://pubs.acs.org/doi/full/10.1021/acsomega.6c03171

For detecting THC metabolites in urine, on creating a less costly detection strategy
‘Isotope-Coded Derivatization Enables Accurate LC–MS/MS Quantification of Urinary THC–COOH without Isotope-Labeled Cannabinoid Standards’
https://pubs.acs.org/doi/abs/10.1021/jasms.6c00110

🧒 Adolescents & Young Adults 🧒

For young people in Germany after partial legalization, adolescents & young women had no change in the prevalence of cannabis use between 2023 & 2025, but there was an increase in consumption among young men, though this is a continuation of a trend that started in 2008
‘One year after partial legalisation in Germany: Trends in cannabis use among
Young people between 2008 and 2025’
https://edoc.rki.de/bitstream/handle/176904/13777/johm_11_11.pdf?sequence=1&isAllowed=y

On cannabis-related school discipline, interviews of youth found extensive student surveillance, a wide array of disciplinary responses, perceptions of disproportionate punishments & advocacy for harm reduction
‘“Just take it away from them and talk to them about it”: exploring youth perspectives on and experiences with cannabis-related school discipline’
https://www.sciencedirect.com/science/article/abs/pii/S0955395926002653

For the harm perceptions of smoking versus vaping in young adults, few perceived cannabis smoking to be more harmful than cannabis vaping
‘Harm perceptions of smoking versus vaping cannabis and correlates: national surveys of youth and young adults in England, Canada, and the United States’
https://www.sciencedirect.com/science/article/pii/S0306460326001954

In young adults in Québec after legalization, interviews found their motivations for daily cannabis use included management of mental & physical health, relaxation, spirituality & enhancement of everyday experiences, with strategies to limit their usage by modulating their dosage & product types, limit use to the evenings & to abstain before work or study
‘Understanding Daily Cannabis Use among Young Adults in Post-Legalization Québec: Motivations, Consumption Practices, and Control Strategies’
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2693050

In US adolescents, a parental history of drug use predicted higher negative urgency, greater cannabis positive expectancies & lower negative expectancies
‘Adolescent Cannabis Expectancies Are Associated With Parental Drug Use History Via Negative Urgency’
https://www.jsad.com/doi/abs/10.15288/jsad.26-00026

In French young adults who co-use tobacco & cannabis & who want to quit, lower socioeconomic status was associated with a greater frequency of use & a greater readiness to quit, with financial strain being a common determinant of motivation
‘Crossed Pathways: Tobacco–Cannabis Co‐Use and Motivation to Quit in Young Adults in France’
https://onlinelibrary.wiley.com/doi/pdf/10.1111/dar.70195

For decreasing the use of nicotine & cannabis in adolescence, a review of Brief Negotiated Interviews (a structured collaborative conversation to help patients reduce risky behaviors, an offshoot of Motivational Interviewing) found a 15-minute intervention significantly decreased substance use in the short-term but had minimal long-term effects
‘The Value of Brief Intervention to Prevent and Decrease Nicotine, Tobacco, and Cannabis Use among Adolescents’
https://journals.sagepub.com/doi/abs/10.1177/23727322261462461

At a Brazilian university, on the demographics of who was using cannabis
‘Prevalence of marijuana use and associated factors among students at a university in the east of Minas Gerais, Brazil’
https://www.scielo.br/j/csc/a/3DHNVg7dD84m47w3fSLNnGP/abstract/

🧠 The Brain & Neurological Disorders 🧠

In brain tissue from people with Alzheimer’s disease, there were few changes to their endocannabinoid machinery, but the status of the lipid transport protein APOE had gendered effects on the control of the endocannabinoid system
‘Sex- and APOE ε4-dependent expression patterns of the Cannabinoid Receptor-1, FAAH, and MAGL are weakened in late-onset Alzheimer disease frontocortical samples’
https://assets-eu.researchsquare.com/files/rs-9717404/v1_covered_d5219d48-5e2a-4caf-aead-465170451222.pdf?c=1781535331

In brain scans of healthy humans, this was the first ever study to track their levels of the enzyme MAGL (which breaks down the endocannabinoid 2-AG), but the radiotracer had low levels of brain uptake
‘Imaging Monoacylglycerol Lipase A First-in-Human Positron Emission Tomography Study with [18F]MAGL-2102’
https://www.researchsquare.com/article/rs-9586791/v1

In several models of spinal cord injury, the genetic transcription of components of the endocannabinoid system were found, suggesting an “ECS-associated immune remodeling signature in SCI [spinal cord injury]”
‘Cross-Species Transcriptomic Analysis Identifies an Endocannabinoid-Associated Immune Remodeling Signature and Candidate Pharmacologic Targets in Spinal Cord Injury’
https://www.mdpi.com/2227-9059/14/7/1446

In a rat model of neuroinflammation & cognitive dysfunction due to the pesticide chlorpyrifos, their disruptions to endocannabinoid signaling & a pre-diabetic state were significantly mediated by supplementation with arachidonic acid (the building block of the endocannabinoid anandamide)
‘Early prediabetes aggravates neuroinflammatory and cognitive dysfunctional responses to chlorpyrifos exposure: Possible amelioration by arachidonic acid’
https://www.sciencedirect.com/science/article/abs/pii/S0014299926005790

For Alzheimer’s disease, on creating drugs that target both the CB2 receptor & glutaminyl cyclase (a zinc-dependent enzyme related to the cascade of the amyloid plaques)
‘Design, synthesis and evaluation of dual modulators targeting glutaminyl cyclase and cannabinoid CB2 receptor’
https://www.sciencedirect.com/science/article/abs/pii/S022352342600560X

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

In Black men, depression scores were highest in those who are using cannabis & binge-drinking alcohol, followed by cannabis-only & binge-drinking only
‘Binge alcohol and cannabis co-use associated with depression in Black men’
https://psycnet.apa.org/record/2027-87277-001

In the lung tissue of people with alcohol use disorder, they had higher levels of anandamide
‘SPS2-05 Effects of Chronic Alcohol Drinking on Endocannabinoids / CB1R System in Lungs of Alcohol Use Disorder Patients’
https://academic.oup.com/ajrccm/article/212/Supplement_2/aamag286.194/8712438

Another one of these odd studies on people’s interest in buying edibles as a measurement of cannabis use disorder
‘Gimmie the Gummies: Initial validation of the Edibles Marijuana Purchase Task’
https://psycnet.apa.org/record/2027-91435-001

🧬 Reproduction & Hormones 🧬

In pregnant people using cannabis, interviews on how & why they were using protective behavioral strategies around their cannabis use
‘Use of Cannabis Protective Behavioral Strategies During Pregnancy’
https://publications.sciences.ucf.edu/cannabis/index.php/Cannabis/article/view/360

In interviews of perinatal nurses, an urgent need was found for developing nurse & patient education around perinatal cannabis use
‘Perinatal Cannabis Use: Nurse Perceptions and Educational Opportunities’
https://pubmed.ncbi.nlm.nih.gov/42318829/

For premenstrual symptoms, a survey found cannabis, alcohol & psychedelics to be the most utilized drugs
‘Cannabis, Psychedelics, and Other Substance Use to Manage Premenstrual Symptoms: A Survey Study’
https://journals.sagepub.com/doi/abs/10.1177/15409996261459360

For prenatal exposure, a review of the methods used in preclinical research
‘Diverse Methodologies Used for Preclinical Research into Prenatal Cannabis Exposure’
https://pubmed.ncbi.nlm.nih.gov/42330002/

In a rat model of uterine contractions, on the effects of different gold nanoparticles of CBD for lowering contractions
‘The effects of gold nanoparticles and nano-emulsions synthesized from cannabidiol oil on oxytocin-induced uterine contractions in rats’
https://www.frontiersin.org/journals/nanotechnology/articles/10.3389/fnano.2026.1880211/abstract

🦠 The Immune System & Microbial 🦠

For antibiotic effects, on sourcing silver nanoparticles from the leaves of cannabis & Indian bael
‘Microwave-assisted Synthesis of Silver Nanoparticles Using Cannabis sativa and Aegle marmelos Leaves for Potential Antibacterial Activity’
https://www.benthamdirect.com/content/journals/ccb/10.2174/0122127968442054260203165815

🦴 Pain, Musculoskeletal & Surgeries 🦴

For people on dialysis, those smoking cannabis had decreased average pain severity
‘Weighted analysis of the association between cannabis smoking and chronic pain intensity among hemodialysis patients’
https://www.nature.com/articles/s41598-026-57047-7_reference.pdf

In people having hip replacement surgery, cannabis use was not associated with any changes to outcomes, but increased usage correlated with worse pain symptoms
‘Functional Outcomes After Hip Arthroscopy Based on Self-Reported Cannabis Use: A Matched-Controlled Study’
https://journals.sagepub.com/doi/pdf/10.1177/23259671261450217

On CBD for painkilling, a new book chapter
‘Cannabidiol’
https://link.springer.com/chapter/10.1007/978-3-032-21675-5_17

In a mouse model of fentanyl use disorder, neutral antagonists of the CB1 receptor lessened the acquisition & expression of symptoms of opioid use disorder while not altering the opioid’s ability to lessen pain
‘Cannabinoid (CB) 1 receptor antagonists block fentanyl conditioned place preference but not fentanyl antinociception’
https://www.sciencedirect.com/science/article/abs/pii/S0376871626002243

In a rat model of neuropathic pain, inhibition of the enzyme MAGL (which breaks down the endocannabinoid 2-AG) reduced their mechanical & cold hypersensitivities & reversed their depression-like behaviors via the restoration of activity in their medial prefrontal cortex via the CB1 receptor
‘Dissociable peripheral and central mechanisms of monoacylglycerol lipase inhibition on pain- and depression-related behaviors in a rat model of neuropathic pain’
https://pubmed.ncbi.nlm.nih.gov/42350317/

In a rat model of knee osteoarthritis, a drug that activates the CB2 receptor caused sustained painkilling effects without inducing tolerance & when administered with morphine, enhanced its painkilling effect & lessened the symptoms of opioid withdrawal, especially in females
‘PM289, a synthetic CB2 in vitro receptor agonist, modulates morphine-induced antinociceptive effect and withdrawal syndrome in an animal model of osteoarthritic pain’
https://www.sciencedirect.com/science/article/abs/pii/S0028390826002649

For treatment-resistant chronic pain, on developing a nanoemulsion of cannabis extract
‘Development and clinical evaluation of a nanoemulsion for buccal delivery of cannabis extract in refractory chronic pain’
https://www.sciencedirect.com/science/article/pii/S0939641126001839

For the pain-sensing ion channels TRPA1 & TRPV1, CBD & CBG had more helpful effects than their carbamate derivatives
‘Carbamate-based cannabinoids uncover a conserved lipid-sensing pocket in nociceptive TRPA1 and TRPV1 channels’
https://www.sciencedirect.com/science/article/pii/S1043661826002343

For the antioxidant effects of cannabinoids, on a new diagnostic tool for analyzing their effects
‘Midpoint potential of the phenoxyl radical/phenol redox couple of phytocannabinoids as a diagnostic tool for analyzing their prooxidant action in the cell’
https://www.tandfonline.com/doi/abs/10.1080/10715762.2026.2695205

❤️ The Heart & Blood ❤️

For stir-fried hemp seeds in a rat model of a blood-deficiency syndrome, they helped with metabolic dysfunction & the gut microbiome potentially via the JAK1–STAT1 signaling pathway
‘Effects of stir-fried Hemp (Cannabis sativa L.) seed polysaccharides on blood deficiency syndrome in rats based on metabolomics and gut microbiota’
https://www.sciencedirect.com/science/article/abs/pii/S0963996926014754

In heart tissue, the combination of hyaluronic acid & nano-PEA with rutin protected heart cells by upregulating protective proteins, downregulating inflammatory mediators & decreasing apoptosis (programmed cellular suicide)
‘Hyaluronic acid and PEA-based Rutin-loaded nanoparticles as new cardioprotective tool against anthracycline-induced cardiotoxicity’
https://www.sciencedirect.com/science/article/pii/S0939641126001864

For treating high levels of lipids in the bloodstream, on creating a nanogel with the terpene beta-caryophyllene
‘Design and Optimization of Beta-Caryophyllene Nanoemulgel for Enhanced Antihyperlipidemic Activity: A Response Surface Approach’
https://pubmed.ncbi.nlm.nih.gov/42381134/

🍽️ The Guts, Nutrition & the Microbiome 🍽️

In extracts of Moroccan cannabis seeds given to female mice, they had lower cholesterol & higher LDL, with low acute toxicity
‘Moroccan Cannabis sativa L. seed chloroform extract: phytochemistry, acute toxicity, and metabolic-behavioral effects in mice’
https://www.notulaebiologicae.ro/index.php/nsb/article/view/12928

For dairy cows going through the transitions around birth, feeding them omega-3 fatty acids & the amino tryptophan upregulated genes for the enzymes FAAH (which breaks down anandamide) & MAGL (which breaks down 2-AG) while downregulating expression of the CB2 receptor
‘The effects of N-acetyl tryptophan and omega-3 feeding during the transition period on relative expression genes related to endocannabinoid system in adipose tissue of Holstein cows’
https://archrazi.areeo.ac.ir/article_134206_69c90264309ff7b927fdb97e41446c43.pdf

🩸 The Liver, Drug Interactions & Cannabinoid Metabolism 🩸

For Thai gut & liver patients after legalization, the use of cannabis was associated with modest but significantly increased levels of the liver enzyme ALT, whereas kratom was not
‘IDDF2026-ABS-0493 Cannabis and Kratom use and liver biochemistry in patients with gastrointestinal and liver diseases after legalization in Thailand’
https://gut.bmj.com/content/75/Suppl_2/A330.2.abstract

In people with cirrhosis, those diagnosed with cannabis use disorder had higher levels of intensive care admission, pneumonia, metabolic problems & all-cause mortality
‘Impact of cannabis use disorder on cirrhosis: analysis of usual practice using propensity score matching’
https://actaojs.org.ar/ojs/index.php/acta/article/view/592

For delta 8-THC, on identifying CYP2C9 as the liver enzyme that most likely breaks it down into its metabolites
‘Cytochrome P450–catalyzed hydroxylation of Δ8-tetrahydrocannabinol and implications for pharmacogenetics’
https://assets-eu.researchsquare.com/files/rs-9808179/v1_covered_98ea1223-28b0-40fe-bea7-6e9464234694.pdf?c=1781768950

💨 The Lungs 💨

In a mouse model of lung injury from a ventilator, inhibition of the MAGL enzyme (which breaks down the endocannabinoid 2-AG) reduced lung tissue injury via several pathways
‘B75-34 LEI-515-mediated Monoacylglycerol Lipase Inhibition Attenuates Ventilator Induced Lung Injury in Mice’
https://academic.oup.com/ajrccm/article/212/Supplement_2/aamag286.029/8712422

👀 The Eyes 👀

In people with central serous chorioretinopathy (buildup of fluid in the retina), the cannabis users showed a potential protective effect
‘Association of marijuana use with central serous chorioretinopathy’
https://iovs.arvojournals.org/article.aspx?articleid=2812307

In a rat model of glaucoma, activation of the CB1 receptor may increase the concentration of lactate in stressed cells
‘Cannabinoid 1 receptor agonism increases lactate release of stretch-stressed but not healthy optic nerve head astrocytes’
https://iovs.arvojournals.org/article.aspx?articleid=2814136

🖐️ The Skin & Topicals 🖐️

In a mouse model of psoriasis, a nanoemulsion of hemp seed oil lowered inflammatory responses & downregulated cytokine–cytokine receptor interaction as well as the NF-κB signaling pathway
‘Polysaccharide-based self-assembled hemp seed oil nanoemulgel ameliorates skin inflammation in a psoriasis mouse model’
https://www.sciencedirect.com/science/article/abs/pii/S0141813026030412

For wound healing, on creating a chitosan-based dressing with a sunflower oil nanoemulsion containing the terpene beta-caryophyllene
‘β-Caryophyllene-Loaded Sunflower Oil Nanoemulsion Incorporated into Chitosan Films for Wound Healing Applications’
https://pubs.acs.org/doi/full/10.1021/acsomega.6c02735

🎗️ Cancer & Chemotherapy 🎗️

In cancer survivors & cancer care providers, surveys found similar attitudes towards medical cannabis use but different awareness of risks
‘Perspectives on Cannabis Use among Cancer Survivors and Cancer Care Providers: Parallel Surveys’
https://link.springer.com/article/10.1007/s13187-026-02934-w

In people receiving palliative care for cancer, those with higher symptom burdens were more likely to report cannabis use
‘Self-Reported Cannabis Use and Symptom Burden Among Patients With Cancer Receiving Palliative Care’
https://journals.sagepub.com/doi/full/10.1177/10499091261466675

In a mouse model of estrogen receptor-positive breast cancer, the combination of THC & CBD suppressed tumor growth, especially at the highest doses
‘Preclinical antitumor evaluation of a tetrahydrocannabinol and cannabidiol (1:6) cannabis extract in an MCF-7 xenograft model of estrogen receptor-positive breast cancer’
https://veterinaryworld.org/Vol.19/June-2026/17.pdf

In lung cancer cells, CBD reduced cell viability & enhanced the efficacy of the treatment drug paclitaxel, while reducing tumor growth in a mouse model
‘Cannabidiol induces apoptosis and autophagy via STAT3 and NF-κB inhibition and synergistically enhances paclitaxel efficacy in non-small cell lung cancer’
https://www.sciencedirect.com/science/article/abs/pii/S094471132600721X

For bone cancers, the combination of CBD, THC, melatonin & cisplatin fragmented DNA, suppressed migration, lowered invasion, disrupted mitochondria (powerhouse of the cell) & upregulated apoptosis (programmed cellular suicide)
‘A selective low-dose cisplatin strategy enabled by melatonin and cannabinoids for targeting osteosarcoma and chondrosarcoma’
https://link.springer.com/article/10.1007/s00210-026-05551-y

In glioblastomas (the most aggressive brain cancer), the combination of CBN or CBG with melatonin caused potent, synergistic toxicity
‘Synergistic Antitumor Efficacy of Minor Phytocannabinoids and Melatonin Combinations in Human Glioblastoma Cell Lines’
https://www.preprints.org/frontend/manuscript/ebad2a42b4f1fd29012c9e9f5c59307f/download_pub

In glioblastomas (the most aggressive brain cancer), the combination of CBD & the drug temozolomide reduced their viability
‘Synergistic effects of Temozolomide and Cannabidiol on the Wnt/β-Catenin Signaling Pathway in Glioblastoma’
https://ijmcmed.org/browse.php?a_id=2729&sid=1&slc_lang=en

In melanoma cancer cells, cannabis extract enhanced the oxidative stress caused by UVB radiation
‘Cannabis sativa L. Extract Attenuates UVB-Induced Oxidative Stress and Rescues MITF Transcriptional Suppression in B16-F10 Melanoma Cell Line’
https://www.researchsquare.com/article/rs-9674603/v1

For breast cancer, on designing nanoparticles coated with immune cell membranes containing CBD & docetaxel
‘Quality by Design Development of Leukocyte Membrane-coated Nanoparticles Co-loaded with Docetaxel and Cannabidiol for Targeted Breast Cancer Therapy’
https://link.springer.com/article/10.1007/s12668-026-02668-5

💊 Synthetic Cannabinoids & Hemp-Derived Cannabinoids 💊

On detecting synthetic cannabinoids in blood with multi-structure recognition molecularly imprinted polymers
‘Synergistic integration of multi-structure recognition MIP with liquid-phase microextraction for trace analysis of synthetic cannabinoids in blood’
https://www.sciencedirect.com/science/article/abs/pii/S0026265X26019934

On screening for novel synthetic cannabinoids, on using differential pulse voltammetry
‘Electrochemistry meets designer drugs: Voltammetric determination of synthetic cannabinoids in herbal products and e-liquids’
https://www.croris.hr/crosbi/publikacija/prilog-skup/949848

In forensic toxicology, on the analytical challenges for semi-synthetic cannabinoids
‘Semi-Synthetic Cannabinoids in Forensic Toxicology and Public Health: Analytical Challenges, Emerging Detection Strategies, and Regulatory Implications’
https://www.mdpi.com/1424-8247/19/7/1022

A new book on synthetic cannabinoids
‘Synthetic Cannabinoid Receptor Agonists (SCRAs)’
https://boris-portal.unibe.ch/entities/publication/c7ddba6c-cc3f-4e63-b724-134e4c427b79

For the indazole-based synthetic cannabinoids, on the effects of different aliphatic (carbon chain) tails
‘Comprehensive Evaluation of Indazole-Based Synthetic Cannabinoid Receptor Agonists with Aliphatic Tail Groups: In Vitro Activities, Metabolic Stability, and In Vivo Pharmacokinetics’
https://pubs.acs.org/doi/abs/10.1021/acschemneuro.6c00294

🔬 Biochemical Discoveries & Research Tools 🔬

CBD found to interact with UDP-glucose dehydrogenase, an enzyme related to the extracellular matrix, signal transduction & cancer growth
‘Probe-Based Chemical Proteomics Identifies UDP-Glucose 6-Dehydrogenase as a Potential Cannabidiol-Interacting Protein’
https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.6c00586

For CBD, THC & CBN, on their quantum chemical parameters using density functional theory
‘Investigation of quantum chemical parameters of hemp (Cannabis sativa) components (CBD, CBN, THC) using density functional theory (DFT)’
https://pajes.pau.edu.tr/jvi.aspx?un=PAJES-85833&volume=

On creating the terpene beta-caryophyllene using a novel synthesis enzyme from Chinese mugwort
‘Highly efficient production of β-caryophyllene in Saccharomyces cerevisiae using a novel synthase from Artemisia argyi’
https://www.sciencedirect.com/science/article/pii/S2405805X26001092

A protocol for creating nano-micelles of CBD for experiments in mice
‘Protocol to prepare inclusion complex-enhanced cannabinoid nano-micelles for behavioral pharmacology and in vivo neurophysiology in mice’
https://www.sciencedirect.com/science/article/pii/S2666166726003035

Thanks.

- lex

PS: For this week’s adventuresome guitar of Chicago Blues & pinnacle of the West Side Sound, here’s ‘Presenting Magic Sam’. Dead tragically young of a heart attack at 32, Samuel Gene Maghett would surely have climbed the heights to stardom, but even in his short run, he left an indelible impression on how guitarists plays the blues. Born in Mississippi, Magic Sam moved to Chicago in his teens & began playing local blues clubs. He recorded for Cobra Records & you could already hear his rich new staccato fingerpicking in his debut single ‘All Your Love’. Unfortunately, he was drafted into the Army, where he served a 6-month prison sentence for desertion followed by a dishonorable discharge. Back in Chicago, he recorded with Chief Records with mournful tunes like a cover of Fats Domino’s ‘Every Night About This Time’ & then toured the US, Britain & Germany before signing on with Delmark Records. There he recorded two of his most important albums, ‘West Side Soul’ (including an iconic performance of the blues standard ‘Sweet Home Chicago’) & ‘Black Magic’, wide-ranging in their display of a new type of blues. At the 1969 Ann Arbor Blues Festival, he wowed an overflow crowd & allegedly, the legendary Stax Records was ready to sign him after his Delmark commitment finished. But in December of 1969, he complained of heartburn, collapsed & died, forever a king of the Westside blues.

Massive mental health gains for TSC + fibro, sleep, pain & cancer symptoms

Lex Pelger WhiteWhaleCreations — Mon, 06 Jul 2026 09:05:34 GMT

Cannabinoids & The People,
or; Drugs & Drug Wars

🌟 This week 🌟

(#hashtags for jumping to articles by searching for them with your browser)

CBD caused massive mental health gains for people with tuberous sclerosis complex (a disease of many benign tumors)
Cannabinoids for fibro, sleep, pain & cancer symptoms
Conflicting data on Parkinson’s shows help & no help
Harms: In youth using cannabis, it seemed to flatten their neurocognitive development (#youthharm)
#BDSM & your endocannabinoids!
#Sex! CBD to boost the sexual motivation & reverse the post-coital sexual inhibition in your rats
Preclinical: CBD for age-associated cognitive decline, THC for Alzheimer’s & activating the CB1 receptor for reduced sweating (?!)
Hot take on on the extractive nature of the cannabis industry in the global South (#extractive)
On ketamine for occupational burnout, sexual trauma & perinatal depression
War on Drugs: India home minister has a plan for a drug-free country by 2047 (#stupid)
Psychedelics: psilocybin for spinal cord injuries, DMT for cluster headaches & LSD for depression + how to stop bad trips
On psilocybin for calming your mangrove fish (#bursts)

[numbers for C&P#193: 9k words, ~17 minutes reading time, 133 papers]

Hello everyone,
Welcome to the 193^rd edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news + the War on Drugs, harm reduction & other psychoactives. Support this work with a paid subscription or by buying me a coffee.

If you purchase one of my canna-graphic novels based on Moby Dick, proceeds go to Americans for Safe Access to support medical cannabis patients.
For producing cannabinoid content, work with my company White Whale Creations: writing, science archives, social media, newsletters & podcasts.
As always, ask me anything!

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Follow along on Instagram to keep on learning or sign up for the monthly CHRI email (curated by me) to get just the best of clinical research & new reviews twice a month.

🎥 Lex’s new work 🎤

@CannabinoidsAndThePeople on YouTube, TikTok & LinkedIn
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(still working on my big EU, CBD & reproductive toxicity video…)

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(nothing new. Been playing work catchup. Summers are tough…)

And as always, at the bottom is the album of the week: a kid’s album of traditional tunes by Jerry Garcia & mandolinist David Grisman

💖 Ways to support this work 💖

https://www.cato.org/blog/wrong-war-sea

- Venmo: @Lex-Pelger

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📣 A request to spread the word 📣

This newsletter only spreads by word of mouth, so please share to friends & colleagues.

🍃 BEST OF CANNABINOID SCIENCE 🍃

(most of the phytocannabinoid data is here & most of the endocannabinoid data is in the ‘Canna-Science Archive’ at the bottom)

A great sleep article on cannabis as the double-edged sword of insomnia (glad to have a boots-on-the-ground pro-cannabis doctor sharing the negatives…)
https://www.phillyvoice.com/insomnia-cannabis-marijuana-sleep-risks/
I believe I’m going to turn this article into an educational video.

⚕️ Clinical ⚕️

In people with mental health problems from tuberous sclerosis complex (a disease of many benign tumors), 6 months of CBD improved eating, sleeping, irritability & manic behavior as well as took the number of people with severe behavior problems from 50% to 0%
Tuberous Sclerosis Complex (TSC)-Associated Neuropsychiatric Disorders (TAND) Outcomes Following Adjunctive Cannabidiol (CBD) Treatment: 6-Month Intermediate Analysis of the EpiCom Trial (S5.005)
https://www.neurology.org/doi/abs/10.1212/WNL.0000000000215638

In people with fibromyalgia, a 1:1 THC:CBD oil reduced pain, improved sleep quality & reduced fibromyalgia impact
Feasibility, Safety and Preliminary Efficacy of 1:1 THC:CBD Cannabis Oil for Fibromyalgia Symptoms: Results From a Randomised, Double-Blind, Placebo-Controlled Pilot Trial
https://onlinelibrary.wiley.com/doi/10.1155/prm/7311235

In the real-world use of cannabis oil, people reported better quality of life & sleep
Real-World Quality of Life and Sleep Outcomes in Patients Treated With THC-and CBD-Rich Cannabis Oil: A Cross-Sectional Study
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1862725/abstract

In the largest study from a state-run medical cannabis program on pain symptoms: people in Minnesota who used medical cannabis for four months reported improvements to life enjoyment, activity interference & pain scores
Benefits of Medical Cannabis in Patients With Pain Registered in the Minnesota Medical Cannabis Program
https://www.sciencedirect.com/science/article/pii/S0149291826001876

In people with cancer, a blinded study comparing 4 days of sublingual THC, CBD or placebo found that half getting cannabinoids achieved their primary outcome: Patient Global Impression of Change (predominantly sleep, tiredness & anxiety)
Comparing cannabinoid extracts for treating cancer-related symptoms: a randomized placebo-controlled, triple-blind aggregate n-of-1 clinical trial
https://www.medrxiv.org/content/10.64898/2026.05.31.26354558v1.full

For Parkinson’s disease, self-titrated medical cannabis oil caused improvements on the non-motor symptoms scale, the pain scale, the sleep scale, the urinary scale & the quality of life scale, with decreased nighttime urinary frequency
Exploratory Prospective Study of Self-Titrated Medical Cannabis for Nonmotor Symptoms in Parkinson’s Disease
https://journals.sagepub.com/doi/abs/10.1177/25785125261458680

For Parkinson’s disease & CBD, a meta-analysis of 11 trials found it did not improve any of the measured aspects
Efficacy of Cannabinoids on Parkinson’s Disease: An Updated Meta-analysis of Randomized Controlled Trials (P8-17.004)
https://www.neurology.org/doi/abs/10.1212/WNL.0000000000215479

For Parkinson’s disease & cannabis, a meta-analysis of 10 trials found no help
Medical Cannabis in the Treatment of Non-motor and Motor Symptoms in Parkinson’s Disease: A Systematic Review and Meta-analysis (P6-17.013)
https://www.neurology.org/doi/abs/10.1212/WNL.0000000000216378

In children with drug-resistant epilepsy, a French observational study found significant improvements to behavior, well-being, cognition, physical activities & social interaction as well as a 50+% seizure reduction in two-thirds of patients
Impact of Cannabidiol on Quality of Life and Seizure Control in Children with Drug-Resistant Epilepsy: A Retrospective Observational Study
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6695991

In treatment-resistant epilepsies, a meta-analysis found CBD significantly improved the rates of seizure freedom & responder rates
Cannabidiol in Refractory Epilepsy: Meta-analysis of Seizure Freedom and Responder Rates Across Syndromes (P8-11.001)
https://www.neurology.org/doi/abs/10.1212/WNL.0000000000213060

In kids with epilepsy, CBD isolate not only reduced their seizure frequency but also their anxiety symptoms, with greater blood levels of the endocannabinoid 2-AG associated with greater reductions in anxiety symptoms
Preliminary Prospective Study of Pharmaceutical-grade Cannabidiol for Seizure Frequency and Comorbid Anxiety Symptoms in Pediatric Epilepsy: Associations with Circulating Endocannabinoids and Related Lipid Biomarkers (P3-8.005)
https://www.neurology.org/doi/abs/10.1212/WNL.0000000000215478

In people with epilepsy, CBD combined well with a ketogenic diet & was more effective when CBD was initiated first
Combination Cannabidiol and Ketogenic Diet Therapy in Epilepsy (P3-10.005)
https://www.neurology.org/doi/abs/10.1212/WNL.0000000000215194

For the New York cannabis program, ~30% said they might discontinue certification & said they prefer adult-use dispensaries because of the proximity, greater availability & preferred product types
Patient Experiences and Access Barriers in the New York State Medical Cannabis Program: Findings from Two Consecutive Cross-Sectional Surveys, 2023 to 2024
https://www.sciencedirect.com/science/article/pii/S0149291826001335
“Geographic access became more limited in 2024 with the closures of 10 medical dispensaries, leaving 32 medical dispensaries operating statewide. In 2024, 48% of respondents reported travel times <30 minutes to a medical dispensary, 31% reported between 31 and 60 minutes, and 5% used delivery services. Cost was one of the main barriers with 49% of all patient respondents reporting they are unable to afford sufficient product to manage symptoms.”

In people engaging in BDSM, this thesis project found higher levels of endocannabinoids, similar to a runner’s high (#BDSM)
The biological mechanisms associated with BDSM interactions in dominants and submissives
https://repository.uantwerpen.be/docman/irua/764508motoMe7

For humans co-using CBD & alcohol, there were no significant changes in the alcohol effects or cravings
Safety of Co-Administered Cannabidiol (CBD) and alcohol: a Phase I study
https://link.springer.com/article/10.1186/s42238-026-00457-1

For memory in habitual cannabis users, they had faster response times but decreased accuracy
Cognitive Effects of High-potency Cannabis Intoxication on Prospective Memory in Habitual Users (P5-7.014)
https://www.neurology.org/doi/abs/10.1212/WNL.0000000000217266

For edibles & heart rate, unlike inhaled cannabis, they caused only a small non-clinically significant decrease in heart rate
An Exploration of Heart Rate Response and Blood Tetrahydrocannabinol (THC) Levels to Commercially Available Cannabis Edibles by Dose
https://www.researchsquare.com/article/rs-9762624/v1

For neuroblastomas (the most common & lethal solid tumor in children), two case reports on the combination of cannabis, melatonin & oxygen-ozone therapy causing weight recovery & the complete disappearance of detectable disease
Medical cannabis, melatonin and oxygen-ozone therapy for neuroblastoma: two case reports
https://www.researchsquare.com/article/rs-9651000/v1

In people with cannabis use disorder, a survey about their stigma found it to be felt most strongly in adolescents
Stigma toward individuals with cannabis use disorder across age groups: associations with familiarity and sociodemographic characteristics
https://link.springer.com/article/10.1186/s12954-026-01491-1

For reducing cannabis secondhand smoke exposure in children, in-home air quality monitoring “supported risk awareness, promoted family dialogue, and coincided with reductions in in-home smoking around children”
Using In-Home Air Quality Monitoring to Reduce Cannabis Secondhand Smoke Exposure in Children: Quantitative Pilot Feasibility Study
https://formative.jmir.org/2026/1/e89820/

📑 Reviews 📑

For arthritis & CBD, a review of the clinical & preclinical evidence of its painkilling potential being “comparable to other types of medications with low to no detrimental effects”
Therapeutic Potential of Cannabidiol for Pain Management in Arthritis: Evidence from Clinical and Preclinical Studies
https://www.authorea.com/doi/pdf/10.22541/authorea.15004664/v1

For CBD & inflammation, a great review on how it targets the NLRP3 inflammasome (love the charts!)
Cannabidiol as a modulator of NLRP3 inflammasome: Mechanistic insights and therapeutic potential
https://www.sciencedirect.com/science/article/pii/S2707368826000361

In bruxism (tooth grinding, mostly at night), a review on the potential of targeting the endocannabinoid system
ENDOCANNABINOID SYSTEM MODULATION IN BRUXISM: A NEUROBIOLOGICAL HYPOTHESIS AND TRANSLATIONAL MODEL OF ECS-TARGETED INTERVENTION
https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1854001/abstract

In ovarian cancer & glioblastoma cells, a review of how THC, CBD & CBG use a variety of mechanisms to cause cell death
Insight into the mode of action of phytocannabinoids against ovarian cancer and glioblastoma
https://www.sciencedirect.com/science/article/pii/S2667031326000588
“These include the following pathways: phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (AKT)/ mammalian target of rapamycin (mTOR), Wnt, rat sarcoma virus (RAS)– rapidly accelerated fibrosarcoma (RAF)–MAPK kinase (MEK)–extracellular signal-related kinase (ERK) (MAPK/ERK), c-Jun N-terminal kinase (JNK)/p38 mitogen-activated protein kinase (MAPK), transforming growth factor β (TGF-β) and Ras homolog (Rho)/Rho associated coiled-coil containing protein kinase (Rock) pathways.”
(I can’t wait to illustrate these with my Moby Dick metaphor of phytocannabinoid elephants tearing through vicious cancer cells like dwarves through a horde of orcs & goblins…)

In canine cancers, a review of the potential of CBD
Potential antitumor effect of cannabidiol (CBD) in canine oncology: a systematic review
https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1800410/full

In the central nervous system, a review on the role of the CB2 receptor (with a lovely chart)
The relevance of cannabinoid receptor 2 in the central nervous system: an update over the last 3 years
https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2026.1882543/full

For neurodegenerative diseases, a review of inhibiting the enzyme MAGL (which breaks down the endocannabinoid 2-AG)
Recent advances in neurodegenerative diseases therapeutics: The inhibition of monoacylglycerol lipase strategy
https://www.sciencedirect.com/science/article/abs/pii/S0306452226003866

For opioid use disorder & chronic pain, a review on targeting the endocannabinoid system
Therapeutic activation of the endocannabinoid system for opioid use disorder, chronic pain, and cancer-related pain: a review of current evidence
https://www.tandfonline.com/doi/abs/10.1080/14728222.2026.2690138

For the effects of cannabinoids on the blood vascular system, a review of the role of PPARgamma (a nuclear receptor that regulates genetic transcription) & the need for more work to validate its potential responsibility for vasodilation (nice graphical abstract)
Reassessing the role of PPARgamma in vascular effects of cannabinoids: A critical appraisal
https://www.sciencedirect.com/science/article/pii/S1537189126000911

⚠️ Harms ⚠️

For cannabis adverse drug reactions in the World Health Organization’s VigiBase, the most predominantly reported were psychiatric & nervous system disorders with gut, lung & heart disorders less common
Cannabis and Cannabinoid-Related Suspected Adverse Drug Reactions: Global Patterns and Cross-National Analysis Based on VigiBase® Data
https://link.springer.com/article/10.1007/s40263-026-01303-x

In a cohort of youth using cannabis, they had likely pre-existing better cognitive performance during late childhood but later reduced improvement or flattened neurocognitive trajectories for memory, processing speed, inhibitory control, visuospatial processing & language (#youthharm)
Longitudinal neurocognitive trajectories in a large cohort of youth who use cannabis: combining self-report and toxicology
https://www.nature.com/articles/s41386-026-02395-1

In adults with depressive disorders, they had a ~60% greater risk of developing cannabis use disorder
Risk of Cannabis Use Disorder Among Adults with Pre-Existing Depression: Evidence from the U.S. NESARC-III (2012–2013)
https://link.springer.com/article/10.1007/s11469-026-01684-6

For cannabis-induced psychosis, a case report of recurrent psychotic episodes with aggression, irritability, grandiose delusions, self-talk, insomnia, mood instability & impaired social functioning, with help from abstinence & pharmacological treatment
CHRONIC CANNABIS USE PRESENTING WITH NEUROCOGNITIVE IMPAIRMENT AND CANNABIS-INDUCED PSYCHOSIS: A CASE REPORT AND INTEGRATED TREATMENT APPROACH
https://www.researchgate.net/publication/407043066_CHRONIC_CANNABIS_USE_PRESENTING_WITH_NEUROCOGNITIVE_IMPAIRMENT_AND_CANNABIS-INDUCED_PSYCHOSIS_A_CASE_REPORT_AND_INTEGRATED_TREATMENT_APPROACH

A case report of a death from bleeding into the lungs potentially linked to cannabis
Cannabis Smoking Induced Diffuse Alveolar Hemorrhage in a Young Adult
https://journals.vertexpub.com/index.php/amme/article/view/32

A case report of psoriasis potentially due to cannabis use
Drug-induced psoriasis secondary to cannabis use
https://www.sciencedirect.com/science/article/pii/S2352512626003693

For cannabis & later psychosis, a review found “credible evidence that daily cannabis use is a contributory cause of psychosis”, but less certain associations with bipolar disorder, depression, anxiety & suicidality
Relationships between cannabis use and mental disorders: assessing the coherence of evidence from studies with different methodologies
https://www.sciencedirect.com/science/article/pii/S2215036626000866

For bipolar disorder with cannabis use disorder, a review found higher levels of manic episodes, rapid cycling, psychosis & earlier bipolar disorder onset
Clinical Phenomenology of Bipolar Disorder With Substance Use Disorders: A Systematic Review
https://pubmed.ncbi.nlm.nih.gov/42286971/

In a rat model of prenatal & lactation exposure to THC, this thesis project found that there were disruptions in the offspring’s maturation of sleep & breathing
Early-Life Exposure to Delta-9-Tetrahydrocannabinol (THC) Disrupts the Maturation of Sleep and Breathing
https://umontreal.scholaris.ca/server/api/core/bitstreams/72443eb9-ef47-4165-a2e7-e9786352b4f4/content

In a zebrafish model of prenatal exposure to THCV, this thesis project found stage-dependent differences in uptake & changes to neural & behavioral processes
Windows of Developmental Susceptibility to Tetrahydrocannabivarin (THCV) Reveal Stage-Dependent Morphological and Biological Effects
https://egrove.olemiss.edu/cgi/viewcontent.cgi?article=4740&context=hon_thesis

In the lung cell macrophages (white blood cells that eat invaders), cannabis smoke extract caused metabolic stress & impaired polarization but did not impair their phagocytosis (eating invaders)
Cannabis Smoke Extract Impairs Alveolar Macrophage Antimicrobial Functions
https://www.mcgill.ca/ose/files/ose/2-23_-_albert.pdf

🐁 Preclinical 🐁

In a male rat model of sexual inhibition, CBD acutely caused sexually satiated rats to increase their sexual motivation & reverse their sexual inhibition, while chronically, CBD had no negative effects on male sexual behavior (#sex)
Cannabidiol has facilitative effects on sexual motivation of sexually inhibited male rats
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6819584

In a mouse model of age-associated cognitive decline, CBD reversed the mood & memory deficits, restored levels of cannabinoid receptors, lessened inflammatory signaling & normalized neurotransmitter balance in the medial prefrontal cortex
Cannabidiol rescues age-associated cognitive decline in mouse model
https://www.biorxiv.org/content/10.64898/2026.04.12.711942v1.abstract

In a rat model of Alzheimer’s disease, THC improved cognitive performance, prevented cell loss & increased markers of neurogenesis (the creation of new brain cells)
Delta-9-tetrahydrocannabinol delineates D-galactose and aluminium chloride-induced cognitive dysfunction and neurodegeneration in the hippocampus of the Wistar rat model
https://link.springer.com/article/10.1007/s12038-026-00599-7

In a mouse model of a drug-resistant severe childhood epilepsy, CBD reduced seizures & infantile spasms
Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3+/D120N mouse model of Lennox-Gastaut syndrome
https://onlinelibrary.wiley.com/doi/pdf/10.1002/epi4.70289

In a mouse model of sweating, activating the CB1 receptor with anandamide reduced sweating
Don’t Sweat It: Cannabinoid CB1 Receptors Reduce Sweating in a Mouse Model
https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202601143R

In a tissue model of Parkinson’s disease, CBD caused neuroprotection via increasing the anti-oxidative activities of transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2)
Cannabidiol confers neuroprotection against 6-OHDA toxicity by rescuing Nrf2 proteostasis and preserving mitochondrial integrity
https://www.biorxiv.org/content/10.64898/2026.05.07.723512v1.abstract

In a tissue model of cartilage inflammation, extracts of hemp polyphenols protected the cartilage & caused anti-inflammation
Anti-inflammatory and Cartilage-sparing properties of Hemp Polyphenol Extract in an in-vitro model of cartilage inflammation
https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2026.1862027/abstract

For a proprietary formula of CBN, a safety study in tissue & rats found no toxicity
Investigation into the oral toxicity profile of TruCBN™
https://www.sciencedirect.com/science/article/pii/S2214750026000983

🆕 Novel Studies 🆕

(my grab bag section for stuff I haven’t quite seen before)

On a new drug (SYT-510 by Synendos Therapeutics) that inhibits the reuptake of the endocannabinoids anandamide & 2-AG, it was found effective in animal models of anxiety, compulsive behavior, drug-induced muscle spasticity, seizure, pain & multiple sclerosis
SYT-510, the Clinical Candidate of First-in-class Selective Endocannabinoid Reuptake Inhibitors, Demonstrated Efficacy in Preclinical Models of Anxiety, Spasticity, Seizure, Pain and Neuroinflammation (P11-7.009)
https://www.neurology.org/doi/abs/10.1212/WNL.0000000000216773
Yes, but they’re brave in going after an endocannabinoid reuptake inhibitor. Famously, in the French trial of BIA 10–2474 (an inhibitor of FAAH, the enzyme that breaks down anandamide), the drug at its highest dose killed one person in the study & caused irreversible brain damage in 4 more.

On the Australian company Avecho & their CBD soft-gel capsule for insomnia (ongoing phase III trial)
https://cannabinoidpipelineinsights.substack.com/p/insomnia-and-cannabinoids-avecho

For the Mayaro virus (a mosquito-borne illness of South America), activating the CB1 receptor in macrophages (our white-blood cell that kills microorganisms) decreased viral replication & downregulated inflammation
WIN 55,212-2 Modulates Antiviral, Inflammatory, and ER Stress Responses in Mayaro Virus-Infected Macrophages: Insights from RNA-Seq and In Vitro Studies
https://www.mdpi.com/1999-4915/18/6/662

For the measles vaccine, the rare cannabinoids Cannabichromevarin (CBCV) & Cannabichromenic acid (CBCA) stabilized the proteins
Identification of cannabichromevarin as a potent stabilizer of the measles virus prefusion F protein: structural insights from long-timescale molecular dynamics
https://www.nature.com/articles/s41598-026-50199-6

📰 US Headlines & Fav Articles 📰

In New York, the state launches an educational hub for healthcare providers & public health professionals called the Center of Excellence for Cannabis Care and Health Equity
https://spectrumlocalnews.com/nys/central-ny/news/2026/06/25/new-york-state-launches-center-for-cannabis-care-and-health

An Atlantic article on parenting & cannabis
https://www.theatlantic.com/family/2026/06/gardening-moms-weed-parenting/687518/
Overall, I’d have to say I don’t like it. The writer is trying to see both sides & acknowledges that some people use it well & some are being neglectful & getting high all day in the garage, but she shares a fairly silly quote from a researcher saying there’s no evidence on cannabis helping with anxiety or depression — and the final line is one that really pushed me over the edge into deciding I didn’t like this article: “In the quest to be the best, a mother is asked to abandon herself and her own emotional responses—and for some moms, apparently, the only way through is to feel a little less.”

History Corner: 900s: In the Islamic Golden Age, a review of the uses of cannabis (oh my do I wish this one wasn’t behind a paywall...)
Ethnopharmacological Uses of Cannabis in the Arabic–Islamic Golden Age from the IXth to the XVIth Century CE
https://journals.sagepub.com/doi/10.1177/02780771261458775

🌐 International News 🌐

In France, regulators submitted their long-awaited decree of rules on the reimbursements for medical cannabis to the French Council of State for approval (their medical cannabis pilot program began when my 2^nd child was born. We celebrated her 5^th birthday last week. And I’m hoping to enjoy adult-use cannabis here by the time she has her own 5-year-old)
https://www.newsweed.fr/en/france-proposes-decree-on-medical-cannabis/

In Canada, the hemp industry called for raising the limit for THC to 1%, to eliminate most licensing requirements & allow for the unrestricted sale of hemp flowers & biomass
https://hemptoday.net/canadian-hemp-industry-presses-regulators-for-1-thc-limit-other-sweeping-reforms/
And in Alberta, they have an industry-leading model for adult-use sales at music festivals
https://stratcann.com/insight/albertas-festival-cannabis-model-is-leading-the-industry/

In Israel, they reopened their investigation into Canadian companies dumping medical cannabis into their market
https://stratcann.com/news/israel-reopens-dumping-investigation-into-canadian-medical-cannabis/

In Chile, the decriminalization of personal use cannabis is now on hold
https://cannabislaw.report/the-decriminalization-of-cannabis-for-personal-consumption-on-hold-in-chile/

In Morocco, on how the traditional farmers are getting locked out of the growing industry
https://hightimes.com/culture/theres-a-mountain-in-morocco-where-everyone-grows-hash-the-locals-call-it-the-temple-of-the-plant-the-government-called-it-illegal/
Beware the one false fact: that cannabis is known to have originated in India. In fact, few researchers believe that & the best current guess is the steppes of Central Asia, though arguments can be made for China (who was known since antiquity as the Land of Mulberry & Hemp). But no one really knows, and it’s doubtful we’ll ever really know.
If I die & get to ask God a few questions, the origin of cannabis will be one of them. For most other things, I feel fairly at peace.

For illicit cannabis growers in Ghana, a survey of their issues, concerns & ideas
Opinions of Illicit Cannabis Growers on the Industrial Legalization of Cannabis in Ghana: An Exploratory Qualitative Study
https://journals.sagepub.com/doi/pdf/10.1177/29768357261458735

In Algerian drug policy, on the history of their approaches
Contemporary Criminal Policy for the Prevention of Narcotic Drugs and Psychotropic Substances in Algerian Law
https://asjp.cerist.dz/en/article/297334

In Sierra Leone’s rise of Kush (a synthetic cannabinoid compound), a call to use the health community engagement insights from their 2014 Ebola response
Sierra Leone’s Polydrug Crisis is an Epidemic of Structural Violence: Community Engagement During the Ebola Response May Offer a Viable Framework for Communication Interventions
https://www.tandfonline.com/doi/pdf/10.1080/10810730.2026.2689086

⚖️ Business, Laws & Education ⚖️

Powerful take on the extractive nature of the cannabis industry in the global South (#extractive)
https://www.talkingdrugs.org/cash-crop-the-extractive-cannabis-industries-of-the-global-south/
Also, I’m buying his ‘The African Roots of Marijuna’.

For budtenders & prenatal cannabis risk messaging in California, those in more socially vulnerable areas were more likely to provide safety-affirming or lower-risk messaging
Social vulnerability and prenatal cannabis safety messaging from cannabis retailers in California
https://www.sciencedirect.com/science/article/abs/pii/S0376871626002206

For consumer CBD products, a label integrity study found that only 30% met the 10% accuracy threshold, with oils, tinctures & edibles doing better than vapes & topicals
Label integrity of cannabidiol consumer products: A matrix-specific review of accuracy, contaminants, and regulatory gaps (2017–2025)
https://www.sciencedirect.com/science/article/pii/S1874390026000947

🚗 Driving 🚗

For promoting safe driving behaviors among cannabis users, an analysis of messaging facts & impairment had higher ratings on outcomes, but high-risk drivers were less responsive
Tailoring the message: Communication strategies to promote safer driving behaviors among cannabis users
https://www.tandfonline.com/doi/full/10.1080/15389588.2026.2680240
Apparently the definition of ultra-high-risk is feeling safe to drive within one hour of cannabis use.

🚓 The War on Drugs 🚓

Your best 3-minute breakdown on why the War on Drugs has never worked & will never work (including these new US targeted strikes on cocaine vessels)

On how Trump’s war against narco-terrorism resembles Reagan’s use of it as a tool against leftists
https://theconversation.com/trumps-narco-terrorism-war-in-latin-america-evokes-reagan-then-as-now-its-more-about-fighting-leftists-than-drug-runners-284287

In Mexico, some politicians are becoming informants for the US about the links of their colleagues to cartels
https://www.nytimes.com/2026/06/27/world/americas/mexican-officials-us-informants.html

On the erasure of indigenous communities by narcotraffickers
https://www.truthdig.com/photo-essays/after-resisting-narco-groups-mexican-indigenous-towns-are-being-erased/

In India, in perhaps the stupidest thing I’ve ever heard, the home minister Amit Shah released his 3-year plan for making India drug-free by 2047 (#stupid)
https://www.hindustantimes.com/india-news/shah-unveils-3-yr-plan-to-end-drug-trade-101782498038791.html

In Paraguay, the seizure of a jet with cannabis aboard owned by a Mr. Beast winner highlighted the increased flow of high-potency US cannabis down to Paraguay, usually the supplier of low-grade cannabis to the rest of South America
https://insightcrime.org/news/what-a-drug-bust-involving-a-mrbeast-winner-says-about-latams-marijuana-trade/

As security collapses along the Bangladesh & Myanmar border, there’s been a huge surge in the seizure of methamphetamine & stimulant pills
https://eng.mizzima.com/2026/07/01/35850

How war & poverty are driving Myanmar’s drug crisis
https://www.ucanews.com/news/how-war-and-poverty-are-driving-myanmars-drug-crisis/113825

In Iran, a 70-year-old Afghan national was executed by hanging for drug offenses
https://thekabultribune.com/en/0009578

In Malaysia, 70% of prisoners are there for drug-related reasons
https://www.thestar.com.my/news/nation/2026/06/23/seven-in-10-prison-inmates-held-for-drug-offences-dewan-rakyat-told
This is one of the reasons we need to end the War on Drugs.

In El Salvador, 6+ tons of cocaine seized from 2 vessels in the Pacific
https://cannabislaw.report/el-salvador-seizes-over-six-tons-of-cocaine-in-pacific-ocean/

Off the coast of Portugal, four tons of hashish seized
https://cannabislaw.report/gnr-seize-around-four-tonnes-of-hashish-off-coast-of-setubal-arrest-four/

In Morocco, 2.4 tons of hashish seized after a maritime chase
https://cannabislaw.report/morocco-police-seize-over-2-4-tons-of-cannabis-in-major-drug-bust-near-kenitra/

In a submerged grotto of an Italian island, 40 kg of hashish seized after its discovery by Italian police divers
https://cannabislaw.report/police-discover-420k-of-hashish-in-cave-on-luxury-italian-island/

In Hong Kong, 12 kg of cannabis seized with an estimated street value of $2.1M (?!)
https://cannabislaw.report/hong-kong-customs-seizes-suspected-cannabis-buds-at-airport-2/

In Anchorage, Alaska, the wild story of the local attorney continues as he pled guilty to drug charges tied to a massive cartel ring
https://cannabislaw.report/suspended-anchorage-attorney-pleads-guilty-in-federal-drug-case-tied-to-massive-alaska-cartel-ring/

WoD Research

The United Nations Office on Drugs and Crime published their ‘World Drug Report 2026’ & they ain’t happy about everybody moving towards cannabis liberalization
https://www.unodc.org/unodc/en/data-and-analysis/world-drug-report-2026.html

In Indonesia, on using the restorative justice approach for people with substance use disorders
THE RELEVANCE OF THE RESTORATIVE JUSTICE APPROACH TO THE PROTECTION OF DRUG ABUSE VICTIMS IN THE MODERN LEGAL SYSTEM IN MAKASSAR CITY
https://revista.domhelder.edu.br/index.php/veredas/article/view/6880

In Mexico, ethnographic interviews on displacements due to narco-violence
Displacement, Deportation, and Devastation: The Evolving Geography of Narco-Violence in Mexico / Desplazamiento, deportación y devastación: la evolución de la geografía de la narcoviolencia en México
https://muse.jhu.edu/pub/15/article/992795/summary

🛡️ Harm Reduction News 🛡️

In Australia, the life-saving drug Sublocade for opioid use disorder will be pulled at the end of the year, though the alternative long-acting injectable buprenorphine brand Buvidal will still be available
https://www1.racgp.org.au/newsgp/professional/lifesaver-opioid-disorder-treatment-pulled-from-au
https://www.theguardian.com/australia-news/2026/jul/01/life-saving-drug-for-people-with-opioid-dependency-to-be-pulled-from-australia-by-end-of-year

In Canada, a chilling story of the government using its power to shut down a harm-reduction center with a smear campaign about human & drug trafficking
https://drugdatadecoded.ca/out-in-the-cold-part-1-surveillance-smearing-and-shutdown-of-a-harm-reduction-shelter-copy/

Harm Reduction Research

For substance use disorders in the US, on their global disease burden over the last 40 years & forecasts for the next 25 years
National- and state-level burdens of substance use disorders in the USA, 1990-2023, with forecasts up to 2050: Global Burden of Disease Study 2023
https://www.cell.com/med/abstract/S2666-6340(26)00142-X

For take-home naloxone in Europe, if people had it & saw an overdose, they were willing & able to safely & effectively administer it in a timely manner
Overdose reversal through peer intervention: findings from the Naloxone Prospective Outcome Research Study (NalPORS) on the effectiveness of overdose response by people who use opioids in the UK and Sweden: NalPORS
https://kclpure.kcl.ac.uk/ws/portalfiles/portal/376811630/26-0165_NM_10.06.26.pdf

For public health vending machines on American Indian reservations, interviews found that participants reported enhanced access to health-promoting supplies in a low-key manner that minimized stigma
Exploring Perspectives About Public Health Vending Machine Implementation on an American Indian Reservation in the Northern Midwest, United States
https://link.springer.com/article/10.1007/s10461-026-05182-7

When Pueblo, Colorado banned syringe distribution, an analysis found sustained decreases in the distribution of naloxone & syringes, while the repeal of the ban did not change the levels of syringe litter
Association between a citywide ban on syringe distribution and provision of harm reduction services
https://www.sciencedirect.com/science/article/pii/S277272462600051X

🍄 Psychoactives, Psychedelics & Plant Medicines 🍄

Interview with a Catholic exorcist on demons, parts work & psychedelics
https://www.ecstaticintegration.org/p/catholic-exorcism-expert-on-demons

A new documentary from the CBC on MDMA kingpin Michael Clegg: ‘Prophet of Ecstasy’
https://www.cbc.ca/documentaries/ecstasys-origin-story-how-a-would-be-priest-introduced-mdma-to-the-world-9.7183176

For DXM (the psychoactive active ingredient of cough syrup), a review of dosage of effects
Dextromethorphan Beyond the Cough: Exploring Its Psychedelic Potential: A Systematic Review
https://link.springer.com/article/10.1007/s40263-026-01305-9

The DEA plans to schedule 3 synthetic kratom derivatives: mitragynine pseudoindoxyl (MP), dihydro-7-hydroxymitragynine (MGM-15) & a 9-fluoro derivative of 7-OH (MGM-16)
https://www.dea.gov/press-releases/2026/07/01/dea-temporarily-schedule-7-oh-and-related-substances-protect-public
https://www.hhs.gov/press-room/hhs-fda-support-dea-7-oh-scheduling.html

Psychedelics & MDMA

On psilocybin for spinal cord injury, a case series of 3 people with improved motor function, activation of new muscles & rapid strength gains with enhanced proprioceptive awareness as well as psychological benefits for well-being, enhanced motivation for recovery & improved adjustments to their post-injury reality
Case series of psilocybin self-medication for spinal cord injury
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6718771

For DMT & cluster headaches, a survey found it had a rapid abortive effect
DMT use in Cluster Headache: Interim Analysis of an International Survey (S23.003)
https://www.neurology.org/doi/abs/10.1212/WNL.0000000000215894

In psilocybin for adults with alcohol use disorder, a single treatment helped decrease drinking at one month, but returned to baseline within 4 months
Safety and Efficacy of Psilocybin-Assisted Therapy for Alcohol Use Disorder: Open-Label Extension of a Phase II Randomized Controlled Trial
https://osf.io/preprints/psyarxiv/gf7bq_v1

For depression, new results from a phase 3 trial of an oral LSD tablet caused “rapid, robust, and durable relief”
https://ir.definiumtx.com/news-events/press-releases/detail/232/definium-therapeutics-announces-positive-topline-results-from-phase-3-emerge-study-of-dt120-orally-disintegrating-tablet-odt-in-major-depressive-disorder
https://www.statnews.com/2026/06/22/definium-lsd-dt120-major-depression-phase-3-data/

On psilocybin for treatment-resistant depression, this triple-blinded study found 25 mg of psilocybin with psychotherapy caused reduced depressive symptoms, though not reaching the primary endpoint of 50% reduction of scores
Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2846478

For stopping psychedelic trips, a review of the candidate medications
Trip killers: Addressing a critical knowledge gap in psychedelic research
https://journals.sagepub.com/doi/10.1177/02698811261431056

For music in psychedelic therapy, a review of 25 articles on study protocols
Music Playlist Use in Clinical Trials of Psychedelic Assisted Psychotherapy: A Systematic Review
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jclp.70167

On integrating psychedelics into the NHS, on a model for real-world implementation of psilocybin
Psychedelics in NHS services: exploring a model for real-world implementation of psilocybin
https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/psychedelics-in-nhs-services-exploring-a-model-for-realworld-implementation-of-psilocybin/BED0E750723C1C698C0F6BF0A1D6F178

On MDMA for PTSD, a review of 14 studies found help for PTSD symptoms, dissociative symptoms & improved functioning but no clear benefit for depression
Efficacy of 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy for posttraumatic stress disorder: A systematic review and meta-analysis of clinical and functional outcomes
https://www.sciencedirect.com/science/article/pii/S0924977X2600043X

On psychedelics for anxiety, a review of 18 studies found anti-anxiety effects, but also anxiety-inducing & null effects
Serotonergic Psychedelics as a Potential Therapeutic Strategy for Anxiety, A Systematic Review
https://osf.io/preprints/psyarxiv/7xfek_v1

On the mechanisms of psychedelics for depression, a review of their GPCR signaling, transcription factors (which regulate genetic transcription) & effects on glutamate (the brain’s most common excitatory neurotransmitter)
Antidepressant effect of psychedelic compounds and mechanisms underlying the G protein-coupled receptors activation psychedelics: Antidepressant action and GPCR signaling
https://www.sciencedirect.com/science/article/pii/S0014299926005182

For treating substance use disorders in the Czech Republic with psychedelics, a review of the evidence & regulatory developments
Integrating psychedelic-assisted psychotherapy into addiction care in the Czech Republic: Clinical evidence, safety, and regulatory developments
https://www.akjournals.com/view/journals/2054/aop/article-10.1556-2054.2026.00514/article-10.1556-2054.2026.00514.xml

In the mangrove Rivulus fish (both social & aggressive), psilocybin decreased their activity levels & their swimming bursts (an aggressive behavior) (#bursts)
The magic of mushrooms: psilocybin influences behavior in the mangrove rivulus fish, Kryptolebias marmoratus
https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2026.1767175/full

Ketamine

In people with occupational burnout, at-home ketamine caused three-quarters of them to no longer meet the classification conditions
Burnout Symptom Outcomes During At-Home Ketamine-Assisted Therapy: A Real-World Retrospective Analysis of 395 Adults
https://www.researchsquare.com/article/rs-10020276/v1

For off-label ketamine in NYC, there were 233 clinics, with one-third advertising at-home use for depression & substance use disorder while only half listed a medical doctor on their team
Monitoring of Clinics That Use Direct-to-Consumer Advertising for Off-Label Ketamine in the New York Metropolitan Area: A Cross-Sectional Systematic Web Search
https://onlinelibrary.wiley.com/doi/abs/10.1111/fcp.70095

In people with PTSD from sexual trauma, a review on the use of ketamine
Efficacy of intra-operative ketamine in attenuating emergence agitation in patients with sexual trauma related post-traumatic stress disorder
https://connectsci.au/cj/article/doi/10.1071/CJ25013/274278/Efficacy-of-intra-operative-ketamine-in

For ketamine & perinatal depression, a review of its antidepressant effects & their mechanisms
The Mechanistic Basis of Ketamine’s Effectiveness in Reducing Perinatal Depression
https://jmsgr.tamhsc.edu/the-mechanistic-basis-of-ketamines-effectiveness-in-reducing-perinatal-depression/

Kratom

For kratom in Thailand, an analysis found that after legalization in 2021, kratom-related calls to the poison center increased 2.5x
Frequency of kratom-related poison center calls before and after kratom legalization in Thailand: current trends
https://www.tandfonline.com/doi/full/10.1080/15563650.2026.2675033

For dyspigmentation (blueing) of the skin caused by kratom, a case report of treating it with a laser
Management of Kratom-induced Dyspigmentation with the Picosecond 1064nm Laser
https://www.sciencedirect.com/science/article/pii/S2352512626003607

For kratom, on how the breakdown products moved through humans
Unveiling the metabolic signatures of kratom use in humans via NMR-based blood plasma metabolomics
https://www.sciencedirect.com/science/article/abs/pii/S0963996926014262

On a kratom patch for local inflammation
Transdermal delivery and anti-inflammatory efficacy of Mitragyna speciosa extract transdermal patch for local inflammation management: in vitro, ex vivo, and in vivo investigations
https://link.springer.com/article/10.1007/s13346-026-02174-x

🍃 The Plant & its Products 🍃

🌱 Growing 🌱

On the sustainable cultivation of hemp, a new book
Achieving sustainable cultivation of hemp
https://www.taylorfrancis.com/books/edit/10.1201/9781003764533/achieving-sustainable-cultivation-hemp-jay-stratton-noller

For aphids who feed on cannabis, an analysis across the season of the species involved
Aphid-parasitoid interactions and their contribution to biological control in medicinal Cannabis sativa L. crops
https://pubmed.ncbi.nlm.nih.gov/42281190/

For pesticide analysis, a robotic miniaturized & automated analysis platform
Miniaturized and automated analysis of pesticides in Cannabis sativa L. flowering tops by means of a robotic platform coupled to liquid chromatography-tandem mass spectrometry
https://www.sciencedirect.com/science/article/pii/S0039914026008106

For cannabis grown in West Africa, an analysis of the functional nutrients & antioxidant activities from different plant components
Functional Nutrients and Antioxidant Activity of Cannabis Sativa L
https://www.researchsquare.com/article/rs-9281008/v1

For the nitrogen requirements of irrigated hemp in a semi-arid climate, the genotypes affected the requirements, but the findings challenged the ‘low-input’ narrative associated with hemp
Genotype-specific nitrogen requirements overpower seeding density effects for irrigated fiber hemp in a high-elevation semi-arid climate
https://www.sciencedirect.com/science/article/pii/S0926669026010800

In cannabis under low nitrogen conditions, a genetic analysis of the nitrate transporter 1/peptide transporter family
Characterisation and expression profiles of the NPF gene family in Cannabis sativa L. under low nitrogen
https://link.springer.com/article/10.1186/s12870-026-08990-0

For distinguishing high-THCA versus low-THC cannabis, a genetic analysis of the synthesis enzymes involved
Integrative analysis of cannabinoid profiles, gene expression, and functional variants of THCAS and CBDAS distinguishes chemo-type I and III Cannabis sativa cultivars
https://link.springer.com/article/10.1007/s12892-026-00364-0

⚙️ Extracting, Analyzing & Formulating ⚙️

In forensic cannabis investigation, on using the DNA testing method of inter-simple sequence repeat (ISSR)-PCR analysis
Development of a similarity discrimination method for cannabis samples using Inter-Simple Sequence Repeat-PCR
https://link.springer.com/article/10.1007/s11419-026-00775-2

For separating cannabinoids in complex samples, on comparing different C18 columns via liquid chromatography
Evaluating Different C18 Columns for the LC Separation of Δ9-THC and Other Related Cannabinoids
https://link.springer.com/article/10.1007/s10337-026-04498-9

🏗️ Industrial Uses & Fiber 🏗️

For hemp fiber, a study of its structural evolution as the plant matures
Mechanical and structural evolution of hemp fibre along plant maturity
https://www.sciencedirect.com/science/article/pii/S0926669026008605

On the cosmetic potential of phenols from cannabis seeds, an analysis found inhibitory effects on enzymes associated with skin aging, inflammation & hyperpigmentation
Cosmetic potential of phenolic-rich extracts from Cannabis sativa L. seeds: Inhibition of enzymes involved in skin aging, inflammation and hyperpigmentation
https://www.sciencedirect.com/science/article/pii/S2468227626001572

For adhesives for textile laminates, on creating a composite of wood veneer & hemp fabric
Experimental Investigation of a Lignin-based Adhesive Layer for Biodegradable Composite Material Made With Wood Veneer and Hemp Fabric
https://www.imrpress.com/journal/FBE/18/2/10.31083/FBE44411

On creating nanocrystals for UV-shielding from cannabis stem fiber
Gamma-assisted engineering of cellulose nanocrystals from cannabis stem fiber for high-efficiency UV-shielding PLA/CNC–TiO2 transparent films
https://link.springer.com/article/10.1007/s00339-026-09817-3

For converting hemp stalks into nanocellulose, on tuning the temperature balance
Temperature-tuned hydrated DES/oxidation conversion of hemp stalks into carboxylated nanocellulose
https://www.sciencedirect.com/science/article/abs/pii/S0141813026030254

On turning hemp cultivated in sewage with biochar into cellulose
Sustainable valorization of hemp fibers: Influence of waste-amended cultivation on cellulose crystallinity and biopolymer synthesis
https://www.sciencedirect.com/science/article/abs/pii/S2589014X26003579

For hemp/epoxy composites, on the different treatments & conditions for improving performance
Synergistic Enhancement of Tensile, Flexural and Interlaminar Shear Performance of Hemp/Epoxy Composites Through Fibre Surface Treatment, Fabrication Temperature Optimization and CNT Incorporation
https://link.springer.com/article/10.1007/s12666-026-03857-2

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

For hemp in India, an analysis of its sustainability & usefulness for health & mindfulness
Synergizing Sustainable Hemp, Allied Health, and Mindfulness: Multidisciplinary Perspectives on Ethics and Law in India
https://journalofdaoiststudies.org/index.php/journal/article/view/387

🏥 Public Health & Bioassays 🏥

In US adults with psychological distress, they had higher odds of cannabis vaping
Association Between Psychological Distress and Cannabis Vaping Among U.S. Adults: A Cross-Sectional Analysis of the 2023 National Survey on Drug Use and Health (NSDUH) : A Nationally Representative Study
https://riviste.unimi.it/index.php/ebph/article/view/31277

For Queer cannabis use, the International Cannabis Policy Study found frequent & problematic patterns of cannabis use were most common among cisgender men, transgender men & transgender women
Gender identity and cannabis use in Canada and the United States: cross-sectional analysis of the International Cannabis Policy Study
https://link.springer.com/article/10.1186/s42238-026-00452-6

🧒 Adolescents & Young Adults 🧒

In Canadian students, the odds of beginning to use cannabis were highest among those with perceived easy access & close friends using cannabis
The role of perceived access to cannabis in the association between friends who use cannabis and adolescent initiation: A longitudinal analysis from the Canadian COMPASS study
https://pubmed.ncbi.nlm.nih.gov/42271491/

On the increased use of cannabis by US female adolescents, more frequent observation of parental smoking was associated with higher rates of alcohol, cannabis & e-cigarette use
Parental substance use modeling and monthly alcohol, cannabis, and e-cigarette use among female adolescents and young adults
https://psycnet.apa.org/record/2027-82789-001

In US adolescents from 2023 to 2024, cannabis use declined but delta-8 THC prevalence remained unchanged
Marijuana and Delta-8-THC Use Among U.S. Adolescents Between 2023 and 2024
https://www.sciencedirect.com/science/article/abs/pii/S0749379726001534

🧠 The Brain & Neurological Disorders 🧠

In people with severe epilepsies, this cohort study looked at the demographics of those who continued using CBD
Demographics and Clinical Factors Associated with Persistence on Cannabidiol in US Patients with Lennox-Gastaut Syndrome (LGS), Dravet Syndrome (DS), Tuberous Sclerosis Complex (TSC), or Other Refractory Epilepsies (P10-10.004)
https://www.neurology.org/doi/abs/10.1212/WNL.0000000000215667

In people taking CBD for severe seizures, there were no interactions with the drug cenobamate
Phase 1, Open-label, Fixed-sequence, Bidirectional, Pharmacokinetic (PK) Drug-drug Interaction (DDI) Study Between Cannabidiol (CBD) and Cenobamate (CNB) in Healthy Adult Participants (P11-10.002)
https://www.neurology.org/doi/abs/10.1212/WNL.0000000000215597

In people with treatment-resistant epilepsies, people who also had a genetic developmental & epileptic encephalopathy had similar response rates
Cannabidiol Efficacy in Patients with Lennox-Gastaut Syndrome with Developmental and Epileptic Encephalopathy-associated Genetic Variants: A Subgroup Analysis (P10-10.008)
https://www.neurology.org/doi/abs/10.1212/WNL.0000000000215584

In a mouse model of Parkinson’s disease, deleting the CB2 receptors in their brain lowered their involuntary movements from the treatment drug levodopa
Cannabinoid Receptor 2 Deletion in NeuroD6-positive Neurons Attenuates Levodopa-induced Dyskinesia in Parkinson’s Disease Mouse Model (P1-16.009)
https://www.neurology.org/doi/abs/10.1212/WNL.0000000000212819

In a mouse model of generalized tonic seizures, the anti-seizure effects of CBD & cenobamate synergized with each other
An Assessment of Acute Pharmacodynamic Drug-drug Interactions (PD-DDIs) Between Cannabidiol (CBD) and Cenobamate (CNB) in a Mouse Model of Generalized Tonic Seizures (P3-10.001)
https://www.neurology.org/doi/abs/10.1212/WNL.0000000000215410

For the α7 nicotinic receptor (an ion channel involved in brain function & inflammation), an analysis of how CBD caused inhibition via an allosteric site (not the main binding site) & how small changes to the receptor could convert CBD’s actions to strong positive allosteric effects
A cannabidiol-sensitive region involved in the allosteric modulation of the α7 nicotinic receptor
https://www.pnas.org/doi/abs/10.1073/pnas.2535398123

In a tissue model of neuroinflammation, the CB2 receptor interacted with the purinergic P2X7 receptor in the microglia (guardian immune cells of the brain) for anti-inflammatory effects
Unveiling the molecular crosstalk between the purinergic P2X7 receptor and cannabinoid subtype 2 receptor in human microglial HMC3 cells: New insights for multitarget therapies in neuroinflammation
https://www.sciencedirect.com/science/article/pii/S0753332226006827

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

For people using cannabis to sleep, it was more effective in those with good sleep hygiene
Daily-level associations between sleep hygiene, cannabis use, and sleep health outcomes
https://pmc.ncbi.nlm.nih.gov/articles/PMC13262785/

In a rat model of cocaine & alcohol use, the females had more CB1 receptors & less GABA (the brain’s most common inhibitory neurotransmitter) in their prefrontal cortex & hippocampus (memory center) while males had less glutamate (the brain’s most common excitatory neurotransmitter) in their hippocampus
Sex differences in hippocampal and prefrontal gene expression of endocannabinoid, glutamatergic and GABAergic systems and amino acids profile underlie cocaine plus ethanol seeking incubation
https://www.sciencedirect.com/science/article/pii/S0028390826002510

🧬 Reproduction & Hormones 🧬

In US pregnant women, cannabis surpassed tobacco use in 2022
Cannabis surpasses tobacco among pregnant women: national trends and predictors of use in the U.S., 2015–2023
https://www.sciencedirect.com/science/article/abs/pii/S0306460326001504

In people lactating after birth, the cessation of cannabis led to THC levels in their breast milk declining to undetectable within the first week, while the urinary metabolites were detected longer
Breast milk Δ9-tetrahydrocannabinol in cannabis users during the postpartum period: correlation between breast milk, maternal urine and saliva samples during early lactation
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1816611/full

🦴 Pain, Musculoskeletal & Surgeries 🦴

In an Illinois physician program for alternatives to opioids, a survey found they desired more education & expressed concerns about dispensary staff acting as proxy clinicians
“We need to get educated”: lessons from physicians certifying cannabis as an alternative to opioids in the Illinois Opioid Alternative Patient Program
https://www.tandfonline.com/doi/abs/10.1080/03007995.2026.2662699

For painkilling, a review of targeting the endocannabinoid, opioid & TRPV1 systems
TRPV1, Endocannabinoid, and Opioid Systems in Analgesia: Molecular Mechanisms and Drug Development Strategies
https://cdnsciencepub.com/doi/abs/10.1139/cjpp-2025-0328

For pain, on using THC to target the sodium channels for suppressing activation of the nociceptors (pain receptors)
Phyto-cannabinoids Inhibits Peripheral Nociceptors by Targeting Sodium Channels
https://icamh.org.il/wp-content/uploads/2026/05/Maatuf-Yossef.pdf

🍽️ The Guts, Nutrition & the Microbiome 🍽️

For older people with poor appetite, a dose of Sativex (a 1:1 THC:CBD pharmaceutical spray) did not alter appetite or the levels of ghrelin & GLP-1
Associations Between Sativex® Versus Placebo and Glucagon-like Peptide-1, Total Ghrelin, and Subjective Appetite in Older Adults with Poor Appetite: A Protocolized Secondary Analysis of a Double-Blinded, Randomized, Placebo-Controlled Crossover Trial
https://www.preprints.org/frontend/manuscript/4ca146443c226dc2092e3b47faf924e2/download_pub

In people with severe obesity who had a gastrectomy (surgical weight-loss that removes much of the stomach), “post-surgery circulating levels of EPEA and DHEA reduced, whereas levels of 2-AG, 2-LG, 2-DPG and 2-DHG increased”, with these levels being more closely intercorrelated after the surgery
Longitudinal changes in endocannabinoidome and dietary lipid profile in severe obesity: impact of sleeve gastrectomy
https://link.springer.com/article/10.1186/s12944-026-02988-1

💨 The Lungs 💨

On the lung response to inhaled cannabis in a mouse model, this ambitious thesis project focused on the aryl hydrocarbon receptor as key for coordinating the pulmonary response
The Aryl Hydrocarbon Receptor Equips the Lungs to Respond to Inhaled Cannabis Products
https://mcgill.scholaris.ca/items/3d1c4be0-179b-4428-8583-d0d5ce622352

💧 The Genitourinary System 💧

For the temporarily worsened urinary symptoms after a prostate biopsy, a combination of serenoa repens–lycopene–selenium & epilobium–palmitoylethanolamide–calendula reduced the odds of urinary problems
Serenoa Repens–Lycopene–Selenium and Epilobium–Palmitoylethanolamide–Calendula after transperineal prostate biopsy: a tertiary single center experience
https://link.springer.com/article/10.1007/s00345-026-06528-5

🎗️ Cancer & Chemotherapy 🎗️

In the adherence to medical cannabis use by people with cancer, two-thirds remained adherent at 6 months, with discontinuations attributed to perceived ineffectiveness & adverse events
Medical cannabis treatment non-adherence among oncology patients: A prospective cohort analysis in Israel
https://www.sciencedirect.com/science/article/pii/S1462388926001523

In lung cancer cells, CBG & CBC triggered cell death, autophagy (cellular recycling) & apoptosis (programmed cellular suicide) via the mitochondria (powerhouse of the cell)
Cannabigerol and Cannabichromene Induce Lung Cancer Cell Death and Apoptosis—Contribution of PPARα to Cannabigerol Effects
https://www.mdpi.com/2076-3921/15/6/754

In melanoma cells, CBD caused apoptosis (programmed cellular suicide) while preserving the integrity of the T cells via EIF2, ICAM1 & ITGB1
Cannabidiol Activates Integrated Stress Response Signaling and Immune Trafficking Programs in an A375 Melanoma–Jurkat T Cell Coculture Model: A Multi-Omics Analysis
https://pubs.acs.org/doi/full/10.1021/acsomega.6c01965

💊 Synthetic Cannabinoids & Hemp-Derived Cannabinoids 💊

For analyzing synthetic cannabinoids with high-resolution mass spectrometry, on using online databases for fragmentation analysis & better detection
Comprehensive profiling of synthetic cannabinoids fragment ions using UPLC-HRMS in conjunction with online databases
https://www.sciencedirect.com/science/article/abs/pii/S1570023226002758

Thanks.
- lex

PS: For traditional folk tunes for your kids (& you), here’s Jerry Garcia & David Grisman’s ‘Not For Kids Only’ (1993). Inspired by the 1959 album ‘Old Timey Songs for Children’ by the New Lost City Ramblers (which me, the wife & kids are currently loving), the 2 famed musicians Grisman (mandolin) & Garcia (guitar) desired to make an album for kids as an organic “answer to Barney [the saccharine TV show character]”. They tracked down the lyrics for traditional tunes that had gained popularity during the early 1960s folk revival & they recorded them in a series of intimate acoustic sessions at Grisman’s home studio. And they weren’t all happy songs either. Garcia famously advocated for giving children material with an edge: “Kids like weird shit in there, they like crazy stuff lurking around, things with teeth, crazy people. They’re realistic. They know the world is full of weird stuff and kids sort of prefer weird stuff, they rejoice in it. It’s no big thing, but it’s nice to be able to throw some music back in there that’s originally from that world; bring some of the weirdness back, take a chance a little. I mean it’s sort of trusting the kids that they can handle something more than terminal niceness.”

CBD for severe autism, cannabis for missing less work & harms for lungs & testicles

Lex Pelger WhiteWhaleCreations — Mon, 29 Jun 2026 13:56:23 GMT

Cannabinoids & The People,
or; Drugs & Drug Wars

🌟 This week 🌟

(#hashtags for jumping to articles by searching for them with your browser)

In kids with severe autism, the benefits of CBD sustained over a 2-year follow-up
Diary entries on cannabis anxiety
Medical cannabis laws linked to less workplace absenteeism
Harms: worse lung health in cannabis users (#lunghealth) & worse testicular dysfunction (#sperm)
Preclinical: CBD for fentanyl use disorder, Parkinson’s, neuropathic pain & Angelman syndrome
Ketamine for methamphetamine use disorder + MDMA for social anxiety + ayahuasca for advanced Alzheimer’s
For 5-MeO-DMT, the myth of traditional Indigenous use is a case of “fabricated ancestrality”
Harm reduction: Vancouver’s safer supply program for opioids caused many benefits (#safersupply)
War on Drugs: another (inhumane illegal) boat strike + DEA allowed huge shipments of fentanyl to cross the border

[numbers for C&P#192: 7.4k words, ~20 minutes reading time, 133 papers]

📌 Editor’s note 📌:
We’re back after a week off. And also, this is your official notice that this summer, this newsletter may not show up every Monday. I’ve got little kids & I live in Europe. We’ll be at the lake a lot, I’ll be minding them a lot & sometimes this newsletter will be the thing that has to give.

I also suspect that you all won’t mind that much. I doubt many of you are here for cutting-edge news updates. My place in the community seems to be diving deep through all the science & finding pearls for you that might otherwise get missed. So every week, the finishing off of this newsletter & the reformatting it for the various platforms takes about half a day. That’s time that I could be using for processing more science instead. So I’ll focus on making sure I stay on top of all the science & if a newsletter doesn’t show up once in a blue Monday, just picture me by the lake with a 5-year-old in my lap watching the boats go by …⛵...🏊…☀️.

Hello everyone,
Welcome to the 192^ndedition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news + the War on Drugs, harm reduction & other psychoactives. Support this work with a paid subscription or by buying me a coffee. If you purchase one of my canna-graphic novels based on Moby Dick, proceeds go to Americans for Safe Access to support medical cannabis patients.
For producing cannabinoid content, work with my company White Whale Creations: writing, science archives, social media, newsletters & podcasts.
As always, ask me anything!

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(nothing new. Been playing with the kids at the pool instead…)

And as always, at the bottom is the album of the week: the scintillating soul jazz of Young-Holt Unlimited

💖 Ways to support this work 💖

- Venmo: @Lex-Pelger

- PayPal: donate here

📣 A request to spread the word 📣

This newsletter only spreads by word of mouth, so please share to friends & colleagues.

🍃 BEST OF CANNABINOID SCIENCE 🍃

(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)

On InMed Pharmaceuticals, a Canadian drug company with a pipeline that includes a topical CBN cream for epidermolysis bullosa (a painful disease of skin blistering), a drug that activates the CB1 & CB2 receptors for macular degeneration & an Alzheimer’s drug that activates the CB1 & CB2 receptors
https://cannabinoidpipelineinsights.substack.com/p/inmed-pharmaceuticals-a-cannabinoid
And IGC Pharma who has an Alzheimer’s drug that combines a low dose of THC with melatonin
https://cannabinoidpipelineinsights.substack.com/p/another-cannabinoid-r-and-d-product
I’ve been enjoying this new newsletter ‘Cannabinoid Pipeline Insights’ that shares breakdowns of what’s going on in pharmaceutical cannabinoids. I’d recommend giving them a follow.

⚕️ Clinical ⚕️

In children with autism & severe treatment-resistant behavioral symptoms, a long-term follow-up of CBD found that the initial improvements were maintained or further improved upon, particularly in irritability, social withdrawal & hyperactivity, with a 40% reduction in medication usage.
Long-term follow-up of children with autism spectrum disorder and severe treatment-resistant behavioral symptoms treated with purified cannabidiol
https://pubmed.ncbi.nlm.nih.gov/42248366/

In a diary study of people starting to use cannabis for anxiety, this excellent collection of quotes found improvements in sleep, emotional regulation, relationships, motivation, daily functioning & overall well-being.
Beyond symptom change: a qualitative descriptive study of reported quality of life experiences among adults prescribed medicinal cannabis for anxiety disorders
https://link.springer.com/article/10.1007/s11096-026-02176-2

In people with PTSD, the use of medical cannabis was linked to a ~35% lower probability of urgent care or emergency department visits.
Impact of Medical Cannabis Treatment on Healthcare Utilization Among PTSD Patients: A Retrospective Cohort Study
https://www.mdpi.com/2673-5318/7/3/128

For medical cannabis patients in states with different cannabis laws, those in restricted states described concealment & legal risks while those in medical-only states encountered bureaucratic barriers & mixed provider support while those in fully legal states expressed autonomy but faced social misrecognition, with all patients reporting stigma, inconsistent clinical guidance & a need to self-manage treatment.
Beyond access: A comparative phenomenological study of medical cannabis patients in three legal contexts
https://www.sciencedirect.com/science/article/pii/S259029112600642X

For US cannabis laws & health-related workplace absenteeism, medical cannabis decriminalization reduced the likelihood of health-related work absences by ~7%, with no significant effect from adult-use laws.
Cannabis laws and health-related workplace absenteeism in the United States
https://www.tandfonline.com/doi/full/10.1080/15555240.2026.2680016

In a gendered analysis of US cannabis consumption since 2002, females have been converging with males in terms of greater consumption & dependence.
Gender convergence of cannabis use, dependence, and risk in the U.S.
https://www.sciencedirect.com/science/article/pii/S0049089X26000803

On screening for prenatal cannabis, a survey of nurses found one-third of states reported universal maternal toxicology testing even though this contradicts clinical guidelines.
An Exploratory Qualitative Study of Screening, Testing, and Reporting Prenatal Cannabis Use by Recreational Legalization Status
https://onlinelibrary.wiley.com/doi/abs/10.1111/birt.70083

For cancer pain & opioid usage, a meta-analysis of 15 studies found no significant effects from cannabinoids in placebo-controlled studies, but modest reductions in observational studies.
Cannabinoids and opioid consumption in cancer pain: a systematic review and meta-analysis
https://link.springer.com/article/10.1007/s00520-026-10856-y

For developing therapeutic reference ranges of the blood concentration levels of cannabinoids & their clinical effects, an analysis of 23 articles produced helpful therapeutic data.
Therapeutic Drug Monitoring of Cannabinoids: Therapeutic Reference Ranges for Delta-9-tetrahydrocannabinol in Medical Cannabis, Nabiximols, Dronabinol and Nabilone
https://pubmed.ncbi.nlm.nih.gov/42269696/
“For vaporized/smoked medical cannabis, an orienting therapeutic reference range of 15-30 ng/mL delta-9-tetrahydrocannabinol was identified for pain reduction in diabetic peripheral neuropathy, while concentrations of <20 ng/mL delta-9-tetrahydrocannabinol were significantly correlated with intraocular pressure reduction and 7.5-10 ng/mL with improvement of tic symptoms. Half-maximum effective concentrations of 7-29 ng/mL delta-9-tetrahydrocannabinol were reported for “high” effects. For nabiximols, a preliminary therapeutic reference range of 1-10 ng/mL delta-9-tetrahydrocannabinol was determined for treating neuropathic pain and spasticity in adults with multiple sclerosis. For chemotherapy-induced nausea and vomiting, a preliminary therapeutic reference range of 1-5 ng/mL for nabilone and 5-15 ng/mL delta-9-tetrahydrocannabinol for dronabinol was assessed. In conclusion, relatively low concentrations may be sufficient to achieve therapeutic effects across all substances studied, with medical cannabis demonstrating these effects at lower concentrations than typically observed in recreational use.”

📑 Reviews 📑

For muscle health & CBD, a review of the mechanisms of benefits for various pathologies.
Endocannabinoid system and skeletal muscle health: insights from cannabidiol
https://doi.org/10.1016/j.molmet.2026.102396

In dogs with epilepsy, a review of CBD found that it reduced the frequency & intensity of their seizures, especially in cases resistant to conventional anticonvulsants.
O USO DE CANABIDIOL NO TRATAMENTO DA EPILEPSIA IDIOPÁTICA CANINA: REVISÃO DE LITERATURA
https://openurl.ebsco.com/EPDB%3Agcd%3A1%3A39979697/detailv2?sid=ebsco%3Aplink%3Acrawler-gcd&id=ebsco%3Agcd%3A194352632&crl=c&jrnl=1981223X&link_origin=openurl.ebsco.com/openurl

For cannabis nursing, a new book on many aspects.
Comprehensive Nursing Approaches to Cannabis Nursing
https://www.igi-global.com/book/comprehensive-approaches-cannabis-nursing/389718

For the therapeutic use of cannabis, a new book on medical uses, metabolites, toxicity & regulations.
Cannabis: Therapeutic Potential, Secondary Metabolites, Toxicity, and Regulations
https://www.routledge.com/Cannabis-Therapeutic-Potential-Secondary-Metabolites-Toxicity-and-Regulations/Rai-Feitosa/p/book/9781003668190

A book on cannabis nursing.
Clinical Integration and Specialty Practice in Cannabis Nursing
https://www.igi-global.com/book/clinical-integration-specialty-practice-cannabis/410565

⚠️ Harms ⚠️

For testicular dysfunction & cannabis use, a meta-analysis of 18 studies found cannabis users had lower normal sperm morphology & higher levels of SHBG (sex hormone binding globulin) but no differences in sperm concentration, ejaculation volume, total sperm count, progressive motility or levels of testosterone or luteinizing hormone (#sperm).
Exploring the Association Between Cannabis Use and Testicular Dysfunction: A Systematic Review and Meta-Analysis
https://academic.oup.com/jsm/article/23/Supplement_4/qdag118.697/8702403

In the lung health of cannabis users, with or without the use of tobacco, one-third had at least 2 chronic respiratory symptoms & two-thirds had an abnormality in at least one lung-function test (#lunghealth).
Respiratory health and quality of life in chronic cannabis users: An exploratory study
https://pubmed.ncbi.nlm.nih.gov/42247890/

In US people with chronic medical conditions, they had lower rates of cannabis use disorder, except in those with respiratory diseases, with the greatest risk factors being past-year depression & the use of other substances.
Cannabis use and cannabis use disorder in adults with chronic medical conditions in the United States
https://www.sciencedirect.com/science/article/pii/S030646032600170X

For managing health emergencies related to cannabis & synthetic cannabinoids, a review of treatment options [Portuguese].
Manejo de emergências relacionadas à cannabis, seus derivados e canabinóides sintéticos: uma atualização
https://revistardp.org.br/revista/article/view/1611

For cannabis & mental health, public health data since 2016 found increased levels of cannabis users with self-reported poor mental health, with rates higher in women, young adults & Hispanics.
Trends and disparities in self-reported past-month poor mental health among individuals using cannabis in the U.S., 2016-2023
https://link.springer.com/article/10.1007/s00127-026-03145-w

For suicidal ideation & cannabis use disorder (CUD), this thesis project found that adults with CUD had 57% higher odds of past-year suicidal ideation.
Trends in the association between cannabis use disorder and suicidal ideation in the United States, 2014–2023
https://escholarship.org/content/qt7880q6g4/qt7880q6g4.pdf
As always, the question is whether the use of cannabis was worsening people’s mental health or if that the people with the worst mental health were turning to cannabis the most.

In Canadian college students, a survey found that those both gambling & using cannabis had higher levels of depression, anxiety & stress than either the cannabis-only or gambling-only groups.
Examining the Co-occurrence of Cannabis-Gambling Behaviors and Mental Health Outcomes in Canadian College Students
https://oasis.library.unlv.edu/gaming_institute/2026/May27/51/

For the effects of CBD on female fertility & offspring, this thesis project found that the highest dose increased unfertilized eggs, reduced fetal weights in males only & changed gene transcription in the placentas of both genders.
Impact of preconception cannabidiol use in young female mice on fertility and placental development
https://umontreal.scholaris.ca/items/f55d6f27-d6ae-478e-88f9-cc1be1daf12e

In a mouse model of prenatal CBD or THC exposure, a machine-learning pipeline found that pups from both groups had reduced body weight & that the “CBD-exposed dams showed a heightened, weight-dependent probability of retrieving their lightest pups”.
A deep learning pipeline (MAS-PRT) reveals that prenatal CBD, but not THC, uniquely drives weight-dependent hyper-reactivity in maternal pup retrieval
https://assets-eu.researchsquare.com/files/rs-9514277/v1/7317aa06-0549-4a7c-9dbc-dbfaf3c2a394.pdf?c=1781090460

🐁 Preclinical 🐁

In a mouse model of Angelman syndrome (a rare genetic disorder of the nervous system with severe intellectual disability, insomnia & seizures), injections of CBD increased REM sleep, improved sleep homeostasis & reduced spontaneous seizures.
Cannabidiol corrects sleep deficits and reduces spontaneous seizures in Angelman syndrome model mice
https://www.nature.com/articles/s41386-026-02462-7

In a mouse model of fentanyl use disorder, the inhalation of CBD lessened addiction & regulated cellular stress & senescence.
Cannabidiol (CBD) and Fentanyl
https://www.sciencedirect.com/science/article/pii/S2772559626002518

In a tissue model of Parkinson’s disease, a CBD-rich oil caused neuroprotective effects by lessening accumulation of alpha-synuclein, preserving homeostasis of dopamine & modulating inflammasome signaling.
Cannabidiol Protects Against 1-Methyl-4-Phenylpyridinium and Manganese-Induced Neurotoxicity via Nod-Like Receptor Protein 3 Inflammasome Suppression
https://pmc.ncbi.nlm.nih.gov/articles/PMC13249025/

In a rat model of neuropathic pain, CBD-rich extract reduced cold sensitivity but did not improve heat sensitivity.
Oromucosal Administration of a Cannabidiol-Enriched Cannabis sp. Extract for 2 Weeks Moderately Reduces Cold Hyperalgesia in Rats With Neuropathic Pain
https://pubmed.ncbi.nlm.nih.gov/42248695/

In a mouse model of liver injury from paracetamol, both cannabis extract & the terpene beta-caryophyllene reduced liver toxicity & improved liver architecture, with the terpene being more effective. Liver/preclinical.
Hepatoprotective Effects of β-Caryophyllene and Full-Spectrum Cannabis Extract Against Paracetamol-Induced Liver Injury in Mice
https://ljmas.com/index.php/journal/article/view/303

In a mouse model of PTSD, THC & CBD promoted avoidant coping responses & atrophy of the astrocytes (the brain’s most common support cell) in the nucleus accumbens (a reward center & regulator of feeding, stress & motivation), but only in males.
Cannabinoid use generalizes stress responses: involvement of astrocyte plasticity and activation of matrix metalloproteinases in the nucleus accumbens core
https://www.nature.com/articles/s41380-026-03687-0

In a mouse model of a high-fat westernized diet, the combination of CBD & omega-3 fatty acids lessened anxiety & improved memory performance.
Omega-3 And Cannabidiol Attenuate Anxiety And Memory Impairment In High Fat Diet Fed Mice Via Astrocytosis And Upregulation Of Brain Enzymes
https://besps.journals.ekb.eg/article_507794_2d8ade5817a7d6bb1213f573b115536e.pdf

In a mouse model of atherosclerosis (hardened arteries), the endocannabinoid oleoylethanolamide (the endocannabinoid of satiation) accelerated plaque removal via the regulatory T cells & genetic transcription via the PPARα receptors.
Oleoylethanolamide Enhances Regulatory T Cell Function to Accelerate Plaque Regression in Atherosclerosis via PPARα Activation
https://www.jbc.org/article/S0021-9258(26)02108-3/fulltext

In a mouse model of liver disease due to type II diabetes, the terpene beta caryophyllene (which activates the CB2 receptor) reduced oxidative stress & liver inflammation, scarring & injury markers.
Cannabinoid 2 Receptor Activation Mitigates High-Fat Diet/Streptozotocin-Induced Nonalcoholic Fatty Liver Disease in Diabetic Mice by Modulation of Oxidative Stress, Inflammation, and Fibrosis
https://pubs.acs.org/doi/full/10.1021/acsptsci.5c00610

🆕 Novel Studies 🆕

(my grab bag section for stuff I haven’t quite seen before)

The drug AB-MDMSBA was identified as a synthetic cannabinoid & banned, but this analysis found it did not actually bind to the CB1 receptor.
AB-MDMSBA—Not a Synthetic Cannabinoid Receptor Agonist
https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/prp2.70278

In a mouse model of depression being treated by transcranial magnetic stimulation, the benefits are mediated by CB1 receptors in the brain’s prefrontal inhibitory circuits.
Cell-type-specific CB1R signaling modulates prefrontal synaptic responses to HF-rTMS in chronically stressed mice
https://www.sciencedirect.com/science/article/abs/pii/S0166432826003098

📰 US Headlines & Fav Articles 📰

In the US, the White House sent a letter to urge Congress to keep hemp-derived products legal
https://www.marijuanamoment.net/white-house-pushes-congress-to-ensure-fair-treatment-of-hemp-products-by-calling-off-broad-recriminalization-law-set-for-november/
And a major restaurant lobby told Congress to keep hemp THC drinks legal
https://www.marijuanamoment.net/major-restaurant-lobby-group-pushes-congress-to-keep-hemp-thc-drinks-legal-as-an-alternative-to-alcohol/
And a Republican Congresswoman is circulating draft legislation to keep them legal under federal law
https://www.marijuanamoment.net/gop-lawmaker-circulates-bill-to-keep-hemp-thc-drinks-federally-legal/
And a look at the Minnesota breweries & drink distributors that will be hurt
https://www.mprnews.org/story/2026/06/16/minnesota-breweries-could-be-wiped-out-by-upcoming-hemp-thc-ban

The US Census Bureau said that legal cannabis has generated almost $15B in taxes in the last 5 years
https://www.marijuanamoment.net/new-federal-report-tracks-nearly-15-billion-in-marijuana-revenue-collected-by-states-over-the-last-five-years/

The DEA began their on-site inspections at cannabis businesses that registered for the new cannabis rescheduling process
https://www.marijuanamoment.net/dea-begins-on-site-inspections-at-marijuana-businesses-that-applied-for-federal-protections-under-trumps-rescheduling-move/

The US Supreme Court upheld the gun rights of cannabis users when they unanimously sided with a man that was prosecuted for possessing a gun while also being a cannabis consumer
https://www.marijuanamoment.net/supreme-court-says-prosecution-of-marijuana-user-for-possessing-gun-violates-second-amendment/

The US National Institute of Standards and Technology (NIST) added dozens of cannabis components to its library of reference data for identification
https://www.marijuanamoment.net/federal-science-agency-adds-new-cannabis-compounds-to-its-library-of-chemical-fingerprints/

The US expands wastewater testing for psychoactives
https://www.nytimes.com/2026/06/21/health/drug-testing-wastwater-sewage.html
While I’ve always been leery of the utility of wastewater testing for drugs, this article makes a pretty decent public health case for allowing local communities to expand their harm reduction measures around drugs that are showing up in the wastewater, such as xylazine (a tranquilizer frequently used to cut drugs) & nitazenes (a potent class of opioids).

History Corner: the famous quote about Nixon & the War on Drugs as well as his surprising turn towards harm reduction & treatment options (a 4-part series by Isaac Campos in conversation with Emily Dufton, author of ‘Addiction, Inc.’)
https://isaaccampos.substack.com/p/guest-post-dan-baum-should-have-known

🌐 International News 🌐

In Ukraine, the first legal medical cannabis products have been dispensed
https://www.marijuanamoment.net/ukraines-first-legal-medical-cannabis-products-have-been-dispensed-to-military-veterans-and-a-woman-with-ms/

In Ireland (sometimes known as the sanest country), the Joint Committee on Drugs Use recommended decriminalizing all drugs for personal use
https://www.rte.ie/news/politics/2026/0624/1580028-drugs-committee/

In Canada, the main national cannabis lobbying group suspended its operations, citing the financial challenges of the industry & its ability to sustain a national association due to the illicit market
https://www.cp24.com/news/canada/2026/06/22/national-cannabis-organization-suspends-operations-citing-active-illegal-market/

CanAdelaar, the largest licensed cannabis grower of the Netherlands, plans to be taken over by Cronos, a Canadian cannabis company which is owned 41% by Altria (a US tobacco giant)
https://cannabislaw.report/dutch-news-a-us-tobacco-giant-is-behind-the-planned-take-over-of-the-netherlands-biggest-licensed-cannabis-grower/

In Ontario, the government ordered the cannabis producer SNDL to sell its network of dozens of cannabis stores because they greatly exceeded the limit of being allowed to have one “farmgate” retail location
https://www.theglobeandmail.com/business/article-sndl-cannabis-producer-ontario-store-network/

In Himachal Pradesh, India, their Cabinet allowed for hemp & medical cannabis cultivation
https://www.aninews.in/news/national/general-news/himachal-cabinet-approves-regulated-cannabis-farming-farmers-to-benefit-from-high-value-crop-jagat-singh-negi20260620225532/

In Luxembourg after partial legalization, an interdisciplinary analysis found a limited overall impact in the first year, with the main effect being an increase in cannabis-related DUI cases.
Impact of partial cannabis legalisation in Luxembourg: An interdisciplinary perspective
https://www.sciencedirect.com/science/article/pii/S2772724626000491

⚖️ Business, Laws & Education ⚖️

A new US economic report found the first declines for legal cannabis revenue last year amidst price compression & oversupply as well as a 2.7% drop in cannabis-sector jobs
https://www.marijuanamoment.net/legal-marijuana-revenue-declined-for-the-first-time-in-2025-but-rescheduling-could-reverse-the-trend-industry-analysis-finds/

In New York’s social equity cannabis fund, a law thesis analysis found the failures to stem not from poor intentions but a structural failure to shift power.
WITH ALL THE STRINGS ATTACHED: ANALYZING PARTICIPATION OF DISEMPOWERED GROUPS IN STRUCTURING NEW YORK’S SOCIAL EQUITY CANNABIS INVESTMENT FUND
https://brooklynworks.brooklaw.edu/cgi/viewcontent.cgi?article=1694&context=jlp

For Ohio’s successful 2023 adult-use cannabis legalization, there was a positive relationship between a county’s medical dispensaries & its support for legalization, while a county’s overdose rate increases also led to increased support but this fell after a certain threshold.
Evaluating Ballot Initiative Results for Adult-Use Marijuana in Ohio: Understanding County-Level Support
https://onlinelibrary.wiley.com/doi/pdf/10.1111/polp.70144

For cannabis packaging & teen perceptions, a survey found that they identified colorful fonts, cartoonish imagery & product photos resembling candy or snack food packaging as appealing to people under 21.
Not just a label: Teens’ perceptions of what elements of cannabis product packaging appeal to underage individuals
https://www.sciencedirect.com/science/article/pii/S0955395926002070

For US cannabis warnings, a content analysis found that 93% of state cannabis programs required warnings, only half of warnings mention specific health risks, few programs required front-of-package warnings & warnings tended to be lengthy.
Characteristics of cannabis warnings in the United States: A content analysis
https://www.sciencedirect.com/science/article/pii/S2211335526001610

For product labeling in New York, a survey found participants had low recognition of the required symbols & mixed results on the impact of COAs.
Cannabis Consumers’ Understanding of New York State’s Required Cannabis Product Labeling
https://www.mdpi.com/2813-1851/5/2/17

For Canadian cannabis retail stores, an analysis of their violations of cannabis laws such as inducements to purchase, endorsements & testimonials, lifestyle promotion, youth-appealing content & health or cosmetic benefit claims.
Online promotional practices and apparent violations from licensed cannabis retail stores in Canada
https://www.sciencedirect.com/science/article/pii/S0955395926002021

For cannabis, a review from India with a focus on patents.
Cannabis sativa: A Review on Recent Patents and Advancements for Human Health
https://www.benthamdirect.com/content/journals/cbc/10.2174/0115734072335013250212101757

🚗 Driving 🚗

For cannabis-impaired driving, on developing a framework for integrating data from across US states.
A multi-state methodological framework for behavioral surveillance of cannabis-impaired driving
https://www.tandfonline.com/doi/pdf/10.1080/15389588.2026.2678490

🚓 The War on Drugs 🚓

Another Trump boat strike in the eastern Pacific killed 3
https://www.aljazeera.com/news/2026/6/19/us-kills-3-in-strike-on-alleged-drug-smuggling-boat-in-eastern-pacific

Along the US border, 9000 troops have been deployed for a year at the cost of tens of millions of dollars per week, with the patrols simply pushing the cartels into the more remote regions
https://www.nytimes.com/2026/06/20/us/politics/troops-border-mexico.html

In New Mexico, the DEA allowed shipments of hundreds of thousands of fentanyl pills to reach the streets so that they could bring bigger criminal cases against the traffickers
https://apnews.com/article/dea-fentanyl-unseized-drugs-new-mexico-8f5b546e668e5007c64078da74b90903

In Venezuela, the Tren de Aragua leader “Niño Guerrero” killed in a joint US/Venezuelan operation
https://insightcrime.org/news/tren-de-aragua-leader-nino-guerrero-killed-in-venezuela-says-trump/

In Vietnam, over 400 arrested in the largest-ever drug trafficking crackdown
https://e.vnexpress.net/news/news/crime/over-400-arrested-in-vietnam-s-largest-ever-drug-trafficking-crackdown-5084171.html

In the Philippines, an ex-narcotics policeman arrested in the drug-war killing of a South Korean businessman
https://www.straitstimes.com/asia/se-asia/philippine-ex-policeman-arrested-in-notorious-drug-war-killing

In Bangkok, an alleged Nigerian drug kingpin arrested after trying to ram his way through a police blockade
https://www.bangkokpost.com/thailand/general/3268863/allegednigerian-drug-kingpin-arrested-in-bangkok-after-dramatic-standoff

For general cargo vessels, they have been increasingly drawn into the drug trade
https://cannabislaw.report/general-cargo-vessels-increasingly-drawn-into-drug-trade/

On the cannabis smuggling network between Nepal & the northern Indian state of Bihar
https://english.nepalnews.com/s/crime-news/the-cannabis-corridor-inside-the-nepal-bihar-marijuana-smuggling-network/

In Brazil, an influencer/criminal lawyer known as “Advogata” is on the run after charges of masterminding a criminal drug trafficking organization
https://cannabislaw.report/brazil-glam-influencer-lawyer-on-the-run-after-drug-trafficking-kingpin-accusations/

In Baltimore, 5+ tons of cannabis bound for Europe seized
https://cannabislaw.report/over-10000-pounds-of-cannabis-bound-for-europe-seized-in-baltimore/

In the Strait of Gibraltar, 4.8 tons of hashish seized in a Moroccan/Spanish joint operation
https://cannabislaw.report/morocco-spain-seize-nearly-4-8-tons-of-hashish-in-joint-strait-of-gibraltar-operation/

In Australia, the largest ever cocaine bust with 2.7 tons seized from an underground bunker system
https://www.bbc.com/news/articles/c14ygjzr8j7o

On the Peace Bridge between Canada & the US, the border patrol seized $4M worth of cannabis disguised as chocolate
https://cannabislaw.report/cbp-seizes-4-million-shipment-of-marijuana-on-peace-bridge/

In Bulgaria, 6 men arrested for a smuggling operation of 400 kg of cannabis
https://cannabislaw.report/six-men-and-400-kg-of-marijuana-were-detained-during-a-special-operation-at-the-bulgarian-border-checkpoint/

In Pakistan, a police constable & a veterinarian were arrested with 300+ kilograms of opium & hashish
https://cannabislaw.report/pakistan-police-constable-and-a-veterinarian-arrested-near-kasur-in-anti-narcotics-operation-314-7kg-of-opium-and-hashish-seized/

In Portugal, 3 arrested in a boat smuggling operation with 56 bales of hashish
https://cannabislaw.report/portugal-three-arrested-after-56-bales-of-hashish-seized-in-aljezur/

In Malaysia, a man got 7 years & 10 strokes for possessing 300+ kg of cannabis
https://cannabislaw.report/malaysia-man-jailed-7-years-10-strokes-for-cannabis-possession/

In Wisconsin, a truck with cheese powder was busted for smuggling 60 kg of cocaine
https://cannabislaw.report/truck-hauling-cheese-powder-from-wisconsin-busted-for-cocaine-at-blue-water-bridge/

In Kuwait, the bust of an air shipment from Britain yielded 86 kg of drugs
https://cannabislaw.report/kuwait-foils-86kg-drug-smuggling-attempt-in-air-shipment-from-britain/

At a Sri Lankan airport, someone was arrested with hashish worth Rs. 377 million (~$1.1M)
https://cannabislaw.report/a-foreign-national-has-been-arrested-by-sri-lanka-customs-officers-at-bandaranaike-international-airport-bia-katunayake-after-being-found-in-possession-of-a-large-stock-of-hashish/

In Bali, 7.8 kg of hashish seized after a high-speed car chase
https://cannabislaw.report/russian-nationals-carrying-7-8kg-hashish-arrested-in-bali-after-high-speed-car-chase/
https://cannabislaw.report/bali-shots-fired-as-indonesian-authorities-arrest-three-russian-hash-smugglers/

In Ukraine, an organizer of drug parties had 2.5 kg of psychoactives “for every taste”
https://cannabislaw.report/life-during-wartime-kyiv-organizer-of-drug-parties-detained-2-5-kg-of-drugs-and-psychotropics-for-every-taste-found-at-his-home/

WoD Research

For youth cannabis offenses in Massachusetts, a racialized analysis on the effects of decriminalization & legalization.
Decriminalization, Legalization, and Racial Gaps in Police Response to Youth Marijuana Offenses
https://www.tandfonline.com/doi/abs/10.1080/15564886.2026.2680563

For darknet drug platforms, a thesis project on the push & pull between prohibition & platform capitalism.
The Other(Ed) World:Discourses Negotiating Probation, Identity, Trust and Motivation in a Darknet Drug Market Platform Community
https://lup.lub.lu.se/luur/download?func=downloadFile&recordOId=9227462&fileOId=9233995

In the Balkans, a dissertation on the smuggling of heroin, cocaine & migrants.
Cross-Border Smuggling in the Balkans: A Structure-Opportunity Theory Perspective, 2026
https://journals.sagepub.com/doi/abs/10.3233/NHSDP260027

🛡️ Harm Reduction News 🛡️

‘Ottawa’s last supervised consumption sites close amid fears of overdose risks’
https://capitalcurrent.ca/ottawas-last-supervised-consumption-sites-close-amid-fears-of-overdose-risks/

At New York’s overdose prevention center OnPoint, since their launch, they intervened in 2000+ overdoses with no fatalities
https://mailchi.mp/onpointnyc.org/june-2026-newsletter

The FDA approved the 3^rd over-the-counter naloxone product: Rextovy, a 4 mg naloxone nasal spray
https://filtermag.org/fda-rextovy-over-the-counter-naloxone/

Harm Reduction Research

In Vancouver’s safer opioid supply program, participants reported reduced drug use, craving/withdrawal & overdose risk as well as safer drug use behavior & improved physical health, mental health, financial stability & social connections.
Participant perspectives on a safe supply program in Vancouver, Canada: impacts, satisfaction and improvement priorities
https://link.springer.com/article/10.1186/s12954-026-01481-3

For funding administrators of harm reduction programs, a survey found that social stigma against people who use drugs allowed for political entrepreneurialism including politicians scapegoating harm reduction services.
Funding Community Health Services for People Who Use Drugs in San Francisco: Determinants, challenges, and opportunities to improve implementation
https://www.sciencedirect.com/science/article/pii/S2666560326000836

In Vancouver, sex workers who use drugs, the majority owned take-home naloxone, though a barrier was recent homelessness.
Take-home naloxone (THN) ownership among a community-based cohort of sex workers who use drugs in metro vancouver: longitudinal trends and structural determinants (2017-2024)
https://link.springer.com/article/10.1186/s12954-026-01483-1

For mobile addiction services, an analysis in Boston of their Community Care in Reach® model.
Multisite Mobile Addiction Services: Four-Year Outcomes
https://www.mdpi.com/1660-4601/23/6/756

In Australian community pharmacies, a survey found high engagement with harm reduction services.
Provision of harm reduction services in community pharmacies: Findings from an Australian national sample
https://pubmed.ncbi.nlm.nih.gov/42248708/

For fentanyl-related harm reduction, a review of 7 reviews found naloxone most consistently associated with reduced overdose mortality & improved bystander response as well as fentanyl test strips linked to behavior modifications.
Fentanyl-related harm reduction and structural determinants of overdose in the United States: An umbrella review with AMSTAR-2 Appraisal
https://www.researchgate.net/publication/405725999

For people who use crack, a review of safer smoking equipment programs found reduced pipe sharing, decreased injecting & improved engagement with health & social services.
Provision of safer smoking equipment to reduce health harms and enhance service engagement among people who use crack: a realist informed review
https://researchonline.ljmu.ac.uk/id/eprint/28750/1/Provision%20of%20safer%20smoking%20equipment%20to%20reduce%20health%20harms%20and%20enhance%20service%20engagement%20among%20people%20who%20use%20crack-%20a%20realist%20informed%20review.pdf

In India, a review of their harm reduction programs for people who inject drugs.
The harm reduction shift: A review of India’s NACP strategies for PWID
https://pmc.ncbi.nlm.nih.gov/articles/PMC13252326/

🍄 Psychoactives, Psychedelics & Plant Medicines 🍄

In Northern California, a spate of amanitas mushroom poisonings led to 4 deaths & 3 liver transplantations
https://www.cdc.gov/mmwr/volumes/75/wr/mm7520a2.htm

In Japan, on psychedelics in books & media.
From Exotic to Indigenous: Psychedelic Plants and Fungi in Countercultural Japanese Media
https://academic.oup.com/isle/advance-article/doi/10.1093/isle/isag028/8702686

Psychedelics & MDMA

For 5-MeO-DMT, its reputation as an ancient indigenous tradition as an example of “fabricated ancestrality”
Fabricated ancestrality: The Sonoran Desert toad, psychedelic globalization, and the ecological politics of 5-MeO-DMT
https://www.sciencedirect.com/science/article/pii/S2950484826000056

For MDMA in people with social anxiety disorder, a randomized trial found great improvement in anxiety scores.
MDMA-Assisted Therapy for Social Anxiety Disorder: A Randomized, Open-label, Wait-list Controlled Trial
https://www.researchgate.net/publication/406181781

For psychedelics & PTSD, a meta-analysis of 11 randomized controlled trials found moderate-to-large reductions in symptom severity, with ketamine effects being small & MDMA being more promising.
Psychedelic-Assisted Psychotherapy for the Treatment of PTSD: A Systematic Review and Meta-Analysis
https://www.mdpi.com/2813-1851/5/2/16

In a person with advanced Alzheimer’s disease, a case report of high-dose psilocybin leading to spontaneous autobiographical speech as well as improved ambulation, autonomous dressing, increased emotional responsiveness, sustained social interaction, potential memory retrieval, spontaneous conversation in engagement & the restoration of urinary incontinence
Transient multidomain functional improvement in advanced Alzheimer’s disease following high-dose psilocybin-containing mushroom administration: a case report
https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1813281/full?utm_source=substack&utm_medium=email

On trans people & psychedelics, a Reddit analysis of the themes of their experiences.
Altered states, authentic selves: Trans individual’s experiences with psychedelics and their implications for Psychedelic-Assisted Psychotherapy
https://www.tandfonline.com/doi/pdf/10.1080/26895269.2026.2681667
“Four themes were identified. The first acknowledged how psychedelic-induced altered states can lead to self-acceptance, gender euphoria, and gender realization. The second explored how psychological release during psychedelic trips can also facilitate a journey of self-acceptance. The third explored how these experiences can function as a catalyst for change. The last theme explored how psychedelic-induced altered states can simultaneously support and exasperate gender dysphoria.”

For psychedelics & ADHD, a review of 6 studies found insufficient evidence of efficacy.
The effects of psychedelics on attention deficit and hyperactivity disorder - a systematic review
https://pubmed.ncbi.nlm.nih.gov/42265057/

For psychedelics, a review of their structure-activity relationships.
Short- and Long-Acting Psychedelics: Structure–Activity Relationships, Pharmacology, and Implications for Neuropsychiatric Therapeutics
https://pubs.acs.org/doi/full/10.1021/acschemneuro.6c00202

Ketamine

For methamphetamine use disorder, ketamine-assisted psychotherapy facilitated a temporary psychological space for engagement with psychotherapy.
Navigating ‘K-Land’: A Qualitative Exploration of Participants’ Experiences of Study of Ketamine-Assisted Psychotherapy for Methamphetamine Use Disorder
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1873497/abstract

In Norwegian ketamine-assisted psychotherapy, interviews on the ethics of its use found the main themes to be access to care, informed consent & therapeutic integrity.
Psychedelic ethics in practice: The case of ketamine-assisted psychotherapy in Norway
https://www.akjournals.com/view/journals/2054/aop/article-10.1556-2054.2026.00486/article-10.1556-2054.2026.00486.xml

In ketamine for depression, a survey of providers on their therapeutic practices, modalities & treatment goals.
Ketamine-Assisted Psychotherapy for Depression: A Survey of Current Practices, Rationales, and Future
https://www.tandfonline.com/doi/pdf/10.1080/02791072.2026.2685515

In people with bipolar depression, compared to electroshock therapy, ketamine infusions caused similar benefits in only half of the patients.
Electroconvulsive Therapy and Ketamine Infusion in Patients with Bipolar I or II Depression: A Case Series
https://pubmed.ncbi.nlm.nih.gov/42267236/

In adolescents with acute behavioral disturbances, a review on the use of intramuscular ketamine.
PP39 Intramuscular ketamine for management of paediatric acute behavioural disturbance: a scoping review
https://emj.bmj.com/content/43/Suppl_2/A18

For acute pain in the emergency department, a review of intramuscular ketamine found it comparable to IV morphine.
Intranasal ketamine versus intravenous opioids for acute pain in the emergency department: A scoping review
https://www.sciencedirect.com/science/article/abs/pii/S0735675726002755

For combining nano-ketamine & sertraline (Zoloft) in a rat model of depression, together they caused rapid onset & sustained drug action with benefits for oxidative stress & inflammation.
Intranasal nanoformulations of ketamine and sertraline: Comparative insights into combined protective antidepressant effect
https://www.sciencedirect.com/science/article/abs/pii/S1773224726006076

Kratom

For a trauma patient, his use of the kratom alkaloid 7-OH may have contributed to a hypersensitivity to pain.
7-Hydroxymitragynine Induced Perioperative Hyperalgesia in 27-year-old Trauma Patient
https://scholarlycommons.hcahealthcare.com/cgi/viewcontent.cgi?article=1050&context=southatlantic2026

For kratom withdrawal in Malaysia, a survey of medical practitioners found opioid agonists commonly used for treatment.
The assessment and treatment of kratom dependence: findings from a physician survey in Malaysia
https://www.tandfonline.com/doi/full/10.1080/00952990.2026.2677090

For the metabolites of kratom, an analysis of how they move through humans.
Mitragynine and 7-hydroxymitragyine plasma pharmacokinetics in humans after single and 15 multiple oral kratom extract doses
https://academic.oup.com/jat/advance-article/doi/10.1093/jat/bkag042/8704792

Kava

On kava for anxiety disorders, a review of the clinical evidence & mechanisms of action.
Kava Kava in Anxiety Disorders: Current Evidence and Clinical Implications
https://apcz.umk.pl/JEHS/article/view/72694

Khat

In Madagascar, the cultivation of khat boosted local economic development & was more profitable than vegetable selling.
An assessment of the khat and vegetable trade in the local economic ecosystem: The case of northern Madagascar
https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0331722

🍃 The Plant & its Products 🍃

🌱 Growing 🌱

For hemp & flax production, a review of the impacts of global warming & their possibility for carbon sequestration & bio-based composites.
Projected impacts of global warming on the production and qualities of hemp and flax plants and fibres: Toward adaptation strategies
https://www.sciencedirect.com/science/article/pii/S0926669026009003

For growing hemp, an analysis of mulch management & chemical systems on yield.
Cover Crop Based Reduced Tillage Management of Floral Hemp
https://www.researchgate.net/publication/405803068

For hemp with drought stress, an analysis of seed priming with selenite & selenate on germination & early sprout growth.
Influence of selenite and selenate seed priming duration on the mitigation of drought stress in industrial hemp
https://www.croris.hr/crosbi/publikacija/prilog-skup/947082

For hemp exposed to forever chemicals, on using spectroscopy for detection & to analyze performance.
Short-wave infrared hyperspectral imaging coupled with ECOC-SVM classification enables discrimination of hemp plants treated with PFOA and PFOS
https://www.sciencedirect.com/science/article/pii/S2213343726023651

In cannabis research, a book chapter on the molecular markers.
Scope of Molecular Markers in Cannabis Research
https://www.taylorfrancis.com/chapters/edit/10.1201/9781003542681-13/scope-molecular-markers-cannabis-research-anna-zilov-arpan-modi

For cannabis flowering, a genetic analysis of the MADS-box transcription factors.
Genome-wide characterization of MADS-box genes reveals CsaSOC1 as a key regulator of flowering in Cannabis sativa L.
https://link.springer.com/article/10.1007/s00299-026-03871-0

⚙️ Analyzing & Formulating ⚙️

For delivering CBD, a review of the different systems.
Enhancing therapeutic efficacy of cannabidiol through the development of advanced delivery systems
https://eprints.ugd.edu.mk/38492/

For masking the taste of cannabinoids (CBD & CBG), on using oil-in-water emulsions.
Oil-in-water Emulsion as a Strategy for Taste Masking of Cannabinoid Extract
https://link.springer.com/article/10.1208/s12249-026-03472-w

For hemp protein extractions, comparing the alkaline & cold plasma methods.
Comparison of the physicochemical properties of hemp protein extracted using alkaline and cold plasma methods
https://www.sciencedirect.com/science/article/pii/S2772502226005421

For analyzing cannabinoid levels, on the effects of polysaccharides on retention.
Impact of chemical structure and substituents of polysaccharide-based chiral stationary phases on cannabinoids retention under normal phase conditions
https://pubmed.ncbi.nlm.nih.gov/42262577/

🏗️ Industrial Uses & Fiber 🏗️

For solar panels, on reinforcement & optimization with hemp-sisal/poly(lactic acid) (PLA) hybrid biocomposites.
Development of Biosilica-Reinforced Hemp-Sisal/PLA Hybrid Biocomposites for Lightweight Photovoltaic Panel Structures with Fossa Optimization-Based MPPT Performance Evaluation
https://www.researchgate.net/publication/405661505

On a compression ignition engine fueled with pine oil & hemp oil methyl ester.
Optimization of Combustion, Performance, and Emission Characteristics of a Reactivity Controlled Compression Ignition Engine Fueled with Hemp Oil Methyl Ester and Pine Oil Blends using Response Surface Methodology
https://www.jafmonline.net/article_2952_1b79b52d1bf6f71b2b1eb7ca08ed0776.pdf

On obtaining graphene oxide by the burning of waste hemp biomass.
Microwave-assisted pyrolysis of waste hemp biomass for the synthesis of graphene oxide–like material: A feedstock-process-structure-property relationship study
https://www.sciencedirect.com/science/article/pii/S0961953426007397

For automotive panels, on the impact resistance of a composite of carbon, kenaf & hemp.
Structure–Property Relationship of Carbon–Kenaf–Hemp-Reinforced Sandwich Composites for Impact-Resistant Automotive Panels
https://link.springer.com/article/10.1007/s11665-026-14188-0

On polymeric composites for automotive applications using hemp & coconut fiber epoxy reinforced with carbon black.
Mechanical and thermal performance of hemp and coconut fibers epoxy composites reinforced with carbon black for automotive applications
https://www.sciencedirect.com/science/article/pii/S2949822826008154

For epoxy composites in automotive interior applications, evaluating different ratios of hemp fiber & Indian mallow fiber.
Investigation of thermal, acoustical and wear properties for effective hybridization of Abutilon Indicum and hemp fiber in the epoxy-based composites
https://link.springer.com/article/10.1007/s13726-026-01688-y

For hemp/epoxy composite, on comparisons to flax-epoxy composites.
Comparative Mechanical Performance of Alkali-Treated Unidirectional Flax/Epoxy and Hemp/Epoxy Composite Manufactured via VARIM
https://www.mdpi.com/2413-4155/8/6/133

For hemp fiber-reinforced concrete, on using AI to predict its mechanical & durability properties.
Artificial Intelligence-Driven Prediction of Mechanical and Durability Properties of Hemp-Fiber-Reinforced Concrete
https://www.researchgate.net/publication/406425172_Artificial_Intelligence-Driven_Prediction_of_Mechanical_and_Durability_Properties_of_Hemp-Fiber-Reinforced_Concrete

For recycled concrete, hemp rope enhanced strength & strain with little loss due to temperature.
Temperature-resilient performance of hemp rope–Confined recycled aggregate concrete in axial compression
https://www.sciencedirect.com/science/article/pii/S2666682026000605

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

🏥 Public Health & Bioassays 🏥

In California after legalization, a public health survey found that doctor-recommended cannabis use fell by half but cannabis use held steady.
Doctor-Recommended Cannabis Use in the Era of Legalization: Trends from California (2019-2024)
https://journals.sagepub.com/doi/full/10.1177/25785125261452930

In a survey of Canadians before & after legalization, they had only modest differences in the knowledge of cannabis health effects, with the highest agreement on the risk of impaired driving & lowest agreement for schizophrenia risk, as well as significantly decreased awareness of harms related to pregnancy, breast-feeding, driving, schizophrenia & diabetes.
Knowledge about the health effects of cannabis before and after legalization of ‘recreational’ cannabis in Canada: findings from the International Cannabis Policy Study, 2018–2024
https://link.springer.com/article/10.1186/s42238-026-00428-6

For Canadians who use cannabis with other drugs, they had 3 classes of use.
Simultaneous use of cannabis with other drugs: Identifying latent classes in a sample of Canadians
https://pubmed.ncbi.nlm.nih.gov/42247742/
“We identified three latent classes: 1) low overall simultaneous use with occasional simultaneous use of cannabis with alcohol, 2) simultaneous use of cannabis with alcohol and hallucinogens, and 3) high overall simultaneous use (i.e., simultaneous use of cannabis with alcohol, hallucinogens, illicit stimulants, and prescription drugs).”

A Reddit analysis of cannabis use & cessation.
Understanding Cannabis Use and Cessation Through LLM-Based Analysis of Reddit Narratives
https://aisel.aisnet.org/cgi/viewcontent.cgi?article=1011&context=treos_ecis2026

For cannabis harm reduction in Queer youth, community engagement for identifying research priorities.
Community-informed priorities for cannabis harm reduction research among LGBTQIA+ youth: Insights from a World Café
https://pubmed.ncbi.nlm.nih.gov/42247745/

In human urine after taking Δ8-THCV, an analysis of the metabolites found.
Metabolite patterns in human urine after oral administration of highly purified Δ8-THCV
https://link.springer.com/article/10.1007/s11419-026-00772-5

In human blood & urine, a simplified method for quantifying CBD, THC & their metabolites.
An improved method for quantification of cannabidiol, Δ9-tetrahydrocannabinol, and their metabolites in human plasma and urine
https://www.sciencedirect.com/science/article/pii/S0731708526002670

For monitoring semi-synthetic cannabinoids in UK consumer products, on an LC-MS/MS method.
Development and validation of an LC–MS/MS method for monitoring semi-synthetic cannabinoids in UK consumer products: an evidence-based analytical, regulatory, and pharmacovigilance framework
https://www.sciencedirect.com/science/article/abs/pii/S0026265X26017935

🧒 Adolescents & Young Adults 🧒

In US young adults, cannabis use has increased rapidly in the last 25 years, with the rate of increase highest in females.
Secular Trends and Predictors of Frequent Cannabis Use From 2002-2019 in the United States
https://www.sciencedirect.com/science/article/abs/pii/S0025619626173492

For drugs at US universities, state cannabis legalization substantially reduced arrests & disciplinary incidents for drug law violations.
Impact of legalization of recreational marijuana on drug law violations: Evidence from US colleges and universities
https://www.sciencedirect.com/science/article/pii/S0165176526002752

In undergraduates with anxiety, they had a heightened risk for experiencing cannabis-related consequences.
Does social anxiety influence reporting of cannabis consequences? A differential item functioning analysis of the Brief Marijuana Consequences Questionnaire (B-MACQ)
https://www.sciencedirect.com/science/article/abs/pii/S0306460326001747

For young adults using cannabis, an app with interventions was associated with less cannabis use.
Mobile intervention for emerging adults with regular cannabis use: a micro-randomized trial
https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(26)00154-7/fulltext

🧠 The Brain & Neurological Disorders 🧠

In the mouse hippocampus (a memory center of the brain), CBD altered gene expression related to energy levels & modulated endocrine stress markers.
Selective hippocampal transcriptional adaptation to long-term cannabidiol exposure in mice
https://link.springer.com/article/10.1186/s12864-026-13028-8

In tissue & mouse models of ALS, inhibiting FAAH (the enzyme that degrades the endocannabinoid anandamide) lessened motor neuron degeneration “through the regulation of microglial environment, synapse plasticity, and neuronal development” as well as higher levels of endocannabinoids & N-acyl taurines.
Fatty acid amide hydrolase inhibition for treatment of amyotrophic lateral sclerosis
https://df6sxcketz7bb.cloudfront.net/manuscripts/198000/198842/jci.insight.198842.v1.pdf

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

In German problematic cannabis users, an analysis of their demographics.
Who is at risk? Core mental health symptoms and problematic cannabis use in Germany
https://link.springer.com/article/10.1186/s42238-026-00430-y

For protective behavioral strategies around cannabis use, the use of more protective strategies predicted subsequent reduction in use frequency but not quantity or consequences, while conversely, experiencing higher-than-usual negative consequences predicted subsequent increases in protective behavioral strategies use.
Bidirectional associations between protective behavioral strategies for cannabis use and cannabis outcomes: A cross-lagged longitudinal approach
https://www.sciencedirect.com/science/article/pii/S0306460326001668

For people who use cannabis, this cannabis-cue priming study (where they expose people to the look, smell & feel of cannabis) found that this caused them to experience cravings & also in the people who use it to enhance their attention, exposure caused faster task performance.
Cannabis cues, motives, and attention enhancement: A cannabis priming pilot study.
https://psycnet.apa.org/record/2027-79800-001

In a rat model of depression, the combination of CBD & temozolomide (an anticancer drug) caused antidepressant effects in males but not females.
Antidepressant-like effects of cannabidiol when combined with temozolomide in adult rats
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1873308/abstract

In a female rat model of adolescent social instability stress, blocking the CB1 receptor increased social interaction & social reward motivation.
Adolescent cannabinoid type 1 receptor (CB1R) blockade mitigates the effects of adolescent social instability stress (SS) on socially directed behaviour in female rats
https://www.sciencedirect.com/science/article/pii/S0306453026001976

🧬 Reproduction & Hormones 🧬

In people using cannabis during pregnancy, a survey of their demographics.
Cannabis Use Transitions During Early Pregnancy
https://publications.sciences.ucf.edu/cannabis/index.php/Cannabis/article/view/353

In pregnant ferrets in their 3rd trimester, a thesis project on the effects of THC (as well as alcohol) in the offspring.
Effects of Developmental Alcohol and Δ9-Tetrahydrocannabinol (THC) in Ferrets
https://www.proquest.com/openview/e18ac1fe7480ff51c4bd431e2f081d33/1

🦠 The Immune System & Microbial 🦠

In treatment-resistant autoimmune diseases, this case series of 70 patients found a regimen of melatonin, CBD & angiotensin 1-7 (a vasodilator) caused improvements to blood antibody levels & clinical symptoms.
Melatonin, angiotensin 1-7, and cannabidiol in refractory autoimmune disease: clinical case series
https://www.academia.edu/3071-4087/2/2/10.20935/AcadNeurosci8343

🦴 Pain, Musculoskeletal & Surgeries 🦴

In a mouse model of Duchenne muscular dystrophy, their gut microbiome had less of the bacteria that produce short-chain fatty acids & commendamide (a rather unknown endocannabinoid-like molecule) which demonstrated significant protective effects including for promoting antioxidant genes via the PPAR nuclear receptor.
Bacteroides-derived endocannabinoid-like commendamide attenuates skeletal muscle ferroptosis in vitro: implications for Duchenne muscular dystrophy
https://link.springer.com/article/10.1186/s12967-026-08407-4

In a mouse model of inflammatory pain, inhibiting the FAAH enzyme (which breaks down the endocannabinoid anandamide) reduced pain levels via opioid receptors & heme oxygenase-1 in the amygdala (an emotional processing center).
Fatty acid amide hydrolase (FAAH) inhibitor reduces persistent inflammatory pain in mice depending on mu- and delta-opioid receptors activity: Involvement of heme oxygenase-1
https://www.sciencedirect.com/science/article/pii/S0166432826003050

🍽️ The Guts, Nutrition & the Microbiome 🍽️

In people with pancreatitis leading to hyperuricemia (high levels of uric acid) & in a mouse model, the high uric acid levels exacerbated the pancreatitis via the retrograde endocannabinoid signaling of the CB1 receptor enhancing inflammatory cytokines from the macrophages.
Hyperuricemia aggravates acute pancreatitis through CNR1-mediated inflammatory signaling and gut-pancreas axis dysregulation: a multi-omics and clinical study
https://www.nature.com/articles/s41598-026-54458-4_reference.pdf

On 3D-printing plant protein composites using protein powders from hemp & Australian sweet lupin.
An investigation into the textural profile of cooked 3D-printed plant protein composite formulations using Australian sweet lupin (Lupinus angustifolius) and hemp (Cannabis sativa L.) protein powders
https://www.sciencedirect.com/science/article/pii/S2772502226005895

For THC as a probe into type 1 diabetes, a hypothesis paper on a shift of endocannabinoid tone toward CB2-associated regulatory signaling with changes to intestinal barrier dynamics, immune polarization & the blood-pancreas barrier.
Δ⁹-Tetrahydrocannabinol, a Cannabis sativa–Derived Natural Product, as a Probe of Endocannabinoid System Plasticity in Type 1 Diabetes: A Receptor-Level, Testable Hypothesis
https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2026.1812441/abstract

👀 The Eyes 👀

In a mouse model of retinal damage from early diabetes, activating their CB2 receptors decreased inflammatory cytokines & improved survival of photoreceptors.
1242-OR: Cannabinoid Receptor 2 Agonism Decreases Retinal Inflammation and Is Neuroprotective in Diabetic Retinopathy Models
https://diabetesjournals.org/diabetes/article/75/Supplement_1/1242-OR/167133

🖐️ The Skin & Topicals 🖐️

For hemp leaf extracts & skincare, an analysis of ethanol versus propylene glycol extraction for composition & bioactivity found propylene glycol to be better for cosmetic stability & formulation.
Comparative Study of Ethanolic and Propylene Glycol Extraction of Hemp Leaf Extracts: Phytochemical Analysis and Skincare Formulation Development
https://ejournals.swu.ac.th/index.php/sej/article/view/17324

🎗️ Cancer & Chemotherapy 🎗️

In a computer analysis of cancer cells, mutations were found in both their CB1 & CB2 receptors.
CNR1 and CNR2 Cannabinoid Receptor Mutations in Cancer Cells
https://www.mdpi.com/1467-3045/48/6/610
“In silico 3D structure of proteins reveals that these mutations cluster on the intracellular regions of CNR1 and CNR2, and certain residues may be able to destabilize the interaction with the G-alpha protein due to their close proximity. mRNA expression showed that CNR1 and CNR2 are within normal expression levels in most cancer types except kidney, where there is a tendency towards over-expression. Neither CNR1 nor CNR2 is a driver gene, and our analysis shows that mutations in cancer cells are deactivating (e.g., loss of function).”

🔬 Biochemical Discoveries & Research Tools 🔬

For the enzyme that produces CBC acid, an analysis of its binding & activity.
Improvement of cannabichromenic acid synthase activity and construction of recombinant yeast strain
https://link.springer.com/article/10.1007/s00203-026-04976-6

An analysis of the conversion of CBN into the phenanthrene CNP via light.
From Cannabinol (CBN) to Cannabiphenanthrene (CNP): A photochemical cascade reaction. A steady-state and time-resolved spectroscopic investigation
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6908683

On creating phenyl-carbamates for inhibiting the FAAH enzyme as well as blocking the TRPV1 channel.
Structure-guided discovery of phenyl-carbamates as novel dual TRPV1 antagonists/FAAH inhibitors
https://pubmed.ncbi.nlm.nih.gov/42242015/

For cannabinoid bromination (adding a bromine, a common technique for improved potency or breakdown resistance), a comparison of 3 different methods.
Bromination of Cannabinoids from Cannabis sativa L.: A Comparative Study Using an Enzymatic Catalysis Approach
https://pubs.acs.org/doi/full/10.1021/acs.orglett.6c01788

Thanks.
- lex

PS: For today’s scintillating soul jazz, ‘The Definitive Young-Holt Unlimited’. It all comes back to the drummer Isaac “Redd” Holt & the bassist Eldee Young meeting at the American Conservatory of Music in Chicago. They initially began in 1956 by forming a jazz trio named after their drummer Ramsey Lewis. But after a decade with him, they broke out to form their group the Young-Holt Trio with the pianist Hysear Don Walker, with their first Top 20 R&B hit being ‘Wack Wack’ (track #2 above). In 1968, Walker was replaced by Ken Chaney & the group changed their name to Young-Holt Unlimited, adding more funky rhythms to their repertoire. Their first smash hit was the instrumental “Soulful Strut” (track #3) & they recorded for the next 5 years before breaking up. Their influence continued into the hip-hop era with the band being sampled over 200 times. And I don’t know what it is that makes this album so delightful but between their covers of songs from the Doors & their delightful scat & patter, it’s been a delightful week having them play in the background this whole time.

Inhaled cannabis for back pain, THC & CBD for postsurgical pain + cannabis-associated violence

Lex Pelger WhiteWhaleCreations — Mon, 15 Jun 2026 10:44:28 GMT

Cannabinoids & The People,
or; Drugs & Drug Wars

🌟 This Week 🌟

(#hashtags for jumping to articles by searching for them with your browser)

For chronic lower back, crazy good data on inhaled cannabis
For total knee replacements, high levels of CBD & low levels of THC for postsurgical pain
On cannabis-associated violence (#Sikhs)
Even sitting in a smoke-filled car can make your hair test positive for THC (#passive)
Preclinical: cannabis for fatty liver + CBD for Alzheimer’s + CBG for obesity
War on Drugs: Trump’s first boat strike probably killed human-trafficking victims (#boatstrike) + Federal cannabis trafficking cases fell to another record low
Kratom trial just greenlit by FDA for opioid use disorder
Harm reduction: the underground “hit doctors” of Canada (#hitdoctors)

[numbers for C&P#191: ~4.3k words, ~12 minutes reading time, 82 papers]

📌 Editor’s notes 📌:
The newsletter will take a break next week because of travels.

Hello everyone,
Welcome to the 191^st edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news + the War on Drugs, harm reduction & other psychoactives. Support this work with a paid subscription or by buying me a coffee.

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🎥 Lex’s new work 🎤

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Canna-edu videos sponsored by the National Cannabis Study (join & get paid $100 to talk about your use of our favorite plant)
- nothing new this week. working on a big one on CBD & the EU’s declaration of it as a reproductive toxicant

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the Huainanzi & Perfected People

And as always, at the bottom is the album of the week: country-soul pioneer, Arthur Alexander

💖 Ways to support this work 💖

- Venmo: @Lex-Pelger

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📣 A request to spread the word 📣

This newsletter only spreads by word of mouth, so please share to friends & colleagues.

🍃 BEST OF CANNABINOID SCIENCE 🍃

(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)

⚕️ Clinical ⚕️

In people with chronic low back pain, 5 years of inhaled cannabis was associated with “large, sustained, and statistically robust improvements in pain, disability, and pain interference, accompanied by near-total displacement of opioids, NSAIDs, antidepressants, and gabapentinoids”
Long-Term Inhaled Cannabis Therapy for Chronic Low Back Pain: A Five-Year Retrospective Analysis of Prospectively Collected Patient-Reported Outcomes in 241 Treatment-Refractory Patients
https://www.mdpi.com/2227-9059/14/6/1255

For people with pain after a knee replacement, a 25:1 CBD:THC oil reduced levels of moderate-to-severe pain over the next 26 weeks
Cannabis to Reduce Chronic Postsurgical Pain Following Total Knee Arthroplasty: A Pilot Randomized Controlled Trial
https://assets-eu.researchsquare.com/files/rs-9622221/v1/8906402d-02a2-4971-80a3-319ed3604811.pdf?c=1780384340

In horse feed contaminated by low levels of CBD & CBDA, the horses had low but detectable levels in their plasma & urine
Plasma and urinary exposure of cannabidiol and cannabidiolic acid in horses following consumption of contaminated feed
https://link.springer.com/article/10.1186/s13620-026-00350-6

⚠️ Harms ⚠️

In first-episode psychosis, those with cannabis exposure “exhibited better cognitive function, lower cortical E/I balance, lesser negative symptoms, and greater mood symptoms”, with cannabis resumption associated with relapse
Cognitive, Electrophysiological, and Behavioral Presentation of First-Episode Psychosis With or Without Cannabis Exposure
https://psychiatryonline.org/doi/abs/10.1176/appi.ajp.20250726

For cannabis-associated violence, a review of case reports argued that more research is needed on this topic (#Sikhs)
Cannabis, Psychosis, and Violence: Case Reports and Comprehensive Evidence Review
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1824748/abstract
This article is behind a paywall so I’m not sure if they covered it, but there is a whole literature from the 50s (reviewed here by the historian Ernest Abel) about cannabis increasing violence in animals. And to go along with that, there’s plenty of sociological evidence from that time of Reefer Madness that if you tell young men who like to fight that cannabis will make them more wild & better at fighting, then that’s what it’s going to do. I have a whole chapter in my graphic novel series planned out about the history of violence & cannabis use, such as among the Sikhs, the great warriors of India, whose hero Gobind Singh once single-handedly defeated a battle elephant with a sword in its trunk after drinking a mixture of cannabis & opium.

📑 Reviews 📑

For anxiety, a review of 5 studies of THC-rich cannabis
Effectiveness and safety of cannabis on anxiety treatment outcomes: a systematic review
https://www.sciencedirect.com/science/article/pii/S2666915326000740

For inflammatory bowel diseases, a review of 8 trials on THC-rich cannabis
Effectiveness of THC-containing cannabis for inflammatory bowel disease: a systematic review
https://link.springer.com/article/10.1186/s42238-026-00456-2

For cannabis & PTSD, on the demographics of users & the patchy data
Post-Traumatic Stress Disorder & Cannabis: An Epidemiologic and Genetic Narrative Review
https://www.preprints.org/frontend/manuscript/b1934f6a35a6d034a13d358ea33afe24/download_pub

For synthetic drugs of the CB1 receptor in clinical trials, a review of 189 molecules
Synthetic CB1 Modulators in Clinical Trials: A Medicinal Chemistry Review
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.70302

In zebrafish, a review on the endocannabinoid system’s involvement in reproduction & the reaction to environmental pollutants
Role of the endocannabinoid system in teleostei fish physiology: implications for reproduction and environmental interactions
https://www.scielo.br/j/bjb/a/mdTGZ8L3bBssYCWZyZCcSRc/?lang=en

🐁 Preclinical 🐁

In a rat model of metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as fatty liver disease), cannabis oil lessened the inflammation, liver scarring & other negative effects
Cannabis oil prevents early hepatic fibrosis, inflammation and endothelial dysfunction in a sucrose-rich dietinduced MASLD model: role of cannabinoid receptors
https://karger.com/mca/article-pdf/doi/10.1159/000552533/4544010/000552533.pdf

In a rat model of Alzheimer’s disease, CBD improved spatial learning, memory & levels of pathological tau in the hippocampus (a memory center of the brain)
Cannabidiol attenuates tau hyperphosphorylation and cognitive deficits in an experimental model of Alzheimer’s disease and is associated with restoration of PP2A expression
https://link.springer.com/article/10.1007/s11011-026-01894-w

In a rat model of obesity, CBG lowered the influx of fatty acids, protected against excess lipids & improved antioxidant defenses in the mitochondria (powerhouse of the cell)
Cannabigerol Alleviates Obesity-Induced Mitochondrial Dysfunction by Cardiolipin Fatty Acid Remodeling
https://pubmed.ncbi.nlm.nih.gov/42233524/

For the bacteria that causes stomach ulcers, cannabis extracts caused inhibition & synergized with both kratom & Indian gooseberry
A study on the anti-Helicobacter pylori activity of three medicinal plant crude extracts from Cannabis sativa, Mitragyna speciosa and Phyllanthus emblica
https://repository.li.mahidol.ac.th/items/f276664e-0bda-4695-8640-f60ae94ee531

On myrcene, a thesis project on its painkilling properties
A common terpene engages the endocannabinoid system to alleviate chronic pain
https://escholarship.org/uc/item/04b7z4z0

🆕 Novel Studies 🆕

(a grab bag section for cool & new stuff)

For cannabis strains, on using Leafly user reviews for tracking their popularity
Surveillance of Cannabis Strains Using Online Data: Observational Study
https://formative.jmir.org/2026/1/e89897

For passive hair exposure of THC & CBD, even briefly sitting inside a vehicle with cannabis smoke can trigger a false positive for active use (#passive)
Methodological considerations on repeated measures and sub-LOQ values in passive cannabis hair contamination
https://www.sciencedirect.com/science/article/abs/pii/S0379073826002173

Lex’s roundup of fav newsletters:
#Canna: Marijuana Moment, Cannabis Law Report, Cultivated, Cannabis Musings (oy vey), Talking Joints Memo, Sticky Bits, Highly Objective, Cannabitch, Indigenous Cannabis Industry Association, Dr. Peter Grinspoon, Doctor Approved, Medical Marijuana Memory Blog (by Dame Alice O’Leary Randall)
#DrugWar: InSight Crime, Marshall Project, Students for Sensible Drug Policy
#HarmReduction: Filter, Drug Data Decoded, International Drug Policy Consortium, National Harm Reduction Coalition, Canadian Drug Policy Coalition
#Psychoactives: Psychedelic Alpha, Ecstatic Integration, ICEERS, Substance, The Microdose

📰 US Headlines & Fav Articles

The White House said it wants Congress to amend a law that, in November, will federally recriminalize hemp-derived full-spectrum CBD products
https://www.marijuanamoment.net/white-house-pushes-congress-to-keep-hemp-cbd-products-legal-by-amending-broad-ban-thats-set-to-take-effect-later-this-year/

In Maine & Massachusetts, the anti-cannabis ballot campaigns were accused of fraudulent & misleading tactics, with video evidence
https://www.marijuanamoment.net/anti-marijuana-ballot-campaigns-in-maine-and-massachusetts-accused-of-fraudulent-and-misleading-petitioning-tactics/

🌐 International Updates 🌐

In Spain, the Health Secretary said the government is not open to the legalization of adult-use cannabis, which is very funny because they have perhaps the world’s most flourishing network of gray-market cannabis clubs
https://www.democrata.es/en/health/padilla-rejects-legalizing-recreational-cannabis-and-claims-its-use-only-for-medical-purposes/

In Indonesia, on the dilemma of medical cannabis
The Medical Cannabis Dilemma in Indonesia: Its History, Benefits, and Risks from an Islamic Legal Perspective
https://journal.iaincurup.ac.id/index.php/alistinbath/article/view/14758

In Thailand, on tourism & the resistance to cannabis businesses
Unravelling tourists’ and residents’ appraisals to unethical cannabis-related businesses and their impact on resistance behaviours in tourism cities
https://www.tandfonline.com/doi/pdf/10.1080/20565607.2026.2681863

⚖️ Business, Laws & Education ⚖️

On the New York Stock Exchange, Trulieve became the first multistate cannabis operator to ring the bell & get uplisted after separating its adult-use assets from its medical business
https://www.cultivated.news/p/trulieve-rings-the-nyse-bell
https://cannabismusings.substack.com/p/cannabis-musings-june-9-2026

In an analysis of US cannabis taxes, increased taxes raised the price of products & reduced legal cannabis sales
The impact of taxes on prices and the demand for legally sold recreational Cannabis in the U.S.-An economic evaluation
https://pubmed.ncbi.nlm.nih.gov/42230272/

For hemp in the US, an economic analysis of its adoption in the economy with a focus on fiber
Quantifying the Economywide Impacts of Industrial Hemp Adoption in the U.S.
https://ageconsearch.umn.edu/record/361204?v=pdf

In young adults exposed to cannabis ads & warnings, on the effects of message complexity
Impact of Simple Versus Complex Cannabis Advertising Messages and Warnings on US Young Adults’ Product Perceptions
https://journals.sagepub.com/doi/abs/10.1177/29767342261454137

🚓 The War on Drugs 🚓

In Trump’s boat strikes, the very first one probably killed victims of human trafficking (#boatstrike)
Top Pentagon Official Admits Boat Strike May Have Killed Victims of Human Trafficking
https://theintercept.com/2026/06/10/trump-boat-strikes-human-trafficking-victims/
This whole article is worth reading. Not only are these extrajudicial killings illegal & inhumane, they are also terribly carried out.

In Venezuela, Trump said the US killed a Tren de Aragua leader in an airstrike
https://www.cbsnews.com/news/trump-says-u-s-killed-tren-de-aragua-leader-airstrike-nino-guerrero/

In the US, federal cannabis trafficking cases fell to another record low with just 383 in the last fiscal year
https://www.marijuanamoment.net/federal-marijuana-prosecutions-hit-another-record-low-in-2025-as-state-legalization-expands-government-report-shows/

In Europe, they just released a report on their drug situation
https://www.euda.europa.eu/publications/european-drug-report/2026/drug-situation-in-europe-up-to-2026_en

A new book on the war on drugs focused on the US & Mexico in the late 20th century
Policing on Drugs: The United States, Mexico, and the Origins of the Modern Drug War, 1969–2000 by Aileen Teague (review)
https://muse.jhu.edu/pub/12/article/991522/summary
Since the next chapters of my graphic novel series that I’m writing now are on the origins of the Mexican War on Drugs & how they played out over the last century, I just put this book in my basket.

In Fiji, 47k cannabis plants uprooted with an estimated street value of $47M
https://cannabislaw.report/fiji-47m-worth-marijuana-plants-uprooted/

In Spain, a cannabis club was dismantled for operating as a retail drug store
https://cannabislaw.report/cannabis-club-in-granadilla-tenerife-dismantled-for-operating-as-a-retail-drug-outlet/

In Mexico, a new cross-border tunnel found in Tijuana was 1900 feet long & had a rail system
https://www.aol.com/news/mexican-authorities-uncover-cross-border-002515092.html

In Paraguay, a private jet was found with 577 pounds of hashish & cannabis aboard after the pilot fled the country
https://cannabislaw.report/entrepreneur-pilot-leaves-paraguay-before-3-6m-in-hashish-found/

In Cambodia, a British national arrested with 65 kg of cannabis
https://cannabislaw.report/british-national-arrested-with-65kg-of-marijuana-during-phnom-penh-condo-raid/

In Indonesia, an Australian woman found with 59 mL of cannabis vape liquid is facing 20 years in prison
https://cannabislaw.report/australian-woman-faces-jail-time-over-alleged-cannabis-vape-liquid-in-indonesia/

WoD Research

For Baltimore police & cannabis laws, interviews found that they opposed zero-tolerance criminalization but criticized the current models of cannabis legalization
Police experiences with cannabis legalization and perceptions of broader drug policy reform
https://pubmed.ncbi.nlm.nih.gov/42236387/

In Oregon during their drug decriminalization laws, an analysis found immediate declines in both misdemeanor & felony charges, but “of those not dismissed, there appears to be a concerted effort on prosecuting those charges”
A longitudinal examination of the effects of drug policy shifts on PCS charging practices in Oregon
https://onlinelibrary.wiley.com/doi/abs/10.1111/1745-9133.70024

In South America, on the emergence of new synthetic drugs
Emergence of synthetic drugs in South America: insights from Brazil, Chile, and Colombia
https://link.springer.com/article/10.1186/s12954-026-01480-4

On Dark Web markets versus Reddit on talking about drug use
Substance Use Communication Across Public and Public Online Health Communities: Comparing Reddit and the Dark Web Forum Dread
https://scholars.cityu.edu.hk/en/publications/substance-use-communication-across-public-and-public-online-healt/

For NGOs during the Mexican War on Drugs, a thesis project on their role within the conflict
THE ROLE OF NGOS DURING THE MEXICAN WAR ON DRUGS
https://portalcris.vdu.lt/server/api/core/bitstreams/2041ae5e-a0b6-47b9-ad32-0ff0751fd1dd/content

For women drug dealers in Chile, a thesis project on their labor market trajectories
Precarious and gendered work: Labour market trajectories of women drug dealers in Chile
https://research-information.bris.ac.uk/ws/portalfiles/portal/488541404/Final_Copy_2026_03_17_Ortuzar_Madrid_C_PhD_Redacted.pdf

🛡️ Harm Reduction News 🛡️

In Canada, a ride-along with the underground “hit doctors” who inject drugs into people as a harm reduction service/business (#hitdoctors)
Meet the ‘hit doctor’: Inside an informal network of drug users trying to stay alive
https://www.cbc.ca/news/canada/british-columbia/inside-an-informal-network-of-drug-users-trying-to-stay-alive-9.7225457

Harm Reduction Research

For a hospital-based harm reduction program, interviews on operational barriers, tensions & educational gaps
Implementation and sustainability of hospital-based harm reduction delivery: a qualitative analysis
https://link.springer.com/article/10.1186/s12954-026-01476-0

In acute care health care professionals, a review of their views on harm reduction found they were generally willing to engage with interventions but this willingness did not always translate into action
Perspectives of Acute Care Health Care Professionals on Harm Reduction Interventions: A Scoping Review
https://journals.lww.com/cja/abstract/2026/06000/perspectives_of_acute_care_health_care.3.aspx

For drug houses, a thesis project interviewing people who use them
“IT’S THE SCARIEST, SAFEST ENVIRONMENT YOU’LL EVER BE IN”: AN EXPLORATORY STUDY OF DANGER AND SAFETY FOR PEOPLE WHO ACCESS DRUG HOUSES IN SASKATOON, SASKATCHEWAN, CANADA
https://harvest.usask.ca/server/api/core/bitstreams/7e4ab3a3-2c4f-403a-8ca0-ad28689c494c/content

🍄 Psychoactives, Psychedelics & Plant Medicines 🍄

On kratom for opioid use disorder, the FDA just greenlit the first human trial
https://filtermag.org/fda-human-trial-kratom-opioid-use-disorder/

A book review of mixing psychoactive substances with religion found this one to be lacking in the basics
Sacred Drugs: How Psychoactive Substances Mix with Religious Life
https://www.tandfonline.com/doi/full/10.1080/13537903.2026.2676394

Psychedelics & MDMA

On advocating for using full psilocybin mushroom extracts instead of the isolated psilocybin molecule
Time to embrace the whole: considering the replacement of psilocybin with Psilocybe spp. in psychedelic research and therapy
https://www.tandfonline.com/doi/abs/10.1080/14786419.2026.2683121

For MDMA & boosters, a trial found that they prolonged the acute subjective effects without increasing adverse events
Comparison of acute effects of 3,4- methylenedioxymethamphetamine (MDMA) with and without a supplemental booster dose in healthy participants: a double-blind, randomized, placebo-controlled, crossover study
https://www.nature.com/articles/s41398-026-04148-6_reference.pdf

For music & psychedelic therapy, a review of modern & traditional practices
Optimizing music for psychedelic-assisted therapy: Examining contemporary practices, traditional entheogenic rituals, and musically-induced peak experiences
https://www.akjournals.com/view/journals/2054/aop/article-10.1556-2054.2026.00523/article-10.1556-2054.2026.00523.xml

For the Indigenous use of ayahuasca for addiction, a review of 19 studies
A scoping review of ayahuasca-assisted therapy for Indigenous people living with addictions: gaps, lessons learned and policy implications
https://www.tandfonline.com/doi/full/10.1080/09687637.2026.2681541

In Brazil, a review of their 18 studies on psychedelics with a focus on ayahuasca
A trip through the psychiatric use of psychedelics in Brazil: A scoping review
https://www.sciencedirect.com/science/article/pii/S2950484826000172

For personality traits & the effects of psychedelics, a review of 48 studies found increases in openness & reductions in neuroticism to be the most consistent findings
Classic psychedelics and personality: An updated systematic review
https://journals.sagepub.com/doi/abs/10.1177/02698811261449386
“The most consistent findings were increases in Openness and reductions in Neuroticism, especially with psilocybin and ayahuasca. Changes in other traits, such as Extraversion, Agreeableness, and Conscientiousness, were more variable. Microdosing was associated with modest reductions in Neuroticism and higher Absorption.”

For cognitive flexibility & psychedelics, this review looked at the mixed findings
Psychedelics do not always enhance cognitive flexibility: The potential role of time-varying effects on reward learning processes
https://www.sciencedirect.com/science/article/abs/pii/S0149763426002459

Ketamine

In adolescents with suicidal ideation, a pilot trial of ketamine found a high participation rate & no serious adverse events
A pilot randomized trial of ketamine for suicidal ideation in a pediatric emergency department
https://link.springer.com/article/10.1007/s43678-026-01190-7

For oral ketamine, a review of 18 trials found the adverse effects to be predominantly mild & transient
Safety and tolerance of oral ketamine: A systematic review
https://onlinelibrary.wiley.com/doi/pdf/10.1111/pcn.70091
“Comparative analyses indicated higher rates of dizziness, sedation, and dissociative symptoms with ketamine, while serious adverse events were rare. Overall, oral ketamine demonstrates a favorable short-term safety profile.”

Kratom

For kratom, a review of its potency variations across Southeast Asia
Variations of Mitragynine Content in Kratom Leaves From Southeast Asia: An Updated Review
https://onlinelibrary.wiley.com/doi/abs/10.1002/cbdv.202502332

🍃 The Plant & its Products 🍃

🌱 Growing 🌱

For salt-stressed hemp, comparing the efficacy of cold plasma & metal nanoparticles seed priming to counter the stress
Cold plasma, Fe and Mn nanoparticles modulate antioxidant activity, cannabinoids gene expression, and fatty acid profile in salt-stressed hemp
https://www.nature.com/articles/s41598-026-56414-8_reference.pdf

For hemp in soil with heavy metals, on the response to inoculation with growth-promoting microorganisms
Sorghum and Hemp Responses to Plant Growth-Promoting Microorganism Inoculation in Metal-Contaminated Dredged Sediment: A System-Level Assessment Under Environmentally Relevant Outdoor Pot Conditions
https://www.mdpi.com/2039-4713/16/3/102

An analysis of cannabis tetraploids (4 copies of the genome)
Advances on tetraploid Cannabis sativa L.: Morpho-anatomy, ionomics and chemical profile
https://www.sciencedirect.com/science/article/pii/S0926669026009647
In agronomy, adding more duplicates of the genome is a common technique for improved yield. Unfortunately, due to Prohibition, cannabis has had less time to benefit from this type of agricultural science.

For terpene levels in leaves, an analysis of the effects of growing season, leaf maturity & cultivation method
Impact of Internal and External Factors on Terpenoid Profiles in Cannabis sativa Leaves: Metabolomic Approach
https://www.researchgate.net/publication/405446164_Impact_of_Internal_and_External_Factors_on_Terpenoid_Profiles_in_Cannabis_sativa_Leaves_Metabolomic_Approach

In cannabis stalks, a dataset of their proteome & transcriptome
Raw proteomic and transcriptomic data: Cannabis glandular trichome stalks
https://researchportal.scu.edu.au/esploro/outputs/dataset/Raw-proteomic-and-transcriptomic-data-Cannabis/991013371959702368

On cannabis grown in Nigeria, a lipid profile analysis of its roots, stems, leaves & seeds
Lipid Profile of Four Parts (Roots, Stem, Leaves, and Seeds) of Cannabis sativa Grown in Nigeria: Part I.
https://openurl.ebsco.com/EPDB%3Agcd%3A3%3A31129347/detailv2?id=ebsco%3Agcd%3A193898258&crl=f&jrnl=26160684

⚙️ Extracting, Analyzing & Formulating ⚙️

For cannabis extraction, a review comparing the various methods
From Plant to Extract: Different Factors in the Extraction of Cannabis sativa L. Inflorescences
https://journals.sagepub.com/doi/abs/10.1177/25785125261454834

For rapid CBD level analysis, a comparison of 3 different methods
Comparing the Utility of Cannabidiol Quantitation Methods for Use in High-Throughput In Vitro Assays
https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c12618

For dried cannabis flowers, a test of stability found no significant degradation after 9 months
STABILITY STUDY OF DRIED CANNABIS FLOWER
https://ojs.ikm.mk/index.php/kij/article/view/8357

For CBD dry powder formulations, a thesis project on formulation strategies
Cannabidiol dry powder formulations
https://ourarchive.otago.ac.nz/esploro/outputs/doctoral/Cannabidiol-dry-powder-formulations/9926865622101891

🍞 Food & Nutrition 🍞

For hemp as a dairy alternative, an evaluation of different types of water for creating cheese analogues
Systematic evaluation of hemp-based dairy alternatives: how processing water shapes the quality of milk and the characteristics of developed cheese analogs
https://link.springer.com/article/10.1007/s11694-026-04526-0

For Scottish cold-pressed hemp seed oil & its by-products, an analysis of their functional properties for food systems
Nutritional composition and functional properties of Scottish cold-pressed hemp oil and by-products for sustainable food applications
https://www.sciencedirect.com/science/article/pii/S2590259826000282

On the properties of hemp protein hydrolysates & corn starch complexes
Influence of hemp protein hydrolysates on the textural, thermal, rheological, and structural properties of corn starch with varying amylose content
https://www.sciencedirect.com/science/article/pii/S2213329126000365

On improving composite gels made of hemp seed protein hydrolysate
Physicochemical and Structural Characterization of Composite Gels of Commercial Hemp Seed Protein Concentrate and Hemp Seed Protein Hydrolysate
https://www.mdpi.com/2310-2861/12/6/484

🏗️ Industrial Uses & Fiber 🏗️

For hemp biodiesel with nanoadditives, a machine learning analysis of emissions & performance
Machine learning based prediction of diesel engine emissions and performance using hemp biodiesel enriched with nano additives
https://www.nature.com/articles/s41598-026-49243-2_reference.pdf

For aerospace composites reinforced with hemp, an analysis of fracture behavior & structural integrity
Fracture behaviour and structural integrity of hemp fibre reinforced composites for low load-bearing aerospace applications
https://www.nature.com/articles/s41598-026-44443-2

For hemp composites, on methods for micro-machining
Micro-scale machining response of unidirectional hemp fiber-reinforced bio-PBS composites
https://www.tandfonline.com/doi/full/10.1080/10426914.2026.2682777

In an analysis of epoxy composites made with hemp & filled with red brick dust using machine learning
Mechanical and tribological response of red brick dust filled hemp-epoxy composites using response surface methodology and machine learning approach
https://www.nature.com/articles/s41598-026-53725-8_reference.pdf

On reinforcing hemp concrete with flax textile, an analysis of the effects of different configurations on compression & shear loading
Strengthening of hemp concrete with vegetal fabric reinforced cementitious matrix: experimental study on compression and shear behaviour
https://www.sciencedirect.com/science/article/abs/pii/S2352710226012647

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

🏥 Public Health & Bioassays 🏥

For people who combine cannabis & cigar/cigarillos, an analysis of their demographics
The Association Between Sociodemographic Factors and co-Use of Cigars or Cigarillos with Cannabis
https://www.tandfonline.com/doi/pdf/10.1080/10826084.2026.2675987

In Bulgarian healthcare professionals, a survey of the readiness for recommending CBD products
ASSESSING THE READINESS OF HEALTHCARE PROFESSIONALS FOR PRESCRIBING AND DISPENSING CANNABIDIOL PRODUCTS IN BULGARIA
https://ojs.ikm.mk/index.php/kij/article/view/8358

For drug testing, an analysis of the effects from the liver breaking down THC into its metabolites
In Vitro Metabolism of Δ8-, Δ9-, and Δ10-THC in Human Hepatocytes: Distinct Δ10-THC Biotransformation and Implications for Drug Testing
https://pubmed.ncbi.nlm.nih.gov/42229946/

🧒 Adolescents & Young Adults 🧒

For reducing cannabis use in youth, mindfulness-based cognitive behavioral therapy reduced cravings & improved mindfulness & emotional regulation
RISK ASSOCIATED WITH MARIJUANA AND THE EFFECTIVENESS OF MINDFULNESS BASED COGNITIVE BEHAVIORAL THERAPY IN THE TREATMENT OF ADDICTION AMONG YOUTHS IN SELECTED REHABILITATION CENTRES IN KENYA
https://ajoeijournal.org/sys/index.php/ajoei/article/view/1161

In young adult females using cannabis, coping motives were associated with longer & higher subjective intoxication but only in solitary settings
Do motives for and contexts of cannabis use interact to predict heavy cannabis use at the event-level?
https://pubmed.ncbi.nlm.nih.gov/42237465/

In young adult women, on their profiles of co-using alcohol & cannabis & the effects on their coping & perceived well-being
Gender-Sensitive Coping–Well-Being Profiles Associated with Alcohol and Cannabis Co-Use Among Young Adult Women
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2670631

🧠 The Brain & Neurological Disorders 🧠

In a mouse model of Parkinson’s disease, the neuroprotective effects of exercise were mediated by crosstalk between dopamine & the endocannabinoids
Dopamine–endocannabinoid crosstalk drives exercise-induced bidirectional plasticity in Parkinson’s disease
https://www.nature.com/articles/s41531-026-01396-7_reference.pdf

In a mouse model of blood-brain barrier dysfunction, activating the CB2 receptor with a novel drug reduced neuroinflammation-associated dysfunction & white blood cell trafficking
Orally bioavailable CB2 receptor agonists attenuate neuroinflammation and stabilize the blood–brain barrier
https://www.researchsquare.com/article/rs-9705876/v1

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

In people at risk for cannabis use disorder participating in a cannabis cue stop-signal task (a measure of whether cannabis images alter your reaction times or executive control), they had no differences in inhibitory controls or prefrontal activation versus people at low risk
No differences in inhibitory control or prefrontal activation during a cannabis cue stop-signal task across CUDIT-R-defined CUD-risk groups
https://link.springer.com/article/10.1007/s00213-026-07099-4

For measuring cannabis craving, on the validation of a short form questionnaire
Validation and measurement invariance of a modified version of the marijuana craving questionnaire-short form across community and clinical samples
https://pubmed.ncbi.nlm.nih.gov/42225013/

🧬 Reproduction & Hormones 🧬

In a rat model of prenatal THC exposure, dietary long-chain ω-3 polyunsaturated fatty acids prevented the memory impairment in both sexes, while in males they counteracted the synaptic hyperexcitability & in females they rebalanced the inhibitory shift
Perinatal LC-ω-3-PUFA supplementation offsets prenatal THC-induced cognitive deficit via sex-specific modulation of hippocampal neuroplasticity
https://pubmed.ncbi.nlm.nih.gov/42229740/

In a placental tissue model of gestational diabetes, the endocannabinoids mediated the changes in placental circulation
ENDOCANNABINOID MEDIATED PLACENTAL VASCULAR RESPONSES IN GESTATIONAL DIABETES MELLITUS
https://journals.lww.com/jhypertension/fulltext/2026/04001/endocannabinoid_mediated_placental_vascular.34.aspx

🍽️ The Guts, Nutrition & the Microbiome 🍽️

In a mouse model of colitis, seal oil increased intestinal permeability & reduced inflammation markers while both fish oil & seal oil protected from some of the changes to endocannabinoid & oxylipin levels, with 2-eicosapentaenoyl glycerol being a defining lipid
Seal and fish oils partially counteract inflammation and modulate endocannabinoidome lipid and oxylipin alterations in DSS-induced colitis
https://www.nature.com/articles/s41598-026-54447-7_reference.pdf

🖐️ The Skin & Topicals 🖐️

In human skin cells, a complex of CBD & a tyrosinase inhibitor caused antioxidant activity
Cannabidiol-thiosemicarbazone exhibits dual tyrosinase inhibition and antioxidant activity in human skin-derived cells
https://pubmed.ncbi.nlm.nih.gov/42235859/

🎗️ Cancer & Chemotherapy 🎗️

For cancer drugs, coverage of an early-stage CB2 receptor antagonist from Teon Therapeutics
https://cannabinoidpipelineinsights.substack.com/p/cannabinoid-r-and-d-and-cancer-research

💊 Synthetic Cannabinoids & Hemp-Derived Cannabinoids 💊

For 3 synthetic cannabinoids, an analysis of their breakdown products
In vitro metabolic profile characterization for synthetic cannabinoids MDMB-BINACA, MDMB-PICA, and AB-CHMINACA
https://academic.oup.com/jat/advance-article-abstract/doi/10.1093/jat/bkag034/8699621

🔬 Biochemical Discoveries & Research Tools 🔬

On creating a nanosponge for delivering a drug to activate the CB2 receptor
Cyclodextrin-based nanosponges for the solubility enhancement and delivery of a selective CB2 receptor ligand
https://www.sciencedirect.com/science/article/abs/pii/S1773224726005642

Thanks.
- lex

PS: For this week’s country-soul pioneer, Arthur Alexander & his debut album ‘You Better Move On’. This son of a bottleneck blues guitarist in Alabama, Arthur Alexander had joined a gospel group by the age of 12. After high school he began writing songs for sale to record labels & in 1962, Alexander released his own classic song “You Better Move On” (later covered by the Rolling Stones). Despite mishandling by Dot Records, his third single “Anna (Go To Him)” broke the R&B Top 10 & was later covered by his big fans, the Beatles. He spent the ‘60s & ‘70s writing music for others, though sometimes dropping out due to ill health. He eventually retired from the music business. He made a comeback album in 1993 but suffered a fatal heart attack just as the tour began. Many bands looked to him for their R&B sound & he was covered by everyone from Bob Dylan to Otis Redding & Tina Turner to Pearl Jam. As music critic Jason Ankeny stated, “his music is the stuff of genius, a poignant and deeply intimate body of work on par with the best of his contemporaries.”

This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.
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Alzheimer’s, spinal cord neuropathy, cancer & personality traits

Lex Pelger WhiteWhaleCreations — Mon, 08 Jun 2026 12:28:48 GMT

Cannabinoids & The People,
or; Drugs & Drug Wars

🌟 This Week 🌟

(#hashtags for jumping to articles by searching for them with your browser)

Cannabinoids for the agitation of Alzheimer’s disease
CBD for children with autism & for the neuropathic of a spinal cord injury
Cannabis for the chronic pain of hypermobility
For cancer, one study on CBD & one on cannabis
On personality traits & cannabis usage, neurotics use it to cope & those with openness use it to explore
Effects of cannabis smoking on the lungs
Profile of endocannabinoid hero Rita Levi-Montalcini (#rita)
Preclinical: CBD for cognitive decline for chemotherapy, age-related muscle decline, enhancing the painkilling effects of oxycodone & improving the efficacy of antibiotics
Ketamine for substance use disorders
Psychedelics: ibogaine for opioid dependence & psilocybin for long-term antidepressant effects
War on Drugs: deep-dive on 2 sitting Mexican governors under US investigation

[numbers for C&P#190: ~6.5k words, ~17 minutes reading time, 124 papers]

Hello everyone,
Welcome to the 190^th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news + the War on Drugs, harm reduction & other psychoactives. Support this work with a paid subscription or by buying me a coffee. If you purchase one of my canna-graphic novels based on Moby Dick, proceeds go to Americans for Safe Access to support medical cannabis patients.
For producing cannabinoid content, work with my company White Whale Creations: writing, science archives, social media, newsletters & podcasts.
As always, ask me anything!

🤝 Sponsor 🤝:
The Cannabis & Health Research Initiative

Want to help expand the knowledge of medical cannabis use in the real world & get paid 100 bucks to do so?

Follow along on Instagram to keep on learning or sign up for the monthly CHRI email (curated by me) to get just the best of clinical research & new reviews twice a month.

🎥 Lex’s new work 🎤

@CannabinoidsAndThePeople on YouTube, TikTok & LinkedIn
Canna-edu videos sponsored by the National Cannabis Study (join & get paid $100 to talk about your use of our favorite plant)
- nothing new this week. working on a big one on CBD & the EU’s declaration of it as a reproductive toxicant

Canna-science Videos for CV Sciences on YT @CVSciencesInc & on TT @pluscbd
For 30% off their CBD, THC & PEA products, at pluscbdoil.com use the coupon code ‘LEX’

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Whitman on death

And as always, at the bottom is the album of the week: our hero Mose Allison!

💖 Ways to support this work 💖

- Venmo: @Lex-Pelger

- PayPal: donate here

📣 A request to spread the word 📣

This newsletter only spreads by word of mouth, so please share to friends & colleagues.

🍃 BEST OF CANNABINOID SCIENCE 🍃

(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)

A capsule biography of endocannabinoid hero Rita Levi-Montalcini, the discoverer of the mechanisms used by the endocannabinoid PEA & a recipient of the Nobel Prize
From the Scientific Underground to the Height of Recognition: The 40th Anniversary of Rita Levi-Montalcini’s Nobel Prize and the Promising Horizon in Psychiatry
https://link.springer.com/article/10.1007/s11064-026-04769-9

⚕️ Clinical ⚕️

For the agitation of Alzheimer’s disease, a meta-analysis of 7 studies found cannabinoids lowered neuropsychiatric symptoms & agitation scores
Cannabinoids Treatment for Agitation in Alzheimer’s Disease: A Systematic Review and Meta-Analysis with Bayesian and Sequential Trial Analyses
https://www.ajgponline.org/article/S1064-7481(26)00400-8/abstract

For neuropathic pain from a spinal cord injury, a trial of high-dose CBD isolate found it significantly reduced the self-reported intensity of neuropathic pain & was generally well tolerated
High-dose cannabidiol for chronic neuropathic pain associated with spinal cord injury: a randomised clinical trial
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(26)00234-8/fulltext

In children with autism, CBD isolate improved irritability, tantrums, restricted & repetitive behaviors, sociality, anxiety & sleep problems
A Phase-2 Open-Label Trial of Cannabidiol to Treat Core and Associated Symptoms of Autism in Children and Adolescents Without Intellectual Disability
https://journals.sagepub.com/doi/abs/10.1177/10445463261452514

For chronic pain from hypermobility, a case series from the UK Medical Cannabis Registry found that the initiation of cannabis-based medicines improved all patient-reported outcomes with significant improvements in pain severity & interference
UK Medical Cannabis Registry: an updated analysis of clinical outcomes of medicinal cannabis therapy for hypermobility-associated chronic pain
https://link.springer.com/article/10.1007/s10067-026-08166-z

For severe, drug-resistant pediatric epilepsies, a meta-analysis of 46 studies found CBD reduced seizures in ~ half of patients
Cannabidiol Use in Developmental and Epileptic Encephalopathies: A Syndrome- and Age-Stratified Systematic Review and Meta-analysis
https://link.springer.com/article/10.1007/s40263-026-01301-z

In people with cancer using cannabis for their symptoms, more than half reported significant relief across all symptom domains
Association of iterative cannabis care plans with rates of symptom relief and side effect burden in oncology patients
https://ascopubs.org/doi/abs/10.1200/JCO.2026.44.16_suppl.12070

For cancer survivors using CBD, a survey found that they used it for pain, insomnia, stress, depression & neuropathy
Cannabidiol and Cancer Survivors: Utilization and Experiences
https://journals.sagepub.com/doi/abs/10.1177/10966218261448666

For people with cancer, one-third of them used cannabis for symptom management & their household income & neighborhood disadvantage caused different effects on the help for their pain, sleep & anxiety
Associations between neighborhood disadvantage, cannabis use, and patient-reported outcomes among patients with cancer
https://www.sciencedirect.com/science/article/pii/S2772724626000429

For cannabis use & PTSD symptoms in combat veterans, this thesis project hypothesized that decreased use would improve mental health outcomes but in fact, “decreased cannabis use was associated with worsening PTSD symptoms, reduced quality of life, and decreased satisfaction with concentration”
Effects of Cannabis Use Reduction on PTSD Symptoms in Combat Veterans: An Ecological Momentary Assessment Study
https://www.proquest.com/openview/14beb7335d6ffca4d4a4356b09e3c76e/1?pq-origsite=gscholar&cbl=18750&diss=y

For personality traits & cannabis usage, neuroticism was associated with greater usage & related problems though coping motives, while openness was associated with greater usage through expansion motives
The mediating role of motives in the associations between the big five personality traits and marijuana outcomes: A cross-national study across four countries
https://www.sciencedirect.com/science/article/pii/S2352853226000489

In cows experiencing heat stress, they had significantly reduced levels of the endocannabinoid 2-AG
Effect of environmental temperature on oxidative status, inflammatory response and endocannabinoid system at oestrus in dairy cows
https://bvajournals.onlinelibrary.wiley.com/doi/pdf/10.1002/vro2.70037

⚠️ Harms ⚠️

For calls to the US Poison Center, there are more cases for cannabis than any other drug besides except for alcohol, benzodiazepines & heroin, with many cases involving adolescents, plus a 10x increase in unintentional exposures in children
U.S. Poison Center Exposure Cases Involving Marijuana and Selected Comparator Substances
https://www.sciencedirect.com/science/article/abs/pii/S0376871626001857

In European cannabis users, a review of public health data found rising use in Central & Eastern Europe, with consistent links to psychosis, anxiety, panic symptoms, derealization episodes & cannabis use disorder
Mental Health Consequences of Contemporary Cannabis Use in Europe: Potency, Patterns of Use, and Health System Context
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1778831/abstract

For preventing heart failure, a constellation of cardiology organizations put cannabis at the bottom of the risk-chart for cardiac risks from the most commonly used drugs
Prevention of heart failure: A scientific statement of the Heart Failure Association, the European Association of Preventive Cardiology, and the Association of Cardiovascular Nursing & Allied Professions of the ESC, and the ESC Council on Hypertension
https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag362/8698338
“Substance misuse, including alcohol, cannabis, opioids, and stimulants, is linked to higher HF prevalence and hospitalizations.132,133 Alcohol intake exceeding 70 g/week increases the risk of HF progression by 4.9 times,30 while cannabis, opioid, and stimulant users exhibit a 2.52-, 3.48-, and 3.35-fold higher HF prevalence, respectively.”

For cannabis smoking & the lungs, a review of effects compared to electronic cigarettes
Puff or pass? The truth about vaping, marijuana, and tobacco safety
https://www.ingentaconnect.com/contentone/ocean/jprm/2026/00000009/00000001/art00002
“Regular cannabis smoking is associated with chronic bronchitis symptoms, airway inflammation, and impaired mucociliary function, although its long-term impact on COPD or lung cancer risk remains less clearly established than that of tobacco.”

In cannabis-induced first-episode psychosis, the 3 trajectories identified were rapid recovery, gradual recovery & persistent impairment, with dissociative symptoms representing the most powerful predictors of functional recovery
Functional recovery trajectories in cannabis-induced first-episode psychosis: The role of dissociative symptoms in the discrepancy between symptomatic improvement and functional outcomes
https://www.sciencedirect.com/science/article/pii/S0165178126003008

In men with cannabis use disorder as well as methamphetamine use disorder, they had higher scores for anxiety, affective lability (intense shifts in emotional states) & impulsivity
2D:4D ratio, affective lability, and impulsivity in men with cannabinoid and methamphetamine use disorders: A comparative analysis with healthy controls
https://www.sciencedirect.com/science/article/abs/pii/S037837822600112X

For edibles causing prolonged neurological depression, a case report where the symptoms began 3 hours after ingestion & progressed to slurred speech & mental stupor by 12 hours
Prolonged Neurological Depression, Bradycardia, and Gastroparesis Following Acute Oral Cannabinoid Ingestion: A Case Report
https://assets.cureus.com/uploads/case_report/pdf/495587/20260526-156211-bkddct.pdf

For cannabinoid hyperemesis syndrome, a case report with special considerations for comorbidities like seizure disorders & poor mental health
Special Report: Clinical Considerations of Cannabis Use in the Inpatient Medical Setting
https://psychiatryonline.org/doi/full/10.1176/appi.pn.2026.06.6.6

For prenatal cannabis use links to birth defects, public health data found the risks to be greatest among African Americans, American Indians & Alaskan Natives
Cannabinoid impacts on ethnic modulation of atrial septal defect prevalence USA
https://www.nature.com/articles/s41372-026-02717-7

In a fetus with a heart arrhythmia (irregular heartbeat), a case report with a potential link to cannabis
Transient Fetal Nonimmune 2:1 Atrioventricular Block Possibly Secondary to Cannabis Exposure
https://www.sciencedirect.com/science/article/pii/S2468644126000940

In a rat model of prenatal THC exposure, the persistent deficits in synaptic plasticity & memory formation were caused by an imbalance of excitation & inhibition in the hippocampus (a memory center of the brain) via changes to GABA (the brain’s most common inhibitory neurotransmitter) & glutamate (the brain’s most common excitatory neurotransmitter)
Prenatal cannabinoid exposure alters excitation-inhibition balance through glutamate and GABA receptor-mediated signaling
https://www.sciencedirect.com/science/article/pii/S0021925826020685

📑 Reviews 📑

For CBD & the mucosa (linings of the insides of organs & body cavities), a review on CBD for targeting a range of diseases (good charts)
Cannabidiol for Mucosal Diseases: Therapeutic Potential and Advanced Delivery Strategies
https://www.mdpi.com/1999-4923/18/6/638

For medical cannabis knowledge & the risk for infections, a practical guide for clinicians
Current state of knowledge on medical cannabis use and risk for infections: A practical guide for clinicians
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciag343/8698442

For sleep physicians, a guide to what they need to know about the complexities of cannabis & slumber
What sleep physicians need to know about cannabis use for sleep
https://link.springer.com/article/10.1007/s44470-026-00095-7

For anesthesia & medical cannabis users, a review of an integrated approach for managing pain, pharmacology & anesthesia
Anesthesia and medical cannabis: an integrated approach
https://pubmed.ncbi.nlm.nih.gov/42187203/

On using endocannabinoid levels to predict clinical states, a review of the benefits of measuring endocannabinoid ratios instead of absolute levels
Ratio-based cannabinoid signalling – limitations of absolute endocannabinoid levels in predicting clinical states
https://www.jpccr.eu/pdf-221732-140080?filename=Ratio-based-cannabinoid-s.pdf

For cannabinoids & PTSD, a review of 26 studies found insufficient evidence
Efficacy, effectiveness and safety of medical cannabis in PTSD: a scoping review
https://link.springer.com/article/10.1186/s42238-026-00451-7

In skin melanocytes (that produce the melanin to color your skin) & melanoma (cancer) cells, UVA radiation increased oxidative stress while the cannabinoids CBG & CBD attenuated those changes & enhanced antioxidant defense
Metabolic Responses of Melanocytes and Melanoma Cells to UVA Radiation and Phytocannabinoids Exposure
https://www.mdpi.com/2076-3921/15/6/690

For treating psychiatric disorders, a review of enhancing anandamide levels by inhibition of the FAAH enzyme (which breaks down anandamide)
Enhancing anandamide signalling through fatty acid amide hydrolase inhibition: An update on the pharmacological strategy for treating psychiatric disorders
https://www.nature.com/articles/s41398-026-04120-4

For neuropsychiatric disorders & GPR55 (which may one day be known as CB3), a review of its interactions with dopamine & glutamate (the brain’s most common excitatory neurotransmitter) in preclinical models
Role of GPR55 in glutamatergic and dopaminergic signalling: a review of preclinical evidence in neuropsychiatric disorders
https://molpharm.aspetjournals.org/article/S0026-895X(26)00031-3/abstract

A new book with an intriguing array of articles on drugs & society
Research Handbook on Drugs and Society
https://www.e-elgar.com/shop/gbp/research-handbook-on-drugs-and-society-9781802209136.html
I’m still waiting to become influential enough to get books like these sent to me for free…

🐁 Preclinical 🐁

In older & younger mice, exposure to cannabis smoke caused increased inflammatory markers in the prefrontal cortex (highest area of brain), while in the hippocampus (a memory center of the brain), it caused increased inflammation in the younger mice but lowered inflammation in the older mice
Effects of sub-chronic cannabis smoke exposure on inflammatory markers in serum and brain in younger and older mice
https://www.sciencedirect.com/science/article/abs/pii/S019745802600093X

In a mouse model of cognitive decline from chemotherapy, one month of CBD caused significant neurocognitive improvements in learning, memory, executive function & memory consolidation while mitigating the loss of neuronal plasticity, synaptic density & neurogenesis (the birth of new brain cells)
Cannabidiol alleviates chemotherapy-induced cognitive decline and neuropathology
https://www.sciencedirect.com/science/article/pii/S0304383526003757

In rats taking oxycodone for pain, CBD enhanced the painkilling effect without increasing the symptoms of addiction
Selective opioid-sparing effects of cannabidiol on opioid analgesia in rats
https://www.jpain.org/article/S1526-5900(26)00156-2/abstract

In a mouse model of age-related muscle decline, CBD reduced inflammation, oxidative stress, DNA damage & muscle aging with benefits for the gut microbiome
Cannabidiol alleviates D-galactose-induced muscle tissue aging in mice by modulating oxidative stress and is associated with alterations in gut microbiota
https://www.sciencedirect.com/science/article/abs/pii/S2212429226008990

For bacteria resistant to antibiotics, the combination of CBD & the antibiotic diclofenac caused synergistic & additive effects
Combining Diclofenac and Cannabidiol to Enhance the Antibacterial Capacity of Nonantibiotics Drugs Through Potentiation
https://www.preprints.org/frontend/manuscript/928f120ab7cb59f7635e6a868a6aac24/download_pub

In blood immune cells of people with HIV, both THC & CBD suppressed inflammation & the formation of inflammasomes
Inflammasome formation and IL-1β secretion are reduced in peripheral blood monocytes from HIV+ cannabis users
https://www.sciencedirect.com/science/article/pii/S0022356526011511

In a tissue model of diabetes, THC, CBG & CBD inhibited the enzyme α-glucosidase (helps with control of type 2 diabetes)
Potent α-Glucosidase Inhibition by a Non-Psychoactive CBG/CBD-Rich Cannabis Extract
https://openurl.ebsco.com/EPDB%3Agcd%3A1%3A31129329/detailv2?sid=ebsco%3Aplink%3Acrawler-gcd&id=ebsco%3Agcd%3A193898239&crl=c&jrnl=26160684&link_origin=none

🆕 Novel Studies 🆕

(a grab bag section for cool & new stuff)

For imaging the enzyme MAGL (which breaks down the endocannabinoid 2-AG), the first study in humans using PET scans
First-in-Human PET Study with [18F]MAGL-2102 for Neuroimaging of Monoacylglycerol Lipase
https://jnm.snmjournals.org/content/67/supplement_1/261369.abstract

AHHH. After last week’s beautiful trilogy of endocannabinoids in cool animals, I’m distraught to see that in this paywalled paper, I can’t even tell which long-distance migrant they’re talking about: Bird? Whale? Butterfly? Fish? Ungulate? Reptile?
Fattening physiology in a long-distance migrant: interplay between baseline corticosterone, diet and the endocannabinoidome
https://www.journals.uchicago.edu/doi/abs/10.1086/742374

Lex’s roundup of fav newsletters:
#Canna: Marijuana Moment, Cannabis Law Report, Cultivated, Cannabis Musings (oy vey), Talking Joints Memo, Sticky Bits, Highly Objective, Cannabitch, Indigenous Cannabis Industry Association, Dr. Peter Grinspoon, Doctor Approved, Medical Marijuana Memory Blog (by Dame Alice O’Leary Randall)
#DrugWar: InSight Crime, Marshall Project, Students for Sensible Drug Policy
#HarmReduction: Filter, Drug Data Decoded, International Drug Policy Consortium, National Harm Reduction Coalition, Canadian Drug Policy Coalition
#Psychoactives: Psychedelic Alpha, Ecstatic Integration, ICEERS, Substance, The Microdose

📰 US Headlines & Fav Articles

In the WNBA, cannabis now removed from the banned substances list & players can endorse hemp CBD products
https://www.marijuanamoment.net/wnba-removes-marijuana-from-banned-substances-list-and-sets-rules-for-player-endorsements-of-hemp-cbd-products/

In Alabama, 5 years after the legalization of medical cannabis & a shitstorm of lawsuits, the first legal medical cannabis purchase ever was made
https://www.wsfa.com/2026/06/03/historic-day-patients-first-medical-marijuana-purchase-made-alabama-history/

In Louisiana, you can now go to jail for a year for smoking cannabis within 2000 feet of a school, even a college campus (apparently because the governor is tired of “being inundated with the smell of marijuana” at football games)
https://www.marijuanamoment.net/louisiana-governor-signs-bill-that-will-send-people-to-jail-for-smoking-marijuana-near-college-campuses/
https://www.marijuanamoment.net/louisiana-governor-is-tired-of-being-inundated-with-the-smell-of-marijuana-at-football-games-so-he-signed-a-bill-to-jail-people-for-it/

In Hawaii, the leading reason for being denied a gun permit is because of being a medical cannabis patient
https://www.marijuanamoment.net/more-people-are-denied-gun-permits-over-medical-marijuana-in-hawaii-than-for-any-other-reason-attorney-generals-report-shows/

In New York, medical cannabis operators are pleading with the state to not make them pay a $15M conversion fee to begin also serving the adult-use market, with 3 of the 10 businesses having already gone under
https://mjbizdaily.com/news/new-york-medical-cannabis-operators-owe-the-state-millions-they-claim-they-cant-afford/616246/

In detective fiction, a thesis project on their use of drugs
Detectives on Drugs: Contamination and Containment in U.S. Crime Fiction
https://www.proquest.com/openview/75c2b86281fe80072509e0fa7d549e94/1?pq-origsite=gscholar&cbl=18750&diss=y
This project focuses on modern US crime fiction, but the main thing I know is that Sherlock Holmes was super into cocaine.

For images of mushrooms in contemporary literature, a thesis project on the fungal imaginary
The Fungal Imaginary: Mushroom Motifs in Contemporary Literature
https://www.proquest.com/openview/99e96148e1c18fb16f6b55f77a140e58/1

🌐 International Updates 🌐

A deep-dive on a secret guideline from the International Narcotics Control Board in 2024 that CBD is not covered by international drug treaties & the extraction of uncontrolled cannabinoids falls into the category of industrial hemp
https://cannareporter.eu/en/2026/05/20/Exclusive-letter-from-INCB--kept-secret--reveals-that-CBD-is-outside-international-control./

Last year Germany imported 218+ tons of legal cannabis (but as Sean points out from my cannabis smuggling video linked there, that’s what San Francisco in the 1960s would use in just a few weeks)
https://cannabislaw.report/article-germany-imported-over-218-tons-of-legal-cannabis-in-one-year/

Across the 195 countries in the World Health Organization, this analysis compared their health warnings for alcohol, tobacco & cannabis, with the main finding being to strengthen warnings for alcohol
A comparison of labelling requirements for alcohol, tobacco, and cannabis across WHO regions and implications for alcohol labelling policy in Canada
https://www.sciencedirect.com/science/article/pii/S0955395926001921

⚖️ Business, Laws & Education ⚖️

On the RobinHood stock trading app, a few of the big cannabis companies showed up for the first time
https://app.moby.co/home/news/news-robinhood-is-opening-the-door-to-us-cannabis-with-reform-on-the-horizon
https://mjbizdaily.com/news/us-cannabis-stocks-are-trading-on-robinhood-what-does-it-mean/616260/

In California elected officials, a survey found that the top priorities were tax revenue, economic development & youth cannabis use, with low support for social equity
Cannabis policy priorities and public health: a survey of elected officials in California
https://link.springer.com/article/10.1186/s12889-026-27889-x

For intellectual property in the cannabis industry, a new book analyzing branding
A high-level analysis of the role of IP in the cannabis industry
https://academic.oup.com/jiplp/advance-article-abstract/doi/10.1093/jiplp/jpag060/8698124

For the American Disabilities Act & a case involving hemp extracts, a law thesis project on the complex question of chemical synthesis
High on Uncertainty: ADA Accommodation and Hemp-Derived Substances After Anderson v. Diamondback Investment Group, LLC
https://digitalcommons.law.umaryland.edu/cgi/viewcontent.cgi?article=1124&context=endnotes

In Thailand, a case study of integrating hemp into the value chain
Integration of the hemp value chain into local creative economy policy: A case study of Mae Hong Son, Thailand
https://academicjournals.org/journal/JDAE/article-full-text-pdf/1CF7E6074613.pdf

For mystery shoppers at cannabis retailers in 5 US states, the majority of stores requested ID, warned about driving post-use & made health claims such as help for anxiety & insomnia, while on use during pregnancy, some warned against it but the majority said it helps or it depends
Mystery shopper assessments of cannabis retailer practices and regulatory compliance in five U.S. states, 2025
https://www.sciencedirect.com/science/article/abs/pii/S0376871626001997

Across 11 US cities, despite prohibitions, many sold hemp-derived intoxicating cannabinoids and/or hallucinogenic mushrooms
Retail Availability of Intoxicating Cannabis and Mushroom Products Across Eleven U.S. Cities: Sales Persist Despite Prohibitions
https://www.jsad.com/doi/abs/10.15288/jsad.26-00013

For perceptions of cannabis edibles, packaging with flavor imagery showed greater appeal, safety & healthiness, outdoor & medical imagery conveyed healthiness, animal imagery had greater appeal to children & product descriptors like all natural, organic or handcrafted were associated with less appeal
The Impact of Product Packaging on Perceptions of Cannabis Edibles: Results from Two Randomized Experiments
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2670605

🚗 Driving 🚗

In Chile after the 2014 strengthening of alcohol-impaired driving laws, driving under the influence of alcohol declined substantially while driving under the influence of cannabis increased modestly, suggesting potential substitution
Alcohol- and cannabis-impaired driving in Chile, 2012–2022: trends in the context of alcohol policy changes and substitution theory
https://www.tandfonline.com/doi/abs/10.1080/15389588.2026.2664669

🚓 The War on Drugs 🚓

In Mexico, 2 more sitting governors are being investigated by the US for connections to cartels
https://www.latimes.com/world-nation/story/2026-06-03/u-s-is-investigating-two-more-mexican-governors-for-connections-to-cartels
This was an excellent deep dive on the situation that gives both sides of the story. I have to say that I was suspicious when one of the accused governors said that he was so honest “I practically sweat holy water” (as Gertrude said, “The lady doth protest too much, methinks”). Both governors are within President Sheinbaum’s party & the accusations, as well as more potential charges against allies, change her political calculus for elections next year. But she is circling the wagons & declaring the charges to be politically motivated US attacks against a leftist administration.

In Guatemala, the president denied reports that there is a deal with the US on anti-drug trafficking strikes
https://apnews.com/article/guatemala-us-drug-trafficking-agreement-trump-arevalo-cba80c7fddba03d69a35a3670d29498d

In Barcelona, a cannabis smuggling organization was dismantled with 5 arrested & 1.7 tons seized
https://cannabislaw.report/an-organization-that-smuggled-marijuana-from-the-port-of-barcelona-has-been-dismantled-and-1-7-tons-have-been-seized/
But meanwhile, the police patrol boats along the coastline are so thinly spread that narco gangs wave for the cameras in marinas
https://cannabislaw.report/spain-narco-gangs-wave-cheekily-at-cameras-in-marinas-as-spains-guardia-civil-has-one-functioning-boat-to-police-200km-of-costa-del-sol-coastline/

In Mexico, a list of officials accused of working with organized crime
https://insightcrime.org/news/most-notorious-mexico-officials-accused-organized-crime/

In New Zealand, a mob boss’s daughter sentenced for dealing cannabis
https://cannabislaw.report/nz-operation-highwater-daughter-of-late-gang-boss-steven-taiatini-sentenced-for-dealing-cannabis/

In California, a man alleged he was forced to work for 2 years without pay at a cannabis farm
https://cannabislaw.report/media-report-forced-labor-alleged-at-illegal-mendocino-county-marijuana-farm-for-2-years/

In South Africa, a drug lab bust arrested 11 people, including 4 Mexican nationals
https://www.sanews.gov.za/south-africa/11-suspects-arrested-major-north-west-drug-lab-bust

In Greece, a mountain cannabis farm using solar power was busted for growing 1400+ plants
https://cannabislaw.report/in-the-land-of-the-gods-greece-mountain-cannabis-farm-using-solar-power-busted/

In Israel, a cannabis nursery was raided with hundreds of plants seized & 2 suspects arrested
https://cannabislaw.report/israel-police-arrest-two-in-raid-on-rehovot-cannabis-nursery-seize-hundreds-of-plants/

In the Netherlands, a man faces 9 years in prison for growing cannabis in a rental house
https://cannabislaw.report/dutch-citizen-faces-9-years-in-prison-for-growing-cannabis-in-a-denpasar-rental-house/

In Nigeria, a 63-year-old grandma from China was arrested with 31 kg of cannabis
https://cannabislaw.report/ndlea-arrests-63-year-old-at-logos-airport-for-bringing-in-31-kilos-of-canadian-loud/

In Oman, a passenger arrested after trying to smuggle 6 kg of cannabis
https://cannabislaw.report/oman-arrests-passenger-for-trying-to-smuggle-more-than-6kg-of-marijuana-through-muscat-airport/

In Australia, 5 kg of cannabis seized during a traffic stop
https://cannabislaw.report/outlaw-country-police-allege-27000-cannabis-haul-found-along-the-road-to-gundagai/

In Egypt, a hotel employee & guest who served a cannabis-infused cake to an unknowing tourist were sentenced to 3 years in prison with hard labor
https://cannabislaw.report/egypt-three-years-in-prison-for-egyptian-hotel-employee-and-brazilian-guest-following-hashish-cake-prank/

WoD Research

In Lebanon & Syria, a report on the changing landscape of drug trafficking
The Changing Landscape of Drug Trafficking Within the Emerging Political Context in Lebanon and Syria
https://www.aub.edu.lb/ifi/Documents/The-Changing-Landscape-of-Drug-Trafficking-Lebanon-Syria.pdf

On the use of drones by the Sinaloa cartel
The Drones of CDS
https://digitalcommons.unomaha.edu/cgi/viewcontent.cgi?article=1154&context=ncitereportsresearch

For cartel recruitment of juveniles, a thesis project on the political economy of violence
Big Trucks and Plated Guns: A Political Economy of Violence and Juvenile Mexican Cartel Recruitment
https://www.proquest.com/openview/22a94f88f240f0c24936e67ab37a9e57/1

🛡️ Harm Reduction News 🛡️

When a teen died after asking ChatGPT for drug mixing advice, his parents sued OpenAI
https://www.cbsnews.com/news/open-ai-chatgpt-drug-overdose-lawsuit/
In general, do not mix kratom with benzodiazepines. Two downers is too much downing

Harm Reduction Research

In East Africa, this thesis project analyzed the effects of drug policy on overdose mortality
Drugs, Development, and the State: Understanding Addiction Policy Variation in East Africa
https://www.proquest.com/openview/60d6d4f05702fefc390770908c7b9e9e/1
“My key findings are that while harm reduction coverage is associated with lower overdose mortality in the aggregate, this relationship is significantly weakened and reversed as corruption increases. MAT [medication-assisted treatment] is particularly vulnerable to corruption. Higher-level regime corruption exhibited the strongest influence on overdose rates.”

🍄 Psychoactives, Psychedelics & Plant Medicines 🍄

For women’s drug use in Latin America, a review of the last 24 years of research
Twenty-Four Years of Research on Women’s Drug Use in Latin America: A Scoping Review (2000-2024)
https://repositorio.cedes.org/handle/123456789/4833

Psychedelics & MDMA

For difficulties in psychedelic integration, interviews on therapist on themes of integration strategies
Symptom-Specific Nuances in Psychedelic Integration: A Qualitative Study of Insights from Therapists Supporting Extended Difficulties in Naturalistic Settings
https://assets-eu.researchsquare.com/files/rs-9448195/v1/6c20a261-caa8-4056-b82a-e026c0551576.pdf

For plant medicines in Indigenous mental health care, a review for respectful integration
Plant Medicines in Indigenous Mental Health Care: Traditional Knowledge, Contemporary Evidence, Ethical Principles, and Pathways for Respectful Integration
https://lonestarhealing.org/papers/plant-medicines-indigenous-mental-health.pdf

For US psychedelic facilitation training, an analysis of the 13 organizations
A landscape analysis of psychedelic facilitation training in the US
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0350037

For people with opioid dependence, a collective case study on the use of ibogaine
Exploring the Use of Ibogaine in Opioid Recovery: Insights from Lived Experience
https://www.tandfonline.com/doi/pdf/10.1080/02791072.2026.2673843

For treatment-resistant major depression, psilocybin caused meaningful antidepressant effects for up to 12 months
Long-Term Efficacy of Psilocybin with Adjunct Psychotherapy in Treatment-Resistant Major Depression (EPIsoDE): 6- and 12-Month Naturalistic Follow-Up of a Phase 2b Trial
https://karger.com/pps/article-pdf/doi/10.1159/000552272/4541533/000552272.pdf

For people who took 5-MeO-DMT, voice journal analysis of their speech markers “revealed increased cognitive language, decreased social words, and altered voice quality (increased jitter/shimmer) [and] baseline speech patterns predicted psychedelic preparedness, emotional breakthrough, and post-experience well-being”
Speech markers of psychological change following a psychedelic 5-MeO-DMT retreat
https://journals.sagepub.com/doi/pdf/10.1177/02698811261443690

For anxiety & psilocybin, a meta-analysis of 25 studies found heterogeneous results that show promise for anxiety reduction
Effect of psilocybin-assisted psychotherapy on anxiety symptoms: A systematic review and meta-analysis
https://www.akjournals.com/view/journals/2054/aop/article-10.1556-2054.2026.00507/article-10.1556-2054.2026.00507.xml

For psychedelics & mania, a meta-analysis of 23 studies of euphoria, hypomania & mania
Psychedelic-induced hypomania and mania: a systematic review and meta-analysis
https://www.nature.com/articles/s41380-026-03657-6

For the classic psychedelics, a review of how they move through the human body
A systematic review of the pharmacokinetics of classical serotonergic psychedelic compounds in healthy adult subjects
https://journals.sagepub.com/doi/full/10.1177/02698811261453938

For psilocybin, a case report of somebody passing out due to low blood pressure
Psilocybin-induced neurocardiogenic syncope: a case report
https://link.springer.com/article/10.1007/s00213-026-07079-8

Ketamine

For substance use disorders, a meta-analysis of 15 trials found ketamine significantly increased abstinence rates
Ketamine for substance use disorders: A systematic review and meta-analysis
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1835709/abstract

In people treatment resistant depression & suicidal ideation, the majority had improvements after ketamine IV treatments
Early suicidal ideation change and suicidality-associated emergency department utilization after ketamine or esketamine treatment in treatment-resistant depression
https://journals.sagepub.com/doi/pdf/10.1177/20451253261450747

For major depressive episodes, a meta-analysis of 26 trials found a single ketamine injection significantly reduced depressive symptoms
Meta-Analysis: Ketamine Injections Rapidly Reduce Major Depressive Episode Symptoms
https://jamanetwork.com/journals/jama/fullarticle/2849868

For people undergoing ketamine detoxification, a case series found that all reported urological symptoms
Management of ketamine use disorder and associated urological complications: an inpatient detox case series
https://www.tandfonline.com/doi/full/10.1080/14659891.2026.2679106

For PTSD, a case study of using ketamine-assisted psychotherapy
Ketamine-assisted psychotherapy for treatment of an Asian American patient with post-traumatic stress disorder (PTSD): a case study
https://www.sciencedirect.com/science/article/pii/S2773021226000258

For ketamine, both neurotoxic & neuroprotective effects were reviewed across 55 animal & 21 human studies
Structural Neurotoxic and Neuroprotective Effects of Ketamine and Esketamine in Preclinical and Human Studies: A Systematic Review
https://assets-eu.researchsquare.com/files/rs-9827580/v1/a432eff6-09a3-48d7-9d8b-f535ef0549ee.pdf

For depression in cancer patients, a review of ketamine’s efficacy & safety
The Use of Ketamine for Depression in Cancer Patients: A Systematic Review of Efficacy, Safety, and Clinical Applications
https://www.tandfonline.com/doi/full/10.1080/15360288.2026.2679720

🍃 The Plant & its Products 🍃

🌱 Growing 🌱

For fertilizing hemp, a case study from Poland on the energy efficiency of different types of fertilization
Energy efficiency of industrial hemp biomass production under recycled organic and mineral fertilization: A case study from Poland
https://www.sciencedirect.com/science/article/abs/pii/S116103012600198X

For weed control & industrial hemp, an analysis of 19 different treatments & their effects on growth
Effects of Weed Control Strategies on Fiber Yield and Yield Components in Industrial Hemp (Cannabis sativa L.)
https://link.springer.com/article/10.1007/s10343-026-01352-8

For cannabis pests in Pennsylvania, a thesis project found that they were more abundant but less diverse than natural enemy communities & looked at the possibility of using biological control methods
Understanding the Potential for Biological Control and Pest Management in Industrial Hemp Cropping Systems
https://etda.libraries.psu.edu/catalog/20035jlj5655

For hemp & borer pests, a thesis project assessing their resistance
Assessing Host Plant Resistance of Hemp (Cannabis sativa L.) to Borer Pests
https://agroecology.wisc.edu/wp-content/uploads/sites/75/2026/05/Final-Agroecology-MS-Thesis.pdf

In 3 Chinese hemp varieties, an analysis of their cannabinoid & terpenoid levels
Cannabinoids and Terpenoids in Hemp Inflorescence and Leaves of Three Varieties in Yunnan China
https://pubmed.ncbi.nlm.nih.gov/42185735/

For the AHL gene family, a genome-wide analysis of on its effects on cannabis flowering
Genome-wide identification of the AHL gene family in hemp and the role of CsAHL15 in delayed flowering
https://www.sciencedirect.com/science/article/pii/S0926669026009192

⚙️ Extracting, Analyzing & Formulating ⚙️

On creating a set of rules for identifying cannabinoids with mass spectrometry
A MassQL-Based Framework for Rule-Guided MS/MS Class-Level Retrieval and Analog Discovery of Cannabinoids
https://pubmed.ncbi.nlm.nih.gov/42175698/

For finding toxic elements in cannabis, on using inductively coupled plasma optical emission spectroscopy (ICP OES)
Determination of potentially toxic elements (Arsenic, Cadmium, Mercury, and Lead) in Hemp (Cannabis sativa L.) from using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP OES)
https://academic.oup.com/jaoac/advance-article-abstract/doi/10.1093/jaoacint/qsag044/8698150

On improving CBD solubility by creating micro- & nanoparticles via the electrospray method
Development and characterization of electrosprayed cannabidiol micro/nanoparticles with improved solubility and drug release
https://www.sciencedirect.com/science/article/abs/pii/S1773224726005071

🍞 Food & Nutrition 🍞

For strawberries, on applying a CBD-based edible coating to protect from bacteria
Evaluation of Phytocannabinoid-Based Edible Coating as a Natural Antimicrobial Solution to Improve Strawberry Quality and Shelf life
https://www.cetjournal.it/cet/26/124/050.pdf

When feeding dogs hempseed byproducts, they had an increase in the species richness of their microbiome
Longitudinal Assessment of the Canine Fecal Microbiota in Response to Dietary Hempseed By-Product and Oil: A 90-Day Nutritional Intervention Study
https://www.mdpi.com/2306-7381/13/6/534

For feeding hemp byproducts to animals, an analysis of the nutritional components
Valorization of By-Products Resulting from Hemp Processing in Order to Formulate Feed for the Livestock Sector
https://openurl.ebsco.com/EPDB%3Agcd%3A2%3A1700370/detailv2?sid=ebsco%3Aplink%3Acrawler-gcd&id=ebsco%3Agcd%3A193696758&crl=c&jrnl=15842665&link_origin=none

🏗️ Industrial Uses & Fiber 🏗️

For hemp biodiesel, on optimizing for a compression ignition engine
Hybrid Response Surface Methodology--Extreme Gradient Boosting Optimization of a Hemp Biodiesel--Diesel Fueled Compression Ignition Engine.
https://openurl.ebsco.com/EPDB%3Agcd%3A13%3A10866381/detailv2?sid=ebsco%3Aplink%3Acrawler-gcd&id=ebsco%3Agcd%3A193842463&crl=f&jrnl=20885334&link_origin=none

On creating supercapacitors electrodes with manganese dioxide & hemp-derived activated carbon
Hydrothermal Synthesis of MnO2 and Hemp-Derived Activated Carbon Composites for Tailored Electrochemical Performance
https://advanced.onlinelibrary.wiley.com/doi/abs/10.1002/adem.70924

On creating an epoxy composite reinforced with hemp fiber coir & eggshells for good biodegradability
Sustainable Hybrid Epoxy Composites Reinforced with Hemp Fiber Coir and Nano Egg Shell Particle for Biodegradability Evaluation
https://www.epj-conferences.org/articles/epjconf/pdf/2026/26/epjconf_iemphys-26_01008.pdf

For hemp concrete walls, on developing a model of hot air moisture flow for lessening temperature fluctuations & moisture variations
Influence of Insulation Placement on the Hygrothermal Performance of Hemp Concrete Walls
https://www.epj-conferences.org/articles/epjconf/pdf/2026/27/epjconf_amt2026_01015.pdf

On the potential of using hemp for insulation & board materials
Innovative Hemp-Based Building Materials: Technical Properties and Ecological Potential
https://ndibv-building.com.ua/index.php/Building/article/view/589

For mortars using hemp & starch, an analysis of their mechanical, thermal & durability properties
Mechanical, Thermal, and Durability Performance of Bio-Based Mortars with Hemp and Starch
https://hal.science/hal-05633020/

For hemp-lime composites, on the effects of compaction & water-to-binder ratios on thermal conductivity & compressive strength
Effect of Technological Variables on Thermal Conductivity and Compressive Strength of Hemp–Lime Composites
https://www.mdpi.com/2673-4109/7/2/33

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

🏥 Public Health & Bioassays 🏥

Among indigenous populations, a review of 40 studies on the prevalence of cannabis use, with Australia having the highest levels
Prevalence of Cannabis Use Among Indigenous Populations – A Systematic Review
https://www.tandfonline.com/doi/pdf/10.1080/10826084.2026.2670614

For cannabinoids seized in northern Italy, a profile of the semi-synthetic cannabinoids found
Comprehensive Profiling of Phytocannabinoids and Semisynthetic Cannabinoids in Seized Materials from Northern Italy
https://pubs.acs.org/doi/full/10.1021/acsomega.6c00941

Among US healthcare professionals, a survey about cannabis found their highest self-reported knowledge to be for the risks of cannabis, followed by therapeutic indications & mechanisms of action, but their objective knowledge check scores were generally low
Knowledge, attitudes, and concerns about medical cannabis among U.S. healthcare professionals
https://link.springer.com/article/10.1186/s42238-026-00450-8

For cannabis nurses, interviews on their themes for integration in the mainstream healthcare
Lessons learned from an academic and clinical partnership to address barriers and facilitators of cannabis education and practice
https://www.psychiatricnursing.org/article/S0883-9417(26)00096-8/abstract

In Washington state, a greater density of cannabis stores was associated with greater parental cannabis use frequency, acceptability of use & lower perceived addictiveness
Local availability of cannabis retail outlets on parents’ cannabis use, acceptability, and perceived addictiveness: A longitudinal study in Washington State
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0348182

In Bosnia & Herzegovina, a survey found the majority felt positively about the therapeutic effects of cannabis
Public Opinion Survey on Cannabis Legalization
https://hrcak.srce.hr/file/501568

For cannabis & cigarette consumption, a review of their impact
Investigating the Impact of Cannabis and Cigarette Consumption: A Systematic Review
https://www.researchgate.net/publication/405221011_Investigating_The_Impact_Of_Cannabis_And_Cigarette_Consumption_A_Systematic_Review

🧒 Adolescents & Young Adults 🧒

In adolescents with cannabis use disorder (CUD) & a co-occurring internalizing and/or externalizing disorder, the psychiatric comorbidity was associated with a doubled likelihood of repeating a grade or dropping out of school while CUD was not a predictor of school impairment
Adolescent with cannabis use disorder and other mental health disorders: does dual disorder worsen school impairment?
https://link.springer.com/article/10.1186/s42238-026-00449-1

In transgender & gender diverse youth, greater gender minority stress was linked to greater use of alcohol & the co-use of alcohol & cannabis
Characterizing Alcohol and Cannabis Co-use and Related Harms Among Transgender and Gender Diverse Youth
https://link.springer.com/article/10.1007/s11121-026-01931-1

For Queer young adults during the 2024 presidential election, discrimination had associations with alcohol & cannabis use
Psychological pathways linking discrimination to alcohol and marijuana use among LGB young adults during the 2024 presidential election
https://pubmed.ncbi.nlm.nih.gov/42186182/

For young adults, a trial of an app for promoting lower-risk cannabis use appeared “promising, acceptable, and scalable”
Acceptability, Feasibility, and Outcome Responsiveness of the Joint Effort Mobile App for Promoting Lower-Risk Cannabis Use Among Young Adults: Pilot Randomized Controlled Trial
https://mhealth.jmir.org/2026/1/e71957

In young adults co-using alcohol & cannabis, they were less likely to engage in protective behavioral strategies around their alcohol use
Are alcohol protective behavioral strategies associated with simultaneous use of alcohol and cannabis among young adults?
https://www.tandfonline.com/doi/abs/10.1080/14659891.2026.2678167

🧠 The Brain & Neurological Disorders 🧠

On GABA (the brain’s most common inhibitory neurotransmitter), on its potential control by endocannabinoid signaling
The endogenous cannabinoid system gates plasticity of tonic GABA inhibition
https://physoc.onlinelibrary.wiley.com/doi/pdf/10.1113/JP289183

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

For the co-use of cannabis & nicotine, a double-blind trial found that recent cannabis use was associated with a greater aversive response to an IV dose of nicotine
Recent Cannabis Exposure and Acute Nicotine Effects: Insights from Randomized, Double-Blind, Placebo-Controlled Intravenous Nicotine Studies
https://www.researchgate.net/publication/405404213_Recent_Cannabis_Exposure_and_Acute_Nicotine_Effects_Insights_from_Randomized_Double-Blind_Placebo-Controlled_Intravenous_Nicotine_Studies

🧬 Reproduction & Hormones 🧬

In a small sample of pregnant cannabis users, cannabis use in early pregnancy was not significantly associated with preterm birth or small for gestational age
Cannabis use, preterm birth, and small for gestational age: findings from the national birth defects prevention study
https://www.nature.com/articles/s41372-026-02729-3

🦠 The Immune System & Microbial 🦠

In people with & without HIV in a tobacco smoking cessation trial, they had similar levels of cannabis use & pain-related sleep issues
Exploring Tobacco, Cannabis, and Pain-Related Sleep Disturbance Among People With and Without HIV Enrolled in a Tobacco Smoking Cessation Trial
https://www.sciencedirect.com/science/article/abs/pii/S0376871626002012

For protecting against COVID-19, on a combination of cannabinoids & Artemisia annua (sweet wormwood)
Selected Cannabinoids, Cannabimimetic Agents and Artemisia Combinations as Theoretical Adjunct Strategies Against COVID-19
https://www.mdpi.com/1424-8247/19/6/869

In a microglia (guardian immune cells of the brain) model of HIV, this thesis project found that CBD & THC significantly reduced HIV replication as well as modulating inflammation & immunomodulatory signaling
Exploring the Effect of CBD/THC on a Primary Microglia-like Cell Model During HIV-1 Infection
https://www.proquest.com/openview/4f14db0609a45fd2c51fc27a4d742315/1?pq-origsite=gscholar&cbl=18750&diss=y

🦴 Pain, Musculoskeletal, Inflammation & Surgeries 🦴

In older adults with chronic pain, those who intended to start medical cannabis reported more severe short-term pain, greater pain interference & lower subjective sleep quality
Baseline factors associated with intention to initiate medical cannabis among older adults with chronic pain in a prospective cohort
https://karger.com/mca/article-pdf/doi/10.1159/000552277/4542436/000552277.pdf

In people with arthritis, a survey found that cannabis users reported higher pain & stress as well as worse self-rated health
Cannabis use in arthritis: impact on health-related quality of life
https://karger.com/mca/article-pdf/doi/10.1159/000552591/4542073/000552591.pdf

🍽️ The Guts, Nutrition & the Microbiome 🍽️

In mice with no gut microbiome, on the differences in the levels of their endocannabinoid machinery across their organs
Intestinal colonization of germ-free mice with indole-producing E. coli modulates the central and peripheral endocannabinoidome
https://www.sciencedirect.com/science/article/pii/S0022227526000969

💧 The Genitourinary System 💧

In a guinea pig model of bladder pain, activating both the CB1 & CB2 receptor abolished the hypersensitivity to pain
Combined peripheral cannabinoid CB1 and CB2 receptor activation abolishes cystitis-induced bladder hyperalgesia
https://www.sciencedirect.com/science/article/pii/S1566070226000664

🖐️ The Skin & Topicals 🖐️

For transdermal delivery of CBD for diseases of skin inflammation, on creating an amorphous solid on a hydrogel platform
Amorphous Solid Dispersion Hydrogel Platform for Transdermal Delivery of Cannabidiol with Therapeutic Potential for Dermatitis
https://www.mdpi.com/1999-4923/18/6/666

🎗️ Cancer & Chemotherapy 🎗️

In veterans using anticancer drugs, over one-third acknowledged the use of cannabis products within the previous 3 months
Cannabis Use by Veterans and Potential Interactions With Antineoplastic Agents: Analysis and Literature Review
https://cdn.mdedge.com/files/s3fs-public/issues/articles/0526FED%20AVAHO%20Cannabis.pdf

In breast cancer cells resistant to tamoxifen, CBD significantly enhanced cell death & apoptosis (programmed cellular suicide)
Cannabidiol enhances tamoxifen efficacy via CREB-mediated suppression of ERα signaling in ER-positive breast cancer cells
https://link.springer.com/article/10.1186/s13578-026-01588-x

For treating prostate cancer with CBD & its major metabolite, on developing liposomal methods for better bioavailability
Liposomal CBD and 7-OH-CBD for Prostate Cancer Treatment: Physicochemical Characterization and Efficacy Across Multiple Lipid Compositions
https://www.ba.ic.cnr.it/nanomedicine2026/wp-content/uploads/2026/04/Commito_Francesca_NM26.pdf

💊 Synthetic Cannabinoids & Hemp-Derived Cannabinoids 💊

Characterizing the synthetic cannabinoid MDMB-5′Br-PINACA & its metabolites
Physicochemical Characterization and Metabolites Identification of the Synthetic Cannabinoid MDMB-5′Br-PINACA Using In Silico and In Vitro Approaches
https://pubs.acs.org/doi/full/10.1021/acs.chemrestox.6c00107

🔬 Biochemical Discoveries & Research Tools 🔬

On creating drugs that are activated by fluorescent light to inhibit the enzyme MAGL (which breaks down the endocannabinoid 2-AG) for anti-inflammatory & liver protecting effects
A Rationally Engineered MAGL-Activatable Fluorogenic Probe Enables Efficient Discovery of Anti-Inflammatory and Hepatoprotective Agents
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.6c01300

Thanks.
- lex

PS: For one of the greatest songwriters of the last century, here is the first Mose Allison album of only vocals, ‘Mose Allison Sings’ (1963). I’ve been excited to tell you about Allison ever since I discovered him & he’s the reason that I’ve been listening religiously to my Spotify Discover Weekly for the a number of years now. Because when he showed up on there 3 years ago, I listened to this album on loop for 2 months & I still play it often enough that my kids know exactly what’s coming. Honestly, I don’t know how to describe what makes him so magical. He famously suffered from a categorization problem because even though he might sound like boogie-woogie piano mixed with blues & jazz, he wrote some of the most fun, poetic, ironic & sometimes dark songs. Van Morrison called him “the jazz version of Lenny Bruce.”
Born on his grandfather’s farm in Tippo, Mississippi in 1927, Allison was playing piano by ear by the age of 5, wrote his first song at 13 & was figuring out the boogie-woogie tunes he heard on the local jukebox. He led bands during his university years & there met his wife of 65 years. They moved to New York in 1956 where he began recording with Prestige Records, but mostly instrumental pieces of Mississippi Delta blues & jazz standards released to unanimous critical acclaim. He released albums for Columbia before meeting the great Nesuhi Ertegun of Atlantic Records, a record producer who he prized for really getting what he was trying to do. Allison recorded with them for over a decade with a string of successes & by the 70s was playing more & more in Europe & Japan. His last album was 2010’s ‘The Way of the World’ & it went to #1 on the CMJ jazz chart. He passed away 6 years later in his home in Hilton Head, South Carolina. And for any Pixies fans out there, their song ‘Allison’ is a tribute to our beloved Mose.

This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.
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MS, lung harms & CBD for chronic pain in OUD + parrots, bats & snakes oh my!

Lex Pelger WhiteWhaleCreations — Mon, 01 Jun 2026 11:52:00 GMT

Cannabinoids & The People,
or; Drugs & Drug Wars

🌟 This Week 🌟

(#hashtags for jumping to articles by searching for them with your browser)

Cannabinoids for MS!
CBD for the chronic pain of people with opioid use disorder
Lungs: 13 studies on worsened respiratory symptoms
Delightful new animal data: endocannabinoids in parrots, bats & snakes! (#animals)
Preclinical: CBD for muscle atrophy
Growing: CBD protected hemp from corn earworms
Ketamine: Norway reimburses IV ketamine for depression (cue the jokes in my group chat)

[numbers for C&P#189: ~6k words, ~16 minutes reading time, 130 papers]

📌 Editor’s note 📌:
I had less time this week for the processing of science because I had to switch video editing software. After Kapwing choked on my 20-minute ‘Funniest Cannabis Smuggling Story of All Time’, I finally chose to go with Descript so I’ll be future-proofed for longer videos such as the podcasts I’d like to get back to making as these kids grow up. I used Descript for most of the videos I released below this week & while I’m still working on my colors & fonts, I’m excited for the new potential for making these videos better & more engaging. If you want to follow along, the main outlet I want to build up is my YouTube channel @CannabinoidsAndThePeople.

Hello everyone,
Welcome to the 189^th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news + the War on Drugs, harm reduction & other psychoactives. Support this work with a paid subscription or by buying me a coffee.

🤝 Sponsor 🤝:
The Cannabis & Health Research Initiative

Want to help expand the knowledge of medical cannabis use in the real world & get paid 100 bucks to do so?

Follow along on Instagram to keep on learning or sign up for the monthly CHRI email (curated by me) to get just the best of clinical research & new reviews twice a month.

🎥 Lex’s new work 🎤

@CannabinoidsAndThePeople on YouTube, TikTok & LinkedIn
Canna-edu videos sponsored by the National Cannabis Study (join & get paid $100 to talk about your use of our favorite plant)

Vaping vs Smoking Cannabis: Which Is Actually Safer? (the Science)
The Funniest Cannabis Smuggling Story of All Time (20+ minutes, but I think it’s worth it)

Canna-science Videos for CV Sciences on YT @CVSciencesInc & on TT @pluscbd
For 30% off their CBD, THC & PEA products, at pluscbdoil.com use the coupon code ‘LEX’

@LexPelgerAndHisBooks on TikTok, YouTube & Instagram:

And as always, at the bottom is the album of the week: a godfather of the Cuban drums

💖 Ways to support this work 💖

- Venmo: @Lex-Pelger

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📣 A request to spread the word 📣

This newsletter only spreads by word of mouth, so please share to friends & colleagues.

🍃 BEST OF CANNABINOID SCIENCE 🍃

(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)

⚕️ Clinical ⚕️

In people with multiple sclerosis using cannabinoids, a meta-analysis of 20 studies found significant reductions in pain intensity, spasticity severity & disability
Efficacy of Sativex® on pain, spasticity, and disability in patients with multiple sclerosis: A systematic review and meta-analysis
https://www.sciencedirect.com/science/article/pii/S1043661826001659

In people with chronic pain using methadone for their opioid use disorder, CBD helped with pain at lower doses but worsened pain sensitivity at higher doses (1200 mg)
An opioid-withholding human laboratory paradigm during opioid agonist treatment for opioid use disorder and chronic pain: Phase- and dose-dependent effects of cannabidiol
https://www.nature.com/articles/s41386-026-02443-w

For CBD & drug-resistant epilepsy, a meta-analysis of 7 trials found it caused clinically meaningful reductions in seizures with an acceptable safety profile
Adjunctive Cannabidiol for Drug-Resistant Epilepsy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
https://www.tandfonline.com/doi/pdf/10.2147/TCRM.S601774
And in pediatric epilepsy, CBD reduced epilepsy severity, seizures, medication use, emergency visits & hospitalizations
Effectiveness and tolerability of cannabidiol in paediatric epilepsy: a one-year multisite prospective study
https://www.sciencedirect.com/science/article/pii/S1525505026002167

For chronic pain due to fibromyalgia or arthritis, 12 weeks of different combinations of cannabinoids (including CBD, THC, CBDA, CBG & CBC) had beneficial effects
Assessing the Efficacy of Cannabinoid Compositions for Treating 3 Classes of Chronic Pain: A Real-World Evidence Study
https://www.sciencedirect.com/science/article/abs/pii/S0149291826001360

In people with Parkinson’s disease using cannabinoids, a meta-analysis of 11 trials found they had no significant benefit
Therapeutic effects of cannabinoids on Parkinson’s disease: an updated systematic review and meta-analysis of randomized controlled trials
https://pubmed.ncbi.nlm.nih.gov/42138778/
Sometimes a piece of research just leaves you scratching your head. I don’t feel like diving into the guts of this one. Some of the most overwhelming anecdotal evidence you hear about cannabinoids is from people with Parkinson’s disease & roughly every month I see another clinical study backing that up.

In people with first-episode psychosis, cannabis use was not associated with significant differences in clinical outcomes or recovery but was associated with more intensive antipsychotic treatment
Cannabis Use and Clinical Outcomes in First Episode Psychosis: Results From a 2-Year Follow-Up Study
https://pubmed.ncbi.nlm.nih.gov/42141813/
And in first-episode psychosis, cannabis use at baseline predicted lower adherence to treatment at 3 months
Medication adherence, cannabis use, and depressive symptoms in first-episode psychosis: longitudinal study
https://www.tandfonline.com/doi/abs/10.1080/09638237.2026.2672339

For smoked cannabis & gender differences, researchers found “a lack of consistent sex differences in the acute effects of smoked cannabis across a range of potencies”
Lack of Consistent Sex Differences in the Acute Effects of Smoked Cannabis: A Potency-Ranging, Controlled Administration, Human Laboratory Experiment
https://assets-eu.researchsquare.com/files/rs-9441659/v1/4eaf3e10-ad20-4c9f-8b77-7d6128c4bfb8.pdf
This is a study going against the grain, because most find gendered differences in the acute effects of cannabis.

For cannabis use among couples, interviews with South Asian people on the effects on their relationship
And they lived happily ever after? Experiences of couples affected by marijuana use explored using Rogers’ tentative law of interpersonal relationships
https://www.tandfonline.com/doi/abs/10.1080/14779757.2026.2670363

For cannabis edibles, the fast-acting edibles worked faster than the standard edibles though both produced several hours of subjective impairment
Behavioral and Self-Report Cognitive Impairment Differences between Fast-Acting, Standard, and Placebo Cannabis Edibles
https://assets-eu.researchsquare.com/files/rs-9621757/v1/0f842506-64c0-4c7f-ac26-a7b89e9b5837.pdf

In people using transcranial magnetic stimulation for their depression, cannabis use did not alter their clinical outcomes
Puff, Puff, or Pass? Use of Cannabis on TMS Outcomes for Major Depressive Disorder
https://www.tmsjournal.org/article/S3050-5291(26)00069-3/pdf

When giving CBD & THC to parrots, food did not increase the bioavailability but it did slow down the absorption time & extend the half-life (#animals)
Food Effects on the Pharmacokinetics of Orally Administered Cannabinoids in Hispaniolan Amazon Parrots (Amazonia ventralis)
https://bioone.org/journals/journal-of-avian-medicine-and-surgery/volume-40/issue-2/AVIANMS-D-25-00008/Food-Effects-on-the-Pharmacokinetics-of-Orally-Administered-Cannabinoids-in/10.1647/AVIANMS-D-25-00008.full
Delighted to add this new piece of research to my small but growing collection of parrot/cannabinoid data…

In bats, a brief mention of how endocannabinoids may relate to their flying
High Relevance of Fatty Acid Oxidation in a Migrating Mammal, the Nathusius’ Pipistrelle (Pipistrellus nathusii)
https://faseb.onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.202600860R
And truly delighted to add my very first endocannabinoid paper involving flying mammals…

In red-sided garter snakes, as they began their migration to feeding grounds, their levels of the endocannabinoid 2-AG dropped in their hippocampus (a memory center of the brain) while blocking the CB1 receptor reduced male courtship behavior
The endocannabinoid 2-arachidonoylglycerol mediates seasonal life-history transitions in a wild reptile
https://cob.silverchair-cdn.com/cob/content_public/journal/jeb/jam/10.1242_jeb.251845/1/jeb251845.pdf
And delighted to have my 2^nd ever snake data, after the first on the Burmese python…

⚠️ Lung Harms ⚠️

(Many of these come from the American Thoracic Society Conference 2026 meeting just held in Florida. Look for the URL ‘academic.oup.com/ajrccm’)

In young adults who smoke or vape cannabis, vaping-only was not linked to increased respiratory symptoms but smoking & dual-use was
Cannabis vaping, smoking, and dual use and the onset of respiratory symptoms among US young adults
https://www.sciencedirect.com/science/article/abs/pii/S0749379726001649

In adults with asthma, those inhaling cannabis products had higher odds of asthma attacks
Smoked and Vaped Marijuana Is Associated With Higher Risk of Asthma Attacks
https://academic.oup.com/ajrccm/article/212/Supplement_1/aamag162.6533/8686991

In people with asthma, cannabis use was associated with increased morbidity & mortality
Impact of Marijuana Use on Asthma Exacerbation Outcomes: Insights From a Multi-Institutional Real World Dataset
https://academic.oup.com/ajrccm/article/212/Supplement_1/aamag162.6488/8686888

In a lung fungal infection, a case report linked it to cannabis use in a young adult (when normally it’s found in people with immune system problems)
Pulmonary Mucormycosis in an Immunocompetent Young Adult With Heavy Cannabis History
https://academic.oup.com/ajrccm/article/212/Supplement_1/aamag162.4194/8683948

In ventricular fibrillation (the lower heart chambers contracting rapidly in an uncoordinated manner), a case report of a man having a heart attack right after smoking cannabis
Refractory Ventricular Fibrillation and Multiorgan Failure Following Cannabis Exposure: A Critical Care Management Challenge
https://academic.oup.com/ajrccm/article/212/Supplement_1/aamag162.6505/8686686

For a rare lung pneumonia, a case report linked it to daily cannabis smoking
A Rare Case of Chronic Eosinophilic Pneumonia Due to Marijuana Inhalation
https://academic.oup.com/ajrccm/article/212/Supplement_1/aamag162.2308/8681643

In someone bleeding in their lung alveoli, the researchers on this case report deemed inhalant injury (of cannabis) to be the most likely cause
Recurrent Diffuse Alveolar Hemorrhage Associated With Smoking Cannabis
https://academic.oup.com/ajrccm/article/212/Supplement_1/aamag162.105/8679810

In a young adult with inhalational lung injury, on the link to smoking butane hash oil
Butane Hash Oil-Induced Inhalational Lung Injury in a Young Adult: The Diagnostic Challenges
https://academic.oup.com/ajrccm/article/212/Supplement_1/aamag162.3038/8682569

In someone with cannabinoid hyperemesis, on the vomiting leading to a hole in the esophagus & air in the chest cavity
Esophageal Perforation and Pneumomediastinum Secondary to Cannabinoid Hyperemesis Syndrome
https://academic.oup.com/ajrccm/article/212/Supplement_1/aamag162.3176/8682762

In someone with cannabinoid hyperemesis syndrome, they developed air in their chest cavity
A Chronic Habit With an Acute Complication: Spontaneous Pneumomediastinum Due to Cannabinoid Hyperemesis Syndrome
https://academic.oup.com/ajrccm/article/212/Supplement_1/aamag162.6521/8686879

In young adult vaping, both cannabis & nicotine were associated with respiratory symptoms, with dual use carrying more risk
Association of Nicotine and Cannabis Vaping and Respiratory Symptoms in U.S. Young Adults: The American Lung Association Lung Health Cohort Study
https://academic.oup.com/ajrccm/article/212/Supplement_1/aamag162.6514/8686517

In people who co-use tobacco & cannabis, they had more severe respiratory problems
Modes of cannabis administration, cannabis and tobacco co-use, and associations with respiratory and cannabis use outcomes in a permissive medical cannabis state
https://www.sciencedirect.com/science/article/abs/pii/S0306460326001528

On lung collapse, a case report linking it to inhaled cannabis & e-cigarette use
Darth Vaper: The Pneumothorax Strikes Back
https://academic.oup.com/ajrccm/article/212/Supplement_1/aamag162.6524/8686876

⚠️ Harms ⚠️

In people who use cannabis, a review of health education interventions to reduce their cannabis & tobacco use
Health education interventions to reduce cannabis and tobacco smoking-related harms among people who use cannabis: a systematic review
https://www.ovid.com/journals/hedre/fulltext/10.1093/her/cyag016~health-education-interventions-to-reduce-cannabis-and
“Overall, school-based preventive programmes showed mixed effects, while motivational interventions more consistently reduced cannabis but not tobacco smoking.”

In the Swiss pilot of regulated cannabis sales & profiles of the different users, coping-related use was associated with higher problematic cannabis use
Who uses legal cannabis and why? Cluster profiles of participants in a Swiss regulated sales pilot trial
https://www.sciencedirect.com/science/article/pii/S2772724626000387

📑 Reviews 📑

For neuroinflammation, a review of the effects of various cannabinoids
Effects of phytocannabinoids, synthetic and semi-synthetic cannabinoids on microglia and astrocytes: Review of neuroinflammatory mechanisms
https://academic.oup.com/jnen/advance-article/doi/10.1093/jnen/nlag049/8679007

For gum disease & CBD, a review found that it modulated inflammatory signaling, reduced bone loss & caused antimicrobial & antibiofilm (slimy aggregations that resist treatment) effects against oral microorganisms
Cannabidiol in Periodontal Therapy—Is There Hope or Just a Bias? A Systematic Review
https://www.mdpi.com/2227-9059/14/5/1163

For different types of pain, a review on targeting the endocannabinoid system
Endocannabinoid system modulation in acute, chronic, and neuropathic pain: reviewing experimental models, clinical evidence, and nanotechnology delivery
https://pubmed.ncbi.nlm.nih.gov/42154330/

For obesity, a review of targeting the endocannabinoid system & the enzyme FAAH (which breaks down anandamide)
Fatty acid amide hydrolase (FAAH) and the endocannabinoid system in obesity: Mechanistic insights and pharmacological opportunities beyond incretin-based therapies
https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.70511

On CBDV, a review of its mechanisms & relevance for epilepsy, autism, Rett syndrome & more
Cannabidivarin: current evidence on pharmacological activity, biopharmaceutical limitations and clinical prospects
https://link.springer.com/article/10.1007/s11101-026-10252-8

🐁 Preclinical 🐁

In a rat model of inflammatory pain, CBD, CBN & THCV reduced the hypersensitivity
Effect of cannabidiol, cannabinol and tetrahydrocannabivarin in managing inflammatory pain
https://www.nature.com/articles/s41598-026-51275-7_reference.pdf

In a mouse model of muscle atrophy, CBD lessened the muscle mass loss, reduced the oxidative stress & restored markers of the mitochondria (powerhouse of the cell)
Protective Effects of the Phytocannabinoid Cannabidiol on Disuse-Induced Muscle Atrophy through Modulation of Proteolysis and Mitochondrial Regulation
https://www.jstage.jst.go.jp/article/bpb/49/5/49_b26-00020/_pdf

In a rat model of testicular dysfunction due to a high-fat diet, the terpene beta-caryophyllene restored sperm count & sperm motility as well as elevating testosterone levels
β-caryophyllene mitigates high fat diet-induced testicular dysfunctions by targeting JNK/ERK-1 and JAK-1/STAT-3 pathways in rats
https://pubmed.ncbi.nlm.nih.gov/42143136/

In a mouse model of Alzheimer’s disease, the probiotic Lactobacillus mucosae reduced the brain’s oxidative stress, neuronal damage & cognitive impairment via the CB2 receptors
Lactobacillus mucosae Reduces Neuronal Oxidative Stress in Alzheimer’s Disease via the Regulation of CB2 Signaling
https://www.imrpress.com/journal/JIN/25/5/10.31083/JIN48598
One more to add to our list of natural cures that utilize the endocannabinoid system…

🆕 Novel Studies 🆕

(a grab bag section for cool & new stuff)

On YouTube videos on cannabis hyperemesis syndrome, researchers rated only 25% as useful & 2% as exemplary
Assessing the Quality of YouTube Videos About Cannabinoid Hyperemesis Syndrome
https://assets.cureus.com/uploads/original_article/pdf/480233/20260518-95243-zh4vrb.pdf
Unfortunately, they did not list the ~100 videos that they reviewed, but here’s hoping that my 4 videos on the subject are at least in the 25% considered useful.

For the corn earworm infesting cannabis, on the effects of cannabinoid & terpene levels on their egg laying & larval fitness, with higher CBD linked to lower larval survival
Evaluating the effects of terpene and cannabinoid variation in hemp (Cannabis sativa) germplasm on Helicoverpa zea oviposition and larval fitness
https://link.springer.com/article/10.1007/s10340-026-02044-y
One of the great mysteries of the cannabis plant is: why did it ever evolve to produce these metabolically expensive cannabinoids? One theory is protection from the harsh UV lights of the Eurasian steppes, but another theory is that they are a second-line defense against insects after the primary defense of terpenes. So while they don’t have to be mutually exclusive, this is one piece of evidence in favor of the “insect protection” model.

Lex’s roundup of fav newsletters:
#Canna: Marijuana Moment, Cannabis Law Report, Cultivated, Cannabis Musings (oy vey), Talking Joints Memo, Sticky Bits, Highly Objective, Cannabitch, Indigenous Cannabis Industry Association, Dr. Peter Grinspoon, Doctor Approved, Medical Marijuana Memory Blog (by Dame Alice O’Leary Randall)
#DrugWar: InSight Crime, Marshall Project, Students for Sensible Drug Policy
#HarmReduction: Filter, Drug Data Decoded, International Drug Policy Consortium, National Harm Reduction Coalition, Canadian Drug Policy Coalition
#Psychoactives: Psychedelic Alpha, Ecstatic Integration, ICEERS, Substance, The Microdose

📰 US Headlines & Fav Articles

In Delaware, terminally ill patients can now use cannabis in the hospital (though not smoking or vaping)
https://www.marijuanamoment.net/delaware-governor-signs-bill-allowing-medical-marijuana-use-in-hospitals-by-terminally-ill-patients/

In the New York State medical cannabis program, surveys found geographical inaccessibility & the high cost of certification & products to be the central barriers
Patient Experiences and Access Barriers in the New York State Medical Cannabis Program: Findings from Two Consecutive Cross-Sectional Surveys, 2023 to 2024
https://www.sciencedirect.com/science/article/pii/S0149291826001335

‘America’s First War on Drugs Was Also a War on Jazz’
https://lithub.com/americas-first-war-on-drugs-was-also-a-war-on-jazz/
An excellent history of the early War on Drugs under Harry Anslinger & how viciously he pursued certain Black cultural figures like Billie Holiday & Thelonious Monk.

🌐 International Updates 🌐

In Canada, an editorial against cannabis legalization as trading reduced crime for increased health problems
Cannabis Legalization Outcomes in Canada: Trading Off Increased Health Problem for Reduced Crime Burdens Is Not Good Enough
https://journals.sagepub.com/doi/full/10.1177/07067437261454772
“About one-in-four (25%) of active cannabis consumers use cannabis on a daily/near-daily basis—an intensive use pattern that commonly involves high-potency products and that is strongly associated with various—acute and chronic—cannabis-related harms (e.g., cannabis use disorder, mental health problems)^.²^–⁵ Depending on the survey source, 40–60% of past-year users were estimated by the ASSIST’s cannabis involvement scale to be at moderate-to-high risk for cannabis use-related problems, a proportion that has been increasing over-time.²^,³ Nationally, cannabis-related hospitalizations increased from 23,322 in 2017/18 to 34,013 in 2024/25; in Ontario, the annual numbers of both cannabis-related Emergency Department visits (5,645–12,424) and cannabis-related hospitalizations (4,215–7,793) approximately doubled between 2015 and 2024. In addition, numerous other studies have documented increases for a variety of severe cannabis-related physical (e.g., poisonings, injuries) and mental health (e.g., psychosis, self-harm) harms associated with legalization.⁶”

On the history of the corridos (ballads in traditional Mexican style) during both the Mexican Revolution & the rise of narcoculture
The Mexican Corrido as Cultural and Political Narrative
https://www.proquest.com/openview/95b52fccbc065324d19001cf267f1bf1/1

⚖️ Business, Laws & Education ⚖️

For the first time, the US DOJ sued a cannabis MSO to clawback $8M from an “erroneous” 280E tax refund
https://businessofcannabis.com/doj-sues-terrascend-for-8-3m-in-first-known-280e-refund-clawback/

In medical cannabis pharmaceuticals, on the Good Manufacturing Practice requirements, extraction & purification technologies & batch-to-batch reproducibility
Active Pharmaceutical Ingredients in Medical Cannabis: Manufacturer Profiling, Standardization Challenges, and Technological Compatibility
https://www.mdpi.com/2218-0532/94/2/41

For business operational efficiency & US medical cannabis laws, this Korean analysis found that medical cannabis “significantly reduces efficiency, particularly among firms with greater operating complexity”
Medical Marijuana Legalization and Firm Operational Efficiency
https://www.earticle.net/Article/A484691
This makes me glad to not be a firm with “greater operating complexity”. The most complex part of my business day is figuring out how to get it all done before picking up the kids…

🚓 The War on Drugs 🚓

Another strike in the eastern Pacific against a suspected drug-trafficking vessel killed one person
https://nypost.com/2026/05/27/us-news/us-military-kills-alleged-narco-terrorist-in-lethal-strike-on-drug-trafficking-vessel-in-eastern-pacific/

‘Inside Thailand’s British Drug Mule Gangs’, a documentary by the UK’s Channel 4
https://cannabislaw.report/channel-4-uk-documentary-inside-thailands-british-drug-mule-gangs/

In Switzerland, a man was caught with 50 kg of cannabis & claimed it was for personal use
https://cannabislaw.report/switzerland-man-caught-with-50-kilos-of-cannabis-for-personal-use/

In Faro, Portugal, a man running from his car crash dropped packets of hashish as he fled
https://cannabislaw.report/portugal-police-in-faro-have-arrested-a-30-year-old-man-who-allegedly-fled-the-scene-of-a-car-crash-on-the-a22-motorway-leaving-behind-packages-of-hashish-he-was-trying-to-transport/

WoD Research

For racialized arrests, adult-use cannabis laws did not reduce racial disparities in non-cannabis drug arrests or other crimes & may even widen the disparities
Recreational Marijuana Laws and Racial Disparities: New Evidence on Arrests and Deaths of Despair
https://www.journals.uchicago.edu/doi/abs/10.1086/738358

In China after the Second Sino-Japanese War (late 1930s), on the government’s control of narcotics & its monopoly in Taiwan
The Nanjing Nationalist Government’s institutional attempt on the control of the narcotic drug and predicament of its monopoly
https://www.tandfonline.com/doi/abs/10.1080/17535654.2026.2641375

In Nigeria, on the history of drug crime & societal instability
Drug Crime and Societal Instability in Nigeria: A Historical Examination of the Relationship Between Drug Trafficking and Social Disorder, 1989- 2022
https://www.acjol.com/paper/7374.pdf

On the Silk Road 2, an analysis of drug names for early detection of novel psychoactives
From Language to Forensic Intelligence: Drug Name Recognition in the Cryptomarket Forum of Silk Road 2
https://link.springer.com/article/10.1007/s11196-026-10503-z

🛡️ Harm Reduction News 🛡️

Harm Reduction Research

In Portugal, interviews on the benefits of their drug policy of decriminalization
The Portuguese police experience with drug decriminalisation
https://www.tandfonline.com/doi/abs/10.1080/10439463.2026.2674973

For implementing drug checking services, on perspectives from harm reduction staff on the increased engagement, but also barriers such as legal risk, criminalization & organizational capacity
Shifting Perspectives: Harm Reduction Staff Perceptions of Drug Checking Implementation
https://journals.sagepub.com/doi/abs/10.1177/29767342261444522

🍄 Psychoactives, Psychedelics & Plant Medicines 🍄

Psychedelics & MDMA

In people with depression, a single dose of psilocybin caused rapid antidepressant effects that persisted for more than 3 months
Short-Term and Late-Term Effects of Psilocybin on Symptoms in Major Depression A Randomized Clinical Trial
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2849099

In people with suicidal behavior who used ayahuasca in a neo-shamanic context, interviews on the positive effects
Ayahuasca use and improvements in suicidal behavior: An exploratory qualitative study
https://www.sciencedirect.com/science/article/pii/S2950484826000160

In Swiss physicians giving psychedelic-assisted therapy, a survey of their clinical methods
Psychedelic-assisted therapy: a survey on the clinical methods of Swiss physicians
https://journals.sagepub.com/doi/pdf/10.1177/20451253261448745

In people taking DMT, on a list of the effects
DMT, Madness, and Healing: Psychosis Model, Therapy Model, and Their Relations to Mystical Experiences and Positive Emotionality
https://assets-eu.researchsquare.com/files/rs-9640916/v1/cd589555-b143-483f-8196-d4269d76dfd1.pdf

For eating disorders & psychedelics, a meta-synthesis of 8 studies found themes of transformation
Understanding experiences of psychedelic treatments for eating disorders: a meta-synthesis of qualitative studies
https://link.springer.com/article/10.1186/s12916-026-04929-2

For autism & psychedelics, a review of the evidence & mechanisms
Classic psychedelics and autism spectrum disorder: preclinical evidence, mechanistic insights and unresolved challenges
https://www.sciencedirect.com/science/article/pii/S0149763426002186

On psychedelic harm reduction, a new book
Psychedelic Harm Reduction
https://link.springer.com/book/10.1007/978-3-032-21107-1#page=192

Ketamine

For treatment-resistant depression, an editorial on Norway’s reimbursement of off-label IV ketamine use as a treatment
Transforming treatment-resistant depression care in Norway: Public health reimbursement for off-label intravenous ketamine
https://journals.sagepub.com/doi/pdf/10.1177/20503245261452347

For suicidal ideation & depression, a trial found that buprenorphine sustained & enhanced the effects
Low-Dose Buprenorphine Following Ketamine Treatment for Suicidal Ideation in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial
https://psychiatryonline.org/doi/pdf/10.1176/appi.ajp.20250840

For depression & oral ketamine, a meta-analysis of 8 studies found significant effects
Short-term effects of oral ketamine for the treatment of depression: A systematic review and meta-analysis of randomized controlled trials
https://www.sciencedirect.com/science/article/pii/S1876201826001875

In people using ketamine for depression, their most common adverse experiences were sleep disturbances as well as appetite & weight changes
Treatment-emergent psychiatric adverse events in patient-reported outcomes during ketamine use for major depressive disorder: a retrospective analysis
https://link.springer.com/article/10.1007/s43440-026-00867-1

For responsiveness to ketamine’s antidepressant effects, on using a microRNA as a predictive biomarker
Unraveling MicroRNA-29a as a potential predictive biomarker of depressive-like phenotype and ketamine antidepressant efficacy: an integrative in vivo and in vitro approach
https://www.jbc.org/article/S0021-9258(26)01349-9/pdf

On the complications from ketamine, a review of the negative “urological, neurological, neuropsychiatric & hepatobiliary [liver]” effects
Beyond the High: A Narrative Review of the Chronic Complications of Recreational Ketamine Use
https://www.imrpress.com/journal/BJHM/87/5/10.31083/BJHM53976

For unipolar & bipolar depression, a review found that the most predictive factors were body mass index, dissociation & previous neuromodulation treatments
Clinical Predictors of Antidepressant Effects of Ketamine and Esketamine in Treatment-Resistant Unipolar and Bipolar Depression: A Systematic Review
https://link.springer.com/article/10.1007/s40263-026-01296-7

Kratom

Among people using kratom, a trial found no participants meeting the threshold for clinically meaningful withdrawal
Assessment of Abuse Potential-Related Effects of Oral Dried Kratom Leaf Powder in Healthy Normal Participants Following Single and Multiple Daily Doses
https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdf/10.1002/dta.70089

In kratom users, public health data found associations with cannabis use, substance use disorders & serious psychological distress
Kratom Use and Associations With Mental Health in the United States
https://www.ovid.com/jnls/journaladdictionmedicine/abstract/10.1097/adm.0000000000001701~kratom-use-and-associations-with-mental-health-in-the-united

For kratom, a case report of its use leading to multi-system organ failure & death
Kratom Kills: Mitragyna Speciosa Induced Multi-system Organ Failure and Death
https://academic.oup.com/ajrccm/article/212/Supplement_1/aamag162.4879/8684306

For kratom & liver injuries, a review of 32 cases
Liver Injury Associated With Kratom (Mitragyna speciosa): A Systematic Review
https://www.ovid.com/jnls/journaladdictionmedicine/abstract/10.1097/adm.0000000000001663~liver-injury-associated-with-kratom-mitragyna-speciosa-a

On 7-hydroxymitragynine (a potent alkaloid from kratom found only at low levels naturally in the plant), a review of its effects on the opioid receptors & case reports of harms
7-Hydroxymitragynine (7-OH): Clinical Implications of a Potent, Unregulated Opioid Partial Agonist Derived from Kratom (Mitragyna speciosa)
https://link.springer.com/article/10.1007/s40429-026-00755-x

🍃 The Plant & its Products 🍃

🌱 Growing 🌱

In medicinal cannabis, the impact of planting density & the duration of the vegetative stage
The Impact of Planting Density and Vegetative Duration on Yield Optimization and Cannabinoid Stability in Medicinal Cannabis Under Controlled-Environment Cultivation
https://www.mdpi.com/2311-7524/12/5/619

For best agronomic practices, a Spanish trial found that cultivar & time explained most of the variance
Replication Data for Influence of Agronomic Practices on the Bioactive Compound Production in Cannabis sativa L.
https://portalinvestigacio.uib.es/documentos/6a0355516fd4f64b19ec2a49?lang=de

For hemp stalk quality, on the effects of cultivar, year & flower harvest
How do cultivar, year, and flower harvest affect industrial hemp stalk quality?
https://www.sciencedirect.com/science/article/pii/S092666902600871X

On hop latent viroid as the greatest threat to the cannabis industry
The Birth of a Silent Killer in the Cannabis Production Industry
https://giahpezeshksj.ut.ac.ir/article_106954_en.html

For testing mycotoxins in US cannabis flower & concentrates, failure rates are low
Mycotoxin Trends of Cannabis Compliance Testing in Cannabis Flower and Concentrates in the United States
https://www.sciencedirect.com/science/article/abs/pii/S0149291826001037

In hemp grain infected with Fusarium, on the limits of detecting mycotoxins
Separation of trichothecene mycotoxins in a matrix of hemp (Cannabis sativa L.) seed, and quantification of deoxynivalenol in hemp grain infected with Fusarium graminearum
https://scijournals.onlinelibrary.wiley.com/doi/pdf/10.1002/jsf2.70073

In 25 Iranian landrace populations, a genetic, environmental & morphological analysis
Integrating temporal morphophysiological and genomic markers for precise classification of flowering time in cannabis
https://www.nature.com/articles/s41598-026-53686-y_reference.pdf

In Kenya, an analysis of the local hemp-type cannabis
Phytochemical screening and multi-analytical characterization of Cannabis sativa, cultivated in Mt Kenya region, Kenya
https://link.springer.com/article/10.1007/s44473-026-00159-9

⚙️ Extracting, Analyzing & Formulating ⚙️

A review on analyzing cannabis with ambient ionization mass spectrometry
Application of Ambient Ionization Mass Spectrometry to the Analysis of Cannabis
https://www.annualreviews.org/content/journals/10.1146/annurev-anchem-080524-100042

For Moroccan cannabis, on optimizing an ultrasound-assisted extraction
Optimization of Ultrasound Assisted Extraction of Moroccan Cannabis Sativa seed oil using Response Surface Technology: Yield and Antioxidant Activity
https://revues.imist.ma/index.php/morjchem/article/view/55129

If CBD is degraded by a combination of light, heat & oxygen, it can have visible yellowing that acts as a simple quality indicator
Storage-induced color change as an indicator of Cannabidiol degradation in MCT oil
https://www.sciencedirect.com/science/article/pii/S0926669026008435

For analyzing extracts, using a patented absorbance-transmittance excitation-emission matrix spectroscopy with machine learning
Quantification of 14 Major and Minor Cannabinoids with Absorbance–Transmittance Excitation–Emission Matrix Spectroscopy and Machine Learning
https://journals.sagepub.com/doi/abs/10.1177/25785125261449640

For measuring CBD & THC, modeling different operating conditions
Multivariate Robustness Modeling of Cannabidiol and Δ9-Tetrahydrocannabinol Quantification Using Two-Level Full Factorial Design
https://www.mdpi.com/2218-0532/94/2/42

On using an open-source lab for screening CBD oils
Faster operation of 2LabsToGo-Eco using Debian 13, Django 5, and Raspberry Pi 5, verified via screening of cannabidiol-containing oils
https://link.springer.com/article/10.1007/s00764-026-00406-x

On creating cannabis-infused nanoparticles for antibacterial & anticancer activities
Green Synthesis of CeO2 Nanoparticles Using Cannabis sativa L. Seed Extract for Antibacterial and Breast Cancer Applications
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.202507256

🍞 Food & Nutrition 🍞

For cannabis beverages eroding their containers, those with a low pH had a significant erosive potential
Erosive Potential of Commercially Available Cannabis Beverages
https://pubmed.ncbi.nlm.nih.gov/42138577/

For hemp waste after CBD extraction, an analysis of its properties & potential as a plant protein ingredient
Structural and functional properties of hemp protein isolates from industrial hemp waste after cannabidiol extraction
https://www.sciencedirect.com/science/article/abs/pii/S0268005X26004832

On hemp silage (animal feed), on the effects of different additives on the nutritional quality & fermentation
Effects of different additives on nutritional quality and fermentation characteristics of industrial hemp silage
https://www.jafs.com.pl/pdf-218807-140081?filename=Effects-of-different-addi.pdf

🏗️ Industrial Uses & Fiber 🏗️

For biofuel production, a review of using hemp
Exploring the potential of industrial hemp for sustainable biofuel production
https://link.springer.com/article/10.1007/s13399-026-07162-2

In bitumen for road surfacing, adding a hemp biochar improved aging, increased rutting resistance & enhanced the mechanical strength but slightly reduced moisture damage resistance
Influence of hemp-based biochar from pyrolysis on bitumen properties and bituminous mixture performance
https://www.sciencedirect.com/science/article/pii/S2214509526003979

On creating compressed earth blocks using gelatinized starch & hemp fiber
Upcycling excavated soils into compressed earth blocks using low-dosage gelatinized starch and hemp fibers: comparative study between France and Côte d’Ivoire
https://www.sciencedirect.com/science/article/pii/S2590123026021481

For natural fiber mats for the transportation industry, on the mechanical properties of hemp versus other fibers
Comparative Evaluation of Structure–Processing–Property Relationships in Flax, Hemp, and Cattail Discontinuous fiber Thermoset Composites
https://4spepublications.onlinelibrary.wiley.com/doi/pdf/10.1002/pc.71196

On reinforcing epoxy composites with hemp fiber & nanoparticles
Advanced hemp-based hybrid composites: A study on the influence of various nanofillers on mechanical and morphological properties
https://jmmm.material.chula.ac.th/index.php/jmmm/article/view/2427

For building materials, on hemp-lime composites for lowering the carbon footprint
Sustainable masonry elements based on hemp–lime composites
https://www.ceeol.com/search/chapter-detail?id=1424816

For hemp-based insulation, an analysis of different formulations
Experimental study on the production and characterization of hemp-based insulating materials
https://openurl.ebsco.com/EPDB%3Agcd%3A12%3A39814604/detailv2?sid=ebsco%3Aplink%3Acrawler-gcd&id=ebsco%3Agcd%3A193696762&crl=c&jrnl=15842665&link_origin=none

For hemp insulation, on comparing different binders to create aerogels for more efficiency
Development of a novel hemp-based building material with enhanced thermal performance
https://www.frontiersin.org/journals/sustainability/articles/10.3389/frsus.2026.1844355/abstract

For soil stability, on enhancing it with hemp fibers & cement
Study of behaviour of hemp fibre reinforced clayey soil
https://www.taylorfrancis.com/chapters/edit/10.1201/9781003724964-34/study-behaviour-hemp-fibre-reinforced-clayey-soil-visvanathan-anusudha-prasad-raghavendra-stephen-simon-gideon-faslur-rahuman-muqadthasy-niyaf-mohamed-omary-nurdin-yash-kumar-poddar

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

For cannabinoids in medicine, a review of the advantages & adverse effects
Cannabinoids: Therapeutic Applications, Mechanisms, and Challenges in Modern Medicine
https://pubmed.ncbi.nlm.nih.gov/42163693/

🏥 Public Health & Bioassays 🏥

For pediatric trauma & cannabis, the levels did not change after the legalization of cannabis
Pediatric Trauma Trends Before and After Recreational Cannabis Legalization in Nevada: A Retrospective Repeated Cross-Sectional Study
https://www.mdpi.com/2227-9067/13/5/681

For detecting THC in spinal fluid, validation of a new analytical method
Detection of Delta9-THC in cerebrospinal fluid: New validation strategies for forensic and clinical toxicology applications
https://search.informit.org/doi/abs/10.3316/informit.T2026051800002191844250898

🧒 Adolescents & Young Adults 🧒

For young adults, exposure to cannabis advertising & price-based promotions are linked to initiation of cannabis use
How Cannabis Advertising and Price-Based Sales Promotion Shape Early Use: A National Study of Adolescents
https://www.tandfonline.com/doi/pdf/10.1080/10826084.2026.2670629

In young adult college students, they drew minimal distinctions between the health consequences of cannabis based on its cannabinoid contents or route of administration
Perceived effects of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) content on cannabis-related health risks and benefits
https://pubmed.ncbi.nlm.nih.gov/42149482/

In US young adults using cannabis, on how personality traits related to their usage
Latent profile analysis of personality characteristics among US young adults in relation to cannabis use and intentions over time
https://www.sciencedirect.com/science/article/abs/pii/S0306460326001619

On Snapchat, an analysis of the posts of college students about cannabis use
Sharing Over Viewing: Cannabis-Related Snapchat Content and College Student Use
https://link.springer.com/article/10.1007/s41347-26-00645-z

In Illinois, a thesis project found cannabis legalization was not linked to an increase in positive THC urine screens in young people
Changes in THC Positivity Rates in Adolescents Corresponding to Legalization of Recreational Marijuana in Illinois
https://escholarship.org/content/qt3p10k08h/qt3p10k08h.pdf

🧠 The Brain & Neurological Disorders 🧠

In brain scans of cannabis users, their levels of use were not linked to changes in the size of their hippocampus (a memory center of the brain)
Cumulative exposure to cannabis and hippocampus MRI in middle age: results from the coronary artery risk development in young adults (CARDIA) study
https://www.nature.com/articles/s41398-026-04096-1_reference.pdf

In people with cannabis use disorder, while fMRI-neurofeedback reduced their brain hyperactivity in regions related to cravings, they experienced no changes in subjective cravings, anxiety or focus
Exploring fMRI-neurofeedback to reduce craving-related brain activity in people with cannabis use disorder: A feasibility study
https://www.sciencedirect.com/science/article/pii/S0306460326001516

For neurodegenerative disorders, on a drug to modulate both a serotonin receptor & the enzyme FAAH (which breaks down anandamide)
New chalcogen-optimized 1,3,5-triazines as dual 5-HT6R/FAAH modulators: A versatile approach to neurodegenerative disorders
https://www.sciencedirect.com/science/article/pii/S0223523426004113

For CBD derivatives & neuroinflammation, a thesis project on CBD-derived chalcone intermediates
Exploring Synthesized CBD Derivatives: Implications of Therapeutic Strategies for Neuroinflammation
https://scholarcommons.sc.edu/cgi/viewcontent.cgi?article=1885&context=senior_theses

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

In people with cannabis use disorder, four different cannabis craving trajectories were identified, with high craving trajectories associated with greater baseline anxiety, depression & obsessive-compulsive symptoms as well as poorest treatment outcomes
Longitudinal craving profiles in cannabis use disorder: A latent class growth analysis of the achieving cannabis cessation: Evaluating N-Acetylcysteine Treatment (ACCENT) (CTN-0053) trial
https://www.sciencedirect.com/science/article/abs/pii/S0376871626001894

In Alberta, Canada, legalization of cannabis did not lead to an increased need for addiction treatment
What Is the Impact of Recreational Cannabis Legalization in Canada on Substance Use Treatment in Alberta?
https://www.ovid.com/jnls/cja/fulltext/10.1097/cxa.0000000000000274~what-is-the-impact-of-recreational-cannabis-legalization-in

In people with schizophrenia, those who reported cannabis use were predominantly young men & marked by more positive psychotic symptoms, behavioral dyscontrol & unstable short-term outcomes
Schizophrenia associated with cannabis use in the psychiatry département in Toamasina, Madagascar: Clinical and sociodemographic characteristics
https://www.psychiatryjournal.in/archives/2026/vol8issue5/PartA/8-1-30-994.pdf

In young & aged mice, the terpene beta-caryophyllene at high doses caused impairments in attentional control, while in aged low-performing mice, low doses enhanced inhibitory control
β-caryophyllene, a CB2-selective phytocannabinoid, differentially modulates attention and inhibitory control in low- and high-performing young and aged mice
https://link.springer.com/article/10.1007/s00213-026-07093-w

🦠 The Immune System & Microbial 🦠

In people with lupus, their lymphocytes (a class of white blood cells) had higher levels of CB2 receptors & lower levels of CB1 receptors, with CB1 receptor expression strongly correlated with disease activity
Cannabinoid receptor expression profiling in lymphocyte subsets reveals clinically relevant immune patterns in SLE
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1848747/abstract

In a mouse model of HIV, treatment with doxycycline had different effects on the levels of CB1 receptors in different brain regions
Longitudinal Analysis of Cannabinoid Type 1 Receptor in HIV-1 Tat Transgenic Mice Using PET Imaging and Western Blot Analysis
https://journals.sagepub.com/doi/abs/10.1177/25785125261450903

🍽️ The Guts, Nutrition & the Microbiome 🍽️

In a mouse model of intestinal injury from radiation (like in cancer treatments), the radiation caused increased levels of the CB2 receptor & activating that receptor as well as inhibiting the enzyme FAAH (which breaks down anandamide) protected the small intestine & spleen
CB2R agonism protects intestinal epithelium through β-catenin/HoxA10 loop in radiation injury
https://link.springer.com/article/10.1186/s12967-026-08268-x

In a mouse model of obesity, inhibiting the body’s CB1 receptors suppressed food intake & activated satiation in the brainstem & hypothalamus (regulates temperature, heart rate, sleep & hunger via hormones)
Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis
https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bph.70507

In a mouse model of acute pancreatitis, restoring levels of the endocannabinoid 2-AG reduced inflammation & lung injury
Disrupted endocannabinoid signaling contributes to systemic inflammation in acute pancreatitis
https://pubmed.ncbi.nlm.nih.gov/42153289/

🩸 The Liver, Drug Interactions & Cannabinoid Metabolism 🩸

In a mouse model of liver fibrosis (scarring) due to a high-fat diet, inhibition of the enzyme MAGL (which breaks down the endocannabinoid 2-AG) in liver cells caused less liver scarring & bone destruction
Inhibiting hepatocytes MAGL alleviates osteoporosis caused by high-fat diet-induced liver fibrosis in male mice
https://watermark02.silverchair.com/bvag114.pdf

In a rat model of hyperglycemia, insulin increased their liver levels of CB1 receptors while activation of the CB1 receptors caused enhanced lipid-producing effects in liver cells
Insulin increases expression of cannabinoid receptor 1 by suppressing lysosomal degradation via ERK signaling pathway
https://pmc.ncbi.nlm.nih.gov/articles/PMC13181381/

💨 The Lungs 💨

In a mouse model of acute lung injury, on a new drug derived from CBD that inhibits the TRPV4 receptor to lower inflammation & lung scarring as well as preserving the integrity of the pulmonary vascular barrier
Discovery of a novel cannabidiol-derived transient receptor potential vanilloid 4 inhibitor to reduce pulmonary edema and lung vascular permeability in mice
https://link.springer.com/article/10.1186/s11658-026-00939-3

👀 The Eyes 👀

In the eyes of people with & without schizophrenia, chronic cannabis use was linked to aberrations
Early-Onset Cannabis Use, Retinal Biomarkers, and Risk for Schizophrenia: Preliminary Study
https://www.clinicaltherapeutics.com/article/S0149-2918(26)00104-9/abstract

In horses, CBD caused no changes to their intraocular pressure or tear production
Short-Term Daily Oral Administration of Cannabidiol Does Not Impact Rebound Tonometry Intraocular Pressure or Schirmer Tear Test Values in Healthy Adult Horses
https://onlinelibrary.wiley.com/doi/pdf/10.1111/vop.70188

🎗️ Cancer & Chemotherapy 🎗️

In cervical cancer cells, the combination of THC & CBD with cisplatin caused diverse anticancer effects, including less DNA repair capacity & more autophagy (cellular recycling) & apoptosis (programmed cellular suicide)
Antiproliferative Effects of Cannabinoids and Cisplatin in Cervical Cancer Cells
https://www.ovid.com/journals/canrep/fulltext/10.1002/cnr2.70561~antiproliferative-effects-of-cannabinoids-and-cisplatin-in

In breast cancer cells, nabilone (a pharmaceutical cousin to THC) disrupted the complex between the CB2 receptor & human epidermal growth factor receptor 2-positive (HER2+, linked to treatment resistance)
Computational Characterization of Nabilone-Induced Disruption of the CB2-HER2 Receptor Complex in HER2+ Breast Cancer
https://journals.sagepub.com/doi/full/10.1177/11779322261449332

💊 Synthetic Cannabinoids & Hemp-Derived Cannabinoids 💊

For synthetic cannabinoids, a proposal to analyze their levels with a “Steric-Engineered Thermodynamic Gating” strategy
Steric-Engineered Thermodynamic Gating: Metastable Assemblies for Chemical-Class Discrimination of Synthetic Cannabinoids
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.3463809

🔬 Biochemical Discoveries & Research Tools 🔬

On synthesizing cannabistilbene I in a cell-free system for anti-inflammation
Cell-Free Synthesis of Cannabistilbene I: A Dual Acting Anti-Inflammatory from Cannabis sativa
https://pubs.acs.org/doi/full/10.1021/acs.jnatprod.6c00318

For allosteric modulators of cannabinoid receptors (which cause other molecules to bind more or less strongly at the main binding site), a thesis project on their design & biological evaluation
Allosteric modulators of cannabinoid receptors: design, synthesis and biological evaluation
https://repository.library.northeastern.edu/files/neu:ms425v55h

Thanks.
- lex

PS: For a godfather of the Cuban drums, ‘Soul Bag’ by Mongo Santamaria. Born Ramón Santamaría Rodríguez, his father nicknamed him Mongo, supposedly from a Mali word for ‘chief of the tribe’. And he certainly was. As a child in Havana, he learned the rumba & saw how music infused everything. He reminisced, “In the neighborhood where I came from we had all kinds of music, mostly from Africa. We did not leave it alone; we changed it our way. The music we made dealt with religion and conversation. The drum was our tool and we used it for everything”. He was mentored on the bongos & congas, dropping out of school to become a professional musician & began performing at the famed Tropicana club. In 1948 at the age of 29, he traveled to Mexico City with a dance team & was soon living in New York City. He spent 6 years playing with the likes of Tito Puente & Cal Tjader. In 1959, he recorded his own song “Afro Blue” which became the first jazz standard built upon the typical African 3:2 cross-rhythm. His big breakthrough into the mass market is said to have come about in 1962 because of a bad night at a Cuban nightclub in the Bronx. Only 3 people showed up to the show & so as Mongo talked with Herbie Hancock about the common threads between Afro-Cuban & African-American jazz, Hancock started playing his song “Watermelon Man”. Santamaria jumped up & started playing it as the whole band realized they had something magical on their hands. They were rushed into the studio & as soon as it was released, it shot to the top of the pop charts, the only one of his tunes to ever get there. But the success of the song led to him blending Afro-Cuban & African-American music as well as remixing Cuban-flavored versions of R & B & Motown songs. He spent the next decade on delightful albums in that vein before exploring rock, electric jazz, but always coming back to his roots as one of the great Cuban percussionists. He kept making the music until shortly before his death in 2003 at the age of 85.

This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.
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Neuropathic facial pain, back pain & vapes less toxic than pre-rolls

Lex Pelger WhiteWhaleCreations — Mon, 25 May 2026 12:54:20 GMT

Cannabinoids & The People,
or; Drugs & Drug Wars

🌟 This Week 🌟

(#hashtags for jumping to articles by searching for them with your browser)

Cannabis for sleep + THC & CBD for neuropathic facial pain + PEA for back pain
For US teens, more cannabis use than tobacco for the first time ever (#teenuse)
Ingestion: vapes less toxic than pre-rolls (#ingestion)
Devil’s Advocate Corner: when the EU declared CBD a reproductive toxicant, they had the data to back it up (#EUCBD)
Prenatal Cannabis Week: 9 studies
For CHS, topical capsaicin
Medical cannabis dispensaries & adult-use cannabis laws associated with reduced non-fatal opioid poisonings
For TBIs, ibogaine microdosing caused complete recovery in 2 people (#ibogainebrain)
Harm reduction: a US retrospective analysis found overdose prevention centers could have saved so many lives

[numbers for C&P#188: ~11k words, ~28 minutes reading time, 255 papers]

📌 Editor’s notes 📌:

Donate $13 to Realm of Caring for their 13^th anniversary! For funding & running cannabis studies, for offering free medical cannabis education to doctors & patients & for advocacy for medical cannabis, Realm of Caring is making a real difference in the lives of people who use medical cannabis.
From filmmaker James Gallagher, here’s the trailer for his new film ‘Humans of Cannabis: Pakistan’ about the farmers whose genetics changed the world & who now are getting left behind.

Hello everyone,
Welcome to the 188^th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news + the War on Drugs, harm reduction & other psychoactives. Support this work with a paid subscription or by buying me a coffee.

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(nothing new. I’m on solo-papa duty this week & still catching up from travels)

And as always, at the bottom is the album of the week: the choral masters of South Africa

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🍃 BEST OF CANNABINOID SCIENCE 🍃

(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)

⚕️ Clinical ⚕️

For cannabinoid hyperemesis syndrome, topical capsaicin (an ingredient of hot peppers that activates the TRPV1 receptor) greatly reduced abdominal pain & stopped vomiting in half of patients
Topical capsaicin for treatment of cannabis hyperemesis syndrome: a prospective observational study
https://www.tandfonline.com/doi/pdf/10.1080/24734306.2026.2667681

Among people using cannabis for sleep, the majority reported that it helped improve sleep quality & duration, though they had an association with cannabis use disorder
1034 Racial/Ethnic Differences in Cannabis Use Disorder Among Sleep-Motivated Cannabis Consumers Across Two Age-Distinct Cohorts
https://academic.oup.com/sleep/article/49/Supplement_1/A460/8674325

In people with sciatica-related back pain, PEA caused significant reductions in pain & improvements to daily functioning
Water-Dispersible Palmitoylethanolamide (PEA) Supplementation for Functional Improvement in Adults With Chronic Sciatica-Related Back Pain: A Pilot Clinical Trial
https://assets.cureus.com/uploads/original_article/pdf/485986/20260505-130741-hea997.pdf

For neuropathic facial pain, a case report of 2 females with a balanced THC:CBD formulation who experienced a marked painkilling response, improved functional performance & improved scores in physical domains & psychological well-being
Cannabinoid Therapy for Refractory Trigeminal Neuropathic Pain: Quantification of Somatosensory Alterations (QualST) by 3D Stereophotogrammetry—Two Case Reports
https://pmc.ncbi.nlm.nih.gov/articles/PMC13137124/

In people with arthritis, a survey found that they used cannabis to help with their pain & replace their painkilling medications
Perceptions regarding the use of cannabis in orthopaedics for treating musculoskeletal joint pain: A survey of arthritis patients
https://journals.sagepub.com/doi/full/10.1177/03000605261438343

In children & adults with epilepsy, a combination of CBD & a ketogenic diet had a 30-40% responder rate, with more improved outcomes associated with starting CBD before the ketogenic diet
Concurrent use of ketogenic diet therapy and cannabidiol in children and adults with epilepsy: A multicenter retrospective cohort study
https://www.sciencedirect.com/science/article/pii/S0920121126000859

For schizophrenia & cannabis use, a genetic analysis found that a certain immunogenetic background may increase vulnerability or reduce schizophrenia risk
HLA Class II Immunogenetic Profiles Shape Psychosis Outcomes in Cannabis Users: DRB5/DRB1*16 Vulnerability and DRB4/DRB3-Linked Protection, Particularly Against Schizophrenia
https://www.mdpi.com/2673-4087/7/3/56

In people taking CBD with & without low doses of THC, a study of how it moves through their body, with a few people in the CBD-only group testing positive for THC
The acute and chronic pharmacokinetic oral fluid profile of oral cannabidiol (CBD) with and without low doses of delta-9-tetrahydrocannabinol (Δ9-THC) in healthy human volunteers
https://www.ovid.com/journals/joat/abstract/10.1093/jat/bkaf102~the-acute-and-chronic-pharmacokinetic-oral-fluid-profile-of

For people microdosing cannabis, psychedelics & MDMA, a survey on their reasons (for cannabis, it was pain)
Prevalence and Reasons for Microdosing Cannabis, Psilocybin, LSD, and MDMA Among US Adults
https://www.sciencedirect.com/science/article/pii/S0749379726001248

For intraocular pressure, a meta-analysis of 5 studies found THC reduced it via the oral or topical route
Intraocular pressure-lowering effects of tetrahydrocannabinol drugs: a systematic review and meta-analysis
https://www.canadianjournalofophthalmology.ca/article/S0008-4182(26)00150-X/fulltext

For non-fatal opioid poisonings, in public health data from US people with employer-sponsored insurance, medical cannabis dispensaries & adult-use cannabis laws were associated with reduced non-fatal opioid poisonings
The association between state cannabis legalization and non-fatal opioid poisonings among adults with employer-sponsored insurance in the United States
https://www.sciencedirect.com/science/article/pii/S2211335526001257

For feline gingivostomatitis (a mouth & gum infection of swelling & sores), a case report where broad-spectrum CBD oil caused reduced inflammation, fewer ulcers & a marked improvement in the oral cavity, with the main negatives being sleepiness, diarrhea & decreased food intake
Cannabidiol Oil for Feline Gingivostomatitis Complex: A Case Report
https://www.preprints.org/frontend/manuscript/1e59ddc499321e0d1e2e4935ddbcd18a/download_pub

Prenatal Cannabis Use + Fertility

The EU declared CBD to be a “reproductive toxicant” (#EUCBD)
https://businessofcannabis.com/cbd-is-a-reproductive-toxicant-say-the-eu-in-a-major-blow-to-industry/
I saw many outraged takes online, but while I think this is a conservative take, they certainly have the data to back it up. You can see a review here & preclinical studies here on behavioral alterations, increased offspring anxiety (in females only) as well as repetitive behaviors, suppressed uterine contractions & altered thermal pain sensitivity & behavior changes.

In pregnancy, a call for a reproductive justice approach to cannabis use in Canada
Legacies of prohibition in Canada: calling for a reproductive justice approach to cannabis use during pregnancy
https://www.tandfonline.com/doi/pdf/10.1080/23311886.2026.2667551

For prenatal cannabis use, greater levels of depression, anxiety & irritability were associated with greater odds of using cannabis & cannabis use was associated with reductions in those symptoms
Use of cannabis to regulate negative affect in pregnancy: Bidirectional findings from an ecological momentary assessment study
https://psycnet.apa.org/record/2027-64415-001

For prenatal cannabis exposure, public health data found no association with later delays in motor or language attainment, but there was a delay in saying their first word
Mediating the Impact of Prenatal Cannabis Exposure on Neurobehavioral Disinhibition: The Role of Delayed Developmental Milestone Attainment
https://www.scilit.com/publications/04073617d47672d70759e7eb76f62b16

For cannabis use during pregnancy, a review of 10 studies found an association with low birth weight, smaller head circumference, cognitive & behavioral challenges & possible long-term vulnerability to substance use
Cannabis use during pregnancy: effects on mother and child
https://roam.macewan.ca/items/824638fa-d014-4ba9-826d-6cbe8846627d

For prenatal cannabis usage, self-reports can underestimate usage, especially among disadvantaged populations
Validity of Self-Reported Cannabis Use Based on Urine Toxicology Measures in a Population-Based Pregnancy Cohort in Michigan
https://www.tandfonline.com/doi/pdf/10.1080/10826084.2026.2670606
And I would never report my usage either. With the number of horror stories of people not able to leave the hospital with their newborn because of a positive cannabis test, this abominable practice means that no pregnant person should ever be honest about their cannabis use. Thanks to the heroes at Pregnancy Justice for keeping this issue at the forefront & fighting for change.

For cannabis use in pregnant people, there is a gap between those who wanted counseling about cannabis use & those who received counseling
Receipt of reproductive safety data among pregnant marijuana users and nonusers
https://link.springer.com/article/10.1007/s00737-026-01712-3

For perinatal cannabis use (before & after birth), an analysis of proposed clinical health messaging
Clinical Health Messaging for Perinatal Cannabis Use: Perspectives From Postpartum Individuals With Use During Early Pregnancy
https://journals.sagepub.com/doi/abs/10.1177/29767342261449036

In a mouse model of prenatal cannabis ingestion, the male offspring had decreased risk-taking behavior (which was enhanced by a high-fat diet) & locomotion, while female offspring were protected from alterations to emotional behavior & synaptic depression
Effects of maternal voluntary cannabis consumption on high fat diet-induced emotional alterations and gut microbiota in adult offspring
https://www.authorea.com/doi/pdf/10.22541/au.177374787.70081276/v1

In a tissue model of embryo implantation & placenta formation, CBG altered metabolism, extracellular matrix remodeling & the inflammatory response, suggesting a potential risk for adverse pregnancy outcomes
The impact of cannabigerol exposure on human endometrial stromal cells decidualization
https://www.sciencedirect.com/science/article/pii/S0300483X26000995

⚠️ Harms ⚠️

For the Australian Therapeutic Goods Administration, an analysis of the adverse event reports related to medical cannabis, with the top categories being psychiatric disorders, nervous system disorders & GI disorders, with 14 cases involving suicidal ideation or behavior
A retrospective analysis of voluntary adverse event reports to the TGA with higher THC medicinal cannabis products
https://journals.sagepub.com/doi/full/10.1177/00048674261445267

For treating lung cancer with immune checkpoint inhibitors, cannabis users had increased mortality & healthcare utilization
PP01.09: Cannabis Use in the Era of Immunotherapy: Real-World Outcomes in Advanced NSCLC Patients
https://www.sciencedirect.com/science/article/abs/pii/S1556086426002054

In someone with lesions from lupus, a case report on smoked cannabis being a trigger, but transitioning to edible & vaporized cannabis caused sustained remission of skin lesions
Refractory Subacute Cutaneous Lupus Erythematosus Resolved by Identifying an Unconventional Trigger: A Case of Cannabis-Induced Exacerbation
https://www.ovid.com/jnls/jdnaonline/fulltext/10.1097/jdn.0000000000000871~refractory-subacute-cutaneous-lupus-erythematosus-resolved

For pediatric cannabis ingestion & emergency department visits in British Columbia, Canada, the number of visits increased 55+ % from pre-legalization to post-legalization (though 90% of these were intentional use, assumedly with adolescents)
The impact of recreational cannabis legalization on pediatric emergency department visits in British Columbia, Canada
https://pmc.ncbi.nlm.nih.gov/articles/PMC13151408/

In people who regularly use cannabis, they had reduced heart reflex sensitivity & heart rate variability
Regular Cannabis Use Impairs Autonomic Cardiovascular Control in Humans
https://journals.physiology.org/doi/abs/10.1152/physiol.2026.41.S1.2300303

In frequent cannabis users, they had inconsistent perceptions of self & worse diet quality
Associations Between Cannabis Consumption, Stability of Self-Perception, and Diet Quality
https://journals.physiology.org/doi/abs/10.1152/physiol.2026.41.S1.2300496

In young people who use cannabis, a review of 21 studies found evidence of decreased IQ, lower executive function & decreased memory
How does cognition change over time in young people who use cannabis recreationally? A narrative review of the longitudinal literature to date
https://link.springer.com/article/10.1007/s00213-026-07072-1

In breast reduction surgery, cannabis use was associated with increased risk of bruising & delayed wound healing
The Impact of Marijuana Use on Postoperative Outcomes in Reduction Mammaplasty: Risks, Complications, and Considerations
https://www.sciencedirect.com/science/article/pii/S1748681526002664

For cannabis use disorder, a review of it as a disorder of motivational dysregulation
Cannabis Use Disorder as a disorder of motivational dysregulation: a systematic review of clinical, neurocognitive, and treatment evidence
https://www.tandfonline.com/doi/abs/10.1080/10550887.2026.2667987

On drugs for cannabis use disorder, a book chapter
Pharmacotherapy for Cannabinoid Use Disorder
https://link.springer.com/rwe/10.1007/978-3-031-57159-6_77-1

For synthetic cannabinoid abuse, a Russian analysis of rehabilitation models
Ethno-territorial features of psychotherapy rehabilitation models in addictive communities abusing synthetic cannabinoids
https://www.tandfonline.com/doi/abs/10.1080/15332640.2026.2657005

A case report of a stroke induced by synthetic cannabinoids
When high turns harmful: Synthetic cannabinoid-induced stroke in a patient with cryptogenic risk factors
https://institutionalrepository.aah.org/cgi/viewcontent.cgi?article=2766&context=advocategme

For synthetic cannabinoids, a case report of memory loss & multisystem toxicity
Synthetic Cannabinoid Use Complicated by Multiorgan Dysfunction
https://scholarlyworks.corewellhealth.org/corewellhealth_west_research_posters/159/

For the synthetic cannabinoid HHC, a case report of acute kidney injury
Hexahydrocannabinol-induced rhabdomyolysis and acute kidney injury: a case report combining comprehensive toxicokinetic and metabolomic investigations
https://link.springer.com/article/10.1186/s42238-026-00435-7

For vaping, a negative review on oxidative stress, inflammation & endothelial damage
The Cardiopulmonary Complications of Vaping
https://journals.lww.com/cardiologyinreview/fulltext/9900/the_cardiopulmonary_complications_of_vaping.833.aspx

📑 Reviews 📑

For the runner’s high, a review of the endocannabinoids as a neuromodulatory mechanism
The Neurochemical Orchestra of the Runner’s High: A Narrative Review of Neuromodulatory Mechanisms with a Focus on Endocannabinoids
https://journals.sagepub.com/doi/pdf/10.1177/10738584261440907

For substance use disorders, a commentary on the benefits of California Sober
Redefining Recovery: The Expanding Cannabis Landscape and Its Implications for the California Sober Approach in Addiction
https://link.springer.com/article/10.1007/s11469-026-01660-0

In brain scans of cannabis users, a review of neuroimaging studies
What Do Thirty Years of Neuroimaging Research Tell Us About Recreational Cannabis Use and Brain Integrity? A Narrative Review of the Multimodal Neuroimaging Evidence to Date
https://www.tandfonline.com/doi/pdf/10.2147/SAR.S584766
“Consistent evidence showed that acute intoxication with delta-9-tetrahydrocannabinol (THC) was associated with greater brain activity in fronto-striatal pathways. For regular cannabis users compared to controls, there was consistent cross-sectional evidence of lower hippocampal volumetry and white matter microstructure of the superior longitudinal fasciculus, and of different fronto-striatal activity and connectivity during cue-reactivity tasks and resting-state. In cannabis users, there was emerging evidence from Positron Emission Tomography studies of altered neurochemistry in fronto-striatal pathways (eg, lower N-acetyl aspartate); lower glucose metabolism in the frontal cortex; and lower density of cannabinoid receptors, which may reverse with abstinence.”

In people with gastroparesis (delayed gastric emptying), a review of 38 studies found cannabinoids improved total symptom scores & caloric intake even while paradoxically slowing gastric emptying
Cannabis-Based Medicines in Gastroparesis and Related Syndromes
https://www.atlanticare.org/sites/default/files/pdf/2026-ResearchDay/Cannabis-Based%20Medicines%20in%20Gastroparesis%20and%20Related%20Syndromes-Poster-Dave%20Che.pdf

In wound healing, a review of 18 studies found topical cannabis or CBD hydrogels improved collagen formation, the development of new blood vessels & wound closure
Cannabis sativa (Vijaya) in Wound Healing: A Systematic Review of Preclinical and Clinical Evidence
https://www.researchgate.net/publication/404394344_Cannabis_sativa_Vijaya_in_Wound_Healing_A_Systematic_Review_of_Preclinical_and_Clinical_Evidence

For autoimmune diseases, a review of the potential of cannabinoids
Cannabinoids in autoimmune diseases: mechanistic insights and translational challenges
https://www.sciencedirect.com/science/article/abs/pii/S0006295226003655

For adolescent psychiatry, a review on using CBD
Integrating Cannabidiol into Adolescent Psychiatry: Clinical Applications and Safety-Risk Profile for Treatment of Anxiety, Depression, and Post-traumatic Stress Disorder
https://www.benthamdirect.com/content/journals/aps/10.2174/0122106766389534251023105458

For neurodegenerative diseases, a review of the cannabinoids helping via the microglia (guardian immune cells of the brain)
Cannabidiol and other non-psychotropic cannabinoids from Cannabis sativa as therapeutics for microglial-mediated neuroinflammation and neurodegeneration
https://link.springer.com/article/10.1186/s42238-026-00445-5

In traumatic brain injury, a review on modulating the endocannabinoid system
Molecular and Genetic Mechanisms of Traumatic Brain Injury: The Endocannabinoid System as a Modulatory Axis
https://www.preprints.org/frontend/manuscript/b07e18656f4edcc62608db2a1557ce49/download_pub

In sepsis (an immune system overreaction to an infection), a review of targeting the endocannabinoid system for the dysfunctions of the microvascular system (small blood vessels)
Microvascular Effects of Endocannabinoid Signaling in Sepsis: A Mechanistic and Systematic Review
https://onlinelibrary.wiley.com/doi/pdf/10.1111/micc.70062

In neuropathy from chemotherapy, a review of 3 trials found no improvements
Cannabinoids in the Treatment of Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review of Randomized Controlled Trials
https://www.tandfonline.com/doi/full/10.1080/15360288.2026.2664668

For inflammation & oxidative stress, a review on the potential of the cannabinoids (nice chart)
Harnessing Cannabinoids to Target Inflammation and Oxidative Stress in Translational Medicine
https://jintb.org/index.php/jintb/article/view/30

For memory impairment from cannabinoids, a review of the molecular mechanisms
Memory impairment and chronic high-dose Δ9-THC/cannabis exposure: a narrative review of molecular mechanisms underlying neurotoxic effects
https://link.springer.com/article/10.1007/s00213-026-07070-3

For the GPR18 receptor, a review of its function & unclear links to the endocannabinoid system (nice charts)
Targeting GPR18: Structural modelling, ligand discovery, and therapeutic potential in neuroinflammatory disorders
https://www.sciencedirect.com/science/article/pii/S0006295226003710

For the phospholipase enzyme superfamily, on how it implements many of its wideranging changes via endocannabinoids
The Phospholipase A2 Superfamily in Health and Disease: From Lipid Signaling to Inflammation, Cancer, and Neurodegeneration
https://www.researchgate.net/publication/404326543_The_Phospholipase_A2_Superfamily_in_Health_and_Disease_From_Lipid_Signaling_to_Inflammation_Cancer_and_Neurodegeneration

🐁 Preclinical 🐁

In a rat model of phantom limb pain, the combination of CBD, THC & beta-caryophyllene lowered immune system reactivity, lessened inflammation & decreased pain via inhibition of GABA (the brain’s most common inhibitory neurotransmitter) in the spinal cord
Targeting Phantom Limb Pain with Cannabinoids in a Rat Model
https://scholarship.miami.edu/esploro/outputs/journalArticle/Targeting-Phantom-Limb-Pain-with-Cannabinoids/991033050794802976

In a rat model of PTSD, in males, THC disrupted fear memory reconsolidation (a good thing), but in females, this only occurred at estrus & diestrus, not at proestrus
Sex-specific role of microglia in Δ9-tetrahydrocannabinol-induced disruption of fear memory reconsolidation
https://www.nature.com/articles/s41386-026-02434-x

In a mouse model of diet-induced obesity, THC as well as cannabis extracts reduced body weight & fat mass & normalized adipokines (cytokines from fat cells), while cannabis extracts (but not THC) also normalized glucose clearance
Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet‐induced obesity
https://physoc.onlinelibrary.wiley.com/doi/pdfdirect/10.1113/JP290431

In a mouse model of intestinal stem cells damaged by radiation (as in cancer treatment), CBD rescued the dysregulation of their fatty acids & enhanced their proliferation
Cannabidiol triggers fatty acids β-oxidation mediated by Stat2 to facilitate intestinal stem cells regeneration post radiation
https://www.nature.com/articles/s12276-026-01711-5

In a rat model of spinal cord injury, vaping THC altered breathing parameters
THC exposure alters ventilation after cervical spinal cord injury
https://journals.physiology.org/doi/abs/10.1152/physiol.2026.41.S1.2300460

In a rat model of Alzheimer’s disease, the combination of intense exercise & CBD improved cognitive impairment
Combating cognitive decline in a rat model of Alzheimer’s disease: The role of high-intensity interval training and cannabidiol administration in modulating microRNA-124, BACE1, and nestin
https://cjn.tums.ac.ir/article_40594.html

In a mouse model of metabolic dysfunction associated steatotic liver disease (formerly known as fatty liver disease), this thesis project found that both CBD & CBG decreased liver fatness via the synthesis of lipids & the reduction of oxidative stress
Cannabinoid Modulation of Metabolic Dysfunction Associated Steatotic Liver Disease in a Mouse Model
https://digscholarship.unco.edu/cgi/viewcontent.cgi?article=1133&context=honors

In a mouse model of pain, CBD inhibited the ion channel Piezo2 to mediate its painkilling effects
Piezo2 mediates cannabidiol-induced analgesia of mechanical allodynia
https://langtaosha.org.cn/lts/en/preprint/view/197

In rats taking THC, different strains of rats experienced different effects
An Assessment of THC-Associated Physiological Effects in HS and WKY Rats (Abstract ID: 269631)
https://jpet.aspetjournals.org/article/S0022-3565(26)01019-0/abstract

In rats, CBG (at high doses) reduced locomotor activity but not anxiety-like behavior
Cannabigerol reduces locomotor activity but not anxiety-like behavior in naive rats
https://journals.physiology.org/doi/abs/10.1152/physiol.2026.41.S1.2344445

In a zebrafish model of type II diabetes, CBD did not significantly lower blood glucose levels but did increase performance on optomotor responses
The impact of cannabidiol (CBD) in hyperglycemic zebrafish (Danio rerio)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0348975

In a zebrafish model of seizures, on characterizing a series of CBD analogues
In Vivo Characterization of Synthetic Cannabidiol Analogs for Seizure Suppression in Zebrafish
https://pubs.acs.org/doi/full/10.1021/acschemneuro.6c00205

In a mouse model of inflammation due to obesity, the terpene citral (from lemongrass) caused painkilling partially via the CB2 receptor
Citral exerts a more pronounced antinociceptive effect in obese adult male C57BL/6J mice mediated through the CB2 receptor
https://www.sciencedirect.com/science/article/pii/S0014299926003766

In a mouse model of atherosclerosis (hardened arteries), the gut bacteria Akkermansia muciniphila helped via the CB2 receptor
Akkermansia muciniphila attenuates high-fat diet-induced atherosclerosis through regulation of the endocannabinoid system
https://www.sciencedirect.com/science/article/pii/S1756464626001751

In a mouse model of depression, the combination of gastrodin (a component of orchids popular in Traditional Chinese Medicine) & transcranial magnetic stimulation helped partially via the gut-brain axis & the endocannabinoid system
Synergistic antidepressant effects of gastrodin combined with repetitive transcranial magnetic stimulation: Mediation by the gut-brain axis and endocannabinoid system
https://www.sciencedirect.com/science/article/abs/pii/S0022395626002566
One more for a list of exotic treatments that help via the endocannabinoid system…

🆕 Novel Studies 🆕

(a grab bag section for cool & new stuff)

For the toxicity of a vaping device vs a pre-roll, this white paper found pre-rolls to have a much higher toxicity (exceeding the EPA threshold by 2 orders of magnitude), though the vapes had markedly higher levels of nickel (via this post by author Arnaud Dumas de Rauly) (#ingestion)
Comparative Toxicity of Emissions: Electronic Cannabis Delivery Systems (ECDS) versus Combustion of Un-Infused Cannabis Pre-Rolls. A Screening-Level Hazard Characterization White Paper
https://ecdsvspreroll.com/

For the metabolites produced when CBD is burned, 86 compounds were detected, with several known to have adverse health effects
Detection and identification of small-molecule cracking products formed on pyrolysis of cannabidiol part 1: C3–C10 compounds
https://link.springer.com/article/10.1186/s42238-026-00442-8

In a tobacco plant, on genetically inserting the full CBD biosynthesis pathway of 128 genes from 5 cannabinoid synthesis families
Reconstitution of cannabidiol biosynthesis pathway in Nicotiana benthaminana through multigene synthetic engineering
http://www.sciencedirect.com/science/article/pii/S0926669026007065

In today’s edition of ‘who approved this research?’…
For cannabis use, public health data showed the levels were higher in states that legalized
Cannabis Legalization and Emerging Adult Risk: A Cross-Sectional Analysis
https://www.ahajournals.org/doi/abs/10.1161/cir.153.suppl_1.TU138
And for young adults taking a survey, changing out the word “marijuana” for “cannabis” did not change their responses
Assessing Reliability of a Change in Survey Item Terminology from “Marijuana” to “Cannabis” Among a Sample of U.S. Adolescents and Young Adults
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2650106

Lex’s roundup of fav newsletters:
#Canna: Marijuana Moment, Cannabis Law Report, Cultivated, Cannabis Musings (oy vey), Talking Joints Memo, Sticky Bits, Highly Objective, Cannabitch, Indigenous Cannabis Industry Association, Dr. Peter Grinspoon, Doctor Approved, Medical Marijuana Memory Blog (by Dame Alice O’Leary Randall)
#DrugWar: InSight Crime, Marshall Project, Students for Sensible Drug Policy
#HarmReduction: Filter, Drug Data Decoded, International Drug Policy Consortium, National Harm Reduction Coalition, Canadian Drug Policy Coalition
#Psychoactives: Psychedelic Alpha, Ecstatic Integration, ICEERS, Substance, The Microdose

📰 US Headlines & Fav Articles

The TSA clarified that they’re not looking for cannabis, but it’s up to the individual security officer if an illegal substance is found
https://www.tsa.gov/travel/security-screening/whatcanibring/items/medical-marijuana
While the DOT clarified that truckers & pilots still can’t use medical cannabis despite the new reclassification to Schedule III
https://www.marijuanamoment.net/truckers-and-pilots-still-cant-use-medical-marijuana-even-though-trump-reclassified-it-transportation-department-says/
And the US Army reminded soldiers that all cannabis products are banned, even CBD lotions
https://www.marijuanamoment.net/army-reminds-soldiers-of-zero-tolerance-marijuana-policy-warning-that-even-cbd-lotion-remains-banned/

On cannabis rescheduling, a legal & ethical analysis through a Biblical Worldview
Cannabis Reclassification: Economic, Legal, and Ethical Implications of Executive Order 12866
https://digitalcommons.liberty.edu/cgi/viewcontent.cgi?article=1266&context=hsgppconference
I have to say, though this isn’t the lens I use to view the world, they had some fairly reasonable conclusions concerning the benefits of medical cannabis versus the dangers of normalized substance use, though they did lose points with me for quoting professional POS Jerry Falwell.

In Colorado, Wanda James sued her fellow CU regents for their longest-ever sanction against her after she opposed a cannabis public health campaign that she deemed racist
https://www.westword.com/news/colorado-university-regent-sues-peers-sanctions-40888152/

🌐 International Updates 🌐

In France, new strict food regulations will limit CBD edible levels to ~2 mg per day
https://cannabislaw.report/france-to-restrict-cbd-edibles-under-stricter-eu-novel-food-enforcement/
Meanwhile, the country is emerging as Europe’s dominant exporter of industrial hemp raw materials
https://hemptoday.net/france-emerges-as-europes-dominant-exporter-of-industrial-hemp-raw-materials/
“Until the 2021-22 marketing year, French hemp exports were almost nonexistent, totaling just 415 metric tons, mainly to Canada. But export opportunities opened sharply beginning in 2022-23, with shipments rising to 47,950 metric tons in 2023-24 and holding at 47,765 metric tons in 2024-25. About 72% of exports now go to EU member states.”

In Nepal, a review of their current cannabis laws & its traditional uses
Current Nepalese Legislative Framework, Pharmacology and Chemistry of Medicinal Cannabis: A Comprehensive Review
https://journals.sagepub.com/doi/pdf/10.1177/1934578X261451344

In Nigeria, a review of skoochies, an “unregulated concoction that commonly mixes codeine-based cough syrups, cannabis extracts, alcohol, tramadol, and sometimes benzodiazepines”
Skoochies as a Multi-Substance Psychoactive Cocktail: Pharmacological and Public Health Implications
https://www.researchgate.net/profile/Olamide-Fasakin-2/publication/404291399_Skoochies_as_a_Multi-Substance_Psychoactive_Cocktail_and_Its_Review_Article_Pharmacological_and_Public_Health_Implications/links/69f1ecd5db00ec75d02e2b85/Skoochies-as-a-Multi-Substance-Psychoactive-Cocktail-and-Its-Review-Article-Pharmacological-and-Public-Health-Implications.pdf

⚖️ Business, Laws & Education ⚖️

The first ever bankruptcy protection for a cannabis MSO
https://cannabislaw.report/delaware-court-grants-cannabist-first-ever-chapter-15-bankruptcy-protection-for-a-cannabis-mso/

For labeling inaccuracy & contamination, this thesis project tested 70 products & found 30% not containing a listed cannabinoid, 74% containing a cannabinoid not listed, residual solvents in more than half the samples & microbial contamination on almost every flower product
Labelling Inaccuracy and Contamination in Commercial Cannabis Products: A Chemical and Microbiological Surveillance
https://scholarscompass.vcu.edu/frsc_projects/142/

After 5 years of legalization in Ontario, an analysis of the products available & the trend of decreasing prices
An update on cannabis products, cannabinoid content, plant type, and prices five years after legalization in Ontario, Canada
https://pubmed.ncbi.nlm.nih.gov/42093040/

In cannabis retailers in 5 US cities, an analysis of their noncompliance for youth-appeal marketing, health claims, discounts & required warning signage
Cannabis retailers’ marketing practices and compliance with state regulations: A 2025 point-of-sale audit in 5 U.S. Cities
https://www.sciencedirect.com/science/article/pii/S0306460326001437

In Florida gun laws, a federal lawsuit on medical cannabis users prohibited from owning firearms
High-Caliber Tensions: Implications of Florida’s Medical Marijuana Program on the Right to Keep and Bear Arms
https://repository.law.miami.edu/cgi/viewcontent.cgi?article=4821&context=umlr

In hospitality establishments, on the willingness to pay for cannabis edibles
The Roles of Motivation, Opportunity, and Ability on Willingness-To-Pay for Cannabis-Infused Edibles in Hospitality Establishments and the Mediating Role of Involvement
https://www.researchgate.net/publication/402269463_The_Roles_of_Motivation_Opportunity_and_Ability_on_Willingness-To-Pay_for_Cannabis-Infused_Edibles_in_Hospitality_Establishments_and_the_Mediating_Role_of_Involvement

🚗 Driving 🚗

For driving, the combination of cannabis edibles & alcohol produced greater impairment & subjective intoxication than either substance alone, but cannabis by itself or with a small amount of alcohol did not significantly impair performance
Impact of Cannabis Edibles Combined With Alcohol on Driving, Field Sobriety Performance, and Subjective Effects: A Within-Participant Crossover Trial
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2848548

For driving & problematic cannabis use, a survey found that those with likely cannabis dependence reported greater psychological symptoms & driving inattention
Beyond just intoxication: An exploration of the potential links between problematic cannabis use, self-reported psychological dysfunction, and subjective driving capabilities
https://www.sciencedirect.com/science/article/pii/S0022437526000733

For driving performance in medical cannabis users with chronic pain, they had better reaction times in a divided attention simulation, but the overall findings were tainted by a lot of simulator sickness
Medical Marijuana Initiation and Simulated Driving Performance Among Mid-to-Late-Life Adults With Chronic Pain: Prospective Observational Feasibility Cohort Study With Matched Controls
https://formative.jmir.org/2026/1/e79735

🚓 The War on Drugs 🚓

The Inspector General of the Pentagon said it will review the “established targeting framework” for the dozens of attacks on alleged drug-smuggling boats, though it will not examine their legality
https://apnews.com/article/boat-strike-pentagon-inspector-general-evaluation-targeting-72e9006c57aa2c695744402934e4ca66

In Vietnam, four people sentenced to death for narcotics trafficking & heavy sentences for the remaining 12 defendants
https://vietnamnews.vn/society/1781332/four-sentenced-to-death-in-major-laos-viet-nam-drug-trafficking-bust.html
And a female DJ sentenced to death for narcotics trafficking
https://vietnamnews.vn/society/1780931/a-female-dj-sentenced-to-death-for-drug-trafficking.html

In Singapore, a 73-year-old’s death sentence appeal for a charge of carrying 43 g of heroin was dismissed because the judge concluded the defendant did know he was carrying drugs
https://mothership.sg/2026/05/man-heroin-trafficking-death-sentence-appeal-dismissed/

In California, a man charged with tax evasion of $7.1M for allegedly hiding $80M in contraband cannabis sales
https://cannabislaw.report/a-southern-california-man-pin-hsien-hsu-has-been-arrested-and-charged-with-evading-7-1-million-in-state-sales-tax-after-allegedly-hiding-80-million-in-contraband-marijuana-sales/
In law enforcement, that’s what they call the Al Capone method…

In India, the bust of several cartels has pushed local narcotics labs underground
https://ommcomnews.com/india-news/indias-drug-war-pushes-cartels-underground-sparks-rise-of-local-narco-labs/
And their first large-scale bust of Captagon (a synthetic amphetamine-based stimulant, popular in the Middle East)
https://argusenglish.in/national/operation-ragepill-how-indias-first-captagon-bust-signals-a-new-narco-terror-transit-threat
And the home minister announced that the country will be drug-free by 2047
https://timesofindia.indiatimes.com/india/india-will-wipe-out-narcos-be-drug-free-by-2047-shah/articleshow/131129372.cms

In the Philippines, 11 narcotics officers were dismissed for kidnapping & murdering 2 local cockfight enthusiasts
https://www.philstar.com/nation/2026/05/02/2525009/napolcom-dismisses-11-drug-war-cops

In South Africa, a bust of 2 Audis led to “17 compressed dagga bales”, with one of the arrested parties being a constable
https://www.cannabiz-africa.com/blog/da-calls-for-ipid-to-investigate-saps-involvement-in-illicit-cannabis-dealing

WoD Research

For the synthesis of illegal drugs, an analysis from Dutch court rulings on how it’s done
A crime script analysis of synthetic drug production
https://link.springer.com/article/10.1007/s12117-026-09596-6

In Bolivia, on the torture & state violence practiced under their drug policy
https://idpc.net/publications/2026/4/forbidden-voices-torture-and-cruel-inhuman-or-degrading-treatment-under-drug-policy-in-bolivia

In Ontario, cannabis legalization did not substantially change trends for drug-related offenses
Impact of cannabis legalization on drug possession offences among people who experience incarceration in Ontario, Canada
https://www.sciencedirect.com/science/article/pii/S095539592600157X

For online drug trafficking, a comparative analysis of Iran vs Switzerland, with the latter adopting a 4-pillar policy of prevention, treatment, harm reduction & law enforcement
A Comparative Analysis of Cyber Police Capacity in Preventing Online Drug Trafficking in Iran and Switzerland
https://csiw.qom.ac.ir/article_4382_en.html?lang=en

On drug trafficking in Mexico, a book on routes through protected environmental areas
Drug Trafficking and Protected Areas in Mexico
https://link.springer.com/book/10.1007/978-3-032-18218-0

For the drug trafficking over the Myanmar/NE India border, interviews with prisoners on the size & nature of the drug smuggling
Facets of Cross-Border Drug Trafficking in Manipur–Myanmar Borderland
https://usiofindia.org/pdf/USI_Journal_Jan_March_2026.pdf

In Myanmar, on their opium boom after World War II
Opium Pathways: Mountains, Mules and Resource Extraction in Shan State, Myanmar
https://onlinelibrary.wiley.com/doi/abs/10.1111/dech.70066

For narco-outlaw figures in Colombia & Central America, a thesis project on their literary representation
Where Anomie Meets Neoliberalism: Narco and Organized Crime Outlaw Figures in Post-1989 Colombian and Central American Northern Triangle Literature
https://www.proquest.com/openview/ed91f9e33231d104014c18c1fe4ea658/1

🛡️ Harm Reduction News 🛡️

In Ireland, approval for their first supervised drug injection facility to become permanent
https://www.thejournal.ie/irelands-first-supervised-drug-injection-facility-to-become-permanent-7045976-May2026/

The National Association of EMS Physicians & their position statement on the importance of offering opioid use disorder treatments for harm reduction
The Role of Emergency Medical Services in Addressing Opioid Use Disorder—A Position Statement and Resource Document of NAEMSP
https://www.tandfonline.com/doi/pdf/10.1080/10903127.2026.2668009

An editorial against designating fentanyl as a weapon of mass destruction
Fentanyl Is Not a WMD
https://link.springer.com/article/10.1007/s11606-026-10499-z

Harm Reduction Research

For overdose prevention centers in the US, a retrospective model found that increased availability could have saved thousands of lives & tens of billions of dollars
County by county estimation of possible deaths averted, infections averted, and cost savings of overdose prevention centers in the United States from July 2019-June 2025
https://pmc.ncbi.nlm.nih.gov/articles/PMC13131708/

In Canadian safer supply programs, on their rise & fall
The Rise and Fall of Safer Supply Programs in Canada
https://jamanetwork.com/journals/jama-health-forum/fullarticle/2848523

For safer supply programs, interviews on the disruptions & harm from their discontinuation
A continuum of disconnection: the impacts of safer supply program closures on continuity of care, transition, and total loss of service access
https://link.springer.com/article/10.1186/s12954-026-01469-z

At Insite (Vancouver’s supervised consumption site), a case report of prescribed fentanyl leading to the reduced usage of unregulated drugs, more site engagement & increased retention on oral opioid agonist therapy
Safe Supply at Insite, North America’s First Supervised Consumption Site: A Case Report of Reduced Harms From the Toxic Drug Supply in a Client Prescribed Powdered Fentanyl Alternative
https://onlinelibrary.wiley.com/doi/abs/10.1111/dar.70175

In people who smoke crack in England, interviews on the importance of safer smoking materials
Innovation, respiration and drug paraphernalia policy: a mixed methods study of crack pipe practice and respiratory harm in England
https://link.springer.com/article/10.1186/s12954-026-01470-6

On nyaope (the highly addictive street drug of South Africa), a chemical profiling found multiple opiates & adulterants
Chemical Profiling of Nyaope and Its Public Health Implications
https://www.mdpi.com/2305-6304/14/5/410

For the opioid crisis, a legal analysis of it as unjust enrichment for the pharmaceutical companies
The Opioid Crisis as Unjust Enrichment
https://scholarship.law.unc.edu/cgi/viewcontent.cgi?article=7079&context=nclr

For the opioid crisis, a thesis project comparing the public health approaches of the United States versus Portugal
Catching Up with Death The Opioid Crisis in the United States vs. Portugal’s Public Health Approach
https://spiral.lynn.edu/cgi/viewcontent.cgi?article=1220&context=studentpubs

🍄 Psychoactives, Psychedelics & Plant Medicines 🍄

In Amanita muscaria mushrooms (the red-capped kind used by Siberian shamans), a review of clinical evidence & self-experimentation
Amanita muscaria in the evolving novel psychoactive substances landscape - toxicological risks and clinical implications: a narrative review
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1838212/abstract

Psychedelics & MDMA

In people with a traumatic brain injury, ibogaine microdosing caused progressive neurological recovery, with 2 of the 3 cases achieving complete symptom remission (#ibogainebrain)
Clinical Improvement Following an Integrative Iboga Microdosing Protocol in Post-Concussive and Hypoxic Brain Injury Syndromes: A Case Series
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1840956/abstract

For psilocybin mushrooms in the Sierra Mazateca, on their extractive disappearance
From Agents to Earth Beings: Sacred Mushrooms and New Extractivism in the Sierra Mazateca
https://brill.com/view/journals/wo/30/1/article-p61_4.xml

For the wounded healer narrative in psychedelic therapists, a thesis project of interviews
Alchemy of the Wounded Healer: A Narrative Inquiry into the Lived Experiences of Psychedelic Use Among Licensed Healthcare Professionals Across Spiritual, Personal, and Professional Domains
https://www.proquest.com/openview/1844cffae9d9a86fc247d0cbf157112c/1

In people with psychosis, case reports of potential benefits from psychedelics
Variability in outcomes and subjective effects of psychedelic use in psychotic populations: Case-based evidence from naturalistic settings
https://www.sciencedirect.com/science/article/pii/S2950484826000147

In young people who had difficult psychedelic experiences, interviews on their experiences & harm reduction strategies
Adolescents’ and Young Adults’ Integration Processes for Extended Difficulties Following Challenging Psychedelic Experiences: A Qualitative Investigation
https://assets-eu.researchsquare.com/files/rs-9668424/v1/8ead3bf5-9495-4369-abf9-983acdb615a5.pdf

In people taking ayahuasca, their resilience predicted their response to challenging experiences as well as meaning-making in psychospiritual outcomes
Baseline Resilience as a Predictor of Ayahuasca Acute Effects and Moderator of the Relationship between Acute Effects and Psychospiritual Outcomes
https://journals.sagepub.com/doi/pdf/10.1177/28314425261448756

In a comparison of ayahuasca users vs meditators, the meditators had a higher score on their “‘Delusion of Me’ (DoM) index, a unidimensional self-report measure comprising three domains: acceptance, decentering, and non-attachment”
Investigating Hypo-Egoic Features: Ayahuasca’s Psychedelic Path Versus Meditation’s Mindful Journey
https://pubmed.ncbi.nlm.nih.gov/42083787/

For the effects of psychedelics on authoritarian attitudes, a meta-analysis across 3 studies found no significant changes
Effects of psychedelic use on authoritarian attitudes revisited
https://journals.sagepub.com/doi/full/10.1177/02698811261443677

In people with cancer, interviews found them open to the idea of psychedelic therapy
Anything that helps: cancer patient and carer perspectives on psychedelic-assisted therapy
https://pubmed.ncbi.nlm.nih.gov/42080906/

For anorexia, on the potential models with psilocybin
Psilocybin-Assisted Therapy for Adolescent Anorexia Nervosa: Clinical Considerations and Emerging Models of Care
https://link.springer.com/article/10.1007/s11920-026-01679-z

A new book on psychedelics & the development of our religious practices
The Role of Psychedelics in the Development of Human Religious Practices: The Innate Human Quest for Transcendence
https://link.springer.com/chapter/10.1007/978-3-032-20214-7_4

For psychedelic therapy, on the synergy with music
The Harmonious Dance: A Narrative Review on Psychedelics and Music in Therapeutic Settings
https://pubmed.ncbi.nlm.nih.gov/42083530/

For ibogaine & psychiatric disorders, a review of the 3 trials
From monotherapy to sequential models: An updated scoping review on ibogaine’s role in treatment for psychiatric disorders
https://journals.sagepub.com/doi/abs/10.1177/02698811261443674

In a mouse model of fibromyalgia, low-dose LSD improved pain & mood
A New Use for an Old Compound: Microdosing LSD to Reduce Fibromyalgia Symptoms
https://drugrepocentral.scienceopen.com/hosted-document?doi=10.14293/iDR.26.001SA

In older mice, this thesis project found that psilocybin caused a shift in their gut microbiome
Psilocybin Induces Shifts in Gut Microbial Composition of Aged Mice
https://www.proquest.com/openview/a1416a58462672ef3ce5918dc824fe1c/1

Ketamine

For new ketamine analogues, a report from the French addictovigilance network
Emerging new psychoactive ketamine analogues: patterns of use and health risks identified by the French Addictovigilance Network
https://www.sciencedirect.com/science/article/pii/S0955395926001787

In young people using ketamine, a review of their problems with urinary tract damage & addiction
Ketamine: an emerging epidemic in young people - implications for primary care
https://pubmed.ncbi.nlm.nih.gov/42134962/

For postpartum depression, a meta-analysis of ketamine found therapeutic promise & minimal transfer into breastmilk
Ketamine and esketamine for the prevention of postpartum depression: A systematic review and network meta-analysis, with an integrated evidence synthesis
https://www.sciencedirect.com/science/article/pii/S0165178126002829

In adults with suicidal ideation, 4 weeks of ketamine injections showed beneficial effects
Suicidal Ideation Effectiveness and Safety Outcomes from the Ketamine for Adult Depression Study (KADS)
https://www.tandfonline.com/doi/full/10.1080/13811118.2026.2669779

In people using ketamine for depression, brain scans found non-responders had higher brain network density
Changes in depression symptom network structure following ketamine treatment in treatment-resistant depression
https://www.sciencedirect.com/science/article/pii/S0165032726008165

In people taking ketamine for depression, AI analysis of brain scans found that greater gray matter volume in frontal regions predicted treatment response, while greater volume of the cerebellum (brain region of voluntary movement, motor learning & balance) predicted non-response
Structural imaging predictors of ketamine response in treatment-resistant depression: a machine learning approach
https://www.nature.com/articles/s41398-026-04085-4

For people with tobacco use disorder, a single dose of ketamine had little impact on their cravings or withdrawals
Effects of a Single Sub-Anesthetic Dose of Ketamine in Tobacco Use Disorder: An Active-Placebo, Randomized Crossover Study
https://www.mdpi.com/2076-3425/16/5/496

For helping with speech in adolescent autism, a hypothesis of using ketamine infusions
Rewiring Speech in Autism: A Ketamine Infusion Hypothesis
https://esmed.org/MRA/mra/article/view/7464

For depression & suicidal symptoms, a meta-analysis of 26 trials with ketamine found it helped acutely, though longer-term outcomes were not well established
Ketamine Infusions and Rapid Reduction of Suicidal and Depressive Symptoms in Major Depressive Episode: A Systematic Review and Meta-Analysis
https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2848531

In people with depression & bipolar disorder, a review of 26 ketamine studies found it helped with sleep & circadian rhythm
Effects of ketamine on sleep and circadian rhythmicity in major depressive disorder and bipolar disorder: A systematic review
https://www.sciencedirect.com/science/article/pii/S0165032726007676

For treatment-resistant depression, a review of 21 studies on ketamine
Cognitive effects of intravenous Ketamine in treatment-resistant depression: A systematic review
https://pubmed.ncbi.nlm.nih.gov/42100880/

For ketamine, a review of how it interacts with glutamate (the brain’s most common excitatory neurotransmitter)
Ketamine and the glutamatergic system: A systematic review of NMDA receptor modulation
https://publicacoes.cespu.pt/index.php/sl/article/view/484

Kratom

For kratom, a review of its alkaloids & their properties
A review on Mitragyna alkaloids pharmacology, biosynthesis and biotechnological insights
https://www.sciencedirect.com/science/article/pii/S1687157X26000545

For kratom & pigment problems, a case report of kratom use for lower back pain leading to blue-gray pigmentation of the face, neck & hands
Photodistributed Hyperpigmentation in a Chronic Kratom User: Histologic and Elemental Characterization
https://onlinelibrary.wiley.com/doi/abs/10.1111/cup.70126

Kava

For kava, a survey on consumption patterns found reported effects to include reduced anxiety, improved mood & sedation, with only 12% reporting it to be habit-forming & more than half finding it to be a substitute for alcohol
Kava (Piper methysticum) consumption patterns and conceptualizations: results from an online survey
https://link.springer.com/article/10.1186/s13011-026-00728-3

Cathinones

A storytelling essay on the cathinone 3-MMC
On 3-MMC: A Cathinone I Have Come to Know and Love
https://philpapers.org/rec/OSTOMA-2

🍃 The Plant & its Products 🍃

🌱 Growing 🌱

For cultivating medical cannabis, on the feasibility of using reclaimed municipal water
Feasibility of medicinal cannabis cultivation in outdoor conditions using municipal reclaimed water
https://link.springer.com/article/10.1186/s42238-026-00433-9

For hemp growing in Turkey, interviews with farmers on the effects of efficiency on their carbon balance
Assessing the relationship between technical efficiency and net carbon balance in industrial hemp production systems in Turkey
https://acsess.onlinelibrary.wiley.com/doi/abs/10.1002/jeq2.70192

For planting density in the southeastern United States, higher planting density reduced stem height & diameter but improved bast fiber yield
Plant population effects on fiber hemp growth and yield in Southeastern United States
https://acsess.onlinelibrary.wiley.com/doi/pdf/10.1002/agj2.70427

For cannabis fertilization, on the interplay of phosphate availability & nitrogen balance
Phosphate availability shapes source–sink dynamics and nitrogen balance in dual-purpose hemp (Cannabis sativa L.): Insights from physiological and transcriptomic analyses
https://www.sciencedirect.com/science/article/pii/S0926669026007727

In salt-stressed hemp, phosphorus-solubilizing bacteria & phosphorus-enriched biochar enhance growth & yield
Phosphorus-solubilizing bacteria and phosphorus-enriched biochar enhance growth, cannabinoid content, and essential oil yield in salt-stressed hemp (Cannabis sativa L.)
https://www.sciencedirect.com/science/article/abs/pii/S0168945226002360

In different cannabis cultivars, on the effects of methyl jasmonate & insecticides on yield
Interactive Effects of Methyl Jasmonate, Cultivar, and Insecticide Treatments on Agronomic and Phytochemical Traits of Cannabis sativa L.
https://journals.ashs.org/view/journals/hortsci/61/5/article-p900.xml

For hemp cultivars in Puerto Rico, on the agronomy for the best yield
Flower yield, cannabinoid and terpene content of selected hemp cultivars
https://revistas.upr.edu/index.php/jaupr/article/view/23101

In waterlogged hemp, on the effects on growth & yield
Industrial hemp response to waterlogging stress: Influence of duration and growth stage on physiological performance and yield
https://assets-eu.researchsquare.com/files/rs-9546420/v1/05746efd-2a1c-498b-8db1-d3d425703909.pdf

For cannabis with a dual-stress event (nutrient lockout & growth chamber failure), on trying to create a recovery protocol
Physiological Recovery and Morphological Reversion of Cannabis sativa Following Environmental Stress and Nutrient Lock Out
https://minds.wisconsin.edu/handle/1793/97340

On hemp fiber degumming with a novel natural thermal-cooling cycle
A novel natural thermal-cooling cycle treatment for hemp fibers degumming
https://www.sciencedirect.com/science/article/abs/pii/S0959652626010280

In 5 cultivars of northern Morocco, an analysis of their morphological traits
Morphological traits characterization of five Cannabis sativa L. cultivars from the Rif Mountains, northern Morocco
https://link.springer.com/article/10.1007/s42535-026-01715-6

For a decarboxylated extract of Gorilla Glue, on its profile & the stability of its CBD
Gorilla Glue Cannabis Extracts: Cannabinoid Profiling and CBD Hydrolysis Investigation
https://publicacoes.cespu.pt/index.php/sl/article/view/495

Profiling the Z-face cultivar
Cannabinoid Profiling of Z-Face Cannabis Cultivar Extracts
https://publicacoes.cespu.pt/index.php/sl/article/view/493

In a genetic analysis of hemp, a new control region found for flowering time
Identification of a major QTL and candidate gene for photoperiodic flowering in industrial hemp via BSA-seq and fine mapping
https://www.researchsquare.com/article/rs-9403686/v1

On dehydrating & oxidizing cannabis leaves with a hybrid solar-electric method
Hybrid solar-electric thermal dehydration and oxidation of Cannabis sativa L. leaves. Prospecting of CBD, THC and CBN concentration
https://scielo.iics.una.py/scielo.php?pid=S2409-87522026000100073&script=sci_abstract&tlng=en

⚙️ Extracting, Analyzing & Formulating ⚙️

During the processing of cannabis flower, on the changing cannabinoid profile during decarboxylation, extraction & purification
Exploring cannabinoid profile changes during cannabis flower decarboxylation, extraction, and purification
https://publicacoes.cespu.pt/index.php/sl/article/view/506

On cannabinoid extraction via ohmic heating (aka Joule heating, a technique of heating material by passing an electric current through it)
Evaluation of Cannabinoid Extraction from Cannabis Flowers Using Ohmic Heating
https://publicacoes.cespu.pt/index.php/sl/article/view/468

For creating hemp extracts that are protein-rich but cannabinoid-free, on combining solvent-free ultrasound & microwave-assisted extraction
Production of Protein-Rich and Cannabinoid-Free Extracts from Industrial Hemp by Combined Solvent-Free Ultrasound- and Microwave-Assisted Extraction
https://pubs.acs.org/doi/full/10.1021/acsfoodscitech.6c00123

For detecting CBD in beverages, on using surface-enhanced infrared absorption
Reduced Graphene Oxide for Surface-Enhanced Infrared Absorption Detection of Cannabidiol in Beverages
https://pubs.acs.org/doi/abs/10.1021/acsanm.6c00649

On analyzing neutral cannabinoid levels using HPLC-DAD
A sustainable approach to analyzing neutral cannabinoids using HPLC-DAD
https://publicacoes.cespu.pt/index.php/sl/article/view/505

For analyzing cannabinoid levels, on a liquid chromatography photo-diode array (LC–PDA) method
Innovative Framework for Blinded Evaluation of Methods: Application to Cannabinoid Quantification in Hemp
https://watermark02.silverchair.com/qsag039.pdf

On optimizing terpene profiling using a GC-MS
GC-MS Terpene Profiling in Cannabis extracts: Method Optimization and Analytical Validation
https://publicacoes.cespu.pt/index.php/sl/article/view/491

For CBD nanosystems, a patent review
Unraveling approaches for cannabidiol delivery nanosystems: A patent review
https://www.sciencedirect.com/science/article/pii/S0753332226005457

On creating complexes of cannabinoids & terpenes in 3D-printed films
3D-Printed Mucoadhesive Hydrogel Buccal Films Based on HPMC and Carbopol Bioinks Incorporating Cyclodextrin–Cannabinoid Complexes and Terpenes
https://www.mdpi.com/2310-2861/12/5/386

On crystallizing CBD into crystals & microgels for better bioavailability
Hydrophilic carriers for encapsulation of hydrophobic drug cannabidiol: Vaterite CaCO3 crystals and multilayer microgels made of sustainable polymers
https://www.sciencedirect.com/science/article/pii/S2772950826002049

🍞 Food & Nutrition 🍞

For gluten-free baked goods, on optimizing hemp seed oil extraction
Optimization of hemp seed oil extraction and functional testing of its by-product in gluten-free baked goods
https://www.scielo.br/j/bjft/a/vVkyLxcp55ysdzPwnXTXCvR/

For bottled water infused with CBD, on the efficacy of an aseptic bottling process
Refreshing Innovation: Quality, Safety, and Chemistry of CBD-Infused Bottled Water
https://www.preprints.org/frontend/manuscript/cc6305871ce3da70dde0da164ef99389/download_pub

For hempseed proteins, a review on their use as a food ingredient
Hempseed proteins as novel food ingredients: a review
https://link.springer.com/article/10.1007/s00217-026-05128-2

For hemp seeds, on an ethanol extraction & the extract’s efficacy for inhibiting nitric oxide
Establishment of Ethanol Extraction Conditions for Hemp Seed and Evaluation of Nitric Oxide Inhibitory Activity of Its Extract
https://www.e-jkfn.org/journal/view.html?doi=10.3746/jkfn.2026.55.4.311

For hemp protein isolate extracted by an alkaline method, an analysis of its water holding & fat absorption capacity
Investigating the Water Holding Capacity and Fat Absorption Capacity of Hemp Protein Isolate (Cannabis sativa L.) Extracted by Alkaline Method
https://fsct.modares.ac.ir/article_28581_en.html

From hemp seeds, on the properties of the novel polysaccharide HSP-Ia
Structural characterization and in vitro evaluation of the hypolipidemic activity of the HSP-Ia, a bioactive polysaccharide derived from hemp (Cannabis sativa L.) seeds
https://www.sciencedirect.com/science/article/abs/pii/S0144861726005564

In feeding hemp to sheep, their digestibility decreased for dry matter, organic matter & crude protein
Δ9-tetrahydrocannabinol and cannabidiol resist rumen microbial metabolism but impair feed digestibility and alter VFA profiles
https://connectsci.au/an/article/doi/10.1071/AN25332/272633/9-tetrahydrocannabinol-and-cannabidiol-resist

🏗️ Industrial Uses & Fiber 🏗️

For cannabis removing forever chemicals from the soil, a thesis project on improving uptake via microbial inoculations
IMPROVING CANNABIS SATIVA’S PHYTOREMEDIATION CAPABILITIES OF FOREVER CHEMICALS THROUGH MICROBIAL INOCULATIONS
https://commons.nmu.edu/theses/921/

For removing copper from water, on using a hemp hydrogel
Synthesis and Characterization of Hemp Oil-Impregnated Chitosan-Polyvinyl Alcohol Hydrogels for Synergistic Copper (II) Ions Removal from Water
https://www.preprints.org/frontend/manuscript/56d90d6dc6d9a03abf239038dbc05b87/download_pub

For brake pads, on combining hemp, flax, bamboo & coconut shell
Investigation of the Usability of Agricultural and Biomass Wastes in Brake Pad Composites
https://assets-eu.researchsquare.com/files/rs-9618636/v1/c36052ac-c1c6-4194-bd96-4b3fffb114e9.pdf

For automotive interiors, on a biocomposites based on hemp seed oil
Hemp seed oil-based bio-composites as a sustainable alternative for automotive interior applications
https://link.springer.com/article/10.1007/s13726-026-01647-7

For vinyl ester composites (often used in airplanes), on improving properties with hemp & agave fiber
Mechanical and drilling studies on interfacial adhesion improved hemp and agave hybrid fibre & biosilica reinforced vinyl ester composite
https://journals.sagepub.com/doi/abs/10.1177/00219983261449598

On reinforcing polyethylene with hemp to improve wear resistance
Studies on Wear Behavior of Hemp Fiber-Reinforced High-Density Polyethylene (HDPE) Composites Using Taber Abrasion Test
https://www.taylorfrancis.com/chapters/edit/10.1201/9781003471844-5/studies-wear-behavior-hemp-fiber-reinforced-high-density-polyethylene-hdpe-composites-using-taber-abrasion-test-kondusamy-samsudeensadham-sriram-sriguhan-sudeep

In polymer composites with hemp fiber, on predicting roughness
Integrating AWJ Process Parameters with Ensemble Learning Techniques (RF & XGBoost) for Accurate Surface Roughness Prediction in Hemp Fibre Polymer Composites
https://ieeexplore.ieee.org/abstract/document/11508321

For creating a plastic composite with pineapple leaf & hemp fibers
Enhanced polylactic acid composites reinforced with pineapple leaf and hemp fibers
https://link.springer.com/article/10.1007/s13726-026-01668-2

On a biocomposites film made with starch, agar & hemp fiber
Structure–property relationships in multifunctional starch/agar biocomposite films reinforced with alkaline–peroxide treated hemp fibers for sustainable applications
https://www.sciencedirect.com/science/article/pii/S2468217926000791

For plastic composites, on enhancing its properties with torrefied (roasted) hemp hurd
Hemp hurd torrefaction as an effective strategy to enhance PLA-based composite mechanical and tribological properties
https://www.nature.com/articles/s41598-026-51164-z

On creating a renewable plastic using hemp as a filler
EFFECT OF HEMP FILLER ON THE MECHANICAL AND PHYSICAL PROPERTIES OF PLA/PBAT COMPOSITE FILMS
https://icntcconference.com/wp-content/uploads/2026/05/ICNTC-2026-BOOK-OF-ABSTRACTS.pdf

On improving hemp & jute fiber moisture resistance & mechanical properties with a mild calcium carbonate treatment
A Mild Calcium Carbonate Treatment Improves Moisture Resistance and Mechanical/Interfacial Properties of Jute and Hemp Fibers
https://pubs.acs.org/doi/full/10.1021/acsomega.6c00108

For hemp pressing cake (residue), on comparing combustion via heat & power vs anaerobic bacterial digestion
Energy Valorization of Industrial Hemp Pressing Residues (Cannabis sativa L.) - Combustion, Anaerobic Digestion and LCA using OpenLCA
https://www.epj-conferences.org/articles/epjconf/pdf/2026/25/epjconf_jiama2026_01008.pdf

For hempcrete, a review of advances & techniques
Advancements in hempcrete as a bioresource-based material for sustainable and low-carbon construction
https://link.springer.com/article/10.1007/s41062-026-02665-3

For walls, on using a hemp-clay composite with gum arabic
Assessment of the possibility of using a clay-hemp mixture modified with gum arabic as a wall material
https://www.sciencedirect.com/science/article/pii/S2352710226010570

For sustainable concrete, on the synergy between waste rubber & hemp fibers
Eco-Friendly Structural Solutions: The Synergy of Waste Rubber and Hemp Fibers in Sustainable Concre
https://www.tandfonline.com/doi/pdf/10.1080/15440478.2026.2665745

For hemp lime concrete, an AI to predict its compressive strength
Machine learning prediction of compressive strength of hemp lime concrete for sustainable and resilient infrastructure
https://link.springer.com/content/pdf/10.1007/s43621-026-03262-1_reference.pdf

For composite panels, a lifecycle assessment of their carbon footprint
Cradle-to-gate life cycle assessment of advanced composite panels incorporating CO2-derived multi-walled carbon nanotubes and hemp fiber for sustainable building applications
https://www.sciencedirect.com/science/article/abs/pii/S2352710226011009

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

On delivering cannabinoids to rodents, a review of the many ingestion methods
Pharmacokinetics of Cannabinoids Delivered by Diverse Routes in Rodents
https://karger.com/mca/article-pdf/doi/10.1159/000551979/4535029/000551979.pdf

🏥 Public Health & Bioassays 🏥

In older adults using cannabis edibles, on their reasons for using them for pain, sleep & mental health
Edible Cannabis and Pain, Sleep, and Mental Health Management in Older Adults
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2848773

In a palliative care practice, on lessons for implementing medical cannabis
Cannabis in the Clinic: How to Implement an Embedded Medical Cannabis Program in an Academic Palliative Care Practice
https://www.sciencedirect.com/science/article/abs/pii/S0885392426003015

In a genetic analysis of Moroccan people, on their novel variant of the CB1 receptor
Genomic and structural analysis of the endocannabinoid system in Moroccans: A novel CNR1 variant (V392A) impairs CB1 receptor stability
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0347606

In Iranian healthcare students, they had therapeutic awareness of medical cannabis but operational hesitancy
Healthcare students’ knowledge and attitude toward medical cannabis: a cross-sectional study in southeastern Iran
https://link.springer.com/article/10.1186/s42238-026-00424-w

In oral fluid, a review on detecting THC with mass spectroscopy
Delta-9-tetrahydrocannabinol detection times using mass spectroscopy in oral fluid: a systematic review using a 5 ng/mL cut-off value
https://link.springer.com/article/10.1007/s00414-026-03805-1

In a breath sampling device, on the factors associated with recovering THC, CBD & CBN
Factors influencing the recovery of Δ9-tetrahydrocannabinol, cannabidiol, and cannabinol from a breath sampling device
https://iopscience.iop.org/article/10.1088/1752-7163/ae6d2c/pdf

In dried blood spots vs drawn blood, a comparison of measuring THC levels & its metabolites
Determination of THC and THC-COOH in Dried Capillary Blood Spots and Comparison to Venous Blood of Recreational Cannabis Consumers in a Pilot Study
https://pubmed.ncbi.nlm.nih.gov/42120005/

In canine urine, on identifying rare cannabinoid metabolites using GC-MS
Characterization of unusual Immunoassay Cross-Reactive Cannabinoid Metabolites in Canine Urine via Gas Chromatography-Mass Spectrometry
https://www.tandfonline.com/doi/pdf/10.1080/15376516.2026.2665315

🧒 Adolescents & Young Adults 🧒

In US adolescents, cannabis use surpassed tobacco use for the first time (#teenuse)
Changing Norms, Changing Risks: Adolescent Cannabis Use Surpasses Tobacco in the United States
https://www.sciencedirect.com/science/article/pii/S0306460326001413

In California adolescents, a survey found they considered cannabis to be less harmful than cigarettes, nicotine vapes & alcohol, with harm perceptions declining with age (unlike for other substances)
Adolescents view cannabis as less harmful than cigarettes, nicotine vapes, and alcohol: Findings from two California school surveys
https://www.sciencedirect.com/science/article/pii/S0376871626001365

In US college students, on their rates of problematic cannabis usage
Operationalizing ASSIST-based indicators to estimate the prevalence and correlates of problematic cannabis involvement among U.S. college students
https://link.springer.com/article/10.1186/s42238-026-00446-4

In college students with high levels of psychological stress, they had higher odds of co-using alcohol & cannabis as well as co-occurring alcohol & cannabis use disorders
Psychological Distress, Unmet Need for Mental Health, and Associated Simultaneous Alcohol and Cannabis Use, and Co-Occurring Disorders Among College Students
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2670608

In young people with problematic cannabis use, interviews on the factors that promoted or hindered their help-seeking
Help-Seeking for Problematic Cannabis Use Among Young People: A Qualitative Study with Professionals and People with Lived Experience
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2670615

In adolescents with cannabis use disorder, motivational interviewing helped reduce their scores & decrease anxiety & depression levels
Effectiveness of Motivational Interviewing in the Treatment of Cannabis Use Disorder Among Adolescents Attending Public Schools
https://ajoeijournal.org/sys/index.php/ajoei/article/view/1137

In Asian & Latinx college students, a younger age of immigration was linked to higher levels of cannabis use
Age at Immigration Linked to Cigarette and Marijuana Use in Asian and Latinx U.S. College Students
https://link.springer.com/article/10.1007/s10903-026-01917-9

Among Andalusian adolescents attending school, those testing positive for COVID were ~ 3x more likely to have used cannabis in the last month
Association between cannabis use and result of COVID-19 testing among scholarised adolescents in Andalusia: A cross-sectional study
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0347098

In youth with pain, public health data showed females having lower levels of the endocannabinoid 2-AG & males with sleep problems having higher levels of anandamide & oleoylethanolamide (though no link between pain levels & endocannabinoids)
427 Endocannabinoids and pain: Exploring sex differences and pain risk factors in youth
https://www.cambridge.org/core/journals/journal-of-clinical-and-translational-science/article/427-endocannabinoids-and-pain-exploring-sex-differences-and-pain-risk-factors-in-youth/A7FD991859ED4FC3BB9131C58BFFECB7

In early adolescence, the endocannabinoid 2-AG & the related lipid 2-oleoylglycerol were associated with behavioral urgency, while anandamide was associated with higher-order functions like perseverance
Associations of endocannabinoid serum concentrations with behavioral impulsivity and substance use in late childhood to early adolescence
https://www.sciencedirect.com/science/article/pii/S0376871626001651

In an adolescent rodent model of THC use, they had elevated levels of anxiety & anhedonia (lack of pleasure)
Adolescent THC-Induced Changes in Behavior and Synaptic Plasticity (Abstract ID: 230707)
https://jpet.aspetjournals.org/article/S0022-3565(26)00205-3/abstract

🧠 The Brain & Neurological Disorders 🧠

In a genetic analysis of people with Alzheimer’s disease, a certain variant of the enzyme FAAH (which breaks down anandamide) preserved brain volume & slowed cognitive decline
Cognitive and Neuroanatomical Effects of Fatty Acid Amide Hydrolase Polymorphism rs324420 in Aging and Alzheimer Disease
https://journals.lww.com/alzheimerjournal/abstract/9900/cognitive_and_neuroanatomical_effects_of_fatty.196.aspx

In rat brain wave scans, on the changes caused by THC & CBD
Effects of THC, CBD, and Their Combination on EEG Dynamics in Rats
https://www.biomed.cas.cz/physiolres/pdf/2026/75_385.pdf

In a mouse model of temporal lobe epilepsy, CBD did not alter seizure activity & THC only increased sedation
Behavioral, electrophysiological, and epigenetic characterization of acute cannabinoid treatment during pilocarpine-induced status epilepticus in mice
https://www.researchsquare.com/article/rs-9569465/v1

In a mouse model of stroke, activating the CB2 receptor decreased damage, loss of neuronal dendrites & hypertrophy of the astroglia (brain immune support cells)
CB2R Agonist Reduces Astroglial and Microglial Reactions and Attenuates the Impact of Focal Cerebral Ischemia in Mice
https://www.researchsquare.com/article/rs-9533706/v1

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

In women with PTSD, positive beliefs about the antianxiety & antidepressant effects of cannabis mediated both their duration of use & psychological outcomes
Cannabis Expectancies as a Mediator in the Relationship Between Cannabis Use and Psychiatric Symptoms in Women With Post-Traumatic Stress Disorder Symptoms
https://assets.cureus.com/uploads/original_article/pdf/442695/20260505-124906-hea997.pdf

In brain scans of people with cannabis use disorder, they had differences in responses to reward functions in certain brain regions (the bilateral insula & right putamen)
Brain reward function in people with moderate-to-severe cannabis use disorder who tried to cut down or quit: an fMRI study
https://www.nature.com/articles/s41598-026-50870-y

In males & females with first-episode psychosis, compared to healthy controls, males had lower CB1 levels while the levels did not differ in females
The Brain Endocannabinoid System is Differentially Regulated in Male and Female Patients with First-Episode Psychosis
https://academic.oup.com/schizophreniabulletin/article/52/3/sbag038/8667491

In the genetics of cannabis use disorder & psychosis, a meta-analysis found overlapping genetic clusters “including intracellular signaling, synaptic function, and neuronal development”
Genetic Pathways Point to the Biology Underlying the Association Between Cannabis Use Disorder and Psychosis
https://www.sciencedirect.com/science/article/pii/S2667174326000248

In brain scans of chronic cannabis users, abstinence was associated with increased levels of the FAAH enzyme (which breaks down anandamide)
PET imaging of FAAH in chronic Cannabis users: longitudinal assessment during short-term abstinence
https://www.nature.com/articles/s41386-026-02438-7

In people with alcohol use disorder, on the factors associated with using cannabis or CBD to help
Cannabis for Harm Reduction: Exploring Mental Health and Other Motivational Factors among Adults at Risk for Alcohol Use Disorder in Florida
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2670620

In people with methamphetamine use disorder (but not opioid use disorder), a certain genetic variant of the enzyme FAAH (which breaks down anandamide) was protective against methamphetamine use disorder
FAAH rs324420 Polymorphism in People With Opioid and Methamphetamine Use Disorders: Psychological Associations
https://pubmed.ncbi.nlm.nih.gov/42135911/

In people with hypersomnolence (an inability to stay awake), cannabis use had little effect on their time to sleep
0719 Much Ado About Nothing? Cannabinoids Do Not Impact Multiple Sleep Latency Test Variables in Suspected Central Disorders of Hypersomnolence Patients
https://academic.oup.com/sleep/article/49/Supplement_1/A320/8674340

In a rat model of ADHD, increasing their levels of the endocannabinoids anandamide & 2-AG lessened defensive behavior in a gendered manner
Acute elevation of anandamide and 2-AG levels modulates defensive behavior in a sex- and strain-dependent manner in an animal model of attention-deficit/hyperactivity disorder
https://www.sciencedirect.com/science/article/pii/S0091305726000559

In a rat model of autism, in males, activating the PPAR-α nuclear receptor (that regulates genetic transcription) increased levels of the endocannabinoid PEA, normalized brain levels of FAAH (the enzyme that breaks down anandamide) & reinstated social behaviors, while in the females, it did not alter their social reward or change their endocannabinoids
PPAR-α activation in a model of autism modulates social reward and endocannabinoid signaling selectively in male rats
https://www.sciencedirect.com/science/article/pii/S0028390826001693

In a mouse model of genetic risk for schizophrenia, activating the CB1 receptor suggested a comorbidity between schizophrenia & cannabis use disorder
Genetic risk for schizophrenia modulates WIN 55,212-2 reward: Evidence from a heterozygous transmembrane domain neuregulin 1 mutant mouse model
https://link.springer.com/article/10.1007/s00213-026-07080-1

In a mouse model of alcohol intoxication, they had increased heart levels of the endocannabinoid anandamide, which mediated dysfunction of the mitochondria (powerhouse of the cell)
Anandamide is a key mediator of alcohol-induced cardiac mitochondrial dysfunction
https://journals.physiology.org/doi/abs/10.1152/physiol.2026.41.S1.2300878

In a rat model of risky decision-making driven by punishment, a thesis project on the role of the cannabinoid receptors
The Role of Cannabinoid Receptors in Punishment-Driven Risky Decision-Making
https://www.proquest.com/openview/951d1ec22bac8c3d1ba9cd7d49949391/1

🦠 The Immune System & Microbial 🦠

In people with HIV, frequent cannabis use was associated with more frequent HIV clinic visits
Longitudinal analysis of symptoms and healthcare utilization among daily cannabis-using persons living with HIV: impact of co-occurring cocaine use
https://link.springer.com/article/10.1186/s42238-026-00443-7

In people with chronic fatigue, cannabinoids had differential effects on the respiration of their mitochondria (powerhouse of the cell)
Cannabinoid-based personalized therapeutic approach to ameliorate mitochondrial function in patients with chronic fatigue (Abstract ID: 269335)
https://jpet.aspetjournals.org/article/S0022-3565(26)01014-1/abstract

In immune cells, on the effects of CBD, cocaine & a drug to activate the CB1 receptor
Cannabidiol and Cocaine Induce Heterogenous and Donor-Dependent Inflammatory Responses in Primary Human Peripheral Immune Cells (Abstract ID: 230793)
https://jpet.aspetjournals.org/article/S0022-3565(26)00235-1/abstract

For extracts of hemp seed, compared to black rice & oat, hemp seed extract had the most significant antimicrobial effects against 3 foodborne pathogens
Comparison of Antioxidant and Antimicrobial Activities of Hemp Seeds, Black Rice, and Oats by Extraction Conditions
https://www.e-jkfn.org/journal/view.html?doi=10.3746/jkfn.2026.55.4.340

🦴 Pain, Musculoskeletal, Inflammation & Surgeries 🦴

In people with spinal cord injuries, higher levels of cannabis use were associated with greater pain interference in mood & life enjoyment but not increased depression severity
Self-reported Opioid and Marijuana Use in a Clinical SCI Setting and Impact on Pain Interference and Depression
https://www.archives-pmr.org/article/S0003-9993(26)00190-5/abstract

In people with fibromyalgia using medical cannabis, it typically took 3 months of tinkering with dosages & formulations to find their best levels
REAL-WORLD TITRATION PATHWAYS AND THERAPEUTIC INTEGRATION OF MEDICAL CANNABIS IN FIBROMYALGIA: INTERIM ANALYSIS OF A REFRACTORY CLINICAL COHORT
https://www.ahr-journal.org/site/article/view/181

For surgery on extra bone growth in the hips, cannabis users had no significant differences in postoperative outcomes
Does preoperative marijuana use influence postoperative outcomes following arthroscopic treatment for femoroacetabular impingement syndrome? A prospective cohort analysis
https://academic.oup.com/jhps/advance-article/doi/10.1093/jhps/hnag020/8667552

In a rat model of pain, the inflammation was mediated by crosstalk between the endocannabinoids & the glucocorticoids in the ventrolateral periaqueductal gray (a brain region for modulating pain as well as defensive & aversive behaviors)
Glucocorticoid–endocannabinoid crosstalk in the ventrolateral periaqueductal gray (vlPAG) promotes pain resolution
https://pmc.ncbi.nlm.nih.gov/articles/PMC13142447/

In mice with growth impairment due to a mutation in pregnancy-associated plasma protein-A2 (PAPPA2), it worked via the cannabinoid receptors for bone formation
Sex-specific hormonal rescue of bone growth in PAPPA2-deficient mice
https://boneandjoint.org.uk/article/10.1302/2046-3758.155.BJR-2025-0563.R1

On drugs to inhibit both the enzymes FAAH (that breaks down anandamide) & soluble epoxide hydrolase (involved in pain & inflammation)
Synthetic and Pharmacological Studies on Polynitrogen-Containing Leads to the Identification of New Dual sEH/FAAH Inhibitors (Abstract ID: 220628)

https://jpet.aspetjournals.rg/article/S0022-3565(26)00319-8/abstract
Pharmacological Investigations and Structure Activity Relationships of Polynitrogen Dual FAAH and sEH Inhibitors (Abstract ID: 229956)
https://jpet.aspetjournals.org/article/S0022-3565(26)00344-7/abstract
Effects of Dual Fatty Acid Amide Hydrolase and Soluble Epoxide Hydrolase Inhibitors on Anxiety-Like Behavior in Rats (Abstract ID: 221485)
https://jpet.aspetjournals.org/article/S0022-3565(26)00354-X/abstract
Dual Inhibition of Fatty Acid Amide Hydrolase and Soluble Epoxide Hydrolase Reduces Inflammatory and Orofacial Pain in Rats (Abstract ID: 221469)
https://jpet.aspetjournals.org/article/S0022-3565(26)00307-1/abstract

❤️ The Heart & Blood ❤️

In adolescents with high blood pressure, they had higher levels of the endocannabinoid 2-AG
Neuropeptides and endocannabinoid system as regulators of blood pressure in adolescents with primary hypertension
https://journals.lww.com/md-journal/fulltext/2026/05010/neuropeptides_and_endocannabinoid_system_as.60.aspx

In a rat model of high blood pressure, CBD lowered a cardiovascular reflex, probably via the GPR18 receptor
Cannabidiol attenuates visceral sympathoexcitatory cardiovascular responses through GPR18 receptors in rats
https://journals.physiology.org/doi/abs/10.1152/physiol.2026.41.S1.2297969

In a rat model of high blood pressure, blocking both the CB1 receptor & the nitric oxide-synthesizing enzyme helped to lower blood pressure
Chronic simultaneous inducible nitric oxide synthase (iNOS) and peripheral cannabinoid CB1 receptors blockade ameliorates pulmonary hypertension in monocrotaline-induced rat model
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1831802/abstract

🩸 The Liver, Drug Interactions & Cannabinoid Metabolism 🩸

In liver cells, on the different effects of CBD & CBG on the AhR/CYP1A pathway
Cannabigerol and cannabidiol differ in their ability to affect the AhR/CYP1A pathway in vitro
https://www.sciencedirect.com/science/article/pii/S0278691526002309

🍽️ The Guts, Nutrition & the Microbiome 🍽️

For obesity, a hypothesis on CB1 receptors in the liver being a key driver
Is Hepatic Cannabinoid 1 Receptor a Key Driver of Obesity? Implications of the Weight-Reducing Efficacy of the Hepatotropic Inverse Agonist TM38837
https://pubmed.ncbi.nlm.nih.gov/42135988/

In a rat model of metabolic syndrome, inhibition of the FAAH enzyme (which breaks down anandamide) reversed memory impairments but did not improve spatial memory performance
Chronic intranasal URB597 treatment reverts short-term memory deficits in a rat model of metabolic syndrome
https://www.sciencedirect.com/science/article/pii/S0024320526002547

In a mouse model of Crohn’s disease, the CB2 receptor was found to promote the immune system’s T cells to go to the guts & increase inflammation
CB2R promotes T cell gut homing and exacerbates ileitis in a murine Crohn’s model
https://academic.oup.com/ibdjournal/advance-article/doi/10.1093/ibd/izag066/8678283

🎗️ Cancer & Chemotherapy 🎗️

In someone with advanced cancer, on the long bureaucracy to allow her to use medical cannabis
Rolling It Out: Operationalizing Inpatient Use of Medical Cannabis for Symptom Management in Advanced Cancer
https://www.sciencedirect.com/science/article/abs/pii/S0885392426003349

For combining cannabinoids with chemotherapy cancer treatment, a meta-analysis of the preclinical evidence found a significant effect in a number of tumor types
Antitumor Activity of Cannabinoids and Their Interaction with Chemotherapy: A Systematic Review and Meta-Analysis of Preclinical Evidence
https://www.mdpi.com/1424-8247/19/5/768

For CBD & cancer, this review found it caused antitumor effects via a variety of mechanisms
Cannabidiol-Induced Tumor Cell Death: Molecular Mechanisms and Translational Perspectives in Cancer
https://www.tandfonline.com/doi/pdf/10.2147/DDDT.S597740

In a mouse model of neuropathy from chemotherapy, the synthetic cannabinoid KLS-13019 combined with the treatment paclitaxel reduced tumor size while significantly lessening neuropathy
KLS‑13019, A Synthetic Cannabidiol Analogue Reverses Chemotherapy-Induced Peripheral Neuropathy while Preserving Chemotherapeutic Efficacy in Tumor-Bearing Models (Abstract ID: 273334)
https://jpet.aspetjournals.org/article/S0022-3565(26)01040-2/abstract

In melanoma cells, CBD-loaded nanoparticles reduced cell viability & caused antitumor activity
Lipid nanoparticle-encapsulated cannabidiol enhances selective cytotoxicity in melanoma cells
https://publicacoes.cespu.pt/index.php/sl/article/view/470

In canine breast cancer cells, they had overexpression of endocannabinoid-related receptors & CBD downregulated key inflammatory genes
Modulation of the endocannabinoid system reduces inflammatory signalling in canine mammary carcinoma cells
https://bvajournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/vro2.70034

In colorectal cancer cells, cannabis stem extracts caused cytotoxicity
Phytochemical profiling, selective cytotoxicity, and FoldX-assisted molecular interaction analysis of Cannabis sativa L. stem extract
https://www.sciencedirect.com/science/article/abs/pii/S0254629926002450

In breast cancer cells, resistance to the treatment trastuzumab is driven by the CB2 receptor, suggesting it as a target to overcome resistance
Cannabinoid CB2 receptor drives trastuzumab resistance and predicts durable anti-HER2 response
https://www.nature.com/articles/s41388-026-03814-9

💊 Synthetic Cannabinoids & Hemp-Derived Cannabinoids 💊

For derivatives of the synthetic cannabinoid JWH-018, on their effects on body temperature, painkilling, locomotor activity & catalepsy
In vivo evaluation of synthetic cannabinoid JWH018 derivatives as potential new psychoactive substances
https://www.nature.com/articles/s41598-026-51639-z_reference.pdf

In mice, on co-administering a benzodiazepine with the synthetic cannabinoid 5F-APINACA
Behavioral and Pharmacokinetic Implications of Synthetic Cannabinoid Receptor Agonist and Benzodiazepine Co-Administration in C57BL/6 Mice (Abstract ID: 221452)
https://jpet.aspetjournals.org/article/S0022-3565(26)00476-3/abstract

In synthetic cannabinoids, those with a valinamide or tert-leucinamide head moiety had activity at the 5-HT2A serotonin (psychedelic ) receptor
5‐HT2A receptor agonism by tert‐leucinamide and valinamide synthetic cannabinoids: In vitro and in vivo evidence
https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bph.70457

For screening synthetic cannabinoids, on an optical method
Analyte-templated aggregate remodeling for broad-spectrum visual screening of synthetic cannabinoids
https://www.sciencedirect.com/science/article/abs/pii/S0039914026006168

🔬 Biochemical Discoveries & Research Tools 🔬

In tissue cultures, how CBDA interacts with the translation initiation factor EIF2A
The study of the molecular mechanism of action of cannabidiol in 2D and 3D in vitro cell models reveals new insights about the translation factor EIF2A
https://www.researchgate.net/publication/404624106_The_study_of_the_molecular_mechanism_of_action_of_cannabidiol_in_2D_and_3D_in_vitro_cell_models_reveals_new_insights_about_the_translation_factor_EIF2A

For this CB1 receptor & the phosphorylation of ERK, it seems to be driven by downstream G proteins
G proteins rather than arrestin drive ERK phosphorylation downstream of the cannabinoid CB1 receptor
https://www.authorea.com/doi/full/10.22541/authorea.15003148/v1

For the structures of the CB1 & CB2 receptors, a review on how these alter the binding of ligands
Structural Insights into Cannabinoid Receptors CB1 and CB2: Determinants of Ligand Selectivity
https://www.frontiersin.org/journals/chemical-biology/articles/10.3389/fchbi.2026.1830007/abstract

For the CB2 receptor, a structure analysis on positive allosteric regulation (binding to a side site to alter binding strength at the main binding site)
Structural basis for positive allosteric regulation of CB2 receptor
https://www.nature.com/articles/s41467-026-72923-6_reference.pdf

On the behavioral effects from dual inhibitors of the FAAH enzyme (which breaks down anandamide) & the enzyme MAGL (which breaks down the endocannabinoid 2-AG)
Dual Fatty Acid Amide Hydrolase (FAAH) and Monoacylglycerol Lipase (MGL) Inhibitors Produce Ratio-Dependent Cannabinoid Activity In Vivo (Abstract ID: 225992)
https://jpet.aspetjournals.org/article/S0022-3565(26)00477-5/abstract

On new inhibitors of the MAGL enzyme (which breaks down 2-AG)
Covalent Inhibitors of Monoacylglycerol Lipase Induce Conformational Changes and Proteasomal Degradation
https://pubs.acs.org/doi/abs/10.1021/jacs.5c22859

For creating novel endocannabinoid analogs, a thesis project on their design, synthesis & biological evaluation
Design, synthesis and biological evaluation of novel endocannabinoid analogs
https://repository.library.northeastern.edu/files/neu:ms35v287s

Thanks.
- lex

PS: For this week’s heavenly singing from South Africa, the album ‘Shaka Zulu’ by Ladysmith Black Mambazo. This 1987 album was produced by Paul Simon after the men’s choral group Ladysmith Black Mambazo sang on his album Graceland. First founded in 1960 by Joseph Shabalala, he began with a group of relatives who grew up singing together on the farm & named them Ladysmith Black Mambazo (the name of his hometown + black for the black oxen, strongest of all farm animals + the Zulu word for a chopping axe, a symbol of the group’s vocal ability to clear the path to success). They wrote songs of hope & peace, protesting against South Africa’s system of apartheid. Later, when Nelson Mandela was released from prison in 1990, he said that he listened to their music to help him through & upon his release, declared them to be South African cultural ambassadors to the world. When Mandela won the Nobel Peace Prize, Ladysmith Black Mambazo accompanying him to the ceremony.
In their first years, they were not known outside their hometown, but after winning choral competitions from Durban to Johannesburg, they were eventually banned from competitions so that other groups would have a chance to win. Their first album came out in 1973 & it was the first record from a South African group of Black musicians to go gold. When Shabalala converted to Christianity, new religious material entered the group’s repertoire, especially Methodist hymns. The group became so popular that in 1981, the apartheid government even allowed them the travel to Germany as part of a South African music festival. Then Paul Simon came to South Africa in 1985 to collaborate with African musicians & he flew Ladysmith Black Mambazo to London for the recording of ‘Graceland’. He later brought them to New York City to perform on Saturday Night Live to promote the album. After this, their popularity never waned & they’ve been touring at least 6 months of the year ever since.

This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.
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Stigma, more anesthesia, CUD, CHS & the War on Drugs

Lex Pelger WhiteWhaleCreations — Mon, 18 May 2026 13:31:50 GMT

Cannabinoids & The People,
or; Drugs & Drug Wars

🌟 This Week 🌟

THC & CBD for rheumatological conditions
Stigma still a problem for medical cannabis use, especially in older folks
Cannabis users need more anesthesia
In college athletes, cannabis linked to slower reaction times
Cannabis Use Disorder Week: 9 studies
For CHS, growing your own is actually a risk factor
Preclinical: CBD for neuropathic pain, depression, PTSD & lung injury
Psychedelics: first documented traditional use of psilocybin in Africa + 3 on psychedelics for autism
Ketamine: 3 on the bladder problems
War on Drugs: attack on innocent Ecuadorian fishermen + CIA-linked assassinations in Mexico +lots of good reporting
Harm reduction: US overdoses down everywhere except the West + CDC should abandon the term “EVALI”

[numbers for C&P#187: ~7.5k words, ~20 minutes reading time, 152 papers]

Hello everyone,
Welcome to the 187^th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news + the War on Drugs, harm reduction & other psychoactives. Support this work with a paid subscription or by buying me a coffee.

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Canna-edu videos sponsored by the National Cannabis Study (join & get paid $100 to talk about your use of our favorite plant)

Prenatal Cannabis Exposure (on this video that took me a lot of time, almost 17 views!)

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Folk Tale Collections & One Poetry

And as always, at the bottom is the album of the week: Big Boy Crudup, Father of Rock & Roll (?!)

💖 Ways to support this work 💖

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📣 A request to spread the word 📣

This newsletter only spreads by word of mouth, so please share to friends & colleagues.

🍃 BEST OF CANNABINOID SCIENCE 🍃

(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)

⚕️ Clinical ⚕️

For people with a rheumatological condition, those using THC/CBD-balanced products had the highest positive impact scores, with the most benefit seen from dried cannabis or edibles
Perceived Impacts and Predictors of Cannabis Products used by Rheumatology Patients in Alberta: A Multivariable Analysis of Cross-sectional Survey Data
https://acrjournals.onlinelibrary.wiley.com/doi/abs/10.1002/acr.80071

For schizophrenia & CBD, a meta-analysis of 5 trials found small improvements to positive symptoms (hallucinations, delusions, disorganized speech, etc) & general health, but no effects on negative symptoms (lack of motivation, flattened affect, social withdrawal, etc)
Cannabidiol for the treatment of positive and negative symptoms in schizophrenia spectrum disorders: a systematic review and meta-analysis
https://link.springer.com/article/10.1007/s00406-026-02249-3

For anesthesia in cannabis users, a meta-analysis of 7 studies found they required more propofol as well as moderately increased levels of opioids
Anesthetic Requirements in Chronic Cannabis Users: A Systematic Review and Meta-Analysis
https://www.scivisionpub.com/pdfs/anesthetic-requirements-in-chronic-cannabis-users-a-systematic-review-and-meta-analysis-4174.pdf

In someone with a glioblastoma (most aggressive brain cancer), a case report of radio-chemotherapy combined with CBD leading to 25 months of stability
Unexpected long survival of a patient with glioblastoma treated with bevacizumab and cannabidiol
https://jcimcr.org/pdfs/JCIMCR-v7-4002.pdf

For brain aneurysms, THC use was not associated with more risk or more severe clinical presentations
Recreational substance use and aneurysmal subarachnoid hemorrhage: differential effects of alcohol and THC
https://link.springer.com/article/10.1007/s10143-026-04295-w

For Dravet syndrome (a rare pediatric epilepsy), a comparison found that stiripentol worked as well as fenfluramine & caused a greater seizure reduction than CBD
Comparative Efficacy and Safety of Stiripentol, Cannabidiol, and Fenfluramine as First-Line Add-On Therapies for the Treatment of Seizures in Dravet Syndrome: A Network Meta-Analysis Study
https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0046-1822865

In college athletes, cannabis use was linked to ~20% slower reaction speed, which was partially reversed with a year of abstinence
Cognitive Performance Recovery Following Marijuana Cessation in NCAA Division I Athletes
https://www.frontiersin.org/journals/sports-and-active-living/articles/10.3389/fspor.2026.1821656/abstract

For stigma in cannabis, a review of 25 studies on how “ageism, legal ambiguity, and provider bias, leads to nondisclosure of cannabis use”
Stigma, Including Anticipated Stigma, and Cannabis Use Disclosure Among Older Adults in Health Care Settings: An Integrative Review
https://journals.healio.com/doi/abs/10.3928/19404921-20260416-01
And an analysis of stigma causing harm when cannabis is being used as a medicine
Taboo or Treatment? Cannabis as Medicine in the Face of Stigma
https://dialogues.rutgers.edu/images/Journals_PDF/dialogues-issue20_accessible-compressed.pdf#page=124

For dronabinol (pharmaceutical THC) prescribed by Medicare, its usage decreased slightly from 2014 to 2019, with the most common areas of medicine being internal, family, oncology & infectious diseases
Geographical Disparities and Medical Specialty Differences in Dronabinol Prescribing in Medicare
https://utppublishing.com/doi/pdf/10.3138/guthrie-2025-0006
Patients tend to dislike dronabinol because isolated THC, without anything else to modulate it, is often said to either feel like nothing, or like “getting kicked in the face by a horse”.

In Connemara ponies taking CBD for 3 weeks, on the metabolic effects (moderate changes to insulin dynamics) & how it moves through their system (a slow elimination)
Metabolic effects and pharmacokinetics of oral cannabidiol (CBD) in Connemara ponies following 21 days of treatment
https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1813917/full

Cannabis Use Disorder

For cannabis use disorder, a review on anxiety as a driver of progression
Anxiety as a driver of cannabis use disorder progression: neurobiological, psychological, and clinical pathways
https://www.tandfonline.com/doi/abs/10.1080/14659891.2026.2657872

For cannabis-related disorders (CRD), Medicare data showed adult-use cannabis laws associated with increased rates of CRD diagnoses & claims
The Impact of Recreational Cannabis Laws on Cannabis-Related Disorders in the US Medicare Population
https://ajph.aphapublications.org/doi/abs/10.2105/AJPH.2026.308522

For cannabis use disorder risk, an analysis found 5 distinct classes of users, with the high-risk class increasing during legalization expansion
Latent classes of substance use patterns and cannabis use disorder Risk in U.S. Adults during recreational Legalization expansion (2015–2023)
https://www.sciencedirect.com/science/article/abs/pii/S0306460326001346

For cannabis use disorder, in females, their symptom severity decreased with age & their mental health scores improved, while males did not have these age-related improvements
Sex differences in age-related patterns of cannabis use disorder symptoms and mental health
https://www.tandfonline.com/doi/abs/10.1080/00952990.2026.2650344

In midlife adults, the risks for cannabis use disorder were greatest in those with the highest use frequency, whether medical or nonmedical
Cannabis use disorder risk among midlife adults reporting medical and nonmedical cannabis use, 2019-2024
https://www.sciencedirect.com/science/article/pii/S0376871626001596

For cannabis & lung cancer, public health data found an association between cannabis use disorder & a few types of lung cancer
Association of cannabis use and lung cancer: a retrospective cohort study
https://www.sciencedirect.com/science/article/abs/pii/S0169500226004824

In a Canadian analysis of higher-risk cannabis use, on the rates & ingestion methods across the provinces
Differences in higher-risk cannabis use outcomes across Canadian provinces and territories: A cross-sectional study
https://link.springer.com/article/10.17269/s41997-026-01202-0

For assessing cannabis use disorder, a meta-analysis of 40 studies found a lack of clear evidence for the current diagnostic tools
The psychometric properties of validated tools to assess cannabis use disorder: A systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/42046882/
And unsurprisingly, an evaluation of the ‘Perceived Barriers for Cannabis Reduction and Cessation Scale’ found it to be a reliable measure of perceived barriers for cannabis reduction
Psychometric evaluation of the perceived barriers to cannabis reduction and cessation scale
https://www.sciencedirect.com/science/article/abs/pii/S0306460326001383

⚠️ Harms ⚠️

In frequent cannabis users, the morning after using cannabis, they had no cognitive impairment, but worse memory
Cognitive performance and subjective effects the morning after last use of smoked cannabis by adults who use cannabis frequently: An observational study
https://static1.squarespace.com/static/5fa2eabb04edcf45a65121de/t/69d3eef9406c4e6cd92805ab/1775496960488/cognitive+performance+the+next+day.pdf

For the accidental ingestion of THC by children, an editorial against the automatic reporting of cases to child protective services (CPS)
Things We Do for No Reason™: Reporting every child who ingests tetrahydrocannabinol to child protective services
https://shmpublications.onlinelibrary.wiley.com/doi/abs/10.1002/jhm.70334
“Yet, ingestions of other household products, like cleaners with more capacity to harm children than THC, do not automatically trigger reporting. CPS investigations can cause harm. Instead of automatic reporting, hospitalists should consider whether the child’s caregiver took reasonable steps to prevent unintentional ingestion and recognizes the dangers of child-friendly THC packaging. Hospital providers must explore the circumstances of each ingestion to determine which should trigger mandatory reporting.”

In children, on differentiating between cannabinoid hyperemesis & cyclic vomiting syndrome
Cannabinoid Hyperemesis Versus Cyclic Vomiting Syndrome in Children Presenting to the Emergency Department
https://scholarlyworks.corewellhealth.org/corewellhealth_west_research_posters/120/

For cannabinoid hyperemesis syndrome, higher risk was associated with an older age of first cannabis use, more frequent use of edibles & concentrates, riskier cannabis use patterns, growing your own cannabis, using cannabis for headaches/migraines or nausea/vomiting & experiencing bipolar disorder or psychosis/dissociative identity disorder
Cannabinoid hyperemesis syndrome prevalence and risk factors in the U.S.
https://www.sciencedirect.com/science/article/abs/pii/S0955395926001593

For cannabinoid hyperemesis syndrome, a case report & advice on diagnosis & care in the emergency room
Cannabis Hyperemesis Syndrome: Diagnosis and Care in the Emergency Setting
https://www.ovid.com/jnls/aenjournal/fulltext/10.1097/tme.0000000000000625~cannabis-hyperemesis-syndrome-diagnosis-and-care-in-the

For cannabinoid hyperemesis syndrome, a case report of a 13-year-old with significant weight loss whose diagnosis was initially superior mesenteric artery syndrome (compression in the GI tract)
Cannabinoid Hyperemesis Syndrome Mimicking Superior Mesenteric Artery Syndrome: A Case of Delayed Diagnosis in an Adolescent
https://www.xiahepublishing.com/2994-8754/JTG-2026-00001

In youth affected by psychosis, those in early psychosis care had a “strikingly high rate of cannabis use”
Prevalence of cannabis use in psychosis-affected youth: Insights from an Ontario-based early intervention cohort
https://www.tandfonline.com/doi/pdf/10.1080/15332640.2026.2657003
As always, is cannabis use driving the psychosis or is it a DIY treatment that they found?
(my recent video on this complex subject)

For brain imaging in substance-induced psychosis, a review found cannabis use linked to alterations in the cerebellum (brain region of voluntary movement, motor learning & balance) & cingulate cortex (a brain region of social cognition, emotional processing & learning)
Structural Neuroimaging in Substance-Induced Psychosis
https://link.springer.com/article/10.1007/s11920-026-01678-0

In youth with prenatal tobacco-cannabis co-exposure, public health data found they had more early school-age physical aggression, while postnatal cannabis exposure was linked to more relational aggression, with maternal sensitivity being protective against both types of aggression
Prenatal and Postnatal Exposure to Tobacco and Cannabis and Child Aggression at Early School Age: Role of Early Maternal Sensitivity
https://link.springer.com/article/10.1007/s10578-026-02020-8

In male rats exposed to THC as adolescents, they had reduced body weight during exposure & later, reduced novel object recognition & increased vulnerability to anxiety
Long-term effects of adolescent THC exposure on anxiety-like behavior and cognitive function in male rats
https://link.springer.com/article/10.1007/s00213-026-07067-y

In a mouse model of prenatal CBD or THC exposure, CBD-exposed females had impaired risk appraisal, CBD-exposed males had synaptic rigidity, while both THC- & CBD-exposed offspring had lessened long-term depression (reducing the strength of a synapse)
Prenatal Cannabidiol and THC Exposure Induce Sex-Specific Executive Dysfunction via Divergent Pathological Rewiring of the Adult Medial Prefrontal Cortex
https://assets-eu.researchsquare.com/files/rs-9428628/v1/ad21fcdc-3eb0-46dd-809b-53ce0e2b2e4d.pdf

In a mouse model of prenatal CBD exposure, it’s linked to preterm birth because it activates the ion channel PIEZO1, a regulator of contractions
Cannabidiol modulates PIEZO1 activity to regulate uterine contractility and pregnancy outcome
https://langtaosha.org.cn/lts/en/preprint/view/194

In a mouse model of prenatal exposure to both stress & THC, they had disrupted maternal caregiving & the offspring as adolescents had reduced motivated behavior & increased anxiety-like behavior, with female offspring most affected by THC for self-care & social behavior
Concurrent maternal stress and THC exposure alters maternal regulation and downstream adolescent corticolimbic programs
https://www.nature.com/articles/s41398-026-04049-8_reference.pdf

📑 Reviews 📑

In menopausal women, a review on the potential of cannabis for sleep disturbances, genitourinary symptoms & hormonal changes
Medicinal Cannabis and Sleep Improvement in Menopausal Women: Integrating Nocturia, Genitourinary Syndrome of Menopause, and Endocannabinoid Regulation
https://asrjs.com/pdfs/medicinal-cannabis-and-sleep-improvement-in-menopausal-women-integrating-nocturia-genitourinary-syndrome-of-menopause-and-endocannabinoid-regulation-312.pdf

For neuropsychiatric disorders, a review of targeting the endocannabinoid system (with great charts)
The Endocannabinoid System in Neuropsychiatric Disorders: Mechanisms, Dysregulation and Therapeutic Potential
https://www.mdpi.com/2227-9059/14/5/968

For depression, on the evidence of cannabis helping via reductions of neuroinflammation in the brain & hyperactivity in the hypothalamic–pituitary–adrenal (HPA) axis
Interplay between the HPA Axis and Inflammation as Mechanisms Therapeutic Targets of Cannabis sativa in Depression
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1801474/abstract

For Alzheimer’s disease, a review of the data for CBD & THC
Cannabinoids in Alzheimer’s disease: animal–human evidence and clinical pharmacology challenges
https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2026.1833021/abstract

For cannabis & chronic pain, a Polish review of the evidence
Practical aspects of using cannabis in the treatment of chronic pain and the current situation in Poland: a narrative review
https://journals.viamedica.pl/palliative_medicine_in_practice/article/view/111341

In children with cancer, a review of drug interactions with cannabinoids found the highest risk to be for cyclophosphamide, doxorubicin, etoposide, ifosfamide, irinotecan, vinblastine & vincristine while potential synergies were found with temozolomide, vinblastine, vinorelbine & irinotecan (and if you’re confused as to how some of those drugs are on both lists, you are not alone)
An Overview of Cannabinoid Interactions With Common Pediatric Antineoplastic Agents
https://pubmed.ncbi.nlm.nih.gov/42057496/

For dogs with cancer, a review of the antitumor effects of CBD
Antitumor Effects (Potential) of Cannabidiol (CBD) in Canine Oncology: A Systematic Review
https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1800410/abstract

🐁 Preclinical 🐁

In a rat model of neuropathic pain with depression & anxiety, CBD reduced anxiety, depression & pain-related behaviors via the CB1 & a serotonin receptor in the anterior insular cortex (integrator of sensory & emotional aspects of pain)
Cannabidiol in the Anterior Insular Cortex Attenuates Chronic Neuropathic Pain and Comorbid Anxiety- and Depression-Like Behaviors: Involvement of CB1 and 5-HT1A Receptor Signaling
https://assets-eu.researchsquare.com/files/rs-9226782/v1/73b6fdeb-ee2d-4035-a5b0-29a6fc00f8ea.pdf

In a female rat model of depression, CBD caused increased freezing times, higher cortisol levels & improved memory-related performance
Effects of Cannabidiol on Behavior and Oxidative Stress in a Rat Model of Depression Under Chronic Stress
https://www.mdpi.com/2039-4713/16/3/73

In a mouse model of PTSD, CBD shifted their genes towards non-stressed levels
Cannabidiol modulates spontaneous recovery through distinct and conserved transcriptomic signatures in mPFC subregions
https://www.nature.com/articles/s42003-026-10111-4_reference.pdf

In a rat model of lung injury due to blood loss, CBD reduced oxidative stress, suppressed inflammation & inhibited apoptosis (programmed cellular suicide)
Cannabidiol attenuates lung ischemia-reperfusion injury by modulating RIPK1/RIPK3-mediated necroptosis and HIF-1α/VEGF signaling
https://ijbms.mums.ac.ir/article_27571.html

In rats, the combination of cannabis & aerobic exercise modulated cardiac inflammation
Cannabis supplementation combined with aerobic exercise is associated with modulation of AKT, PI3K, and inflammatory gene expression in cardiac tissue and blood of fatty liver rats
https://www.sciencedirect.com/science/article/abs/pii/S2452014426000841

In mice taking CBG, this thesis project found no significant impact on motor coordination or fatigue
Use of a Cannabigerol and Cannabidiol Formulation on Motor Coordination and Fatigue in the C57BL/6 Mouse
https://harvest.usask.ca/server/api/core/bitstreams/93f716bb-abd9-48cf-b449-4d449ba19ca1/content

In rats taking hemp seed oil for 10 weeks, they developed mild fatty liver disease
Immunohistochemical analysis and distribution of lymphocytes and Kupffer cells in the liver of rats with long-term experimental use of hemp seed oil
https://pubmed.ncbi.nlm.nih.gov/42048501/

In a genetic expression analysis, CBD, CBC, CBG & CBN were predicted to alter metabolism & have some benefits for the heart but adverse effects for the brain, with potential liver toxicity from CBC, CBN & (more strongly) CBD, while CBG protected the liver
Transcriptomic comparison on the mechanism of action of four major constituent cannabinoids in hemp extract
https://link.springer.com/article/10.1186/s42238-026-00432-w

For HIV in human astrocytes (the brain’s most common support cell), this thesis project found that THC & CBD lowered inflammation
Δ9-Tetrahydrocannabinol and Cannabidiol Diminish Primary Human Monocyte-Astrocyte Inflammatory Interactions: Implications for Chronic HIV
https://www.proquest.com/openview/4ad57a4697459f031a09ce57d8e50b76/1

🆕 Novel Studies 🆕

(a grab bag section for cool & new stuff)

In an analysis of the public comments on cannabis rescheduling, ~29% supported it, ~7% opposed it &~63% said it didn’t go far enough, with the supporters being motivated most by therapeutic benefits & economic impacts, while the opposers were concerned with public health risks, addiction & underage use
Characterizing public comments via Regulations.gov in response to proposed cannabis rescheduling in the United States
https://pubmed.ncbi.nlm.nih.gov/42029003/

Lex’s roundup of fav newsletters:
#Canna: Marijuana Moment, Cannabis Law Report, Cultivated, Cannabis Musings (oy vey), Talking Joints Memo, Sticky Bits, Highly Objective, Cannabitch, Indigenous Cannabis Industry Association, Dr. Peter Grinspoon, Doctor Approved, Medical Marijuana Memory Blog (by Dame Alice O’Leary Randall)
#DrugWar: InSight Crime, Marshall Project, Students for Sensible Drug Policy
#HarmReduction: Filter, Drug Data Decoded, International Drug Policy Consortium, National Harm Reduction Coalition, Canadian Drug Policy Coalition
#Psychoactives: Psychedelic Alpha, Ecstatic Integration, ICEERS, Substance, The Microdose

📰 US Headlines & Fav Articles

The DEA shares two Canadian cannabis horror stories (a murder + a God complex) that point to the rare but real mental health dangers of high levels of THC
https://www.justthinktwice.gov/news-statistics/2024/06/12/descent-cannabis-induced-psychosis-one-edmonton-familys-horror

In Georgia’s medical cannabis program, lupus added as a qualifying condition & vapes as an ingestion method (but not smoking)
https://www.marijuanamoment.net/georgia-governor-signs-bill-to-expand-medical-marijuana-access-by-allowing-vaping-and-adding-new-qualifying-conditions/
As always, I believe that the uses of medical cannabis should be left to healthcare practitioners & not to lawmakers. And for so many patients, smoking & its fast relief is their ideal ingestion method.

In New Jersey, a court said a police officer can’t be fired for off-duty cannabis use
https://cannabislaw.report/new-jersey-court-rules-police-officers-cant-be-fired-for-off-duty-cannabis-use/

In Connecticut, lawmakers reinstated a cap on THC levels at 35%
https://www.marijuanamoment.net/connecticut-lawmakers-pass-bill-to-reinstate-thc-limits-for-marijuana-flower/

The Grand Ole Opry named Señorita as its official THC beverage
https://www.globenewswire.com/news-release/2026/05/14/3294752/0/en/se%C3%B1orita-named-official-thc-beverage-partner-of-opry-entertainment-group-venues.html
In celebration, here is a performance by the Cannabis Crusader Willie Nelson at the Grand Ole Opry in 1965, looking very clean cut.
This one is also in tribute to my grandfather “Pap” who introduced me to Willie & who, for someone of his generation, was surprisingly sympathetic to cannabis.

History Corner: 1975: a sentence of 12 years in prison for a 19-year-old selling 11 grams of grass
https://boingboing.net/2026/05/15/19-year-old-got-12-years-for-selling-5-of-pot-in-1975.html

🌐 International Updates 🌐

In Greece, the government moves to ban hemp flowers despite an advisory board saying that this contradicts EU law
https://businessofcannabis.com/greece-moves-to-ban-hemp-flower-sales-despite-government-advisory-body-warning-of-conflict-with-eu-law/

In a German draft of a new law, the government would end public healthcare coverage of cannabis flowers (but not extracts or pharmaceutical cannabinoids)
https://cannabislaw.report/germany-update-rate-stabilization-act-end-of-cannabis-flowers-as-a-reimbursable-service-planned/
And a federal court placed further restrictions on cannabis telemedicine
https://cannabislaw.report/germany-judiciary-restricts-practices-of-telemedicine-platforms-for-cannabis/

In the UK, the first available cannabis suppositories were made by Curaleaf
https://cannabislaw.report/good-shit-curaleaf-laboratories-becomes-first-uk-manufacturer-of-medical-cannabis-suppositories/

In Zambia, medical cannabis to be integrated into the public health system
https://cannabislaw.report/zambia-major-policy-shift-new-controlling-body-aims-to-integrate-cannabis-into-public-health-system/

In Pakistan, the government met with tribal leaders to formalize cannabis cultivation
https://cannabislaw.report/pakistan-govt-engages-tribal-elders-to-formalise-cannabis-cultivation/

In Bolivia, dozens demonstrating for cannabis decrim
https://www.infobae.com/america/agencias/2026/05/02/decenas-se-manifiestan-en-bolivia-a-favor-de-la-despenalizacion-de-la-marihuana/

In Thailand, on the recent see-sawing of cannabis legality
https://www.talkingdrugs.org/from-legalisation-to-limbo-thailands-turbulent-cannabis-industry/
Plus, the Thai press has been reporting on a cannabis fatality due to a heart attack after smoking cannabis
https://www.nationthailand.com/in-focus/40016636

⚖️ Business, Laws & Education ⚖️

In Massachusetts, the greatest cannabis retailer density was in areas of high social vulnerability & low child opportunity
Place-Based Inequities in E-cigarette/Vape and Cannabis Retail Density in Massachusetts: The Role of Child Opportunity and Social Vulnerability
https://www.sciencedirect.com/science/article/abs/pii/S0012369226005982

In a secret buyer program in a Minnesota city, more than half of stores sold hemp-derived THC products to pseudo-underage individuals
More Than Half of Retailers Sold Hemp-Derived THC Products to Underage-Appearing Buyers Despite Age Restrictions
https://www.jsad.com/doi/abs/10.15288/jsad.25-00393

For opportunities in industrial hemp, on using an AI to analyze social media for analyze barriers & possibilities
Exploring barriers and opportunities in industrial hemp through NLP on social media
https://www.sciencedirect.com/science/article/pii/S0040162526001976

🚓 The War on Drugs 🚓

In Ecuador, an account from innocent fishermen wrongly attacked by US drones for suspected narco-trafficking
https://www.theguardian.com/global-development/2026/apr/21/ecuador-us-boat-strike-survivors
Those mother fuckers. When the US patrol boarded the fishing boat after the drone attack with their guns drawn, they first deleted videos of the attack & then stole the crew’s food & beer. The crew were then handcuffed, hooded, held at sea for several days & then taken to El Salvador for questioning before finally being released to immigration authorities. Of course, their boat won’t be replaced & the people behind this extrajudicial attack won’t be held responsible for their wrongs.
“For the crew of the Don Maca, the experience has left lasting trauma. “I get scared in the middle of the night. I can’t sleep well. My ears still hurt,” Palacios said. “I think that’s it for me. I’m done with fishing. Going back out there is impossible. I thought they were going to kill us.” Other crew members have declined to speak publicly, citing fears of reprisal, said Palacios: “They’re afraid someone will kill us for what happened.””

Meanwhile, 120 organizations joined to demand an end to complicity in US extrajudicial killings in the Caribbean
https://elpais.com/us/2026-04-23/mas-de-120-organizaciones-exigen-el-fin-de-la-complicidad-de-terceros-paises-en-las-ejecuciones-extrajudiciales-de-estados-unidos-en-el-caribe.html

In Mexico, on the CIA’s involvement in cartel assassinations & the bind it places on federal officials because of the ban on foreign operatives carrying out missions on Mexican territory
https://edition.cnn.com/2026/05/12/politics/cia-drug-cartels-deadly-operations-mexico

On Guadalupe Fernández Valencia, or “La Patrona”, the highest-ranking woman in the Sinaloa cartel
https://insightcrime.org/news/from-drug-dealer-to-sinaloa-cartels-highest-ranking-woman/

In Poland & central Europe, on how Mexican cartels are setting up meth labs & sending over their cocineros (cooks)
https://balkaninsight.com/2026/04/29/mexican-cartels-are-already-operating-in-poland-and-central-europe/rd/

On how a 30-ton cocaine bust in Spain highlights the highly fragmented supply chain & the rise of West Africa as a major transit hub
https://insightcrime.org/news/what-spains-record-cocaine-bust-says-about-the-drug-trade/

For Tren de Aragua, an analysis of their financial evolution for money laundering
https://insightcrime.org/news/tren-de-aragua-money-laundering-schemes-reveal-factions-ongoing-refinement/

In Brazil, on how influencers are used to launder money for criminal groups (raffles!)
https://insightcrime.org/news/how-influencers-launder-money-for-criminal-groups/
As someone with only 40k followers on TikTok, I guess I’m not big-time enough to have been approached by the cartels, yet.

In Costa Rica, on the first 3 people to be extradited to the US on drug charges, including the former security minister Celso Gamboa Sánchez
https://insightcrime.org/news/meet-the-first-costa-ricans-to-be-extradited-on-drug-charges-to-the-us/

In California, 2 cops got 30 months of prison for continuing to seize cannabis after legalization & then selling it
https://cannabislaw.report/usa-ex-cops-who-posed-as-federal-agents-to-extort-marijuana-get-up-to-30-months-in-prison/

In Australia, a retiree was caught with a truck carrying 110 kg of cannabis (~$720k)
https://cannabislaw.report/australia-nsw-pensioner-accused-of-driving-truck-carrying-a-720k-cannabis-haul/

WoD Research

For the impact of drug legislation on crime reduction, this review found that decriminalization & harm reduction decreased drug possession arrest without increasing violent or property crime, while criminalization & police repression were associated with either no effects or counterproductive effects such as increased violence or recidivism
Impact of Drug Legislation on Crime Reduction: A Systematic Literature Review
https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2026.1806036/abstract

For the push to expand the death penalty to people who deal drugs, a legal & rhetorical analysis from Reagan to Trump
‘Punishing death dealers’: examining claims to expand the death penalty to people who deal drugs
https://www.tandfonline.com/doi/pdf/10.1080/10282580.2026.2663183

In Australia, on Vietnamese crop-sitters & their cannabis syndicates
How Crop-Sitters Unveil the Vietnamese Cannabis Industry in Australia
https://www.taylorfrancis.com/chapters/edit/10.4324/9781003528586-10/crop-sitters-unveil-vietnamese-cannabis-industry-australia-hai-thanh-luong

For cartels, on analyzing them through an entrepreneurial ecosystem framework
Narcos, Inc.: drug cartels and the architecture of entrepreneurial ecosystems
https://link.springer.com/article/10.1007/s12117-026-09591-x

For cybercrime in drug trafficking, a legal analysis of responses at the regional & local levels
Administrative and criminal law analysis of countering cybercrimes in the field of illicit drug trafficking at the regional and local levels
https://www.ashdin.com/articles/administrative-and-criminal-law-analysis-of-countering-cybercrimes-in-the-field-of-illicit-drug-trafficking-at-the-regional-and-lo-1105084.html

In Costa Rica, on mapping the likely routes of narco-trafficking
Mapping the Likely Routes of Narco-trafficking in Costa Rica
https://link.springer.com/article/10.1007/s11067-026-09745-y

In the Malaysian state of Sabah (northern Borneo), on regional drug flows & local economic effects
Framing the Seriousness of Drug Smuggling in Sabah: Enforcement Paradoxes, Borderland Economics, and Regional Drug Flows in Malaysia
https://journal.uitm.edu.my/ojs/index.php/JAS/article/view/11150

An analysis of drug trafficking & the effects on youth
Drug Trafficking, Security Threats, and Impacts on Youth: A Comprehensive Review
https://thesocietyandpeople.com/index.php/tsap/article/view/3

🛡️ Harm Reduction News 🛡️

In the US, overdoses are going down, except in the West (though this data is more messy & localized than I realized)
https://filtermag.org/cdc-overdose-data-west/

On EVALI (E-cigarette, or Vaping, Product Use-Associated Lung Injury) & why the CDC should abandon the term
https://filtermag.org/cdc-abandon-evali/
Basically, this EVALI phenomenon has now been linked distinctly to tainted illicit THC vape cartridges that contained vitamin E acetate, but ever since the confusion of when this story broke, EVALI has become associated with legal nicotine e-cigarettes. This is detrimental to public health because, despite the hand-wringing you might see in some places, vaping nicotine instead of smoking tobacco is a huge public-health win. But misunderstandings around the term EVALI have led to a reduction in nicotine vaping in favor of tobacco smoking. The CDC needs to fix this.

In North Carolina, on Hurricane Helene, harm reduction & what it’s like when people’s needs are taken care of
https://www.wunc.org/2026-05-05/helene-frayed-the-safety-net-for-people-who-use-drugs-the-community-wove-it-back-together

For safer drug supply programs, a bioethical defense
An Ethical Defense of Safer Supply
https://philpapers.org/rec/KRIAED-2

Harm Reduction Research

For addiction care in the US versus the Netherlands, a comparison through an anthropological lens
Governing Addiction: An Anthropological Comparison of Care in the United States and the Netherlands
https://scarab.bates.edu/cgi/viewcontent.cgi?article=1024&context=bjps

For English prisoners about to leave custody, giving them opioid substitution treatment in the month before release reduced later overdoses
https://www.gov.uk/government/statistics/prison-leavers-in-substance-misuse-treatment-4-week-outcomes/prison-leavers-in-substance-misuse-treatment-4-week-outcomes-report

In the Stockholm needle exchange program, despite restrictive regulations, there was a marked reduction in needle sharing
Needle and syringe coverage per injection and factors associated with needle sharing among clients of the Stockholm Needle and Syringe Program, 2013–2023
https://www.sciencedirect.com/science/article/pii/S0955395926001519

In a needle exchange program, adding winged infusion sets (“butterflies”) & larger-volume syringes (“barrels”) increased engagement
Reintroducing Winged Infusion Sets to Needle Syringe Programs: A Case Study in Harm Reduction Equity
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1741947/abstract

On drug sellers’ use of a drug checking service, a British Columbia service found they were used as a preventative measure
Drug sellers’ use of a drug checking service amid the overdose crisis in British Columbia, Canada
https://pubmed.ncbi.nlm.nih.gov/42029063/

For harm reduction vending machines, an analysis of their utility at 2 Pennsylvania sites
“Smart” harm reduction vending machines to improve public health: Evaluating the utilization
https://www.sciencedirect.com/science/article/pii/S2949875926001116

For overdose response hotline operators, interviews on their stressors & fulfillment
“We’re here, and we’re non-judgmental, we’re here to save lives”: stressors and fulfillment among overdose response hotline operators in Canada
https://link.springer.com/article/10.1186/s12954-026-01462-6

For overnight emergency room staff, on empowering them in the treating of opioid use disorders
Midnight medicine: Empowering night shift to treat opioid use disorder (OUD)
https://wmpllc.org/ojs/index.php/jom/article/view/3996

For substance use disorders, a global analysis of their burden
Global substance use disorders burden from 1990 to 2021: post-COVID shifts and widening inequalities
https://pmc.ncbi.nlm.nih.gov/articles/PMC13107084/

🍄 Psychoactives, Psychedelics & Plant Medicines 🍄

In South Africa, the first documented traditional use of psilocybin on the continent
Psilocybin use among Basotho healers and non-healers in southern Africa
https://osf.io/preprints/socarxiv/429dw_v1

On psychedelic trials & the therapists expressing concerns over safety & ethics
https://www.ecstaticintegration.org/p/therapists-on-psychedelic-trials

In the Swiss psychedelic program, on the serious underreporting of harms
https://www.ecstaticintegration.org/p/the-hidden-harms-of-the-swiss-psychedelic

Psychedelics & MDMA

For responsiveness to psychedelic therapy, therapists identified the factors most conducive to positive outcomes to be a strong therapeutic alliance, robust social support, openness, capacity to surrender, secure attachment & belief in an active mode of therapeutic action
Therapist-rated predictors of response to psychedelic-assisted therapy
https://www.nature.com/articles/s44220-026-00642-4

For 5-MeO-DMT, on its use in men’s groups & for transformative leadership sessions
Attunement as Leadership: Council Practice and Low-Dose 5-MeO-DMT as Transdisciplinary Pathways to Transformative Leadership
https://www.tandfonline.com/doi/abs/10.1080/02604027.2026.2659286

In psychedelic use, mystical experiences were associated with greater self-compassion, compassionate love & life satisfaction
Psychedelic Use and Mystical-Type Experiences are Associated With Greater Self-Compassion, Compassionate Love, and Life Satisfaction
https://journals.sagepub.com/doi/abs/10.1177/00221678261442571

For psychedelics, a survey of the processes of ego dissolution & connectedness
Toward enlightenment: Dissolving the ego and expanding the world through mindfulness and psychedelics
https://psycnet.apa.org/record/2027-57942-001

In MDMA for couples therapy, a thesis project interviewing people on the erotic content & relational healing
Sex and Psychedelics: A Phenomenological Inquiry into Erotic Content and Relational Healing in MDMA-Assisted Therapy
https://www.proquest.com/openview/a3b7a94786869eee22af4ddcaf55c2b1/1

For 2C-B vs MDMA & psilocybin, on their physical effects & duration in the body
Acute dose-dependent effects of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) compared with 3,4-methylenedioxymethamphetamine (MDMA) and psilocybin in a double-blind, placebo-controlled study in healthy participants
https://www.nature.com/articles/s41386-026-02428-9

A case report of cardiac arrest after psilocybin use
Talk About a Bad Trip!: Psilocybin Use With Pre-Existing Cardiovascular Conditions, a Case Report
https://scholarlyworks.corewellhealth.org/internal_medicine_confabstract/858/

For the recovery of repressed memories with psychedelics, a review of the (spotty) literature
Evaluating the evidence for repressed memory recovery in psychedelic contexts
https://link.springer.com/article/10.1007/s00213-026-07076-x

For psychedelic medicine, a review of its intertwining with mysticism
Secular Mysticism: Entanglements of Science and Religion in Psychedelic Medicine
https://link.springer.com/article/10.1007/s11013-026-09988-x

For the ayahuasca experience, a review of the brain-body interactions
Brain-body integromics of the ayahuasca experience
https://www.sciencedirect.com/science/article/pii/S0753332226004269

For suicidal ideation & depression, a review of ayahuasca
Ayahuasca Therapy: Possible Reduction of Suicidal Ideation in Treatment-Resistant Depression – A Systematic Review
https://www.tandfonline.com/doi/abs/10.1080/02791072.2026.2661580

For substance use disorders, a review of psychedelics
Epigenetic Mechanisms of Psychedelics in Addiction: Emerging Evidence and Therapeutic Potential
https://media.sciltp.com/articles/2604003691/2604003691.pdf

For adults with autism, a review on the potential benefits of psychedelics
The spectrum of potential benefits and ethical considerations for psychedelic-assisted therapy in autistic adults
https://www.sciencedirect.com/science/article/pii/S2950484826000135
And another
The Ecstasy of Gold in Neurodiversity: Focus on the Use of Psychedelics in Autism Spectrum Disorder
https://www.preprints.org/frontend/manuscript/8a0700c0d1126993e225580221cacdc8/download_pub
And one on the mechanisms used
Serotonergic psychedelics for Autism spectrum disorder: Neurobiological mechanisms and translational prospects
https://www.sciencedirect.com/science/article/pii/S0278584626001144

Ketamine

For people with cancer & existential distress, intranasal ketamine improved all outcome measures
Intranasal Ketamine for Existential Distress in Advanced Cancer
https://www.sciencedirect.com/science/article/abs/pii/S0885392426007657

For the antidepressant effects of ketamine, they were not altered by the current use of SSRIs, SNRIs or antidepressants
Concurrent SSRI, SNRI, or Other Antidepressant Use Not Associated With Differential Outcomes in Ketamine or Esketamine Treatment
https://www.psychiatrist.com/pdf/concurrent-ssri-snri-or-other-antidepressant-use-not-associated-with-differential-outcomes-in-ketamine-or-esketamine-treatment-pdf/

In treatment-resistant depression, brain scans of the changes caused by ketamine
Ketamine-related neural changes in treatment-resistant depression: A multimodal synthesis of fMRI and PET studies
https://www.sciencedirect.com/science/article/abs/pii/S0165032726007433

In treatment-resistant bipolar depression, a case report of ketamine combined with Theta Burst Stimulation (transcranial magnetic stimulation to mimic theta brain waves)
Ketamine infusion combined with accelerated sequential theta burst stimulation in multi-therapy-resistant bipolar depression: A case report
https://www.sciencedirect.com/science/article/abs/pii/S187620182600167X

For ketamine’s urinary problems, a review of the history
From Battlefield Anesthetic to Public-Health Challenge: A Historical Review of Ketamine and Its Genitourinary Sequelae (1960s–Present)
https://www.auajournals.org/doi/abs/10.1097/01.JU.0001191344.82487.eb.17
And for bladder injuries in young people using ketamine, on approaches to treatment
More than a bad trip: a practical approach to emergency and specialist management of ketamine-related bladder injury in children and young people
https://www.sciencedirect.com/science/article/abs/pii/S1751722226000508
And on a multidisciplinary approach to managing ketamine uropathy,
A Multi-Disciplinary Approach to Managing Ketamine Uropathy
https://www.auajournals.org/doi/pdf/10.1097/01.JU.0001191476.64741.7c.28

Kratom

For a kratom extract, a case report of seizures & dangerously fast heart rhythm
Ventricular Tachycardia Following Kratom Ingestion Requiring Extracorporeal Membrane Oxygenation in a Young Woman: Case Report
https://escholarship.org/content/qt9r43b2xz/qt9r43b2xz.pdf

🍃 The Plant & its Products 🍃

In Lithuania, an analysis of hemp for construction, food & cosmetics
Unconventional resources in the context of climate change: opportunities for the development of the hemp market in Lithuania
https://conferences.vilniustech.lt/index.php/ENVIRO/article/view/2278

🌱 Growing 🌱

For medical cannabis, a review of its lifecycle & environmental impact
Recent Advances in Sustainability Assessment of Medicinal Cannabis Cultivation and Production
https://www.mdpi.com/2571-8797/8/3/60

For the continuous cropping of autoflowering hemp, a thesis project on the effects on the plant & its root microbial communities
Effects of Continuous Cropping of Autoflowering Hemp on Rhizosphere Soil
https://cornerstone.lib.mnsu.edu/etds/1601/

On 4 different substrates for cuttings, a comparison of effects on rooting & morphology
Impacts of Commercial and Custom Substrates on Rooting and Morphology of Cannabis sativa ‘Suver Haze’ Stem Cuttings
https://journals.ashs.org/view/journals/horttech/36/3/article-p429.xml

For improving cannabis clone performance, on the benefits of the rhizobacteria (symbiotic root bacteria)
Characterization and application of native Patagonian rhizobacteria to improve clonal performance and growth in Cannabis sativa L
https://assets-eu.researchsquare.com/files/rs-8834956/v1/975e7f58-b5ba-4edf-b55f-83c177a43efb.pdf

For determining cannabis chemotype, a genetic analysis of the B locus & berberine bridge enzyme family on the enzymes for cannabinoid production
The Structure of the Chemotype Determining Locus in Cannabis sativa
https://pmc.ncbi.nlm.nih.gov/articles/PMC13128303/

For the wild cannabis type CSLZ, a genetic analysis of its metabolic differences
Haplotype-Resolved Regulation of Secondary Metabolism in Cannabis
https://watermark02.silverchair.com/uhag159.pdf

In cannabis sex determination, an analysis of 3 genes on the X-chromosome
Three closely linked X‐chromosomal genes potentially control sex determination in Cannabis sativa
https://nph.onlinelibrary.wiley.com/doi/pdf/10.1111/nph.71185

⚙️ Extracting, Analyzing & Formulating ⚙️

For comparing cannabis lab testing, on better ways to capture total yeast & mold counts
Regional (in)Consistency and Comparability of Cannabis Laboratory Testing: A Statistical Exploration of Total Yeast and Mold
https://www.sciencedirect.com/science/article/abs/pii/S0149291826000810

In Brazilian cannabis oils & extracts, on quantifying cannabinoid levels with a high-performance liquid chromatography method coupled with photodiode array detection (HPLC-DAD)
HPLC-DAD Method for Cannabinoid Quantification in Brazilian Cannabis Oils and Extracts
https://assets-eu.researchsquare.com/files/rs-9224291/v1/95bd2949-2d46-46ff-b82f-4641970b2ec8.pdf

🍞 Food & Nutrition 🍞

On hemp seed cake & an analysis of its use as a functional ingredient in baking
Characterization of Hemp Seed Cake and Its Use as a Functional Ingredient for Bakery Application
https://iadns.onlinelibrary.wiley.com/doi/pdf/10.1002/fft2.70280

For livestock feed, on the agronomy of light conditions & harvest times for nutrition value
Nutritive Value and Cannabinoid Potency of Diverse Hemp (Cannabis sativa L.) Varieties Grown under Different Light Conditions and Harvested across Multiple Time Points as a Possible Feed Source for Livestock
https://pubs.acs.org/doi/full/10.1021/acs.jafc.5c16989

On feeding animals hemp (or willow) to lower methane & nitrogen emissions
The potential of willow and hemp bioactive compounds to reduce methane and nitrogen emissions: in vitro and in vivo studies
https://orgprints.org/id/eprint/57624/

🏗️ Industrial Uses & Fiber 🏗️

On creating hemp-derived graphene-like materials (a nanomaterial in high demand these days)
Hemp-Derived Graphene-like Materials: A Renewable Pathway Toward Scalable Conductive Carbon Nanomaterials
https://www.mdpi.com/2075-163X/16/5/475

For sound absorption, on making composites from hemp, flax & denim
Development of Sustainable Lightweight Acoustic Composites from Denim, Flax, and Hemp Fibers
https://acoustics.ippt.gov.pl/index.php/aa/article/view/4349

For hemp as a building material, a review of its potential
Harnessing Hemp: A Comprehensive Review of Its Potential as a Biobased Building Material
https://ascelibrary.org/doi/abs/10.1061/JMCEE7.MTENG-22181

For hemp fiber concrete blocks, an analysis of their greenhouse gas emissions
Greenhouse Gas Emission Assessment of Bottom Ash Block, Hemp and Pineapple Fibers Concrete Blocks
https://ph01.tci-thaijo.org/index.php/JASCI/article/view/263964

For insulation, an analysis of the best ratios of hemp fines (fragments from the hemp seed dehulling process)
Hemp fines as alternative lignocellulosic material for non-woven semi-rigid thermal insulation panels
https://www.sciencedirect.com/science/article/pii/S2589234726000771

For hemp insulation, an analysis of composite materials & their properties
Unlocking the potential of bio-based composites: Durability and sustainability of hemp, flax, and miscanthus with low-carbon binders
https://www.sciencedirect.com/science/article/pii/S259012302601128X

In hemp concrete, modeling of its thermomechanical properties after adding sodium silicate
Thermomechanical characterization and modelling of sodium silicate impregnated hemp concrete
https://www.sciencedirect.com/science/article/abs/pii/S0950061826013425

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

For medical cannabis, a special issue of 38 articles in the American Journal of Preventive Medicine
Cannabis in Transition: Medicalization, Legalization, and Implications for Health
https://www.ajpmonline.org/article/S0749-3797(26)00139-X/abstract

🏥 Public Health & Bioassays 🏥

For people with adverse childhood experiences, there were more likely to experience adverse health effects from the nonmedical use of cannabis or opioids
Adverse Effects of Non-Medical Use of Cannabis or Opioids Associated with Adverse Childhood Experiences
https://www.mdpi.com/1660-4601/23/5/574

For Queer people in Maine, victimization & discrimination were stressors linked to cannabis & alcohol use
Associations of gender minority stress with cannabis and alcohol use in transgender and gender diverse adults in Maine
https://psycnet.apa.org/record/2027-57913-001

In low-income veterans, those with obesity & cannabis use had more poor physical, social & emotional functioning
History of Cannabis Use and Obesity Among U.S. Low-Income Veterans: Associations With Mental Health and Psychosocial Functioning
https://link.springer.com/article/10.1007/s11126-026-10284-5

For detecting cannabinoids in human samples, a review of methods
Extraction and Mass Spectrometry Detection of Cannabinoids in Clinical Samples
https://pubmed.ncbi.nlm.nih.gov/42059241/

For human ingestion of CBD, an analysis of the metabolites found in urine
Cannabidiol metabolites identified by LC-QTOF after controlled dosing
https://www.ovid.com/journals/joat/abstract/10.1093/jat/bkaf098~cannabidiol-metabolites-identified-by-lc-qtof-after

In saliva, on testing for natural & semi-synthetic cannabinoids using bar adsorptive micro extraction
Bar Adsorptive Microextraction for Trace Determination of Natural and Semi-Synthetic Cannabinoids in Saliva
https://www.mdpi.com/2297-8739/13/5/134

For quantifying cannabinoids in roundworms, on validating an ultra-high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS) method
An Accurate Method Based on Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry for the Quantification of Five Cannabinoids in Juvenile and Adult Caenorhabditis elegans
https://pubmed.ncbi.nlm.nih.gov/42024230/

🧒 Adolescents & Young Adults 🧒

On cannabis risk knowledge among young adults, knowledge was highest among Germans & lowest among UK participants, with risk knowledge being lowest among regular cannabis consumers
Through the haze: a multinational cross-sectional comparison of cannabis risk knowledge gaps among young adults
https://link.springer.com/article/10.1186/s42238-026-00439-3

For adolescents in the Turks & Caicos Islands, cannabis use linked to psychological distress, bullying & lower parental involvement
Prevalence and Socio-ecological Correlates of Adolescent Alcohol, Tobacco, and Marijuana Use in the Turks and Caicos Islands
https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2026.1747234/abstract

In young adults, on the effects of the tri-use of alcohol, cannabis & nicotine
Tri-use of alcohol, cannabis, and nicotine in daily life among young adults: A day-level comparison of substance use outcomes to dual-use and alcohol-only use occasions
https://psycnet.apa.org/record/2027-61795-001

🧠 The Brain & Neurological Disorders 🧠

In human brains & a mouse model of Alzheimer’s disease, the levels of CB1 receptors were significantly reduced across a number of brain regions
Reduced CB1 Cannabinoid Receptor Expression in Alzheimer’s Disease and Transgenic Mouse Models
https://onlinelibrary.wiley.com/doi/pdf/10.1002/agm2.70080

In a mouse model of IBS leading to visceral pain & depression in adulthood, environmental enrichment reduced these symptoms via the CB1 receptors in the glutamate (the brain’s most common excitatory neurotransmitter) neurons of the prelimbic cortex & the GABA (the brain’s primary inhibitory neurotransmitter) neurons of the stria terminalis, as well reduced hyperactivity in the paraventricular nucleus
Environmental enrichment reverses ELS-induced visceral pain and depression through a prefrontal-limbic circuit involving CB1Rs
https://www.nature.com/articles/s42003-026-10105-2_reference.pdf

For neuroinflammatory diseases, on incorporating CBD into a glucose nanoparticle for better blood-brain barrier penetration
Non-Invasive Brain Targeted Delivery of Cannabidiol for Alleviating Neuroinflammatory Disease
https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adma.202518697

For neurological diseases, on testing combinations of CBL & CBD with cyclodextrins
Inclusion complexes of cannabinoids with cyclodextrins: Theoretical methods to evaluate and discuss drug repurposing
https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15002545/v1

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

For cannabis & sleep, a survey from the National Sleep Foundation found ~9% of people used cannabis for sleep & 11% were interested
Use and interest in cannabis as a sleep aid: Results from a National Sleep Foundation population survey
https://www.sciencedirect.com/science/article/pii/S2352721826000707

For the effects of different ingestion methods on mental health outcomes, something hidden behind a paywall…
Differentiating Cannabis Use: Associations Between Product Type and Mental Health Outcomes
https://journals.sagepub.com/doi/abs/10.1177/00111287261441245

🦠 The Immune System & Microbial 🦠

For COVID-19, a review on the potential of cannabinoids in combination with the Artemisia genus of plants
A Review of the Investigation of Selected Cannabinoids, Cannabimimetic and Artemisia Combination Treatment Compounds Against COVID-19 and Their Use as Investigational Natural Therapeutic Agents
https://www.preprints.org/frontend/manuscript/2d2b833857af479de5d1b849803b835e/download_pub

For cannabis leaf extracts, a characterization of their compounds as well as their antibiotic & fungicidal effects
Cannabis sativa L. leaf by-products extracts: Chemical composition, antimicrobial and in silico study
https://www.ecoeet.com/Cannabis-sativa-L-leaf-by-products-extracts-Chemical-composition-antimicrobial-and,220997,0,1.html

🦴 Pain, Musculoskeletal, Inflammation & Surgeries 🦴

In a rat model of inflammatory pain, tolerance to the THC-induced decrease in running was more pronounced in males
Repeated Tetrahydrocannabinol Injections Induce Tolerance but Do Not Disrupt Ongoing Behaviour Upon Withdrawal in Male and Female Rats With Inflammatory Pain
https://pmc.ncbi.nlm.nih.gov/articles/PMC13108161/

In skeletal muscle cells, PEA & ibuprofen enhanced levels of the proteins involved in muscle contraction & the extracellular matrix while reducing proteins associated with carbohydrate & lipid metabolism, mostly in the ribosomes (protein processing centers of the cell)
The Effects of Palmitoylethanolamide or Ibuprofen on the Abundance Profile and Synthesis Rate of Proteins in C2C12 Skeletal Myotubes
https://pmc.ncbi.nlm.nih.gov/articles/PMC13104729/

For the painkilling effects of cannabinoids, a modeling study using cheminformatics
QSAR Modeling of Analgesic Cannabinoids via Dual Feature Selection and Support Vector Machines: A Cheminformatics Case Study
https://www.researchgate.net/publication/404812370_QSAR_Modeling_of_Analgesic_Cannabinoids_via_Dual_Feature_Selection_and_Support_Vector_Machines_A_Cheminformatics_Case_StudyQSAR_Modeling_of_Analgesic_Cannabinoids_via_Dual_Feature_Selection_and_Suppor

For chronic pain, on producing co-prodrugs of NSAIDs & PEA
Discovery of novel long-acting co-prodrugs NSAIDs-PEA: Synthesis, nanocrystals preparation, characterizations and antinociceptive effects
https://www.sciencedirect.com/science/article/abs/pii/S1773224726004156

❤️ The Heart & Blood ❤️

For CBD lowering blood pressure, an analysis of the genes & regulatory networks involved
Decoding the antihypertensive mechanism of cannabidiol through integrative bioinformatics and machine learning
https://link.springer.com/article/10.1186/s42238-026-00437-5

In cow blood cells, the terpene beta-caryophyllene modulated their inflammatory responses
Cannabinoid receptor-2 ligand beta-caryophyllene modulates inflammatory responses of bovine peripheral blood mononuclear cells in vitro
https://www.nature.com/articles/s41598-026-49474-3_reference.pdf

💨 The Lungs 💨

In an animal model of lung injury due to blood loss, activating the CB2 receptor decreased inflammatory cytokines, lowered oxidative stress markers, reduced cell death & improved survival rates
CB2 receptor agonist JWH133 attenuates hyperoxia-induced acute lung injury by inhibiting ferroptosis via GPX4 upregulation
https://link.springer.com/article/10.1186/s12931-026-03680-9

🖐️ The Skin & Topicals 🖐️

For facial filling, on using injectable hydrogels with CBD microspheres
Physical and biological synergistic strategies: injectable CNF/CMC hydrogels with cannabidiol@PCL microspheres for durable facial filling
https://www.sciencedirect.com/science/article/abs/pii/S0144861726004935

In cosmetics, on analyzing cannabinoid levels via solid phase extraction with response surface methodology,
Determination of cannabinoids in cosmetics by solid phase extraction with response surface methodology
https://openurl.ebsco.com/EPDB%3Agcd%3A14%3A19141358/detailv2?sid=ebsco%3Aplink%3Acrawler-gcd&id=ebsco%3Agcd%3A192446334&crl=f&jrnl=20972806&link_origin=none

🎗️ Cancer & Chemotherapy 🎗️

For breast & prostate cancer screenings, heavier cannabis use was associated with lower adherence
Association of Cannabis Use With Guideline-Recommended Cancer Screenings: Results From a National Health Behaviors Survey
https://www.ovid.com/jnls/ascojop/abstract/10.1200/op-24-01093~association-of-cannabis-use-with-guideline-recommended

In breast cancer cells, CBD synergized with the treatment olaparib to cause toxicity, cell cycle arrest & DNA damage
Cannabidiol potentiates olaparib-induced cytotoxicity through cell cycle arrest and DNA damage modulation in breast cancer cells
https://link.springer.com/article/10.1007/s11010-026-05550-w

In cervical cancer cells, THC & CBD synergized with cisplatin for diverse anticancer effects
Antiproliferative Effects of Cannabinoids and Cisplatin in Cervical Cancer Cells
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cnr2.70561

For cancer & the enzyme MAGL (which breaks down 2-AG), a review of how it both promotes cancer & exhibits tumor-suppressing characteristics
The dual role of monoacylglycerol lipase (MAGL) in cancer: From oncogenesis to tumor suppression and therapeutic targeting: A review
https://www.sciencedirect.com/science/article/abs/pii/S0141813026022439

For cancer, on targeting the MAGL enzyme
The biological functions of monoacylglycerol lipase (MAGL) in cancer
https://link.springer.com/article/10.1007/s44446-026-00085-z

💊 Synthetic Cannabinoids & Hemp-Derived Cannabinoids 💊

For synthetic cannabinoid use in Brazil, on the demographics of users
Prevalence and correlates of synthetic cannabinoid use in a substance use treatment population: an electronic health record study in Brazil
https://researchonline.gcu.ac.uk/en/publications/prevalence-and-correlates-of-synthetic-cannabinoid-use-in-a-subst/

On the toxicology of the synthetic cannabinoids UR-144, 5F-UR-144 (XLR-11) & XLR-12
Preclinical toxicological profiling of novel psychoactive cyclopropylindole-based synthetic cannabinoids (SCs): UR-144, XLR-11 and XLR-12: molecular aspects and key toxicity endpoints
https://assets-eu.researchsquare.com/files/rs-9197780/v1/f80cbf35-e89d-4a1f-9aaa-5abf30c6a052.pdf

In brain cells, the synthetic cannabinoid 5F-MDMB-PICA caused toxicity, oxidative stress & apoptosis (programmed cellular suicide)
Cytotoxic Effects of the Synthetic Cannabinoid, 5F-MDMB-PICA on Human Glioblastoma U87-MG Cells
https://www.medsci.org/v23p1896.htm

For detecting the synthetic cannabinoid EG-2201, on using a naphthalimide-based probe
Synergistic non-covalent-recognition-enabled highly efficient through-space charge transfer for specific synthetic cannabinoid EG-2201 detection
https://pubs.rsc.org/en/content/articlelanding/2026/ay/d6ay00189k/unauth

🔬 Biochemical Discoveries & Research Tools 🔬

On a cheap synthesis of THC using Suzuki–Miyaura coupling
Versatile Synthesis of Δ9‐Tetrahydrocannabinol and Related Compounds by Protecting‐Group‐Free Suzuki–Miyaura Coupling
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.202600010

For new CB1 drugs, when using AI to analyze their potency
Predicting Affinity and Potency of New Psychoactive Substances at Cannabinoid 1 receptor with Explainable Artificial Intelligence
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1815814/abstract

On incorporating selenium into drugs for the CB1 receptor
Unlocking Selenium Chemical Space via a Programmable Synthesis Platform Bearing Cannabinoid Receptor Recognition Motifs
https://pubs.acs.org/doi/full/10.1021/jacs.5c16359

Thanks.
- lex

PS: For this week’s Delta blues, Arthur “Big Boy” Crudup’s “That’s All Right Mama”. Although he is best known for Elvis covering 3 of his songs, Crudup was an innovator of the blues with a sound all his own (according to Bill Dahl). Born in Mississippi in 1905 to a family of migrant workers, he grew up singing gospel music & later playing local dance halls & cafés. In 1940 at the age of 35, he moved to Chicago to be a musician but was barely making it playing on the streets for change, living in a packing crate underneath an elevated train track. But on the street, the well-known record producer Lester Melrose heard him playing, hired him for a party that night attended by stars like Big Bill Broonzy, Lonnie Johnson & Hudson Whitaker (aka Tampa Red). A hit at the party, Melrose, signed Crudup to RCA’s Bluebird label where he would record ~80 tracks over the next decade.
By the mid-40s, he had a number of songs on the R&B charts including the later Elvis hit “That’s All Right, Mama” (considered by some music historians to be the first rock ‘n’ roll song & leading to Crudup’s sometimes label as the Father of Rock & Roll, a title he accepted was some bemusement). He toured black clubs across the South, sometimes playing with big names like Sonny Boy Williamson II and Elmore James. But by the ‘50s, he stopped recording due to disputes over royalties & low pay. He said, “I realised I was making everybody rich, and here I was poor.” He took to doing farm work & as well as bootlegging, supplying certain establishments with both singing & moonshine. In the late 60s, several people as well as the Songwriters Guild of America were helping him to collect the more than $60k of royalties owed to him but he never collected more than $10k. Crudup said in 1970, “I was born poor, I live poor, and I am going to die poor.” And he did die 4 years later, though his last years saw some success playing the blues & folk festivals for appreciative crowds. Elvis Presley is quoted as saying, “If I had any ambition, it was to be as good as Arthur Crudup.”

This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.
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fibro, pain, pain, hormone alterations, reproductive harms & metabolic helps

Lex Pelger WhiteWhaleCreations — Mon, 11 May 2026 08:46:48 GMT

Cannabinoids & The People,
or; Drugs & Drug Wars

🌟 #ThisWeek 🌟

(#hashtags for jumping to articles by searching for them with your browser)

Cannabinoids for fibromyalgia, neuropathic pain & chronic pain
Vape Week! (hint: increase your THC vape potency by adding CBD)
Hormone levels altered by cannabinoids (#hormones)
Reproductive harms: prenatal cannabis use linked to birth defects, preterm delivery, NICU admission & decreased fertility
Less metabolic diseases in cannabis users (#metabolism)
Preclinical: CBD for menopausal hot flashes + CBD & THC for traumatic brain injuries
War on Drugs: more (abhorrent) boat strikes + analysis of Mexico’s ‘kingpin’ strategy
Psychedelics: Shipibo ayahuasca retreats linked to long-term benefits

[numbers for C&P#186: ~7k words, ~18 minutes reading time, 154 papers]

📌 Editor’s notes 📌:
Female Health:
On LinkedIn, I started a group called ‘Canna-Female Health Club’. I’m going to post everything related to female health or gendered responses to cannabinoids there. Plus, for the strong human studies, I’ll post them publicly on LinkedIn, with everyone tagged, for greater visibility. If anyone wants to join the LinkedIn group chat, just send me a DM on my LinkedIn.

Greetings!
Hello to all the new subscribers. The Substack app appears to be featuring me somewhere, because the flood continues. As always, if anyone needs the data on cannabinoids for any medical conditions, shoot me a message & I’ll send my archives on any of these topics.

Hello everyone,
Welcome to the 186^th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news + the War on Drugs, harm reduction & other psychoactives. Support this work with a paid subscription or by buying me a coffee.

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🎥 Lex’s new work 🎤

@CannabinoidsAndThePeople on YouTube, TikTok & LinkedIn
Canna-edu videos sponsored by the National Cannabis Study (join & get paid $100 to talk about your use of our favorite plant)

Spiritual Smugglers (part 1 of ?)

Canna-science Videos for CV Sciences on YT @CVSciencesInc & on TT @pluscbd
For 30% off their CBD, THC & PEA products, at pluscbdoil.com use the coupon code ‘LEX’

@LexPelgerAndHisBooks on TikTok, YouTube & Instagram:

Pythagoras, Desire & Food (or why I’m glad I never was a foodie)
Russell Hoban’s ‘Soonchild’ & ‘Riddley Walker’ (best kid’s book on shamanism I’ve ever found)

And as always, at the bottom is the album of the week: the Hammond organ of Brother Jack

💖 Ways to support this work 💖

- Venmo: @Lex-Pelger

- PayPal: donate here

📣 A request to spread the word 📣

This newsletter only spreads by word of mouth, so please share to friends & colleagues.

🍃 BEST OF CANNABINOID SCIENCE 🍃

(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)

⚕️ Clinical ⚕️

For fibromyalgia, a meta-analysis of 12 clinical studies found cannabinoids reduced pain intensity & were linked to significant improvements in sleep quality, anxiety, depression & quality of life
Analgesic Effect of Cannabinoids for Fibromyalgia: A Systematic Review and Meta-Analysis
https://pubmed.ncbi.nlm.nih.gov/42013320/

In people with chronic pain, medical cannabis caused a 65% reduction in the use of opioids with an increase in physical functioning scores
Medical Cannabis as an Opiate Alternative: A Prospective Observational Cohort Study
https://assets.cureus.com/uploads/original_article/pdf/432327/20260417-149789-1jln6n.pdf

In 2 people with chronic neuropathic pain, case studies of 1:1 THC:CBD reducing pain intensity, lowering painkilling medications & improving multiple areas of health-related quality of life, especially social functioning & perceived health
Integrating Oral THC:CBD Into Chronic Neuropathic Pain Management in Primary Care: A Two-Patient Observational Case Series
https://digitalcommons.pcom.edu/cgi/viewcontent.cgi

In children with rare epilepsy disorders, CBD improved seizures (sometimes greatly) as well as sleep, behavior & attention
Real-world effectiveness of highly purified cannabidiol in epilepsy associated with 15q11.2-q13.1 duplication and deletion syndromes: A multicenter study
https://pubmed.ncbi.nlm.nih.gov/41992447/
And in children with developmental & epileptic encephalopathies (severe, early-onset brain disorders), CBD isolate reduced seizures & was well-tolerated
Real-world effectiveness and tolerability of highly purified cannabidiol in patients with monogenic developmental and epileptic encephalopathies with highly active epilepsy
https://www.sciencedirect.com/science/article/pii/S1525505026001575

In the hormones of people given high levels of CBD (1500 mg/day for 3.5 days), cortisol & corticosterone levels increased consistently, the precursor steroid 21-OH-progesterone decreased & testosterone levels rose in male subjects (#hormones)
Steroid Hormone Changes After Short-term High-Dose Exposure to Cannabidiol in Healthy Subjects: An Exploratory Study
https://karger.com/mca/article-pdf/doi/10.1159/000552140/4530347/000552140.pdf
And in the steroids of young men, cannabis users had higher levels of testosterone, dihydrotestosterone & androstenedione, suggesting direct effects on the testes or disruption of the hypothalamus-pituitary-gonadal axis
Cannabis consumption is associated with altered steroid metabolism in young men
https://www.nature.com/articles/s43856-026-01469-x

In midlife women with menopause, a survey found that cannabis use was higher in those with mood swings, irritability, anxiety & depression, but also higher odds of cannabis use disorder
Menopause Symptoms and Cannabis Use in a Nationally Representative Sample of Midlife Women
https://www.ovid.com/jnls/greenjournal/abstract/10.1097/aog.0000000000006268.23~menopause-symptoms-and-cannabis-use-in-a-nationally

For metabolic diseases, cannabis use was associated with modestly lower risks of metabolic diseases, hypertension, type 2 diabetes & obesity, especially among people with a lower body-mass index (#metabolism)
Association between Cannabis use and risk of Metabolic disease in UK Biobank
https://www.sciencedirect.com/science/article/abs/pii/S0939475326002243

For US trends of parental cannabis use & cannabis use disorder, 8% of parents living with children use cannabis on most days & 6% met the criteria for cannabis use disorder
Trends in Daily Cannabis Use and Cannabis Use Disorder Among Parents in the U.S., 2012-2024
https://europepmc.org/article/ppr/ppr1151930

Vapes

In a Canadian survey of cannabis vaping, use increased since 2020, especially among youth
Exploring Age and Sex Differences in the Use of Cannabis Vaping Products: Results From the Canadian Cannabis Survey 2020–2023
https://onlinelibrary.wiley.com/doi/pdf/10.1111/dar.70155

When vaping THC, adding CBD increased the THC blood levels
Plasma cannabinoid pharmacokinetics following the inhalation of vaporised cannabis with and without cannabidiol
https://www.sciencedirect.com/science/article/pii/S0376871626001419

In lung cells, cannabis vapor activated the aryl hydrocarbon receptors & altered transcriptional responses related to cancer signaling
Aryl hydrocarbon receptor orchestrates transcriptomic, non-coding and splicing programs that drive human lung epithelial responses to vaporized cannabis in vitro
https://link.springer.com/article/10.1007/s00204-026-04362-7

In young adults, on the effects of their exposures to vaping ads & warnings
Perceptions of Cannabis Vaping Advertising Messages and Warnings Among US Young Adults
https://journals.sagepub.com/doi/abs/10.1177/29767342261429618

📑 Reviews 📑

On CBD, 2 experts on both its potential as a therapeutic agent & its limits, risks & misapplications
Cannabidiol at the crossroads: panacea, placebo, or problem?
https://www.nature.com/articles/s41386-026-02415-0

On the emotional brain, a new book about the cannabinoids’ effects on emotion, memory & motivation
Cannabinoid Modulation of Emotion, Memory, and Motivation
https://link.springer.com/book/10.1007/978-1-4939-2294-9

For the benefits of cannabis on sleep, this review of 20 studies found that it was more effective in people with anxiety or depression
Joint Relations Among Cannabis, Sleep, and Affective Symptomatology: A Scoping Review
https://link.springer.com/article/10.1007/s40429-026-00735-1

For aging, a review on the importance of dosing THC & CBD
Navigating Dose-Effect Complexities and Challenges in Cannabinoid Therapy for Aging-Related Neurobiological Changes
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1794928/abstract

In neurology, a review on the use of CBD
Cannabidiol in Neurology: Current Insights and Translational Perspectives
https://pubmed.ncbi.nlm.nih.gov/41754870/

For central nervous system disorders, a review of cannabinoids with a focus on redox tone, glial state programs, circuit stability & autophagy (cellular recycling) or unfolded protein response signaling
Phytocannabinoids in Central Nervous System Disorders and Frameworks for Cellular Stress Adaptation: A Comprehensive Review
https://link.springer.com/article/10.1186/s44424-026-00052-4

On Alzheimer’s disease (sometimes referred to as type-3 diabetes), a review on the paradox of how the CB1 receptor is essential for normal energy homeostasis but can become a pathological driver & conditions of chronic metabolic access
The Neuro-Metabolic Epidemic and the CB1R Paradox
https://www.sciencedirect.com/science/article/pii/S1471489226000275

On oleoylethanolamide (the endocannabinoid of satiation) for alcohol use disorder, a review of its mechanisms of action
Molecular targets of oleoylethanolamide in the pathogenesis of alcohol use disorder: Mechanisms of central and peripheral action
https://www.sciencedirect.com/science/article/abs/pii/S0741832926001916

For endometriosis, a review of the preclinical evidence found cannabinoids reduced pain via lowering the release of inflammatory mediators, inhibiting signals of the nociceptors (pain receptors), modulation of neuroinflammation & on the lesions themselves, anti-proliferation & apoptosis (programmed cellular suicide)
Insights Into the Role of Cannabinoids in the Management of Endometriosis-Associated Pain
https://www.ovid.com/jnls/greenjournal/abstract/10.1097/aog.0000000000006265.28~insights-into-the-role-of-cannabinoids-in-the-management-of

For wound healing, a review of hydrogels loaded with CBD
Cannabidiol-Loaded Smart Hydrogels for Advanced Wound Healing: Drug Delivery Innovations and Therapeutic Perspectives
https://pubmed.ncbi.nlm.nih.gov/42003194/

In mesenchymal stem cells (multipotent adult stem cells), a review on the benefits of cannabinoids for priming (activating) & differentiation (transformation to a specific cell type)
Phytocannabinoid-induced priming and differentiation of mesenchymal stem cells: Therapeutic potential
https://www.wjgnet.com/1948-0210/full/v18/i4/116829.htm

For schizophrenia, a review of targeting the CB1 receptor
Envisioning Cannabinoid CB1 Receptor Biased Signaling as a Therapeutic Target for Schizophrenia
https://psychiatryonline.org/doi/abs/10.1176/appi.ajp.20250886

For cannabinoids & pain, a review of their effects on the sodium channels
Electrophysiological modulation of pain-related sodium channels by cannabinoids: a systematic review
https://link.springer.com/article/10.1186/s42238-026-00436-6

For the gut-liver axis, a review of the potential benefits of CBD
Cannabidiol as a Modulator of the Gut-Liver Axis: Clinical and Pharmacological Insights into Hepatic and Metabolic Disorder Therapies
https://europepmc.org/article/med/41935387

In cancer & diabetes, a review on the effects of terpenoids
Exploring Terpenoids as Dual-Action Agents in Diabetes and Cancer: A Review of Their Anti-Hyperglycemic, Anti-Glycolytic Actions, and Combination Therapy Potential
https://pubmed.ncbi.nlm.nih.gov/41988874/

⚠️ Harms ⚠️

For atrial septal birth defects, public health data showed higher rates in states with legal cannabis
Space-Time Analysis of Burgeoning US Atrial Septal Defect Rates Driven by Cannabis
https://www.mdpi.com/2039-4713/16/2/68
This is another piece in a birth defects series by Reece & Hulse & here, they suggest “data show that cannabis, including cannabis legalization, is driving the US ASD [atrial septal defect] epidemic”

For pediatric exposure to THC & hemp-derived cannabinoid, the National Poison Data System reported that hemp-derived cannabinoids had a greater association with respiratory depression, low blood pressure & critical care admission
Pediatric Hemp-Derived Cannabinoid and Δ9-THC Exposures: A National Poison Data Study
https://www.sciencedirect.com/science/article/abs/pii/S0022347626001411

In people who used cannabis during pregnancy, they had higher rates of preterm delivery, NICU admission & low birth weight
Cannabis Use During Pregnancy and Effect on Maternal and Fetal Health Outcomes: A Retrospective Chart Review
https://www.ovid.com/jnls/greenjournal/abstract/10.1097/aog.0000000000006268.08~cannabis-use-during-pregnancy-and-effect-on-maternal-and
And in female rats, cannabis prolonged their dioestrous phase (longest phase of cycle where the uterus prepares for a potential pregnancy) & significantly reduced implantation sites, especially with alcohol extracts
Impact of Cannabis sativa on Reproductive Cycling and Fertility Success in Female Albino Rats: A Functional Study
https://hal.science/hal-05596062/

In people with first-episode psychosis, practitioners reported that cannabis users had higher positive symptoms (delusions, hallucinations, disorganized speech & disorganized behavior)
The Impact of Co-occurring Cannabis Use Disorder on Treatment Outcomes in First-Episode Psychosis: A Mixed- Methods Survey of Mental Health Practitioners
https://metroworks.metrostate.edu/cgi/viewcontent.cgi?article=1040&context=student-scholarship

In people with cannabis use disorder, they had higher odds of suicidal ideation
Cannabis Use Disorder and Suicidal Ideation in the United States: Persistent Risk and Stable Trends, 2014–2023
https://www.jsad.com/doi/abs/10.15288/jsad.25-00481

In a young person using CBD for neuropathic pain, a case report of escalating use (400 mg/day) associated with severe mania (irritability, reduced need for sleep, pressured speech, grandiose ideas, heightened activity & aggression)
Mania in a patient using cannabidiol for neuropathic pain
https://journals.lww.com/inpj/fulltext/9900/mania_in_a_patient_using_cannabidiol_for.156.aspx

A case report of a young man with bladder incontinence that resolved after abstinence from his heavy cannabis use
Reversible detrusor acontractility associated with heavy cannabis use: A case report
https://www.sciencedirect.com/science/article/pii/S2214442026001142

For the adolescent use of cannabis, a review found that memory-related impairments were the most consistent findings & that neurocognitive differences detected more in adolescent samples than in young adult samples, with differences between studies in the Americas & Europe
Neuropsychological Effects of Cannabis Use by Continent and Age: A Systematic Review
https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2026.1728743/abstract

🐁 Preclinical 🐁

In chickens exposed to avian infectious bronchitis virus (a coronavirus), CBD suppressed viral replication & markedly alleviated clinical symptoms
Inhibitory effect of cannabidiol on infectious bronchitis virus in chickens in vitro and in vivo
https://link.springer.com/article/10.1007/s00203-026-04886-7

In a rat model of menopause, CBD completely prevented hot flashes but did not alter uterine atrophy
Cannabidiol Prevents Ovariectomy-Induced Thermoregulatory Dysfunction in Rats: A Preclinical Study on Menopausal Vasomotor Symptoms
https://www.mdpi.com/2813-2998/5/2/26

In a rat model of traumatic brain injury, an analysis found both CBD & THC were required for restored learning & memory as well as neuroprotection, with the superior dose ratio being CBD:THC at 300:1 to 10:1
The cannabidiol (CBD): Tetrahydrocanabinol (THC) concentration ratio is critical for neuroprotection and recovery following traumatic brain injury
https://pdf.sciencedirectassets.com/272536/1-s2.0-S0014488626X20039/1-s2.0-S0014488626001196/main.pdf

In a rat model of traumatic brain injury, after one hit, the males had significantly more changes in their endocannabinoid precursors eicosapentaenoic acid & docosapentaenoic acid than females, but females had greater changes after an additional head injury on the following day, suggesting that these endolipids are protective
Sex differences in plasma levels of endocannabinoids and related lipids before and after single and repeated mTBI: an exploratory examination for acute endolipid plasma biomarkers
https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2026.1707732/abstract

In a mouse model of diabetes, hemp seed hull–derived cannabisins A, B & F suppressed sugar spikes after eating
Early-stage antidiabetic potential of hemp seed hull-derived Cannabisins A, B, and F: Integrated computational and experimental evidence for intestinal α-glucosidase inhibition and incretin modulation
https://www.sciencedirect.com/science/article/pii/S075333222600435X

In bacteria resistant to treatment, the combination of silver, CBC & CBG caused antibacterial activity & lowered the formation of biofilms (slimy aggregations that resist treatment)
Broad-spectrum bactericidal synergy of silver-cannabichromene-cannabigerol triple combinations against healthcare-associated pathogens
https://watermark02.silverchair.com/lxag092.pdf

For the forever chemical perfluorooctanoic acid (PFOA), its bone loss effects were linked to reduced levels of the CB1 & CB2 receptor
PFOA effects on osteoblast differentiation: Involvement of oxidative stress and endocannabinoid receptors
https://www.sciencedirect.com/science/article/pii/S0016648026000596

On the prenylated flavonoids of cannabis & their anti-inflammatory effects
Prenylated apigenin derivatives from Cannabis sativa L.: isolation, biosynthesis, and anti-inflammatory properties
https://link.springer.com/article/10.1186/s42238-026-00438-4

🆕 Novel Studies 🆕

(a grab bag section for cool & new stuff)

For the effects of rarely used drugs on predicting arrest, PCP was strongly associated with violent offending but mixed findings for the psychedelics
Substance use predictors of arrest and self-reported criminal behavior in the United States: The role of psychedelics and rarely used drugs
https://journals.sagepub.com/doi/abs/10.1177/02698811261436577

📰 US Headlines & Fav Articles

The new US National Drug Control Strategy report contains concerns about increased youth cannabis use amidst commercialization & link to psychosis & CUD
https://www.marijuanamoment.net/white-house-raises-alarm-about-high-potency-marijuana-and-its-marketing-in-new-national-drug-strategy/
Relatedly, here’s the winners of the ‘Youth THC Prevention Video PSA Contest’
https://www.justthinktwice.gov/media/check-out-winners-youth-thc-prevention-video-psa-contest

The DEA defines HHC as Schedule I
https://www.marijuanamoment.net/dea-clarifies-that-the-synthetic-cannabis-compound-hhc-is-federally-banned-and-doesnt-count-as-legal-hemp/

🌐 International Updates 🌐

An analysis of Europe’s medical cannabis laws & their ambiguities
Prescribed Ambiguity: Medical Cannabis in Europe
https://narkotikapolitisktcenter.se/wp-content/uploads/2026/04/NPC_rapport_mc_ny-1.pdf

In Mauritius, a technical committee formed to examine the various options related to cannabis, ranging from decriminalization to regulated legalization
https://www.cannabiz-africa.com/blog/breakthrough-in-mauritius-as-govt-looks-at-legalization-options-and-calls-for-public-input

A loving history of cannabis in Madagascar
https://stephaniewriter.substack.com/p/the-early-history-of-cannabis-in

A despairing history of the Canadian cannabis industry
https://wtfcanada.substack.com/p/the-canadian-cannabis-industry-is

⚖️ Business, Laws & Education ⚖️

In an analysis of mental health & labor markets, adult-use cannabis laws were linked to young adults reporting more poor mental health days, less exercise & more long-term unemployment while adults over 50 report less joint pain, more exercise & more income gains
Asymmetric Effects of Recreational Marijuana Laws on Mental Health and Labor Markets
https://jonathan-norris.github.io/files/rml_paper_draft.pdf

On Nabis, a California success story in the business of cannabis fulfillment
https://www.sfgate.com/cannabis/article/nabis-california-cannabis-distributor-22192035.php

In US public health data, medical cannabis laws were associated with a 2% greater rate of cannabis use & a small increased rate of cannabis use disorder (0.3%) & driving under the influence of cannabis (0.4%)
Medical Cannabis Legalization and its Association with Cannabis use, Cannabis use Disorder, and Intoxicated Driving: Findings from the National Survey on Drug use and Health, 2016-2019
https://link.springer.com/article/10.1007/s10597-026-01626-5

As states legalize, on how consumers transition between illicit & legal cannabis
How Consumers Transition Between Illicit and Legal Cannabis Markets in Early Legalization Periods? Evidence from a National Panel with a Recent Policy Shock
https://assets-eu.researchsquare.com/files/rs-9381647/v1_covered_40c96d7d-ad38-48cb-8a8d-f6c3160de9bf.pdf

🚓 The War on Drugs 🚓

On May 4, another US strike in the Caribbean on a suspected drug vessel killed 2 people
https://www.foxnews.com/world/us-kills-2-suspected-drug-traffickers-boat-strike
And another one in the eastern Pacific killed 3 people
https://www.foxnews.com/world/three-suspected-narco-terrorists-killed-us-military-strike-drug-trafficking-vessel-eastern-pacific
And on how Trump’s boat strikes aren’t actually stopping the flow of drugs & the human rights horror show of murdering low-level laborers in the drug trade
https://theintercept.com/2026/05/04/trump-boat-strikes-fentanyl-cocaine-drug-supply/
““These are extrajudicial executions, or even just murders — something similar to a cop shooting a fleeing suspect in the back when there is no self-defense justification,” said Adam Isacson, the director for defense oversight at Washington Office on Latin America, a human rights group. He called the growing death toll “a gross human rights violation.””

And here’s a timeline & map of the strikes by Insight Crime
https://insightcrime.org/news/timeline-us-strikes-against-alleged-drug-boats/

The Secretary of State announced visa bans on 75 family members & associates tied to the Sinaloa cartel
https://www.aol.com/narco-terrorist-family-members-targeted-174726376.html

On the global failures of drug prohibition, a new book with human rights-centered alternatives
Criminal Drug Policy: From Prohibition to Regulation
https://link.springer.com/book/10.1007/978-3-032-14702-8

In Mexico, on a history of how the “kingpin strategy has created leadership vacuums, generating the atomization of Mexico’s criminal landscape and more than 100 horizontally integrated networks that operate in nearly every corner of the country”
https://insightcrime.org/news/is-mexico-running-out-of-kingpins/

On the US War on Drugs, an Algerian study concluded that enforcement produced only short-term reductions in drug use, while prevention, treatment & harm reduction measures were more cost-effective
An Anatomy of a Successful Strategy for Objective Fulfillment: The Case of the U.S. War on Drugs
https://asjp.cerist.dz/en/article/290564

For Vietnam & China, an analysis of their cross-border drug trafficking
Cross-border drug trafficking between Vietnam and China: asymmetries, opportunities, and regulatory responses
https://link.springer.com/article/10.1007/s43545-026-01445-1

‘Just How Many Kilos of Contraband Cannabis can a [Toyota] Quantum Carry?’
https://www.cannabiz-africa.com/blog/just-how-many-kilos-of-contraband-cannabis-can-a-quantum-carry
Apparently, an impressive 1,025 kg.

🛡️ Harm Reduction News 🛡️

In Vancouver, the mayor is pushing an “urgent” motion to block an overdose prevention site
https://vancouver.citynews.ca/2026/05/05/vancouver-proposed-overdose-prevention-site-mayor-motion/

In Winnipeg, a moving account of the drug overdose crisis & the importance of harm reduction
https://www.winnipegfreepress.com/breakingnews/2026/05/07/the-thousand-yard-stares-of-winnipegs-drug-crisis

Harm Reduction Research

In Indigenous communities, a review of their harm reduction approaches
Harm reduction approaches within Indigenous communities across Turtle Island: A scoping review of peer-reviewed and grey literature
https://link.springer.com/article/10.1186/s12954-026-01434-w

For syringe services programs, on how legal restrictions like local authorization & a “one for one” exchange model impair public health
Syringe Services Program Legal Restrictions Are Counter to Public Health and the Experience of People Who Use Drugs
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/43E3C1F44176A5F302F5029C77AAE9EA/S1073110526102332a.pdf/syringe_services_program_legal_restrictions_are_counter_to_public_health_and_the_experience_of_people_who_use_drugs.pdf

For syringe service programs in the US, a map found limited availability, especially for walking & in rural areas
A geospatial analysis of access to syringe services programs in the United States, 2023
https://www.sciencedirect.com/science/article/pii/S0376871626001493

In providing medication for opioid use disorder in jails, on the barriers & facilitators to implementation
Medication for Opioid Use Disorder in Jail Settings: Barriers and Facilitators to Implementation
https://journals.sagepub.com/doi/abs/10.1177/26320770261441800

Lessons on installing naloxone vending machines in rural communities
Distributing intranasal naloxone in rural communities: Implementation of a novel approach
https://journals.sagepub.com/doi/full/10.1177/26320770261434033

For harm reduction vending machines, an analysis of social media discussions on them
Harm reduction vending machines in the digital sphere: Social media discourse, misinformation, and health promotion implications
https://www.tandfonline.com/doi/full/10.1080/10550887.2026.2658657

🍄 Psychoactives, Psychedelics & Plant Medicines 🍄

Gabon declared iboga & ibogaine to be part of the country’s national strategic heritage & created a sovereign fund to developing it
https://www.ecofinagency.com/news-finances/0505-55250-gabon-creates-sovereign-fund-to-control-and-develop-iboga-industry

On the birth of psychedelic harm reduction & the Haight Ashbury Free Medical Clinic
https://www.ecstaticintegration.org/p/david-e-smith-on-the-haight-free

Psychedelics & MDMA

For Shipibo-led ayahuasca retreats at the Temple of the Way of Light in the Peruvian Amazon, follow-up studies found quality of life improvements across all measured domains, primarily in spiritual well-being, mental health & personal growth
Symmetrical Global Mental Health (Sym-GMH): Ayahuasca and shipibo traditional medicine for lasting changes in personality and quality of life
https://www.sciencedirect.com/science/article/pii/S2950484826000111

For Oregon’s psilocybin services, an analysis of licensing, manufacturing rules, labeling guidelines & pricing information
Oregon’s Psilocybin Services: A Summary and Public Health Commentary
https://newprairiepress.org/cgi/viewcontent.cgi?article=1377&context=hbr

On psilocybin for depression, a meta-analysis of 13 clinical trials found no statistically significant overall antidepressant effect
The efficacy and safety of psilocybin-assisted therapy for major depressive disorder: a meta-analytic review of clinical outcomes
https://www.mental-wellness-journal.net/mw/article/view/40

In older adults, a review on psilocybin for mental health & neurodegenerative disorders
Psilocybin in Older Adults: Therapeutic Opportunities in Inflammation-Driven Disorders of Aging—From Depression to Neurodegeneration
https://www.preprints.org/frontend/manuscript/4eacc0678ac8fe46d3aeecb9393ece49/download_pub

On psychedelics for autism, a review of the studies
Psychedelics and Autism Therapy: A Review of Current Research and Future Directions
https://www.mdpi.com/1467-3045/48/4/417

For female rats in estrus, psilocybin increased anxiety-like behavior in any stage of their cycle, but for those in estrus, both psilocybin & norbaeocystin (a psilocybin analog aka 4-phosphoryloxytryptamine (4-PO-T)) lessened their startle response to a stimulus more quickly, suggesting norbaeocystin for reducing symptoms of hyperarousal
Role of estrus in the acute anxiogenic effects of psilocybin and the related tryptamine, norbaeocystin
https://digitalcommons.onu.edu/student_research_colloquium/2026/Posters/4/

Ketamine

For youth using ketamine, interviews on the life transitions & accessibility that shape their use
Understanding ketamine use in Blackpool: A qualitative study of life transitions and social contexts
https://openjournals.ljmu.ac.uk/PHIJ/article/view/3561

In people with bipolar disorder, intravenous ketamine produced significant & sustained antidepressant effects
Faster and greater antidepressant response to intravenous ketamine in bipolar compared with unipolar treatment-resistant depression: Diagnostic and sex-related findings from a naturalistic study
https://www.sciencedirect.com/science/article/abs/pii/S0165178126002453

In children with psychiatric conditions, a review on the use of ketamine
Use of Ketamine and Esketamine in the Pediatric Population: Current Evidence and Clinical Applications
https://psychiatryonline.org/doi/abs/10.1176/appi.focus.20250040

When using ketamine for mood & anxiety disorders, a review of the potential liver toxicity
Evaluating the potential risk of ketamine-induced hepatotoxicity in the treatment of mood and anxiety disorders: A systematic review
https://www.sciencedirect.com/science/article/pii/S0163834326000769

For obsessive-compulsive disorder, a review of 21 studies on ketamine & esketamine
Ketamine and Esketamine in Obsessive–Compulsive Disorder: A Scoping Review of Clinical and Mechanistic Evidence
https://www.mdpi.com/1424-8247/19/4/628

In people with treatment-resistant depression, a review of ketamine
Ketamine or Esketamine in Special Populations of Patients With Treatment-Resistant Depression
https://europepmc.org/article/pmc/pmc13064306

For ketamine versus electroconvulsive therapy (ECT) for depression, a review on time to relapse found ECT potentially causing longer remission
Comparison of average time-to-relapse following ECT versus ketamine – A systematic review
https://journals.sagepub.com/doi/abs/10.1177/02698811261430502

Kratom

In people with opioid use disorder & kratom use, their rates of serious mental illness more than doubled over a three-year period
Co-occurring substance use disorders and the compounding effect of kratom on serious mental illness, US, 2021–2023
https://www.tandfonline.com/doi/abs/10.1080/00952990.2026.2646242

For people who use drugs in Malaysia, on how they view kratom as a harm reduction tool
The perceive utility of kratom (Mitragyna speciosa) as a harm reduction agent among people who use drugs (PWUDs) in Malaysia
https://www.tandfonline.com/doi/full/10.1080/14659891.2026.2658809

In states that had bans on kratom, they had slower increases to their kratom reports to poison centers
Association between state-level kratom regulations and poison center-reported severe medical outcomes and healthcare use: A United States national analysis
https://pubmed.ncbi.nlm.nih.gov/42015466/

For analyzing the interstate commerce of kratom brands, these researchers called 600+ stores
Kratom Brands in Vape Shops Across the US
https://newprairiepress.org/cgi/viewcontent.cgi?article=1350&context=hbr

On the molecular & epigenetic effects of kratom, a review of 20 studies
Decoding kratom: molecular mechanisms and epigenetic factors in use and dependence
https://www.nature.com/articles/s41398-026-04022-5_reference.pdf

Cathinones

A fatal case report of metaphedrone (3-MMC)
Toxicological and forensic aspects of a fatal 3-methylmethcathinone intoxication: A case report
https://www.sciencedirect.com/science/article/pii/S1752928X26000831

🍃 The Plant & its Products 🍃

🌱 Growing 🌱

For hemp under drought conditions, on optimizing fertilization for yield
Optimizing hemp (Cannabis sativa L.) physiology and cannabidiol content through integrated chemical and bio-nitrogen fertilization under drought
https://www.tandfonline.com/doi/pdf/10.1080/03650340.2026.2657117

For micropropagation, development of a novel medium for improved explant performance
Biotecnologie e Genomica Funzionale per il Miglioramento Genetico di Cannabis sativa L.: dai Sistemi In vitro alla Mutagenesi per la Validazione Funzionale dei Geni
https://tesidottorato.depositolegale.it/handle/20.500.14242/364448

In cannabis infected with hop latent viroid, it was more susceptible to infection by Fusarium & powdery mildew
Hop latent viroid-infected cannabis (Cannabis sativa L.) plants show enhanced susceptibility to Fusarium root and stem rot and powdery mildew infection
https://www.tandfonline.com/doi/pdf/10.1080/07060661.2026.2649769

On the effects of cannabis extracts on parasitic nematodes & cannabinoid & terpene profiles
Cannabis flower crude extracts as belowground infochemicals shaping the chemotactic responses of parasitic nematodes
https://www.nature.com/articles/s41598-026-49877-2_reference.pdf

For 2 drug-type cannabis chemotypes, a transcriptional analysis
Transcriptome assemblies for two drug‐type cannabis chemotypes by long‐read RNA sequencing
https://acsess.onlinelibrary.wiley.com/doi/pdf/10.1002/tpg2.70240

For synthesis of THCV, a computational mapping of the involved metabolic networks
THCV Biosynthesis Pathway Identification: Computational Validation of Novel Candidate Genes
https://www.researchgate.net/publication/403809172_THCV_Biosynthesis_Pathway_Identification_Computational_Validation_of_Novel_Candidate_Genes

For the flowering of cannabis, a thesis project genetically analyzing the traits in different environments
Genetic analysis of Cannabis flowering traits in differential environments
https://scholar.sun.ac.za/server/api/core/bitstreams/86bd6a18-b25f-492f-a31d-1d6c618676b1/content

In hemp’s BES1 transcription factor family, a genetic analysis of its regulation of the alkali stress response
Genome-wide identification and functional dissection of the BES1 family reveals key regulators of alkali stress response in hemp
https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2026.1819515/full

Upon infection by the fungus Sclerotinia sclerotiorum, on the genetic & cellular response of cannabis
Dual RNA sequencing reveals the transcriptomic and cellular response of Cannabis sativa to infection by the fungal pathogen Sclerotinia sclerotiorum
https://www.nature.com/articles/s41598-026-47998-2_reference.pdf

For the fungal pathogen Golovinomyces ambrosiae, a genetic analysis
Hybrid genome assembly of the cannabis powdery mildew agent Golovinomyces ambrosiae uncovers important resources for deciphering virulence factors
https://www.researchsquare.com/article/rs-9162455/v1

⚙️ Extracting, Analyzing & Formulating ⚙️

For measuring cannabinoid levels, on the challenges of cannabis-based products
Analytical challenges in cannabinoid quantification of cannabis based products
https://www.um.edu.mt/library/oar/handle/123456789/145539

On quantifying THC & CBD using dielectric barrier discharge ionization
Direct Chromatography-Free Quantification of THC and CBD in Cannabis by CID and EI-Like Fragmentation Enabled by Dielectric Barrier Discharge Ionization
https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15002048/v1

In face cream, on quantifying CBC levels with ultrahigh-performance liquid chromatography ultraviolet detection
Quantification of Cannabichromene In Hemp-Infused Face Cream Using Ultrahigh-Performance Liquid Chromatography With Ultraviolet Detection
https://www.researchgate.net/publication/393985640_Quantification_of_Cannabichromene_In_Hemp-Infused_Face_Cream_Using_Ultrahigh-Performance_Liquid_Chromatography_With_Ultraviolet_Detection

🍞 Food & Nutrition 🍞

In online sentiment about cannabis-infused foods in the Netherlands, text mining found predominantly positive sentiment, but concerns on dosage, first-time experiences & panic responses
Going to space with transformers: a RoBERTa- and BERTopic-powered exploration of sentiment and themes in cannabis-infused food and beverage discourse in the Netherlands
https://www.tandfonline.com/doi/abs/10.1080/10548408.2026.2639330

On improving prebiotic functionality with a conjugate of hemp protein & chito-oligosaccharides
Hemp protein functional properties, amino acid profile, and growth promotion of Lactiplantibacillus plantarum via ultrasound-induced Maillard reaction with Chito-oligosaccharides
https://www.sciencedirect.com/science/article/abs/pii/S0308814626014573

For ruminant feed, hemp hulls caused cannabinoids to be detected in animal by-products, suggesting the need for a withdrawal feeding period
Evaluation of hemp hulls and screenings as alternative feed ingredients for ruminants
https://cdnsciencepub.com/doi/abs/10.1139/cjas-2025-0117

🏗️ Industrial Uses & Fiber 🏗️

On burning sewage sludge with oak bark & hemp hurd for enhanced biochar properties
Co-pyrolysis of municipal sewage sludge with oak bark and hemp hurd to tailor biochar stability, carbon sequestration and heavy metal immobilization
https://www.sciencedirect.com/science/article/abs/pii/S0956053X2600190X

On the potential of using hemp degumming waste liquid as a source of carbon for bacterial cellulose fermentation
From Hemp Degumming Waste Liquid to a Functional Carbon Source: Bacterial Cellulose Composites with Sustained Release
https://www.tandfonline.com/doi/abs/10.1080/00222348.2026.2656191

For a protein emulsion gel, on combining resveratrol with soybean protein isolate & hemp protein isolate
Structural properties, rheological characteristics, and drug delivery efficiency of resveratrol-loaded soybean protein isolate and hemp protein isolate emulsion gels: Synergistic effects of carboxymethyl cellulose incorporation and ultrasound treatment
https://www.sciencedirect.com/science/article/pii/S2590157526003986

For storing pork, on a hemp seed protein-based film
Hemp Seed Protein-Based Emulsion Films Containing Propolis Flavonoids: Enhanced Physicochemical Properties and Preservation of Chilled Pork
https://www.mdpi.com/2079-6412/16/4/489

For biodegradable packaging film, on combining polyvinyl alcohol with microcrystalline cellulose from hemp waste
Hydrophobic Polyvinyl Alcohol and Microcrystalline Cellulose From Hemp Waste Composite Films by Using Alkyl Ketene Dimer Wax for Packaging Applications
https://4spepublications.onlinelibrary.wiley.com/doi/abs/10.1002/pen.70535

On creating microfibrillated cellulose from hemp hurds for packaging materials
Carboxymethyl and dialdehyde microfibrillated cellulose from hemp hurds: Role of fibrillation energy in chemical reactivity and functional properties
https://www.sciencedirect.com/science/article/pii/S2352940726001526

In foams, testing their stability with hemp proteins & hemp protein-pectin complexes
Correlating surface rheology with bulk rheology in foams stabilized by hemp proteins and hemp protein-pectin complexes
https://www.sciencedirect.com/science/article/pii/S0021979726007411

For the deformation of a hemp biopolymer, on creating a micromechanical model for testing
A Compact Micromechanical Model for the Elastic-Viscoplastic Deformability of PLA-Hemp Biocomposites
https://www.scientific.net/SSP.390.197.pdf

For analyzing the water absorption properties of building materials, a test for concrete & hemp concrete
Development of an inverse method for identifying the hygric properties of hysteretic building materials: Application on cellular concrete and hemp-concrete
https://www.sciencedirect.com/science/article/pii/S2352710226009228

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

For CBD, an Iranian review of its targets & therapeutic effects
Cannabidiol: Pharmaceutical formulations and biomedical applications
https://ijbms.mums.ac.ir/article_27439_10f104cb197570bd7b4127799188c374.pdf

🏥 Public Health & Bioassays 🏥

For cannabis use among BIPOC women during COVID, they had lower rates of using cannabis to manage chronic health conditions
Cannabis Use and Mental Health Coping Behavior among Black, Indigenous, and People of Color Women during the COVID-19 Pandemic: Results from the COVID-19 Cannabis Health Study
https://link.springer.com/article/10.1007/s40615-026-02937-9
And on the Queer use of cannabis during COVID
Exploring How Cannabis Use Featured in the Mental Health Experiences and Daily Lives of Queer, Non-Binary, and Trans Youth in the Early Phases of the COVID-19 Pandemic: A Mixed-Methods Study in Canada
https://www.tandfonline.com/doi/abs/10.1080/00918369.2026.2654058

For people detecting cannabis intoxication, they found it much more difficult than detecting alcohol intoxication
What Cues Do Laypeople Use to Detect Alcohol and Cannabis Intoxication?
https://pmc.ncbi.nlm.nih.gov/articles/PMC13096672/

On cannabis consumption & the fading affect bias (the faster fading of unpleasant than pleasant affect)
Marijuana Consumption and Reactivity Are Positively Associated with the Fading Affect Bias for Marijuana Events in Person and Online
https://www.researchgate.net/publication/403996843_Marijuana_Consumption_and_Reactivity_Are_Positively_Associated_with_the_Fading_Affect_Bias_for_Marijuana_Events_in_Person_and_Online

For tobacco & cannabis use, on the interactions of smoking versus vaping each substance
A cross-sectional analysis of Behavioral Risk Factor Surveillance System (BRFSS) data to determine if tobacco and cannabis methods of administration are likely to be consistent across products
https://link.springer.com/article/10.1186/s12931-026-03638-x

During storage of plasma samples in gel separation tubes, on how the cannabinoids get absorbed by the tubes
Adsorption of Tetrahydrocannabinol, Metabolites, and Related Compounds During Storage of Plasma Samples in Gel Separation Tubes
https://www.ovid.com/journals/joat/abstract/10.1093/jat/bkag001~adsorption-of-tetrahydrocannabinol-metabolites-and-related
“Over a three-month period, concentrations in PSTs [plasma separation tubes] decreased for THC by 83% and 81%, THC-OH by 66% and 63%, CBD by 69% and 62%, and CBN by 75% and 70% in LP [low concentration] and HP [high concentration] samples, respectively.”

For hair analysis of cannabinoid metabolites, on the effects of different washing protocols
Influence of Different Washing Hair Procedures in the Quantitative Determination of THC and THCCOOH
https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdf/10.1002/dta.70073
And for hair analysis of the cannabinoid metabolite THC-COOH, on the challenges of interpretation
Challenges in the Interpretation of Isolated THC‐COOH Detection in Hair: Forensic and Clinical Implications
https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/dta.70072

🧒 Adolescents & Young Adults 🧒

For California adolescent cannabis use, it increased following legalization & decreased following COVID
Adolescent Cannabis Use After Cannabis Legalization and the COVID-19 Pandemic
https://pubmed.ncbi.nlm.nih.gov/41996112/

For social media influencers’ effects on youth cigar & cannabis use, cigar marketing was associated with increased cannabis use
The role of social media influencer promotion in initiation and use of cigar, little cigar, cigarillo, and cannabis products among US youth and young adults: Using exogenous marketing exposure measures
https://www.sciencedirect.com/science/article/abs/pii/S0277953626003928

In Lebanon youth, on the factors associated with their opposition or support for cannabis legalization
Factors associated with youth opposition or support for cannabis legalization in Lebanon
https://link.springer.com/article/10.1186/s42238-026-00426-8

In young adults co-using alcohol & cannabis, their expectancies of stimulant effects or relaxing effects were moderately associated with their subjective responses
Real-time discrepancies between simultaneous alcohol and cannabis expectancies and subjective responses
https://www.sciencedirect.com/science/article/abs/pii/S0376871626001444

For adolescents co-using nicotine & cannabis, a survey on their range of co-use behaviors
Patterns in methods, timing, and sequence of nicotine and cannabis co-use among adolescents
https://www.sciencedirect.com/science/article/pii/S0376871626001432

🧠 The Brain & Neurological Disorders 🧠

In epilepsy, an industry review on the interactions of cannabinoids & terpenes
Modulating Neural Excitability in Epilepsy: A Systems-Level Perspective on Cannabinoid–Terpene Signaling
https://www.preprints.org/frontend/manuscript/6334546e8973ab11bc56b239f999c429/download_pub

For a mouse model of the behavior of dopamine-based active avoidance, retrograde release of the endocannabinoid 2-AG from the ventral tegmental area dopamine neurons worked via the CB1 receptors
Midbrain endocannabinoids actuate dopamine-based action selection
https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00376-1

For anxiety drugs, on how a receptor for GABA (the brain’s most common inhibitory neurotransmitter) is modulated by the endocannabinoid 2-AG
Direct Modulation of Human GABA-A α1β2γ2 Receptors by the Endocannabinoid 2-Arachidonoylglycerol: Implications for Cannabinoid-Related Ligands and Limitations for Anxiolytic Drug Development
https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1813618/abstract

In brain slices of the hippocampus (a memory center of the brain), cannabinoids did not cause strong changes to sharp wave-ripples (network events essential for information processing)
Robust Intrinsic Dorsoventral Organization of Hippocampal Sharp Wave–Ripples Persists During Cannabinoid Modulation
https://www.preprints.org/frontend/manuscript/8d6c19382cdb9f13d7a91915090e200d/download_pub

In rat brain tissue, blocking the CB1 receptor disrupted key epigenetic regulatory mechanisms
Therapeutically relevant rimonabant exposure drives epigenetic remodeling in neuronal cells and rat brain tissue
https://link.springer.com/article/10.1007/s00204-026-04369-0

In the microglia (guardian immune cells of the brain), the endocannabinoid transporter ABHD12 acts as an opposing enzyme to DAGLβ (which synthesizes the endocannabinoid 2-AG) to modulate microglial immune function
Stimulus-Driven Remodeling of Microglial Endocannabinoid Metabolism Illuminates ABHD12 Function in Immunity
https://pubs.acs.org/doi/abs/10.1021/acschemneuro.5c00985

In a rat model of Parkinson’s disease, on determining brain levels of anandamide & 2-AG via solid-phase microextraction
In Vivo Negligible Depletion SPME for the Determination of Free and Total Concentrations of Anandamide and 2-Arachidonoylglycerol in the Brain of a Parkinson’s Disease Rat Model
https://pubs.acs.org/doi/abs/10.1021/acs.analchem.5c07902

For brain delivery, on optimizing CBD lipid nanocapsules
Improved drug delivery across the blood-brain barrier through post-insertion functionalization of lipid nanocapsules with cannabidiol using click chemistry
https://www.sciencedirect.com/science/article/pii/S0927776526003243

For neuroprotection against stroke, nanoparticles with CBD, apigenin & polysaccharides
Multifunctional Cannabidiol-Loaded Nanoparticles Based on Herbal-Derived Bioactive Materials Provide Enhanced Neuroprotection against Ischemic Stroke
https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.6c00054

For Dravet syndrome, nanostructured lipid carriers with CBD & stiripentol (an antiseizure medication)
Lipid Nanoparticles with Stiripentol and Cannabidiol Oil: From Rational Optimization to Preclinical Characterization
https://www.mdpi.com/1999-4923/18/4/503

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

For emotional disorders, cannabis use was associated with an increased risk that was stronger in females
Positive emotional dysregulation as a mediator between cannabis use and emotional disorder risk: Sex-specific pathways
https://www.sciencedirect.com/science/article/pii/S0165178126002416

For reducing the use of cannabis and/or tobacco, a review of 32 studies on interventions found the best evidence for motivational interventions
Health education interventions to reduce cannabis and tobacco smoking-related harms among people who use cannabis: a systematic review
https://kclpure.kcl.ac.uk/portal/en/publications/health-education-interventions-to-reduce-cannabis-and-tobacco-smo/

On the challenges of recruiting people with heavy cannabis use into online interventions
Lessons learned: challenges in recruiting and engaging people with heavy cannabis use for online interventions in Canada
https://link.springer.com/article/10.1186/s42238-026-00425-9

In an adult test of memories of stress, THC did not dampen most of the subjective or physiological responses to images eliciting stressful memories
Acute and delayed effects of THC on memories of stress in healthy adults
https://link.springer.com/article/10.1007/s00213-026-07064-1

In people at high risk for psychosis, the co-use of cannabis & tobacco was associated with lower neurocognitive performance
Cannabis and Tobacco Co-Use is Associated with Impaired Neurocognitive Performance in Individuals at Clinical High Risk for Psychosis
https://www.sciencedirect.com/science/article/pii/S2451902226001199

🦠 The Immune System & Microbial 🦠

On the antibiotic effects of a structural polymer loaded with phytocannabinoids & hemp fiber
Chemical characterization and in vitro antimicrobial evaluation of phytocannabinoid-loaded polymethyl methacrylate (PMMA) reinforced with natural fibers
https://www.sciencedirect.com/science/article/pii/S2352492826005945

🧬 Reproduction & Hormones 🧬

In women who had their first baby, cannabis exposure 2-7 years after pregnancy was not associated with hypertension
Cannabis Exposure After Pregnancy and Development of Hypertension in the nuMoM2b Heart Health Study
https://journals.lww.com/ogopen/fulltext/2026/04000/cannabis_exposure_after_pregnancy_and_development.13.aspx

🦴 Pain, Musculoskeletal, Inflammation & Surgeries 🦴

After a spinal surgery, those with cannabis use disorder had higher rates of mental health service engagement but lower rates of opioid use, with no differences at the 1 or 2-year follow-up
Impact of cannabis use disorder on risk of surgical complications following anterior cervical discectomy and fusion
https://link.springer.com/article/10.1007/s00586-026-09949-3

In people using cannabis for chronic pain, interviews using a biopsychosocial model
The greater the pleiotropic effects, the greater the benefits - cannabis as a “biopsychosocial” drug: a mixed-methods study on chronic non-cancer pain
https://link.springer.com/article/10.1186/s42238-026-00440-w

In people with pain, abstinence from cannabis was not related to their acute pain perception, though females showed overall higher levels of anandamide, PEA & oleoylethanolamide (the endocannabinoid of satiation)
Cannabis use patterns and perception of acute pain during brief abstinence: sex-dependent associations with circulating cannabinoid levels
https://link.springer.com/article/10.1007/s00213-026-07063-2

For pain management, a review article of targeting the endocannabinoid transporter FABP5
Evaluating FABP5 as a Therapeutic Target for Pain Management
https://onlinelibrary.wiley.com/doi/pdf/10.1002/ejp.70267

In a rat model of neuropathic pain, this thesis project found that environmental enrichment raised endocannabinoid levels for pain control
Investigation of the effects of environmental enrichment in a rat model of neuropathic pain and related comorbidities: role of the endocannabinoid system
https://researchrepository.universityofgalway.ie/entities/publication/107faaa0-f88f-4971-b089-0ed2aa67697c

On synapses with nociceptors (pain-detecting receptors), this thesis project found anandamide depressed synapses with nociceptors but potentiated synapses that detected pressure
Role of Concentration in Opposing Effects of Anandamide on Nociceptive Synapses versus Non-Nociceptive Synapses
https://www.eneuro.org/content/eneuro/early/2026/04/20/ENEURO.0480-25.2026.full.pdf

For osteoarthritis, screening new drugs for activating the CB2 receptor
Virtual Screening and Molecular Dynamics Simulations of Cannabinoid Receptor 2 Agonists as Drug Candidates for Osteoarthritis Therapy
https://www.frontiersin.org/journals/drug-discovery/articles/10.3389/fddsv.2026.1809420/abstract

🍽️ The Guts, Nutrition & the Microbiome 🍽️

In dogs, CBD caused a downregulation of apolipoproteins (APOA4, APOC3, APOC1 & APOH) & upregulation of hemoglobin subunits (HBA and HBB), while high doses upregulated proteins involved in vascular integrity & tissue scaffolding (e.g., TGFB1, PDGFRB & VWF)
Formulation-Specific Dose-Response in the Serum Proteome of Healthy Dogs Following Cannabidiol Administration
https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1803263/abstract

💨 The Lungs 💨

In a mouse model of airway hyperresponsiveness & allergic asthma, activating the CB2 receptor suppressed airway hyperresponsiveness & inflammation via the CB2 & TRPV1 receptors
Targeting Cannabinoid CB2 Receptors to Attenuate Airway Inflammation and Hyperresponsiveness in Allergic Asthma: Does the TRPV1 Receptor Play a Role?
https://europepmc.org/article/med/41968554

For asthma & lung diseases, on optimizing CBD microparticles
Sodium Stearate-Assisted Optimization of a Cannabidiol Dry Powder Inhaler for Enhanced Dissolution and Aerosol Performance
https://www.mdpi.com/1999-4923/18/4/512

💧 The Genitourinary System 💧

In people with a kidney injury, drainage led to increased levels of anandamide, N-palmitoylethanolamine & N-oleoylethanolamine
Endocannabinoid responses to relief of obstruction in acute injured kidney: a prospective observational study
https://journals.sagepub.com/doi/full/10.1177/17562872261442624

🎗️ Cancer & Chemotherapy 🎗️

In breast cancer cells, CBD decreased colony formation, inhibited cell invasion & induced apoptosis (programmed cellular suicide)
The Effect of Cannabidiol on Cancer-Pathway Genes in Doxorubicin-Sensitive and Resistant Breast Cancer Cells
https://www.mdpi.com/1424-8247/19/4/615

In lung cancer cells, inhibiting the FAAH enzyme (which breaks down anandamide) boosted the drug cisplatin’s anti-tumor efficacy
FAAH initiates a positive feedback loop to promote lung adenocarcinoma progression through inhibition of ferroptosis
https://www.nature.com/articles/s41418-026-01742-5

In lung cancer cells, on creating nanoemulsions of CBD & THC for better bioavailability
Chemosensitizing CBD/THC nanoemulsions: Functional drug-delivery carriers for synergy, dose reduction, and apoptosis in lung cancer cells
https://www.sciencedirect.com/science/article/abs/pii/S1773224726003667

💊 Synthetic Cannabinoids & Hemp-Derived Cannabinoids 💊

On macrophages (white blood cells), the synthetic cannabinoid MDMB 4en-PINACA stimulated the release of anti-inflammatory cytokines
Immunomodulatory Activities of Synthetic Cannabinoid MDMB 4en-PINACA on the Inflammatory Activity of Mammalian Macrophages
https://journals.sagepub.com/doi/full/10.1177/1934578X261445167

In liver cells, a thesis project on the metabolism of THC analogues
Delta-9-tetrahydrocannabutol (Δ9-THCB), Delta-9-tetrahydrocannabihexol (Δ9-THCH), and Delta-9-tetrahydrocannabiphorol (Δ9-THCP): the Impact of Varying Alkyl Chain Length on Delta-9-tetrahydrocannabinol (Δ9-THC) Analog Metabolism
https://scholarscompass.vcu.edu/frsc_projects/132/

In flatworms, on using AI to profile the effects of synthetic cannabinoids
Artificial intelligence assisted behavioral profiling of synthetic cannabinoids in planarians
https://link.springer.com/article/10.1007/s11419-026-00769-0

🔬 Biochemical Discoveries & Research Tools 🔬

For activating the CB2 receptor, on finding 8 new drug families
Library docking for Cannabinoid-2 Receptor ligands
https://europepmc.org/article/pmc/pmc13015411

On using AI to find new cannabinoid drugs
Leveraging machine learning for selective cannabinoid ligand discovery: methods, challenges, and opportunities
https://www.tandfonline.com/doi/full/10.1080/17460441.2026.2661209

An analysis of the FAAH enzyme & its speed of breaking down anandamide
Enzyme Kinetics of FAAH
https://digitalcommons.liberty.edu/cgi/viewcontent.cgi?article=3070&context=research_symp

On the activity of the FAAH enzyme (which breaks down anandamide), CBC & CBG limited its activity via allosteric modulation
Analysis of the Effects of Phytocannabinoids Cannabichromene (CBC), Cannabidiol (CBD), and Cannabigerol (CBG) on the Enzyme FAAH
https://digitalcommons.liberty.edu/cgi/viewcontent.cgi?article=3075&context=research_symp

On using tocopherols to modulate the FAAH enzyme allosterically (binding not to the main binding site, but to a side binding site that changes how other molecules bind to the main binding site)
Allosteric Modulation of FAAH by Tocopherols
https://digitalcommons.liberty.edu/cgi/viewcontent.cgi?article=3064&context=research_symp

Thanks.
- lex

PS: For today’s jazz organ, “Brother” Jack McDuff’s ‘The Prestige Years’. Born in Illinois, McDuff began teaching himself the organ & the piano in the mid-‘50s. He came to the attention of the iconic Prestige Records & cut his first album for them in 1960. He soon formed his own band & things really took off when he hired the young but now famous guitarist George Benson, giving him his first big break. With his Hammond B-3 organ, McDuff was known for “rock-solid basslines and blues-drenched solos… balanced by clever, almost pianistic melodies”. He recorded 20+ albums with Prestige, including his biggest hit “Rock Candy” & then continued recording with Atlantic, Cadet & Blue Note across the ’60s & ’70s. As public interest in jazz waned, McDuff explored fusion & electronic keyboards. Even as his health faltered in the ‘90s, he never stopped exploring new styles & he still released 8 albums for Concord Jazz Records. In 2001, Brother Jack went to the great Sit-In in the Sky.

This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.
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Migraines, IBD, adolescent brain effects & horse doping

Lex Pelger WhiteWhaleCreations — Mon, 04 May 2026 13:28:48 GMT

Cannabinoids & The People,
or; Drugs & Drug Wars

🌟 #ThisWeek 🌟

(#hashtags for jumping to articles by searching for them with your browser)

CBD for inflammatory bowel disease
Adolescent cannabis use & negative neural effects (& my 24’ video on it)
Breakout sections: migraines, prenatal cannabinoid exposure, horse doping & treatments that use the ECS
CHS from delta-8 THC
What happens when you ask your AI about using cannabis or cancer? (#AIcancer)
Preclinical: CBDA for MS, CBD for cystitis, PEA for Alzheimer’s & CBD for lowering HIV & COVID transmission
Share your cannabis arrest story with the Marijuana Policy Project (#EndProhibition)
War on Drugs: reports from Miami in the 80s, Mexico in the 60s & Nepal in the 70s + Buddhists monks smuggling 200+ pounds
Harm Reduction: US health agency will no longer pay for fentanyl test strips

(Numbers for C&P#185: ~8k words, ~21 minutes reading time, 135 papers)

📌 Editor’s notes 📌:

Ticket contest for Cannabis Europa 2026! Sign up for one (or all) of the social media channel of Cannabis Europa, let me know & I’ll enter you into a raffle for a free ticket to their conference on May 26^th & 27^th in London. You can follow them on LinkedIn, Instagram, Facebook, X or YouTube.
It was another great year at ICBC in Berlin. You can watch their aftermovie here.
For aging with cannabis & CBD, I’m very pleased to share that Dr. Peter Grinspoon’s new book comes out this week: ‘Aging Well with Cannabis: Feel Better, Sleep Better, and Live Better with Marijuana and CBD’. He is an excellent educator on the cannabinoids & I believe using them for aging is one of the most important uses. But it can be tricky & complex so his clear explanations will be helpful to anyone who wants to help themselves or their aging relatives by using cannabis or CBD. To get a feel for his excellent vibe, listen to our interview on the Lex Files.
This Beltane season, I realized that I felt like the character of Jacob in the Bible who had to work 14 years to earn his 2 wives. I spent the last 7 years making this newsletter into a respected contribution to the cannabis community. So now I wish to spend the next 7 years making my cannabis graphic novels based on Moby Dick into a respected piece of artistic science writing. And in celebration of getting my next two chapters published, I put up a link to a free PDF of Chapters 1 & 2, including my Extracts section with dozens of quotes from history & world literature.

Hello everyone,
Welcome to the 185^th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news as well as the War on Drugs, harm reduction & other psychoactives. Support this work with a paid subscription or by buying me a coffee.

🤝 Sponsor 🤝: Cannabis Europa

Cannabis Europa will be the first major international gathering since US rescheduling aligned federal policy more closely with Europe’s medical frameworks, marking the start of a true transatlantic cannabis market. What sets this year apart is the level of leadership in the room. This is where senior executives, investors and policymakers come together to move beyond theory and define strategy. As the US and Europe begin to converge, Cannabis Europa provides a focused environment for those leading the industry to shape how capital, regulation and clinical standards evolve across both markets.

Contest & discount code:
Follow any of their social media accounts & let me know to enter the raffle for a free ticket: LinkedIn, Instagram, Facebook, X or YouTube.
And if you don’t win, you can save £74 with this discount code: SCHEDULE3

🎥 Lex’s new work 🎤

@CannabinoidsAndThePeople on YouTube, TikTok & LinkedIn
Canna-edu videos sponsored the National Cannabis Study (join & get paid $100 to talk about your use of our favorite plant)

Cannabis & Adolescent Brain Development (a 24’ on why I will encourage my kids to wait until they’re older)
Cannabis Use Disorder & Brain Recovery
Early Human Use of Cannabis: China Edition!
Poetic Cannabis Defense in Kenya

Canna-science Videos for CV Sciences on YT @CVSciencesInc & on TT @pluscbd
For 30% off their CBD, THC & PEA products, at pluscbdoil.com use the coupon code ‘LEX’

@LexPelgerAndHisBooks on TikTok, YouTube & Instagram:

And as always, at the bottom is the album of the week: Pete Fountain, King of the Clarinet

💖 Ways to support this work 💖

- Venmo: @Lex-Pelger

- PayPal: donate here

📣 A request to spread the word 📣

This newsletter only spreads by word of mouth, so please share to friends & colleagues.

🍃 BEST OF CANNABINOID SCIENCE 🍃

(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)

⚕️ Clinical ⚕️

For inflammatory bowel disease, a survey found that the predominant use of CBD was for anxiety, insomnia & pain
Cannabidiol Use in Inflammatory Bowel Disease: Insights From a Gastroenterology Outpatient Population
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jgh3.70402

On CBD for psychotic disorders, this meta-analysis of 8 trials found that an average daily dose of 800 mg per day caused no statistically significant improvement to psychosis symptoms
Cannabidiol for psychotic disorders: A meta-analysis of randomized controlled trials
https://journals.sagepub.com/doi/full/10.1177/02698811261430501

For sleep & nicotine/cannabis co-use, a review of 6 studies found that half reported poor sleep & half reported no effect
Nicotine and Cannabis Co-Use and Sleep-Related Outcomes in Adults: a Narrative Review and Implications
https://link.springer.com/article/10.1007/s40429-026-00738-y

When the major AI chatbots were asked about cannabis for cancer, while they made some misleading or inaccurate statements, they overall had high accuracy & comprehensiveness scores, with ChatGPT doing the best (#AIcancer)
Chatbot Responses to Frequently Asked Questions about Cannabis and Its Use for Cancer Symptoms
https://www.jpsmjournal.com/article/S0885-3924(26)00151-X/abstract

Migraines

For migraines, this data from the UK Medical Cannabis Registry found that the initiation of cannabis-based medicine led to improvements over the next 2 years
UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Migraine
https://onlinelibrary.wiley.com/doi/abs/10.1002/brb3.71323

For drug-resistant migraines, a case report of a 1:1 THC:CBD oil reducing headache days by half, lowering pain intensity, improving sleep quality & enhancing quality of life
Use of Therapeutic Cannabis Oil for Drug-Resistant Migraine: A Case Report
https://journals.sagepub.com/doi/full/10.1177/27683192261437643

For menstrual migraines, a combination of PEA & phycocyanin (a pigment-protein complex from bacteria) reduced migraine severity, duration, painkiller usage & the associated symptoms including nausea, vomiting & photophobia
Effectiveness of an Oral Supplementation of Phycocyanin and Palmitoylethanolamide for a Short-Term Prophylaxis of Menstrual Migraine: A Retrospective Observational Study
https://www.mdpi.com/2227-9059/14/4/865

In a mouse model of post-traumatic headache, the brain upregulated genes for enzymes that degrade the endocannabinoids
Distribution and subacute modulation of endocannabinoid metabolizing enzymes in the trigeminal complex and midbrain in a pre-clinical model of post-traumatic headache
https://link.springer.com/article/10.1186/s10194-026-02356-5

Prenatal Cannabinoid Exposure

In children exposed to prenatal cannabis and/or tobacco, this cohort study found that they had no significant impairments to cognitive or language development
The association between prenatal exposure to cannabis with and without tobacco and early cognitive and language development in a sample of polysubstance-exposed children
https://www.sciencedirect.com/science/article/pii/S0378378226000745

For low levels of prenatal exposure, there was little evidence for later effects on cognition as adolescents
Associations of Low‐Level Prenatal Alcohol and Cannabis Exposure With Adolescent Cognitive Trajectories
https://onlinelibrary.wiley.com/doi/pdf/10.1111/acer.70297

In pregnant mice, cannabis smoke reduced fetal weight, increased placental weight & altered placental morphology
Marijuana smoking during pregnancy alters placenta morphology in BALB/c mice
https://www.sciencedirect.com/science/article/pii/S014340042600113X

Horse Doping

In sports horses, on how CBD & its metabolites moved through their systems
Pharmacokinetics of Cannabidiol and its Metabolites for the Definition of Ineffective Plasma and Urinary Concentrations in Biological Liquids of Sport Horses
https://www.ijvets.com/pdf-files/25-334.pdf

For the doping of horses, a review on detecting the synthetic cannabinoids & an analysis of their effects
Analytical Challenges and Emerging Detection Strategies of Synthetic Cannabinoids in Horse Doping Control
https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/bmc.70432

📑 Reviews 📑

On cannabinoids for dermatology, this review covered the evidence for many diseases & the barriers to clinical use (great charts!)
Cannabinoids for Dermatological Applications: Mechanistic Insights, Clinical Evidence, and Emerging Nanotechnology-Enabled Delivery Strategies
https://www.mdpi.com/1999-4923/18/4/469

For wound healing & bone regeneration, a review of the mechanisms used by CBD (nice charts)
Pharmacological Insights into Cannabidiol for Wound Healing and Bone Regeneration
https://pubs.acs.org/doi/full/10.1021/acsomega.5c13259

In young people with autism, a rather negative review of 12 studies found the most improvement from a whole-plant 20:1 CBD:THC formula
Cannabinoid-based interventions for behavioral outcomes in children and adolescents with autism spectrum disorder: A systematic review of safety and effectiveness
https://www.sciencedirect.com/science/article/abs/pii/S0278584626000941

For motor control disorders, a review on the location of cannabinoid receptors in key motor pathways & the growing importance of the CB1 & CB2 receptors (nice charts)
Cannabinoids in Motor Control: From Receptor Distribution to Motor Disorders
https://www.mdpi.com/2227-9059/14/4/844

For the muscle-relaxing effects of cannabinoids, this review examined the potential benefits for inflammation, pain & arthritis
Cannabis sativa Linn.: A Medicinal Plant with Promising Muscle Relaxant-related Constituents
https://journals.sagepub.com/doi/full/10.1177/22313354261436144

For diabetic heart disease, a review on the benefits of CBD for inflammation, oxidative stress & scarring, but the limited clinical evidence
Cannabidiol and diabetic heart disease: Mechanistic evidence and translational challenges
https://www.sciencedirect.com/science/article/pii/S0753332226003872

For epilepsy, MS & depression, a review on the benefits of CBD
Emerging Cannabidiol Research in Neurological Disorders: Insights into Epilepsy, Multiple Sclerosis, and Depression
https://terra-docs.s3.us-east-2.amazonaws.com/IJHSR/Articles/volume8-issue3/IJHSR_2026_83_15.pdf

For neuropathic pain, this review found cannabinoids not superior to placebo & with only modest painkilling benefits as well as sleep quality & opioid sparing [Portuguese]
USO DE CANABINÓIDES SINTÉTICOS E FITOCANABINÓIDES NO TRATAMENTO DA DOR NEUROPÁTICA: UMA REVISÃO BASEADA EM ENSAIOS CLÍNICOS RANDOMIZADOS
https://periodicorease.pro.br/rease/article/view/25140
Yes, but few people are suggesting to use cannabinoids as your only treatment for something as severe & complex as neuropathic pain. They are a helpful adjunct to other treatments that somewhat help with pain & are well known to benefit other symptoms around the pain as well.

⚠️ Harms ⚠️

For adolescent cannabis use, a review of 36 studies on the effects of brain development found “as well as mixed cognitive findings reduced prefrontal cortical and hippocampal/amygdala volumes, accelerated cortical thinning in longitudinal studies, and impaired white matter connectivity correlating with initiation age” (here’s my deep-dive 24’ video on this review)
How adolescent cannabis use reshapes the developing brain — a systematic review
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1822300/full
“Long-term associations included educational difficulties, mental health problems, and functional impairment, though causal relationships remained unclear.”

In a New York City hospital after cannabis legalization, children had increased exposure to cannabis & cannabis edibles, though most cases were mild & were discharged
Changes in Cannabis-Related Pediatric Emergency Visits following Recreational Marijuana Legalization in a New York City Hospital: A Retrospective Study
https://www.researchgate.net/publication/400633245_Changes_in_Cannabis-Related_Pediatric_Emergency_Visits_following_Recreational_Marijuana_Legalization_in_a_New_York_City_Hospital_A_Retrospective_Study

For first-episode psychosis, Swedish public health data found that those with cannabis use disorder or cannabis-induced psychosis were less likely to have a diagnosis of schizophrenia in the first 2 years but more likely to have a greater burden of inpatient treatment as well as elevated risks of hospitalization for psychosis & death
Comparative Clinical Trajectories Across Cannabis-Related and Nonsubstance-Related Psychoses
https://europepmc.org/article/med/41952346

In cannabis-induced psychosis, a review of 33 studies on the distinct clinical features found the strongest predictor of poor outcomes to be continued cannabis use
Multi-dimensional recovery trajectories in cannabis-induced psychosis: A systematic review examining symptomatic, functional, cognitive, and subjective outcomes
https://www.sciencedirect.com/science/article/abs/pii/S1876201826001486

For major depressive disorder, data from the UK Biobank found cannabis use associated with a 27% increase in the odds of depression
Association between cannabis use and major depressive disorder: a population-based cross-sectional study
https://link.springer.com/article/10.1186/s42238-026-00396-x

For delta-8 THC causing cannabinoid hyperemesis syndrome (CHS), a case report of someone who stopped smoking cannabis 5 months ago because of a CHS diagnosis but whose daily use of delta-8 THC continued her symptoms
Cannabinoid hyperemesis syndrome from delta-8 tetrahydrocannabinol after discontinuing regular cannabis use
https://pulmonarychronicles.com/index.php/SWJM/article/view/1623

In the eyes of cannabis users, a Sudanese survey found an increased risk of visual disturbances
Self-reported Visual Function After Non-medical Cannabis Use: A Cross-sectional Survey
https://kneopen.com/sjms/article/view/19228/33434/

For the post-mortem analysis of synthetic cannabinoids, 3 fatal case reports on ADB-BUTINACA & its toxicological significance score
Synthetic Cannabinoids in Human Post-Mortem Samples – ADB-BUTINACA and Metabolites in Three Fatalities
https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2026.1826767/abstract

🐁 Preclinical 🐁

In a mouse model of multiple sclerosis, CBDA improved neurological scores & increase the levels of TNFα (important for immunomodulation)
Anti-Neuroinflammatory Cannabinoid Acids as a New Therapeutic Approach for Multiple Sclerosis
https://www.mdpi.com/1420-3049/31/7/1227

In a mouse model of cystitis in the lower urinary tract, CBD promoted the restoration of damaged structures, improved the integrity of the blood-urine barrier & reduced inflammation
CBD Promotes Structural and Functional Epithelial Restoration and Alleviates Inflammation in a Mouse Model of Interstitial Cystitis
https://www.mdpi.com/1999-4923/18/4/458

In mice taking THC, CBD modulated the changes to motor activity & hypothermia with gendered effects
Cannabidiol dose modulates behavioral response to acute and repeated administration of Δ9-Tetrahydrocannabinol by strain and sex
https://pubmed.ncbi.nlm.nih.gov/41959067/

In a mouse model of Alzheimer’s disease, an infusion of PEA restored motivation-driven behavior via upregulated levels of BDNF (a key brain growth factor) & the regulator of genetic transcription PPAR-α
Sustained Palmitoylethanolamide Infusion Restores Incentive Motivation and Synaptic Plasticity in the Tg2576 Mouse Model of Alzheimer’s Disease
https://www.mdpi.com/2073-4409/15/8/669

In mucosal cells exposed to HIV, CBD inhibited infection
Cannabidiol prevents mucosal HIV-1 transmission by targeting Langerhans cells, dendritic cells, macrophages and T-cells
https://www.sciencedirect.com/science/article/pii/S1933021926000309

For blocking the virus that causes COVID, a computer analysis found that CBD & CBN had the most favorable binding
Molecular Dynamics and Solvated Interaction Energy Prioritize Cannabidiol and Cannabinol as Variant-Spanning SARS-CoV-2 RBD–ACE2 Interface Blockers
https://www.mdpi.com/1420-3049/31/8/1253

Treatments using the ECS / Cannabinoid synergy

Some nice additions to our list of drugs that cause their help via the endocannabinoid system or synergize with the cannabinoids…

In a rat & tissue model of strokes, the ability of propofol to cause neuroprotection & increase antioxidant levels was via the CB1 receptor & the release of the endocannabinoids anandamide & 2-AG
Propofol Attenuates Brain Ischemic Injury Through the Cannabinoid Type 1 (CB1) Receptor
https://assets.cureus.com/uploads/original_article/pdf/477243/20260408-52515-vpl68y.pdf

In a mouse model of the brain disorder spinocerebellar ataxia, long-term treatment with an NMDA receptor blocker appears to work partially via the endocannabinoids acting retrogradely (against the usual flow of brain signaling) to lower the release of glutamate (the brain’s most common excitatory neurotransmitter)
Long term administration of selective NMDA GluN2B receptor blocker Ro25-6981 attenuates neurodegeneration in mouse model of spinocerebellar ataxia type 1 (SCA1)
https://www.nature.com/articles/s41420-026-03120-z_reference.pdf

In a mouse model of arthritis, the combination of CBD & methotrexate had synergistic effects for lowering joint swelling, inflammation & bone erosion as well as lessening methotrexate’s testicular toxicity & sperm failure
Cannabidiol synergizes with methotrexate to attenuate rheumatoid arthritis via STAT3/NF-κB signalling-mediated M1 macrophage polarization
https://www.sciencedirect.com/science/article/abs/pii/S1567576926004728

In a rat model of a high-fat diet, the usual cognitive impairment & memory problems were attenuated by the addition of CBD via downregulation of GFAP/ACHE pathway
Neurological effects of cannabidiol in olanzapine/high-fat diet co-treated adult male Wistar rats
https://www.tandfonline.com/doi/abs/10.1080/13813455.2026.2657420

For cardamomin (a chalcone found in ginger & other plants), a computer & mouse analysis found that it bound to both the CB1 & CB2 receptors to cause painkilling effects
Receptor-Selective Modulation of Cannabinoid Signaling by Cardamonin: Integrating Molecular Dynamics, Free Energy Calculations, and Behavioral Validation
https://pubs.acs.org/doi/full/10.1021/acsomega.5c10026

🆕 Novel Studies 🆕

(a grab bag section for cool & new stuff)

For uterine disorders, this thesis project examined the interplay of the endocannabinoids & sphingosine 1-phosphate (S1P, an important lipid signaling system)
Role of Sphingosine 1-phosphate Signalling and Endocannabinoids System in Uterine Disorders: Endometriosis, Adenomyosis, Uterine fibroids
https://flore.unifi.it/bitstream/2158/1463532/1/Tesi-%20Maryam%20Raeispour.pdf

For cis versions of THC (an opposite molecular “handedness” to the much more common trans versions), an analysis found that its low levels in the cannabis plant do not appear to be chemically derived from other cannabinoids, though the CBCA synthase enzyme might be involved
Targeted phytocannabinomics provides new insights into the biosynthetic origin of cis-Δ⁹-THCA in Cannabis sativa L.
https://www.sciencedirect.com/science/article/pii/S0731708526001780

📰 US Headlines & Fav Articles

The US Department of Justice moved state-legal medical cannabis & FDA-approved cannabis products to Schedule III, which is mostly a win on taxes for the big multi-state medical operators, a requirement (?) for DEA registration for all medical operators, an opening for the possible import & export of medical cannabis, increased researcher access to a wider array of cannabis products & eased FDA processes for pharmaceutical companies looking for cannabis product approval
https://www.justice.gov/opa/pr/justice-department-places-fda-approved-marijuana-products-and-products-containing-marijuana
https://www.marijuanamoment.net/federal-marijuana-rescheduling-will-end-discrimination-in-housing-healthcare-and-employment-for-medical-cannabis-patients-op-ed/
https://cannabismusings.substack.com/p/cannabis-musings-april-23-2026
https://harris-sliwoski.com/cannalawblog/the-u-s-opens-its-medical-marijuana-market-to-global-trade-for-now-adult-use-rescheduling-on-deck/
To be clear, this means no changes for state-legal adult use companies & no effects on synthetic THC (still Schedule 1) & hemp/hemp-derived intoxicating cannabinoids (still regulated under the Farm Bill).
President Trump said of the order, “A lot of people are suffering from big problems, which this [medical cannabis] seems to be the best answer.” Relatedly, Newsweek had an article entitled, ‘Is Donald Trump the Drug President?’ And an old rule of thumb in journalism is that if a headline ends in a question mark, the answer to that question is no.

The IRS declared that cannabis industry workers will not be eligible under the new “No Tax on Tips” law until cannabis is federally legalized
https://www.marijuanamoment.net/marijuana-budtenders-could-qualify-for-no-tax-on-tips-irs-says-but-only-after-federal-legalization/

A US airman overturned his cannabis conviction by arguing that his 4 failed drug tests were from federally legal hemp
https://cannabislaw.report/usa-military-court-overturns-conviction-in-hemp-related-drug-case/

In Oregon, hospice & other health facilities will now allow medical cannabis use
https://www.marijuanamoment.net/oregon-governor-signs-bill-to-allow-medical-marijuana-use-in-hospices-and-other-health-facilities/

In Virginia, medical use now allowed in hospitals & the parental rights of cannabis users now protected
https://www.marijuanamoment.net/virginia-governor-signs-bills-to-protect-marijuana-users-parental-rights-and-allow-medical-use-in-hospitals/

In Maryland, veterinarians who recommend medical cannabis to animals will have legal protections from the state regulatory board
https://www.marijuanamoment.net/maryland-governor-signs-bills-to-protect-veterinarians-who-recommend-medical-marijuana-for-animals/
And off-duty firefighters & rescue workers now allowed to use medical cannabis
https://www.marijuanamoment.net/maryland-governor-signs-bill-to-let-firefighters-and-rescue-workers-use-medical-marijuana-off-duty-without-being-punished-for-it/

🌐 International Updates 🌐

In Ireland, a review of their medical cannabis program was launched after it was revealed that less than 100 patients have been approved in the 5 years since launch
https://cannabislaw.report/five-years-74-patients-ireland-moves-forward-with-review-of-its-failing-medical-cannabis-programme/

In France, the food authorities relaunched their war on CBD products
https://www.newsweed.fr/dgal-relance-guerre-produits-cbd/

In the UK, an undercover BBC report found mini-marts selling cocaine, cannabis & prescription drugs
https://www.bbc.com/news/articles/c62l429w2pko

In Botswana, a hemp pilot project launched
https://cannabislaw.report/article-botswana-advances-hemp-industry-with-pilot-projects-ramps-up-investor-support/

⚖️ Business, Laws & Education ⚖️

One of our favorite cannabis news platforms, Cultivated Media, was debanked by those spineless weasels at Chase
https://cannabislaw.report/chase-debanks-cultivated-media-unsurprisingly-offers-no-explanation/
They did the same thing to me last year after they realized that I was making cannabis education videos on TikTok.

J.P Morgan forbid the custody of US cannabis stocks
https://toddharrison.substack.com/p/count-de-monet

In Canada, MasterCard just doubled their cost for cannabis businesses because of ‘high-risk’ & the retail cannabis Council of Ontario is organizing a boycott
https://www.linkedin.com/posts/retail-cannabis-council-of-ontario_mastercard-doubles-fees-for-cannabis-retailers-activity-7448088707255042048-Sg9Z/

The estate of Bob Marley sued Tilray for using an empty corporate entity to avoid paying royalties & cheating them out of $11.3 M
https://www.blackenterprise.com/bob-marley-estate-sues-tilray-brand-cannabis-company-for-11-3m/

In Minnesota, Target got hemp THC drinks licenses for all of its 72 stores
https://www.marijuanamoment.net/target-expands-involvement-in-hemp-thc-drinks-market-with-72-new-licenses-in-minnesota/

For the effects of US cannabis taxation, a review of 5 studies found quite mixed results, though policymakers saw taxes as an effective public health tool while cannabis users said it was an important factor in their purchase decisions
Limited Evidence on Cannabis Taxation Effects in the United States: A Rapid Review of Use, Purchasing, and Risk Perceptions
https://www.jsad.com/doi/abs/10.15288/jsad.25-00400

In Australia, an analysis of their cannabis policies since 1967
The evolution of Australian cannabis policies, 1967 to 2024
https://onlinelibrary.wiley.com/doi/pdf/10.1111/add.70414

For sustainable development, a South African review of 180 studies on the potential of cannabis
A Comprehensive Review on the Production, Cultural, and Medicinal Applications of Cannabis Plant for Sustainable Economic Development
https://journals.nasspublishing.com/index.php/rwae/article/view/2570

In 3 states with different cannabis laws, an analysis of CBD sales at retail locations found a host of prohibited claims
Health claims about cannabidiol (CBD) at the point-of-sale in three U.S. states with disparate cannabis policies
https://www.sciencedirect.com/science/article/pii/S2211335526001002

🚓 The War on Drugs 🚓

On cannabis arrests in the US, the numbers are down, but there were still 200k arrests in 2025 according to a new report by the Marijuana Policy Project
https://www.marijuanamoment.net/new-marijuana-report-shows-arrests-are-plummeting-as-legalization-spreads-but-criminalized-states-still-send-thousands-to-jail-each-year/
And if you’ve been arrested for cannabis, share your story with the Marijuana Policy Project for possible inclusion in the report about the ongoing harms of Prohibition (#EndProhibition)
https://www.marijuanamoment.net/marijuana-activist-group-asks-people-to-share-their-arrest-stories-to-show-the-true-impact-of-criminalization/

In the eastern Pacific, another lethal US strike on a suspected drug-trafficking vessel killed 2
https://www.aol.com/news/us-military-kills-two-suspected-035740207.html

To the UN, a report on using narco-terrorism to justify abuse by the International Drug Policy Consortium & supporting organizations
https://idpc.net/publications/2026/3/when-narcoterrorism-justifies-abuse-civil-society-submission-to-the-un-high-commissioner-for

In Mexico, a governor & other senior officials of Sinaloa charged by US prosecutors for conspiring with the Sinaloa cartel
https://www.nbcnews.com/news/us-news/mexican-governor-officials-charged-conspiring-sinaloa-cartel-smuggle-d-rcna342783
https://www.nytimes.com/2026/05/02/world/americas/mexico-governor-corruption-ruben-rocha.html
And an investigation into the death of 2 CIA officials in a car crash returning from an operation to destroy illegal drug labs in Chihuahua, apparently without the knowledge of Mexican senior federal officials
https://www.bbc.com/news/articles/cx2491we011o
https://www.bbc.com/news/articles/c86expy881qo

On Miami in the 80s, on the drug trafficking & the militarization of the War on Drugs
Paradise Lost? Miami and Militarization in the War on Drugs
https://www.journals.uchicago.edu/doi/abs/10.1086/740074

In the southern Mexican state of Guerrero during the ‘60s & ‘70s, on the rural guerrilla movements & rise in illicit drug cultivation leading to a more militarized policing of rural Mexican drugs
From Bandit Hunting to a War Against “Social Poisoners”: Counterinsurgency as Drug War and Drug War as Counterinsurgency in 1960s–1970s Southern Mexico
https://www.journals.uchicago.edu/doi/abs/10.1086/739586

In the Maoist conflict of Western Nepal, a thesis project on the role of the 1976 prohibition of cannabis cultivation
PROHIBITION ON MARIJUANA CULTIVATION AND ITS ROLE IN SPARKING THE MAOIST CONFLICT IN WESTERN NEPAL: A SOCIOLOGICAL INQUIRY
https://elibrary.tucl.edu.np/JQ99OgQIizUxyjI9nB0on9OyLkqsGIf4/api/core/bitstreams/02352e48-2543-463a-9ced-37c9ef55e44a/content

For Nixon’s short-lived Narcotics Traffickers Tax Program (NTP), an analysis of its experiment to punish drug kingpins, similar to the Prohibition-era tactics used against Al Capone such as income tax & financial kingpin laws
“This Is Al Capone Revisited with a Vengeance”: The Internal Revenue Service’s Narcotics Traffickers Tax Program
https://www.journals.uchicago.edu/doi/abs/10.1086/739731

In Colombia’s illicit crop substitution program, a thesis project on the partial success
The Distance to Legality: The Success and Failure of Illicit Crop Substitution in Post-Accord Colombia. Regional Economics
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6538260

In Singapore, a man executed for importing 1 kg of cannabis
https://deathpenaltyinfo.org/singapore-executes-man-for-cannabis-importation-amid-rising-drug-related-executions
And in China, a Frenchman executed for a 2010 at drug trafficking charge
https://www.channelnewsasia.com/east-asia/china-execute-frenchman-drug-trafficking-6037466
And in Iraq, 5 drug traffickers sentenced to death
https://shafaq.com/en/Security/Baghdad-court-mandates-death-for-five-drug-traffickers
And in Kuwait, death sentences for 3 Iranians upheld for smuggling 120 kg of hashish & 10k pills
https://cannabislaw.report/kuwait-appeal-court-upholds-death-sentences-for-three-iranians-in-hashish-smuggling-case/
And in Malaysia, an Indonesian grandmother freed from death row after 15 years for drug trafficking
https://www.the-independent.com/asia/southeast-asia/indonesia-malaysia-grandmother-drug-taficking-b2951799.html
And in Nigeria, a man gets 7 years for selling cannabis to the terrorist group Boko Haram
https://cannabislaw.report/nigeria-man-jailed-seven-years-for-selling-indian-hemp-cigarette-to-boko-haram-terrorists/

In Brazil, 48 tons of cannabis seized in record busted by a drug dog named Hulk
https://cannabislaw.report/brazil-police-dog-named-hulk-sniffs-out-48-tons-of-cannabis-in-record-bust/

In Uzbekistan, 191 kg of hashish seized at Afghani border
https://cannabislaw.report/uzbekistan-seizes-191-kg-of-hashish-in-smuggling-attempt-from-afghanistan/

In San Francisco’s East Bay, 24 detained & 20k cannabis plants seized from an illegal operation
https://cannabislaw.report/20000-marijuana-plants-seized-24-detained-in-raids-of-illegal-east-bay-cannabis-operations/

In the UK, 3 Albanians arrested at an industrial grow with 889 cannabis plants
https://cannabislaw.report/man-grinning-from-ear-to-ear-with-huge-weed-stash-hes-just-harvested-busted-by-manchester-police/

The US Coast Guard seized 3.8k pounds of cocaine in international waters of the eastern Pacific
https://www.aol.com/news/u-coast-guard-seizes-over-095243758.html

In New Jersey, a man with illegal cannabis vending machines was making $20k per day
https://cannabislaw.report/new-jersey-illegal-cannabis-vending-machines-earned-20k-per-day-for-nj-man-prosecutor-says/

In Sri Lanka, 22 Buddhist monks arrested with 242 pounds of cannabis
https://www.cbsnews.com/news/monks-arrested-sri-lanka-airport-record-drug-bust-kush/

In Italy, two members of the Hare Krishna movement were acquitted on charges of cannabis cultivation & possession because of their defense of religious use linked to the worship of the Hindu god Shiva
https://cannabislaw.report/italy-bologna-court-of-appeal-acquits-two-of-the-hare-krishna-movement-who-had-been-convicted-in-the-first-instance-in-january-2023-on-charges-of-cultivation-and-possession-of-cannab/

🛡️ Harm Reduction News 🛡️

The US Substance Abuse and Mental Health Services Administration (SAMHSA) said they will no longer pay for fentanyl or other drug testing strips
https://www.nytimes.com/2026/04/27/health/trump-fentanyl-test-strips.html
https://filtermag.org/samhsa-funding-fentanyl-test-strips-overdose-hotlines/
Let me be clear that I find this move abhorrent.

In Ontario, funding pulled for the last provincially supported supervised consumption site
https://www.sudbury.com/local-news/ontario-pulls-funding-for-last-provincially-supported-supervised-consumption-site-12127180

In Minneapolis, the City Council legalized drug paraphernalia
https://www.startribune.com/minneapolis-city-council-drug-paraphernalia-barnette-evictions-pause/601792078

Eastern Shoshone Tribal Health launched harm reduction vending machines
https://www.wyomingpublicmedia.org/open-spaces/2026-03-20/eastern-shoshone-tribal-health-launches-harm-reduction-vending-machines

Harm Reduction Research

For treating opioid use disorder (OUD), this first national-scale multi-healthcare organization analysis found that buprenorphine, methadone & psychotherapy were all associated with improved OUD remission, with the strongest positive effects from the combination of buprenorphine & psychotherapy, while prescriptions for a benzodiazepine had a negative association
Real-world effectiveness of medication-assisted treatment and psychotherapy for opioid use disorder: a national multi–health care organization analysis
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1741907/full

For youth with opioid use disorder, an editorial calling for expanded access to take-home naloxone
A call to action: expanding take-home naloxone availability for paediatric patients
https://academic.oup.com/pch/advance-article-abstract/doi/10.1093/pch/pxag011/8626267

For a mobile health unit providing medications for opioid use disorder, interviews on the benefits of reduced barriers as well as the challenges
A lifeline on wheels: perspectives of stakeholders on the implementation and impact of a mobile medications for opioid use disorder unit
https://link.springer.com/article/10.1186/s13722-026-00664-4

For overdose hotlines & apps, a survey on the barriers to use among people who use substances
Investigating the barriers to uptake and utilization of overdose response hotlines and apps: A study based on data from a national survey
https://journals.sagepub.com/doi/pdf/10.1177/20552076261440969

For substance use disorders, a review of 15 trials found that family engagement in substance use treatment was associated with favorable outcomes
Efficacy of Family-based Interventions in Addressing Substance Use Disorders: A Systematic Review on Randomized Controlled Trials
https://journals.sagepub.com/doi/full/10.1177/02537176261435440

For people using crack-cocaine, a review of 24 studies on the most helpful harm reduction interventions
Harm reduction progams and interventions for equity -deserving populations who use crack -cocaine. A scoping review
https://karger.com/ear/article-pdf/doi/10.1159/000551848/4526194/000551848.pdf

🍄 Psychoactives, Psychedelics & Plant Medicines 🍄

Trump signed an executive order to accelerate the legal access to psychedelics & provided a large funding boost for ibogaine
https://www.marijuanamoment.net/trump-signs-order-to-accelerate-legal-access-to-psychedelics-for-patients-with-mental-health-conditions/
https://www.theguardian.com/us-news/2026/apr/24/trump-psychedelic-medication-order
https://www.ecstaticintegration.org/p/sounds-great-want-fda-approval-lets
With pushback by friend of the newsletter Dimitri Mugianis
https://www.statnews.com/2026/04/20/trump-executive-order-psychedelics-republicans-veterans-ibogaine/
Apparently this executive order came about only because Trump was trying to placate Joe Rogan because of the his opposition to the war in Iran. So Trump threw him a bone with this executive order that doesn’t actually do much to speed up psychedelic access. Besides the promised $50M for ibogaine research, not much else will change much because of this executive order.

The Inter-Tribal Council (ITC) of the Five Civilized Tribes passed a resolution supporting ibogaine for addiction & trauma
https://www.chickasaw.net/News/Press-Releases/Release/Inter-Tribal-Council-passes-a-resolution-in-suppor-55805.aspx

In France, they became the first country to approve ketamine for severe suicidal ideation
https://ansm.sante.fr/actualites/decision-du-09-03-2026-etablissant-un-cpc-des-medicaments-ketamine-panpharma-10-mg-ml-solution-injectable-i-v-i-m-ketamine-renaudin-10-mg-ml-solution-injectable

‘How the grandson of Kazakhstan’s dictator became a psychedelic guru’: Nurali of Spark of Light
https://www.ecstaticintegration.org/p/how-the-grandson-of-kazakhstans-dictator

For psychosis & ashwagandha, a case report of an ashwagandha supplement causing visual hallucinations
Recurrent psychotic episodes in a patient taking Withania somnifera (Ashwagandha): A case report on ashwagandha-induced hallucination
https://jcimcr.org/pdfs/JCIMCR-v7-3967.pdf

Psychedelics & MDMA

For extended difficulties after a psychedelic experience, a global survey on the symptoms & demographics
Extended difficulties after psychedelic experiences: Prevalence and associations in a global, multilingual sample
https://assets-eu.researchsquare.com/files/rs-9304959/v1/01c4a0d1-df5e-4ca3-af46-11b264ee47c5.pdf

On DMT for substance misuse, a meta-analysis found that it combined well with psychotherapy for reducing drug use
Efficacy of N, N-dimethyltryptamine (DMT) psychedelic therapy for substance misuse: A systematic review and meta-analysis
https://journals.sagepub.com/doi/pdf/10.1177/02698811261430518

For death anxiety in terminal patients, a review of the efficacy of psilocybin
Efficacy of psilocybin on death anxiety in terminal patients: a narrative review
https://www.tandfonline.com/doi/full/10.1080/09699260.2026.2657096

For ADHD, a review on the use of psychedelics
The Use of Psychedelics in the Treatment of Adult ADHD: A Systematic and Mechanistic Review
https://www.mdpi.com/1422-0067/27/8/3453

In people using MDMA, a review of the subjective & neurocognitive effects
Subjective and neurocognitive profiling of clinical doses of 3,4-methylenedioxymethamphetamine (MDMA) in healthy volunteers: implications for therapeutic use
https://www.nature.com/articles/s41380-026-03602-7

For ibogaine, a review of its safety profile
Ibogaine Side Effects: Comprehensive Clinical Safety Profile
https://react19.org/images/pdfs/10ibogainesideeffects.pdf

Ketamine

In people with PTSD, a review of ketamine found that a single infusion reduced symptoms within 24 hours but that immediate post-trauma administration may worsen dissociative symptoms & acute stress responses
The impact of ketamine on posttraumatic stress disorder (PTSD) symptomatology in trauma-exposed populations: a narrative review
https://www.jtraumainj.org/journal/view.php?number=1403

Kratom

For kratom, a review of its folk medicine history, potential clinical uses & toxicology
Kratom (Mitragyna speciosa Korth.): ethnopharmacology, phytochemistry, therapeutic potential, and regulatory perspectives
https://www.sciencedirect.com/science/article/pii/S2667031326000321

For reports of kratom to the US poison centers, there was a significant increase over the last 10 years with ~1300 cases of life-threatening symptoms & 219 deaths (though only 40 of those involved kratom alone)
Kratom exposure cases reported to United States Poison Centers: 2016–July 2025
https://www.sciencedirect.com/science/article/abs/pii/S0735675726001701

For kratom changing skin color (hyperpigmentation), two case reports of brown-gray patches
Kratom‐Induced Hyperpigmentation: An Emerging Clinicopathologic Pattern
https://onlinelibrary.wiley.com/doi/abs/10.1111/cup.70087

In a rat model of neuropathic pain, paracetamol synergized with kratom leaf extract to reduce pain & inflammation
Synergistic Analgesic and Anti-Inflammatory Effects of Kratom (Mitragyna speciosa) Leaf Extract as an Adjuvant to Paracetamol in a Rat Neuropathic Pain Model
https://scholar.unair.ac.id/en/publications/synergistic-analgesic-anti-inflammatory-effects-of-kratom-mit/

Cathinones

For the novel synthetic cathinone 2-methylmethcathinone (2-MMC), case reports from the French Alps on toxicology & 5 deaths
Emergence of 2-MMC in the French Alps: description of 13 clinical and forensic toxicology cases
https://link.springer.com/article/10.1007/s00414-026-03791-4

🍃 The Plant & its Products 🍃

According to the USDA, American farmers grew $739M of hemp last year
https://www.marijuanamoment.net/american-farmers-grew-739-million-worth-of-legal-hemp-last-year-new-usda-report-shows/

🌱 Growing 🌱

For hemp seed germination, moderate levels of plasma priming enhanced germination & physiological responses
Plasma-based treatments regulate seed germination in Cannabis sativa via oxidative status modulation and transcriptional changes
https://www.sciencedirect.com/science/article/pii/S0981942826002548

For light, on the effects of far-red timing on morphology & flower induction
Optimizing Light Spectra for Cannabis: Effects of End-of-Day and Continuous Far-Red on Plant Morphology and Flower Induction
https://www.mdpi.com/2311-7524/12/4/456

On fertilizing with a combination of NPK & the long-chain alcohol triacontanol (TRIA), on the mixed effect on yield & terpene levels
Altered NPK Fertigation With Triacontanol Supplementation Indicates Promising Improvements to Cannabis Flower Yield and Volatile Composition
https://rsnz.onlinelibrary.wiley.com/doi/pdf/10.1002/nzc2.70167

For hemp grown in Russia, the influence of seeding rate on cannabinoid levels
The influence of seeding rate on the accumulation of cannabinoids in hemp in the southern forest-steppe of the Republic of Bashkortostan, Russia
https://www.e3s-conferences.org/articles/e3sconf/pdf/2026/21/e3sconf_aees2026_01013.pdf

⚙️ Extracting, Analyzing & Formulating ⚙️

For cannabis edibles, “fast-acting edibles” (using microencapsulation) hit their maximum blood levels an average of 30 minutes earlier than standard edibles
Pharmacokinetic Differences Between Fast-Acting, Standard, and Placebo Cannabis Edibles
https://journals.sagepub.com/doi/full/10.1177/25785125261441366

For cannabis seed oil produced in Morocco, an environmental life cycle assessment of sustainability on industrial versus artisanal production
Life Cycle Management of Moroccan Cannabis Seed Oil: A Global Approach Integrating ISO Standards for Sustainable Production
https://www.mdpi.com/2673-4672/6/2/22

For detecting contaminants in cannabis products, a review of the analytical methods & the regulatory oversight
Cannabis Products and Contaminant Detection: Critical Review of Regulatory Oversight and Analytical Methodologies
https://journals.sagepub.com/doi/full/10.1177/25785125261439008

In cannabis oils, on different techniques for benchtop & portable cannabinoid quantification
Quantification of cannabinoids in medicinal Cannabis oils using bench-top mid-infrared (MIR), near-infrared (NIR), and portable NIR spectroscopy with chemometric analysis
https://www.sciencedirect.com/science/article/abs/pii/S1386142526004634

In commercial oils, the development of a portable photometer for quantifying CBD levels
On-site colorimetric quantification of cannabidiol in commercial oils using a portable photometer
https://www.sciencedirect.com/science/article/abs/pii/S2468170926000214

For cannabinoid stability, AI analysis on the effects of water
Deep eutectic solvents incorporating cannabinoids: The influence of water on stability
https://www.sciencedirect.com/science/article/pii/S016773222600334X

For nanoliposomes with hemp protein, an analysis of what improves their stability & bioavailability
Impact of sterol stabilizers (cholesterol, beta-sitosterol, gamma-oryzanol) on the physicochemical and antioxidant properties of hempseed protein hydrolysate-loaded nanoliposomes
https://www.sciencedirect.com/science/article/pii/S2772502226003215

🍞 Food & Nutrition 🍞

In Pacific white shrimp (often farmed for food), CBD promoted growth, enriched muscle fatty acids & beneficially restructured the intestinal microbiome
Moderate Dietary Cannabidiol Enhances Growth, Restructures Gut Microbiota, and Bolsters Environmental Stress Resilience in Litopenaeus vannamei
https://www.mdpi.com/2076-3921/15/4/475

For cannabis seeds, an analysis of their nutritional profile
Assessment of nutritional and functional profile of whole, hulled and germinated hemp (Cannabis sativa L.) seeds
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1825902/full

🏗️ Industrial Uses & Fiber 🏗️

For 3D printing, adding hemp straw improved deformation capacity
A comparative life cycle assessment of hemp straw polylactide (PLA) and pure PLA parts printed using fused filament fabrication
https://www.sciencedirect.com/science/article/pii/S2772801326000138

For molded fiber packaging, an analysis of the best combination of hemp hurds, starch & cellulose nanofibrils
Upcycling of industrial hemp byproducts into a sustainable molded fiber packaging system
https://www.sciencedirect.com/science/article/abs/pii/S0141813026018854

For curved pipe, a performance analysis of a hemp-glass/epoxy hybrid
Performance of Hybrid Hemp-Glass/Epoxy Curved Pipe Under Bending
https://www.taylorfrancis.com/chapters/edit/10.1201/9781779644084-30/performance-hybrid-hemp-glass-epoxy-curved-pipe-bending-asad-khalid-shazleen-sabat-asad

Or creating a fabric resistant to fire, water & bacteria, on combining hemp cellulose with chitosan & silicone polyurethane
Phytic acid-chitosan/silicone polyurethane composite coating: A versatile strategy for flame-retardant, water-repellent, and antibacterial hemp cellulose fabrics
https://www.sciencedirect.com/science/article/abs/pii/S0141813026019483

For stabilizing clay, the addition of hemp fiber & eggshell powder improved the soil strength, ductility & durability
Sustainable stabilization of kaolin clay by waste eggshell powder & hemp fibre: Mechanical & microstructural study
https://www.sciencedirect.com/science/article/pii/S2590123026014581

For concrete reinforced with hemp & perlite, an analysis found improved acoustic performance but decreased compressive strength
Experimental Study on Sound Absorption and Insulation Characteristics of Hemp-Perlite Fibre-Reinforced Concrete
https://journals.rcsi.science/2542-0526/article/view/408120

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

🏥 Public Health & Bioassays 🏥

Among US adults using medical or recreational cannabis, public health data on the demographics & mental health
Characterization of medical and recreational cannabis use among U.S. adults: Results from a nationally representative sample
https://www.sciencedirect.com/science/article/abs/pii/S0165178126002179

In sexual minority men, marijuana use was associated with higher levels of intimate partner violence
The Relationship Between Intimate Partner Violence, Anxiety, and Marijuana Use Among Sexual Minority Men
https://journals.sagepub.com/doi/abs/10.1177/08862605261436926

For the Cannabis Health Literacy Questionnaire, an analysis of the demographics of Canadians who answered
The Cannabis Health Literacy Questionnaire – Assessing Reliability and Known-Groups Validity in a Canadian Adult Sample
https://journals.sagepub.com/doi/pdf/10.1177/00472379261439959

For analyzing cannabinoid metabolites in urine, on optimizing a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method
Optimisation and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for cannabis and its metabolites in urine
https://www.sciencedirect.com/science/article/pii/S1570023226001406

For detecting THC metabolites in hair, on the forensic challenges
Challenges in the Interpretation of Isolated THC-COOH Detection in Hair: Forensic and Clinical Implications
https://pubmed.ncbi.nlm.nih.gov/41978365/

🧒 Adolescents & Young Adults 🧒

For adolescents using cannabis, on the different effects depending on their motives
Motives matter: predictive value of cannabis use motives in adolescents with dual disorders – A longitudinal study
https://www.sciencedirect.com/science/article/pii/S0306460326001152

For predictors of cannabis use in youth, this cohort study found an association with impulsivity & parental monitoring as well as cannabis use disorder associated with earlier initiation
Time-Varying Environmental and Polygenic Predictors of Substance Use Initiation in Youth: A Survival and Causal Modeling Study in the ABCD Cohort
https://arxiv.org/pdf/2604.07368

In youth using cannabis, protective behavioral strategies increased with the frequency they were seen in peers
Perceived Descriptive Norms Are Associated With Cannabis Protective Behavioral Strategy Use Directly and Indirectly Through Efficacy in Young Adults: Replication and Extension of Alcohol Findings
https://www.jsad.com/doi/abs/10.15288/jsad.25-00361

In college students, cannabis use frequency was not correlated with their GPA
Cannabis Use and Academic Performance in College Students: Examining the Relationship Between Protective Behavioral Strategies and Grade Point Average
https://www.mdpi.com/2813-1851/5/2/11

In youth with depression & cannabis use disorder, Medicaid data found them to be more likely to have other substance use disorders, to have histories of self-harm & to be less likely to receive psychotherapy
Clinical Complexity of Youths With Major Depression and Cannabis Use Disorder: Evidence From a National Medicaid Cohort
https://psychiatryonline.org/doi/abs/10.1176/appi.ps.20250654

For youth & hemp-derived cannabinoids, a survey in Lexington, Kentucky on their ingestion methods & motivations
Hemp-derived cannabinoid use among young adults in Lexington, Kentucky in 2024
https://assets-eu.researchsquare.com/files/rs-9108504/v1/3ee05c86-9155-42d7-8e75-2849be4cdb2c.pdf

In adolescents with chronic pain, they were more likely to use both alcohol & cannabis
Psychological, behavioral, cognitive and social factors associated with single vs dual alcohol and cannabis use in adolescents with chronic pain
https://www.sciencedirect.com/science/article/abs/pii/S0306460326001140

In adolescents with cannabis use disorder, public health data analyzed their reasons for treatment delays
Admission Delays in Receiving Treatment for Cannabis Use Disorder among US Adolescents
https://www.sciencedirect.com/science/article/abs/pii/S0749379726001042

🧠 The Brain & Neurological Disorders 🧠

In someone with epilepsy, CBD significantly improved their EEG readings
Improvements in EEG tracing following initiation of cannabidiol: a case report
https://scholarlyexchange.childrensmercy.org/cgi/viewcontent.cgi

In an adult with a rare treatment-resistant epilepsy & a learning disability, on adding CBD isolate to their treatment
Adjunctive Cannabidiol for Pharmaco-Resistant Lennox–Gastaut Syndrome in an Adult with Learning Disability
https://napier-repository.worktribe.com/output/4800589

In a mouse model of anxiety, THC increased anxiety levels at high doses via the release of endocannabinoids from the dorsomedial striatum, activating CB1 receptors in the anterior cingulate cortex (emotional & cognitive processing)
CB1 receptor signaling at the cingulate-striatal circuit is anxiogenic
https://www.nature.com/articles/s41467-026-71574-x_reference.pdf

In microglia (guardian immune cells of the brain), cannabis essential oils reduced activation & inflammation
Hemp Waste to Health: Investigating the Anti-inflammatory Potential of Cannabis sativa L. Essential Oils on a Human Microglial Cell Model
https://link.springer.com/article/10.1007/s12649-026-03606-y

In a rat model of genetic absence epilepsy, inhibiting the FAAH enzyme (which breaks down anandamide) caused a robust & sustained reduction in absence seizures via increased levels of anandamide in the thalamocortical network
Circuit-Selective FAAH Inhibition Suppresses Experimental Absence Seizures
https://pubmed.ncbi.nlm.nih.gov/41969140/

For the production of myelin (the protective sheaths of neurons that degrade in multiple sclerosis), the CB1 receptors are “prominent modulators” of the initial steps of the early cellular differentiation & were also essential for the final stages of maturation during myelin regeneration
Cannabinoid CB1 receptors drive oligodendrocyte maturation during myelin regeneration
https://link.springer.com/article/10.1186/s12964-026-02852-w

In a tissue model of brain glucose metabolism, activation of the GPR55 receptors (which may one day be known as CB3) in the astrocytes (the brain’s most common support cell) by the endocannabinoids PEA or LPI stimulated glucose uptake & metabolism
Astrocytic GPR55 receptors promote glycolysis
https://link.springer.com/article/10.1186/s42238-026-00407-x

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

In Black Queer people, anxiety or depression increased their likelihood of co-using alcohol & cannabis
Daily anxiety and depressive symptoms are associated with greater same-day cannabis-alcohol co-use than single-substance use among Black sexual and gender minority people
https://www.sciencedirect.com/science/article/pii/S0955395926001258

For autism, a proposal of increasing cognitive flexibility with cannabinoid-terpene interactions
Supporting Cognitive Flexibility in Autism: Mechanistic Insights into Cannabinoid–Terpene Interactions
https://www.preprints.org/frontend/manuscript/1d033cc0fd35e201b76aa64d249e85b1/download_pub

For autism & cannabis use disorder, this hypothesis using California public health data suggested that legalization increased the rates of autism
Hypothesis: Emerging Evidence Might Suggest That Increases in Cannabis Use Disorder Following Legalization of Recreational Cannabis Significantly Contribute to SocioeconomicDependent Increases in the Prevalence of Autism Spectrum Disorder
https://www.preprints.org/frontend/manuscript/84a2f67481f90b9a64cefd28e458470f/download_pub

For people identified as having cannabis use disorder according to the new DSM-5, public health data on their characteristics
Identification of cannabis use disorder using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM‐5) versus DSM‐5‐proxy measures: Differences by socio‐demographic characteristics
https://onlinelibrary.wiley.com/doi/pdf/10.1111/add.70411

For cannabis use disorder, validation of a Spanish language checklist for diagnosis
Psychometric valida1on of Cannabis Withdrawal Checklist in a Spanish sample with cannabis use disorder
https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2026.1744004/abstract

For someone with cannabis use problems, a case study of using ecological momentary assessment as an add-on to motivational interviewing
Personalized Ecological Momentary Assessment and Networks to Improve Client-Practitioner Communication in Motivational Interviewing for Cannabis Use Problems: A Case Study
https://link.springer.com/article/10.1007/s10608-026-10733-2

🦠 The Immune System & Microbial 🦠

In a mouse model of graft-versus-host disease, deletion of their CB2 receptors protected against neuronal loss & inflammation but not the acute behavioral dysregulation
Role of Cannabinoid Receptor Type 2 in Acute Behavioral Responses to Graft Versus Host Disease in Male Mice
https://journals.sagepub.com/doi/full/10.1177/25785125261442840

🧬 Reproduction & Hormones 🧬

For harm reduction counseling around perinatal cannabis use, on creating an initial list of core components
Identifying an initial set of core components for perinatal cannabis use harm reduction counseling: An application of the Consensus on Relevant Elements (CORE) process
https://www.frontierspartnerships.org/journals/advances-in-drug-and-alcohol-research/articles/10.3389/adar.2026.15935/full

For detecting cannabinoids in meconium (a baby’s first poop), on the detection level of various metabolites
Δ8‐tetrahydrocannabinol, Δ9‐tetrahydrocannabinol, and cannabidiol carboxylic acid metabolites in authentic meconium samples
https://onlinelibrary.wiley.com/doi/abs/10.1111/1556-4029.70335

🦴 Pain, Musculoskeletal, Inflammation & Surgeries 🦴

At a US rheumatology clinic, cannabis use was associated with longer flares of rheumatoid arthritis, but not increased flare frequency
Pilot Cross-Sectional Study Assessing the Correlation between Marijuana Use and Rheumatoid Arthritis and Systemic Lupus Erythematosus Exacerbations
https://www.ovid.com/jnls/smajournalonline/abstract/10.14423/smj.0000000000001956~pilot-cross-sectional-study-assessing-the-correlation
This small study of only 85 people is not very convincing. If you guess, as is often the case, that people with the more intense form of a disease are more likely to turn to cannabis, then of course the people with rheumatoid arthritis using cannabis are the ones with the most intense flares.

In trauma patients, those who were using cannabinoids & cocaine had no significant hospitalization differences from those who were using only cannabinoids
Combined Impact of Cannabinoids and Cocaine on Outcomes of Trauma Patients
https://www.sciencedirect.com/science/article/pii/S2666262026000240

In a mouse model of neuropathy from chemotherapy, this in-depth thesis project found significant reductions from the inhibition of the FAAH enzyme (which breaks down anandamide) & the blocking of the TRPV1 channel as well as their combination
Investigation of chemotherapy-induced peripheral neuropathy-related behaviour in male and female rats: a role for the endocannabinoid system
https://researchrepository.universityofgalway.ie/entities/publication/6f0cecb8-f5f0-4c08-8cfa-dcae084bd225

In a mouse model of muscle wasting due to immobilization, blocking the CB1 receptor with Rimonabant lessened the muscle mass loss, but surprisingly, Rimonabant amplified the decrease in muscle protein synthesis more in younger mice than in older mice
Rimonabant treatment partly attenuates skeletal muscle loss following immobilization in young and in old, sarcopenic male mice
https://repository.uantwerpen.be/docman/irua/ec9809motoM9d

🖐️ The Skin & Topicals 🖐️

For CBD massage creams, an industry-sponsored study found that their own product had the best organoleptic (sensory) properties
Perceptual qualities of Physiorelax® CBD cream compared to three other topical cannabidiol creams for musculoskeletal health care: an organoleptic approach by an expert panel: Application properties of Physiorelax® CBD compared to other CBD-containing creams
https://scientificeditorial.com/index.php/JAC/article/view/Perceptual-qualities-of-Physiorelax-CBD-cream

🎗️ Cancer & Chemotherapy 🎗️

For CBD & leukemia, network analysis found 88 overlapping targets “with enrichment in the neuroactive ligand-receptor pathway, calcium signaling pathway, and membrane function pathways”
Integrative lipidomics and network pharmacology reveal the mechanisms of cannabidiol in the treatment of acute myeloid leukemia
https://journal.stemfellowship.org/doi/pdf/10.17975/sfj-2026-007

In colorectal cancer cells, CBN & THCA caused anticancer effects
Cannabinoids Characterization and the Anti-cancer Activity of Cannabis sativa Stem Extracts against Colorectal Cancer Cell
https://lafiascijournals.org.ng/index.php/ljsir/article/view/808

For gliomas (the most aggressive brain cancer), a dissertation on CBD’s antitumor effects
CBD as therapeutic agent for malignant glioma
https://edoc.ub.uni-muenchen.de/36698/1/Richter_Sven.pdf

For reversing T cell exhaustion in tumors, blocking the CB1 receptor reduced markers of exhaustion
Targeting CB1 and TRPM8 receptors to counteract CD8+ T cell exhaustion
https://www.nature.com/articles/s41598-026-46794-2_reference.pdf

In lung cancer, a review on the antitumor mechanisms used by the cannabinoids
Cannabinoid-Driven Rewiring of GPCR and Ion Channel Signaling in Lung Cancer
https://www.mdpi.com/2227-9059/14/4/856

In oral cancer cells, a review on the ability of CBD to exert antitumor effects via the modulation of the secretion of extracellular vesicles
Inhibition of extracellular vesicle secretion by cannabidiol: A promising approach for oral squamous cell carcinoma therapy
https://www.sciencedirect.com/science/article/pii/S0006295226002819

🔬 Biochemical Discoveries & Research Tools 🔬

On the design of new drugs to activate the CB1 receptor with reduced side effects
Rational design of Gi-biased CB1 agonist with reduced side effects
https://www.cell.com/cell/abstract/S0092-8674(26)00287-4

For inhibiting the FAAH enzyme (which breaks down anandamide), on searching for chimeras to break it down
Rational design, molecular characterization and dissociation mechanisms of PROTACs targeting hFAAH
https://pubs.rsc.org/en/content/articlelanding/2026/cp/d5cp04715c/unauth

When using microalgae to produce cannabinoids, the enzymes for synthesis can be inserted but something keeps them from actually producing cannabinoids
Functional Expression of the Aromatic Prenyltransferase NphB in Chlamydomonas reinhardtii Highlights Challenges in Cannabinoid Biocatalysis
https://www.mdpi.com/2073-4344/16/4/346

On the electronic properties of CBD, THC & CBN, using density functional theory to analyze their reactivity potentials & quantum parameters
Investigation of quantum chemical parameters of hemp (Cannabis sativa) components (CBD, CBN, THC) using density functional theory (DFT)
https://pdf.journalagent.com/pajes/pdfs/PAJES-85833-RESEARCH_ARTICLE-KARTALOGLU.pdf

Thanks.
- lex

PS: For this week’s King of the Clarinet, the 1959 album ‘Pete Fountain’s New Orleans’. Born in the Bayou St. John neighborhood of New Orleans, Pete Fountain’s family came to the city in the French migrations of the 1800s. With weak lungs as a child & frequently sick, a local doctor advised his father to have the youngster take up some instrument that required blowing. With the choice of anything at the local music store, Pete chose a clarinet. It took him a while until he had the lung strength to make any sound, but eventually he improved the health of his lungs by playing along with records of Benny Goodman & by his teen years, he was regularly playing on Bourbon Street. He shared that “when I was a high school senior, my history teacher asked me why I didn’t study more... I answered that I was too busy playing clarinet every night, and when I told him I was making scale — about $125 a week — he said that was more than he made and I should play full time. I guess I was a professional from that point on.”
Fountain played widely in New Orleans across the 1950s but his big break was going to Los Angeles for a string of appearances on the Lawrence Welk show from 1957 to 1959, though he eventually left because “champagne and bourbon don’t mix.” He was then hired by Decca where he went on to produce 42 albums. Fountain returned to New Orleans & founded a freelance marching unit known as the Half-Fast Walking Club (though the original name was The Half-Assed Walking Club, which parade organizers didn’t love). In the 60s & 70s, he owned his own club in the French Quarter where a string of stars would appear like Frank Sinatra, Carol Lawrence & Robert Goulet, Robert Mitchum & Brenda Lee. The club remained open until 2003 & Pete Fountain continued playing until soon before his death 10 years ago from heart problems.

This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.
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PMS pain & CBDA vaginal suppositories + #CancerWeek + CHS & hot water bathing harms

Lex Pelger WhiteWhaleCreations — Mon, 13 Apr 2026 04:01:53 GMT

Cannabinoids & The People,
or; Drugs & Drug Wars

[this newsletter will be on vacation the next 2 weeks due to the ICBC conference & travel back to PA with the kids for the wedding of my 80+ year old uncle (#younglove)]

🌟 #ThisWeek 🌟

(#hashtags for jumping to articles by searching for them with your browser)

For PMS pain, vaginal CBDA suppositories
#CancerWeek: cannabis for cancer pain, nausea & sex + results from the 2026 American Association for Cancer Research Conference
Medical cannabis from workers’ comp: Colorado says thumbs up!
On allergies, 2 strange case reports (#allergies)
For your rescued horse with open wounds, topical & oral THC & CBD
#CHS: 2 case reports of severe problems from the hot water bathing
Preclinical: CBG for arthritis & depression + CBD & BDNF for Alzheimer’s + THC & CBD for Parkinson’s
THC & CBD discovered on an exoplanet!!! (this year’s best #AprilFools)
Taoism & drugs special interest unlocked! (#taoism)
Products: 2 on hemp in body armor (#bullets)

(Numbers for C&P#184: ~6.8k words, ~17 minutes reading time, 127 papers)

📌 Editor’s notes 📌:
Thanks to everyone who filled out the survey from last week. As you can see above, I decided to create a hashtag system to help you quickly find the articles referenced at the top. Let me know if it’s too confusing or hard to read (#WorkInProgress). I’m also going to experiment more with breaking out more sections in the ‘best of cannabinoid science’ when a week happens to get several papers on one topic, like this week with cancer & prenatal cannabis use.

Also, hello to all the new subscribers! I don’t know what happened or where online I got referenced, but there is a flood of new people this week. So besides welcome, I just wanted to reiterate to everyone that my science archives are open to anyone. If there is a specific organ system or disease where you want the data on cannabinoids for sharing to loved ones or healthcare practitioners, I have it all organized in docs. Just reach out & I’ll send it over.

Hello everyone,
Welcome to the 184^th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news as well as the War on Drugs, harm reduction & other psychoactives. Support this work with a paid subscription or by buying me a coffee.

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@CannabinoidsAndThePeople on YouTube, TikTok & LinkedIn
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Cannabis turning on you

Canna-science Videos for CV Sciences on YT @CVSciencesInc & on TT @pluscbd
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@LexPelgerAndHisBooks on TikTok, YouTube & Instagram:

‘The Busy Man’s Prayer’ from Buber’s ‘Tales of the Hasidim’
‘White Malice: The CIA and the Covert Recolonization of Africa’ by Susan Williams

And as always, at the bottom is the album of the week: Jamaican vocal heroes, The Maytals

💖 Ways to support this work 💖

📣 A request to spread the word 📣

This newsletter only spreads by word of mouth, so please share to friends & colleagues.

🍃 BEST OF CANNABINOID SCIENCE 🍃

(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)

The only #AprilFools joke you need: An exoplanet detected with THC & CBD in the atmosphere
First Detection of Exoplanetary Cannabinoids: Evidence for THC and CBD in the Atmosphere of K2-18b
https://arxiv.org/pdf/2603.29700
And oh man, did they put in their work. 15 pages of 420 jokes & Cosmic Humor.
Plus, check out the author list…

⚕️ Clinical ⚕️

In humans with premenstrual pain & in a rat model, a vaginal suppository of both CBD & CBDA relaxed contractions & lowered pain, with CBDA being more potent
CBDA and CBD Diminish Spontaneous Contractions of the Myometrium in vitro and Significantly Ameliorate Pain in Primary Dysmenorrhea
https://academic.oup.com/jsm/article/23/Supplement_3/qdag063.150/8614438

In people with osteoarthritis of the thumb, topical CBD caused greater functional gains than a topical NSAID (diclofenac)
A Randomized Controlled Trial Comparing Topical Cannabidiol to Topical Diclofenac for the Treatment of Osteoarthritis of the Thumb
https://www.ors.org/wp-content/uploads/AM26/571.pdf

For Colorado’s medical cannabis reimbursement in workers’ compensation, participants reported meaningful reductions in pain & improvements in function, quality of life & psychosocial stability as well as a modest reduction in opioid use
Medical Cannabis Reimbursement in Workers’ Compensation: Insights from a Program Evaluation in Colorado
https://journals.lww.com/joem/abstract/9900/medical_cannabis_reimbursement_in_workers_.1107.aspx

In active female CBD users, a survey found lower resting energy expenditure, shorter sleep duration & lower quality of life measurements
Health Characteristics of Recreationally Active Female Cannabidiol Users: A Real-World Cross-Sectional Study
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1823307/abstract

For a rescued horse with an open wound & chronic pain, a case report on the combination of oral & topical THC-rich & CBD-rich full-spectrum oils found sustained improvements in appetite, body condition, pain & mobility as well as marked wound improvement
Case Report: Oral and Topical Chronic Administration of THC-Rich and CBD-Rich Cannabis Oil as Palliative Care in a Rescued Horse with Open Wound, Sarcoid and Chronic Pain
https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1794084/abstract

#CancerWeek

(The interesting human studies are here. The animal & tissue studies are in the ‘Cancer & Chemotherapy’ section at the bottom. And you can search “aacrjournals.org” to see all the results from the 2026 American Association for Cancer Research conference)

For cancer pain & symptoms, the UK Medical Cannabis Registry found cannabis-based medicinal products improved all health outcomes measured
Cannabis-based medicinal products for cancer pain: a two-year prospective analysis from the UK medical cannabis registry
https://www.tandfonline.com/doi/pdf/10.1080/09699260.2026.2650901

For people using cannabis during cancer treatment, a survey found the majority reported cannabis helping with pain, appetite loss, insomnia, irritability, anxiety & nausea, with 20% saying it revived their interest in sexual activities
Cannabis use during cancer treatment: Patterns and perceptions of cannabis use among cancer survivors at a Wisconsin cancer center
https://aacrjournals.org/cancerres/article/86/7_Supplement/1242/776834

In cancer survivors, a meta-analysis of 27 studies found 15% to have used cannabis in the last month, though they had lower odds of use than people who never had cancer
Cannabis use among cancer survivors: a systematic review and meta-analysis
https://link.springer.com/article/10.1186/s13690-026-01911-5

In people with a brain tumor, 600 mg of CBD isolate per day for 3 weeks did not reduce anxiety or depression symptoms
Cannabidiol for anxiety and depressive symptoms in primary brain tumors: results from an early-terminated placebo-controlled crossover randomized clinical trial
https://watermark02.silverchair.com/npag025.pdf

For cancer, a review on the interactions among cannabinoids & flavonoids
Cannabis sativa Phytochemicals in Cancer Therapy: Molecular Mechanisms and Therapeutic Potential
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1768210/abstract

Prenatal cannabis use

For cannabis use during pregnancy, a survey found the most common reason was for insomnia
Sleep Motives and Expectancies for Cannabis Use in Pregnancy
https://publications.sciences.ucf.edu/cannabis/index.php/Cannabis/article/view/372

For prenatal cannabis use, public health data found that it was not associated with increased risk of offspring anxiety or depression
Prenatal Cannabis Use and Child Diagnoses of Depressive and Anxiety Disorders
https://publications.sciences.ucf.edu/cannabis/index.php/Cannabis/article/view/362

For prenatal cannabinoid exposure, a review of the effects on the offspring’s heart & lungs
Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes
https://physoc.onlinelibrary.wiley.com/doi/pdfdirect/10.1113/JP289280

📑 Reviews 📑

For autism, a review of 13 studies suggested “that cannabis, especially cannabidiol, may result in improvements in ASD symptoms such as restlessness, irritability, stereotypic behaviors, social interaction, and emotional regulation”
Efficacy and safety of medicinal cannabis use in autism spectrum disorder: an integrative review
https://residenciapediatrica.com.br/Content/pdf/en_v16n1e1427.pdf

For the effects of CBD & hemp oil on drug test results, a review of 12 studies found that positive test results might occur & that there’s a potential for CBD to convert to THC during manufacturing or in the human body (that last part is hotly debated)
Impact of CBD and hemp oil use on drug test results: a systematic review
https://link.springer.com/article/10.1007/s00414-026-03790-5

In neurodegenerative diseases, a review of the various drugs that target the endocannabinoid system
The role of cannabinoid ligands in neurodegenerative diseases: Emerging anti-inflammatory, immunomodulation and disease-modifying perspectives
https://www.sciencedirect.com/science/article/pii/S1043661826001003

For neurodegenerative diseases, a review on the benefits of CBD
Cannabidiol from Cannabis sativa: A Potential Therapeutic Agent for Neurodegenerative Diseases
https://www.researchgate.net/profile/Sreenivasulu-Sura/publication/403422001_Tropical_Journal_of_Natural_Product_Research_Cannabidiol_from_Cannabis_sativa_A_Potential_Therapeutic_Agent_for_Neurodegenerative_Diseases/links/69cdbff7ac381228756598ef/Tropical-Journal-of-Natural-Product-Research-Cannabidiol-from-Cannabis-sativa-A-Potential-Therapeutic-Agent-for-Neurodegenerative-Diseases.pdf

For muscle preservation in people with muscular dystrophy, this review found limited clinical data but promising potential on the combination of exercise & CBD
Muscular Dystrophy Muscle Preservation: A Comparative Systematic Review of Exercise and Cannabidiol (CBD) Interventions
https://www.researchgate.net/profile/Andre-Aabedi-2/publication/403332713_Muscular_Dystrophy_Muscle_Preservation_A_Comparative_Systematic_Review_of_Exercise_and_Cannabidiol_CBD_Interventions/links/69cbfccb3c61894306728a73/Muscular-Dystrophy-Muscle-Preservation-A-Comparative-Systematic-Review-of-Exercise-and-Cannabidiol-CBD-Interventions.pdf

⚠️ Harms ⚠️

In people with ADHD, both cannabis use disorder & alcohol use disorder were associated with reduced odds of a clinical response to pharmacological treatment
Factors Associated with Reduced Clinical Response in Adult ADHD: The Role of Alcohol and Cannabis Use Disorders and Autism Spectrum Disorder
https://www.mdpi.com/2077-0383/15/7/2688

For peanut allergies, a case report of a 2-year-old whose peanut, mugwort & cannabis allergies might have been sensitized via passive cannabis smoke exposure (#allergies)
The Evolving Contribution of Cannabis Exposure to Peanut Allergy Development: A Case Report
https://assets.cureus.com/uploads/case_report/pdf/461403/20260331-138308-7f5oxg.pdf

For tomato allergies, a case report where cannabis might have been a primary sensitizer for a strong tomato allergy reaction
Dual Anaphylaxis Triggered by Cannabis and Tomato: A Case Report
https://megajournalsofcasereports.com/wp-content/uploads/2026/03/MJCR-93-2419.pdf

For cannabinoid hyperemesis syndrome, a case report of a prolonged hot bath leading to hypothermia & cardiac arrest (#CHS)
The Near‐Fatal Bath: A Case Report With Literature Review of Diagnosis and Management of Cannabinoid Hyperemesis Syndrome
https://www.proquest.com/openview/9f566a4afe68959c8307be5d977fc108/1

For cannabinoid hyperemesis syndrome, a case report of someone found unresponsive in the shower with scalding burns
Cannabinoid Hyperemesis, Burn Injury and Nutritional Support: A Case Report and Clinical Implications
https://academic.oup.com/jbcr/article/47/Supplement_1/S249/8607480

In people with cyclical vomiting syndrome, public health data showed cannabis use associated with increased healthcare utilization & poorer outcomes
Cannabis Use Is Associated With Increased Healthcare Utilization and Poorer Outcomes in Cyclical Vomiting Syndrome—A Propensity Matched Analysis of 34,988 Individuals
https://onlinelibrary.wiley.com/doi/abs/10.1111/nmo.70263

In US adults using synthetic cannabinoids, public health data on their demographics
Disparities in Synthetic Cannabis Use Among U.S. Adults, 2022–2024
https://www.mdpi.com/2813-1851/5/2/9

For kush (synthetic cannabinoid) poisonings in Sierra Leone, on the clinical presentations, including 9 deaths
Clinical presentation and risk factors for severe outcomes in suspected kush poisoning, Sierra Leone, June–November 2025
https://afenet-journal.org/wp-content/uploads/2026/03/Article-33-Vol9.pdf

In people exposed to the synthetic cannabinoid ADB-CHMINACA, a case series of their clinical presentations, with the most common symptoms being panic attacks, tachycardia, agitation, vomiting & seizures
Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome
https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1002/bcp.70538

For detecting synthetic cannabinoids in dead bodies, on the demographics & limits of testing
Detection of Synthetic Cannabinoids in Postmortem Samples: A Retrospective Toxicological Audit at Hyderabad, Pakistan
https://journal.hbs.edu.pk/volume5_issue2/volume_5_issue_2_complete.pdf

In people at the emergency department, public health data found that those with cannabis use disorder had higher rates of mortality within 3 years, but no significant differences in strokes
Cardiovascular Risks Associated With Cannabis Use Among ED Patients
https://assets.cureus.com/uploads/original_article/pdf/459347/20260403-239653-47bfyc.pdf

For cannabis use disorder, a review on the difficulty of studying prevalence & the limited evidence for treatment benefits
Cannabis Use Disorder in the Era of Legalization: Implications for Addiction Treatment Systems
https://www.tandfonline.com/doi/pdf/10.2147/SAR.S581271
And for defining cannabis use disorder, a review of 56 studies on the large variability in definitions
Defining Cannabis Use Disorder in Administrative Health Data: A Systematic Review of Case Definitions and Validation Approaches
https://journals.sagepub.com/doi/abs/10.1177/25785125261437621

In a small study, cannabis smokers had a more proinflammatory & immunosuppressive state than non-smokers
Cannabis smoking increases systemic inflammation and reduces immunity
https://aacrjournals.org/cancerres/article/86/7_Supplement/2844/780413

🐁 Preclinical 🐁

In mice taking CBD, the females had significantly higher exposure while males had a longer time of clearance
Sex differences in the disposition of cannabidiol and its metabolites in mice
https://link.springer.com/article/10.1186/s42238-026-00427-7

In a mouse & tissue model of rheumatoid arthritis, CBG lowered the release of proinflammatory cytokines & improved arthritis scores
Cannabigerol (CBG) Modulates Neutrophil Activity and Ameliorates Rheumatoid Arthritis Pathogenesis
https://www.mdpi.com/1424-8247/19/4/560

In a mouse model of depression & cognitive dysfunction, CBG showed the most benefit compared to CBD & CBDV
Therapeutic potential of phytocannabinoids in depression and cognitive dysfunction: Evidence from preclinical models
https://www.sciencedirect.com/science/article/pii/S0753332226003318

In a mouse model of Parkinson’s disease, THC & CBD reduced anxiety, improved cognition, increased brain serotonin levels & reduced neuronal damage
Effects of Cannabidiol and Tetrahydrocannabinol on Behavioral and Neurochemical Alterations in Experimental Parkinson’s Disease
https://hal.science/hal-05580337/

In a mouse model of Alzheimer’s disease, CBD lowered inflammation & reactivity of the microglia (guardian immune cells of the brain) but did not improve the impaired behaviors
The effects of chronic cannabidiol administration on brain pathology and behavioral deficits found in the tau P301s-line PS19 mouse model of Alzheimer’s disease
https://journals.sagepub.com/doi/10.1177/13872877261421654

In a mouse model of Alzheimer’s disease, a combination of CBD & the brain growth factor BDNF (a key brain growth factor) reduced levels of the amyloid plaques, decreased proinflammatory cytokines, lowered activation of the microglia (guardian immune cells of the brain), promoted neurogenesis (birth of new brain cells) in the hippocampus (a memory center of the brain) & eventually improved cognitive function
Cannabidiol and pBDNF Cotreatment Attenuates Pathological Symptoms and Improves Cognition in 3 month-Old 5XFAD Mice
https://pubs.acs.org/doi/abs/10.1021/acschemneuro.5c01009

In human microglia (guardian immune cells of the brain), CBD inhibited inflammatory signaling
Cannabidiol Inhibits Interferon-γ-induced Inflammatory Signaling in C20 Human Microglia
https://openresearch.okstate.edu/server/api/core/bitstreams/d52159b0-b0e3-4a65-991d-4d9e8ce6682c/content

🆕 Novel Studies 🆕

(a grab bag section for cool & new stuff)

On drug use in Daoist practice, a review of the history (#taoism)
Psychoactive Substances in Daoist Practice: A Cultural and Historical Perspective
https://www.mdpi.com/2077-1444/17/4/438
Two of my special interests aligned! As people who watch my book videos know, I inherited a large library from Uncle Buck (my friend’s dad who became an adopted grandparent to our oldest child, along with his wife Aunty J). Uncle Buck’s library included Daoist classics beyond the ones I already knew like the Tao Te Ching & the first Chinese alchemical text, The Seal of the Unity of the Three. These included the lovely 15^th century teaching novel ‘7 Taoist Masters’ as well as the other 2 works of the Daoist trinity of sacred texts, the Lieh-tzu & the Chuang Tzu (here’s an excerpt on death & misery). This led me to works like the encyclopedic Huainanzi (which I’m still working through with its lessons on the dangers of anticipation & how to be a hero to the world) as well as the 18^th century thinker Liu Yiming.
So with Daoism becoming more & more important to me over these last years, it was a joy to listen to this paper about the history of psychoactives in Daoist practice as I weeded my garden. This author talks about the history of Daoist psychoactive use, the careful guardrails about how they were used & how everything was in service of ethics & cultivation practices. Now I am searching for this elusive author so I can send her a gushing letter of appreciation.
And of interest to all you canna-seekers out there, here’s the most famous Daoist passage on cannabis from the ‘Tujing Yanyi Bencao [Illustrated Classic with Expanded Meaning Materia Medica]’: “Excessive consumption causes visions of ghosts and manic running. Prolonged ingestion leads to communion with divine spirits and bodily lightness.”

In the Adzagbe youth language along the Ghana/Togo border, here’s a study of their idioms including some about our favorite plant
Identity through idioms in Adzagbe, a Ghana-Togo border youth language
https://www.tandfonline.com/doi/abs/10.1080/14725843.2026.2650402
Special thanks to Dr. Cosmas Rai Amenorvi for sharing the PDF & letting me quote from his work:
“me aka = burn charcoal (smoke cigarret or marijuana)
tɔ dzo gbe = set bush on fire (smoke marijuana)
da zo ɖe zo dzi = put fire on fire (smoke marijuana)
zã dɔwɔnu = use tool (smoke marijuana)”
Personally, from now on, I am now only going to call it “putting fire on fire”.

For the plant Cannabaceae family (which includes cannabis & hops), a spirited defense on the other 11 genre & 100+ species in the family
A pharmacological roadmap for the Cannabaceae family: Prioritizing the therapeutic potential of neglected genera beyond Cannabis and Humulus
https://www.sciencedirect.com/science/article/abs/pii/S0367326X26001486

In sharks of the Bahamas, they were found to have cocaine, caffeine, acetaminophen & the NSAID diclofenac
Drugs in paradise: caffeine, cocaine, and painkillers detected in sharks from The Bahamas
https://www.sciencedirect.com/science/article/abs/pii/S0269749126001880

📰 US Headlines & Fav Articles

Despite Trump’s executive order to reschedule cannabis, the DEA says they have no current plans for moving forward
https://www.marijuanamoment.net/marijuana-rescheduling-appeal-process-remains-pending-despite-trumps-executive-order-dea-says-in-new-filing/

With Trump’s focus on immigration, the Department of Justice has stopped investigating a huge number of cases, including a 45% increase of drug case declinations (formal stopping of an investigation)
https://www.propublica.org/article/trump-doj-immigration-bondi-declinations-criminal-investigations

According to declassified FBI memos, agents are allowed to invest & work in hemp companies but not THC-rich cannabis companies
https://www.marijuanamoment.net/fbi-says-agents-can-invest-and-work-in-hemp-companies-but-not-marijuana-industry-newly-declassified-memo-shows/

In Ohio prisons, on the deaths & overdoses from smoking paper (usually synthetic cannabinoids) & how hard it is to stop it
https://www.themarshallproject.org/2026/03/29/ohio-prisons-drugs-k2-overdose-deaths-prison-conditions

On a person with a two-year psychospiritual crisis triggered by AI & cannabis (“1/2 an ounce of cannabis vape-juice a day, or 500mg THC”)
https://www.ecstaticintegration.org/p/wrestling-with-the-angel-of-ai

History Corner: 1868: the first king of rolling papers, Saul David Modiano, opened his first shop in Trieste
https://hightimes.com/culture/saul-david-modiano-rolling-papers/

🌐 International Updates 🌐

In Thailand, as they backed away from adult-use cannabis sales, the public health minister said they plan to convert the ~11k licensed cannabis shops into regulated medical clinics
https://www.khaosodenglish.com/tech/2026/04/01/thailand-to-shift-cannabis-shops-into-medical-clinics/
And an excellent insider's look on the rise & fall of legal cannabis in Thailand by Kitty Chopak
https://parabolacenter.substack.com/p/for-one-week-it-was-basil-an-interview

In Nepal, a province & a region are moving towards legalizing cannabis cultivation
https://english.nepalnews.com/s/business/two-subnational-governments-in-nepal-on-the-path-to-legalizing-cannabis-cultivation/

On the Ukrainian front line, drug use rampant among Russian soldiers
https://www.aljazeera.com/news/2026/3/12/drug-use-on-ukraines-front-lines-rampant-among-russian-troops

In Japan, a record number of cannabis cases last year with ~6,800 people arrested
https://cannabislaw.report/japan-times-japan-sees-record-cannabis-related-police-investigations-in-2025-6832-individuals-in-cannabis-related-cases/

In a Luxembourg hemp vending machine, buds found containing synthetic cannabinoids
https://cannabislaw.report/media-report-synthetic-cannabinoid-found-in-cannabis-buds-sold-legally-in-luxembourg/
Though even the legal buds are a farce. They contain cannabis with THC acid. And all you need to do with that is heat it with a lighter or put it in the oven for 10 minutes & that THC acid converts to good old regular delta-9 THC.

In South Africa, a thesis project on the hemp value chain
Assessing the Challenges and Opportunities in the South African Industrial Hemp Value Chain
https://scholar.sun.ac.za/server/api/core/bitstreams/fdf84022-03d4-4ace-adc4-0e1b201606b1/content

⚖️ Business, Laws & Education ⚖️

In the EU, an EFSA panel refused to rule on the safety of the CO2 extract of hemp made by Charlotte’s Web
Safety of carbon dioxide extract from Cannabis sativa L. as a novel food pursuant to Regulation (EU) 2015/2283
https://efsa.onlinelibrary.wiley.com/doi/pdfdirect/10.2903/j.efsa.2026.10004

On a hemp & cannabis education initiative developed with the Illinois Hemp Coalition
OPUS Open Portal to University Scholarship - Research Days: Relational Teaching in the Age of AI : Promoting Hemp and Cannabis Literacy Through an Interdisciplinary Community Partnership Model
https://opus.govst.edu/research_day/2026/fri/21/

In young adults, on the effects of cannabis edible advertising & warnings
Effects of cannabis edible advertising messages and warnings on product perceptions among US young adults
https://www.sciencedirect.com/science/article/abs/pii/S0376871626001341

🚓 The War on Drugs 🚓

On the impacts of the US strikes against Caribbean narcotrafficking boats, an excellent analysis by Insight on how the cartels shifted their lanes of transportation
https://insightcrime.org/investigations/did-us-military-strikes-impact-caribbean-drug-trafficking/

In Ecuador, troops on anti-narcotic campaigns were joined by American commandos
https://www.cbsnews.com/news/us-commandos-ecuador-joint-mission-alleged-narco-terrorists/

An InSight report on how Mexico’s fentanyl markets are being shaped by organized crime
https://insightcrime.org/investigations/how-organized-crime-shapes-mexicos-fentanyl-markets/

On Mexico’s Forever War on Drugs by a Mexican professor
https://www.theideasletter.org/essay/mexicos-forever-war-on-drugs/

In Morocco, on the “Narco-Architect” (aka “Tunnel Boss”) who designs the complex tunnels for smuggling hashish into the Spanish autonomous city of Ceuta
https://cannabislaw.report/article-the-narco-architect-who-designed-tunnels-to-bring-hashish-from-morocco-into-spain/

In Colombia & Mexico, on punitive drug control leading to a new criminal oligarchy
Criminal governance and oligarchic rule in Colombia and Mexico: the role of punitive drug-control
https://www.tandfonline.com/doi/abs/10.1080/01436597.2026.2641780

In Brazil, on the colonial history of cannabis control
Colonial Legacies of Drug Policing in Brazil: The Cannabis Case in Historical Perspective
https://www.journals.uchicago.edu/doi/abs/10.1086/739588

In Sri Lanka, dozens of child drug couriers were arrested
https://www.sundaytimes.lk/260322/news/dozens-of-child-drug-couriers-arrested-raise-red-flags-635082.html

In a Vietnamese drug trafficking ring, 4 received death penalty sentences
https://e.vnexpress.net/news/news/crime/4-get-death-penalty-in-ho-chi-minh-city-s-drug-trafficking-ring-5049883.html

In South Africa, 4 police officers arrested for trying to sell cannabis they had seized
https://www.cannabiz-africa.com/blog/four-mpumalanga-cops-nailed-for-trying-to-hijack-cannabis-seizure

On the racism of cannabis prohibition, a dissertation on the history & the need for remedies of the injustices
Cannabis Prohibition: Race, Equality, and the Case for Reform An Analysis of Democratic Equality Theory and the Disproportionate Impact of Cannabis Law & Policy on Black and Minority Ethnic Groups
https://bermudajournal.org/wp-content/uploads/2026/03/BJAR_V1_No1_Publish-Ryan-Robinson-Final_1.pdf

🛡️ Harm Reduction News 🛡️

In San Francisco, a rather negative take on their history of harm reduction trials & approval of their recent tightening of policy
https://www.nytimes.com/2026/04/06/opinion/san-francisco-drugs-decriminalization-fentanyl.html

Harm Reduction Research

For treating opioid use disorder, interviews on the best strategies
Strategies to Support Care Transitions for Patients With Opioid Use Disorder: Pathways and Partnerships for Success
https://journals.sagepub.com/doi/full/10.1177/21501319251387820
“Experts ranked specialized addiction treatment programs, primary care clinics affiliated with hospitals, and harm reduction services as the top priorities for partnerships. Suggested strategies to support transitions clustered into 5 categories: (1) structured care transition programs within hospitals; (2) programs to address social and material needs; (3) data and reporting – internally and externally; (4) low-barrier policies shared among partners; and (5) creating community networks.”

🍄 Psychoactives, Psychedelics & Plant Medicines 🍄

On the decrease of cocaine consumption in the US
https://san.com/cc/why-america-is-falling-out-of-love-with-cocaine/

A takedown of Michael Pollan as a plagiarist & fake guru by writer Erica Rex, who claimed he ripped off her psychedelic story
https://erica-rex.medium.com/my-original-published-work-was-plagiarized-by-a-famous-white-male-writer-now-he-owns-the-topic-19d0e9f5391e

For kava, reports to the US National Poison Data System on liver injuries have been increasing & as has co-use with kratom
Increase in Poison Center Reports Linked to Kratom-Containing Kava Products — National Poison Data System, United States, 2000–2025
https://www.cdc.gov/mmwr/volumes/75/wr/mm7512a1.htm

Psychedelics & MDMA

In a survey of people after distressing psychedelic experiences, one-third met the criteria for PTSD
Post-traumatic stress disorder symptoms following psychedelic use: a naturalistic survey study
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/06C8542F2AD3B1FE07714AED587DE372/S0033291726103754a.pdf/post-traumatic-stress-disorder-symptoms-following-psychedelic-use-a-naturalistic-survey-study.pdf

For people coming to the emergency department after psychedelic use, a chart review of their clinical characteristics
Clinical Characteristics of Emergency Visits Related to Recreational Psychedelic Use
https://link.springer.com/article/10.1007/s10597-026-01620-x
“Common psychiatric symptoms included agitation (25.9%) and anxiety (24.6%). Common nonpsychiatric symptoms included nausea/vomiting (9.5%) and diaphoresis (5.2%). 11.2% of cases required psychiatric hospitalization. Factors associated with psychiatric hospitalization included concurrent cannabis use…, history of bipolar disorder…, and history of a primary psychotic disorder.”

For a mega analysis of psychedelics on brain circuits, a combination of 11 datasets across 5 drugs from 5 countries
An international mega-analysis of psychedelic drug effects on brain circuit function
https://www.nature.com/articles/s41591-026-04287-9

On psilocybin for depression, a meta-analysis of 15 trials
A living systematic review, meta-analysis and open-data resource of randomized controlled trials of psilocybin treatment for symptoms of depression
https://www.nature.com/articles/s44220-026-00630-8

For music in psychedelic therapy, a review of the literature & practical considerations
Holding Space Between Notes: Music, Silence, and Cultural Attunement in Psychedelic-Assisted Therapy
https://www.sciencedirect.com/science/article/pii/S2950484826000081

For borderline personality disorder, review on the potential of psychedelics
Psychedelics as a potential treatment for borderline personality disorder: A narrative review
https://www.sciencedirect.com/science/article/pii/S0165178126002131

For substance use disorders, a framework on using psychedelics, herbs & behavioral interventions
Stronger Together: Psychedelic, Herbal, and Behavioral Interventions as a Combined Framework for Addiction Recovery
https://www.researchgate.net/profile/Matthew-Halma/publication/403514285_Stronger_Together_Psychedelic_Herbal_and_Behavioral_Interventions_as_a_Combined_Framework_for_Addiction_Recovery/links/69d1be12e8c973662964c61b/Stronger-Together-Psychedelic-Herbal-and-Behavioral-Interventions-as-a-Combined-Framework-for-Addiction-Recovery.pdf

For substance use disorders, a review on the use of ibogaine
The Efficacy and Safety of Ibogaine Treatment for Substance Use Disorders - A Narrative Review
https://apcz.umk.pl/QS/article/view/69942

On psychedelics for comorbid depression & chronic pain, a review of the mechanisms of action
Psychedelic Therapies for Comorbid Major Depressive Disorder and Chronic Pain: A Review of Putative Mechanisms of Action
https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.70238

On synthesizing the top 5 natural psychedelics in a tobacco plant
Complete biosynthesis of psychedelic tryptamines from three kingdoms in plants
https://www.science.org/doi/pdf/10.1126/sciadv.aeb3034

Ketamine

For chronic pain, a review of 5 studies found ketamine caused significant short-term pain relief, especially for neuropathic conditions
Subanesthetic Ketamine for Chronic Non-Cancer Pain: A Systematic Review of Evidence from Randomized Trials over the Past Two Decades
https://www.mdpi.com/2813-1851/5/2/10

For adolescent suicidal ideation, a single dose of IV ketamine did not alter their suicidal ideation
Single dose IV ketamine for adolescent suicidal ideation in the emergency department: a pilot randomized trial
https://link.springer.com/article/10.1186/s12888-026-08042-9

Kratom

On using kratom for pain, a review of the limited clinical data
Kratom (Mitragyna speciosa) for pain management: a systematic review of preclinical evidence and limited clinical data
https://www.sciencedirect.com/science/article/pii/S2667031326000291

Cathinones

In Ethiopia, on the regulation of khat
The regulation and control of khat use and access in Ethiopia
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/03B2B88B283D73BA64EFAB8C0CEAA59B/S2054425126101897a.pdf/the-regulation-and-control-of-khat-use-and-access-in-ethiopia-policy-brief.pdf

🍃 The Plant & its Products 🍃

A great history of hemp processing in Italy with a special focus on thermal hot springs for accelerating the hemp retting process
An Unusual Use of Thermal-Mineral Water in the Euganean Area for Hemp Processing during the Time of the Serenissima
https://www.engramma.it/eOS/index.php?id_articolo=6173

🌱 Growing 🌱

For light spectra, on the ranges that most strongly enhanced photosynthetic activity & cannabinoid yield
Interval-Based LED Lighting Enhances Phytochemical Production in Cannabis under Greenhouse Conditions
https://www.ijagbio.com/pdf-files/25-776.pdf

In field-grown hemp, on the effects of density on biomass & yield
Effect of plant population on crop growth, floral biomass, and cannabinoid yield in field‐grown hemp
https://acsess.onlinelibrary.wiley.com/doi/pdf/10.1002/agg2.70348

For hemp seeds, treatment with Trichoderma fungi promoted growth
Seed Treatment with Selected Trichoderma Isolates Enhances Plantlet Growth and Proline Accumulation in Industrial Hemp (Cannabis sativa L.)
https://www.mdpi.com/2673-7140/6/2/17

On enhancing hemp fiber & cannabinoid content via helpful root fungi
Enhancement of fiber content and cannabinoids of hemp using arbuscular mycorrhizal fungi and endophytic fungi
https://www.nature.com/articles/s41598-026-46869-0_reference.pdf

For efficient sex identification of cannabis, on using a high-resolution melting assay
Multiplex high resolution melting using MADC2 and SCAR markers for sex identification of Cannabis sativa L. cultivation
https://www.nature.com/articles/s41598-026-46461-6_reference.pdf

For cannabis cultivars & metabolite correlations, on the related shifts in terpene profiles caused by domestication
Domestication-Driven Metabolite Correlations in Cannabis sativa: A Chemometric Data Fusion Approach
https://www.sciencedirect.com/science/article/pii/S266703132600028X

For trichome differentiation & cannabinoid synthesis, a genetic analysis of their regulatory mechanisms
A Novel CsYABBY3‐CsAS1 Feedback Loop Coordinates Trichome Differentiation and Cannabinoid Biosynthesis in Cannabis sativa L.
https://advanced.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.75055

⚙️ Extracting, Analyzing & Formulating ⚙️

On creating profiles of cannabis chemovars that incorporate the minor cannabinoids
Hierarchical Chemotaxonomic Differentiation in Cannabis Chemovars Using Quantitative HPLC Cannabinoid Profiling and Multivariate Chemometrics
https://www.mdpi.com/2223-7747/15/7/1077

For analyzing low-THC cannabis products, on the most helpful analytical techniques
An Integrated Analytical Approach for the Evaluation of Low-THC Cannabis sativa Products
https://www.mdpi.com/2227-9717/14/7/1172

On increasing CBD bioavailability with nano lipid formulations
Solid Pro-Nano Lipid Oral Formulations for Cannabidiol (CBD)
https://www.mdpi.com/1999-4923/18/4/436

🍞 Food & Nutrition 🍞

In wheat-chia bread, adding hemp flour significantly increased protein, dietary fiber & polyunsaturated fatty acid content
Enrichment of Wheat–Chia Bread with Hemp, and Buckwheat Flours and Cistus incanus L. Infusion: Impact on Chemical Composition, Polyphenols, Fatty Acids, Amino Acids, and Consumer Acceptance
https://www.mdpi.com/1420-3049/31/7/1198

In probiotic goat milk yogurt, adding hemp seed protein concentrate increased the viability of the bacteria during storage & gut transit
Probiotic goat milk yogurt with plant-based prebiotics: Probiotic survival during in vitro simulated gastrointestinal transit
https://www.sciencedirect.com/science/article/pii/S0022030226003152

For films for covering blackberries, on creating one with CBG to reduce mold growth, water loss & color degradation
Development and Characterization of Active Pectin–Curdlan Biopolymer Films with Cannabigerol (CBG) Oil as Innovative Materials with Plant Metabolism–Stimulating Properties and Potential to Extend the Postharvest Shelf Life of Blackberries (Black Satin) Fruits
https://www.mdpi.com/2073-4360/18/7/890

On green extraction methods of hemp seed protein
Green transformation of hemp seed protein: structural modification and functional enhancement with hydrogen-rich water
https://www.sciencedirect.com/science/article/abs/pii/S014181302601723X

In laying hens, dietary hemp seeds decreased intramuscular fat & improved fatty acid composition
Effects of dietary hemp seeds (Cannabis sativa L.) on breast and thigh meat quality attributes, fatty acid profiles, and health lipid indices in laying hens
https://www.vetmedmosul.com/article_190486_2f6e1ef9edd353605cea3b32f7b73a63.pdf

🏗️ Industrial Uses & Fiber 🏗️

For stopping bullets, on the best mix of Kevlar, hemp & carbon nanotubes (#bullets)
Response surface modelling of tensile and impact characteristics of Kevlar/Hemp/CNT reinforced polymer matrix composites
https://link.springer.com/article/10.1186/s40712-026-00435-8

For stopping bullets, on adding a flax/hemp composite to a metal mesh
Ballistic and drop-weight impact response of SS304 metal mesh embedded woven flax/hemp fiber hybrid composites
https://www.nature.com/articles/s41598-026-44055-w

For saliva detection of the immune tumor necrosis factor-α (TNF-α), on creating an immunosensor with gold nanoparticles, polyvinyl alcohol & hemp-derived nanocellulose
Non-invasive detection of salivary TNF-α enabled by hemp-derived nanocellulose nanocomposite electrochemical immunosensor for point-of-care diagnostics
https://www.sciencedirect.com/science/article/abs/pii/S1567539426000824

For hemp textile coatings, on nanotreatment to improve flame resistance, UV protection, antibacterial activity & water resistance
Synergistic strategy of Nano-ZnO/DOPO/fluorinated silicone in waterborne polyurethane coating for multifunctional finishing of hemp fabric
https://www.sciencedirect.com/science/article/abs/pii/S0300944026002213

On creating fire-resistant panels with hemp insulation
ESTABLISHING PATTERNS IN THE FORMATION OF A FIRE-RESISTANT SIP PANEL WITH HEMP INSULATION
https://repositsc.nuczu.edu.ua/bitstream/123456789/28056/1/Tsapko.pdf

For pellets, on 3D printing composites of hemp, polyethylene glycol & polylactic acid
Rheological, Mechanical, and Life Cycle Assessment of 3D‐Printed PLA/Hemp/PEG Biocomposites
https://4spepublications.onlinelibrary.wiley.com/doi/abs/10.1002/pen.70490

For concrete reinforcement, on 3D printing a hemp-polylactic acid composite
Performance Evaluation of Novel 3D Printed Hemp-PLA Composites for Sustainable Concrete Reinforcement
https://www.sciencedirect.com/science/article/abs/pii/S2352710226008235

For bio-concrete, on combining gypsum & hemp shives
Thermal Recycling of Gypsum–Hemp Bio-Concrete: Experimental Evaluation of Dehydration Conditions and Properties Evolution
https://www.mdpi.com/2313-4321/11/4/71

For hemp-lime composites, on optimizing the addition of hemp fibers
Impact of Hemp Fiber Content and Length on the Hygrothermal, Mechanical, and CO2 Emission Performance of Hemp-Lime Composites
https://www.sciencedirect.com/science/article/pii/S2352710226008776

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

A book chapter on the history of cannabinoids in medicine
Phytocannabinoids: Chemistry and Medicine
https://link.springer.com/rwe/10.1007/978-3-642-36202-6_147-1

An Indian review on cannabis therapy & regulation
Medical Marijuana: A Comprehensive Review on Therapeutic Use, Legal Bindings and Regulatory Perspectives
https://ijprt.org/index.php/pub/article/view/1680

For the endocannabinoid system, a review of targeting it for a range of disorders
Assessment on Coordinated Roles of Endocannabinoid System to Combat against Multidimensional Disorders in Human Body
https://hal.science/hal-05580325/

A Moroccan review on the history of cannabis & its modern industrial uses
The Multiple Uses of the Cannabis Plant and its Historical and Modern Development: An Analysis of Challenges and Opportunities
https://www.researchgate.net/profile/Iliass-Bouhlal/publication/403525250_The_multiple_uses_of_the_cannabis_plant_and_its_historical_and_modern_development_An_Analysis_of_Challenges_and_Opportunities/links/69d2deb43c6189430673f3da/The-multiple-uses-of-the-cannabis-plant-and-its-historical-and-modern-development-An-Analysis-of-Challenges-and-Opportunities.pdf

(I have a soft spot for crackpots with an axe to grind) A hypothesis on the fungus Candida co-evolving with humans to enable language via the oscillation of salt levels in African lakes
The Saline Oscillation Hypothesis: Endocannabinoid-Mediated Fungal Hominid Coevolution in the East African Rift Valley
https://www.researchgate.net/profile/Jim-Craddock/publication/403422153_The_Saline_Oscillation_Hypothesis_Endocannabinoid-Mediated_Fungal-_Hominid_Coevolution_in_the_East_African_Rift_Valley/links/69cdb6ede8c97366296350cb/The-Saline-Oscillation-Hypothesis-Endocannabinoid-Mediated-Fungal-Hominid-Coevolution-in-the-East-African-Rift-Valley.pdf
I don’t think the author is subscribed to this newsletter, which is good because I don’t want to hear more about this, but I am glad to know that this theory exists.

🏥 Public Health & Bioassays 🏥

For drug harms in Canada, a panel of experts rated the worst to be alcohol, followed by tobacco, opioids, cocaine, methamphetamine & cannabis at the bottom
Drug harms in Canada: A multi-criteria decision analysis
https://journals.sagepub.com/doi/10.1177/02698811251409147#table1-02698811251409147

For medical cannabis products with higher THC concentrations, this review found mixed outcomes & adverse events including psychiatric, nervous & gastrointestinal effects
Higher THC Concentration Medicinal Cannabis Products Efficacy and Safety Considerations: A Rapid Review
https://onlinelibrary.wiley.com/doi/pdf/10.1111/dar.70145

In Canadians engaging in higher risk cannabis behaviors, they tended to be younger, male, more poor & less educated
Higher risk cannabis use indicators among people living in Canada: a cross-sectional study examining the association with socio-demographic and socio-economic factors
https://link.springer.com/article/10.1186/s13011-026-00722-9

For healthcare providers treating Parkinson’s disease in France, a survey found they were more accepting of using CBD then cannabis
Healthcare providers’ acceptability of cannabis and cannabidiol to manage Parkinson’s disease in France
https://www.sciencedirect.com/science/article/pii/S0011393X26000111

In Polish family physicians, a survey found only limited willingness to prescribe medical cannabis
Readiness to Use Medicinal Marijuana in the Practices of Polish Family Physicians
https://www.mdpi.com/2077-0383/15/7/2670

🧒 Adolescents & Young Adults 🧒

For early cannabis use & the risk of opioid use disorder, public health data found that cannabis use prior to the age of 15 was robustly associated with later opioid use disorder
Early onset of cannabis use and risk for opioid use disorder across two decades in the United States
https://www.sciencedirect.com/science/article/pii/S0306460326001139

In Black & Latino youth, on the factors associated with later alcohol & cannabis use
Latent classes of substance use precursors predict positive alcohol and cannabis expectancies one year later in Black and Latino early adolescents in the ABCD study
https://www.sciencedirect.com/science/article/pii/S0306460326001127

For cannabis use by college students, a review of 44 studies on outcomes
Systematic Review of College Students’ Perceptions of Cannabis: Trends, Risks, and University Implications
https://gexinonline.com/uploads/articles/article-jcssr-115.pdf

🧠 The Brain & Neurological Disorders 🧠

In a female adolescent rat model of neuropathic pain, a sciatic nerve injury caused an increased preference for both CBD & oxycodone, with each causing different changes in the cerebellum
Place preference in a female adolescent rat model of neuropathic pain: The effects of cannabidiol and oxycodone on cerebellum cell density
https://link.springer.com/article/10.1007/s00213-026-07056-1

Someone got very excited about their new system for brain network analysis & cannabis use (#JargonWarning)
Large-scale nonlinear Granger causality enables robust cannabis-use classification through evidence-guided brain-network analysis
https://www.spiedigitallibrary.org/conference-proceedings-of-spie/13929/139290L/Largescale-nonlinear-Granger-causality-enables-robust-cannabisuse-classification-through-evidenceguided/10.1117/12.3086330.short
Large-scale Granger causality analysis of cannabis-related network changes in the resting state with informed priors
https://www.spiedigitallibrary.org/conference-proceedings-of-spie/13929/139290N/Largescale-Granger-causality-analysis-of-cannabisrelated-network-changes-in-the/10.1117/12.3086350.short
Large-scale extended Granger causality with knowledge-informed feature selection for cannabis-use classification
https://www.spiedigitallibrary.org/conference-proceedings-of-spie/13929/139291V/Largescale-extended-Granger-causality-with-knowledgeinformed-feature-selection-for-cannabisuse/10.1117/12.3084099.short
Knowledge-driven large-scale augmented Granger causality for classifying cannabis dependence
https://www.spiedigitallibrary.org/conference-proceedings-of-spie/13929/139290M/Knowledgedriven-largescale-augmented-Granger-causality-for-classifying-cannabis-dependence/10.1117/12.3086329.short

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

In people smoking very low-nicotine content cigarettes, this did not alter their frequency of alcohol or cannabis use
The impact of very low nicotine cigarettes on cannabis and alcohol use during a 12-week clinical trial
https://academic.oup.com/ntr/advance-article-abstract/doi/10.1093/ntr/ntag070/8586492

In a mouse model of one-shot learning (forming a memory after a single brief event), the endocannabinoids mediated this learning in the striatum (decision making & reward)
Striatal endocannabinoids drive one-shot learning
https://hal.science/hal-05574724v1/file/Piette-et-al-Nature-Neurosci-revised2-17032026.pdf

In a rat model of anxiety & depression, there were gendered differences in the effects of the CB2 drug HU-910 & the endocannabinoid-like lipid Oleoyl Serine (OS)
Differential Effects of Oleoyl Serine and HU-910 on Anxiety-like and Depression-like Behaviors in Male and Female WKY Rats
https://www.mdpi.com/1422-0067/27/7/3177

🦠 The Immune System & Microbial 🦠

In hemp hurds, an analysis of the lignins & their antimicrobial effects
Characterization and Antimicrobial Activity of Lignin-Derived Compounds in Ground Hurd Tissue of Cannabis sativa L. (Hemp) Cultivars
https://journals.sagepub.com/doi/pdf/10.1177/1934578X261436515

🦴 Pain, Musculoskeletal, Inflammation & Surgeries 🦴

After knee surgery, 5 mg per day of dronabinol (pharmaceutical THC) did not alter opioid use, self-reported pain levels, sleep or nausea
A Synthetic Form of Cannabinoid Does Not Decrease Opioid Use After Total Knee Arthroplasty: A Prospective, Randomized, Triple-Blind, Placebo-Controlled Study
https://www.sciencedirect.com/science/article/abs/pii/S0883540326001944

In people who had surgery for spinal deformities, the cannabis users had no differences in complication rates
Impact of Preoperative Marijuana Use on Functional Recovery and Complications After Spinopelvic Fusion in Adult Spinal Deformity
https://journals.lww.com/neurosurgpraconline/fulltext/2026/06000/impact_of_preoperative_marijuana_use_on_functional.8.aspx

In a rat model of osteoarthritis, the combination of PEA & cucumber extract worked synergistically to improve pain thresholds & limb function
Synergistic modulation of nociceptive and inflammatory pain by palmitoylethanolamide and Cucumis sativus extract in a monosodium-iodoacetate induced osteoarthritic rat model
https://link.springer.com/article/10.1007/s10787-026-02197-3

For inflammation, on aryl-cyclohexanone as a potential activator of the CB2 receptor
Aryl-Cyclohexanone as a Potential CB2 Agonist: In Vitro and In Silico Evidence in Inflammatory Modulation
https://www.tandfonline.com/doi/abs/10.1080/08923973.2026.2655385

🍽️ The Guts, Nutrition & the Microbiome 🍽️

For reflux disease (acid into the throat), a combination of PEA, sodium alginate, sodium bicarbonate, Barbary fig, olives, bananas & ginger caused “notable reductions in regurgitation and heartburn”
Evaluation of the Efficacy and Safety of a Nutraceutical Containing Sodium Alginate, Sodium Bicarbonate, PEa, a Blend of Opuntia Ficus Indica, and Olea Europaea, Musa Paradisiaca, and Ginger in Patients with NERD
https://www.jnutraceutical.com/articles/evaluation-of-the-efficacy-and-safety-of-a-nutraceutical-containing-sodium-alginate-sodium-bicarbonate-pea-a-blend-of-i-opuntia-ficus-indica-i-and-i-olea-europaea-i-i-musa-paradisiaca-i-and-ginger-in-patients-with-nerd.pdf

In a mouse model of obesity, CB1 does not seem to be the primary driver of obesity associated with a deficit of the autophagy receptor P62 (cellular recycling)
Exploring cannabinoid receptor CB1 autophagy and the obesity phenotype of p62-deficient mice
https://www.sciencedirect.com/science/article/pii/S2405580826001317

🎗️ Cancer & Chemotherapy 🎗️

In Queer people with cancer, they had higher levels of cannabis, tobacco & alcohol use
Tobacco, nicotine, cannabis, and alcohol use among LGBTQ+ patients with cancer: Real-world analysis at an NCI-Designated Comprehensive Cancer Center
https://aacrjournals.org/cancerres/article/86/7_Supplement/7852/778119

In a mouse model of breast cancer, a THC-rich cannabis extract accelerated growth
MRI-Based Radiomics Reveals Cannabinoid-Associated Tumor Phenotypes in a Murine Breast Cancer Model
https://www.mdpi.com/1420-3049/31/7/1154

In a mouse model of liver cancer, CBD inhibited tumor growth & maintained body weight
Enhanced antitumor efficacy and safety of cannabidiol-loaded O-carboxymethyl chitosan nanomicelles in hepatocellular carcinoma
https://www.researchsquare.com/article/rs-9212714/v1

In prostate cancer cells, a hemp extract caused anticancer effects
Dose-dependent anti-proliferative activity of a bioactive hemp-derived extract REPYR-SC1 against prostate cancer
https://aacrjournals.org/cancerres/article/86/7_Supplement/3655/779656

In prostate cancer cells, the antitumor effects of activating CB2 were potentiated by vitamin D
Vitamin D (calcitriol) potentiates CB2-mediated anti-tumor responses in prostate cancer cell lines: Molecular mechanisms and therapeutic potential
https://aacrjournals.org/cancerres/article/86/7_Supplement/3522/781001

In lung cancer cells, CBD enhanced the efficacy of the treatment drug etoposide
Cannabidiol enhances etoposide efficacy in non-small cell lung cancer by engaging a p53-mTOR-TFEB lysosomal death program
https://aacrjournals.org/cancerres/article/86/7_Supplement/4474/777680

In melanoma cells, CBG regulated inflammation & oxidative stress but did not explicitly promote apoptosis (programmed cellular suicide)
Metabolic responses of three distinct melanoma cell lines to UVA radiation and cannabigerol
https://www.sciencedirect.com/science/article/abs/pii/S0891584926002893

In a mouse model of prostate cancer, activating both the CB2 & CXCR4 receptors lowered cancer growth & metastasis
Combined treatment with agonists for CXCR4 and CB2 receptors reduces prostate cancer growth and metastasis
https://aacrjournals.org/cancerres/article/86/7_Supplement/2230/777600

In mice & tissue models of colon cancer, the terpene beta-caryophyllene reduced tumor size & induced apoptosis (programmed cellular suicide)
β-Caryophyllene induces apoptosis and inhibits angiogenesisin colon cancer models
https://aacrjournals.org/cancerres/article/86/7_Supplement/7084/782075

Thanks.
- lex

PS: For the pioneering vocals of Jamaica, the 1970 album ‘Monkey Man’ by the Maytals. Made up of frontman Frederick “Toots” Hibbert along with Henry “Raleigh” Gordon & Nathaniel “Jerry” Mathias, the 3 young vocalists recorded their first song “Hallelujah” in 1962 & in those heady early days of ska, it was a sensation. Within a few years, they recorded a string of classic hits, many being religious songs that appealed to the deeply religious people of the island (I especially like ‘Study War (No More)’). But their first producer started screwing them over, secretly licensing their hits to another label under pseudonyms & giving almost no money to the performers. They left & started recording with some of the best producers on the island as well as a backing group for Desmond Dekker (who was covered previously in C&P#136). By 1966, they recorded a flood of hits & won the island’s first Festival Song Competition with “Bam Bam”. But then Toots got caught with cannabis & received an 18-month jail term. His partners wouldn’t record without him & went on hiatus. Their first song upon his release was the triumphant “54-46 Was My Number”, based on his actual prison number. Then in their 1968 single ‘Do The Reggay’, they coined the term “reggae” & are now listed there in the Oxford English Dictionary. They added instrumentalists to the group & renamed themselves Toots & the Maytals, with the ‘Monkey Man’ album above becoming their first international hit record. With fiery live shows, they spent the ‘70s creating classic albums, touring with the likes of the Who, Jackson Browne, the Eagles & Linda Ronstadt, building up a listener base around the world, especially in the UK. The original group released their last album in 1981, though Toots did later relaunch the Maytals with new members. The group still holds the current Jamaican record for #1 hits: 31.

4th Birthday! + Survey! + Glow-up! + cannabis for exercise, dizziness & early human history

Lex Pelger WhiteWhaleCreations — Mon, 06 Apr 2026 06:21:41 GMT

Cannabinoids & The People,
or; Drugs & Drug Wars

🌟 This week 🌟

CBD for exercise-induced muscle injury
Cannabis helping with dizziness
Topical CBD gel for genetic neurodevelopmental disorder
Cannabis intoxication not helpful for identifying someone in a police lineup
Cardiotoxicity: see the ‘Heart’ section for reports from this year’s American College of Cardiology conference (alert: lousy puns ahead)
Preclinical: prenatal CBD exposure linked to more hyperactivity as adolescents
Evidence of cannabis use in China 4500 years ago
Psychedelics: intranasal 5-MeO-DMT for depression + mescaline for mental health
Winner for the best mobile harm reduction program name: Spike on a Bike

(this week’s numbers: ~6.8k words, ~18 minutes reading time, 122 papers)

📌 Editor’s notes 📌:
It’s the 4^th anniversary of ‘Cannabinoids & the People’ on Substack. Now, the traditional gift for the 4^th anniversary is fruit & flowers, but the modern gift is electrical appliances. So what I want more than anything in the world is an electric vegetable slicer.
In celebration, I did a re-formatting of this newsletter to make it more accessible for you & after a meeting with the social media maven Rachel Colic (highly recommended), I’m going to focus more this year on building up my YouTube channel with longer, horizontal videos filmed against the backdrop of my office. The deeper dives suit my style & I’m looking forward to experimenting more on covering topics close to my heart, such as this one on making all drugs illegal.

Survey:
(you can just reply to this email if you’re reading from Substack, or DM me on LinkedIn. And partial answers are more helpful than no answers. I’m just trying to make this newsletter as useful as possible)
For my questions, the main one is: What’s helpful about this newsletter to you & how do you use it?
- Does anything bug you about it? Especially user interface. I’m trying to make it as easy to quickly parse as I possibly can, while still being my completionist self.
- Are there any areas of coverage related to these that you’d like to hear more on?
- Would hashtags help in the “This Week” section at the top so you can quickly find the article referenced below?

Thanks.
I appreciate all of you following along with this unwieldy whale of a newsletter. I feel lucky that I get to put it together, set it adrift each week & let it land where it might. Around 2,000 of you open it each week & at least run your eye down it. There might even be some obsessive soul out there who goes through each issue cover to cover. And I wanted to say to all of you, thanks for reading it & making it worth it.

Hello everyone,
Welcome to the 183^rd edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news as well as the War on Drugs, harm reduction & other psychoactives. Support this work with a paid subscription or by buying me a coffee.

🤝 Sponsor 🤝: The Cannabis & Health Research Initiative

Want to help expand the knowledge of medical cannabis use in the real world & get paid 100 bucks to do so?

Follow along on Instagram to keep on learning or sign up for the monthly CHRI email (curated by me) to get just the best of clinical research & new reviews twice a month.

🎥 Lex’s new work 🎤

@CannabinoidsAndThePeople on YouTube, TikTok & LinkedIn
Canna-edu videos sponsored the National Cannabis Study (join & get paid $100 to talk about your use of our favorite plant)

All drugs illegal? On the deep racism of the US War on Drugs (my audio could be better, but this one is close to my heart)
That notorious review on cannabis & mental health (hattip to Dr. Uwe Blesching of CannaKeys)
Cannabis turning on you

Canna-science Videos for CV Sciences on YT @CVSciencesInc & on TT @pluscbd
For 30% off their CBD, THC & PEA products, at pluscbdoil.com use the coupon code ‘LEX’

@LexPelgerAndHisBooks on TikTok, YouTube & Instagram:

And as always, at the bottom is the album of the week: a life of Delta blues

💖 Ways to support this work 💖

Ecodelia and the lost art of lichenthropy

- Venmo: @Lex-Pelger

- PayPal: donate here

📣 A request to spread the word 📣

This newsletter only spreads by word of mouth, so please share to friends & colleagues.

🍃 BEST OF CANNABINOID SCIENCE 🍃

(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)

⚕️ Clinical ⚕️

In people with exercise-induced muscle injury, CBD caused less peak pain at rest & with movement as well as less strength impairment & physical disability
Efficacy and safety of cannabidiol (CBD) on reducing pain and functional impairment associated with exercise-induced muscle injury: a randomized placebo-controlled feasibility trial
https://link.springer.com/article/10.1186/s42238-026-00431-x
But for muscle recovery after damage from exercise, a CBD topical did not accelerate recovery or lower soreness
Topical application of cannabidiol for muscle recovery after exercise-induced muscle damage: a randomized, double-blinded pilot study
https://link.springer.com/article/10.1186/s42238-026-00420-0

In people with kidney failure, interviews on the improvements from CBD
WCN26-3667 PATIENT EXPERIENCES WITH CANNABIDIOL FOR SYMPTOM MANAGEMENT IN KIDNEY FAILURE: QUALITATIVE INSIGHTS FROM THE SEISMIC-CBD TRIAL
https://www.kireports.org/article/S2468-0249(26)00342-6/pdf
And on the pharmacokinetics of CBD moving through their system
WCN26-5407 PHARMACOKINETICS OF CANNABIDIOL IN PEOPLE WITH KIDNEY FAILURE: FINDINGS FROM THE SEISMIC-CBD TRIAL
https://www.kireports.org/article/S2468-0249(26)00352-9/fulltext

In people experiencing dizziness, a survey found the majority willing to consider cannabis & 20% reported cannabis to cause a moderate to large subjective relief
A Cross-Sectional Survey of Cannabis Use and Utility Among Patients Experiencing Dizziness
https://www.mdpi.com/2076-3425/16/4/360

In children with 22q11.2 deletion syndrome (a genetic disease of developmental delays & a range of potential effects), a topical CBD gel caused improvements on all measures, including disease severity, anxiety, behavior & caregiver reported effects
Phase 2, open-label INSPIRE trial to assess the tolerability and effectiveness of transdermal cannabidiol gel in children and adolescents with 22q11.2 deletion syndrome (ZYN2-CL-031)
https://link.springer.com/article/10.1186/s11689-026-09687-z

In people with chronic neuropathic pain, capsules of 1:1 THC:CBD caused substantial pain reductions & improved health-related quality of life in physical & social functioning, energy/fatigue & emotional well-being
Analgesic and Quality of Life Effects of 1:1 Delta-9-Tetrahydrocannabinol: Cannabidiol Oral Formulation on Chronic Neuropathic Pain Subjects During a Four-Week Observation Period: Pilot Study
https://www.jpain.org/article/S1526-5900(25)01097-1/abstract

In people with anorexia nervosa, CBD was well tolerated & caused small increases in body mass index
Cannabidiol in Anorexia Nervosa: A Double-Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change
https://pubmed.ncbi.nlm.nih.gov/41906184/

In a case report of someone with geographic tongue (inflammatory patches of missing papillae on the tongue), full-spectrum CBD oil caused significant improvements to oral pain
Full Spectrum Cannabidiol Oil as a Symptomatic Management Strategy in Geographic Tongue: Case Report with Literature Review
https://www.bjcasereports.com.br.editorapcaa.com.br/index.php/bjcr/article/view/bjcr179

When giving CBD to fed or fasting dogs, an analysis of their fecal excretions found better bioavailability when fed
Comparative plasma exposure and fecal excretion of oral cannabidiol in fasted and fed dogs: pilot study
https://link.springer.com/article/10.1007/s11259-026-11170-y

📑 Reviews 📑

On CBD for developmental epilepsy, a review of the mechanisms (with nice charts)
Cannabidiol in Developmental Epilepsy: Organoid-Guided Precision Medicine Across Critical Neurodevelopmental Windows
https://www.mdpi.com/1422-0067/27/6/2899

⚠️ Harms ⚠️

For neurocognitive recovery after cannabis use disorder, a review of 26 studies found cognitive improvements within the first week of cessation & CB1 receptor normalization within a month
Cannabis cessation and neurocognitive recovery: Patterns, predictors, and clinical implications-a systematic review
https://pubmed.ncbi.nlm.nih.gov/41872072/

In people with cannabis-induced first episode psychosis, hopelessness & depression independently predicted psychotic severity
The role of hopelessness and depression in cannabis-induced first-episode psychosis: a 24-month prospective study
https://www.sciencedirect.com/science/article/abs/pii/S0306460326001097

In people with cannabis use disorder, case reports where stellate ganglion blocks (anesthetic injection into nerves of the neck) caused reduced withdrawal symptoms
Stellate Ganglion Block for the Management of Cannabis Use Disorder: A Case Series
https://assets.cureus.com/uploads/case_report/pdf/473445/20260326-306793-2mehor.pdf

In an adolescent rat model of vaped THC exposure, early abstinence impaired their memory performance but this was rescued by citicoline (a brain chemical & dietary supplement)
Prior cannabis vapor exposure impairs pattern separation in rodents of multiple ages but is rescued by citicoline administration
https://www.sciencedirect.com/science/article/pii/S0306452226002101

In a rat model of prenatal CBD exposure, the litter size was reduced & as adolescents, they were more hyperactive & in females, more risk-taking
Prenatal cannabidiol exposure alters physical and behavioral development in rats
https://www.sciencedirect.com/science/article/abs/pii/S0892036226000164

🐁 Preclinical 🐁

In a mouse model of Parkinson’s disease, both CBD & THC individually & in combination caused antidepressant-like effects & significantly elevated brain dopamine levels
Antidepressant-like Effects of Cannabidiol and Tetrahydrocannabinol in a Reserpine-induced Mouse Model of Parkinson’s Disease
https://hal.science/hal-05570890/

In a mouse model of acute lung injury, CBD reduced inflammation & suppressed the immune system response of neutrophils & macrophages
Cannabidiol hinders lipopolysaccharide-induced neutrophils migration to the lungs through suppressing nuclear factor kappa-B signal and expression of interleukin-1 beta in macrophages
https://www.sciencedirect.com/science/article/abs/pii/S0944711326003570

In a rat model of inflammation, CBD-rich cannabis extracts not only failed to inhibit the inflammatory response but may have even exacerbated it
Evaluation of Anti-Inflammatory Effects of Cannabis sativa Extracts via Possible Modulation of mRNA Levels of Inflammatory Cytokines and Cannabinoid Receptors
https://www.mdpi.com/2072-6643/18/7/1106

In a rat model of orofacial neuropathic pain, CBD, CBG & full-spectrum extract all worked in females, but males responded only to the CBG & full-spectrum extract
Cannabinoid Modulation and Sex Differences in Orofacial Neuropathic Pain
https://www.jpain.org/article/S1526-5900(25)01339-2/abstract

In a rat model of neuropathic pain & a tolerance to opioids, CBD reduced their mechanical hypersensitivity & partially counteracted the metabolic dysregulation
Cannabidiol (CBD) modulates the serotonin–kynurenine metabolic balance in the brain of morphine-tolerant neuropathic rats
https://link.springer.com/article/10.1007/s43440-026-00850-w

In mice taking oxycodone, CBD inhibited the breakdown of oxycodone, increased exposure by 3X & extended painkiller efficacy, possibly mediated by the liver enzymes CYP2D6 & CYP3A4
Behavioural, pharmacokinetic, and genetic evidence of a cannabidiol-oxycodone drug-drug interaction in mice
https://www.sciencedirect.com/science/article/pii/S0753332226003100

In a rat model of phantom limb pain, given prophylactically, either THC or CBD+ beta caryophyllene reduced onset & severity, while with delayed treatment, the most effective were CBD+THC+ beta caryophyllene or CBD+ beta caryophyllene, working via GABA (the brain’s most common inhibitory neurotransmitter) in the spinal cord
Targeting Phantom Limb Pain with Cannabinoids in a Rat Model
https://karger.com/mca/article-pdf/doi/10.1159/000551763/4522754/000551763.pdf

In a rat model of cerebral ischemia-reperfusion injury (blood flowing back into the brain after a block), the terpene beta caryophyllene caused neuroprotection
High-Throughput RNA Sequencing Identifies Hub Genes and Anti-inflammatory Effects of β-Caryophyllene in Cerebral Ischemia-Reperfusion via p38MAPK/NF-κB Modulation
https://www.sciencedirect.com/science/article/pii/S0361923026001437

In a fruit fly model of ALS, on the benefits from both a mixture of flavonoids + terpenes as well as Cannaflavin A
Transcriptomic Effects of Cannabis-Derived Therapies in a Drosophila model of ALS
https://storage.prod.researchhub.com/uploads/papers/users/79414/f704d059-6796-43a1-af55-c5bf3e0bea06/Drosophila%20Manuscript%20-%20Canurta%2012-03-2026.pdf

In a rat model of exercise helping depression, running improved the levels of CB1 receptors in an area of the prefrontal cortex, which was associated with improved behavior
Medial prefrontal cortical CB1Rs and astrocytes are involved in depression and the antidepressant effects of running exercise in male rats
https://www.sciencedirect.com/science/article/abs/pii/S016503272600546X

🆕 Novel Studies 🆕

(a grab bag section for cool & new stuff)

In northern China, the first identification of cannabis phytoliths (plant fossils) from 4500 years ago with evidence that the plant was well integrated into local agricultural economy
Integrating cannabis into the prehistoric crop assemblage: Phytolith evidence from Shandong, Northern China (4500-3400 BP)
https://www.sciencedirect.com/science/article/abs/pii/S0305440326000750

For eyewitness testimony watching a mock crime, cannabis users did not differ for memory performance, but intoxication caused inflated confidence when making errors in identifying someone in a lineup
Cannabis intoxication does not impair eyewitness recall with the Sketch Cognitive Interview but increases confidence in lineup errors
https://www.nature.com/articles/s41598-026-45069-0_reference.pdf

In the US since 2010, adolescents referred to cannabis treatment programs by the criminal legal system decreased substantially
Decreasing criminal legal system referrals to cannabis treatment in the US: Adolescent trends by race and ethnicity between 2010-2022
https://www.sciencedirect.com/science/article/pii/S0749379726000942

[AI policy analysis] For states with automatic cannabis record expungement, this raised average monthly Black earnings by 6.8% & White earnings by 3.9%
The Expungement Dividend: Automatic Marijuana Record Clearing and Black Labor Market Outcomes
https://ape.socialcatalystlab.org/papers/apep_0714/v1/paper.pdf
I’ve never seen this before, but apparently this paper from the Autonomous Policy Evaluation Project is part of their effort to create automated policy evaluations. I don’t know if you can trust it, but I’m glad to know it exists.

📰 US Headlines & Fav Articles

Medicare & Medicaid Services (CMS) announced their plan to cover up to $500 worth of hemp-derived products each year for eligible patients
https://www.marijuanamoment.net/dr-oz-announces-launch-of-program-covering-hemp-thc-and-cbd-products-through-medicare/
And the head of the FDA quickly said they won’t enforce the CBD laws against this program (because it clearly contravenes them)
https://www.marijuanamoment.net/new-fda-enforcement-memo-clears-way-for-hemp-cbd-product-coverage-under-new-medicare-plan/
And a lawsuit by anti-cannabis demonstrators to immediately block this Medicaid plan was denied, but hearings are scheduled for 4/20
https://www.marijuanamoment.net/judge-rejects-anti-marijuana-groups-motion-to-block-cbd-and-thc-medicare-coverage-plan-setting-hearing-for-4-20/

In Colorado, healthcare facilities can now let terminally ill patients use medical cannabis, though the governor criticized the bill for allowing organizations to opt out
https://www.marijuanamoment.net/colorado-governor-signs-bill-to-allow-medical-marijuana-use-in-hospitals-but-criticizes-amendment-letting-facilities-opt-out/

A profile of Mark Pedersen, a man who was persecuted for treating chronically sick children with medical cannabis
https://www.esquire.com/news-politics/a70626609/mark-pedersen-jack-splitt-death-trial-cannabis-herculaneum-missouri/

🌐 International Updates 🌐

In Costa Rica, the first transfer of pharmaceutical-grade cannabis to the EU
https://cannabislaw.report/costa-rica-grower-ships-1st-export-of-gacp-certified-medical-cannabis-to-the-eu/

⚖️ Business, Laws & Education ⚖️

In the Zürich adult-use cannabis sales trial, variations in sales conditions had only a small impact on purchase behavior
Variations in Regulated Cannabis Sales Conditions and Their Effect on Purchase Behaviour: Findings from an Observational Study
https://karger.com/ear/article-pdf/doi/10.1159/000551031/4523383/000551031.pdf

For youth exposed to cannabis advertising, on the features most associated with fun, health or danger
How Do Cannabis Ads Influence Youth Perceptions of Cannabis?
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2645776

🚓 The War on Drugs 🚓

For designating drug cartels as terrorist organizations, a review of the military implications
Military Implications of Designating Drug Cartels as Foreign Terrorist Organizations and Specially Designated Global Terrorists: A Systematic Literature Review
https://www.researchgate.net/publication/403021200_Military_Implications_of_Designating_Drug_Cartels_as_Foreign_Terrorist_Organizations_and_Specially_Designated_Global_Terrorists_A_Systematic_Literature_Review

In Bolivia, on the innovative policies for the defense of the coca leaf & the rights of cocoa growers
Social Control of Coca Production: Lessons from the Tropic of Cochabamba, Bolivia
https://jied.lse.ac.uk/articles/10.31389/jied.292
And for Peru’s largest coca eradication campaign, it reduced schooling among children by ~1.5 years
Coca is gone: Evaluating the unintended consequences of crop eradication on educational outcomes in a former cocaine enclave in the Upper Peruvian Amazon
https://www.sciencedirect.com/science/article/pii/S0955395926001052

In the Mexican War on Drugs, a thesis project focusing on the mothers of the disappeared trying to reclaim the bodies of their children
Entanglements Of Sovereignties: Searching Mothers, Criminal Organizations And The State Apparatus Amid The Mexican War On Drugs
https://utoronto.scholaris.ca/server/api/core/bitstreams/bc72cbce-3589-4404-8ecc-21ab47d6ea9e/content

In the trials of drug couriers, how gendered narratives shape the outcomes
FROM VICTIM TO VILLAIN: HOW GENDERED NARRATIVES SHAPE DRUG COURIER TRIALS
https://digitalcommons.tourolaw.edu/cgi/viewcontent.cgi
“This is not just a movie plot, although it is exactly what happens in Maria Full of Grace, the 2004 film that brought global attention to the role of female drug mules. It is also real life for countless women across Latin America and beyond. Women who are in vulnerable situations: poor, young, isolated, are often targeted by traffickers who know how to exploit desperation. … But once these women are caught, their stories often vanish. In the courtroom, they are no longer seen as desperate or coerced. Instead, they are framed as either careless or cunning, naïve victims who should’ve known better or cold operators who knew exactly what they were doing.”

On the creative smuggling tactics to get drugs across the US border
https://san.com/cc/hidden-in-toys-food-and-freight-cartels-adapt-to-get-drugs-across-the-us-border/

In Uzbekistan, potatoes used to smuggle 72 kg of hashish
https://cannabislaw.report/mash-it-up-uzbekistan-foils-hashish-smuggling-hidden-in-potato-truck/

In Kenya, a poetic court case where a man defending his cannabis cultivation said that he did it because they are beautiful
https://cannabislaw.report/kenyan-court-cannabis-vs-roses/
“When asked by the Magistrate, why he didn’t grow roses instead, Kiprotich replied: ‘I stay away from roses because they attract women. I am not ready for the drama and complications that come with women right now. I prefer solace and the scent of my cannabis. They don’t ask me for anything, they just give me peace of mind’.”

For drug use & its criminalization, a perspective based on Kant
Kantian Perspectives on Drug Use and Drug Criminalization
https://www.tandfonline.com/doi/pdf/10.1080/0731129X.2026.2644079

🚗 Driving 🚗

For driving under the influence of cannabis, police data from Pennsylvania found legalization in a neighboring state increased a county’s rate of crashes involving a cannabis-positive driver
The effects of recreational marijuana legalization on driving under the influence of marijuana in a neighboring state: A cross-border quasi-experiment
https://www.sciencedirect.com/science/article/pii/S0022437526000472

🛡️ Harm Reduction News 🛡️

For the involuntary treatment of substance use disorders, the Canadian Society of Addiction Medicine made a statement against it, though they do say “there is a lack of high-quality evidence to either support or refute this approach to care”
Canadian Society of Addiction Medicine Position Statement on Involuntary Treatment
https://journals.lww.com/cja/fulltext/2026/03000/canadian_society_of_addiction_medicine_position.3.aspx

In Missouri, on the dangers of prisons for people with substance use disorders because of receiving punishment instead of treatment
https://www.themarshallproject.org/2026/03/05/st-louis-missouri-prison-opioid-addiction-lawsuit

Harm Reduction Research

For the parental use of psychoactives, a special issue on a harm reduction approach
Reimagining Support for Parenting in the Context of Parent Psychoactive Substance Use: A Harm Reduction Approach
https://www.tandfonline.com/doi/pdf/10.1080/15295192.2025.2605463

On a mobile Welsh harm reduction known as Spike on a Bike
Spike on a bike: mobile harm reduction in action
https://link.springer.com/article/10.1186/s12954-025-01394-7

For veterans, on the efficacy of harm reduction supply vending machines
Meeting Veterans Where They Are: Harm Reduction Supply Distribution via Vending Machines
https://journals.sagepub.com/doi/abs/10.1177/29767342261426185

For the drug decriminalization in British Columbia, interviews & data found limited help for unhoused or structurally vulnerable individuals
Public drug use, policing, and the limits of decriminalization in British Columbia: A mixed methods study
https://www.sciencedirect.com/science/article/pii/S0955395926001027
And that the barriers to health & harm reduction services persisted
Access to health and harm reduction services during drug decriminalization in British Columbia, Canada: a mixed-method study
https://link.springer.com/article/10.1186/s12889-026-26978-1
And an AI analysis found widespread public confusion
Detecting Misconception Surges in Opioid Policy: A Zero-Shot LLM Analysis of British Columbia’s Decriminalization Pilot
https://assets-eu.researchsquare.com/files/rs-8897658/v1_covered_1137d5a4-47be-4ada-bbf7-0e21a0952b2b.pdf

For sexual minority people attempting to access addiction treatment services, a review of 62 studies on their barriers
Barriers and facilitators to accessing addiction treatment services for sexual minority(LGBQ+) people: systematic review
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/AF67B6EFE324EE587A8830F87B90355E/S0007125026105893a.pdf/barriers-and-facilitators-to-accessing-addiction-treatment-services-for-sexual-minority-lgbq-people-systematic-review.pdf

🍄 Psychoactives, Psychedelics & Plant Medicines 🍄

An experiment of scientists using LSD to solve their most difficult problems, with a focus on Merlin Sheldrake of ‘Entangled Life’ fame

David Luke

6 months ago · 19 likes · 10 comments · David Luke

A personal story of using ibogaine to treat trauma at the Ambio clinic in Mexico
https://www.nytimes.com/2026/03/01/magazine/ibogaine-psychedelic-treatment-trauma-mental-health.html

For finding new drug names, on the use of a language model combing the Internet
What’s new on the market? Combining internet traces and pretrained language models to recognize emerging drug names
https://www.sciencedirect.com/science/article/pii/S0379073826001453

Psychedelics & MDMA

In people with depression, intranasal 5-MeO-DMT caused rapid & sustained reductions
Intranasal 5-MeO-DMT Concomitant with SSRI for Treatment-Resistant Depression: A Proof-of-Concept Trial
https://link.springer.com/article/10.1007/s40263-025-01250-z

For people on Reddit using psychedelics for mental health, a survey of their themes
“I can objectively view my trauma without feeling like I’m there”: Reddit discussions on self-reported use of psychedelics to address co-occurring substance use and mental health needs
https://akjournals.com/view/journals/2054/aop/article-10.1556-2054.2026.00487/article-10.1556-2054.2026.00487.xml
“Thematic analysis revealed positive experiences with psychedelics, including symptom relief for anxiety, depression, and PTSD, along with enhanced mood, inner peace, emotional healing, and shifts in perspective. These experiences were linked to reprocessing trauma and disrupting negative thought cycles. Users highlighted the potential for psychedelics to support long-term recovery from opioid use by fostering emotional resilience and clarity.”

For psilocybin, a case report of someone with cardiac arrest after eating a psilocybin-chocolate bar
26-CCC-15854-ACC TALK ABOUT A BAD TRIP!: PSILOCYBIN USE WITH PRE-EXISTING CARDIOVASCULAR DISEASE, A CASE REPORT
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3249

For an IV of DMT, on the pharmacokinetics
Dose-dependent pharmacokinetics and acute effects of intravenous bolus N,Ndimethyltryptamine: double-blind, randomized versus open-label dose-escalation administration study in healthy participants
https://www.nature.com/articles/s41398-026-03987-7_reference.pdf

For mescaline & psychiatric disorders, a review of 10 studies found help for “depression scales, well-being, nicotine dependence, alcohol use, and obsessions”
The Ethnopharmacological Use of Mescaline for Psychiatric Disorders: A Systematic Review
https://www.mdpi.com/1422-0067/27/7/3081

In people with depression, a review of 13 trials found mystical-type experiences linked to improvements in anxiety and/or depression outcomes
A scoping review of mystical-type experiences and mood symptom outcomes in psychedelic therapy clinical trials: comparing life-threatening disease and depressive populations
https://journals.sagepub.com/doi/pdf/10.1177/20451253261433836

For cancer pain, a review of using psychedelics
Psychedelics; an untapped therapeutic niche: a narrative review in the future of cancer pain management
https://www.sciencedirect.com/science/article/pii/S2590098626000102

For co-occurring PTSD & a substance use disorder, a review on the potential of MDMA-assisted therapy
MDMA-assisted therapy for PTSD and Substance Use Disorders: A Scoping Review of Feasibility and Future Directions
https://www.sciencedirect.com/science/article/pii/S295048482600007X

For adolescents with treatment-resistant mental health diseases, a commentary on the potential of psychedelic medicine
Classic psychedelic medicines for adolescent refractory mental health disease
https://akjournals.com/view/journals/2054/aop/article-10.1556-2054.2026.00452/article-10.1556-2054.2026.00452.xml

For derivatives of LSD, computer modeling of their potential toxicity
The toxicity of psychedelic LSD derivatives: 1-acetyl-LSD (ALD-52), 1-propionyl-LSD (1P-LSD), 1-butyryl-LSD (1B-LSD), 1-valeryl-LSD (1V-LSD) and 1-cyclopropylmethanoyl-LSD (1cP-LSD)—prediction of toxicological parameters relevant to clinical and forensic toxicology using multi-in silico approach
https://link.springer.com/article/10.1007/s00204-025-04255-1

Ketamine

For the self-described therapeutic use of ketamine, an analysis of Reddit posts
Ketamine Use in Self-Described Therapeutic Contexts: A Thematic Analysis of Reddit Posts
https://www.mdpi.com/2076-328X/16/4/480

For people with opioid use disorder, a combination of ketamine & Mindfulness-Oriented Recovery Enhancement (MORE) lowered cravings & opioid use
Ketamine-assisted Mindfulness-Oriented Recovery Enhancement for opioid use disorder: a randomized controlled trial
https://www.nature.com/articles/s44220-026-00625-5

For pain, on combining yoga & ketamine
Integrating Yoga Therapy and Ketamine Therapy for Chronic Pain Management
https://www.jpain.org/article/S1526-5900(25)01111-3/abstract

Kratom

For kratom, public health data on the increases in reports to the US National Poison Data System over the last 10 years
Increases in Kratom-Related Reports to Poison Centers — National Poison Data System, United States, 2015–2025
https://www.cdc.gov/mmwr/volumes/75/wr/mm7511a1.htm

A case report of kratom-induced liver injury
Kratom Consumption Associated With HerbInduced Liver Injury and a Pharmacokinetic Interaction: A Case Report
https://assets.cureus.com/uploads/case_report/pdf/478215/20260328-330966-25ul23.pdf

A case report as kratom as a trigger for arrhythmia problems
26-CCC-10170-ACC KRATOM AS A POTENTIAL TRIGGER FOR BRUGADA TYPE 1 ECG PATTERN AND ARRHYTHMIC SYNCOPE
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3178
And another
26-CCC-8308-ACC KRATOM: A DEADLY OUTCOME
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3158
And a case of heart failure
26-CCC-15323-ACC KRATOM-INDUCED CARDIOMYOPATHY: A RARE CAUSE OF REVERSIBLE HEART FAILURE
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3755

In withdrawal from kratom, a case report of cardiovascular toxicity
26-CCC-15620-ACC BEYOND NATURAL: TAKOTSUBO CARDIOMYOPATHY FROM KRATOM WITHDRAWAL
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3763

Cathinones

In France, cathinone use on the rise among people attending harm reduction facilities
The rising wave of cathinone use in people attending harm reduction facilities: a French repeated cross-sectional study (2019–2023)
https://link.springer.com/article/10.1186/s13722-026-00655-5

🍃 The Plant & its Products 🍃

🌱 Growing 🌱

On the effects of different light spectra on cannabis yield, mineral content & pigment levels
Effects of Green Light Deprivation and Red-to-Blue Ratio on Growth, Mineral Content, and Pigments in Salvia officinalis L. and Cannabis sativa L.
https://www.mdpi.com/2223-7747/15/7/1004

In different hemp germplasms, on evaluating their resistance to downy mildew (caused by Pseudoperonospora cannabina)
Evaluation of downy mildew resistance in the USDA Hemp Germplasm Repository using high-throughput and traditional phenotyping methods
https://apsjournals.apsnet.org/doi/abs/10.1094/PDIS-09-25-1916-RE

For cannabis flower development, an analysis of the transcribed genes
Transcriptomic insights into unisexual flower development in Cannabis sativa: conserved MADS-box networks and divergent developmental programs
https://link.springer.com/article/10.1186/s12870-026-08639-y

For the terpene synthesis enzymes of cannabis, a genetic & functional analysis
Expansion and functional diversification of terpene synthases shape volatile terpenoid landscape in Cannabis sativa
https://www.sciencedirect.com/science/article/pii/S2211383526001942

⚙️ Extracting, Analyzing & Formulating ⚙️

For the thermal breakdown of CBD & THC, computer modeling of their breakdown products with a focus on risk
Computational Modeling of Cannabidiol and Δ⁹-Tetrahydrocannabinol Derivatives from the Thermal Degradation of Cannabis sativa
https://www.acapublishing.com/dosyalar/baski/BEN_2025_1062.pdf

For CBD isolate formulated as an encapsulated powder emulsion, it caused significantly increased bioavailability compared to the Epidyolex oil
Comparative Pharmacokinetics and Safety of Cannabidiol in a Powder Formulation, CBtru®, vs an Oil-Based Formulation, Epidyolex®, Under Fasted and Fed Conditions in Healthy Participants: A Randomized Open-Label Cross-Over Phase I Study
https://link.springer.com/article/10.1007/s40263-026-01280-1

Evaluation of polymeric micelles with full-spectrum hydrophobic cannabis compounds
Physicochemical characterization of Pluronic® polymeric micelles for the aqueous compatibilization of full-spectrum hydrophobic compounds from Cannabis sativa
https://www.sciencedirect.com/science/article/abs/pii/S0167732226002862

🍞 Food & Nutrition 🍞

On using hempseed protein as a meat substitute
Hemp seed protein: a promising meat protein substitute with high nutritional value, high safety, and high meat like aroma characteristics
https://www.sciencedirect.com/science/article/abs/pii/S0308814626011787

🏗️ Industrial Uses & Fiber 🏗️

On creating noise barriers from recycled plastic, rubber granules & hemp shive panels
Development of Noise Barrier Made from Recycled Plastic and Rubber Granule Hemp Shive Panels
https://www.mdpi.com/2075-5309/16/7/1294

For food packaging, on creating nanocomposites films with hemp nanocellulose & zinc oxide nanoparticles
Synergistic reinforcement of alginate films with hemp nanocellulose and ZnO nanoparticles for enhanced mechanical, barrier, and antimicrobial performance
https://www.sciencedirect.com/science/article/abs/pii/S0141813026016272

For food packaging, on creating films using hemp essential oils for antioxidant & antimicrobial effects
Hemp Essential Oils as Novel Antioxidant and Bacteriostatic Agents in PLA-Based Packaging
https://www.mdpi.com/2073-4360/18/7/824

On converting hemp pomace (a byproduct of hemp oil production) into high-value products such as protein-enriched feed & industrial relevant enzymes
Valorization of Hemp Oil Pomace by Thermomyces lanuginosus for the production of value-added products
https://www.croris.hr/crosbi/publikacija/prilog-skup/935920
Conversion of Hemp Seed Oil Pomace into Value-Added Products
https://www.croris.hr/crosbi/publikacija/prilog-skup/935933

On creating curved beams with hemp fiber-reinforced laminated composites
Free Vibration of Hemp Fiber‐Reinforced Laminated Composite Curved Beams Using Generalized Differential Quadrature Method
https://4spepublications.onlinelibrary.wiley.com/doi/pdf/10.1002/pc.71022

On creating fire-resistant panels with hemp insulation
eNUCPUIR: Establishing patterns in the formation of a fire-resistant sip panel with hemp insulation
https://repositsc.nuczu.edu.ua/handle/123456789/28040

On adding hemp to biodegradable plastic composites via micro injection moulding
Optimizing Synergistic Reinforcement in PLA Composites: An Analysis on Hybrid Hemp-Sisal Fiber Loading Using Micro Injection Moulding (MIM)
https://iopscience.iop.org/article/10.1088/2631-8695/ae5922/meta

In mortar, hemp shives raised porosity & lowered strength but improved insulation
Comparative assessment of hemp shiv and basalt fibre reinforcements in lime-based mortars for sustainable building and heritage-compatible applications
https://www.sciencedirect.com/science/article/pii/S0950061826010494

For hemp fiber, on the best solvents for good wet spinning
Preparation and structure–property regulation of seed-type hemp-based regenerated cellulose filaments in a LiCl/DMAc solvent system
https://www.sciencedirect.com/science/article/pii/S0926669026005480

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

For undergraduate organic chemistry students, on a teaching lab experiment on converting CBD to CBN using a one-pot reaction
From CBD to CBN: A Small-Scale, Project-Like Undergraduate Organic Lab Experiment Integrating Chemical Synthesis, TLC Co-spotting, Dry Column Vacuum Chromatography, and Antibacterial Testing
https://pubs.acs.org/doi/abs/10.1021/acs.jchemed.5c01541

🏥 Public Health & Bioassays 🏥

In older adults using medical cannabis, in interviews they described frequent use, self-experimentation because of a lack of guidance, replacing other medications with it & few had any concerns about cannabis use disorder, although one-third screened positive for it
Behaviors Related to Medical Cannabis Use in Older Adults: A Qualitative Study
https://www.tandfonline.com/doi/pdf/10.1080/02791072.2026.2644852

For US people using cannabis, a survey found one-third used medically, one-third recreationally & one-third for recreational & medical reasons
Reasons for Using Cannabis Among Adults in the United States: Associations with Demographics, Health Behaviors, Chronic Conditions, and Legal Status
https://www.mdpi.com/1660-4601/23/4/421

For people who used cannabis from adolescence through adulthood, on the related factors
An Ecological View of Adolescent Factors That Influence Cannabis Use from Adolescence to Midlife
https://www.tandfonline.com/doi/pdf/10.1080/29973368.2026.2644241

For the pediatric prescribing of CBD in the United States, a health record analysis
Prevalence of pediatric cannabidiol prescribing in the United States
https://link.springer.com/article/10.1007/s12519-026-01028-3

In older people with a disability, public health data found higher odds of nicotine-cannabis co-use
Poly-Substance Use of Nicotine, Alcohol, and Cannabis Among Adults Aged 50 and Older with Disability: Analysis of 2020–2022 Behavioral Risk Factor Surveillance System Data Across 33 U.S. States
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2647128

In Ugandan medical students, cannabis use was common
Cannabis Use Among Ugandan Medical Students: Prevalence, Predictors, and Coping Strategies in a Cross‐Sectional Study
https://onlinelibrary.wiley.com/doi/pdf/10.1002/brb3.71325

In monkeys, on the pharmacokinetics of oral THC
Pharmacokinetics of oral Δ9-tetrahydrocannabinol (THC) administration in vervet monkeys
https://link.springer.com/article/10.1186/s42238-026-00422-y

For screening saliva for THC, on a smartphone-based detection system
An immobilization-free aptamer-based liquid sensing display for the label-free detection of illicit Δ9-tetrahydrocannabinol
https://www.sciencedirect.com/science/article/abs/pii/S0039914026003966

In blood & dried blood spots, a comparative stability analysis of synthetic cannabinoids
Comparative Stability Assessment of Synthetic Cannabinoids in Dry Blood Spots and Blood using UHPLC-MS/MS: Implications for Forensic Applications
https://www.tandfonline.com/doi/abs/10.1080/15376516.2026.2652433

🧒 Adolescents & Young Adults 🧒

For US adolescents who used cannabis, those who reported it being recommended by a healthcare professional had more frequent use & were more likely to meet the criteria for cannabis use disorder
Medically Recommended Cannabis Use for US Adolescents
https://www.sciencedirect.com/science/article/abs/pii/S074937972600098X

For adolescents, medical & adult-use legalization was associated with positive cannabis attitudes
Cannabis legalization and early adolescent expectancies: Findings from the adolescent brain cognitive development study
https://www.sciencedirect.com/science/article/pii/S0376871626001195

In young adults from Washington State, they tended to use cannabis & alcohol heavily on the same days, but heavy use of cannabis (daily or near daily) was associated with less drinking
Nonmonotonic associations between cannabis use frequency and alcohol use in a statewide sample of young adults from Washington State
https://www.sciencedirect.com/science/article/abs/pii/S0749379726000966

🧠 The Brain & Neurological Disorders 🧠

For cannabinoid extraction & neurodegenerative protein spectroscopy, on a new unified laboratory system
An Integrated Multi-Variable Analytical Framework for Coupled Cannabinoid Extraction and Neurodegenerative Protein Spectroscopy in a Unified Laboratory System
https://www.researchgate.net/profile/Joshua-Animasaun-2/publication/403245893_An_Integrated_Multi-Variable_Analytical_Framework_for_Coupled_Cannabinoid_Extraction_and_Neurodegenerative_Protein_Spectroscopy_in_a_Unified_Laboratory_System/links/69c81e3e3c6189430670cce7/An-Integrated-Multi-Variable-Analytical-Framework-for-Coupled-Cannabinoid-Extraction-and-Neurodegenerative-Protein-Spectroscopy-in-a-Unified-Laboratory-System.pdf

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

In adults using medical cannabis, the factors associated with possible cannabis use disorder were younger age, prolonged daily use, a preference for inhalation methods & recreational motives for cannabis use
Factors Associated with Possible Cannabis Use Disorder among Adults Using Medical Cannabis in Florida: A Cross-sectional Study
https://karger.com/mca/article-pdf/doi/10.1159/000550537/4522900/000550537.pdf

In Australian adults admitted to an acute psychiatric unit, the main reason for a medical cannabis prescription was anxiety, though the majority were admitted for psychosis
Medicinal Cannabis Prescription Before an Inpatient Psychiatric Admission: A Retrospective Observational Audit
https://journals.lww.com/practicalpsychiatry/abstract/2026/03000/medicinal_cannabis_prescription_before_an.2.aspx

In a mouse model of opioid use disorder, those without a CB1 receptor had an enhanced rewarding effect from morphine but no stress-induced reinstatement
Involvement of the cannabinoid system in stress-induced reinstatement to opioid use: a study in CB1 knockout mice of both sexes
https://www.sciencedirect.com/science/article/abs/pii/S0014299926002839

🧬 Reproduction & Hormones 🧬

In a mouse model of embryonic aluminum exposure impairing male offspring development & fertility, one of the pathways triggered is overactivation of the CB1 receptor
A novel adverse outcome pathway in aluminum-induced male infertility: Oxidative stress-mediated endoplasmic reticulum stress and endocannabinoid system activation delineated by network toxicology and metabolomics
https://www.sciencedirect.com/science/article/pii/S0147651326003891

🦠 The Immune System & Microbial 🦠

In people with HIV, cannabis users had lower levels of the inflammatory C-reactive protein
Associations Between Cannabis Use and Inflammatory Biomarkers Among People with HIV
https://journals.sagepub.com/doi/abs/10.1177/25785125261437619

🦴 Pain, Musculoskeletal, Inflammation & Surgeries 🦴

In older adults with chronic pain, those who intended to start using medical cannabis reported higher pain severity, pain interference & lower sleep quality
Factors Associated with Intention to Initiate Medical Cannabis Among Older Adults with Chronic Pain in a Prospective Cohort
https://www.jpain.org/article/S1526-5900(25)01196-4/abstract

In people with sickle-cell disease, cannabis users had higher odds of experiencing moderate to severe pain
Associations Between History of Cannabis Use, Pain, and Acute Care Outcomes
https://www.jpain.org/article/S1526-5900(25)01356-2/abstract

In people with a chronic post-surgical pain (which affects 20 to 40% of surgical patients), those who were using cannabis scored higher for perceived distress, but no other differences in psychological measures
Exploring the Influence of Cannabis Use in Patients with Chronic Post-Surgical Pain
https://www.jpain.org/article/S1526-5900(25)01394-X/abstract

In people with chronic pain, their insomnia status was not associated with their cannabis use or cannabis use disorder risk
Insomnia in Chronic Pain and Its Relation to Cannabis Use Patterns and Cannabis Use Disorder Risk
https://www.jpain.org/article/S1526-5900(25)01373-2/abstract

In a mouse model of skeletal muscle regeneration, a lack of CB2 receptors caused more inflammation & impaired muscle repair
Cannabinoid type 2 receptor regulates skeletal muscle regeneration by NLRP3-GSDMD mediated macrophage pyroptosis after injury
https://www.nature.com/articles/s41420-026-03077-z_reference.pdf

In a mouse model of opioids causing a hypersensitivity to pain, a drug that acted as a positive allosteric modulator of the CB1 receptor (making other drugs bind their more strongly) lowered their hypersensitivity, while chronic blocking of the MAGL enzyme (which breaks down 2-AG) did the same via the CB2 receptor
Endocannabinoid Approaches to Reducing Opioid-Induced Allodynia
https://www.jpain.org/article/S1526-5900(25)00969-1/abstract

In a female rat model of medication overuse headache, inhibition of ABHD6 (an endocannabinoid transporter) lessened pain, probably not via the CB1 receptor
Endocannabinoid Signaling in Medication Overuse Headache
https://www.jpain.org/article/S1526-5900(25)01343-4/abstract

❤️ The Heart & Blood ❤️

All the data from the site “jacc.org” is from this year’s American College of Cardiology conference (there’s more in the kratom & psychedelic sections above). I certainly do not mind their focus on the negative heart effects of cannabis, but I do resent their poster titles with lousy stoner puns.

For people who had heart attacks, public health data showed that the ones with THC in their system were younger & had lower in-hospital mortality, shorter hospital stays & less need for advanced support
26-CVT-15549-ACC TETRAHYDROCANNABINOL EXPOSURE AND IN-HOSPITAL OUTCOMES IN ACUTE MYOCARDIAL INFARCTION: A NATIONAL INPATIENT SAMPLE ANALYSIS
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3127

In 3 young chronic cannabis using males with no other cardiovascular risk factors, case reports on their acute coronary syndromes
26-CCC-8309-ACC BETWEEN JOINTS AND HEARTBREAKS: FROM PUFF TO PAIN, EXPLORING MARIJUANA’S IMPACT IN ACUTE CORONARY EVENTS
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3336

For a blocked heart, a case report of someone with a significant cannabis history
Suspected Cannabis-Induced Acute Coronary Syndrome and Advanced Heart block
https://journals.sagepub.com/doi/pdf/10.1177/23247096261435473

A case report of a chronic cannabis user with prolonged sinus arrest (failure of a heart beat signal)
26-CCC-16622-ACC THE JOINT THAT STOPPED THE BEAT: SINUS ARREST IN A PATIENT WITH CHRONIC MARIJUANA USE
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3266

For vaping cannabinoids, a case report of a rare heart inflammation
26-CCC-11946-ACC FULMINANT EOSINOPHILIC PERIMYOCARDITIS PRESENTING WITH SEVERE, NON-OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY AND CONCOMITANT CARDIAC TAMPONADE LEADING TO MIXED SHOCK AFTER VAPING CANNABINOIDS
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3621

For a young female, a case report of synthetic cannabinoids & a cardiac arrest
26-CCC-18139-ACC ARRHYTHMOGENIC POTENTIAL OF SYNTHETIC CANNABIS: EVIDENCE OF QTC PROLONGATION
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3280

In a mouse model of sickle-cell disease, inhibition of the MAGL enzyme (which breaks down 2-AG) reduced mechanical pain sensitivity & restored motor function
Evaluation of Monoacylglycerol Lipase Inhibition as a Novel Analgesic Strategy in a Humanized Mouse Model of Sickle Cell Disease
https://www.jpain.org/article/S1526-5900(25)01017-X/abstract

🍽️ The Guts, Nutrition & the Microbiome 🍽️

In a mouse model of ulcerative colitis, rectal administration of a combination of CBD & the fatty acid sodium propionate increased colon length, reduced disease scores, lowered body weight loss & lessened damage
A novel enema formulation containing cannabidiol and sodium propionate for ulcerative colitis: preclinical assessment in a murine model
https://link.springer.com/article/10.1186/s42238-026-00400-4

💨 The Lungs 💨

After legalization of cannabis in Massachusetts, there was an increase in young people with pneumomediastinum (air in the space between the lungs)
Trends in Pediatric Pneumomediastinum Following Cannabis Legalization in Massachusetts
https://www.sciencedirect.com/science/article/abs/pii/S0022480426001216

In older mice with lung scarring, activating their CB2 receptor did something behind a paywall…
Therapeutic Potential of CB2 Agonist Osteogenic Growth Peptide in Lung Fibrosis in Aged Mice
https://academic.oup.com/ajrcmb/advance-article-abstract/doi/10.1093/ajrcmb/aanag052/8541984

🎗️ Cancer & Chemotherapy 🎗️

In tumors of the central nervous system, CBD reduced cell viability & migration
Acute Anti-Proliferative and Anti-Migratory Effects of Cannabidiol on C6 Rat Glioma, SH-SY5Y Human Neuroblastoma, and HT22 Mouse Hippocampal Neuronal Cell Cultures
https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2026.1727831/abstract

For anticancer effects, on the creation of a CBD-loaded starch microsphere
Preparation, in vitro digestive release behavior, and anticancer activity of cannabidiol-loaded porous starch microspheres
https://www.sciencedirect.com/science/article/pii/S2772566926001138

For CBD conjugates as antitumor agents, on improving their solubility & antitumor activity
Solubility-Improved and Antitumor Activity of (-)-Cannabidiol Conjugates
https://assets-eu.researchsquare.com/files/rs-9148396/v1/3ee6052c-1a05-4f96-bff1-d145a17d1e5b.pdf

🔬 Biochemical Discoveries & Research Tools 🔬

For the effects of CBD on membranes, on a proposed phase field model
Cannabidiol (CBD) Induces Lipid Microdomain Disruption or Budding in Ternary Mixtures
https://pubs.acs.org/doi/full/10.1021/acs.jpcb.5c06965

For analyzing the CB1 receptor, on advances in chemical probes
Unlocking the Multifaceted Role of CB1R in the Endocannabinoid System with Labeled Chemical Probes
https://www.chimia.ch/chimia/article/view/2026_165

For the minor cannabinoid cannabidiphorol (CBDP) at the CB1 receptor, on how it causes negative allosteric modulations at 2 distinct sites
Cannabidiphorol (CBDP) acts as a negative allosteric modulator at two distinct sites of cannabinoid receptor 1
https://www.nature.com/articles/s42004-026-01990-z

Thanks.
- lex

PS: For this week’s Delta blues, ‘Parchman Farm’, a collection of recordings from the late ‘30s by Bukka White. Born in Mississippi in ~1906, Bukka learned fiddle tunes from his father but once he started playing the guitar, his grandmother didn’t like hearing “that Devil music” in the house (though the music must have been in the blood, because his cousin was BB King). In 1930, a talent scout for Victor recorded 14 of White’s songs but only released 4 of them. With the Great Depression setting in, he didn’t get another chance to record until Big Bill Broonzy invited him to come to Chicago & record for Lester Melrose. But White was in legal trouble for shooting someone in the thigh (he claimed it was self-defense after his friend was ambushed along the highway). He jumped bail & headed to Chicago where he managed to record 2 side before being caught & returned to Mississippi for a 3-year sentence at Parchman Farm.
While he was inside, his song ‘Shake ‘Em Down’ became a hit. Plus, he recorded two songs for the Lomaxes, the famed folklorists who were touring prisons & recording for the Library of Congress. When White got out, he recorded 12 songs for Melrose & these were considered the pinnacle of his recording career, many going on to become classics of the Delta blues. But then, with World War 2 beginning, he started working in a factory & disappeared from public view.
In 1962, when Bob Dylan covered ‘Fixin’ to Die Blues’ on his debut album, blues enthusiasts tracked Bukka White down & he quickly recorded 3 albums of material. Despite being an aging patriarch of the Delta blues, he was a stylish dresser in excellent health who well-enjoyed the folk festival & coffeehouse circuit of the 1960s, where he shared his stories as well as his songs. He stayed on the circuit until his death of cancer at the age of ~71.

This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.
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C&P#182: CBD for seizures & cannabis effects on physical performance & metacognition

Lex Pelger WhiteWhaleCreations — Mon, 30 Mar 2026 10:36:56 GMT

Cannabinoids & The People, or; Drugs & Drug Wars

🌟 This week 🌟

CBD for seizures
On physical performance in cannabis users
Stigma still prevalent against medical cannabis users
Metacognition effects in cannabis users
For first episode psychosis, synthetic cannabinoid use particularly bad
10% of US workers using cannabis at work or right before it
War on Drugs: in prisons, on the rise of synthetic drugs sprayed onto paper & an outbreak of overdoses

(this week’s numbers: ~6.3k words, ~16 minutes reading time, 98 papers)

Hello everyone,
Welcome to the 182^nd edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news as well as coverage of other psychoactives, the War on Drugs & harm reduction. Support this work with a paid subscription or by buying me a coffee. If you purchase one of my canna-graphic novels based on Moby Dick, proceeds go to Americans for Safe Access to support medical cannabis patients.
For producing cannabinoid content, work with my company White Whale Creations: writing, science archives, social media, newsletters & podcasts (especially podcasts).
As always, ask me anything!

📌 Editor’s note 📌:
I just ordered the proof copy of the next 2 chapters of my canna-graphic novels based on Moby Dick. For you handful of fans, get ready!

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Terry Pratchett! (43 years late is better than never…)

And as always, at the bottom is the album of the week: “the most popular female country blues singer of all time”

🧰 Free resources 🧰

CVResearch.info: the cannabinoid science archive I maintain for CV Sciences
My canna-science journalism
My glossary of cannabinoid terms (& containing the legend for my Neural Ocean metaphor with endocannabinoid whales)

Roundup of fav newsletters:
#Canna: Marijuana Moment, Cannabis Law Report, Cultivated, Cannabis Musings (oy vey), Talking Joints Memo, Sticky Bits, Highly Objective, Cannabitch, Indigenous Cannabis Industry Association, Dr. Peter Grinspoon, Doctor Approved, Medical Marijuana Memory Blog (by Dame Alice O’Leary Randall)
#DrugWar: InSight Crime, Marshall Project, Students for Sensible Drug Policy
#HarmReduction: Filter, Drug Data Decoded, International Drug Policy Consortium, National Harm Reduction Coalition, Canadian Drug Policy Coalition
#Psychoactives: Psychedelic Alpha, Ecstatic Integration, ICEERS, Substance, The Microdose

💖 Ways to support this work 💖
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🍃 BEST OF CANNABINOID SCIENCE 🍃

(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)

⚕️ Clinical ⚕️

In children with drug-resistant epilepsies, CBD caused clinically relevant seizure reduction & improved quality of life, especially sleep quality
4CPS-011 Paediatric drug-resistant epilepsies: efficacy, tolerability, and safety of add-on cannabidiol
https://ejhp.bmj.com/content/33/Suppl_1/A55.2
And for treatment-resistant epilepsy, the responders to CBD treatment had increased network integration & network segregation
Global brain network dynamics predict therapeutic responsiveness to cannabidiol treatment for refractory epilepsy
https://d1wqtxts1xzle7.cloudfront.net/132139886/fcaa140-libre.pdf
I’m not strong on brain network dynamics so that last one confused me. But apparently, you can do brain scans to predict how likely CBD is to help someone’s seizures.

For physical performance in adults consuming cannabis, they had higher blood pressure & heart rate as well as impaired balance & endurance
Physical Performance Impairment with Cannabis Consumption in Adults Over 12 Hours
https://journals.sagepub.com/doi/pdf/10.1177/00472379261433203

For the link between cannabis consumption & problematic Internet use, a survey found both positive & negative effects
Cannabis consumption and problematic internet use: analysis of a free-text response collected through a self-reported online questionnaire
https://link.springer.com/article/10.1186/s40359-026-04419-3
“Many reported benefits, such as relaxation, positive emotions, improved mental skills, and pain relief, while others experienced negative impacts, such as increased anxiety, procrastination, social isolation, and impaired cognitive functions. Additionally, these behaviors affected aspects of their daily lives, including finances, sleep, eating habits, and relationships.”

For the effects of psychoactives on metacognition, a meta-analysis found that “cannabinoids generally impaired metacognitive accuracy and calibration”
Experimental and observational evidence on substance use and metacognition among adults: a systematic review
https://www.sciencedirect.com/science/article/abs/pii/S0306460326000808

In frequent cannabis users, they had no cognitive impairments when tested 12 hours after their last ingestion, though the high-THC potency users had poorer verbal memory & processing speed
Cognitive performance and subjective effects the morning after last use of smoked cannabis by adults who use cannabis frequently: An observational study
https://www.sciencedirect.com/science/article/pii/S2772724626000259

For brain volume, a meta-analysis found cannabis users to have smaller amygdala (an emotional processing center)
Associations of cannabis use, tobacco use and co-use with brain volume: A systematic review and meta-analysis
https://onlinelibrary.wiley.com/doi/pdf/10.1111/add.70361

In people with heart failure, public health data found no difference in mortality between cannabis users & non-users
Association of Cannabis use and Survival in patients with heart failure: A claims-based cohort study of commercially insured adults
https://www.sciencedirect.com/science/article/pii/S2666602226000546

In people with schizophrenia, feeding them arachidonic acid (the building block of the endocannabinoid anandamide, which they tend to be deficient in) improved cognitive performance & helped the balance of lipids (fatty acids) in the mitochondria (powerhouse of the cell)
Restoring mitochondrial lipid homeostasis with arachidonic acid supplementation to alleviate cognitive impairment in schizophrenia patients
https://www.sciencedirect.com/science/article/pii/S2090123226002687

For CBD use by small animal veterinarians, a survey found a high frequency of use in dogs & cats, with the most common reason being for cancer, chronic pain, behavioral changes, stress & anti-inflammation
Assessment of Cannabidiol Supplements Use in Small Animals Practice in Portugal
https://onlinelibrary.wiley.com/doi/pdf/10.1111/jpn.70059
“Additionally, in an open‐answer question, some respondents referred to the use of CBDS for other purposes, namely: cognitive dysfunction, appetite stimulant, feline gingivostomatitis, geriatric animals, senility and wound healing. The most frequent adverse effects were hypersialia/sialorrhea (28%; 44/158) and apathy (25%; 39/158)”.

📑 Reviews 📑

On CBD & the mitochondria (powerhouse of the cell), a lovely review on the effects in different diseases (with a set of charts that will make your heart sing)
The Therapeutic Crossroad Between Mitochondria and Cannabidiol: A Mini-Review
https://www.mdpi.com/2079-7737/15/6/510

In Parkinson’s disease, a review of the cannabinoids from preclinical & clinical data (with a nice chart)
Cannabinoids and cognition in Parkinson’s disease: Insights from animal models and emerging clinical evidence
https://www.sciencedirect.com/science/article/abs/pii/S0306452226001971

For osteoarthritis, this review of 19 studies found the strongest data for CBD
The role of cannabis-based medicinal products (CBMPs) in managing osteoarthritis symptoms: a scoping review of current evidence and future directions
https://link.springer.com/article/10.1007/s10067-026-08038-6

In obsessive-compulsive disorder, a review of 13 studies on the involvement of the endocannabinoid system
The Endocannabinoid System in Obsessive-Compulsive Disorder: A Scoping Review
https://www.sciencedirect.com/science/article/abs/pii/S0149763426001120
“Overall, preclinical findings consistently demonstrated that enhancing ECS activity attenuates compulsive and habitual behaviours, whereas inhibiting ECS activity exacerbates these behaviours. The study that utilized both animal and human samples reported reduced expression of genes encoding ECS enzymes and receptors in OCD.”

For aging, a review on the interplay between the endocannabinoid system & reactive nitrogen species (key cellular signal pathway)
Radical Revelations: The Interplay of Nitrosative Stress, the Endocannabinoid System, and Treatment of Age-Related Disorders
https://www.mdpi.com/1422-0067/27/6/2813

⚠️ Harms ⚠️

In people with first episode psychosis, the users of synthetic cannabinoids had higher positive psychotic symptoms, aberrant salience (attributing significance to neutral stimuli) & difficulty feeling emotions compared to natural cannabis users & non-users, while dissociative symptoms were more prominent in any users of cannabinoids & with the synthetic cannabinoid users showing minimal improvement over time
Alexithymia and psychopathological dimensions in First-Episode Psychosis: Comparative patterns in natural cannabis versus synthetic cannabinoid users
https://realmofcaring.org/wp-content/uploads/2026/03/Alexithymia-and-psychopathological-dimensions-in-First-Episode-Psychosis-Comparative-patterns-in-natural-cannabis-versus-synthetic-cannabinoid-users.pdf

For people with cannabis use disorder, a review of the very limited studies of treatment drugs found the only short-term benefits found to be from varenicline
Pharmacological Smoking Cessation Interventions in People with Cannabis, Opioid, or Stimulant Use Disorders: A Systematic Review
https://www.researchsquare.com/article/rs-9141564/v1

In people who had a total abdominal hysterectomy, those with cannabis use disorder (who also tended to be from more marginalized groups & more frequently insured by Medicaid) had longer hospitalization & higher total charges
Comprehensive analysis of cannabis use and dependence in the setting of total abdominal hysterectomy
https://assets-eu.researchsquare.com/files/rs-9058918/v1/a43c0e74-7df5-4606-a5d8-6ff4f4f4fb9c.pdf

In people who had breast surgery, a review of 10 studies found cannabis use associated with increased risk of complications, especially bruising, wound healing & infection risk
Cannabis use and outcomes in breast surgery
https://journals.lww.com/prsgo/fulltext/2026/03000/cannabis_use_and_outcomes_in_breast_surgery.54.aspx

In human blood platelets (involved in clotting & important for transfusions in bleeding disorders), cannabis extracts caused impaired platelet aggregation (clotting)
Pilot study on cannabis-induced alterations in platelet function: implications for transfusion medicine
https://www.tandfonline.com/doi/full/10.1080/09537104.2026.2644368

🐁 Preclinical 🐁

In rats given either THC or CBD, they had significant reductions in their levels of BDNF (a key brain growth factor)
Patterns of BDNF Dysregulation Following Cannabinoid Supplementation in Male Wistar Rats
https://hal.science/hal-05555266/

In a mouse model of an increased risk for schizophrenia, CBD did not alter their responses to cocaine but did reduce cocaine reward in the healthy animals
Cannabidiol (CBD) does not reduce cocaine reward or self-administration in a mouse model of schizophrenia genetic susceptibility
https://www.sciencedirect.com/science/article/pii/S0278584626000722

In a mouse model of navigation & memory, deleting CB1 receptors from the hippocampus (a memory center of the brain) caused emotional changes as well as deficits in memory & synaptic plasticity in both sexes, while in males only, deleting the CB1 receptors on all neurons caused deficits in spatial navigation
Neuroglial CB1 receptors modulate hippocampal processes in a sex-dependent manner
https://link.springer.com/article/10.1186/s13293-026-00886-w

🆕 Novel Studies 🆕

(a grab bag section for cool & new stuff)

For medical advice from budtenders, a survey found “budtender guidance significantly diverged from clinician consensus”
Dispensary Budtender Guidance Versus Clinician Consensus: A Comparative Study of Medical Cannabis Advice
https://www.sciencedirect.com/science/article/pii/S0149291826000470
“Clinicians recommended MC for chronic pain, advised against use during pregnancy, and recommended cautious low–Δ-9-tetrahydrocannabinol regimens for posttraumatic stress disorder. In contrast, many budtenders suggested higher Δ-9-tetrahydrocannabinol dosages or endorsed MC use in pregnancy.” For budtenders, higher cannabis knowledge & less illicit market experience predicted closer alignment with clinician guidance.

An intriguing example of “old-fashioned” electron microscopy helping to resolve a conundrum about the location of CB1 receptors during the current craze for immunofluorescent methods
Accomplishments of “Old-Fashioned” Electron Microscopy in the Period of Dominance of Immunofluorescent Methods
https://www.mdpi.com/1422-0067/27/6/2803#:~:text=2.-,Interpretation%20of%20Anti,-%2DCannabinoid%20Type%201

📰 US Headlines & Fav Articles

Oddly, for the new CBD program by the Centers for Medicare & Medicaid Services, the total container THC limit will be set to 3 mg (~7x higher than the 0.4 mg of THC per container limit set last year in Trump’s spending bill)
https://cannabiswire.com/newsletters/scoop-medicare-cbd-pilot-will-allow-some-thc-in-products/
And reportedly, up to $500 of hemp-derived products will be covered each year
https://www.marijuanamoment.net/feds-detail-plan-to-cover-up-to-500-in-hemp-cbd-and-thc-products-for-medicare-patients-under-program-launching-next-week/

The Department of Homeland Security created a list of the “worst of the worst” of deported immigrants & for 77 of them, their only crime was cannabis possession
https://www.marijuanamoment.net/trump-admins-worst-of-the-worst-deportation-list-includes-nearly-100-immigrants-accused-of-marijuana-possession-alone/

I don’t know if the Army is being cheeky, but starting on 4/20, recruits will no longer need a waiver if they have only one conviction for cannabis or drug paraphernalia possession
https://www.marijuanamoment.net/new-army-rule-allows-recruits-with-a-marijuana-conviction-to-enlist-without-needing-a-waiver-starting-on-4-20/

The Wine & Spirits Wholesalers of America is urging Congress to stop their scheduled ban of hemp THC beverages & regulate them instead
https://www.marijuanamoment.net/alcohol-industry-group-launches-push-to-regulate-hemp-thc-drinks-instead-of-banning-them/

For discrimination in organ transplants against medical cannabis patients, Americans for Safe Access published a new report: “Stigma with a Body Count”
https://www.safeaccessnow.org/report_organ_transplant_discrimination#gsc.tab=0
Relatedly, for stigma against medical cannabis users, a review of 45 studies found little change over time, across jurisdictions & between regulatory regimes
The persistence of stigma and other challenges experienced by medical cannabis users: A thematic synthesis of qualitative studies
https://karger.com/mca/article-pdf/doi/10.1159/000551584/4519200/000551584.pdf

For your international cannabis events, the 10-year-old son of cannabis businessmen Arnaud Dumas de Rauly coded a project to sort all of the world cannabis events by type, region & date
https://cannabislaw.report/ten-year-old-codes-fantastic-new-site-detailing-cannabis-conferences-around-the-world/
This is a very cool project to see from this young man. I hope to someday submit the ‘People of the Cannabinoids’ conference to it.

The WNBA reportedly going to end cannabis testing for players
https://www.marijuanamoment.net/wnba-offers-to-end-marijuana-testing-for-womens-basketball-players-as-part-of-reported-deal-with-union/

On Epstein, an informant apparently told the DEA that he was also running a club drug trafficking network
https://www.bloomberg.com/news/features/2026-03-06/epstein-investigated-in-dea-probe-for-ketamine-money-laundering

In Wisconsin, the governor signed a bill allowing police to administer roadside saliva drug tests, despite the fact that there is no clear link between saliva THC levels & impairment & that levels vary wildly in different people
https://urbanmilwaukee.com/2026/03/19/evers-signs-roadside-drug-test-law-amid-rising-impaired-crashes/

In South Carolina, the DEA is being sued for the unlawful seizure of millions of dollars of inventory from hemp shops
https://cannabislaw.report/news-report-south-carolina-similar-to-hitting-an-ant-with-a-sledgehammer-says-lawyer-low-country-law-firm-sues-dea-over-hemp-shop-raids/

On Project MKULTRA (the CIA mind control drug experiments), an interview with the author of a new book with a focus on interviews of the victims
https://themicrodose.substack.com/p/project-mind-control-5-questions

I’m a bit in love with this former UK member of Parliament. After being caught with a nice mix of drugs (uppers, GBL, weed), he testified in court that he got involved in the chemsex scene as research on the first-hand use of drugs & their harms & now he believes that all drugs should be legal
https://www.hellorayo.co.uk/heat/uk/news/former-surrey-mp-fined-for-possession-of-chemsex-drugs

🌐 International Updates 🌐

Ha. At the UN drug meeting, delegates walked through cannabis smoke by the entrance & the European Times used a ridiculous AI-generated image to illustrate the story
https://cannabislaw.report/media-report-12-march-cannabis-smoke-at-un-drugs-summit-sparks-outrage-in-vienna/

In Japan, CBN will be banned starting June 1, except for limited medical purposes
https://www.japantimes.co.jp/news/2026/03/19/japan/society/cbn-ban/

In Germany, new numbers show it to now be the largest medical cannabis market it outside of North America, but the flood of products has driven down the prices & increased the competition
https://businessofcannabis.com/is-the-german-cannabis-boom-slowing-down-or-simply-normalising/
And relatedly, the German police union does not want cannabis legalization reversed
https://cannabislaw.report/germany-police-union-warns-against-reversal-of-cannabis-legalization/
Their position is more nuanced. The current model of partial legalization relies on a network of cannabis cultivation associations & home grows to supply all of the country’s cannabis needs, but clearly, that will not be sufficient to supply everyone & therefore, the current structure favors illicit trafficking. The police are in favor of a state-controlled market with certified outlets & regulated logistics.

Relatedly, a spokesperson of a German hemp association was fined for giving away 117 cannabis cuttings, with the court deeming them not to be propagation material but full cannabis plants
https://cannabislaw.report/germany-court-ruling-in-halle-higher-fine-in-trial-over-cannabis-cuttings-german-hemp-association-had-intended-to-distribute-free-of-charge-as-part-of-campaign/
And the owner of a cannabis accessory shop got a 6-month suspended prison sentence for offering cuttings of cannabis plants for sale
https://cannabislaw.report/germany-court-ruling-in-bavaria-suspended-prison-sentence-for-grow-shop-owner-over-sale-of-cuttings-in-coconut-peat-mixture/

In Germany 6 months after legalization, a small survey found no increased cannabis consumption
Change and Antecedents of Cannabis Consumption After the Legalization of Recreational Cannabis in Germany
https://journals.sagepub.com/doi/abs/10.1177/00472379261430434

In South Africa, a parliamentary committee is preparing a cannabis omnibus bill for the middle of mid-2027
https://www.cannabiz-africa.com/blog/parliament-and-cannabis-back-to-the-drawing-board-but-this-time-theres-clarity-collaboration-and-commitment

In Uruguay, a survey found cannabis clubs (vs home grows or pharmacies) to be the most common legal source of cannabis but were associated with higher use & increase risk of cannabis use disorder, while those who relied on illicit sources reported greater psychological stress & the use of high-potency cannabis
Patterns of Cannabis Use and Socio-Cognitive Factors of People who Use Cannabis across Cannabis Sources in Uruguay
https://www.scilit.com/publications/522ff28d1eba64fafe93b5158aba96b6

⚖️ Business, Laws & Education ⚖️

For cannabis use & intoxication at work, a survey found that 10% of workers reported using cannabis at work or less than 2 hours before work & of those, 40% reported feeling high at work “often” or “every time”, with the cannabis users having a higher chance of a work-related injury
Self-Reported Cannabis Use and Intoxication at Work: Prevalence Across Industries and Occupations and Association With Workplace Injuries in the United States (US)
https://pubmed.ncbi.nlm.nih.gov/41840876/
“The prevalence of workplace consumption was greatest among those working in the “Agriculture, forestry, fishing and hunting” (24.9%), “Construction” (14.4%), and “Accommodation and food services” (12.6%) industries.”

For cannabis policy, on the potential regulatory models & how the right one may not exist yet
The right schedule for marijuana (among other drugs) does not yet exist
https://www.science.org/doi/pdf/10.1126/science.aec5633

For residential property values in Oklahoma (the state with more medical cannabis dispensaries than any other), “one broad finding is that residents prefer not to live in immediate proximity to a dispensary but prefer access to dispensaries moderately distanced from their home”
Exploring the quantitative impact of medical marijuana dispensaries on residential sale prices in Oklahoma
https://link.springer.com/article/10.1007/s00181-026-02894-6

🚓 The War on Drugs 🚓

In prisons, a chilling investigation into the rise of paper laced with synthetic drugs & the large number of overdoses
https://www.nytimes.com/2026/03/21/world/deadly-drugs-paper.html
“In the summer of 2024, Mr. Wilks’s team found a single sheet with 10 different concoctions sprayed onto it — a mix of opioids, depressants, cannabinoids and stimulants all jumbled together on the same page, like a Rosetta Stone of synthetic drugs.”

The DEA placed the benzodiazepine bromazolam into Schedule I
https://filtermag.org/dea-temporary-scheduling-bromazolam/

Before Duterte’s Drug War in the Philippines, 2 of his predecessors ran anti-drug campaigns & foreshadowed his horrors to come
Antecedents to Rodrigo Duterte’s Drug War: The Anti-Drug Campaigns of Joseph Estrada (2000) and Gloria Macapagal Arroyo (2003)
https://www.jstage.jst.go.jp/article/seas/advpub/0/advpub_26007/_pdf

On drug transit states, on how drug corridors erode sovereignty by criminal infiltration, but also strengthen state centrality by securitization
Drug Routes as Strategic Corridors: The Geopolitics of Transit States
https://www.researchgate.net/publication/402325335_Drug_Routes_as_Strategic_Corridors_The_Geopolitics_of_Transit_States

In Honduras, an analysis of narcotrafficking & the effects on the licit & illicit economies
Narcotrafficking Across a Nation: The Juxtaposition of NGOs Work and Illicit Activities Embedding into the Licit Economy in Rural Honduras
https://jied.lse.ac.uk/articles/10.31389/jied.301

On the cocaine pipeline from Latin America to Europe
https://insightcrime.org/news/italian-broker-evolution-global-drug-trade/

In Nigeria, on their War on Drugs & their low conversion rate of arrests into convictions
Beyond Arrests and Seizures: Sustaining Nigeria’s War Against Drug Abuse and Trafficking Through Legislative Action
https://ir.nilds.gov.ng/handle/123456789/3471

For adult-use cannabis supply & distribution channels, interviews of French consumers, dealers & police found trust to be a crucial element
Means of Recreational Cannabis Supply and Distribution Channels: Perceptions of Consumers, Consumers/Sellers, and Law Enforcement—A Grounded Theory Approach
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2644545

In the Canary Islands, a high-speed chase led to a man arrested with 230 kg of hashish
https://cannabislaw.report/tenerife-driver-crashes-into-police-car-before-being-caught-with-230kg-of-hashish/

🛡️ Harm Reduction News 🛡️

In Canada, Alberta to close two supervised consumption sites
https://drugdatadecoded.ca/breaking-alberta-government-to-announce-calgary-and-lethbridge-supervised-consumption-site-closures/

Harm Reduction Research

For Canadian supervised consumption sites, a survey of people who use drugs & healthcare providers found that overall, they thought positively of client access & safety but had mixed attitudes towards community benefits & healthcare resource utilization
Perceived impacts of Supervised Consumption Sites (SCS) on key service aspects and settings: Reports from Canadian National Questionnaire on Overdose Monitoring (CNQOM)
https://www.sciencedirect.com/science/article/pii/S095539592600068X

In Canadian First Nations peoples, the initiation of safer opioid supply programs increased 5x between 2019 & 2023
Safer opioid supply initiation among First Nations Peoples in Ontario, Canada, 2019 to 2023
https://www.sciencedirect.com/science/article/pii/S0955395926000952

In US harm reduction, a state-level analysis found that the factors most influencing adoption of harm reduction strategies were “decreases in conservative citizen ideology, increases in the severity of the overdose crisis, and increases in states’ economic resources”
Laboratories of Harm Reduction and Treatment: Determinants of States’ Policy Adoptions to Address the Opioid Epidemic
https://read.dukeupress.edu/jhppl/article/doi/10.1215/03616878-12513804/408536/Laboratories-of-Harm-Reduction-and-Treatment

On harm reduction vending machines, a statement from the Association for Multidisciplinary Education and Research in Substance Use and Addiction supported their broader use
In Support of Harm Reduction Supply Distribution Via Vending Machines: Position Statement of AMERSA, Inc.
https://journals.sagepub.com/doi/abs/10.1177/29767342261421746

For overdose response hotlines & apps, a commentary on the limited data so far & the priorities for moving forward
Policy recommendations for overdose response hotlines and applications as a harm reduction tool: A commentary
https://link.springer.com/article/10.17269/s41997-026-01180-3

In Viennese people using a drug checking service, a survey found that they said it promoted safer use behavior as well as risk awareness & management
Perceived harm reduction impact of a drug checking service in Vienna: A qualitative study among current and prospective service users
https://www.sciencedirect.com/science/article/pii/S0955395926000897

In New York City people who use methamphetamine, an analysis of a health department harm reduction program
The reach, effectiveness, implementation, and maintenance of a New York City harm reduction program enrolling priority populations who use meth, 2017–2022
https://www.sciencedirect.com/science/article/abs/pii/S0376871626001158

🍄 Psychoactives, Psychedelics & Plant Medicines 🍄

For the Santo Daime church in Brazil, more allegations of sexual abuse against top leadership
https://www.ecstaticintegration.org/p/more-allegations-of-abuse-in-santo

For a US lawsuit against an ayahuasca church, a federal judge said the federal government must cover their legal fees of over $2M
https://www.law360.com/cannabis/articles/2455950

A new book on the legendary con of Carlos Castaneda: ‘American Trickster: The Hidden Lives of Carlos Castaneda’ (hattip to Alexander Zaitchik)
https://orbooks.com/catalog/american-trickster/

For cacao, a history of Indigenous use & the potential for interpersonal effects
Potential Interpersonal Applications of Cacao: A Review and Call for Further Research
https://www.researchgate.net/publication/402964077_Potential_Interpersonal_Applications_of_Cacao_A_Review_and_Call_for_Further_Research

Psychedelics & MDMA

For psychedelics versus antidepressants for depression, a meta-analysis found no significant difference
Psychedelic Therapy vs Antidepressants for the Treatment of Depression Under Equal Unblinding Conditions: A Systematic Review and Meta-Analysis
https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2846479

When using psilocybin to treat depression, therapeutic alliance was only weakly correlated with clinical benefit
The role of therapeutic alliance in psilocybin treatment for treatment-resistant depression: A post hoc path analysis
https://www.sciencedirect.com/science/article/abs/pii/S0165032726005136

For the effects of psilocybin on brain functional connectivity, a review of 20 fMRI studies
Psilocybin effects on brain functional connectivity: a systematic review of fMRI studies
https://link.springer.com/article/10.1007/s44192-026-00384-w

Ketamine

In people given IV ketamine, the levels of glutamate (the brain’s most common excitatory neurotransmitter) in their nucleus accumbens (a reward center & regulator of feeding, stress & motivation) were associated with anxious ego dissolution & reductions in vigilance
Ketamine-induced changes in accumbal glutamate and their association with altered states of consciousness
https://www.sciencedirect.com/science/article/pii/S0361923026001280

In monkeys, on the brain wave effects of ketamine & links to antidepressant activity
Comparative EEG analysis of the effects of ketamine enantiomers and metabolites in rhesus macaques
https://journals.physiology.org/doi/pdf/10.1152/jn.00203.2025

In a mouse model of depression, the antidepressant effects of ketamine were prolonged by blocking the kappa-opioid receptor
Kappa-Opioid Receptor Antagonism Prolongs the Antidepressant Effects of Ketamine in Adult Mice with Depression-like Behavior Induced by Adolescent Chronic Unpredictable Stress
https://www.mdpi.com/1422-0067/27/6/2815

🍃 The Plant & its Products 🍃

🌱 Growing 🌱

For scalable cannabis micropropagation, development of a protocol & workflow
Toward scalable micropropagation of Cannabis sativa (chemotype III): Protocol optimization and preliminary evaluation of cannabinoid stability
https://www.sciencedirect.com/science/article/pii/S0926669026004279

For hemp cultivars grown in Missouri, on their variability in yield & lifecycle
Performance of industrial hemp cultivars across U.S. Midwestern environments: evidence from multi-location trials in Missouri
https://www.proquest.com/openview/721779c0cd2a7d91f056bda810dc6a68/1

In a water irrigation study in the Mediterranean, on the best strategies for watering hemp
Integrating Hydraulic Properties into Irrigation Management of Industrial Hemp (Cannabis sativa L., ‘Felina 32’) Under Mediterranean Conditions
https://www.mdpi.com/2073-4395/16/6/649

For infection by the fungus Fusarium oxysporum, an analysis of effects across different cannabis genotypes
Evidence for a wide host range of Fusarium oxysporum isolates originating from Cannabis sativa L. (cannabis) plants and responses of cannabis genotypes to pathogen infection
https://www.tandfonline.com/doi/pdf/10.1080/07060661.2026.2632742

For fungus & pests on cannabis plants, on the efficacy of a fennel oil nanoemulsion & yeast lysate as well as increased cannabinoid levels from microbial inoculants
Natural elicitors and beneficial microbes as sustainable tools for disease management and phytocannabinoid enhancement in Cannabis sativa
https://www.sciencedirect.com/science/article/pii/S092666902600453X

For the root bacteria of hemp, how it is shaped by cultivar type & spider mite levels
Cultivar Identity and Spider Mite Herbivory Shape Rhizosphere Bacteria in Hemp (Cannabis sativa L.)
https://www.mdpi.com/2073-4395/16/6/651

For hemp grain, on using near-infrared spectroscopy to predict protein levels for help in breeding
Near infrared spectroscopy predicts crude protein concentration in hemp grain
https://acsess.onlinelibrary.wiley.com/doi/pdf/10.1002/agg2.70328

For trichome biology, a genetic analysis of cannabis, tomatoes & hops (the only other plant in the family Cannabaceae)
Insights into glandular trichome biology from analysis of organ-specific gene expression programmes in cannabis, hop and tomato
https://pmc.ncbi.nlm.nih.gov/articles/PMC12999219/

⚙️ Extracting, Analyzing & Formulating ⚙️

On distinguishing THC-rich cannabis from CBD-rich hemp, on using a dimer (joined unit) of CBDH+ & CBD to distinguish them via a direct analysis in real time–high-resolution mass spectrometry (DART-HRMS) method
Investigating the Protonated Cannabinoid Dimer Detected in the Forensic Analysis of Cannabis by DART-MS: A Combined Mass Spectrometry and Computational Study
https://pubs.acs.org/doi/full/10.1021/jasms.5c00433

For quantifying cannabinoid levels, on a HPLC-DAD method
HPLC-DAD METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTIFICATION OF CBD, CBDA, Δ9-THC AND Δ9-THCA IN CANNABIS-BASED PRODUCTS
https://www.sciencedirect.com/science/article/abs/pii/S0379073826001179

In oils, on identifying THC analogs using gas chromatography-mass spectrometry (GC-MS) & liquid chromatography-photodiode array-mass spectrometry (LC-PDA-MS)
Identification of Tetrahydrocannabinol (THC) Analogs, Including Methyl Ether Derivatives of THC and Hexahydrocannabiphorol, THC Methyl Carbonate and Its Synthetic by-Product, in Commercially Available Oil Products
https://pubmed.ncbi.nlm.nih.gov/41850764/

For the forensic analysis of drugs, a novel chemometric protocol integrating near-infrared (NIR) spectroscopy developed by the Catalan police
A Novel Chemometric Local Approach for Qualitative and Quantitative Analysis of Cocaine, MDMA, and THC-Related Products: Method Application within the Mossos d’Esquadra (Catalan Regional Police)
https://pubs.acs.org/doi/abs/10.1021/acs.analchem.5c07967

For CBD stability & solubility, a comparison of MCT oil versus a powder-based hydroxypropyl-β-cyclodextrin (HP-β-CD) encapsulation
Matrix-dependent degradation kinetics and impurity fingerprinting of cannabidiol (CBD) in polymeric and lipid preservation systems
https://www.sciencedirect.com/science/article/abs/pii/S0731708526001329

🍞 Food & Nutrition 🍞

For hemp seeds, a review of their nutritional benefits
Hemp Seeds: Exploring Their Potential in Promoting Human Health
https://openurl.ebsco.com/EPDB%3Agcd%3A14%3A38397054/detailv2

For hemp seeds, on the effect of their density on their yield of oil & protein
Physical and Chemical Properties of Density-Graded Industrial Hemp Seeds, Extracted Oil, and Protein in Defatted Meal
https://aocs.onlinelibrary.wiley.com/doi/abs/10.1002/aocs.70079

For hemp seed hull powder, an analysis of its components & positive gut health effects from eating it
Hemp seed hull powder: A sustainable source of bioavailable micronutrients and phytochemicals with inhibitory activity against α-amylase and α-glucosidase
https://www.sciencedirect.com/science/article/pii/S2212429226004633

In laying hens, feeding them hemp flower extract did not adversely affect production performance or egg quality & modestly enhanced albumen & yolk proportions
Effects of Hemp Inflorescences Ethanol Extraction Byproduct on Production Performance, Egg Characteristics, Economic Return and Fecal Nitrogen in Laying Hens
https://www.ijvets.com/pdf-files/25-327.pdf

🏗️ Industrial Uses & Fiber 🏗️

For hemp grown on heavy metal-contaminated soil, the flowers grew the usual amounts of CBD & THC & exhibited the lowest accumulation of heavy metals
Hemp flowers cultivated on a soil contaminated with cadmium, lead and zinc exhibit valorization potential
https://www.tandfonline.com/doi/full/10.1080/15226514.2026.2643786

For cannabis that removed heavy metal from the soil, on the potential of transforming it into usable biochar
Cannabis sativa L. Phytoremediation of Heavy Metal Soil Contamination, Followed by Biomass Valorization
https://www.mdpi.com/2071-1050/18/6/2926

For making biodiesel from hemp oil, a review of the extraction & process optimization
Biodiesel Production From Industrial Hemp Oil: Advances in Extraction, Transesterification, and Process Optimization
https://link.springer.com/article/10.1007/s12155-026-10989-2

For pulping hemp into paper, a comparison of the soda & nitrate-alkaline methods
Comparative Evaluation of Soda and Nitrate-Alkaline Pulping of Hemp, Flax, and Sisal Post-harvest Biomass
https://pubmed.ncbi.nlm.nih.gov/41860439/

For packaging made from hemp, on the effects of stalk maturity on composition & performance
Optimization of industrial hemp production: Influence of stalk maturity on composition, structure, and processing for sustainable packaging
https://www.sciencedirect.com/science/article/pii/S0926669026004486

For concrete cylinders for construction, on the effects of adding a hemp fiber-reinforced polymer with halloysite nanotube (HNT)
Sustainable Approach for the Confinement of Concrete Cylinders Using Fiber-Reinforced Polymers With Bio-Based Hemp and Halloysite Nano Tubes
https://4spepublications.onlinelibrary.wiley.com/doi/abs/10.1002/pc.71028

For hemp-based composites for building, on the effects of different binding materials
Mechanical, Thermal and Fire Behaviour of Hemp-Based Composites with Different Binders for Sustainable Building Applications
https://commons.yildiz.edu.tr/cgi/viewcontent.cgi

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

🏥 Public Health & Bioassays 🏥

In Australia, the cannabis users mostly reported dual-use of medical & recreational use, with the most common reasons for medical use to be anxiety, pain, PTSD & depression
Self-reported reasons for medical and nonmedical cannabis use in Australia: A cross-sectional analysis of the International Cannabis Policy Study 2023
https://www.sciencedirect.com/science/article/abs/pii/S0376871626001055

In Canadian data, the THC mental health warning label on products was remembered by its intended audience, but did not change their behavior
Chasing the High: Cannabis Mental Health Warning Label Recall is Associated with Greater, Not Lesser, High-Risk Use in a National Canadian Sample
https://osf.io/preprints/socarxiv/znrhe_v1
“Daily users who recalled the THC mental health warning reported greater harm and higher-risk use patterns than those who did not.”

For social determinants of health, frequent stress was associated with higher use of cannabis, alcohol & tobacco, while a recent medical check was associated lower odds of using those substances
Examining the relationship between social determinants of health with daily tobacco use, binge-drinking, and daily cannabis use
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0343677

In healthcare students at a Colombian university, attitudes towards medical cannabis were predominantly favorable & supportive of legalization, but most had low self-perceived knowledge & lacked awareness of legal regulations
Knowledge and attitudes toward medical cannabis among medicine, nursing, and physiotherapy students at a Colombian university: a cross-sectional study with multivariate analysis
https://link.springer.com/article/10.1186/s42238-026-00423-x

🧒 Adolescents & Young Adults 🧒

For emotional regulation in young people, a review of 4 studies found cannabis use associated with greater emotional regulation difficulties
Emotion Regulation and Cannabis Use in Young People: A systematic Review
https://www.frontiersin.org/journals/adolescent-medicine/articles/10.3389/fradm.2026.1766637/abstract

In college students, the heavier cannabis users were less likely to share their (hypothetical) cannabis than lighter users
Increasing cannabis use is associated with increased social discount rates and decreased self-reported social use in college students
https://psycnet.apa.org/record/2027-46524-001

In adolescents with affective instability (intense & fluctuating emotions), they had a higher risk of developing psychosis, with cannabis mediating this risk
Affective Instability and Regular Cannabis Use During Adolescence and Subsequent Risk for Psychosis in Early Adulthood: A Longitudinal Birth Cohort Study
https://www.researchgate.net/publication/402693926_Affective_Instability_and_Regular_Cannabis_Use_During_Adolescence_and_Subsequent_Risk_for_Psychosis_in_Early_Adulthood_A_Longitudinal_Birth_Cohort_Study

In an adolescent rat model of cannabinoid exposure, females had an earlier development of inhibitory interneurons in their prefrontal cortex than males, but in males, this persisted into adulthood, with adults having less disinhibition in their prefrontal cortex
Adolescent cannabinoid exposure delays development of prefrontal cortex perineuronal nets and inhibitory interneurons
https://www.sciencedirect.com/science/article/pii/S0306452226002204
In the highest areas of your brain, one of the most important functions is inhibiting (calming) neural signaling. Too much signaling can lead to things like schizophrenia. In these adolescent mice, exposure to strong cannabinoids led to later problems in the proper inhibition of brain signals in their prefrontal cortex. And as you often see, the males had greater problems from adolescent cannabinoid exposure.

🧠 The Brain & Neurological Disorders 🧠

In a mouse model of CDKL5 Deficiency Disorder (a severe neurodevelopmental disorder), enhancing their levels of the endocannabinoid 2-AG by inhibition of the MAGL enzyme (which breaks down 2-AG) reduced some behaviors, modestly improved memory & activated neuroprotective pathways, but did not produce broad behavioral recovery
Endocannabinoid Enhancement via MAGL Inhibition in CDKL5 Deficiency: Selective Cellular Benefits and Domain-Specific Functional Effects in Adult Cdkl5 KO Mice
https://www.mdpi.com/1422-0067/27/6/2773

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

In people with anxiety, their negative affect decreased when using cannabis & this was moderated by vigorous physical activity
Physical Activity Level Moderates Cannabis-Associated Reductions in Negative Affect in Anxious Individuals
https://www.sciencedirect.com/science/article/abs/pii/S014929182600041X

In people co-using tobacco & cannabis, sequential co-use was associated with greater consumption of both substances
Examining in the moment patterns of tobacco and cannabis co-use prior to a tobacco quit attempt
https://www.sciencedirect.com/science/article/abs/pii/S0306460326000882

In this case report of someone with alcohol & cannabis use disorder, relationally organized motivation (in this case, taking care of his widowed mother) caused a reduction in drinking & cannabis use
Relationally anchored motivation in alcohol and cannabis use disorder: a clinical case analysis
https://www.tandfonline.com/doi/abs/10.1080/14659891.2026.2647912

In a mouse model of addiction, a synthetic cannabinoid caused increased levels in the hippocampus (a memory center of the brain) of tryptophan, kynurenine & kynurenic acid (which downregulated levels of the CB1 receptor)
The role of the kynurenine pathway in conditioned place aversion induced by synthetic cannabinoid CP-55940
https://link.springer.com/article/10.1186/s12993-026-00327-z

🦴 Pain, Musculoskeletal, Inflammation & Surgeries 🦴

For PEA in skeletal muscle repair from downhill running, this thesis project found that PEA was associated with an early reduction in muscle pain perception, but not muscle function
A Translational Investigation into Palmitoylethanolamide in Skeletal Muscle Repair
https://researchonline.ljmu.ac.uk/id/eprint/28221/

For hemp flower & leaf extracts, an analysis of their antioxidant activities
Antioxidant Capacity of Hemp (Cannabis sativa L.) Leaves and Inflorescences
https://www.mdpi.com/2076-3417/16/6/2957

🍽️ The Guts, Nutrition & the Microbiome 🍽️

In metabolic measurements of healthy adults, activating the cannabinoid receptors did not alter insulin secretion but did modulate insulin sensitivity as well as the levels of the endocannabinoid anandamide
Acute metabolic effects of cannabinoid receptor modulators during sequential hyperglycemic, euglycemic-hyperinsulinemic clamps in healthy individuals
https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00391.2025

🖐️ The Skin & Topicals 🖐️

In a skin tissue model of UV radiation exposure, CBG protected from oxidative changes & lipid breakdown
Cannabigerol Reduces Lipid Peroxidation Influencing Oxidative Stress and Inflammation Signaling Pathways in Melanocytes Exposed to UVA Radiation
https://www.imrpress.com/journal/FBL/31/3/10.31083/FBL47793

🎗️ Cancer & Chemotherapy 🎗️

For CBD against metastasis (the spreading of tumor cells), this review covered the signaling pathways
Cannabidiol (CBD) as an Anti-Metastatic Agent: Evidence-Based Summary of CBD Effects on Metastatic Steps
https://accesson.kr/skmj/assets/pdf/58279/journal-13-1-45.pdf

In triple-negative breast cancer cells, CBC had the greatest anticancer effects & synergized with the terpene beta-caryophyllene
Synergistic Anticancer Activity of Cannabinoids and Terpenes Against Triple-Negative Breast Cancer Resistance
https://www.mdpi.com/1422-0067/27/6/2730

In pancreatic cancer cells, CBG caused apoptosis (programmed cellular suicide) & ferroptosis (a newly discovered type of cell death mediated by iron) via stress to the endoplasmic reticulum (protein processing center)
Cannabigerol Induces Endoplasmic Reticulum Stress-Mediated Apoptosis and Ferroptosis via the IRE1α-XBP1 Axis in Human Pancreatic Cancer Cells
https://www.sciencedirect.com/science/article/pii/S089158492600242X

In glioblastoma cells (the most aggressive brain cancer), activating the CB1 receptor induced pathways of ferroptosis (a newly discovered type of cell death mediated by iron) via increased oxidative stress
The iron fist of nature: Cannabinoid derivatives alter iron homeostasis and activate ferroptotic pathways in glioblastoma cells
https://www.sciencedirect.com/science/article/abs/pii/S0022356526005185

🔬 Biochemical Discoveries & Research Tools 🔬

For the minor cannabinoid cannabioxepane, on a novel synthesis method
Improved Total Synthesis of Cannabioxepane, a Minor Phytocannabinoid from Cannabis sativa L
https://pubs.acs.org/doi/abs/10.1021/acs.orglett.6c00468

On developing a CB2 receptor toggle switch based on the synthetic cannabinoid HU-308
Single-position ligand modifications tune CB2R activity by targeting the toggle switch
https://pubs.rsc.org/en/content/articlehtml/2026/sc/d6sc00062b

Thanks.
- lex

PS: For this week’s pioneer of blues guitar, Memphis Minnie & her 1929 album ‘Queen Of The Blues’. Born in Mississippi (probably - though she claimed New Orleans), Lizzie Douglas was the oldest of 13 children. At 8 years old, she received her first guitar as a Christmas present & by the age of 11, she was playing that & the banjo at parties. At the age of 13, she ran away from home to live on Beale Street, playing on street corners & returning to her family’s farm whenever she ran out of money. In 1916, the Ringling Brothers Circus picked her up & she toured with them for 4 years. When she returned to Beale Street, she found a thriving blue scene where she made her living by playing guitar & doing sex work. In 1929, she was performing with her 2^nd husband Kansas Joe McCoy when a talent scout from Columbia found them playing for quarters on a street corner & took them to New York City to record, where they were given the names Kansas Joe & Memphis Minnie. Her first hit was the song “Bumble Bee”. She recorded with Kansas Joe for the next few years until their divorce in 1935.
As she struck out on her own, she combined that Mississippi Delta mixture of dance rhythms, melodic phrasing & storytelling, helping to shape the style of blues. On stage, she was assertive & confident, establishing herself as a role model for the generations of bad ass female blues artists to come (according to the blues musician Johnny Shines, “Any men fool with her she’d go for them right away. She didn’t take no foolishness off them. Guitar, pocket knife, pistol, anything she get her hand on she’d use it”). And she was well respected by her male peers. In a cutting contest (music battle) with Big Bill Broozny, he remembered her beating him with her songs & winning the prize of a bottle of whiskey & a bottle of gin, later saying she could “pick a guitar and sing as good as any man I’ve ever heard”. By 1941, she had started playing electric guitar & was recording for blues labels around Chicago. She recorded over 200 songs through the early 1950s before musical taste began to change & her health began to decline. When Social Security couldn’t cover her bills, people sent in donations. When she passed away in 1973 at the age of 76, Bonnie Raitt paid for her headstone, the inscription reading, “The hundreds of sides Minnie recorded are the perfect material to teach us about the blues. For the blues are at once general, and particular, speaking for millions, but in a highly singular, individual voice. Listening to Minnie’s songs, we hear her fantasies, her dreams, her desires, but we will hear them as if they were our own”.

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C&P#181: cannabis for cancer, female orgasmic disorder & canine osteoarthritis + lots on psychedelics

Lex Pelger WhiteWhaleCreations — Mon, 23 Mar 2026 10:02:09 GMT

Cannabinoids & The People,
or; Drugs & Drug Wars

🌟 This week 🌟

Cannabis for people with prostate cancer
CBD isolate increased food intake
For canine osteoarthritis, full-spectrum extracts
Cannabis for female orgasmic disorder
Smoking of cannabis exacerbated asthma
Preclinical: cannabis for MS + CBD for TBIs, facial pain & diabetic eyes + cannabis roots for gastric ulcers from drinking
Psychedelics: the magic mushroom of Africa discovered + On the ancestralization of 5-MeO-DMT + IV DMT for depression + psilocybin for OCD
On comparing mystical states between MDMA, psilocybin & cannabis, it’s “mindset over molecule”

(this week’s numbers: ~7.5k words, ~19 minutes reading time, 174 papers)

Hello everyone,
Welcome to the 181^st edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news as well as coverage of other psychoactives, the War on Drugs & harm reduction. Support this work with a paid subscription or by buying me a coffee.

📌 Editor’s note 📌:
Whenever people ask me about cannabis & cancer, I point to Justin Kander who has been gathering the evidence for a long time. And now he has made an educational video sharing the science. Plus, you can also get his free book on the subject at FreeCannabisCancerBook.com (now in it’s 8^th edition!).

🤝 Sponsor 🤝: The Cannabis & Health Research Initiative

Want to help expand the knowledge of medical cannabis use in the real world & get paid 100 bucks to do so?

Follow along on Instagram to keep on learning or sign up for the monthly CHRI email (curated by me) to get just the best of clinical research & new reviews twice a month.

🎥 Lex’s new work 🎤

@CannabinoidsAndThe People vids sponsored by CHRI & the National Cannabis Study:

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Canna-Edu Vids for CV Sciences:

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📚 My Book Vids 📚

(@LexPelgerAndHisBooks on TikTok, YouTube & Instagram)
(No time for new vids. Was a solo-papa week & was reading books to kids instead & showing them the classics of animation.)

And as always, at the bottom is the album of the week: the father of the jazz guitar

🧰 Free resources 🧰

CVResearch.info: the cannabinoid science archive I maintain for CV Sciences

My canna-science journalism

My glossary of cannabinoid terms (& containing the legend for my Neural Ocean metaphor with endocannabinoid whales)

💖 Ways to support this work 💖

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📣 A request to spread the word 📣

This newsletter only spreads by word of mouth, so please forward to friends & colleagues.

🍃 BEST OF CANNABINOID SCIENCE 🍃

(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)

⚕️ Clinical ⚕️

In Canadians receiving medical cannabis, 3 months of use were linked to improvements in pain, anxiety, depression & quality of life
Canadian real-world evidence: observational 24-week outcomes for health care practitioner authorized cannabis
https://www.tandfonline.com/doi/full/10.1080/24740527.2025.2593253

2025: For insomnia, the UK Medical Cannabis Registry found the initiation of cannabis to be associated with improvements to subjective sleep quality, anxiety levels & quality of life
UK Medical Cannabis Registry: A clinical outcomes analysis for insomnia
https://journals.plos.org/mentalhealth/article?id=10.1371/journal.pmen.0000390

In people with prostate cancer, cannabinoid therapy was associated with improved pain control & some indicators of tumor response
Quantitative analysis of Cannabinoid Therapy in Prostate Cancer: Integrating Biomarkers, Imaging and Patient Outcomes
https://karger.com/mca/article-pdf/doi/10.1159/000550792/4517761/000550792.pdf

In the energy intake of healthy adults, ~300 mg of CBD increased the amount of food eaten, decreased ghrelin & caused no changes to other glucose or lipid levels
A single dose of cannabidiol increases ad libitum energy intake in healthy adults but does not affect postprandial glucose or lipid metabolism
https://www.sciencedirect.com/science/article/pii/S0195666326000930

For cannabis use in cancer care, a thesis projects survey found the most common perceived benefits to be for pain, stress/anxiety, sleep, appetite & nausea/vomiting
Understanding Cannabis Use in Cancer Care: Patient Perceptions, Patterns of Use, and Provider Communication Among Patients and Survivors at Roswell Park
https://www.proquest.com/openview/d8c57d9402e3ba8ef121401771893c40/1

In someone with tremors & pain after a stroke, this case report found cannabis oil reduced pain, lessened tremors, enhanced motor function & improved quality of life
Sustained Reduction of Dystonic Tremor and Pain after Cannabis Oil Administration and Physiotherapy in Thalamic Ischemia: A One-Year Case Report
https://www.eurekaselect.com/article/152910

For bipolar disorder, this genome-wide association study found links to pathways related to retrograde endocannabinoid signaling (where endocannabinoids in the brain go backwards & tell the upstream neuron to calm its firing)
Retrograde Endocannabinoid Signaling Shows Robust Enrichment in Bipolar Disorder: Insights from Standardized Pathway Analyses
https://assets-eu.researchsquare.com/files/rs-8937137/v1/c8ca8803-7eb3-44a4-98c2-6d8e34ad16ce.pdf

For canine osteoarthritis, an extract of THC, CBD, CBDA, & THCA showed reductions in scores with no adverse effects
Randomized and Blind Evaluation of the Efficacy of a Full-Spectrum Oral Cannabis sativa Oil Extract, Standardized Based on CBD-A, CBD and THC-A, THC in Canines with Chronic Osteoarthritis
https://www.mdpi.com/2076-2615/16/6/900

📑 Reviews 📑

For cannabis & mental health, this widely covered review found little evidence of cannabis helping for anything
Cannabis and Mental Health: A Review
https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2846007

For mental health & substance use disorders, this review found “some evidence that cannabinoids can reduce symptoms of cannabis use disorder, insomnia, tic or Tourette’s syndrome, and autism spectrum disorder”
The efficacy and safety of cannabinoids for the treatment of mental disorders and substance use disorders: a systematic review and meta-analysis
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(26)00015-5/fulltext

For cannabis use & affective symptoms (emotions), this review found cannabis use did not alleviate affective symptoms but that cannabis abstinence did
Investigating the Relationship Between Cannabis Abstinence and Affective Symptoms: A Systematic Review
https://link.springer.com/article/10.1007/s40429-026-00713-7

For fibromyalgia, a review of 4 papers on cannabis
Evaluation of the use of different forms of medical cannabis in the treatment of fibromyalgia: a systematic review
https://www.sciencedirect.com/science/article/pii/S3050708126000169

For female orgasmic disorder, a review of the potential of cannabis
Cannabis and the Future of Treating Female Orgasmic Disorder/Difficulty
https://link.springer.com/article/10.1007/s11930-026-00417-z

In epilepsy, this review found that CBD improved seizure control
Cannabidiol in Epilepsy: Restoring Locomotion and Seizure Control
https://pubmed.ncbi.nlm.nih.gov/41833036/

In sepsis (a severe overreaction of the immune system), a review on the therapeutic potential of the cannabinoids
CANNABINOIDS IN CLINICAL SEPSIS: A SCOPING REVIEW
https://www.sciencedirect.com/science/article/pii/S1413867026003843

For the gut-brain axis & the central nervous system, a review of the effects of CBD & probiotics
Synergistic Neuroimmune Modulation by Cannabidiol and Probiotics for Therapeutic Advancement in CNS Disorders: A Systematic Review
https://www.benthamdirect.com/content/journals/cnsnddt/10.2174/0118715273411035251111055748

In oral medicine, a review on the potential of cannabis
Cannabis in oral medicine: what should we know? A narrative review
https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1651035

⚠️ Harms ⚠️

For asthma & inhaling cannabis, public health data found a significant rate of asthma exacerbation
Association of Inhaling Marijuana with Asthma Attacks: An Analysis of Nationally Representative Survey Data
https://www.sciencedirect.com/science/article/abs/pii/S0012369226003247

In memory tests of cannabis users, males were more impacted for impaired visuospatial working memory
Same Dose, Different Impact: Acute Cannabis Intoxication Impairs Visuospatial Working Memory in Both Sexes, With Disproportionate Male Vulnerability
https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2026.1785335/abstract

In a Canadian mental health survey, cannabis was associated with a higher prevalence of anxiety, depression & suicidality
Changes in Cross-Sectional Associations Between Cannabis Use and Anxiety, Depression, and Suicidality in a Nationally Representative Sample of Canadians From 2012 to 2022: Évolution des relations transversales entre la consommation de cannabis et la dépression, l’anxiété et les idées suicidaires au sein d’un échantillon représentatif de Canadiens à l’échelle nationale, de 2012 à 2022
https://journals.sagepub.com/doi/10.1177/07067437261420701
As always, the question was if cannabis was causative or if they were treating their symptoms with it. I suspect that it’s the former for some people & the latter for others.

For adults trying to stop using cannabis, a survey found that “practice for change” & “changes in social environment” were associated with sustained cessation
Exploring Recreational Cannabis Use Cessation Intentions among Adults in the United States Using the Multi-Theory Model of Health Behavior Change
https://journals.sagepub.com/doi/abs/10.1177/29767342261417057

For cannabinoid hyperemesis syndrome, a paper framing it as an endocrine-metabolic disorder
Cannabinoid Hyperemesis Syndrome as an Endocrine–Metabolic Disorder
https://europepmc.org/article/ppr/ppr1141701

A case report of an eye hemorrhage 2 hours after cannabis consumption
Premacular Subhyaloid Hemorrhage in a Young Adult After Cannabis Consumption: A Case Report
https://assets.cureus.com/uploads/case_report/pdf/471715/20260316-50419-lyce7k.pdf

🐁 Preclinical 🐁

In mice taking THC, the addition of CBD altered the changes to locomotion & body temperature, with gendered differences
Cannabidiol dose modulates behavioral response to acute and repeated administration of Δ9- Tetrahydrocannabinol by strain and sex
https://www.biorxiv.org/content/biorxiv/early/2026/03/09/2026.03.05.709920.full.pdf

In a mouse model of multiple sclerosis, a cannabis extract reduced hypersensitivity, promoted motor function recovery & caused antidepressant & anxiety-reducing effects via the CB2 receptor
A sesquiterpene-rich essential oil from Cannabis sativa L. attenuates symptoms and neuroinflammation in experimental autoimmune encephalomyelitis model through a CB2-mediated signalling
https://www.sciencedirect.com/science/article/pii/S0944711326003041

In a rat model of severe traumatic brain injury, CBD caused neuroprotective & anti-inflammatory effects
Neuroprotective and anti-inflammatory effects of cannabidiol in rats submitted to severe traumatic brain injury
https://www.sciencedirect.com/science/article/pii/S240584402600215X

In a mouse model of orofacial inflammatory pain, local injection of CBD reduced pro-inflammatory cytokines, oxidative stress markers & neural pain transmission as well as helping anxiety levels, depression symptoms & cognitive performance
Effects and mechanisms of cannabidiol in attenuating orofacial inflammatory pain and ameliorating pain-related affective deficits
https://www.sciencedirect.com/science/article/pii/S0361923026000997

In the eyes of a mouse model of diabetes, CBD protected the retinas & reduced weight gain
Electroretinographical analysis of the effect of cannabidiol (CBD) in eyes of Zucker diabetic fatty rats
https://link.springer.com/article/10.1186/s42238-026-00421-z

In a mouse model of ketamine causing hyperlocomotion, brain injection of CBD blocked the effects via glycine receptors in the ventral tegmental area (a center of dopamine signaling for reward & motivation)
Cannabidiol Mitigates Ketamine-Induced Hyperlocomotion via Allosteric Potentiation of Ventral Tegmental GlyRα1 Signaling
https://www.sciencedirect.com/science/article/abs/pii/S0006322326011078

In a mouse model of gastric ulcers from alcohol, cannabis root extracts reduced gastric injury
Cannabis sativa L. roots extract modulates gastrointestinal motility and ameliorates ethanol-induced gastric ulcers in animal models
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1743428/full

In preclinical models of inflammatory bowel disease, this meta-analysis of 27 studies found cannabinoid significantly reduced disease activity
Efficacy of Exogenous Cannabinoids in Pre-Clinical Models of Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
https://journals.sagepub.com/doi/full/10.1177/25785125261428842

In a mouse model of diabetes, the lignanamides Cannabisin A & B extracted from hemp seed hulls improved fasting glucose & metabolic signaling
Cannabisin A and B from hemp seed hulls improve glucose homeostasis by re-engaging insulin, leptin, and AMPK pathways via selective PTP1B inhibition
https://www.sciencedirect.com/science/article/abs/pii/S0944711326002904

In a tissue model of the blood-brain barrier, CBN partial reversed barrier dysfunction, CBD caused an anti-inflammatory signal & CBG was pro-inflammatory at higher concentrations
Minor cannabinoids have pleiotropic effects on human brain microvascular endothelial activation and barrier function
https://assets-eu.researchsquare.com/files/rs-8982679/v1/5a7ce8fb-07be-4ea0-9018-64e5f7d7802a.pdf

In a tissue model of Barth Syndrome (an X-linked condition of an enlarged heart, weak muscles, recurrent infections & a short stature), CBD restored their growth levels & biomarkers of heart health
Effects of Cannabidiol on TAFAZZIN-Deficient B-Lymphoblastoid Cells
https://pubmed.ncbi.nlm.nih.gov/41823370/

In a tissue study of the major foodborne pathogen Listeria monocytogenes, CBD suppressed virulence mechanisms & protected from infection
Efficacy of Cannabidiol in Reducing Virulence of Listeria monocytogenes
https://www.mdpi.com/1422-0067/27/6/2682

For antibiotic activity against Gram-positive bacteria, on the effects of CBG & CBGA derivatives
Structure–Activity Relationships of Cannabigerol and Cannabigerolic Acid Derivatives as Antibacterial Agents against Gram-Positive Bacteria
https://pubs.acs.org/doi/full/10.1021/acsomega.6c00126

🆕 Novel Studies 🆕

(a grab bag section for cool & new stuff)

In cannabis research, on using AI to analyze the scientific trends
Harnessing machine learning and multivariate analysis to explore global trends in Cannabis sativa research
https://link.springer.com/content/pdf/10.1186/s42238-026-00397-w_reference.pdf

📰 US Headlines & Fav Articles

On US CBD products, the FDA submitted a report on their proposed enforcement policy (though the text is still private)
https://www.marijuanamoment.net/fda-submits-new-cannabis-products-enforcement-policy-for-white-house-review/

On the history of prison music & redemption songs, the Marshall Project is starting a new newsletter focused on the stories of musicians
https://mailchi.mp/themarshallproject/redemption-songs-the-music-of-mass-incarceration-4783480

🌐 International Updates 🌐

In South Africa, a judge declared all cannabis clubs illegal
https://www.cannabiz-africa.com/blog/cannabis-act-controversy-justice-official-says-no-to-private-clubs-ahead-of-reviewing-public-submissions

In the Netherlands, a court forced a credit card processor to continue processing payments from cannabis coffee shops
https://cannabislaw.report/nl-times-dutch-court-stops-payment-service-from-blocking-coffeeshop-card-transactions/

In Portugal, a soccer club fined for the strong smell of cannabis coming from their stands
https://cannabislaw.report/no-longer-war-on-the-terraces-but-weed-on-the-terraces-vinicius-jr-owned-portuguese-1st-division-team-alverca-fined-for-the-strong-smell-of-cannabis-in-stands-during-match/

In a Swiss study on the recreational cannabis access via pharmacies program, problematic cannabis use predicted higher levels of depression & anxiety, but no associations to psychosis symptoms
Bidirectional association of psychopathology and cannabis use: Results from the Swiss study on recreational cannabis access via pharmacies
https://www.sciencedirect.com/science/article/pii/S0165032726004556
And they had no changes in biomarkers for neuroaxonal damage & astroglial injury (respectively, neurofilament light chain (NfL) & glial fibrillary acidic protein (GFAP))
NfL and GFAP quantification and associations with mental health in recreational cannabis users-Results from the Swiss study on recreational cannabis access via pharmacies
https://pubmed.ncbi.nlm.nih.gov/41826780/

In Germany, a small survey found no increased cannabis consumption after legalization
Code for: Change and antecedents of cannabis consumption after the legalization of recreational cannabis in Germany
https://www.psycharchives.org/en/item/83621542-76f4-41b1-a627-3a7b3ab10b7f

In Australia over the last 20 years, public health data found the levels of cannabis use & cannabis use disorder to have been stable
Prevalence, Associations and Comorbidity of Cannabis Use and Cannabis Use Disorders in the Australian National Mental Health Surveys From 2007 to 2020–22
https://pmc.ncbi.nlm.nih.gov/articles/PMC12968346/

In Djibouti’s cannabis industry, a review of women’s participation
A Systematic Review of Gender Dynamics in the Emerging Legal Cannabis Industry of Djibouti, 2000–2003: Leadership, Equity and the African Context
https://parj.africa/ajws_womenlead/article/view/a-systematic-review-of-gender-dynamics-in-the-emerging-legal

⚖️ Business, Laws & Education ⚖️

For cannabis taxes, they drive increased educational spending per pupil
High Hopes, Fungible Dollars: Does Earmarked Marijuana Tax Revenue Actually Increase Education Spending?
https://ape.socialcatalystlab.org/papers/apep_0633/v1/paper.pdf

In Northern California, interviews on the potential of cannabis agritourism
Cannabis Agritourism and Local Pathways Toward Sustainable Development Goals in Northern California
https://onlinelibrary.wiley.com/doi/pdf/10.1002/sd.70907

In Facebook cannabis advertising, food cues were associated with increased shares & comments
Foodie Traps within Facebook Cannabis Promotional Posts: Deploying Multimodal Deep Learning AIs to Monitor Audience Engagement
https://www.sciencedirect.com/science/article/abs/pii/S0376871626001092

🚓 The War on Drugs 🚓

In US cannabis seizures, adult-use cannabis laws were associated with a significant decrease in cannabis seizures
Cannabis legalization and law enforcement drug seizures: a state-level analysis of cannabis policy effects on cannabis seizures in the United States, 2010–2023
https://www.sciencedirect.com/science/article/abs/pii/S0955395926000691

In Uruguay, people living in neighborhoods with drug trafficking organizations were less likely to register for legal cannabis access
Why Remain Illegal? The Deterrent Effect of DTO Control on Legal Cannabis Market Access
https://www.bcu.gub.uy/Estadisticas-e-Indicadores/estudios/Documents/fynn_et-al.pdf

In Nepal, a history of drugs & their drug laws
Drugs in Nepal: History, Law, and the Case for a Balanced Policy
https://www.nepjol.info/index.php/VOH/article/view/87276

On the scholarship of Peter Reuter for reshaping drug policy analysis
On Reuter’s contribution to the drug policy debate
https://www.tandfonline.com/doi/abs/10.1080/17440572.2026.2642310

On autonomous submarines for drug smuggling
https://cannabislaw.report/autonomous-narco-submarines-the-new-technological-frontier-of-organized-crime/

In the UK, a gang dressed up as police to raid rival cannabis farms
https://cannabislaw.report/uk-drugs-gang-dressed-as-coppers-to-raid-cannabis-farms/

In Libya, 3 men were sentenced to life imprisonment & 2 men to 10-year terms for cannabis cultivation
https://cannabislaw.report/libya-five-people-sentenced-to-life-and-10-years-in-prison-for-cannabis-cultivation/

In Sydney, a man charged after a bust with ~1k plants (said to be valued at $3M, making each plant worth $300k(?!))
https://cannabislaw.report/australia-nsw-strike-force-grassy-man-charged-after-more-than-3m-worth-of-cannabis-seized/

In South Australia, a middle-aged woman busted for growing 3 cannabis plants
https://cannabislaw.report/burra-south-australia-major-crime-scene-55-year-old-woman-busted-for-growing-3-cannabis-plants/
And then another woman busted with 4 plants
https://cannabislaw.report/south-australian-police-at-it-again-last-week-it-was-an-arrest-of-someone-with-3-plants-this-week-a-64-year-old-woman-with-4-plants/

🚗 Driving 🚗

In simulated driving performance of regular cannabis smokers, on the effects of potency on various driving measures
Potency-related effects of smoked cannabis on simulated driving performance: a randomized, controlled crossover trial
https://www.nature.com/articles/s41598-026-43045-2_reference.pdf
“Mean speed did not differ across conditions. Maximum speed increased under medium and high potencies versus placebo. SDLP [standard deviation of lateral position] was higher across all Δ9-THC potencies. Both SDLP and RT [reaction time] positively correlated with blood Δ9-THC concentrations.” (p values removed)

In young adult drivers, a survey found the majority reported using cannabis while driving, one-third reported driving after cannabis & alcohol use, often with passengers present
Retrospective Event-Level Patterns of Cannabis-Impaired Driving
https://www.jsad.com/doi/abs/10.15288/jsad.25-00378

For predicting alcohol & cannabis impaired driving in young adults, AI found the top predictive factors for cannabis-impaired driving to be “cannabis use frequency, cannabis-related memory problems, simultaneous alcohol and cannabis use frequency, increased cannabis tolerance, and age of cannabis initiation”
Using machine learning to identify unique predictors of alcohol and cannabis impaired driving
https://pmc.ncbi.nlm.nih.gov/articles/PMC12981337/

In injured drivers, on the gendered differences between their alcohol & cannabis use
Sex differences in cannabis- and alcohol-related motor vehicle collisions in three U.S. states with legalized cannabis: A multicenter observational study
https://www.tandfonline.com/doi/abs/10.1080/15389588.2026.2623006

🛡️ Harm Reduction News 🛡️

In Ontario, outcry over 7 supervised drug consumption sites being forced to close after the provincial government cut their funding
https://www.cbc.ca/news/canada/toronto/ontario-ending-supervised-drug-consumption-funding-9.7130534
https://toronto.citynews.ca/2026/03/13/ford-government-to-end-consumption-site-funding-two-toronto-sites/

For drugs in overdose deaths, the CDC just released its first report in 10 years on the drugs most frequently involved
https://filtermag.org/cdc-specific-drug-overdose-death-data/

Harm Reduction Research

On public health vending machines, an analysis of their efficacy in the US
Extending harm reduction through public health vending machines: Insights from implementation efforts in the United States
https://www.sciencedirect.com/science/article/pii/S2949875926000640

On overdose prevention centers, a media analysis found the majority to be favorable or neutral
News Media Coverage of Overdose Prevention Centers: A Content Analysis
https://assets-eu.researchsquare.com/files/rs-8991788/v1/a7783630-4142-4cfe-a926-db029df12a2d.pdf
“The most frequently cited benefits of OPCs were linkage to wraparound services (94.1%); rapid overdose response (90.8%); and exchange of safer use supplies (82.4%). The top cited negative consequences included stigmatizing arguments counter to evidence such as enabling drug use (51.3%), increased crime (24.4%), and public drug use (22.7%).”

In Australia, the majority supported needle exchange programs, take-home naloxone, drug checking services & a health response to drugs, but not the legalization of anything
Attitudes to Drug Policy in Australia, 2001–2022/23: What Does This Mean for Drug Policy Reform in Australia?
https://pmc.ncbi.nlm.nih.gov/articles/PMC12989179/

🍄 Psychoactives, Psychedelics & Plant Medicines 🍄

In Africa, the closest relative of the magic mushroom discovered: Psilocybe ochraceocentrata
Discovery of the closest free-living relative of the domesticated ‘magic mushroom’ Psilocybe cubensis in Africa
https://royalsocietypublishing.org/rspb/article/293/2066/20252270/480730/Discovery-of-the-closest-free-living-relative-of

For 5-MeO-DMT, on its ancestralization (reframing as an ancient practice when really it was not) & its integration into the modern shaman scene
Fabricated ancestrality: The Sonoran Desert toad, psychedelic globalization, and the ecological politics of 5-MeO-DMT
https://www.sciencedirect.com/science/article/pii/S2950484826000056

For ibogaine, a review of its history from a plant of the Congo to a pharmaceutical product
The long roots of ibogaine: A journey from plant to pharmaceutical
https://akjournals.com/view/journals/2054/aop/article-10.1556-2054.2026.00491/article-10.1556-2054.2026.00491.xml

In West Africa, a report on their synthetic drug markets
Mapping synthetic drug markets in West Africa
https://globalinitiative.net/wp-content/uploads/2026/03/Lucia-Bird-et-al-Mapping-synthetic-drug-markets-in-West-Africa-GI-TOC-March-2026.pdf

For novel psychoactive substances around the world, this meta-analysis of 190 studies found the most frequent to be synthetic cannabinoids, synthetic cathinones & PCP-type substances
Prevalence of Novel Psychoactive Substance (NPS) Use Across Different Geographical Regions of the World: A Systematic Review and Meta-Analysis
https://link.springer.com/article/10.1007/s40429-026-00728-0

Psychedelics & MDMA

In a comparison of mystical experiences between psilocybin MDMA & cannabis, the findings found a “mindset over molecule pattern” where the setting mattered more than the substance
Mindset over molecule: comparing self-transcendent and mystical experiences across recreational psilocybin, MDMA, and cannabis use
https://link.springer.com/article/10.1186/s40359-025-03921-4

For depression, intravenous DMT caused a significant reduction in scores that persisted for up to 3 months
A short-acting psychedelic intervention for major depressive disorder: a phase IIa randomized placebo-controlled trial
https://www.nature.com/articles/s41591-025-04154-z

In people with obsessive-compulsive disorder, psilocybin sessions reduced scores
A randomized clinical trial of repeated doses of psilocybin for the treatment of obsessive–compulsive disorder
https://journals.sagepub.com/doi/abs/10.1177/02698811261424214

In Oregon’s psilocybin program, sessions were associated with improvements in depression, anxiety & well-being
Psilocybin services and mental health outcomes within Oregon’s state-regulated model
https://www.medrxiv.org/content/10.64898/2026.02.18.26346580v1

In people trying to stop smoking tobacco, a combination of psilocybin & cognitive behavioral therapy (CBT) worked better than a nicotine patch with CBT
Psilocybin or Nicotine Patch for Smoking Cessation: A Pilot Randomized Clinical Trial
https://pubmed.ncbi.nlm.nih.gov/41805956/

In people naïve to 5-MeO-DMT, an intranasal formulation caused peak experiences around 15 minutes & a return to baseline by 60 minutes
Mapping the phenomenology of intranasal 5-MeO-DMT in psychedelic-naïve healthy adults
https://www.nature.com/articles/s41598-025-22620-z

For death anxiety, this meta-analysis of psychedelics found a moderate-to-large reduction
Confronting mortality: A meta-analysis and systematic review of psychedelic experiences and death anxiety
https://journals.sagepub.com/doi/pdf/10.1177/02698811261424199

For transgender & gender-expansive psychedelic users, interviews on their healing of racism and/or trans phobia
Transgender and gender-expansive psychedelic users’ concerns about colonization, racism, and medicalization in western psychedelic science
https://www.sciencedirect.com/science/article/pii/S2950484826000044

On Australian public drug alerts, on finding the threshold for MDMA levels (they settled on ≥ 150 mg)
Exploring the Utility and Appropriateness of Dose Thresholds for Issuing of Public Drug Alerts on High-Dose MDMA: A Qualitative Study
https://pmc.ncbi.nlm.nih.gov/articles/PMC12968355/

For postpartum depression, a review of the potential of psychedelic therapy
Psychedelic therapy and postpartum depression: priorities and prospects
https://journals.sagepub.com/doi/pdf/10.1177/20451253251408280

For schizophrenia, a review of the early evidence for psychedelics
Psychedelics for treatment of negative symptoms and depressive symptoms in schizophrenia spectrum disorder: A narrative review
https://www.sciencedirect.com/science/article/pii/S0920996426000800

For depression, a review on combining exercise & psychedelics
The combination of exercise and psychedelics for the treatment of major depressive disorder
https://pubmed.ncbi.nlm.nih.gov/41793582/

On ethical care in psychedelic-assisted therapy
Psychedelics, Harm Reduction, and Ethical Care
https://link.springer.com/article/10.1007/s42843-025-00144-4

For psychedelic clinical trials in adolescents, a review of a potential framework
Toward a framework for psychedelic clinical trials in adolescents
https://pubmed.ncbi.nlm.nih.gov/41808125/

In a mouse model of fatty liver, psilocybin microdosing reduced lipid accumulation & scarring
Exploring the hepatoprotective potential of psilocybin microdosing in steatohepatitis: In vitro and in vivo studies
https://www.sciencedirect.com/science/article/pii/S1590865826001209

In rats taking 5-MeO-DMT, brain scans found gendered differences in the changes in brain connectivity
Beyond the toad’s kiss: Mapping acute 5-MeO-DMT effects on brain connectivity across sex and dose using awake rat neuroimaging
https://www.sciencedirect.com/science/article/pii/S0028390826000596

Ketamine

On rumination, a brain scan study of how ketamine reduced rumination & altered dynamic brain states
Ketamine’s Impact on Rumination-Related Brain Dynamics: Insights From a Randomized Controlled fMRI Trial
https://sciety.org/articles/activity/10.31234/osf.io/q9utr_v1

In people taking ketamine for pain, they also had improvements to their substance misuse as well as their mood
Ketamine Therapy for Chronic Pain Provides Added Benefits for Substance Misuse Therapy
https://sciencevolks.com/medical-research/pdf/SVOA-MR-04-006.pdf

For treatment-resistant depression, a case series on the efficacy of ketamine
A case series of inpatient ketamine infusion for treatment-resistant depression in Taiwan
https://www.sciencedirect.com/science/article/pii/S2773021226000040

In people with cognitive deficits, preclinical evidence found help from ketamine but the only clinical study found cognitive worsening
Ketamine as a Potential Cognitive Enhancer in Neurological Disorders: Evidence from Preclinical and Clinical Studies
https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1786249/abstract

In depression, a neuroimaging review of ketamine’s effect on reward processing
Effect of Ketamine on Reward Processing in Depressive Disorders: A Systematic Review of Neuroimaging Studies
https://pubmed.ncbi.nlm.nih.gov/41804256/

Kratom

For kratom withdrawal, a review of case studies
Clinical presentation and treatment in kratom withdrawal: a narrative review of case studies
https://apcz.umk.pl/JEHS/article/view/69728

In the New England states, a case series of kratom-related deaths
A Retrospective Case Series of Kratom-Related Deaths Reported by Medical Examiners in Select New England States
https://knowledgeconnection.mainehealth.org/cgi/viewcontent.cgi?article=1253&context=jmmc

For death in Florida from mitragynine (an active ingredient in kratom), an analysis of demographics & associated drugs
Case Control study of mitragynine deaths in Florida
https://academic.oup.com/jat/advance-article-abstract/doi/10.1093/jat/bkag017/8524763

Cathinones

For synthetic cathinones, a case series of their involvement in forensic investigations
Case Series Involving the Synthetic Cathinones alpha-PHP, alpha-PiHP, MDPHP, and MDPiHP in Forensic Investigations
https://www.sciencedirect.com/science/article/abs/pii/S0379073826001040

Kava

On kava, a monograph released by the American Herbal Pharmacopoeia
American Herbal Pharmacopoeia Publishes Kava Monograph and Therapeutic Compendium
https://openurl.ebsco.com/EPDB%3Agcd%3A10%3A5763898/detailv2

For cancer & kava, a review of the protective effects
The protective effects of Kava (Piper Methysticum) constituents in cancers: A systematic review
https://rest.mars-prod.its.unimelb.edu.au/server/api/core/bitstreams/c46e94aa-c16a-5031-b046-71fe0ee5e6f0/content

🍃 The Plant & its Products 🍃

For cultivar registration & breeder protection, a proposed framework by friend of the newsletter Dr. Anna Schwabe
A proposed framework for genetic verification and cultivar protection in cannabis
https://www.cell.com/trends/genetics/abstract/S0168-9525(26)00035-1

🌱 Growing 🌱

For sustainable hemp production, a review of key principles & technologies
Protected Cultivation of Medicinal Hemp: A Climate-Resilient Strategy for Sustainable Production
https://www.mdpi.com/2673-9976/51/1/13

For sanitizing medical cannabis flowers, a review comparing the methods
Sanitation of medical cannabis flowers (Cannabis sativa L., flos): comparing current technologies and non-thermal plasma novelties from safety and quality perspectives
https://link.springer.com/article/10.1186/s42238-026-00417-9

In Kentucky hemp & fusarium head blight exposure, on the effects of cover crops
Cover Crop Impacts Fusarium Head Blight Incidence and Mycotoxin Contamination of Cannabis sativa
https://apsjournals.apsnet.org/doi/abs/10.1094/PDIS-02-26-0295-RE

For hemp fiber production, on the effects of nitrogen rates for growth & biomass
Growth and biomass response of industrial hemp (Cannabis sativa L.) cultivars to nitrogen rates for fiber production
https://acsess.onlinelibrary.wiley.com/doi/abs/10.1002/csc2.70258

In the US central Plains states, on the effects of fertilization on yield
Nutrient uptake and partitioning of industrial hemp in the central Plains
https://acsess.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/agj2.70300

In the US central Great Plains states, on the water use of hemp
Water use and productivity of industrial hemp in the US central Great Plains
https://acsess.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/agj2.70331

For fiber hemp of the US Southeast, on how plant population & harvest timing influenced bast yields
Fiber Hemp (Cannabis sativa L.) Production in the Southeast: Discovering How Plant Population and Harvest Timing Influence Bast Yields
https://www.proquest.com/openview/cff608a153dbba5b972f014408d38821/1

In Moroccan cannabis, on the effects of fertilization, temperature, photoperiod & salt stress
Influence of extrinsic factors and salt stress on the in vitro germination and development of Moroccan Cannabis sativa L. varieties as potential medicinal plants
https://horizonepublishing.com/index.php/PST/article/view/11067

In Moroccan cannabis, an analysis of its components, antioxidant activity & antimicrobial activities across different tissue types
Total polyphenol contents, total flavonoid contents, LC–MS analysis, antioxidant, and antimicrobial activities of Moroccan Cannabis sativa L. (Beldia): A comparative study of resin, leaf, and seed extracts and chemometric approach
https://link.springer.com/article/10.1007/s11694-025-03970-8

On analyzing the constituents of Yemeni cannabis
Phytoconstituents determination of cannabis sativa plant extracts
https://www.openabstract.org/abstract/1685/phytoconstituents-determination-of-cannabis-sativa-plant-extracts

For Nigerian cannabis, on creating a chemical profile using a Fourier transform infrared spectroscopy (FTIR) and gas chromatography–mass spectrometry (GC–MS) analysis
ATR-FTIR and GC–MS chemical profiling of Cannabis sativa L. cultivated in Ondo state, Nigeria
https://www.sciencedirect.com/science/article/abs/pii/S0026265X26008994

For hemp stress resistance, a genetic analysis of the Betv gene family
Identification and Expression Analysis of the Betv1 Gene Family in Industrial Hemp
https://link.springer.com/article/10.1007/s12042-026-09464-1

For counting & analyzing hemp seeds, on comparing hand counting versus automated methods
Hemp seed counting and morphometric analysis method comparison
https://acsess.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ppj2.70069
“When accessions were grouped by origin, East Asian accessions were found to have the largest seed size, and US feral accessions had the smallest seed size.”

For cannabis seed detection & classification, on using AI
AI-Powered Cannabis Seed Detection and Classification: A Machine Learning Approach for Precision Agriculture
https://www.researchsquare.com/article/rs-8566248/v1

For classifying cannabis seeds, on using AI
A Comparison of Convolutional Neural Networks using Transfer Learning for Cannabis Seed Classification
https://ceur-ws.org/Vol-4179/short3.pdf

⚙️ Extracting, Analyzing & Formulating ⚙️

For commercial CBD oils, a secret buyer survey found over- & under-labeling
Not what it seems: analytical validation and label accuracy of commercial CBD oils using HPTLC
https://link.springer.com/article/10.1186/s42238-026-00419-7

On differentiating cannabinoid isomers using copper salts & electrospray ionization with a liquid chromatography-mass spectrometry method
Differentiation of cannabinoid isomers via Cu-mediated molecular ion formation and electrospray ionization-tandem mass spectrometry
https://pubmed.ncbi.nlm.nih.gov/41796083/

On creating CBD-microspheres for chronic pain
Development of Cannabidiol-Loaded PLGA Microspheres for Long-Acting Injectable Delivery: Evaluation of Poly(2-ethyl-2-oxazoline) as an Alternative to Poly(ethylene glycol)
https://www.mdpi.com/1999-4923/18/3/336

On nasal delivery of CBD, on the pharmacokinetics of starch-based CBD-loaded nanoparticles in rats
Pharmacokinetic Modeling of the “Nose-to-Brain” Pathway as Demonstrated by Intranasal Administration of Cannabidiol-Loaded Nanoparticles
https://www.mdpi.com/1424-8247/19/3/456

🍞 Food & Nutrition 🍞

In soybean protein-based meat analogues, on improved their sensory characteristics with pea & hemp seed protein hydrolysates
Incorporation of pea and hemp seed protein hydrolysates into soybean protein-based meat analogues for enhanced bioactive and instrumental sensory attributes
https://www.sciencedirect.com/science/article/pii/S2666833526000869

For producing albumin & globulin from hemp protein isolate, comparing ultrafiltration-diafiltration & isoelectric precipitation
Comparison of ultrafiltration-diafiltration and isoelectric precipitation for producing albumin and globulin fractions from hemp (Cannabis sativa L.)
https://www.sciencedirect.com/science/article/pii/S0963996926006277

In broiler chickens, cannabis seeds improve their lipid metabolism & the fatty acid profile of the meat with no adverse effects on growth
Dietary Inclusion of Cannabis sativa Seeds at Graded Levels Modulates Growth Performance, Blood Biochemistry, and Breast Muscle Fatty Acid Composition in Broilers
https://cdnsciencepub.com/doi/abs/10.1139/cjas-2025-0111

🏗️ Industrial Uses & Fiber 🏗️

For phytoremediation, a review of hemp removing heavy metals & forever chemicals
Current Knowledge on Phytoremediation Potential of Industrial Hemp (Cannabis sativa L.) for PFAS and Heavy Metal Contaminated Soils
https://onlinelibrary.wiley.com/doi/pdf/10.1002/rem.70059

For archival storage, paper made from hemp, flax & straw fibers “exhibited sufficient stability and structural integrity”
ASSESSMENT OF RAW PAPERS FROM NON-WOOD FIBRES FOR STORAGE AND PACKAGING OF ARCHIVAL MATERIALS AND CULTURAL HERITAGE OBJECTS THROUGH A MULTI-DISCIPLINARY DIAGNOSTIC METHODOLOGY
https://www.cellulosechemtechnol.ro/firstonline.php

On creating biochar from industrial hemp for protecting antibiotics from degradation
Preparation of industrial hemp stalk charcoal material supported tetranitro cobalt phthalocyanine and iodine-doped bismuth oxide catalyst: enhanced visible-light response and efficient antibiotics degradation
https://www.sciencedirect.com/science/article/abs/pii/S1387700326003655

In hemp pomace (aka hemp cake, a byproduct of oil extraction from seeds), a characterization of the biopolymers & lipids
NMR characterisation of biopolymers and lipids from hemp pomace treated with Thermomyces lanuginosus
https://www.nature.com/articles/s41598-026-41682-1

For 3D-printing biocomposites, hemp retained structural integrity better than flax
Printability versus Durability in 3D-printed biocomposites: unraveling the distinct roles of flax and hemp fibers in PLA-based filaments
https://www.sciencedirect.com/science/article/pii/S2238785426006113

On creating a polymer composite reinforcer glass & hemp fibers
Dynamic mechanical and thermogravimetric analysis of glass/hemp reinforced hybrid polymer composites modified with Graphene and MXene fillers
https://link.springer.com/content/pdf/10.1186/s40712-026-00429-6_reference.pdf

On creating pressure-sensitive hemp fabric coated with multi-walled carbon nanotubes
MWCNT-coated hemp fabric as a wide-range flexible piezoresistive pressure sensor for human motion monitoring and gesture recognition
https://link.springer.com/article/10.1007/s10853-026-12354-2

For hemp fabrics, on the effect of adding a waterborne polyurethane
Synthesis of multifunctional surface-treatment coatings for hemp fabric: Incorporating flame retardancy, hydrophobicity, antibacterial activity, UV resistance, and enhanced mechanical strength
https://www.sciencedirect.com/science/article/abs/pii/S092777572600823X

On creating hemp fibers doped with boron for flame & water resistance
Development of Sustainable Biocomposite Materials Using Boron-Doped Hemp Fabrics
https://link.springer.com/article/10.1007/s12649-026-03547-6

For wear-resistant fibers, on reinforcing hemp & bamboo fibers with micro-crystalline cellulose
Optimizing abrasive wear in sustainable MCC reinforced hemp bamboo epoxy composites for tribological applications
https://www.nature.com/articles/s41598-026-43505-9_reference.pdf

For insulation, an evaluation of composite materials made from hemp, flax & miscanthus shives
Unlocking the potential of bio-Based composites: durability and sustainability of hemp, flax, and miscanthus with low-carbon binders
https://www.sciencedirect.com/science/article/pii/S259012302601128X

On improving lime-hemp composites with biopolymers to decrease water absorption
The combined effect of gum arabic and casein on selected parameters of lime-metakaolin paste and hemp concrete for use as wall material
https://www.sciencedirect.com/science/article/abs/pii/S2352710226006455

In Perlite concrete, on incorporating hemp shives & recycled plastic waste
Hemp shives vs. plastic waste vs. polypropylene fibers in perlite concrete: An experimental comparative study of mechanical performance
https://www.sciencedirect.com/science/article/abs/pii/S095006182600824X

For construction, on creating raw earth/hemp composites with low hemp shiv content
Impact of hemp shiv contents on hygrothermal and compressive properties of raw earth-based sustainable building materials
https://link.springer.com/article/10.1007/s41779-026-01367-4

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

On hemp extracellular vesicles, a review of their therapeutic potential
Hemp-Derived Extracellular Vesicles: A Novel Frontier in Nanomedicine and Therapeutics
https://link.springer.com/article/10.1007/s40259-026-00766-0

On the therapeutic use of cannabis a review of the components, the evidence & the gaps
Insights Into Cannabis and Cannabinoids: Chemical Properties, Legal Perspectives, and Therapeutic Applications
https://onlinelibrary.wiley.com/doi/abs/10.1002/cbdv.202503030

🏥 Public Health & Bioassays 🏥

For pesticides in cannabis, a commentary on how regulations are based on detection & not human health
Pesticides in Cannabis: The Need for Evidence to Inform Policy and Protect Patients
https://www.sciencedirect.com/science/article/abs/pii/S0149291826000378

On novel cannabis ingestion methods, a review of the rise of high-potency concentrates, new inhalation techniques & delta-8 THC
Emergence of New Variants of Cannabis Use: A Systematic Review
https://www.gpub.org/article-details.php

In Massachusetts, on their trends of cannabis use from the Cannabis Control Commission
Cannabis Use Trends in Massachusetts: Findings from the International Cannabis Policy Study, 2019–2023
https://masscannabiscontrol.com/wp-content/uploads/2026/03/Cannabis-Use-Trends-in-Massachusetts-Findings-from-the-International-Cannabis-Policy-Study-2019-2023.pdf

In US public health data, there is a small increase in the tri-use of cannabis, alcohol & tobacco
Trends and Correlates of Past-Month Cannabis, Alcohol, and Tobacco Tri-Use and Intensive Tri-Use: Findings from the Behavioral Risk Factor Surveillance System, 2016–2023
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2632185

In cannabis urine screens at the University of Colorado health system, the positivity rate has plateaued since 2015
Trends in cannabis urine drug screen testing in Colorado’s largest health system: a retrospective cohort study
https://link.springer.com/content/pdf/10.1186/s42238-026-00418-8_reference.pdf

In a northern Israel hospital, attitudes towards cannabis differed significantly by religious affiliation
Cannabis, Religion, and Trust in the Medical Profession: A Cross-Religious Study of Patients’ Attitudes Toward Medical and Recreational Use in Northern Israel
https://pubmed.ncbi.nlm.nih.gov/41833069/
“Christian participants reported the most favorable views toward both medical and recreational cannabis, followed by Jewish respondents, while Muslim and Druze participants expressed more conservative attitudes. Contrary to prior literature, higher trust in the medical profession was associated with more negative cannabis attitudes overall.”

In US cannabis consumers, a survey found that their state’s legal status did not alter their harm or benefit rating
Cannabis use within the United States: Prevalence of cannabis use by state legal status and perceptions of benefit and harm
https://www.sciencedirect.com/science/article/pii/S2772724626000247

For people in supportive housing, the heavy co-users of tobacco & cannabis had less favorable attitudes towards tobacco-free policies & cannabis-free policies
Attitudes toward tobacco-free and cannabis-free policies among residents in permanent supportive housing who use tobacco, cannabis, and other substances
https://www.sciencedirect.com/science/article/pii/S2352853226000222

For extracting cannabis use data from electronic health records, on using a large language model
Extracting patient reported cannabis use and reasons for use from electronic health records: a benchmarking study of large language models
https://www.medrxiv.org/content/10.64898/2026.03.06.26347824v1.full.pdf

For nursing students, a review of their knowledge & attitudes towards cannabis
Nursing Students’ Attitudes and Knowledge of Medical and Recreational Cannabis Use: An Integrative Review
https://journals.lww.com/jan/abstract/9900/nursing_students__attitudes_and_knowledge_of.5.aspx

For cannabinoid urine testing, on using magnetic nanoparticles
Magnetic nanoparticles anchored with zeolites: An alternative material for dispersive magnetic solid-phase extraction for cannabinoids from urine samples
https://www.sciencedirect.com/science/article/pii/S1570023226001182

🧒 Adolescents & Young Adults 🧒

In adolescents, public health data found legalization was not associated with a significant change in cannabis use disorder rates
Nonmedical cannabis legalization and adolescent inpatient cannabis use disorder, 2008–2020: A quasi-experimental analysis
https://www.sciencedirect.com/science/article/abs/pii/S0955395926000745

In college students, more restrictive state cannabis policies were linked to lower odds of cannabis use while more restrictive alcohol policies were linked to higher cannabis use
Associations Between State Cannabis and Alcohol Policy Restrictiveness and College Students’ Cannabis Use, Binge Drinking and Co-Use
https://www.tandfonline.com/doi/full/10.1080/10826084.2026.2641696

In college students, frequent cannabis use was associated with depressive symptoms
Relations between depression and cannabis use among college students in evolving state cannabis policy environments
https://www.sciencedirect.com/science/article/abs/pii/S0376871626001080

In young adults, bipolar disorder risk was associated with cannabis interference in daily life, but not frequency of use or difficulty stopping cannabis
The highs and lows: Cannabis use and positive valence bipolar mood and emotion processes in emerging adults
https://www.sciencedirect.com/science/article/abs/pii/S016503272600491X

In young Canadian cannabis consumers, there were few gendered differences in the prevalence of cannabis use outcomes, but boys had more negative life experiences & the girls had poorer mental health
Gender Differences in Correlates of Cannabis Consumers Among Youth: Results From the 2023 Canadian Health Survey on Children and Youth
https://www.sciencedirect.com/science/article/pii/S1054139X25008110

In young adult females who regularly use cannabis, recent cannabis consequences were associated with a decreased likelihood of subsequent use, except among heavy users
Cannabis Use Problems Moderate Daily Associations between Cannabis Consequences and Subsequent Use
https://www.jsad.com/doi/abs/10.15288/jsad.25-00441

In adolescents of the Pacific Northwest, a survey found that greater exposure to cannabis retail outlets may increase cannabis-related risks & use
A Decade After Legalization: Cannabis Risk Factors Associated with Community Retail Cannabis Exposure among Adolescents in the Pacific Northwest
https://www.sciencedirect.com/science/article/abs/pii/S0749379726000759

In UK schools, an analysis of confiscated vapes found synthetic cannabinoids to be dominant
Illicit substances in school-confiscated vapes: Lessons from a laboratory-driven public health pilot
https://www.sciencedirect.com/science/article/pii/S2666535226000492

For teen cannabis & alcohol use, those with parental disapproval that was neutral or conflicting were more likely to report past-year use
Association Between Perceived Parent Attitudes and Teen Cannabis and Alcohol Use
https://www.sciencedirect.com/science/article/abs/pii/S1054139X26000339

On creating a scale for college students on cannabis & compensatory eating behaviors
Development and Evaluation of the Psychometric Properties of the Modified College Eating and Cannabis Behaviors Scale (CECBS)
https://link.springer.com/article/10.1007/s11469-026-01646-y

🧠 The Brain & Neurological Disorders 🧠

In a mouse model of stroke, the neuroprotection caused by activating CB1 receptors was dependent upon their presence in the neurons producing glutamate (the brain’s most common excitatory neurotransmitter)
Glutamatergic cannabinoid receptor 1 confers neuroprotection against ischemic stroke by suppressing excitotoxicity and anoxic depolarization
https://www.sciencedirect.com/science/article/abs/pii/S0028390826000997

In a roundworm model of Alzheimer’s disease, CBD encapsulated within a zirconium-based metal-organic framework delayed the onset of amyloid-induced paralysis & demonstrated superior neuroprotective potency compared to free CBD
Oral Administration of Cannabidiol via Zirconium-Based Metal-Organic Frameworks: In Vivo Neuroprotective Effects in a C. elegans Alzheimer’s Model
https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15000800/v1

For a CBD lipid nanocarrier, a thesis project on targeting the central nervous system
Active targeting to the central nervous system through the covalent functionalization with cannabidiol of lipid nanocarriers obtained by low-energy methods
https://docta.ucm.es/entities/publication/a5ffb83c-7fb4-4d6b-9221-d401328339cb

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

For cannabis & sleep, a diary & sleep lab study found that cannabis expectancies were associated with overestimated total sleep time & time to sleep
Cannabis Expectancies for Sleep Modulate Discrepancies Between Subjective and Objective Sleep Outcomes: A Pilot Study
https://www.tandfonline.com/doi/abs/10.1080/02791072.2026.2644855

In a stress test of cannabis users, larger skin conductance & heart rate reactivity predicted greater reduction in motivation to change cannabis use
Elevated Stress Reactivity: A Barrier to Cannabis Use Change Behavior
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2640449

In French heavy cannabis users, on the effects of parental separation/divorce & anxiety
Onset of anxiety and mood disorders in French heavy cannabis users: The impact of parental separation/divorce
https://www.sciencedirect.com/science/article/abs/pii/S0013700626000266

For people trying to quit tobacco, cannabis-co-use had a negative impact on abstinence
Determining the impact of cannabis use on tobacco cessation: Results from a prospective non-randomized tobacco treatment trial
https://onlinelibrary.wiley.com/doi/pdf/10.1111/add.70382

For the link between cannabis use & schizophrenia, a review on the utility of preclinical animal models
Which Came First? Utility of Preclinical Models in Cracking the Chicken-or-Egg Relationship between Cannabis Use and Schizophrenia
https://link.springer.com/article/10.1007/s40429-026-00714-6

On creating a mouse model of cannabis use disorder using the synthetic cannabinoid WIN 55,212–2
A Male Mouse Model of WIN 55,212–2 Self-Administration to Study Cannabinoid Addiction
https://bio-protocol.org/en/bpdetail?id=5652&type=0

In stressed mice with overexpression of the CB1 receptor in the hippocampus (a memory center of the brain), they had less weight gain & symptoms of stress
Selective overexpression of hippocampal CB1R alleviates chronic stress-induced neurogenesis impairment and behavior disorder in rats
https://www.sciopen.com/local/article_pdf/10.16016/j.2097-0927.202511032.pdf

🦴 Pain, Musculoskeletal, Inflammation & Surgeries 🦴

In brain scans of people with chronic pain, cannabis use was associated with changes to functional connectivity
The Role of Pain Frequency in the Divergent Associations Between Cannabis Use and Default Mode Network Connectivity
https://www.medrxiv.org/content/medrxiv/early/2026/03/11/2026.03.10.26348038.full.pdf

In people who had wrist surgery, the cannabis users required less opioid painkillers to manage post-operative pain
Opioid Usage in the PACU Following Operative Distal Radius Fracture Repairs in Marijuana Users
https://pubmed.ncbi.nlm.nih.gov/41811263/

In people who had nerve transfer surgery, the cannabis users had no significant differences
Impact of Marijuana Usage on Nerve Transfer Outcomes: A Retrospective Cohort Study
https://www.ovid.com/jnls/neurosurgery/abstract/10.1227/neu.0000000000003964_523~523impact-of-marijuana-usage-on-nerve-transfer-outcomes-a

In trauma patients, a meta-analysis of 30 studies found heterogeneity on their prevalence of cannabis use
Prevalence of cannabis use among trauma patients presenting to the emergency department: A systematic review and meta-analysis
https://www.tandfonline.com/doi/abs/10.1080/15389588.2026.2623013

In a rat model of frostbite-induced chronic pain, activating both the CB1 & CB2 receptor reduced pain via neuroimmune, intracellular homeostasis & oxidative stress pathways
Peripheral cannabinoid receptor activation attenuates frostbite-induced chronic pain via modulation of TRP channels, neuroinflammation, and autophagy
https://www.sciencedirect.com/science/article/abs/pii/S0891584926001565

🍽️ The Guts, Nutrition & the Microbiome 🍽️

In a mouse model of GI motility (movement of food), those without CB1 receptors lost significantly more body weight during antibiotic treatment & had faster gut transit but slower colonic motility
Role of CB1 receptors in the gastrointestinal tract after microbiota depletion and natural recolonization
https://assets-eu.researchsquare.com/files/rs-8854797/v1_covered_d35fbf69-6b2a-4717-b81a-a5095c6b9c37.pdf

💧 The Genitourinary System 💧

In a female mouse model of spinal cord injury with the secondary complication of lower urinary tract dysfunction, a CBD-derived molecule reduced bladder weight, improved urodynamics, suppressed spinal cord neuroinflammation & promoted re-establishment of bladder-related neural pathways
A novel cannabidiol-derived small molecule ameliorates lower urinary tract dysfunction in mice with spinal cord injury via suppressing neuroinflammation
https://www.sciencedirect.com/science/article/pii/S0024320526001219

In autosomal dominant polycystic kidney disease (the most common genetic cause of renal failure), the kidney tissue had higher transcription levels of the CB1 receptor & significant reductions in the levels of endocannabinoids & key endocannabinoid-metabolizing enzymes
Progressive endocannabinoid system dysregulation in autosomal dominant polycystic kidney disease
https://link.springer.com/article/10.1186/s10020-026-01457-w

🖐️ The Skin & Topicals 🖐️

For wound healing, on creating a hydrogel dressing with CBD & mupirocin (an antibacterial ointment)
pH-Responsive and Self-Adaptive Hydrogel Dressing Based on a TA/PVA Network Co-Loaded with Cannabidiol and Mupirocin for Synergistic Infected Wound Healing
https://www.sciencedirect.com/science/article/abs/pii/S0944711326002795

🎗️ Cancer & Chemotherapy 🎗️

In glioblastomas (the most aggressive brain cancer), CBD preconditioning moved the tumor microenvironment towards an anti-tumor state, improved disease control & potentially lowered relapse risk
Cannabidiol as a Prophylactic Agent Against Glioblastoma Growth: A Preclinical Investigation
https://www.mdpi.com/1422-0067/27/2/757

In a computer analysis of breast cancer, CBD had strong binding affinities to CDK6, BCL2, MMP2 & VEGFR2
Potential of Using Cannabidiol as a Therapeutic Molecule Against Various Cell Signaling Molecules Involved in Breast Cancer Complications: A Bioinformatics Approach
https://pubmed.ncbi.nlm.nih.gov/41830580/

In cancer cells, inhibitors of the MAGL enzyme (which breaks down 2-AG) caused anti-proliferative activity via glucose
Development of Glycoconjugated MAGL Inhibitors with Glucose-Dependent Antiproliferative Activity
https://www.mdpi.com/1422-0067/27/6/2666

In cancer studies, on the importance of serum concentrations for modulating the cytotoxic potency of cannabinoids
Cytotoxicity Potency of Cannabinoids Is by Serum Supplementation: Implications for In Vitro Cancer Studies
https://pubmed.ncbi.nlm.nih.gov/41810908/

💊 Synthetic Cannabinoids & Hemp-Derived Cannabinoids 💊

For the synthetic cannabinoid FUB-144, an analysis of metabolites produced by the liver
In vitro and in vivo metabolism of the synthetic cannabinoid FUB-144: comprehensive phase I and II profiling using UHPLC–HRMS
https://link.springer.com/article/10.1007/s00204-026-04321-2

🔬 Biochemical Discoveries & Research Tools 🔬

For drugs to activate the CB1 receptor, on creating an AI to help with synthesis
Explainable machine learning to identify cannabinoid 1 receptor agonists
https://www.sciencedirect.com/science/article/abs/pii/S037907382600109X

Thanks.
- lex

PS: For this week’s early jazz guitar maestro, the album ‘Presenting Eddie Lang’. Born in Philadelphia, Lang grew up playing the violin & banjo before finally settling on the guitar when he joined the Mound City Blue Blowers. With them in 1924, he recorded one of the first guitar solos of all time on ‘Deep 2nd Street Blues’. Previously, the guitar was not a prominent instrument in jazz bands or dance orchestras, but with his ability to play sophisticated chords as an accompaniment or lovely single-note solos, Lang drew more prestige to the instrument. With his skills much admired, he played with many of the greats of the 1920s, including Bix Beiderbecke, most notably on their song ‘Singin The Blues’ which the Library of Congress placed in the National Recording Registry. He became friends with Bing Crosby during the filming of the movie ‘King of Jazz’, where you can see Lang playing with the Paul Whiteman Orchestra. As Crosby ventured into radio, he insisted on Lang playing accompaniment & sharing his microphone. Eddie Lang’s career was looking bright when he entered the hospital to finally get his tonsils removed after years of problems, but he never woke up from the surgery. He was only 30 years old & jazz lost a shining star that day.
PPS: A rare content warning, but if you’re listening to this at work, beware when anything comes on by Bessie Smith. She didn’t even try to disguise what it was that she was talking about.

This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.
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C&P#180: CBD suppositories for menstrual pain + chronic pain + anxiety & sleep

Lex Pelger WhiteWhaleCreations — Mon, 16 Mar 2026 11:46:42 GMT

Cannabinoids & The People, or; Drugs & Drug Wars

🌟 This week 🌟

For menstrual pain, CBD suppositories!
Chronic pain: cannabinoids lowering opioid usage + full-spectrum extracts more effective that THC isolate in older adults
In anxious people, CBD helps their sleep
Aerobic exercise = more anandamide = more positive effects
In adults with cannabis use disorder: better mental health than people with other substance use disorders. In young people: worse mental health than other SUDs
Cannabis liberalization laws decrease property & violent crime
Again, driving safety in regular cannabis users not associated with their blood or saliva levels of cannabinoids
‘2026 State of the Cannabis Industry Report’: not great
In Congo foragers, the cannabis users had less parasitic worms
Psychedelics: psilocybin for OCD + US mushroom churches
Harm reduction: in Stockholm, 10 years of harm reduction reduced mortality
One Tommy Boy reference

(this week’s numbers: ~6k words, ~16 minutes reading time, 121 papers)

Hello everyone,
Welcome to the 180^th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news as well as coverage of other psychoactives, the War on Drugs & harm reduction. Support this work with a paid subscription or by buying me a coffee. If you purchase one of my canna-graphic novels based on Moby Dick, proceeds go to Americans for Safe Access to support medical cannabis patients.
For producing cannabinoid content, work with my company White Whale Creations: writing, science archives, social media, newsletters & podcasts (especially podcasts).
As always, ask me anything!

📌 Editor’s note 📌:
- Thanks to Eagle-Eye Dr. Janice Makela for pointing out that last week’s meta-analysis of cannabis for orofacial pain was faked. It’s a growing problem that I see talked about constantly in my weekly reading of Nature: papers mills, fake scientists, guest-editor hijacking, hijacked journals, journal snatchers & the sleuths to root them out (if you want the PDFs of any of these articles, let me know). It gives me a constant feeling of unease because with reviewing an average of 150 papers a week, I don’t have time to double-check all of them. There’s a few authors that I’m watching who feel like they must be paying to produce a stream of low-quality hemp studies or preclinical cancer research or such, but there’s not much I can do about it. And even if a paper is obviously written by AI, that could be someone doing this because English isn’t their first language. Nature talks about the potential of AI tools to help combat the rising flood of faked research, but they do so in the dispirited way of someone who knows that there seems to be little chance of holding back the deluge.
- A new study is recruiting participants who have experienced emergent phenomena like altered states of consciousness, mystical experiences, psychedelic states & spontaneous awakenings.

🤝 Sponsor 🤝: The Cannabis & Health Research Initiative

Want to help expand the knowledge of medical cannabis use in the real world & get paid 100 bucks to do so?

Follow along on Instagram to keep on learning or sign up for the monthly CHRI email (curated by me) to get just the best of clinical research & new reviews twice a month.

🎥 Lex’s new work 🎤

@CannabinoidsAndThe People vids sponsored by CHRI & the National Cannabis Study:

(On YouTube & TikTok)

This Week in Cannabis! (Justice Kagan & ayahuasca?!)

Canna-Edu Vids for CV Sciences:

(on YT @CVSciencesInc & on TT @pluscbd)

📚 My Book Vids 📚

(@LexPelgerAndHisBooks on TikTok, YouTube & Instagram)
Nothing this week. Was too sick. Watch the back catalog.

And as always, at the bottom is the album of the week: a cappella jubilee gospel!

🧰 Free resources 🧰

CVResearch.info: the cannabinoid science archive I maintain for CV Sciences
My canna-science journalism
My glossary of cannabinoid terms (& containing the legend for my Neural Ocean metaphor with endocannabinoid whales)

💖 Ways to support this work 💖
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📣 A request to spread the word 📣

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🍃 BEST OF CANNABINOID SCIENCE 🍃

(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)

On cannabis & the vagus nerve in the new ‘Ask A Neuroscientist’ column in Fat Nugs Magazine
https://www.fatnugsmag.com/ask-a-neuroscientist-cannabis-as-vagus-nerve-medicine/
You connect with the author RN Collins on LinkedIn.

⚕️ Clinical ⚕️

For menstrual pain, whole plant CBD suppositories with the terpenes beta-caryophyllene & humulene reduced symptoms, pain & painkiller usage with significant improvements in cramps, focus, mood, headaches & nausea (hats off to Megan Mbengue & the whole team behind this work!)
Whole Plant CBD Suppositories for Dysmenorrhea: A Real-World Outcomes Report
https://www.researchgate.net/profile/Megan-Mbengue/publication/401555816_Whole_Plant_Cannabidiol_Suppositories_for_Dysmenorrhea_A_Real-World_Outcomes_Report/links/69a8a01abff9750ad9c7e1ce/Whole-Plant-Cannabidiol-Suppositories-for-Dysmenorrhea-A-Real-World-Outcomes-Report.pdf

In older people with chronic pain, a comparison of CBD-rich full-spectrum extracts versus dronabinol (pharmaceutical THC isolate) found that while both caused symptom relief, there were greater improvements & less adverse effects from the full-spectrum extracts
CARE – A Retrospective, Dual-Cohort, 24-Week Real-World Study from the German Pain eRegistry on the Effectiveness and Safety of CBDDominant Oral Cannabis Extracts versus THC/ Dronabinol in Older Patients with Chronic Pain
https://www.tandfonline.com/doi/pdf/10.2147/JPR.S551457

On substituting cannabis for opioids in chronic pain, the majority of participants decreased their opioid intake by more than half, with additional improvements to sleep quality & physical function
Assessing the efficacy of medical Cannabis as a substitution therapy for opioids in chronic pain management: A comprehensive investigation
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0045-1815357

In people with anxiety & sleep-related problems, a month of CBD caused majority to have a decrease in anxiety symptoms & two-thirds saw an improvement in their sleep quality
Cannabidiol effects on Anxiety and Insomnia
https://pharmakeftiki.hsmc.gr/pj/article/view/293

In people with HIV, the cannabis users had less global neurocognitive deficits & a more anti-inflammatory immunometabolic-phenotype, including less pro-inflammatory cytokines, more anti-inflammatory upregulation, more mitochondria (powerhouse of the cell) & more BDNF (a key brain growth factor)
Cannabis Use by People with HIV is Associated with an Anti-Inflammatory Immunometabolic Phenotype in Monocyte-Derived Macrophages
https://www.biorxiv.org/content/biorxiv/early/2026/03/06/2026.03.04.709579.full.pdf

For people doing aerobic exercise (but not yoga), they had higher blood levels of anandamide, with increases correlated to changes in positive effects
Contributions of yoga and aerobic exercise to acute changes in state affect, circulating BDNF and eCB concentrations, and memory
https://www.sciencedirect.com/science/article/abs/pii/S0306453026000776

In people with early schizophrenia, they had higher levels of anandamide, 2-AG & oleoylethanolamide (the endocannabinoid of satiation), with anandamide levels inversely correlated to symptoms
Endocannabinoids and polyunsaturated fatty acids in early schizophrenia: Changes under antipsychotics and association with the response to treatment
https://www.sciencedirect.com/science/article/abs/pii/S0952327826000128

📑 Reviews 📑

For pain, a review of cannabis & the endocannabinoid control of pain (good charts)
Beyond the high: Therapeutic insights into Cannabis sativa and endocannabinoid control of pain
https://www.sciencedirect.com/science/article/pii/S2950199726001023

On CBD for anxiety & depression, a review of 8 studies found strong positive effects for anxiety but insufficient data on depression
Effects of Cannabidiol (CBD) on the Treatment of Anxiety and Depression in Adults: A Literature Review
https://www.mdpi.com/2504-3900/137/1/105

For CBD & athletic performance, a review of 23 studies found that it wasn’t an ergogenic aid (enhancing of performance)
Cannabidiol is Not an Ergogenic Aid: A Systematic Review of Human Performance Studies
https://www.researchgate.net/profile/Whitley-Stone-2/publication/401622864_Cannabidiol_is_Not_an_Ergogenic_Aid_A_Systematic_Review_of_Human_Performance_Studies/links/69aae26f1a0d8b29ca7132dc/Cannabidiol-is-Not-an-Ergogenic-Aid-A-Systematic-Review-of-Human-Performance-Studies.pdf

For electroacupuncture, on how the endocannabinoids mediated the help for pain & itching
[Progress on the mechanism of endocannabinoids involved in electroacupuncture for analgesia and itch relief]
https://pubmed.ncbi.nlm.nih.gov/41777131/

In veterinary medicine, on the potential uses of CBD
Cannabidiol in veterinary medicine: Therapeutic potential and quality assurance challenges in therapeutic trend products
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0045-1815107

⚠️ Harms ⚠️

For atrial septal defects (a baby with a hole in its heart), public health data found cannabis legalization linked to higher levels of this birth defect
Impact of Cannabis and Cannabis Legalization on US Atrial Septal Defect Rates
https://www.mdpi.com/2039-4713/16/2/43

For adults with cannabis use disorder versus other substance use disorders, they had a lower risk for schizophrenia, depression & psychotic disorders, but in pediatric patients, they had a higher risk of schizophrenia, depression & anxiety disorders
Association of Cannabis Use Disorder Versus Other Substance Use Disorders With Psychiatric Conditions: A Propensity-Matched Retrospective Cohort Analysis
https://psychiatryonline.org/doi/abs/10.1176/appi.ajp.20250336

In people with cannabinoid hyperemesis syndrome, a survey on their usage & symptom onset
Cannabinoid Hyperemesis Syndrome: A Survey-Based Approach to Understanding Symptoms and Cannabis Use Patterns
https://journals.sagepub.com/doi/full/10.1177/25785125261421434
“Most respondents reported smoking cannabis flower or using vape cartridges, although the use of edibles and concentrates were also described. The overwhelming majority of respondents (96.5%) used cannabis products at least daily, with approximately half (45%) using them six or more times per day around the time they developed CHS symptoms. Most of the respondents (61.9%) sourced cannabis from licensed dispensaries. The duration of cannabis use prior to symptom onset varied widely among participants, with nearly two-thirds (65.4%) reportedly used for more than 3 years before symptom development. During the prodromal (early) phase, symptoms clustered in the morning (63.1%) and the predominant complaints were nausea and stomach pain. Women reported more frequent and prolonged symptoms than men.”

In adults who accidentally ingested cannabis, a review of 84 adult cases found that most involved baked goods or candy
Unintentional ingestion of psychoactive cannabis products among adults: a scoping review
https://www.sciencedirect.com/science/article/abs/pii/S0002934326001440
“Common presenting symptoms included dizziness, dry mouth/mucous membranes, confusion, vision changes, paresthesia, nausea/vomiting, speech difficulties, anxiety, and somnolence. Hypertension, memory impairment, lethargy, incoordination, and tachycardia were frequent. Stroke was often the leading differential, with food poisoning commonly suspected. Most patients recovered within 24 hours, though some reported lingering subjective symptoms (e.g., fatigue, anxiety).”

At a cannabis manufacturer, an analysis of their reported adverse events
Adverse Events Associated with Medical Cannabis Reported within a Centralized Call Center
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1792520/abstract

🐁 Preclinical 🐁

In a mouse model of metabolic dysfunction-associated steatotic liver disease (MASLD, formerly fatty liver disease), CBD or CBG improved glycemic control, reduced liver fats & normalized blood lipid levels
Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration
https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bph.70387

In a mouse model of a broken bone, CBC reduced pain but impaired bone healing
Cannabichromene attenuates fracture pain but impairs bone repair in a murine tibial fracture model
https://www.sciencedirect.com/science/article/pii/S8756328226000761

In a mouse model of non-alcoholic fatty liver disease, the terpene beta-caryophyllene reduced liver injury markers, oxidative stress, inflammation & scarring via the CB2 receptor
β-caryophyllene mitigates oxidative stress, inflammation and fibrosis by activating cannabinoid-2 receptors in murine model of high-fat diet/streptozotocin-induced nonalcoholic fatty liver disease
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0045-1815186

For hemp root extracts, on a comparison of extraction techniques & analysis of their “superior wound healing and anti-inflammatory effects”
Comparative phytochemical characterization and bioactivity evaluation of hemp (Cannabis sativa L.) root extracts using green extraction technologies
https://www.sciencedirect.com/science/article/abs/pii/S0026265X26007538
There is a very, very long human history of using cannabis roots for medical purposes.

For the infectivity of the SARS-CoV-2 virus, full-spectrum extracts had a higher antiviral effect than isolated cannabinoids, with the most effective being delta-8 THCA
Investigation of natural products from medicinal cannabis as SARS-CoV-2 infectivity inhibitors
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0045-1815406

🆕 Novel Studies 🆕

(a grab bag section for cool & new stuff)

2015: In the Aka foragers of Congo, cannabis users had less infection & reinfection by helminthiasis (parasitic worms)
High prevalence of cannabis use among Aka foragers of the Congo Basin and its possible relationship to helminthiasis
https://onlinelibrary.wiley.com/doi/10.1002/ajhb.22740
I found this paper because the lead author, Dr. Casey Roulette, published the new paper below about female drug users around the world. There is little known about cannabis use among forager & hunting communities so this was quite intriguing to see.

For brain scans of THC impairment, applying machine learning to resting-state functional near-infrared spectroscopy (fNIRS) scans significantly outperformed field sobriety tests
Classification of resting-state THC impairment using fNIRS and machine learning
https://www.spiedigitallibrary.org/conference-proceedings-of-spie/PC13867/PC138670D/Classification-of-resting-state-THC-impairment-using-fNIRS-and-machine/10.1117/12.3083453.short
And for identifying THC impairment during alcohol consumption, machine learning models could detect it from fNIRS scans
Toward objective detection of delta-9-tetrahydrocannabinol Impairment during ethanol consumption
https://www.spiedigitallibrary.org/conference-proceedings-of-spie/PC13870/PC138700B/Toward-objective-detection-of-delta-9-tetrahydrocannabinol-Impairment-during-ethanol/10.1117/12.3085056.short

On creating a bone graft derived from cannabis leaf trichomes
A Multifunctional Conductive Physiomimetic Scaffold: Synergy of rGO Coating and Cannabis-derived Nanotopography for Infection-Resistant Bone Repair
https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1766388/abstract

In a model of the epithelial cells (lining of your body cavities), cannabinoids had increased permeability in the presence of terpenes but the cannabinoid acids did not
Matrix and nanoformulation-dependent bioavailability of cannabinoids in the Caco-2 Model
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0045-1815443

At the CB1 receptor, cannabidiphorol (CBDP, a CBD analog with a shorter tail) caused negative allosteric modulation (binding at an alternative site on the receptor & causing other molecules to bind less strongly to the main binding site)
Cannabidiphorol (CBDP) interactions with Cannabinoid Receptor 1 (CB1R) as a strong negative allosteric modulator
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0045-1814858

📰 US Headlines & Fav Articles

For residency requirements for cannabis licenses, the Congressional Research Service found that courts are split on the issue
https://www.congress.gov/crs-product/LSB11399

‘2026 State of the Cannabis Industry Report’ released by Beau Whitney & First Citizens Bank
https://newsroom.firstcitizens.com/2026-02-26-First-Citizens-Bank-Releases-2026-State-of-the-Cannabis-Industry-Report
“Despite the positivity at the individual company level, after more than a decade of steady expansion, the U.S. cannabis industry is expected to record its first year-over-year revenue decline for 2025, driven largely by sustained pricing pressure and widespread oversupply across many regulated markets. Total U.S. cannabis sales in 2025 are estimated at $28.6 - $29.6 billion, down from approximately $30.1 billion in 2024, even as unit volumes remained stable to positive in select states. Industrial hemp represented a notable bright spot in 2025, and the hemp-derived THC beverage market in particular recorded more than $1 billion in sales.”

In cannabis price analysis, the price of illicit cannabis was significantly lower in states with adult-use laws, though in some states it was more expensive & others less expensive than the legal product
High Stakes: How Legal Cannabis Pricing Impacts the Illicit Market
https://www.researchsquare.com/article/rs-8950795/v1
“In Colorado, California, and Michigan, legal cannabis was significantly less expensive than illicit cannabis, while in Massachusetts, Illinois, Maine, and Connecticut, illicit cannabis was significantly less expensive than legal cannabis.”

In Colorado, cannabis prices reach a new low of $608 per pound
https://www.westword.com/news/colorado-dispensary-weed-prices-reach-sad-new-low-40854902/
And in Massachusetts, cannabis prices are plummeting
https://www.bostonglobe.com/2026/03/11/business/marijuana-prices-massachusetts-dispensaries-weed-cannabis/

For the effects of cannabis laws on crime, an analysis across US states found medical cannabis laws reduced property crime while adult-use cannabis laws reduced violent crime
How does Marijuana legislation affect crime? Medical and recreational laws across 50 states
https://www.sciencedirect.com/science/article/abs/pii/S026499932600101X

Epstein was the target of a secret DEA probe for distributing club drugs
https://www.bloomberg.com/news/features/2026-03-06/epstein-investigated-in-dea-probe-for-ketamine-money-laundering
https://www.ecstaticintegration.org/p/epstein-manson-psychopimps

In Oklahoma, a Vietnamese refugee is facing deportation over an expunged cannabis possession arrest from almost 20 years ago
https://cannabislaw.report/oklahoma-father-faces-deportation-tied-to-nearly-20-year-old-marijuana-case/

In Harrisburg, PA (near where I grew up), a drunk man was charged with cruelty to animals for admitting that he regularly gave his parakeet beer & cannabis
https://cannabislaw.report/friday-story-goes-to-cannabis-smoking-parakeet-injured-by-drunk-pa-man/
This region between Philadelphia & Pittsburgh is sometimes referred to as Pennsyltucky.

🌐 International Updates 🌐

In Granada, the cannabis reform law was confirmed by the Gov.-Gen.
https://nowgrenada.com/2026/03/governor-general-assents-to-cannabis-reform-law/
“Grenada has now entered Phase I of its cannabis initiative, which decriminalises cannabis for personal and religious use while maintaining strict safeguards. Adults may possess up to 56 grams of cannabis and up to 15 grams of cannabis resin. Individuals may also cultivate up to four cannabis plants, provided they first register with the Cannabis Secretariat and the Ministry of Agriculture… The legislation also recognises the sacramental use of cannabis by adherents of the Rastafarian faith.”

In Portugal, raids against hemp products stores resulted in the seizure of thousands of euros worth of products that the merchant said are legal under the law
https://cannabislaw.report/media-report-operation-portugal-always-safe-2026-hemp-shop-owners-say-they-are-ruined-and-complain-about-the-lack-of-training-for-law-enforcement-agents/

In Jamaica, community groups of small ganja farmers are now allowed to cultivate up to 10 acres of cannabis for medical purposes
https://jamaica-gleaner.com/article/news/20260306/new-regulations-coming-benefit-small-ganja-farmers

On legalizing cannabis in the Americas, an even-handed look at the effects in Uruguay, the US & Canada
LEGALISING CANNABIS: THE AMERICAS BETWEEN MYTH AND REALITY
https://flore.unifi.it/bitstream/2158/1458835/1/Book_Rossi_Trovato%2004-03-2026.pdf

In Canada, an analysis of cannabis-related harms
BIG PERCENTAGES, SMALL NUMBERS? UNDERSTANDING CANNABIS-RELATED HARMS UNDER CANADA’S CANNABIS ACT
https://flore.unifi.it/retrieve/587c70b4-9ed7-4e9b-a44c-5ad6d899c34a/Book_Rossi_Trovato%2004-03-2026.pdf

In Germany, an analysis of their recent partial legalization
PARTIAL LEGALIZATION OF CANNABIS IN GERMANY – RECENT DEVELOPMENTS AND FURTHER STEPS
https://flore.unifi.it/retrieve/587c70b4-9ed7-4e9b-a44c-5ad6d899c34a/Book_Rossi_Trovato%2004-03-2026.pdf

⚖️ Business, Laws & Education ⚖️

In Maryland, an analysis & strategy towards an equitable cannabis market
Toward an Equitable Legal Marijuana Market in Maryland: Assessing Development Strategies
https://scholarworks.law.ubalt.edu/cgi/viewcontent.cgi?article=2173&context=ublr

In the UK, Bristol Medical School will offer their first medical cannabis teaching placement
https://cannabishealthnews.co.uk/2026/02/18/bristol-medical-school-to-offer-first-teaching-placement-in-cannabis-medicine/

For US party affiliation & attitudes towards cannabis legalization, by 2024 political ideology “lost significance as an explanatory measure”
Political ideology and party affiliation as determinants of attitudes toward legalization of Marijuana in the United States: Implications for policy conversations
https://journals.sagepub.com/doi/full/10.1177/20503245261431086

🚓 The War on Drugs 🚓

At the UN drug commission, Colombian President Gustavo Petro criticized the war on drugs against coca & cannabis
https://europeantimes.news/2026/03/in-vienna-at-unodc-petro-calls-for-a-smarter-drug-strategy/

Trump announced the formation of the Americas Counter Cartel Coalition, an organization of 17 countries “to operationalize hard power to defeat these threats to our security and civilization”
https://www.whitehouse.gov/presidential-actions/2026/03/commitment-to-countering-cartel-criminal-activity/
And he offered them missiles for hitting drug cartels
https://www.channelnewsasia.com/world/trump-latin-america-us-missiles-drug-cartels-5979116

In British Columbia during decriminalization, police continued possession-based enforcement & off-the-record seizures, especially against socially marginalized people who use drugs
Police encounters with people who use drugs during decriminalisation in British Columbia, Canada: a mixed-methods analysis
https://www.tandfonline.com/doi/full/10.1080/10439463.2026.2634112

In Australia, a defense of supply-side drug policing for reducing drug crime-related harm
Dual-Edged Benefits of Drug Policing: A Quarter Century’s Lesson from a Heroin Drought
https://www.journals.uchicago.edu/doi/abs/10.1086/736041

In Rotterdam, cannabis replaced cocaine as the trafficking drug of choice at Europe’s biggest port
https://cannabislaw.report/nl-times-cannabis-replacing-cocaine-in-drug-trafficking-through-rotterdam-port/

In India, the old hashish smuggling route from Nepal to Sri Lanka is once again becoming more active
https://cannabislaw.report/agencies-flag-revival-of-old-nepal-to-sri-lanka-route-for-smuggling-hashish-charas/

A suspected drug smuggling syndicate from South Africa to the Philippines
https://globalnation.inquirer.net/310025/fwd-pnp-eyes-syndicate-in-drug-arrests-of-foreigners-from-south-africa

In Balochistan, Pakistan, the Afghani poppy cultivation ban has led to a surge in the crop here
https://thediplomat.com/2026/02/is-balochistan-the-regions-new-drug-cultivation-and-trafficking-hub/

In Latin America, on the cocaine supply chain
An Alternative Perspective on the Illegal Drug Trade in Latin America (Part II) The Supply Chain behind the Cocaine Industry: Major Trafficking Routes and Distribution Networks
https://d1wqtxts1xzle7.cloudfront.net/130947465/The_Illegal_Drug_Trade_in_Latin_America_Part_II-libre.pdf?1769759898=&response-content-disposition=inline%3B+filename%3DThe_Illegal_Drug_Trade_in_Latin_America.pdf&Expires=1773328253&Signature=KmIz-6w2HO1TotLqEm~cuo3tbeza141dS5tpOYVmkPjZP0pmIFUsIrz2OP~wj3lUR~yJyJ99YSZrXAwP3BhfAXXXCGbTdp31W3fXWF0r0SCoet7uRaVqQBbgjlheGpgnyUr1~D2lhgPSffXJLDCq14qa~C1KzRHxEHhk5pTtZc43xzzqsvAnTI9mVTeaSRFxqzFUT4OB7R-hy7Csbb5MMX4H2lzQ6P-5E6Attc~xHfrL0dBPqoxuOl3R2fLc4PCdyEvrty5pEokaezKigZPr-ssrsXLji0A-3daKKcA1VFM5R8IbLh9UTofjH6lrq8SnmsQghIfwLX~DLS578YU~hQ__&Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA

In Chiang Mai, Thailand, 4 suspected drug couriers killed & 600k speed pills seized
https://www.bangkokpost.com/thailand/general/3210540/four-suspected-couriers-killed-600000-speed-pills-seized-in-chiang-mai

In Indonesia, 6 members of a cargo ship crew are due to be executed for transporting ~2 tons of methamphetamine
https://www.scmp.com/week-asia/people/article/3344830/indonesias-bid-execute-6-cargo-ship-crew-drug-case-sparks-liability-debate

In Singapore, public support for the death penalty in drug trafficking cases rises to 77%
https://www.malaymail.com/news/singapore/2026/03/12/singaporeans-support-for-death-penalty-in-drug-trafficking-cases-rises-to-77pc-says-minister/212329

In Taiwan, two Vietnamese nationals indicted for 2.2 kg of cannabis (said to be worth ~$95k, an eye-popping $1,200 per ounce)
https://cannabislaw.report/taiwan-yunlin-prosecutors-indict-vietnamese-nationals-for-marijuana-smuggling/

🚗 Driving 🚗

In a driving simulator study, regular cannabis users showed no significant impairment after using cannabis the night before & while their average blood levels of THC were above the limit, neither blood or oral fluid cannabinoid levels were correlated with any measure of driving safety
Driving by frequent cannabis users ‘the morning after’ last use of smoked cannabis: an observational driving simulator study
https://pubmed.ncbi.nlm.nih.gov/41776711/

For driving after cannabis use, the prevalence has increased as well as co-use with alcohol, but on the effects of adult-use cannabis laws, the results were inconclusive
Prevalence of cannabis, alcohol, and simultaneous use among drivers in states with and without recreational cannabis laws, 2021–2023
https://www.sciencedirect.com/science/article/abs/pii/S0022437526000411

🛡️ Harm Reduction News 🛡️

On Norway’s peer-led harm reduction house: Huset Bergen
https://drogriporter.hu/en/huset-bergen-peer-led-harm-reduction-norway/

Harm Reduction Research

In Stockholm over 10 years, their harm reduction of medications & needle exchanges lowered mortality
All-cause mortality and overdose deaths among 4192 people who inject drugs in Stockholm: a 10-year register-based cohort study
https://pubmed.ncbi.nlm.nih.gov/41656245/

At a drug checking service, the discovery of an unexpected active drug caused 20% of people to dispose of the drug or to take a smaller dose
Risk reduction behaviours following the detection of unexpected drugs through community drug checking: a cross-sectional study
https://pubmed.ncbi.nlm.nih.gov/41787496/

In Canadian federal prisons, interviews with institutional heads on their perceived risks with prison needle exchange programs
Gatekeeping harm reduction in Canadian Federal Prisons: Perspectives on the threat risk assessment for the prison needle exchange program by prison administrative leadership
https://onlinelibrary.wiley.com/doi/pdf/10.1111/add.70376

For pharmacy staff, a review of the harm reduction services they can provide for people who use drugs
Harm reduction and pharmacy practice: a scoping review of services for people who use drugs provided by pharmacy staff
https://bmjopen.bmj.com/content/16/3/e110929

🍄 Psychoactives, Psychedelics & Plant Medicines 🍄

In the Toronto psychedelic mushroom shop scene, there’s been a turf war of violence
https://doubleblindmag.com/the-psychedelic-turf-wars-have-officially-begun/

A new Leary biography focusing on the occult aspects: ‘The Occult Timothy Leary: The Tarot, Magical States, and Post-Terrestrial Evolution’
https://lennyflatley.substack.com/p/new-book-alert-the-occult-timothy

The Psychoactive Research

For drug use by females, an ethnographic analysis across 171 societies found “women’s drug use is consistently less frequent and more culturally regulated than men’s”
Female Drug Use in the Ethnographic Record: A Cross-Cultural Analysis of Presence, Variation, and Cultural Context
https://www.mdpi.com/2813-1851/5/1/5

Psychedelics & MDMA

An analysis of US mushroom churches
Neoshamanism: Mushroom Churches in the United States
https://kimberlymelgoza.com/wp-content/uploads/2026/02/kimberly_melgoza_-_final_joaa_paper.pdf

For people with obsessive-compulsive disorder, psilocybin reduced symptoms for weeks to months
A Randomized Controlled Trial of Psilocybin for the Treatment of Obsessive-Compulsive Disorder
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/year/2026/docId/43620

For LSD, brain scans of how it alters brain dynamics & self-related processing
LSD Relaxes Structural Constraints on Brain Dynamics and Default Mode Decoupling Tracks Ego Dissolution
https://www.biorxiv.org/content/biorxiv/early/2026/03/05/2026.03.02.709138.full.pdf

In hallucinogen persisting perception disorder (the visuals from psychedelics not stopping), a case report of someone with cartoonish imagery for 2 years
Distorted Cartoonish Images in the Environment: A Unique Visual Phenomenon in Hallucinogen Persisting Perception Disorder
https://psychiatryonline.org/doi/full/10.1176/appi.ajp-rj.2026.210302

For psychoactive toads, a review of analyses of 5-MeO-DMT & bufotenin
We Licked the Toads so You Don’t Have to: A Comprehensive Analysis of the Chemical Syntheses of the Classical Psychedelics Bufotenin(e) and 5-Methoxy-N,N-Dimethyltryptamine
https://pubmed.ncbi.nlm.nih.gov/41765690/

In psychedelics for PTSD, a review of efficacy & risks
Efficacy and risks of psychedelics in treatment of posttraumatic stress disorder: A systematic review
https://academic.oup.com/ajhp/advance-article-abstract/doi/10.1093/ajhp/zxag062/8507027

Ketamine

On ketamine for depression, a case series where the majority of patients reported 50+% improvements
Intravenous ketamine infusion for major depressive disorder: A Case Series Analysis
https://journals.lww.com/aips/fulltext/9900/intravenous_ketamine_infusion_for_major_depressive.171.aspx

In people with chronic neuropathic pain, a survey found ketamine decreased pain intensity & increased functionality
PAINscape—Exploring patient experiences with ketamine for chronic neuropathic pain: A qualitative study
https://www.tandfonline.com/doi/pdf/10.1080/24740527.2026.2615473

For people with oral mucositis (inflamed mouth & gut tissue, often from chemotherapy), a ketamine mouthwash reduced pain
A Multicenter Randomized Controlled Trial on the Safety and Efficacy of Ketamine Mouthwash for Chemotherapy-Induced Oral Mucositis in Pediatric Patients
https://openurl.ebsco.com/EPDB%3Agcd%3A2%3A38301730/detailv2

In a brain tissue model of ketamine for depression, the mechanism may be via the AMPA receptors
The dynamics of AMPA receptors underlies the efficacy of ketamine in treatment resistant patients with depression
https://www.nature.com/articles/s41380-026-03510-w

🍃 The Plant & its Products 🍃

For hemp essential oil, a characterization of its components, antimicrobial effects & sensory profile
New insights into hemp essential oils: Chemical, antimicrobial, and sensory profiling of underexplored genotypes
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0045-1815251

🌱 Growing 🌱

In the cannabis of northern Morocco, on how the environment altered cannabinoid & terpene production
Environmental determinants of cannabinoid, terpene and safety profiles in Cannabis sativa L. cultivation in Northern Morocco
https://www.sciencedirect.com/science/article/pii/S0926669026003262

In cannabis plants grown under different levels of zinc, the excess levels were stored in the root & not the flowers, “thereby not imposing health risk to the consumers”
The power of zinc: excess and deficiency of Zn decrease cannabinoids in cannabis without Zn toxicity concerns to consumers
https://pmc.ncbi.nlm.nih.gov/articles/PMC12961903/

For enhancing yield, a novel plant-based biostimulant, Tricostimulant™
A Novel Biostimulant for Enhancing Biomass and Therapeutic Compounds in Cannabis sativa
https://www.mdpi.com/2037-0164/17/3/18
“The biostimulant evaluated in this study, Tricostimulant™, is a botanical extract-based formulation containing Centella asiatica, Echinacea purpurea, Taraxacum officinale, Urtica dioica, and fermented rice extract.”

For hemp pollen, levels were increased by adding the biostimulant 3-chlorosalicylate, the fertilizer Nitron S & honey
How the Pollen Grains of the Varieties of Cannabis sativa L. Respond to Biostimulant of Plant Growth and Development and Habitat Conditions?
https://www.tandfonline.com/doi/pdf/10.1080/15440478.2026.2631142

For inducing a callus from hemp, on optimizing the sources & protocol
Development of callus culture protocol for secondary metabolite production from hemp (Cannabis sativa L.)
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0045-1815348

For hemp flowering & cannabinoid biosynthesis, a genetic analysis found 2400+ genes involved
Flowering stage- and cultivar-specific regulation of cannabinoid biosynthesis in hemp: An integrated transcriptomics and metabolomic analyses
https://www.sciencedirect.com/science/article/pii/S0926669026003754

⚙️ Extracting, Analyzing & Formulating ⚙️

For oral mucosal delivery of the cannabinoids, a review of fabrication techniques
Cannabinoid Oral Mucosal Delivery: Approaches to Formulation, Fabrication, and Permeation Enhancement
https://pubmed.ncbi.nlm.nih.gov/41792583/

On the stability of CBD & THC in cannabis oils, an analysis of the effects of light, temperature, excipients & antioxidant additives
Evaluation of the Stability of Cannabidiol and delta-9-tetrahydrocannabinol in Cannabis-based Oily Product: Effects of Light, Temperature, Excipients and Antioxidant Additives
https://www.brjac.com.br/artigos/brjac-72-2025.pdf

On using extracellular vesicles from hemp for creating nanomedicines
Hemp-Derived Extracellular Vesicles: A Novel Frontier in Nanomedicine and Therapeutics
https://pubmed.ncbi.nlm.nih.gov/41787227/

Encapsulating CBD into micelles for better bioavailability
From Water-Based Cannabidiol Formulations to Porous PEGDMA Platforms: A Material Approach Toward Transdermal Delivery Using Polymeric Micelles
https://pubs.acs.org/doi/abs/10.1021/acsapm.5c04920

On creating a CBD nanocarrier
Design of experiments to develop and optimise the nanocarriers: the case of vesicles loaded with cannabidiol and coated with chitosan
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0045-1815449

On improving the bioavailability of cannabinoids with glycosylation
Biotechnological routes to efficient glycosylation of cannabinoids
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0045-1814829

On creating complexes of Cannabisin A & Cannabisin B with zein
Non-covalent complexation of zein with hemp seed Cannabisins A and Cannabisins B: Molecular mechanisms, structural characterization and enhanced functional properties
https://www.sciencedirect.com/science/article/abs/pii/S0141813026011360

🍞 Food & Nutrition 🍞

In hemp seeds, flours & oils, an analysis of their cannabinoid levels (with some exceeding EU guidelines)
Comprehensive profiling of phytocannabinoids and phenolic compounds in hemp seeds, flours, and oil
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0045-1815294

In bread made from hemp seeds & hemp bakery products, on the level of cannabinoids & their stability during baking
Hemp containing breads: Cannabinoid content, profiles, and thermal stability during baking
https://api-depositonce.tu-berlin.de/server/api/core/bitstreams/9fde4573-6876-4e45-a4e4-8076d20395ed/content

For gelatin hydrogels, adding hemp protein enhanced water-holding capacity, gel strength & antioxidant activity
Rheological and Bioactive Profile of Gelatin—Hemp Protein Hydrogels
https://www.mdpi.com/1420-3049/31/5/885

In oleogels (edible fats), hempseed oil stabilized them
Hemp seed oil oleogels stabilized by a soy protein isolate-sodium alginate complex: Structural characterization and kinetics model
https://www.sciencedirect.com/science/article/abs/pii/S0308814626008836

🏗️ Industrial Uses & Fiber 🏗️

For brake pads, on reinforcing polymer composites with hemp fiber
Design and Development of Hemp Fiber Reinforced Polymer Composites for Advanced Brake Pad Applications
https://onlinelibrary.wiley.com/doi/abs/10.1002/masy.70233

For treating wastewater, hemp shives covered in ZnO nanolayers had high degradation efficiencies against tested pollutants
Hemp shives conformally-coated by ALD ZnO for a sustainable application in wastewater remediation
https://www.sciencedirect.com/science/article/pii/S1010603026001322

For supercapacitors, on improving performance with hemp sawdust waste
Hemp sawdust‐derived N/S/P‐doped high surface area activated carbons for supercapacitors: Correlation between structural properties and performance
https://aiche.onlinelibrary.wiley.com/doi/abs/10.1002/ep.70314

For a hemp/nettle polyester composite, an evaluation of its structural integrity
Bending and vibration analysis of hemp/nettle polyester composite to evaluate the structural integrity
https://pubs.aip.org/aip/acp/article/3365/1/030005/3382504/Bending-and-vibration-analysis-of-hemp-nettle

On creating hemp fiber with higher CBD levels for transferring into the skin
Hanffaser mit erhöhtem CBD-Gehalt [Hemp fiber with increased CBD content]
https://openurl.ebsco.com/EPDB%3Agcd%3A5%3A22815909/detailv2

For denim fabrics, hemp yarn improved performance & feel
Thermophysiological and tactile comfort properties of denim fabrics with hemp blended single and dual-core yarns
https://www.emerald.com/rjta/article-abstract/doi/10.1108/RJTA-11-2025-0260/1345092/Thermophysiological-and-tactile-comfort-properties

For degumming industrial hemp fiber, on a green refined process for yarn production
Green degumming of industrial hemp fibers: Property enhancement and application in hemp/cotton blended yarns
https://www.sciencedirect.com/science/article/pii/S092666902600364X

For the acoustic performance of hemp fiber, a phosphorus-based flame-retarding treatment caused a small reduction in sound absorption performance
Impact of a phosphorus-based fireproof treatment on the acoustic performances of bulk hemp fibers
https://www.sciencedirect.com/science/article/pii/S0003682X26000678

For lightweight geopolymer mortars, hemp fibers enhanced mechanical performance
Hemp Fiber and Expanded Perlite-Incorporated Lightweight Inorganic Polymer Mortars: Mechanical, Thermal Insulation, High-Temperature Resistance, Microstructural Characteristics, and Life Cycle Assessment
https://www.mdpi.com/2073-4360/18/5/653

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

🏥 Public Health & Bioassays 🏥

In cannabis-related deaths in New Zealand, the main causes were from road crashes & multi-drug poisoning
Safety Implications of Cannabis Use: Rates, Characteristics, and Circumstances of Cannabis-Related Deaths in New Zealand, 2012–2016
https://www.mdpi.com/2313-576X/12/2/32

In US healthcare majors, those with clinical experience had less support for medical cannabis use
Clinical Experience and Student Support for Medical Cannabis Use: A Secondary Analysis
https://www.researchgate.net/publication/400697161_Clinical_Experience_and_Student_Support_for_Medical_Cannabis_Use_A_Secondary_Analysis

For cannabis-related attentional bias, on using a novel tool for eye-tracking
Examining the Reliability and Utility of MouseView.js as a Method to Measure Attentional Bias for Cannabis Use
https://www.researchgate.net/publication/401129938_Examining_the_Reliability_and_Utility_of_MouseViewjs_as_a_Method_to_Measure_Attentional_Bias_for_Cannabis_Use

For electronic health records, on using AI to document cannabis usage
Cannabis Use Documentation within the Electronic Health Record: A Use Case for Natural Language Processing Methods
https://www.medrxiv.org/content/10.64898/2026.02.27.26347207v1

For analyzing endocannabinoid levels in saliva & blood, a minimally invasive LC–MS/MS method
A Minimally Invasive LC–MS/MS Approach for Assessing Endocannabinoids in Saliva and Capillary Blood Microsamples
https://www.mdpi.com/2079-6374/16/3/147

On quantifying the CBD blood levels with an LC-MS method
Development and validation of an LC-MS analytical method for the quantification of cannabinoids in blood plasma of medicinal CBD users
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0045-1815301

🧒 Adolescents & Young Adults 🧒

For buying drugs from social media & messaging apps, a survey found that while young people were more likely to use Snapchat & that those using high security apps like Telegram or Signal were more likely to buy a wider range of drugs
What app? Demographic and drug use predictors of buying drugs via different social media and messaging apps
https://www.sciencedirect.com/science/article/pii/S0955395926000721

In young adult cannabis users, they had higher biomarkers for artery hardening
Inhaled combusted cannabis use is associated with proatherogenic changes in young people: A cross-sectional study
https://www.medrxiv.org/content/10.64898/2026.03.04.26347657v1.full.pdf

In young people, the cannabis users tended to have a later sexual debut age
The association between sexual debut age and marijuana consumption in U.S. residents
https://www.tandfonline.com/doi/full/10.1080/14659891.2026.2639406

In young adults, discrimination was associated with increased cannabis usage
Intersecting marginalized identities, multiple discrimination, depressive symptoms, and cannabis use among U.S. young adults, 2021–2024
https://www.tandfonline.com/doi/full/10.1080/15332640.2026.2630725

In adolescents with nonsuicidal self-injury versus suicide attempts, those who had attempted suicide had higher blood levels of PEA
Differentiating Nonsuicidal Self‐Injury (NSSI) From Suicide Attempts in Adolescents: A Pilot Study
https://onlinelibrary.wiley.com/doi/pdf/10.1002/mdb2.70030

🧠 The Brain & Neurological Disorders 🧠

In a cellular model of Parkinson’s disease, CBD prevented cell death
Chemical analysis of the polyphenolic fraction in industrial Hemp vr. Kompolti infusions: metal analysis, antioxidant capacity, and cannabidiol in vitro neuroprotective qualities
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0045-1815414

In a cellular model of multiple sclerosis, activating a heteromer of the CB1 receptor & GPR55 receptor (which may one day be known as CB3) increased resilience of the oligodendrocytes (creators of the myelin sheath, which degrades in MS)
Neuroprotective Role of Cannabinoid CB1 and GPR55 Receptors in a Cell Model of Multiple Sclerosis
https://pmc.ncbi.nlm.nih.gov/articles/PMC12956920/

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

In the standard test for cannabis use disorder, the 2 most important factors were use intensity & awareness of problematic use
A two-factor structure for cannabis use disorder identification test and its associations with demographic factors and cannabis use motives
https://www.frontierspartnerships.org/journals/advances-in-drug-and-alcohol-research/articles/10.3389/adar.2026.16094/full

In people with first-episode psychosis induced by cannabis, they had greater self-esteem than those with first-episode psychosis not induced by cannabis
Self-Stigma Patterns in Cannabis-Induced Versus Non-Cannabis-Induced First-Episode Psychosis
https://www.tandfonline.com/doi/abs/10.1080/15504263.2026.2638185

For people at high risk for psychosis, a survey found the majority were familiar with CBD & willing to try it
Acceptability of cannabidiol as a treatment for people at clinical high risk for psychosis
https://www.medrxiv.org/content/medrxiv/early/2026/03/06/2026.03.05.26347694.full.pdf

In people being treated for alcohol use disorder, co-use with cannabis lowered the likelihood of treatment completion
Investigating the Effect of Secondary Cannabis Use in Treatment Discontinuation Among Individuals Undergoing Alcohol Use Disorder Treatment
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2632184

In a mouse model of binging alcohol, inhibiting the MAGL enzyme (which breaks down the endocannabinoid 2-AG) lessened ethanol consumption via changes to genetic transcription in the brain, with gendered differences
Dose- and sex-related effects of the MAGL inhibitor MCH11 on binge-like ethanol consumption in mice
https://www.sciencedirect.com/science/article/pii/S0028390826000833

🧬 Reproduction & Hormones 🧬

For conversations around perinatal cannabis use (before & after birth), surveys of providers found that only half are comfortable with the topic
Provider Perspectives of Conversations and Practices Surrounding Perinatal Cannabis Use
https://publications.sciences.ucf.edu/cannabis/index.php/Cannabis/article/view/347

In a mouse model of prenatal cannabinoid exposure, the offspring had decreased brain microvasculature
Application of correlation mapping optical coherence angiography to study the impact of prenatal cannabinoid exposure on fetal brain vasculature
https://www.spiedigitallibrary.org/conference-proceedings-of-spie/13833/1383306/Application-of-correlation-mapping-optical-coherence-angiography-to-study-the/10.1117/12.3081522.short

In a rat model of prenatal THC exposure, they had alterations to their AMPA receptors (mediators of excitatory neurotransmission & synaptic plasticity)
Prenatal Exposure to a Moderate Dose of Δ9-Tetrahydrocannabinol Alters Hippocampal AMPA Receptor Channel Function Without Changing Subunit Expression
https://www.mdpi.com/2673-9488/6/1/18

🦴 Pain, Musculoskeletal, Inflammation & Surgeries 🦴

In adolescents undergoing sedation, heavy users of cannabis had higher sedation requirements
CANNABIS USE AND SEDATION OUTCOMES IN ADOLESCENT PATIENTS UNDERGOING DEEP SEDATION
https://www.ovid.com/jnls/ccmjournal/abstract/10.1097/01.ccm.0001186812.21536.99~1204-cannabis-use-and-sedation-outcomes-in-adolescent

Before sedation, on the creation of a tool for cannabis use screening
CREATING A SHORT PRE-SEDATION CANNABIS USE SCREENING TOOL
https://www.ovid.com/jnls/ccmjournal/abstract/10.1097/01.ccm.0001187056.29545.1e~1265-creating-a-short-pre-sedation-cannabis-use-screening

In a mouse model of migraines, activating their CB1 & CB2 receptors reduced symptoms
Cannabinoid actions on sensitized dural nociceptors in a non-surgical mouse model of migraine-like pain
https://assets-eu.researchsquare.com/files/rs-8714966/v1/09a4e3dc-c788-4fbb-a32d-7986b25cd8ff.pdf

For inflammation, on creating a hybrid of CBD & oleoside (from olives)
Design and synthesis of a cannabidiol-oleoside hybrid molecules targeting lipoxygenases for inflammation management
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0045-1814827

❤️ The Heart & Blood ❤️

In a rat model of the heart effects from male cannabis plants, they had dose-dependent effects on vasoconstriction
Endothelium-dependent and adrenergic involvement in the biphasic vascular effects of a phenolic-rich ethanolic fraction from male Cannabis sativa inflorescences
https://www.sciencedirect.com/science/article/pii/S2468227626001183

🍽️ The Guts, Nutrition & the Microbiome 🍽️

In a mouse model of obesity, they had higher levels of endocannabinoids & blocking their CB1 receptor or the DAGL enzyme (which produces the endocannabinoid 2-AG) reduced food intake
Enhanced 2-arachidonoyl glycerol-dependent CB1 activation contributes to feeding dysregulation in KK-Ay mice
https://pubmed.ncbi.nlm.nih.gov/41775653/

On derivatives of CBN for inhibiting the α-glucosidase enzyme (breaks down starches & sugars into glucose for intestinal absorption)
Cannabinol derivatives, a new series of α-glucosidase inhibitors: synthesis, structure–activity relationship, and kinetic study
https://www.tandfonline.com/doi/abs/10.1080/14786419.2026.2638950

👀 The Eyes 👀

For eye delivery of CBD, on creating a liposome gel
Thermosensitive chitosan-coated liposome-based gel for ocular delivery of cannabidiol: development, characterization, and in vivo evaluation
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0045-1814842

🖐️ The Skin & Topicals 🖐️

In a rat model of burn injury, activating the CB1 & CB2 receptors in the body reduced pain, especially mechanical hypersensitivity via the TRP channels
Activation of peripheral cannabinoid receptors by CB13 attenuates burn injury–induced chronic pain through TRP channel modulation
https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.70350

In a mouse model of muscle loss due to cancer treatment, an analysis of the changes to the endocannabinoid levels in their guts & gut microbiome
Changes in levels of endocannabinoidome mediators in mice with cancer cachexia: links with steatosis and gut microbial dysbiosis
https://www.nature.com/articles/s44276-026-00208-y

In skin cancer cells, CBD caused cytotoxicity via the CB1 receptor
Exploring the Therapeutic Potential of Cannabidiol in Cutaneous Squamous Cell Carcinoma: An Integrated Computational and Experimental Study
https://onlinelibrary.wiley.com/doi/pdf/10.1002/qua.70172

On creating a CBD polymeric film for topical applications
POLYMERIC FILMS FROM HPMC AND a-GOS INCORPORATED WITH CANNABIDIOL FOR TOPICAL USE
https://www.researchgate.net/profile/Isabela-Angeli-De-Lima/publication/401624557_POLYMERIC_FILMS_FROM_HPMC_AND_a-GOS_INCORPORATED_WITH_CANNABIDIOL_FOR_TOPICAL_USE/links/69ab0821bff9750ad9c88681/POLYMERIC-FILMS-FROM-HPMC-AND-a-GOS-INCORPORATED-WITH-CANNABIDIOL-FOR-TOPICAL-USE.pdf

🎗️ Cancer & Chemotherapy 🎗️

In lymphoma, nano-CBD inhibited cellular proliferation
CANNABIDIOL NANOFORMULATIONS INHIBIT CELL PROLIFERATION AND CANCER-STEM CELL MARKER CD133 IN IN VITRO MODELS OF BURKITT LYMPHOMA
https://www.sciencedirect.com/science/article/pii/S2531137926000507

In cancer cells, on the anti-inflammatory effects of CBDA
Exploring the anti-inflammatory potential of CBDA
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0045-1815216

For triple-negative breast cancer, a thesis project on using CBD
Controlled-delivery formulations of cannabidiol to optimize the treatment of triple negative breast cancer
https://docta.ucm.es/entities/publication/357bda81-4bb0-4ff3-9e93-d0697de3f11a

💊 Synthetic Cannabinoids & Hemp-Derived Cannabinoids 💊

For the synthetic cannabinoid cumyl-5F-P7AICA, on how it travels through the body of a pig
Does a carboxamide moiety alter the toxicokinetics of synthetic cannabinoids? A study after pulmonary and intravenous administration of cumyl-5F-P7AICA to pigs
https://pubmed.ncbi.nlm.nih.gov/39630204/

🔬 Biochemical Discoveries & Research Tools 🔬

In a tissue model of studying CB1 receptor activation, on how the different drugs altered signaling by G-receptor proteins & the secondary messenger cAMP
Functional selectivity of cannabinoids at CB1 receptors: Comprehensive analysis of G proteins, β-arrestin and cAMP signalling dynamics in HEK293T cells
https://www.sciencedirect.com/science/article/pii/S0014299926002177

Thanks.
- lex

PS: For this week’s a cappella jubilee gospel, the album ‘The Incredibles Swan Silvertones’ by the Swan Silvertones. Formed in 1938 in West Virginia by the coal miner Claude Jeter, the 6 singers got their name when they began their 15-minute radio show in Knoxville, Tennessee sponsored by the Swan Bakery Company. Able to quit their jobs & sing full-time, they came to national attention over the next decade as they recorded with a few different labels. But then they signed with Vee-Jay & their new arranger Paul Owens made their sound more progressive & in 1956, they began adding instruments. Their greatest hit, the 1959 ‘Oh Mary Don’t You Weep’, inspired Paul Simon to write ‘Bridge Over Troubled Water’. Despite the departure of Jeter in 1965 for the ministry, the group recorded 18 more albums & were eventually inducted into the Vocal Group Hall of Fame.

C&P#179: cannabis for back pain, blistering skin, dementia, Parkinson’s & reducing the runner’s high (?)

Lex Pelger WhiteWhaleCreations — Mon, 09 Mar 2026 14:28:56 GMT

Cannabinoids & The People, or; Drugs & Drug Wars

(buy my canna-graphic novels based on ‘Moby Dick, or; The Whale’ & proceeds go to Americans for Safe Access to support medical cannabis patients)

🌟 This week 🌟

Cannabis for back pain + THC/CBD for the blistering skin condition epidermolysis bullosa
Do cannabis users get less of a runner’s high?
Meta-analyses: cannabinoids for the agitation of dementia & the pain of Parkinson’s
Older adult cannabis users: (moderately) better memory & intelligence scores, with no added dementia risk
Cannabis & memory: on the acute negatives
Reviews: cannabis for the caregivers of older adults, cannabinoids for cancer & CBG for drug-resistant epilepsy
On air quality analysis of secondhand cannabis smoke
In CHS, on the many other negative mental health effects linked to it, including suicidality
On the negatives of the synthetic cannabinoids
Preclinical: cannabinoids increasing oxidative stress? + help for pain, liver disease & METH use disorder
Psychedelics: psilocybin for Lyme disease, but another negative for microdosing
Harm reduction: new book on adolescents & harm reduction around their drug use

(this week’s numbers: ~7.7k words, ~21 minutes reading time, 149 papers)

Hello everyone,
Welcome to the 179^th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news as well as coverage of other psychoactives, the War on Drugs & harm reduction. Support this work with a paid subscription or by buying me a coffee.

A paid subscription on Substack

For producing cannabinoid content, work with my company White Whale Creations: writing, science archives, social media, newsletters & podcasts (especially podcasts).
As always, ask me anything!

📌 Editor’s note 📌:
I was in High Times this week talking about the ill effects of cannabis on sperm. Thanks to Hernán Panessi for the questions & for making me organize all my science on the topic. And for any other science writers one of the researchable topic, just reach out to me. Happy to get this info out in the world

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🎥 Lex’s new work 🎤

@CannabinoidsAndThe People vids sponsored by CHRI & the National Cannabis Study:

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This Week in Cannabis! (early March)
Safety Testing in Licit vs Illicit Cannabis

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For International Women’s Day, 10 children’s books about female scientists & artists
The Kalevala! (my new obsession with this Finnish epic)

And as always, at the bottom is the album of the week: for International Women’s Day, the archetype of the girl groups

🧰 Free resources 🧰

CVResearch.info: the cannabinoid science archive I maintain for CV Sciences
My canna-science journalism
My glossary of cannabinoid terms (& containing the legend for my Neural Ocean metaphor with endocannabinoid whales)

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📣 A request to spread the word 📣
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🍃 BEST OF CANNABINOID SCIENCE 🍃

(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)

⚕️ Clinical ⚕️

In people with lower back, cannabis caused sustained reductions in pain & disability over 4 years
Long-Term Pain Response to Cannabis Therapy in Chronic Low Back Pain: A Four-Year Prospective Observational Study Evaluating Patient-Reported Outcomes and BioWell Parameters
https://www.preprints.org/frontend/manuscript/72df47a2e705cc36cea1d73672792422/download_pub

In people with epidermolysis bullosa (a rare condition of fragile, blistering skin), sublingual THC/CBD caused 75% of participants to report ≥30% global pain reduction, with the use of painkillers dropping by half
Sublingual tetrahydrocannabinol and cannabidiol to treat pain in epidermolysis bullosa: a randomized, placebo-controlled crossover study
https://academic.oup.com/bjd/advance-article/doi/10.1093/bjd/ljag072/8498796

In people exercising, the cannabis users had lower levels of anandamide at the end of their session as well as a worse mood & a higher probability of feeling pain
Regular Cannabis Use is Associated with a Diminished Anandamide Response to a Standard Exercise Stimulus: A Pilot Study
https://journals.sagepub.com/doi/full/10.1177/25785125261428008
Does this mean less of a runners high for the cannabis users because they’ve been using up the amount of high they have? With the links between the endocannabinoid system & the runners high, this would make some sense.

In older adults, cannabis users performed modestly better on tests of numeric memory & fluid intelligence, with no associated dementia risks
Cannabis use, cognitive function and dementia risk in older adults: observational and genetic analyses
https://mentalhealth.bmj.com/content/29/1/e302290

For the effects of cannabis on memory, this double-blind study found cannabis increased susceptibility to false memories & detrimentally impacted verbal memory, visuospatial memory, event-cued prospective memory, source memory & temporal order memory
Mapping the acute effects of cannabis on multiple memory domains: A randomized, double-blind, placebo-controlled study
https://journals.sagepub.com/doi/abs/10.1177/02698811261416079

But conversely, in people with problematic cannabis use, they had a selective deficit only in complex working memory capacity but no other areas of executive domains
Dissociating the cognitive underpinnings of recreational cannabis use from problematic use
https://www.sciencedirect.com/science/article/pii/S0010440X26000246

In humans with painkilling effects from a placebo, the painkilling was associated with increases in the FAAH enzyme (which breaks down anandamide)
The Endocannabinoid System’s Contribution to Placebo Analgesia
https://www.biorxiv.org/content/biorxiv/early/2026/02/26/2026.02.25.707676.full.pdf

In people with PTSD & cannabis use disorder, cannabis abstinence was associated with significant reductions in PTSD symptoms
The Effects of Extended Cannabis Abstinence in Comorbid Posttraumatic Stress Disorder and Cannabis Use Disorder
https://pubmed.ncbi.nlm.nih.gov/41734366/

For alcohol use disorder, a meta-analysis of 63 studies found preclinical evidence that CBD & CB1 inverse agonists reduce alcohol intake while CB1 agonists (like THC) increase consumption, but human studies showed inconsistent & generally null effects
Modulating the endocannabinoid system in alcohol use disorder: A translational systematic review and meta-analysis of preclinical and human studies
https://www.nature.com/articles/s41380-026-03523-5

For dementia, a meta-analysis of 10 studies found that cannabinoids reduced agitation
Efficacy and Safety of Cannabinoids for Neuropsychiatric Symptoms of Dementia: A Systematic Review with Meta-analysis
https://pubmed.ncbi.nlm.nih.gov/41748849/

In Parkinson’s disease, a meta-analysis of 6 studies found that CBD & THC helped with symptoms, including pain
The Effects of Therapeutic Cannabis and Cannabinoids in Parkinson’s Disease: An Overview of Meta-Analyses
https://www.mdpi.com/2673-9992/43/1/3

For orofacial pain, a meta-analysis of 6 studies found cannabis caused significant pain relief in oral cancer
Cannabis-Based Therapies for Chronic Orofacial Pain: A Systematic Review and Meta-Analysis
https://revistas.ucr.ac.cr/index.php/rOdontos/article/view/3386

In 2 people with Lennox-Gastaut Syndrome (a rare pediatric epilepsy), CBD increased one person’s levels of phenytoin, raising the levels of clobazam & causing seizure freedom, but in the other person, CBD led to phenytoin toxicity with ataxia and falls
Cannabidiol inhibits phenytoin clearance and can result in clinical changes: Two cases
https://www.sciencedirect.com/science/article/abs/pii/S1059131126000543

For insomnia, a comparison of lorazepam versus a traditional Thai cannabis-based multi-herbal formulation found that both significantly improved sleep quality as well as quality of life & stress improvements
Phase II randomized controlled trial comparing traditional Thai cannabis-based medicine with lorazepam for insomnia treatment
https://pubmed.ncbi.nlm.nih.gov/41736083/

In 3 people with scars, a commercial cosmetic cream combined with CBD & the terpene beta caryophyllene improved scar tissue
Early Physiotherapy of Post‐Surgical Scars Using a Topical Cannabidiol (VeroDol CBD) Cream Gel: Three Case Reports
https://pmc.ncbi.nlm.nih.gov/articles/PMC12937039/

In people eating hemp seeds for 4 weeks, they had improved fatty acid levels in their blood
The effect of hemp product consumption on blood fatty acid profiles and cardiovascular disease risk factors: Results of a randomized, double-blind, crossover clinical trial
https://pubs.rsc.org/en/content/articlepdf/2026/fo/d5fo04672f

📑 Reviews 📑

In caregivers for older adults, a review found they used cannabis to cope with the high levels of stress or emotional burden
Cannabis Use Among Caregivers of Older Adults: A Systematic Literature Review
https://journals.sagepub.com/doi/pdf/10.1177/30495334261426511

In oncology, a book chapter on the cannabinoids by canna-hero Dr. Donald Abrams
Cannabis and cannabinoids in integrative oncology
https://www.sciencedirect.com/science/chapter/edited-volume/abs/pii/B9780443301940000436
And in breast cancer, a review how the cannabinoids combine with other treatments
Cannabinoids in Combination with Conventional Breast Cancer Therapies: Mechanistic Insights and the Gap to Clinical Translation
https://www.mdpi.com/2072-6694/18/5/761

In drug-resistant epilepsy, a review on the potential of CBG
Elucidating the Putative Role of Cannabigerol: A Hypothesis-Generating Review of Neuroinflammatory and Neuroprotective Mechanisms with Implications for Drug-Resistant Epilepsy
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1755956/abstract

For Alzheimer’s disease, a review of combining cannabis with the terpene linalool from lavender
Exploring Linalool-Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer’s Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition
https://pubmed.ncbi.nlm.nih.gov/41735175/

For Alzheimer’s, a book chapter on cannabinoids modulating the microglia (guardian immune cells of the brain)
Cannabinoids as modulators for Alzheimer’s disease: a role for microglia?
https://www.sciencedirect.com/science/chapter/edited-volume/abs/pii/B9780443273407000024

On drug use in musicians, a review on why they use more alcohol & cannabis
Alcohol and Drug Use in Musicians: A Systematic Review
https://www.ingentaconnect.com/contentone/scimed/mppa/2026/00000041/00000001/art00004

In dental stem cells, a review of how CBD improved their viability, proliferation, migration & differentiation
Bioactivity and Regenerative Potential of Cannabidiol in Human Dental Pulp Stem Cells: A Scoping Review of In Vitro Studies
https://pmc.ncbi.nlm.nih.gov/articles/PMC12937086/

For the long-term psychiatric effects of synthetic cannabinoids, a review of 58 studies found more psychosis & prolonged psychotic episodes, as well as data on cathinones & the psychedelic series NBOMe
Acute and Long-term Psychiatric Consequences of Synthetic Cannabinoids and Related Novel Psychoactive Substances: A Systematic Review
https://www.sciencedirect.com/science/article/abs/pii/S0165178126001174

⚠️ Harms ⚠️

In brain scans of chronic cannabis users, they had higher scores for impulsivity correlated with an emotional dysregulation pattern as well as reduced volume in the hippocampus (a memory center of the brain), the amygdala (an emotional processing center) & other brain reward system regions
The relation between emotional regulation, impulsivity and the morphometric changes in brain reward system structures in cannabis use disorder
https://openurl.ebsco.com/EPDB%3Agcd%3A14%3A24259950/detailv2

In adults & adolescents who use cannabis, brain scans found reduced non-drug reward anticipation activity in the ventral striatum (processing of stimuli, reward & predictions)
The association between cannabis use and brain reward anticipation: a 12-month longitudinal study of adults and adolescents who use cannabis and age-matched controls
https://www.nature.com/articles/s41386-026-02377-3

In young adults with HIV, heavy use of cannabis was associated with worse performance on fluid cognition, immediate & delayed word list recall, processing speed & executive functions
Cannabis use frequency may differentially impact cognitive performance in young adults with and without HIV
https://www.frontiersin.org/journals/adolescent-medicine/articles/10.3389/fradm.2026.1716084/abstract

In people with HIV, a transcriptional genetic analysis found changes associated with inflammatory genes & immunomodulation
A single-nucleus multiome analysis of transcriptome and chromatin accessibility reveals cell-type-specific immune modulation for chronic cannabis use among people with HIV infection
https://www.biorxiv.org/content/biorxiv/early/2026/02/27/2026.02.26.708082.full.pdf

In people with cannabinoid hyperemesis, a survey found they had the highest prevalence of suicidal thoughts compared to other classes of cannabis users
Elevated suicidal thoughts and behaviors among adults reporting symptoms of Cannabinoid Hyperemesis Syndrome: Results from a national survey of US adults
https://www.medrxiv.org/content/medrxiv/early/2026/02/28/2026.02.26.26347185.full.pdf

In people with cannabinoid hyperemesis syndrome, this survey found they had higher rates of other drug use as well as more depression, anxiety, sleep problems, chronic pain, antisocial behavior, intimate partner violence & disinhibited personality traits than other frequent or infrequent cannabis users
Links between Cannabinoid Hyperemesis Syndrome symptoms and drug use, mental health problems, antisocial behavior, and personality in a national survey of adults in the United States
https://www.medrxiv.org/content/10.64898/2026.02.26.26347188v1.full.pdf

In a young person with cannabinoid hyperemesis & maturity-onset diabetes of the young, a case report on his unusually rapid progression to end-stage renal disease
The Interplay of Maturity-Onset Diabetes of the Young, Obesity, Uncontrolled Hypertension, and Cannabinoid Hyperemesis in the Progression to End-Stage Renal Disease: A Case Report
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1755934/abstract

In Chinese cases of cannabis use disorder, incidence has increased since 1990
Cannabis Use Disorders in China from 1990 to 2040: Incidence Trends and Future Projections
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2634983

For prenatal cannabis exposure, public health data found a number of brain volume differences “including smaller amygdala, thalamic, and cerebellar vermis volumes and larger caudate, hippocampal, and cerebellar cortex volumes”, with greater changes associated with 3^rd trimester exposure, including white matter microstructure alterations
Associations of Prenatal Cannabis Exposure and Neonatal Brain Development in the HBCD Cohort
https://www.medrxiv.org/content/10.64898/2026.03.02.26347436v1

In prenatal cannabis exposure, the infants had reduced birth weights & were small for gestational age
Associations Between Prenatal Cannabis Exposure and Birth Outcomes: Results from a Prospective Cohort Study
https://www.medrxiv.org/content/10.64898/2026.03.01.26347369v1

In a rat model of prenatal THC exposure, the females consumed more alcohol initially, while the males initially drank less but progressively escalated their consumption (though never reaching as much as the females), with gendered differences in the changes to their endocannabinoid signaling
Prenatal THC exposure and binge-like alcohol drinking in early adolescence: From sex-specific drinking vulnerability to abnormal endocannabinoid-dopamine nexus in the nucleus accumbens
https://journals.sagepub.com/doi/abs/10.1177/02698811261420097

In lung cells, vaping delta-8 THC induced early stress genes, activated fibrosis (scarring) signaling & suppressed programs of the mitochondria (powerhouse of the cell) & ribosomes (protein assembly organelles)
Transcriptomic and Functional Responses of Human Airway Cells to Vaped ∆8-THC and its Oxidation Product ∆8-THCQ
https://www.researchsquare.com/article/rs-8790511/v1

🐁 Preclinical 🐁

For cannabis inducing oxidative stress, this meta-analysis of 51 preclinical studies found cannabis exposure associated with a small increase in reactive oxygen species production & lipid breakdown as well as a reduction of antioxidant enzymes
Preclinical Evidence of Cannabis-Induced Oxidative Stress: A Systematic Review and Meta-Analysis
https://www.sciencedirect.com/science/article/pii/S0273230026000401
Haha. Last week we had cannabis users with higher levels of both pro-& anti-inflammatory cytokines. And this week we have (not hugely convincing) evidence that the these cannabinoids renowned for their antioxidant abilities may be (sometimes) increasing oxidative stress markers.

In a mouse model of THC tolerance, the first days of THC led to hypothermia & reduced motor activity, but tolerance developed by day 3
Time Course of the Development and Loss of Delta-9-tetrahydrocannabinol Tolerance: Effects on Hypothermia and Spontaneous Locomotor Activity in Mice
https://pubmed.ncbi.nlm.nih.gov/41748149/
A small but intriguing piece of evidence that when old stoners say they drive just as well after smoking, it might just be true.

In a mouse model of methamphetamine use disorder, CBD reduced anxiety & cognitive deficits via neuroprotection of the brain, especially the hippocampus (a memory center of the brain)
Cannabidiol attenuates methamphetamine-induced psychosis via anti-oxidative stress: σ1R-mediated mitochondrial dysfunction as a critical pathway
https://www.sciencedirect.com/science/article/abs/pii/S0944711326002527
And in a rat model of methamphetamine use disorder, blocking the CB1 receptor reduced anxiety-like behavior, improved decision-making performance & enhanced social interactions while activating the CB1 receptor did not significantly alleviate behavioral impairments induced by methamphetamine
Involvement of CB1 cannabinoid receptors in methamphetamine-related decision-making and social behavior deficits
https://pubmed.ncbi.nlm.nih.gov/41731375/

In a mouse model of Alzheimer’s disease, CBD restored their social recognition memory
Effects of Chronic 100 mg/kg Cannabidiol Treatment in Male Double Transgenic APPSwe/PS1∆E9 Mice
https://www.mdpi.com/1424-8247/19/3/374

In a mouse model of inflammatory pain & morphine use disorder, CBD produced a significant reduction in pain behaviors
Potential effects of cannabidiol on formalin-induced inflammatory pain in morphine-dependent rats
https://www.sciencedirect.com/science/article/abs/pii/S0022395626001263

In a mouse model of chronic pain, CBD reduced their response to chemical stimuli via their pain-sensing circuits & sodium channels
The parabss1 Drosophila melanogaster as Model for Chronic Nociception: Insights Into Cannabidiol Analgesic Effects
https://harvest.usask.ca/server/api/core/bitstreams/52d3d0ff-ebe9-4a1f-ae92-e26d428ccad8/content

In a female rat model of liver disease from a sugar-rich diet, cannabis oil improved liver lipid metabolism, reduced fatty liver disease scores, lowered scarring, lessened oxidative stress & normalized the liver levels of the CB1 receptor & endocannabinoids
Cannabis oil modulates liver alterations and endocannabinoid system changes in a female rat model of diet-induced MASLD
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1770150/abstract

In a rat model of early-stage liver inflammation from a high-fat diet, CBD reduced inflammation & prevented the development of metabolic dysfunction-associated steatohepatitis (MASH)
Therapeutic potential of cannabidiol supplementation in mitigating lipid precursors of inflammation in hepatic steatosis progression
https://pubmed.ncbi.nlm.nih.gov/41742322/

In male mice, on how CBG moved through their body & that the effects on anxiety are not via the CB1 receptor
Pharmacokinetic and pharmacodynamic properties of cannabigerol in male mice
https://www.sciencedirect.com/science/article/pii/S0022356526005070

In a mouse model of exposure to radiation, hempseed oil “exhibited outstanding radio-protecting function”
Hemp seed oil mediates injury mitigation and anti-inflammation in radiated splenic T cells
https://www.sciencedirect.com/science/article/abs/pii/S0944711326002412

In a mouse model of pancreatic toxicity due to the foodborne mycotoxin ochratoxin A, the terpene beta caryophyllene markedly reduced pancreatic damage, augmented antioxidant defenses & inhibited inflammasome signaling
β-Caryophyllene Protects Against Foodborne Ochratoxin A–Induced Pancreatic Toxicity: Implications for Food Safety and Environmental Health
https://www.researchsquare.com/article/rs-8885289/v1

In a rat model of mechanical pain, DMT reduced pain via the serotonin, opioid & nitric oxide & CB2 receptors
Antinociceptive effect of N,N-dimethyltryptamine (DMT) involving serotonergic, opioidergic, cannabinoidergic, and nitrergic systems in PGE2-induced hyperalgesia in rats
https://www.probiologists.com/article/antinociceptive-effect-of-n-n-dimethyltryptamine-dmt-involving-serotonergic-opioidergic-cannabinoidergic-and-nitrergic-systems-in-pge2-induced-hyperalgesia-in-rats

🆕 Novel Studies 🆕

(a grab bag section for cool & new stuff)

In secondhand cannabis smoke, on the levels of cannabinoids & polycyclic aromatic hydrocarbons (which were greatly lower than tobacco - but working in this level for 8 hours would exceed the California limits)
Polycyclic aromatic hydrocarbons and cannabinoids in secondhand cannabis smoke
https://www.sciencedirect.com/science/article/pii/S0160412026001339

For air quality monitoring of cannabis smoke, on an electrochemical gas sensor for THC
An Electrochemical Gas Sensor for Δ9-Tetrahydrocannabinol in Cannabis Smoke: A Novel Approach for Air Quality Monitoring in Legal Cannabis Consumption Areas
https://pubs.acs.org/doi/abs/10.1021/acs.analchem.5c06148

For potassium channels (key for cardiac & brain signaling), on how CBD inhibits them in different ways
Cannabidiol inhibits both human KV7.1 and KV7.1/KCNE1 channels through distinct sites
https://www.nature.com/articles/s41401-025-01742-0

📰 US Headlines & Fav Articles

At the Supreme Court, the justices heard arguments about the current gun ban for cannabis users (and seemed dubious. What is a ‘habitual drunkard’ anyway?)
https://www.marijuanamoment.net/listen-live-supreme-court-hears-case-on-marijuana-users-second-amendment-gun-rights-as-trump-doj-defends-ban/
https://cannabismusings.substack.com/p/cannabis-musings-march-4-2026
https://toddharrison.substack.com/p/the-supreme-court-passed-the-vibe
https://www.realclearpolitics.com/articles/2026/03/02/from_whiskey_to_weed_a_second_amendment_fight_153892.html
Good old Justice Elena Kagan even brought up the hypothetical of, what if a person infrequently used ayahuasca?
Which makes one hope that Justice Kagan herself has tried ayahuasca. In fact, judging by her quotes, I’d lay even odds that she has (“If the drug is ayahuasca, and it’s a very, very, very intense hallucinogen—and the episode lasts a very long time, … but when you’re in its grip, reality dissolves.”)
Unfortunately, Kalshi doesn’t have a prediction market for “Elena Kagan admits to ayahuasca usage”. But they do have one for SCOTUS upholding the cannabis gun ban & as of now, only 17% think they will, with a big cliff where the hearings began.

The Department of Transportation reminded substance abuse professionals that, according to federal drug testing policies, they cannot justify positive THC tests due to a worker’s use of medical cannabis or hemp extracts
https://www.marijuanamoment.net/use-of-medical-marijuana-or-hemp-doesnt-excuse-drug-testing-violations-trumps-transportation-department-warns/

A lovely piece of journalism on the hunt for a famed California cultivar & a meditation on the nature of oral history amidst a savage prohibition that made record-keeping dangerous
https://www.sfgate.com/cannabis/article/big-sur-holy-weed-21350979.php

In Milwaukee, a judge was displeased with the smell of cannabis in the courtroom & said “anybody that thinks it’s a good idea to get high before you come to court really needs a reality orientation”
https://cannabislaw.report/milwaukee-judge-not-happy-with-smell-of-weed-in-the-courthouse-during-sentencing-hearing-anybody-that-thinks-its-a-good-idea-to-get-high-before-you-come-to-court-really-needs-a-reality-orientatio/
I get where he’s coming from, but you can’t ignore the possibility that the smell might be coming from people who need cannabis medically.

‘Ten Black Heroes Behind Cannabis Legalization’
https://parabolacenter.substack.com/p/ten-black-heroes-behind-cannabis

On cannabis in Japan, by cannabis lawyer Bob Hoban who just traveled there
https://hightimes.com/travel-hospitality/standing-on-the-moon-in-japan-hemp-history-long-game/

History Corner: 1980: Paul McCartney: “Everyone said, ‘Whatever you do, don’t take any pot into Japan. Seven years hard labor.’ But we were in New York, and we had this pot…”
“Oops.”
https://decider.com/2026/02/27/paul-mccartney-arrested-jail-time-japan-marijuana-man-on-the-run/

🌐 International Updates 🌐

In France, their medical cannabis reimbursement plan was revealed
https://businessofcannabis.com/cannabis-europa-paris-2026-frances-medical-cannabis-reimbursement-plans-revealed/
And pushback: “built for patients or for regulators?”
https://businessofcannabis.com/frances-medical-cannabis-framework-built-for-patients-or-for-regulators/

In Canada, the government reported that cannabis added $11.5B to the country’s GDP
https://stratcann.com/news/cannabis-industry-contributes-nearly-11-6-billion-to-canadas-2025-gdp/

In Uruguay, an analysis of 10 years of regulated cannabis social clubs (CSCs)
A decade of regulated Cannabis Social Clubs in Uruguay: five key developments and challenges ahead
https://www.sciencedirect.com/science/article/pii/S0955395926000654
“First, the number of CSCs and their registered members has steadily increased, reflecting both sustained demand and institutional stability. Second, while CSCs remain concentrated in Montevideo and the coastal region, their geographical presence has expanded, and they now operate in every Uruguayan province. Third, most CSCs have shown remarkable longevity, with relatively few closures —suggesting the stability of the model over time. Fourth, CSCs have played a consistent and significant role in the volume of cannabis distributed legally in the country, often approaching or even surpassing the cannabis volume sold in pharmacies. And fifth, although accessing cannabis through CSCs tends to be more expensive than through pharmacies, their product diversity and cultivation practices continue to attract members, reinforcing their position within the legal supply ecosystem.”

In Latin America, an analysis “challenge[d] the notion that personal contact with drug market participants fosters prohibitive attitudes” & that legalizing drugs would trigger significant public backlash
From Social Proximity to Policy Preferences: Contact with Drug Market Participants and Citizens’ Attitudes Toward Drug Policy
https://academic.oup.com/poq/advance-article-abstract/doi/10.1093/poq/nfaf067/8502184

In Brazil, an analysis of the statements of Congresspeople on cannabis
Do uso humano da Cannabis sativa: o que dizem os parlamentares brasileiros sobre o tema? [On the human uses of Cannabis sativa: what do Brazilian Congressmen say about the subject?]
https://www.scielosp.org/article/csc/2026.v31n2/e17732023/en/

“Ghana legalised hemp and regulated it like cocaine” - Amanda Clinton
https://cannabislaw.report/opinion-amanda-clinton-writes-ghana-legalised-hemp-and-regulated-it-like-cocaine/
And more on the state of hemp & the extremely high license fees (up to $45k per hectare)
https://cannabislaw.report/article-hemp-is-legal-in-ghana-but-can-farmers-actually-enter-the-market-farmer-take-govt-to-court/

In South Africa, a Cape Town city employee won a ~$30k arbitration that he was unfairly fired for cannabis consumption
https://iol.co.za/news/crime-and-courts/2026-02-21-labour-court-rules-in-favour-of-officer-dismissed-for-cannabis-use-with-r553-000-backpay/

In Kenya, a lawyer petitioned the court to bar Rastafarians from bringing cannabis into the courtroom
https://cannabislaw.report/kenya-lawyer-petitions-court-to-bar-rastafarians-from-bringing-cannabis-into-courtroom/

⚖️ Business, Laws & Education ⚖️

On the shift to schedule III being “treated as a transitional status” & on the effects on research by Piomelli
A Schedule Shift, Not a Federal Green Light: What Cannabis Rescheduling to Schedule III Would Mean—and What It Would Not
https://journals.sagepub.com/doi/full/10.1177/25785125261424697

In Massachusetts, an analysis of the most commonly cited regulation violations
https://talkingjointsmemo.com/the-most-commonly-cited-cannabis-control-commission-violations/

For the marketing of cannabis, a review of 52 studies across the US & Canada
Cannabis marketing in Canada and the USA, a scoping review
https://www.emerald.com/dhs/article-abstract/doi/10.1108/DHS-04-2025-0022/1344569/Cannabis-marketing-in-Canada-and-the-USA-a-scoping

The first cannabis industry retirement report
https://www.leadingretirement.com/cannabis-industry-retirement-report/

For US state adult-use cannabis laws, an analysis of the 4 types
Beyond legalization: characterizing distinct recreational cannabis regulatory approaches across US states, 2013-2024
https://www.medrxiv.org/content/10.64898/2026.02.26.26346986v1

🚓 The War on Drugs 🚓

On Trump’s boat strikes, the Inspector General delayed a proposal to evaluate the military targeting of the strikes
https://www.nytimes.com/2026/02/28/us/politics/trump-boat-strikes-pentagon.html

In Mexico, President Sheinbaum “insists she’s not waging a ‘war on drugs’” despite ramping up military operations against cartels
https://www.latimes.com/world-nation/story/2026-03-03/in-mexico-no-war-on-drugs-sheinbaum-vows-but-crackdown-on-narcos-signals-clear-turnaround
The back story here is illuminating. Her predecessor López Obrador instituted the controversial “hugs not bullets” approach of focusing on poverty & this emboldened cartels to increase their violence & control. With many Mexicans in favor of US intervention to help control the cartels, which she sees as interference in Mexico’s sovereignty, Sheinbaum is proving that Mexican forces can take down high-value targets such as Oseguera last month. But she’s seen as falling short in one of the big challenges: getting rid of the corrupt politicians & law enforcement officials backed by the cartels, especially those linked to her own party.

For René Arzate-Garcia, a leader in the Sinaloa cartel, the US offered a $5M reward for his arrest & conviction because of his alleged control of the Tijuana corridor
https://www.latimes.com/california/story/2026-02-26/narco-terrorism-charges-filed-against-sinaloa-cartel-leaders

In Ecuador, the US launched joint operations to combat drug trafficking
hin Mexico,ttps://www.theguardian.com/us-news/2026/mar/04/us-military-action-operation-ecuador

For drug trafficking through Caribbean ports, a case study of the Dominican Republic’s success in port security
Narcos of the Caribbean: Addressing Transshipment Drug Trafficking Through Caribbean Ports
https://ecollections.law.fiu.edu/cgi/viewcontent.cgi?article=1773&context=lawreview

In the Indian Ocean, an analysis of the drug trafficking
Seaborne Narcotics: Mapping the Maritime Drug Trade in the Indian Ocean and Its Security Implications
https://www.marseccoe.org/wp-content/uploads/2026/02/5th-Maritime-Security-Proceedings.pdf

In Malaysia, a college lecturer was caught with 200+ grams of cannabis & faces life imprisonment & at least 10 strokes of the cane
https://cannabislaw.report/malaysia-college-lecturer-charged-with-possessing-over-200g-of-cannabis-punishable-under-section-39a2-of-the-same-act-carries-life-imprisonment-or-a-minimum-of-five-years-jail-and-at-least/

In Zimbabwe, two football stars were caught with 750 kg of cannabis & given 12-year jail terms
https://cannabislaw.report/zimbabwe-ex-kaizer-chiefs-soccer-star-caught-with-750kg-of-cannabis-handed-jail-sentence/

WoD History

In the Soviet Union, a history of their War on Drugs
https://hightimes.com/culture/inside-the-soviet-unions-war-on-drugs/

For the Kurdistan Workers’ Party, on their role in drug trafficking
Influence of Regional and Global Dynamics on Drugs & Conflict Nexus and Vice Versa: The Case of PKK
https://ebooks.iospress.nl/doi/10.3233/NHSDP260020

🚗 Driving 🚗

For driving under the influence of cannabis, on the social acceptability of various scenarios
Exploring public perceptions of dangerousness and social acceptability of driving under the influence of cannabis
https://www.tandfonline.com/doi/abs/10.1080/09687637.2026.2634870

For detecting impairment from cannabis use, on using machine learning to combine multiple sources of data
Making highways and workplaces safer: An interpretable machine learning approach to predicting recent cannabis use and impairment
https://www.sciencedirect.com/science/article/abs/pii/S0022437526000368

🛡️ Harm Reduction News 🛡️

On harm reduction for adolescents, an interview & book review of ‘Harm Reduction Approaches With Adolescents Who Use Substances’ by friends of the newsletter Amanda Reiman & Barry Lessin
https://filtermag.org/harm-reduction-teen-drug-use/

On a hero of harm reduction, a bit of a funny interview with the pioneer Dr. David Nutt (I’ve always appreciated his curmudgeonliness, as well as the fact that he signed my William James book at a conference 15 years ago)

Disobedient Margins

The Man with the Scale: David Nutt and the Weight of Things

It was probably a cold morning in Bristol. The kind of chill that doesn’t stop at the skin. The responses came in like reports nobody wants to read: abrupt, loud, all caps. As if urgency alone might pierce the screen…

6 months ago · 13 likes · 1 comment · Claudio Teixeira

For the overdose crisis, on the ability of new technologies to help
https://reason.org/commentary/can-technology-help-reduce-harm-caused-by-americas-overdose-crisis/
Personally, I was most intrigued by the digital overdose-prevention platforms.

An editorial on the lack of evidence for involuntary substance use treatment
https://medicalxpress.com/news/2026-03-decades-reveal-involuntary-substance-treatment.html

In Indiana, lawmakers will require people to show IDs to use the state’s needle exchange programs, though the governor still needs to sign the bill
https://mirrorindy.org/indiana-needle-exchanges-drugs-opoid-crisis-michael-crider-mike-braun/

In Newfoundland & Labrador, Canada, a new smart harm reduction vending machine
https://www.cbc.ca/news/canada/newfoundland-labrador/a-new-smart-vending-machine-in-stephenville-could-help-save-lives-9.7105810

Harm Reduction Research

In the neighborhoods of NYC’s overdose prevention centers, a micro-level analysis found no change in foot traffic or consumer spending
Overdose Prevention Centers, Disorder, and Economic Activity
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845605

Overdose Prevention Centers and Neighborhood Commercial Activity in New York City
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845604

For the festival workers at UK music festivals, interviews on their perspectives on drug use & harm reduction
Perspectives on recreational substance use and harm reduction among music festival workers in the United Kingdom: A qualitative study
https://journals.sagepub.com/doi/full/10.1177/20503245261422324

For veterans who inject drugs, a survey about a pharmacist-led harm reduction outreach
Pharmacist-led harm reduction outreach for veterans who inject drugs: A quality improvement evaluation
https://pubs.lib.umn.edu/index.php/innovations/article/view/6978

In a Maryland drug checking program, only 22% of samples contained the drugs people thought they contained
Comparison of anticipated and detected drug contents in samples submitted to a statewide drug checking program in Maryland, USA
https://www.sciencedirect.com/science/article/abs/pii/S0376871626000840

🍄 Psychoactives, Psychedelics & Plant Medicines 🍄

In US public opinion on legalizing psychedelics, RAND found support of psilocybin mushrooms to be 23% & just 10% for LSD & MDMA
https://www.rand.org/content/dam/rand/pubs/research_reports/RRA4300/RRA4334-2/RAND_RRA4334-2.pdf

The Psychoactive Research

For smokable synthetic cathinone, an online survey of usage patterns & the most frequently reported adverse effects
From dust till dawn: patterns, motives, and risks of using smokable synthetic cathinones
https://pubmed.ncbi.nlm.nih.gov/41742238/

Psychedelics & MDMA

In people with Lyme disease, a pilot study of 2 psilocybin sessions showed significant improvement in symptom burden & quality of life
Pilot study of psilocybin in patients with post-treatment lyme disease
https://www.nature.com/articles/s41598-026-38091-9

For microdosing in people with depression, 2 months of microdosing psilocybin was safe & well-tolerated but did not cause any differences from the placebo
Safety and Efficacy of Microdosing Psilocybin over 8 Weeks for Major Depressive Disorder: A Randomized Clinical Trial
https://assets-eu.researchsquare.com/files/rs-8319478/v1/60358f62-defe-45d0-8089-f901dd6a3008.pdf

In US veterans, a survey found that psychedelics were associated with changes in spiritual beliefs
Psychedelics are associated with changes in spiritual beliefs and orientations in US veterans
https://www.researchsquare.com/article/rs-8960226/v1

For the complications of psychedelics, a suggested classification system
Classifying Psychedelic-Related Complications
https://pubmed.ncbi.nlm.nih.gov/41749025/

For psychosis from psychedelics, a model of a psychodynamic therapeutic approach
Psychedelic-Related Psychosis: From Model Psychosis to Psychotherapy
https://pubmed.ncbi.nlm.nih.gov/41749024/

For mental disorders, a review of the potential of ayahuasca, DMT & 5-MeO-DMT
Ayahuasca and Its Main Component N,N-Dimethyltryptamine (DMT) for the Treatment of Mental Disorders: Mechanisms of Action, Clinical Studies, and Tools to Explore the Human Mind
https://www.mdpi.com/2227-9059/14/3/506

For predicting the effectiveness of psychedelics for depression, a review of 48 studies found loose consistent correlates to be greater emotional breakthrough, mystical/unitive experiences & ego dissolution-linked reappraisal/insight
Predictors of the Effectiveness of Psychedelics in Treating Depression—A Scoping Review
https://www.mdpi.com/1422-0067/27/5/2202

For psychedelic-assisted therapy, on the synergies with psychotherapy
Synergies in Psychedelic-Assisted Therapy: A Qualitative Interview Study of Psychotherapeutic Processes
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1771726/abstract

On using chaplains in psychedelic therapy, on the competencies that would be helpful
Chaplains in Psychedelic Assisted Therapy: Rationale and Competencies
https://pubmed.ncbi.nlm.nih.gov/41760871/

Ketamine

For older adults with depression & mild cognitive impairment, intravenous ketamine improved depression symptoms
KET-MCI: A Pilot Safety and Tolerability Study of Single Infusion Intravenous Ketamine for Older Adults with Depression and Mild Cognitive Impairment
https://www.sciencedirect.com/science/article/pii/S1064748126000588

For depression, injectable R,S-ketamine had a better safety & efficacy profile than esketamine
Comparative effectiveness and safety of esketamine versus injectable racemic ketamine and oral antidepressants for major depressive disorder: A population-based target trial emulation
https://www.sciencedirect.com/science/article/abs/pii/S0165032726003381

On suicidal ideation in mood disorders, a review on the benefits of ketamine
The Effect of Ketamine infusions on suicidal ideation in various mood disorders
https://pubmed.ncbi.nlm.nih.gov/41736355/

In ketamine for depression, a review of its efficacy & synergy with other treatments
Ketamine pharmacotherapy for major depressive disorder: A narrative review
https://www.sciencedirect.com/science/article/abs/pii/S0278584626000473

On the predictors of responsiveness to ketamine, this review found a number of neural biomarkers predicting responsiveness
Predictors of responsiveness to ketamine: An updated systematic review of neuroimaging findings
https://www.sciencedirect.com/science/article/abs/pii/S0165032726003721
“Fifteen studies were included in this updated review. The anterior cingulate cortex (ACC) and the amygdala emerged as significant regions of interest. Notably, connectivity between the pregenual ACC and other brain regions was frequently associated with better response to ketamine. Furthermore, diffusion MRI showed higher fractional anisotropy in cingulum of responders to ketamine. Structural MRI studies, on the other hand, found that hippocampus volume had a significant positive correlation with response to ketamine. Moreover, proton magnetic resonance spectroscopy showed that responders had a higher Glx/glutamate ratio in the dorsomedial/dorsal anterolateral. Finally, task-based imaging, too, showed that ACC activity was predictive of antidepressant response.”

Kratom

For a dying child, a case report of using kratom to manage end-of-life pain
Parental Self Instrumentation of Kratom as Pain Substitute for the End-of-Life Care in a Malay Child
https://www.researchgate.net/profile/Fahisham-Taib/publication/401238688_Parental_Self_Instrumentation_of_Kratom_as_Pain_Substitute_for_the_End-of-Life_Care_in_a_Malay_Child/links/699ff28912f837212a1f2a6e/Parental-Self-Instrumentation-of-Kratom-as-Pain-Substitute-for-the-End-of-Life-Care-in-a-Malay-Child.pdf

For products with kratom alkaloids, 80 products were found with features appealing to children
Identification and Characterization of Mitragynine or 7-Hydroxymitraynine Oral Dosage Form Products That Appeal to Children
https://jppt.kglmeridian.com/view/journals/jppt/aop/article-10.5863-JPPT-25-00082/article-10.5863-JPPT-25-00082.xml

In withdrawal from the semi-synthetic kratom metabolite mitragynine pseudoindoxyl, a case report on the use of buprenorphine
Mitragynine Pseudoindoxyl Withdrawal Treated with Macro-Dosed Buprenorphine Induction: A Case Report and Review of the Literature
https://www.preprints.org/frontend/manuscript/d2f767771ff901df668adc5a0f63936d/download_pub

In kratom, a computer analysis of the painkilling effects of the minor alkaloids
Computational investigation of minor alkaloids of Mitragyna speciosa Korth leaves as natural opioid analgesics
https://www.tandfonline.com/doi/abs/10.1080/14786419.2025.2570504

🍃 The Plant & its Products 🍃

In Missouri, on the history of hemp
Industrial hemp : history, regulations & licensing
https://mospace.umsystem.edu/items/7a71daf8-dc56-4742-bafe-479bcca37295

🌱 Growing 🌱

For enhancing high-CBD cannabis cultivation, a review of integrating genetic & biotechnological approaches
Integrating Genetic and Biotechnological Approaches to Enhance High-CBD Cannabis sativa L. Cultivation for Medicinal Purposes
https://pubmed.ncbi.nlm.nih.gov/41741936/

For the regulation of cannabis flowering, a review of the mechanisms, pathways & related genes
Research Progress on Flowering Period of Hemp
https://www.mdpi.com/2223-7747/15/5/682

When adding salicylic acid to cannabis before harvest, it promoted the levels of THC, flavonoids, antioxidants, phenols & pigments
Preharvest Salicylic Acid Application Enhances Pigments, Antioxidants, and Secondary Metabolites in Cannabis sativa L.
https://www.mdpi.com/2311-7524/12/3/276

For the breakdown of cannabinoids by UV light, on the significant photodegradation
UVA and UVB Photolysis of Natural and Synthetic Cannabinoids Studied by Online Mass Spectrometry
https://www.mdpi.com/1420-3049/31/5/813

For photoautotrophic micropropagation (sugar replacing CO2 as carbon source) of medical cannabis plantlets, on optimizing the process for vigorous, pathogen-free production
Synergistic optimization of CO2 enrichment and air exchange enhances growth of medicinal cannabis plantlets in photoautotrophic micropropagation
https://www.sciencedirect.com/science/article/pii/S0926669026003286

For drying hemp, on optimizing CBD content when using vacuum heat pump drying
Response Surface Optimization of Cannabidiol Extracted from Hemp by Vacuum Heat Pump Drying
https://www.espublisher.com/journals/articledetails/2082

In Slovenian hemp, on the effects of sowing date & pruning systems on yield & cannabinoid composition
From breeding to practise: Effects of sowing date and pruning system on flower yield and cannabinoid composition in four Slovenian feminized industrial hemp breeding lines
https://journals.uni-lj.si/aas/article/view/26115/21080

For the cannabis of Ecuador, on the effects of substrate composition on germination & early vegetation
Substrate evaluation in the germination of Cannabis sativa L. seeds up to stage V3, Cotopaxi, Ecuador
https://revistas.untrm.edu.pe/index.php/INDESDOS/article/view/1172/1618

In Missouri hemp, on the best production practices
Harvesting industrial hemp : general considerations
https://mospace.umsystem.edu/items/7430b56e-f76b-49a6-bcc5-fa46aa47328b

In Missouri, on the insect pests of hemp
Insect pests of industrial hemp in Missouri
https://mospace.umsystem.edu/items/3766d991-dfb0-4baf-b9a3-9a34f483acba

For CBC in hemp cultivars, an analysis of the variations in its levels
Cannabichromene variation in hemp cultivars
https://acsess.onlinelibrary.wiley.com/doi/pdf/10.1002/csc2.70241

⚙️ Extracting, Analyzing & Formulating ⚙️

For the stability of dried cannabis flower, nitrogen-modified atmosphere packaging in aluminum bags was more effective at improving stability than polyethylene jars
Comparative stability of dried Cannabis sativa L. flower in N2-flushed aluminum laminate bags versus HDPE jars under ICH long-term storage conditions
https://openurl.ebsco.com/EPDB%3Agcd%3A10%3A37401882/detailv2

For analyzing cannabinoid levels in commercial products, on an UHPLC-DAD method
Simultaneous quantitative analysis of epimeric and Δ8/Δ9 positional isomers of synthetic THC analogs and natural cannabinoids in formulated products by UHPLC-DAD with optional ESI/TOFMS confirmation
https://www.tandfonline.com/doi/abs/10.1080/10826076.2026.2636540

For differentiating hemp stems versus buds, on using an ATR-FTIR spectroscopy approach
Application of FT-IR IS50 ATR spectroscopy for differentiating hemp stem and bud chemical composition: A rapid screening approach
https://www.researchgate.net/profile/Joshua-Animasaun-2/publication/401371389_Application_of_ft-ir_IS50_ATR_spectroscopy_for_differentiating_hemp_stem_and_bud_chemical_composition_A_rapid_screening_approach/links/69a3b40d16faea00ba9b274b/Application-of-ft-ir-IS50-ATR-spectroscopy-for-differentiating-hemp-stem-and-bud-chemical-composition-A-rapid-screening-approach.pdf

For microencapsulating the cannabinoids, a review of approaches
Microencapsulation techniques for cannabinoids: pharmaceutical approaches, technological challenges, and formulation perspectives
https://aseestant.ceon.rs/index.php/arhfarm/article/view/62381

On creating cannabis tablets that are liquisolid
Liquisolids as a platform for the formulation of cannabis tablets
https://www.sciencedirect.com/science/article/pii/S2590156726000289

For converting hemp hurd lignin & cellulose, a comparison of chemical pretreatment methods
Low-Concentration Chemical Pretreatment of Lignocellulose Biomass Derived from Hemp Hurds, Agricultural Waste: Comparative Characterisation of Various Pretreatment Methods
https://www.mdpi.com/1996-1944/19/5/843

🍞 Food & Nutrition 🍞

In brewing with hemp seeds, on the effects on the aroma
Aroma Profile of Worts and Contents of Selected Mineral Elements in Brewing with Malted and Unmalted Hemp Seeds
https://www.mdpi.com/1420-3049/31/5/809

For frankfurters, on adding hemp seed cake as a phosphate replacer
Evaluating the additive effects of psyllium husk powder combined with micronized cold-pressed hemp seed cake on the quality profile and in vitro digestibility of reduced-phosphate frankfurters
https://www.sciencedirect.com/science/article/abs/pii/S0309174026000458

For hempseed milk, on optimizing the process for thermal stability
Process Optimization of Thermal Stability for Hemp Seed Milk Produced from Whole Fat and Fat-Reduced Seeds
https://www.mdpi.com/2227-9717/14/5/783

In laying hens, hempseed meal improved their feed efficiency, egg production, shell quality & yolk fatty acid enrichment
Effect of hot and cold processed hempseed (Cannabis sativa) meal on productive performance, egg quality, egg yolk fatty acid and blood biochemical in laying hens
https://www.sciencedirect.com/science/article/pii/S0032579126003196

🏗️ Industrial Uses & Fiber 🏗️

For polylactic acid biocomposites, on the effects of hemp granules on reinforcement
Hemp Granule Size and Mass Fraction Effects on the Rheological, Thermal, and Mechanical Behavior of PLA-Based Biocomposites for Thermoforming
https://www.mdpi.com/2504-477X/10/3/115

For hemp-lime biocomposites for insulation, on the effect of adding recycled waste cardboard chips
Effect of recycled waste cardboard chips on the physico-thermal-hygric properties of hemp-lime biocomposites
https://www.sciencedirect.com/science/article/pii/S2590123026008121

In a comparison of bio-based building materials, hemp was the most effective insulation system in cold regions
Thermal mass vs. insulation trade-off in bio-based buildings: Climate-dependent energy performance of hemp, straw, and wood-based constructions
https://www.sciencedirect.com/science/article/abs/pii/S037877882600294X

For producing bio-based materials, on the sustainability of hemp hurds
Structural and Chemical Profiling of Hemp Hurds for Sustainable Bioproducts Within a Circular Economy Framework
https://www.mdpi.com/2071-1050/18/5/2197

For quantifying hemp fiber length, on using machine learning
Machine learning-inspired image processing for accurate length characterization of complexly crossed hemp fibers
https://link.springer.com/article/10.1007/s10570-026-06987-4

For cement, on the mechanical performance changes from hemp fiber reinforcement
Enhancing Mechanical Performance of Hemp Fiber-reinforced Cementitious Composites: Experimental and Numerical Investigations Using RSM
https://pp5.omikk.bme.hu/ci/article/view/42126

For cement materials, a thesis project on using hemp shives as an internal curing agent
Utilization of Hemp Shives as an Internal Curing Agent in Cementitious Materials
https://tdl-ir.tdl.org/items/82a14f80-4573-44c9-a188-0dde1ec47faa

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

In California, a workshop on advancing cannabis research
Advancing Cannabis Research in a Changing Landscape: Meeting Summary of the 2025 California Cannabis Research Workshop
https://journals.sagepub.com/doi/full/10.1177/25785125261417167

🏥 Public Health, Legalization Effects & Bioassays 🏥

In Hispanic/Latine adults, more experiences of racism were correlated with greater coping-motivated cannabis use & cannabis -related problems
Racism and Cannabis-Related Problems Among Hispanic/Latine Adults: The Role of Negative Emotions in Responses to Experiencing Racism
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2630211

🧒 Adolescents & Young Adults 🧒

For school climate, more cannabis use was associated with difficulties overcoming challenges, problems controlling temper & becoming angry easily & in terms of both cannabis & alcohol, gang membership, skipping school, violent behavior, school-parent & school-student engagement & gambling
Leveraging Machine Learning to Understand the Link Between School Climate and Youth Substance Use: a Focus on Cannabis and Alcohol Use
https://pubmed.ncbi.nlm.nih.gov/41762379/

In adolescents, family conflict predicted increased positive cannabis expectancies with increases in negative urgencies via the anterior cingulate cortex (emotional & cognitive processing)
Negative Urgency Mediates the Effect of Family Conflict on Cannabis Positive Expectancy: The Moderating Role of Anterior Cingulate Cortex
https://pmc.ncbi.nlm.nih.gov/articles/PMC12935555/

In adolescents, frequent social media use was associated with 3x higher odds of cannabis use
Causal pathways from social media use to adolescent cannabis use: An instrumental variable mediation analysis of behavioral problems
https://www.sciencedirect.com/science/article/pii/S2949875926000482

In youth with bipolar disorder & cannabis use disorder, on the changes to their brain region volumes
Association of polygenic risk for cannabis use disorder with brain structure among youth with and without bipolar disorder
https://journals.sagepub.com/doi/abs/10.1177/02698811261424206

In Swedish adolescent cannabis use, a survey found confirmation of the total consumption model & the theory of collectivity
Does the total consumption model apply to cannabis use?
https://onlinelibrary.wiley.com/doi/pdf/10.1111/add.70353

🧠 The Brain & Neurological Disorders 🧠

In a rat model of repetitive mild traumatic brain injury, this thesis project found that drugs that activated either the CB1 receptor or the TRPV1 receptor (of the vanilloid family, like the endocannabinoid anandamide) reduced the deficits in synaptic plasticity
Analysis of synaptic plasticity events concerning the endocannabinoid system in the young adolescent (YA) rat media perforant pathway (MPP) following repetitive mild traumatic brain injury (r-mTBI)
https://dspace.library.uvic.ca/items/16fd861b-9151-492f-96c8-83ad84e13ed5

In the nucleus accumbens (a reward center & regulator of feeding, stress & motivation) of male mice, injections of low doses of THC increased signaling of dopamine & GABA (the brain’s most common inhibitory neurotransmitter) while high doses decreased dopamine signaling
Dopamine, γ-aminobutyric acid, and glutamate balance in the nucleus accumbens shell: Differential effects of cannabinoid 1 receptor agonists Δ9-Tetrahydrocannabinol, AM11101, and AM8936
https://www.sciencedirect.com/science/article/abs/pii/S002839082600064X

In a rat model of Parkinson’s disease, a new technique for measuring endocannabinoid blood levels found that they had significant alterations to their levels of anandamide & 2-AG
Hydrophobic covalent organic framework as a solid-phase microextraction coating for high-throughput quantification of endocannabinoids in Parkinson’s disease rat plasma
https://www.sciencedirect.com/science/article/abs/pii/S1570023226000851

In a rat model of epilepsy, on analyzing the levels of the CB2 receptor after a prolonged seizure
Evaluation of cerebral cannabinoid type 2 receptors using [11C]RSR-056 PET in a rat model of epilepsy
https://www.sciencedirect.com/science/article/pii/S0361923026000857

In a mouse model of neuroinflammation & neuropathic pain, fatty acid-binding protein 4 (FABP4, and endocannabinoid transporter) was found to be a key contributor to neuropathic pain via inflammation of the brain’s macrophages (a type of immune cell)
Fatty acid binding protein 4 (FABP4): a key player in neuroinflammation and neuropathic pain
https://www.sciencedirect.com/science/article/abs/pii/S0891584926001693

In a tissue model of peripheral nerve injuries, CBD-rich extracts modulated genetic expression of inflammatory & neurotrophic genes
Cannabidiol-rich extract suppresses the activation of proinflammatory genes IL-1β and IL-6 in equine mesenchymal stem cells stimulated with lipopolysaccharide
https://pmc.ncbi.nlm.nih.gov/articles/PMC12932370/

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

For anxiety, the efficacy of medical cannabis was not greatly affected by lifestyle choices or demographics
Associations of cannabis use, other substances, and lifestyle choices on anxiety in medical cannabis patients across 45 days
https://www.nature.com/articles/s41598-026-39086-2_reference.pdf

In a mouse model of memory deficits from sleep deprivation, activating the CB1 receptor promoted a compensatory but maladaptive increase in inhibitory synapse density, leading to a deterioration in synaptic quality
Memory consolidation deficits arise from CB1R-mediated structural–functional decoupling in inhibitory circuits
https://www.sciencedirect.com/science/article/pii/S0969996126000793
“This CB1R-dependent “static over-inhibition but dynamic fragility” erodes circuit resilience and destabilizes memory processing.”

🧬 Reproduction & Hormones 🧬

In the placentas of pregnant people who had the virus of COVID, their levels of the CB1 & CB2 receptors were markedly increased
Altered Endocannabinoid Signaling in Placentas from SARS-CoV-2-Infected Pregnancies
https://www.mdpi.com/2075-4418/16/5/690

In undifferentiated sperm cells, deletion of their CB1 receptors altered homeostasis & endocannabinoid signaling
Endocannabinoids and stemness: a new role for CB1 receptor in the control of Spermatogonial Stem Cell homeostasis
https://www.researchsquare.com/article/rs-8252227/v1

❤️ The Heart & Blood ❤️

In a rat model of heart scarring from the anti-arrhythmia medication amiodarone, the synthetic cannabinoid O-2545 (which activates both CB1 & CB2) reduced scarring
Therapeutic Potential of Cannabinoids in Attenuating Amiodarone-Induced Pulmonary Fibrosis: An in vivo Experimental Study in Wistar Rats
https://www.tandfonline.com/doi/pdf/10.2147/DDDT.S570825

🍽️ The Guts, Nutrition & the Microbiome 🍽️

In anorexia, a review on the involvement of the endocannabinoid, dopamine & orexin systems
Rethinking Anorexia Nervosa Through the Lens of Control, Compulsion and Reward: Neurobiological Insights Into Addiction-Like Features via the Dopaminergic, Endocannabinoid, and Orexinergic Systems - A Narrative Review
https://www.sciencedirect.com/science/article/pii/S0149763426000709

In the guts of chickens, on their distribution of CB2 receptors & the benefit for intestinal motility, oxidative stress & immune functions
Immunofluorescence localization of cannabinoid receptor type 2 in the ileum of juvenile and adult chickens (Gallus domesticus) and its association with gga-mir-200a-3p and oxidative stress
https://www.vetmedmosul.com/article_190457_2f730a4005a15355c9dc77c103e8bdad.pdf

On a mouthwash with tea tree oil, CBD & spilanthol, it had only limited antibacterial & antifungal activities
Comparison of the Antimicrobial Activity of Mouthwashes Containing Tea Tree Oil, Cannabidiol (CBD), Spilanthol, and Chlorhexidine Digluconate Against Selected Bacterial and Yeast Strains: An In Vitro Study
https://www.mdpi.com/2076-3417/16/5/2193

🩸 The Liver, Drug Interactions & Cannabinoid Metabolism 🩸

In people combining cannabis & alcohol, they had elevated hemoglobin levels & liver enzyme abnormalities
Cannabis and Alcohol Use and Their Effects on Hematological and Biochemical Parameters: Evidence From the Accra Psychiatric Hospital, Ghana
https://pubmed.ncbi.nlm.nih.gov/41757343/

👀 The Eyes 👀

In retina cells, blocking the CB1 receptor reduced the production of myofibroblast (a driving factor in scarring)
The Inhibitory Effects of a Peripherally Restricted CB1 Receptor Antagonist on Myofibroblast Transdifferentiation of Human Retinal Pigment Epithelial Cells
https://www.mdpi.com/2073-4409/15/5/418

On a hydrogel containing CBD, hyaluronic acid & ZnO nanoparticles
SMART TOPICAL HA–CBD–ZnO–POLOXAMERS HYBRID GEL: STRUCTURAL, RHEOLOGICAL AND ANTIBACTERIAL INSIGHTS
https://farmaciajournal.com/wp-content/uploads/art-05-Cirloiu-Boboc_Calina_Stoian_48_60.pdf

🖐️ The Skin & Topicals 🖐️

For psoriasis, on encapsulating CBD in an argan oil nanoemulsion
Encapsulation of Cannabidiol in Chitosan-Stabilized Argan Oil Nanoemulsion as a Potential Dermal Drug Delivery System for Psoriasis Treatment
https://www.mdpi.com/1999-4923/18/3/286

🎗️ Cancer & Chemotherapy 🎗️

In skin cancer cells, THC & CBD caused toxicity via the mitochondria (powerhouse of the cell)
THC and CBD Induce Heme Oxygenase-1-Dependent Cell Death and Trigger Mitochondrial Dysfunction in Human Melanoma and Cutaneous Squamous Cell Carcinoma Cells
https://www.mdpi.com/2076-3921/15/3/286

In gastric cancer cells, activating the CB1 or CB2 receptor reduced cell proliferation, lowered viability, impaired migration & induced apoptosis (programmed cellular suicide)
Cannabinoid receptors orchestrate distinct anti-tumour pathways in gastric cancer via and beyond specialized pro-resolving mediators
https://www.sciencedirect.com/science/article/pii/S0753332226002192

In neuroblastoma cancer cells, the endocannabinoid PEA & oleoylethanolamide (the endocannabinoid of satiation) enhanced the treatment efficacy of the Type I interferons (IFNs) via the PPARα nuclear receptors (regulators of genetic transcription)
Oleoylethanolamide and palmitoylethanolamide synergize with IFNβ to potentiate apoptosis and PD-L1 induction in SH-SY5Y neuroblastoma cells
https://iris.unica.it/handle/11584/474587

🔬 Biochemical Discoveries & Research Tools 🔬

On using biomimetic chromatography to better understand how cannabinoids move through the lungs & brain
Biomimetic Partitioning and Pharmacokinetic Insights into Phytocannabinoids
https://pubs.acs.org/doi/full/10.1021/acsomega.5c10320

On creating a fluorescent CB2 sensor
Genetically Encoded CB2R-Based Fluorescent Sensor Enables Rapid Screening and Functional Assessment of Cannabinoid Modulators
https://www.mdpi.com/1422-0067/27/5/2095

For modeling the CB2 receptor, on creating a cellular platform
Tetracycline-Regulated Inducible CB2 Expression in AtT20 Cells: A Functional Assay for Quantifying Ligand Efficacy
https://www.biorxiv.org/content/10.64898/2026.02.26.708391v1

For the colorimetric detection of cannabis at crime scenes, an analysis of how it works
Structural Elucidation of Azo and Quinoneimine Products Formed in Diazonium-Based Color Reactions of Cannabinoids
https://www.mdpi.com/1420-3049/31/5/796

Thanks.
- lex

PS: For queens of the girl group, ‘The Very Best of The Dixie Cups: Chapel of Love’. Made up of the New Orleans sisters Barbara Ann & Rosa Lee Hawkins as well as their cousin Joan Marie Johnson, they first started singing together in grade school & when they released their first song, ‘Chapel of Love’ in 1964, it became a smash hit that sold over 1 million copies. With their lovely harmonies, several other songs over the next few years reached the Top 40, including ‘Iko Iko’, a traditional Mardi Gras tune that their producer recorded of them as they were just clowning around in the studio, singing for fun & using drumsticks on ashtrays. It was their last hit & they moved into modeling careers & work as makeup artists. But over the decades, they continued to tour on the oldies circuit.

This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.
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C&P#178: cannabis for lower back pain, cancer & orofacial pain + OEA for obesity

Lex Pelger WhiteWhaleCreations — Mon, 02 Mar 2026 10:10:16 GMT

Cannabinoids & The People,

or; Drugs & Drug Wars

(buy my canna-graphic novels based on ‘Moby Dick, or; The Whale’ & proceeds go to Americans for Safe Access to support medical cannabis patients)

🌟 This week 🌟

Cannabis for chronic lower back pain & cancer
THC & CBD for orofacial pain
Oleoylethanolamide for the inflammation of obesity
Stoners sit down less!
Ha! Cannabis users have higher levels of both anti-inflammatory & pro-inflammatory cytokines
CHS on the rise in Canada
Treating CUD with transcranial magnetic stimulation
German driving data: half of impaired drivers under THC blood limit & half of unimpaired drivers over it
Preclinical: CBD for blunt force chest trauma, neuropathic pain & heart inflammation

(this week’s numbers: 6.5~k words, ~17 minutes reading time, 139 papers)

Hello everyone,
Welcome to the 178^th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news as well as coverage of other psychoactives, the War on Drugs & harm reduction. Support this work with a paid subscription or by buying me a coffee.