C&P#101: CBD for toothaches & THC for violent dreams
C&P#101: CBD for toothaches & THC for violent dreams
Hemp industry vs cannabis industry cage match
This week…
CBD for toothache pain as well as TMD problems
THC for when your dreams make you yell, kick & punch
Cannabis for fibromyalgia, autism, osteoarthritis & opioid use disorder
Good review on how the cannabinoids alter liver enzyme activity (important for drug-drug interactions)
How the cannabinoids cause neuromodulation
CBD is the first FDA drug to modulate cardiac pacemaker channels
Hello everyone,
Welcome to the 101st edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science + assorted canna-news & psychedelic updates. On the cannabinoids, ask me anything.
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Best Of Cannabinoid Science...
On introducing patients to medical cannabis & THC giving wisdom by friend of the newsletter Dr. Ken Weinberg
https://www.psychologytoday.com/us/blog/bedside-manners/202405/does-thc-give-you-wisdom
“I recently saw a middle-aged man, a Hasidic Jew, with inflammatory bowel disease. He found that medical cannabis could be very helpful in controlling his IBD flares. In addition, when we were on a follow-up call a few months after he began taking medical cannabis, he asked me something.
“Dr. Weinberg,” he asked, “does THC give you wisdom?”
I was intrigued by the question and asked back, “Why, what do you mean?”
“Well,” he said, “I’ve been reading Talmud all my life, and there have always been passages I don’t understand.” He paused. “But when I take my medical cannabis, and I go back to my studies, I get it! I understand the meaning of those passages. And it’s not because I’m high! Both my wife and the rabbi agree that my insights are valid and profound.””
Clinical
In patients with temporomandibular disorders (problems with the jaw & oral muscles), CBD reduced pain, muscle tension & bruxism (night time grinding of the teeth)
Cannabidiol Intervention for Muscular Tension, Pain, and Sleep Bruxism Intensity-A Randomized, Double-Blind Clinical Trial
https://pubmed.ncbi.nlm.nih.gov/38592260/
In people with toothache, CBD an effective painkiller
Cannabidiol - an effective analgesic for toothache?
https://pubmed.ncbi.nlm.nih.gov/38649735/
For people with osteoarthritis, cannabis-based medicines improved their pain
Assessment of Clinical Outcomes in Patients With Osteoarthritis: Analysis From the UK Medical Cannabis Registry
https://pubmed.ncbi.nlm.nih.gov/38669060/
A survey of families using cannabis for their autistic children found a high adherence rate to treatment & substantial reported benefits
Characteristics for Medical Cannabis Treatment Adherence among Autistic Children and Their Families: A Mixed-Methods Analysis
https://karger.com/mca/article/doi/10.1159/000538901/906156/Characteristics-for-Medical-Cannabis-Treatment
In people with treatment-resistant epilepsy, adding artisanal CBD to their current treatment improved quality of life, decreased anxiety symptoms & reduced adverse events
An observational time-series study on the behavioral effects of adjunctive artisanal cannabidiol use by adults with treatment resistant epilepsies
https://pubmed.ncbi.nlm.nih.gov/38671370/
In people with spontaneous pneumothorax (a collapsed lung with air leaking into the chest cavity), cannabis users had shorter hospital stays, fewer complications & a lower risk of inhospitable mortality
Investigating the Impact of Cannabis Consumption on Hospital Outcomes in Patients With Primary Spontaneous Pneumothorax: A Nationwide Analysis
https://pubmed.ncbi.nlm.nih.gov/38586642/
In a human comparison of cannabis ingestion techniques, tablets & suppositories were lower than oromucosal sprays while vaporizers provided the highest concentration
Comparative Pharmacokinetic Assessment of Innovative Sublingual, Rectal and Vaporizer Cannabis Products Versus Approved Cannabis Products in Healthy Volunteers
https://pubmed.ncbi.nlm.nih.gov/38656906/
A case report of someone with REM-sleep behavior disorder who would get up & enact their (sometimes violent) dreams where treatment with melatonin made things worse but a cannabis gummy with 4.2 milligrams of THC resolved the problem completely
Alternative Treatment for REM-Sleep Behavior Disorder
https://academic.oup.com/sleep/article/47/Supplement_1/A503/7655228
In cats, an oral dose of 1:20 THC:CBD did not show adverse effects at 2 milligrams or 5 milligrams per kg & absorption was increased when given with a meal
Pharmacokinetic of two oral doses of a 1:20 THC:CBD cannabis herbal extract in cats
https://pubmed.ncbi.nlm.nih.gov/38585296/
Harms
In the human placenta, CBD disrupts metabolism of tryptophan, an essential amino acid for fetal neurodevelopment, leading to changes in serotonin & kynurenine levels
Cannabidiol disrupts tryptophan metabolism in the human term placenta
https://pubmed.ncbi.nlm.nih.gov/38663822/
A review of 27 studies on maternal vaping & the molecules & contaminants that pass into the fetus
Nicotine or marijuana vaping exposure during pregnancy and altered immune responses in offspring
https://f.oaes.cc/xmlpdf/1b610d6b-076e-4348-8f49-276ba0fe465c/jeea3003.pdf
In rat mothers, THC use led to more compromised maternal care & increased litter attrition
Perinatal Tetrahydrocannabinol Compromises Maternal Care and Increases Litter Attrition in the Long–Evans Rat
https://www.mdpi.com/2305-6304/12/5/311
A review of 42 studies on the lung & heart effects of cannabis broken down by routes of administration
Cardiovascular and Respiratory Effects of Cannabis Use by Route of Administration: A Systematic Review
https://pubmed.ncbi.nlm.nih.gov/38644600/
“Smoking was the most common route of administration and was associated with both respiratory effects, such as bronchitis, dyspnea, and chronic obstructive lung disease, and cardiovascular effects including tachycardia, ventricular arrhythmias, and myocardial infarction. Cannabis edibles were associated with minimal respiratory effects. Tachycardia [fast heart rate] was the most common cardiovascular effect and was associated with all routes of administration.”
A case report of a dab causing pneumonitis (lung tissue inflammation) with chest pressure & shortness of breath
Hot Dab Associated Pneumonitis - A Case Report
https://assets-eu.researchsquare.com/files/rs-4249247/v1/80772dc8-06d1-42a0-93ca-226ec29e363e.pdf?c=1714063553
Reviews
For fibromyalgia symptoms, a review of the evidence for medical cannabis
Is Medical Cannabis a Solution for Controlling Fibromyalgia Symptoms?
https://pubmed.ncbi.nlm.nih.gov/38569807/
A review of using hemp extracts against arthritis & diabetes
Tapping the nutraceutical potential of industrial hemp against arthritis and diabetes - A comprehensive review
https://www.sciencedirect.com/science/article/abs/pii/S2212429224006254
For opioid use disorder, a review of treating it with medical cannabis
The Role of Medicinal Cannabis as an Emerging Therapy for Opioid Use Disorder
https://pubmed.ncbi.nlm.nih.gov/38676910/
A big beautiful review of how the cannabinoids cause neuromodulation via many networks
Phytocannabinoids in neuromodulation: From omics to epigenetics
https://pubmed.ncbi.nlm.nih.gov/38677573/
On the cannabinoids & liver enzymes, a review of seven studies on how THC & CBD change the activity of several CYP450 enzymes
Effects of cannabidiol and Δ9-tetrahydrocannabinol on cytochrome P450 enzymes: a systematic review
https://pubmed.ncbi.nlm.nih.gov/38655747/
“Results from the included studies indicate that both CBD and THC inhibit several CYP450 enzymes including, but not limited to, CYP1A2, CYP3C19, and CYP2B6.”
It’s hard to believe that there’s so few studies on such an important research area.
Medical cannabis laws linked to fewer reported days of poor mental health, especially for those who suffer from frequent pain
Medical marijuana laws and mental health in the United States
https://pubmed.ncbi.nlm.nih.gov/38562089/
A wide-ranging review of the antimicrobial & anti-pathogenic properties of cannabis
Evaluating the Metabolomic Profile and Anti-Pathogenic Properties of Cannabis Species
https://www.mdpi.com/2218-1989/14/5/253
A review of the strong signaling differences between CB1 receptors on the cell’s outer membrane versus its internal membranes
Cannabinoid Receptor Signaling is Dependent on Sub-Cellular Location
https://pubmed.ncbi.nlm.nih.gov/38562854/
Preclinical
An analysis finds the cannabinoid content of cannabis tea to be quite variable
Cannabinoid variability in cannabis tea: A comparative analysis of Danish medicinal cannabis products and brewing techniques
https://portal.findresearcher.sdu.dk/en/publications/cannabinoid-variability-in-cannabis-tea-a-comparative-analysis-of
In a rat model of depression, CBD improved neuroinflammation & modulated gene expression (including estrogen) with some differences between the genders
Differential Learned Helplessness Phenotypes in Male and Female Rats: Exploring the Therapeutic Impact of Cannabidiol Treatment
https://assets-eu.researchsquare.com/files/rs-4270261/v1/2a25cbdd-f497-49aa-b9ea-d02a12ecb367.pdf?c=1713884565
In a mouse model of Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD – a loss-of-function genetic mutation leading to early epilepsy, autism, motor impairment & severe intellectual disability), CBD lessened the susceptibility to seizures via changes in CB1, TRPV1 & TRPV2 receptors in the hippocampus & cortex
Cannabidiol attenuates seizure susceptibility and behavioural deficits in adult CDKL5R59X knock-in mice
https://pubmed.ncbi.nlm.nih.gov/38654472/
In a mouse model of PTSD, CBD alleviated their PTSD-like behaviors via changes to the expression of over 60 genes
Single-Nucleus Transcriptome Profiling from the Hippocampus of a PTSD Mouse Model and CBD-Treated Cohorts
https://pubmed.ncbi.nlm.nih.gov/38674453/
“A total of 63 overlapping genes in InNs were identified as key genes for CBD in the treatment of PTSD. Subsequent Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed that the anti-PTSD effect of CBD was related to the regulation of protein synthesis, oxidative phosphorylation, oxidative stress response, and fear response.”
In a mouse model of cocaine use disorder, CBD reduced interest in cocaine & improved the lost gut microbial diversity
Cannabidiol (CBD) facilitates cocaine extinction and ameliorates cocaine-induced changes to the gut microbiome in male C57BL/6JArc mice
https://pubmed.ncbi.nlm.nih.gov/38649130/
In a rat model of treatment-resistant depression, CBDA methyl ester (a stable version of CBDA) improved depressive behaviors & related molecular factors
Unraveling the molecular basis of cannabidiolic acid methyl Ester's anti-depressive effects in a rat model of treatment-resistant depression
https://pubmed.ncbi.nlm.nih.gov/38704981/
In a rat safety study of oleoylethanolamide, large acute doses or chronic administration cause no significant adverse alterations except for increased liver weight & ALT levels
A Comprehensive Safety Profile of Oleoylethanolamide
https://www.scivisionpub.com/pdfs/a-comprehensive-safety-profile-of-oleoylethanolamide-3241.pdf
“Based on the above results, OEA is considered to be safe up to dosage at 2500 mg/kg b.wt./day body weight and can be further developed for future applications.”
In rats trained to distinguish THC (or CB1 activating drugs), they did not respond to terpenes alone & when those terpenes were combined with THC, they did not enhance its potency (and α-humulene even decreased the THC’s potency)
Discriminative stimulus properties of Cannabis sativa terpenes in rats
https://pubmed.ncbi.nlm.nih.gov/38660819/
CBD found to be the first FDA-approved drug to potentiate the HCN4 cardiac pacemaker channels
Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide-gated (HCN4) channels
https://pubmed.ncbi.nlm.nih.gov/38652080/
On how the policosanols (long-chain alcohols extracted from plant waxes, often used a dietary supplement) of cannabis caused anti-inflammatory & antioxidant effects
Extraction, purification and in vitro assessment of the antioxidant and anti-inflammatory activity of policosanols from non-psychoactive Cannabis sativa L
https://pubmed.ncbi.nlm.nih.gov/38737258/
An evergreen note on reading restricted papers:
First stop for seeing if there’s a free version of a paper, use the Google Scholar Chrome extension (Mac version), Google Scholar itself or try ResearchGate.
Three other helpful browser extensions are: Unpaywall, Open Access Button & PaperPanda
For the infamous backdoor, use Sci-Hub – the pirated papers repository (Chrome extension here). This works better for older paper than the stuff that just came out.
Finally, email the author. They’re almost always happy to oblige because, thanks to the predatory academic publishing system, they don’t make a dollar off of their papers.
the Headlines & Fav Articles
US hemp industry pushing back against cannabis companies advocating for the new Farm Bill to ban all intoxicating cannabinoids from hemp
https://www.marijuanamoment.net/hemp-industry-pushes-back-against-marijuana-companies-advocating-for-intoxicating-cannabinoid-ban-in-farm-bill/
While the aim is to stop things delta-8 THC products, this move would also make the majority of hemp extracts illegal too because of their low levels of delta-9 THC.
Quest Diagnostics reports that the number of drug tests that show signs of tampering has gone up 6X since the year before
https://www.prnewswire.com/news-releases/workforce-drug-test-cheating-surged-in-2023-finds-quest-diagnostics-drug-testing-index-analysis-of-nearly-10-million-drug-tests-302146317.html
Cannabis hero Alice O'Leary Randall the latest to be stricken by those cowardly censorious assholes at Stripe
International
In Germany, a poll found that 7% of people already bought cannabis seeds for home grows & and other 11% plan to
https://yougov.de/topics/politics/survey-results/daily/2024/05/13/d2f5a/2
and Germany releases 125 prisoners who were in for cannabis
https://www.tagesschau.de/inland/cannabis-haftentlassungen-100.html
The Laws, The War on Drugs & the End of Prohibition
An analysis of how Mexican cartels are really partners of the governmental elites
Former DEA officer pleads guilty to stealing over 1000 lbs of cannabis from evidence
https://www.justice.gov/usao-mdfl/pr/former-deputy-sheriff-and-dea-task-force-officer-pleads-guilty-conspiring-distribute
In young adults in Washington, the opening of cannabis retail stores led to a decrease of drunk driving, no change in cannabis driving & a decrease in driving on both substances
Young Adult Alcohol and Cannabis Impaired Driving After the Opening of Cannabis Retail Stores in Washington State
https://pubmed.ncbi.nlm.nih.gov/38664365/
In Croatia, how law enforcement distinguishes between cannabis & hemp
An Overview of Cannabis Seizures and Methods for Distinguishing Between Cannabis and Hemp in Croatia
https://www.croris.hr/crosbi/publikacija/prilog-skup/827468
Psychedelics, Plant Medicines & Other Psychoactives
RIP Ken Jordan
https://www.lucid.news/lucid-news-salutes-our-friend-ken-jordan/
We did a lot of events together in NYC. He was a standup guy who was doing good work for the community. He will be missed. My condolences go out to his family.
On the extended difficulties that can happen from MDMA
A new takedown piece on MAPS
https://www.businessinsider.com/mdma-therapy-maps-lykos-rick-doblin-fda-legalization-trials-2024-5
A review of ‘Blotter: The Untold Story of an Acid Medium’ by friend of the newsletter Erik Davis
On the coming inequality of psychedelic therapy
https://www.thenation.com/article/society/psychedelics-mdma-ketamine-access-inequality/
The Psychoactive Research
On the need for innovative postmarket surveillance for psychedelics
Optimizing real-world benefit and risk of new psychedelic medications: the need for innovative postmarket surveillance
https://www.nature.com/articles/s44220-024-00233-1
Psilocybin did not make atheists believe more in God but it did make believe more in spirits living in animals, plants & rocks
Psychedelic Experiences Increase Mind Perception but do not Change Atheist-Believer Status: A Prospective Longitudinal Study
https://pubmed.ncbi.nlm.nih.gov/38715376/
The Plant & the History
Growing, Farming & Processing
A review on managing pathogens & microbes in your greenhouse grows
Integrated Management of Pathogens and Microbes in Cannabis sativa L. (Cannabis) under Greenhouse Conditions
https://pubmed.ncbi.nlm.nih.gov/38592798/
On how supercritical CO2 carboxylates & decarboxylates between CBDA & CBD
Direct de/carboxylation of cannabidiolic acid (CBDA) and cannabidiol (CBD) from hemp plant material under supercritical CO2
https://pubmed.ncbi.nlm.nih.gov/38676379/
In a study of the time of day altering metabolite content, while the cannabinoid levels increased over the day, their key biosynthetic enzymes decreased along with the levels of sesquiterpenes & the monoterpene α-pinene
From dawn ‘til dusk: daytime progression regulates primary and secondary metabolism in Cannabis glandular trichomes
https://academic.oup.com/jxb/advance-article-abstract/doi/10.1093/jxb/erae148/7659228?redirectedFrom=fulltext
On evidence for using the biostimulants silicate & phosphite
Bioaccumulation of silicon and enhancement of cannabis inflorescence yield from fertilizer supplementation with the biostimulants silicate and phosphite
https://www.tandfonline.com/doi/pdf/10.1080/01140671.2024.2339494
In hemp seedlings damaged by salt, healing with phytohormones (abscisic acid (ABA), salicylic acid (SA), gibberellin A3 (GA3), α-naphthalene acetic acid)
Exogenous Application of Phytohormones Alleviates Salt Injury to Growth, Physiological, and Biochemical Attributes of Hemp Seedlings
https://link.springer.com/article/10.1007/s00344-024-11278-y
How the plant microbiome varies by hemp cultivar in commercially sourced seed
Bacterial endophytic community composition varies by hemp cultivar in commercially sourced seed
https://pubmed.ncbi.nlm.nih.gov/38649235/
An optimized protocol for measuring transient gene expression & promoter activity in cannabis
Quantitative Estimation of Promoter Activity in Cannabis sativa Using Agroinfiltration-Based Transient Gene Expression
https://pubmed.ncbi.nlm.nih.gov/38656494/
Analysis of the expression of the ascorbate peroxidase enzyme (APX) in response to stresses such as drought
Genome-wide identification and analysis of ascorbate peroxidase (APX) gene family in hemp (Cannabis sativa L.) under various abiotic stresses
https://pubmed.ncbi.nlm.nih.gov/38685943/
A review of hemp as a sustainable carbon negative plant
Hemp as A Sustainable Carbon Negative Plant: A Review of Its Properties, Applications, Challenges and Future Directions
https://publisher.uthm.edu.my/ojs/index.php/ijie/article/view/14699
Food & Nutrition
A review of hemp seeds as a food
Hemp (Cannabis sativa L.) seeds nutritional aspects and food production perspectives: A review
https://www.fsjour.com/jour/article/view/411
Industrial Use
How to enhance hemp fiber performance with chitosan treatment
Enhancing hemp fiber performance: insights into chitosan treatment and structural evolution
https://journals.sagepub.com/doi/abs/10.1177/00405175241240153
CANNABINOID SCIENCE
Some songbirds will only eat hemp seeds if given the chance
Seed preference is only weakly linked to seed-type-specific feeding performance in a songbird
https://pubmed.ncbi.nlm.nih.gov/38602456/
Fun fakt: Over the last centuries, one of the most reported benefits from bird fanciers is that hemp seeds make them more amorous.
Public Health
Hair tests in mothers & children show shifting endocannabinoid levels
Stability and inter-family associations of hair endocannabinoid and N-acylethanolamines across the perinatal period in mothers, fathers, and children
https://pubmed.ncbi.nlm.nih.gov/38658668/
Adolescents & Young Adults
On the messy data between violence & cannabis use in young adults
Associations of cannabis use, use frequency, and cannabis use disorder with violent behavior among young adults in the United States
https://pubmed.ncbi.nlm.nih.gov/38677161/
A survey of doctors in California found that they thought adult-use cannabis laws led to increased harms among adolescents because of increased parental permissiveness & a decreased perception of harm
Clinician perspectives on adolescent cannabis-related beliefs and behaviors following recreational cannabis legalization
https://www.sciencedirect.com/science/article/abs/pii/S0306460324000959
In young adults with psychosis, a study of their preferred cannabis-focused harm reduction interventions
Preferences of Young Adults With Psychosis for Cannabis-Focused Harm Reduction Interventions: A Cross-Sectional Study: Préférences des jeunes adultes souffrant de psychose pour les interventions de réduction des méfaits axées sur le cannabis : une étude transversal
https://pubmed.ncbi.nlm.nih.gov/38571478/
In young adults, the greater number of past six month cannabis use episodes was related to poor emotional accuracy & working memory
Investigating sex differences and age of onset in emotion regulation, executive functioning, and cannabis use in adolescents and young adults
https://pubmed.ncbi.nlm.nih.gov/38671541/
In young adults, they reported more negative consequences on days where they simultaneously used alcohol & cannabis than they did when using each of them alone
Interactive effects of alcohol and cannabis quantities in the prediction of same-day negative consequences among young adults
https://pubmed.ncbi.nlm.nih.gov/38575530/
Using clinical AI to reduce cannabis-related harms in young adults
Exploring Algorithmic Explainability: Generating Explainable AI Insights for Personalized Clinical Decision Support Focused on Cannabis Intoxication in Young Adults
https://arxiv.org/pdf/2404.14563
In adolescents, a review of studies found nicotine to be a predictor of cannabis use
Nicotine and Alcohol Use as Predictors of Recreational Cannabis Use in Adolescence: A Systematic Review and Narrative Synthesis
https://pubmed.ncbi.nlm.nih.gov/38658323/
The Brain
In a rat model of Parkinson's disease, activating the CB2 receptor delayed immune cell infiltration into the brain, decreased pro-inflammatory white blood cells & elevated wound healing white blood cells & wound-healing gene expression
Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy
https://pubmed.ncbi.nlm.nih.gov/38562842/
In the prefrontal cortex, the ability of neurons to undergo long-term depression (a crucial feature of synaptic plasticity) is mediated by CB1 receptors modulating excitatory amino acid transporters in the astroglia (brain immune cells)
Modulation of Astroglial Glutamate Transporters by CB1 Receptor Shapes Endocannabinoid-Mediated Long-Term Depression in the Medial Prefrontal Cortex
https://assets-eu.researchsquare.com/files/rs-4281560/v1/271eb903-c728-4846-99d9-ed4be2dec98e.pdf?c=1713552857
When ketamine causes neuroprotection from glutamate toxicity, it does so via the CB1 receptor
CB1 receptor mediates anesthetic drug ketamine‑induced neuroprotection against glutamate in HT22 cells
https://pubmed.ncbi.nlm.nih.gov/38756904/
Mental Health & Substance Use Disorders
In South London, the role of cannabis in the increased incidence of psychosis during COVID is... behind a paywall
The increased incidence of psychosis during the COVID-19 pandemic in South London: The role of heavy cannabis use
https://pubmed.ncbi.nlm.nih.gov/38583244/
The genetic influences & pathways of cannabis use disorder shared similarities with other psychoactive use disorders
Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits
https://pubmed.ncbi.nlm.nih.gov/38580809/
On legalization & mental health, a review of 28 studies found a paucity research & largely inconclusive results
Effects of Recreational Cannabis Legalization on Mental Health: Scoping Review
https://pubmed.ncbi.nlm.nih.gov/38650490/
A review finds cannabis use linked to depression
Herbal Cannabis and Depression: A Review of Findings Published over the Last Three Years
https://www.researchgate.net/publication/380195809_Herbal_Cannabis_and_Depression_A_Review_of_Findings_Published_over_the_Last_Three_Years
In a rat model of heroin use disorder, rimonabant (a blocker of CB1) reduced heroin cue-induced heroin-seeking behavior for a month
Interfering with reconsolidation by rimonabant results in blockade of heroin-associated memory
https://pubmed.ncbi.nlm.nih.gov/38576487/
In a mouse model of oxycodone withdrawal, a drug that acts as a negative allosteric modulator of the CB1 receptor (also a function of CBD) reduced anxiety symptoms but caused locomotor & GI motility effects
Effects of CB1 receptor negative allosteric modulator Org27569 on oxycodone withdrawal symptoms in mice
https://pubmed.ncbi.nlm.nih.gov/38676755/
Immune System & Autoimmune Disorders
In a mouse model of HIV associated neurocognitive disorder, a drug that inhibits the MAGL enzyme (which breaks down 2AG) protected against dendritic injury & caused anti-inflammatory & neuroprotective effects
A helping HAND: therapeutic potential of MAGL inhibition against HIV-1-associated neuroinflammation
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1374301/full
In a mouse model of graft versus host disease, the CB2 receptors on microglial cells (guardian immune cells of the brain) caused inflammation that was reduced with a CB2 inverse agonist/antagonist
Type 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft versus host disease
https://pubmed.ncbi.nlm.nih.gov/38662453/
Hormones & Reproduction
In pregnant female rats, treatment with oleoylethanolamide for the entire pregnancy gained less weight during the pregnancy but no other abnormalities in pregnancy or offspring
Pre-Natal Developmental Toxicity of Oleoylethanolamide (OEA)
https://www.scivisionpub.com/pdfs/prenatal-developmental-toxicity-of-oleoylethanolamide-oea-3240.pdf
Musculoskeletal & Exercise
In athletes, six days of CBD oil improved some immune parameters but did not change performance
Influence of short-term chronic oral cannabidiol application on muscle recovery and performance after an intensive training protocol - a randomized double-blind crossover study
https://pubmed.ncbi.nlm.nih.gov/38572744/
In a mouse model of cachexia (muscle degeneration, often found in cancer), those with the muscle loss had lower levels of endocannabinoid machinery
Endocannabinoid remodeling in murine cachexic muscle associates with catabolic and metabolic regulation
https://pubmed.ncbi.nlm.nih.gov/38653357/
The Heart
The trends of cannabis use among heart attack patients
Prevalence of cannabis consumption among acute myocardial infarction patients across various age categories over a two-decade span in the United States
https://pubmed.ncbi.nlm.nih.gov/38556143/
The Lungs
In a mouse model of allergic asthma, blocking the CB1 receptor reduced the airway’s hyperresponsiveness & inflammation as well as showing immunomodulatory effects
The Role of Cannabinoid-1 Receptor Ligands in the Ovalbumin-Induced Mouse Model of Allergic Asthma: Is It Related to Transient Receptor Potential Vanilloid-1 Channels?
https://pubmed.ncbi.nlm.nih.gov/38656908/
The Eye
In a mouse model of a detached retina & proliferative vitreoretinopathy (inflammation & microglial immune cell proliferation), activating the CB2 receptor lowered inflammation & retinal pathology
Enantiomeric Agonists of the Type 2 Cannabinoid Receptor Reduce Retinal Damage during Proliferative Vitreoretinopathy and Inhibit Hyperactive Microglia In Vitro
https://pubmed.ncbi.nlm.nih.gov/38751621/
The Skin
Printing a 3D cannabinoid microneedle patch & testing it in rats
3D DLP-printed cannabinoid microneedles patch and its pharmacokinetic evaluation in rats
https://pubmed.ncbi.nlm.nih.gov/38656627/
Creating a new CBD topical from Sambucus ebulus fruit
Development and Characterization of a Microemulsion Con-taining a Cannabidiol Oil and a Hydrophilic Extract from Sambucus ebulus for Topical Administration
https://www.preprints.org/manuscript/202404.1772/v1
Synthetic Cannabinoids
How HHC activates the CB1 receptor versus THC
Hexahydrocannabinol (HHC) and Δ9-tetrahydrocannabinol (Δ9-THC) driven activation of cannabinoid receptor 1 results in biased intracellular signaling
https://pubmed.ncbi.nlm.nih.gov/38649680/
Cool Chemistry & Tools
A kit to check the blood levels of 24 cannabinoids & their metabolites
Cross-Reactivity of 24 Cannabinoids and Metabolites in blood using the immunalysis cannabinoids direct enzyme-linked immunosorbent assay kit
https://pubmed.ncbi.nlm.nih.gov/38648393/
A review of the recent changes to the analytical tools for cannabinoid content analysis
Progress in the analysis of phytocannabinoids by HPLC and UPLC (or UHPLC) during 2020-2023
https://researchonline.ljmu.ac.uk/id/eprint/23142/
New amorphous CBD formulations to increase bioavailability
Evaluation of amorphous and lipid-based formulation strategies to increase the in vivo cannabidiol bioavailability in piglets
https://www.sciencedirect.com/science/article/abs/pii/S0378517324004071
A tool for sampling the smoke from cannabis cigarettes for analysis
An Automated “Hands-Off” Method for Sampling Mainstream Smoke from Cannabis Cigarettes
https://www.mdpi.com/2305-6304/12/5/313
Thanks.
- lex
PS: Today’s Cuban jazz album comes from the Bebo Valdés Trío: ‘El Arte del Sabor’ (the Art of Flavor). A central figure in the golden age of Cuban music in the middle of the last century, Valdés went into a musical hiatus after going into exile after the Cuban Revolution. He began producing music again in 1994 with the album ‘Bebo Rides Again’ while the Latin jazz documentary ‘Calle 54’ got his piano playing before a wider audience. He recorded several more well-received albums before his death in 2013. This is his third album from that period & it won the 2002 Latin Grammy Award for Best Traditional Tropical Album.
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