4th Birthday! + Survey! + Glow-up! + cannabis for exercise, dizziness & early human history
Medicare to cover CBD
Cannabinoids & The People,
or; Drugs & Drug Wars
🌟 This week 🌟
CBD for exercise-induced muscle injury
Cannabis helping with dizziness
Topical CBD gel for genetic neurodevelopmental disorder
Cannabis intoxication not helpful for identifying someone in a police lineup
Cardiotoxicity: see the ‘Heart’ section for reports from this year’s American College of Cardiology conference (alert: lousy puns ahead)
Preclinical: prenatal CBD exposure linked to more hyperactivity as adolescents
Evidence of cannabis use in China 4500 years ago
Psychedelics: intranasal 5-MeO-DMT for depression + mescaline for mental health
Winner for the best mobile harm reduction program name: Spike on a Bike
(this week’s numbers: ~6.8k words, ~18 minutes reading time, 122 papers)
📌 Editor’s notes 📌:
It’s the 4th anniversary of ‘Cannabinoids & the People’ on Substack. Now, the traditional gift for the 4th anniversary is fruit & flowers, but the modern gift is electrical appliances. So what I want more than anything in the world is an electric vegetable slicer.
In celebration, I did a re-formatting of this newsletter to make it more accessible for you & after a meeting with the social media maven Rachel Colic (highly recommended), I’m going to focus more this year on building up my YouTube channel with longer, horizontal videos filmed against the backdrop of my office. The deeper dives suit my style & I’m looking forward to experimenting more on covering topics close to my heart, such as this one on making all drugs illegal.
Survey:
(you can just reply to this email if you’re reading from Substack, or DM me on LinkedIn. And partial answers are more helpful than no answers. I’m just trying to make this newsletter as useful as possible)
For my questions, the main one is: What’s helpful about this newsletter to you & how do you use it?
- Does anything bug you about it? Especially user interface. I’m trying to make it as easy to quickly parse as I possibly can, while still being my completionist self.
- Are there any areas of coverage related to these that you’d like to hear more on?
- Would hashtags help in the “This Week” section at the top so you can quickly find the article referenced below?
Thanks.
I appreciate all of you following along with this unwieldy whale of a newsletter. I feel lucky that I get to put it together, set it adrift each week & let it land where it might. Around 2,000 of you open it each week & at least run your eye down it. There might even be some obsessive soul out there who goes through each issue cover to cover. And I wanted to say to all of you, thanks for reading it & making it worth it.
Hello everyone,
Welcome to the 183rd edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news as well as the War on Drugs, harm reduction & other psychoactives. Support this work with a paid subscription or by buying me a coffee.
If you purchase one of my canna-graphic novels based on Moby Dick, proceeds go to Americans for Safe Access to support medical cannabis patients.
For producing cannabinoid content, work with my company White Whale Creations: writing, science archives, social media, newsletters & podcasts.
As always, ask me anything!
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🎥 Lex’s new work 🎤
@CannabinoidsAndThePeople on YouTube, TikTok & LinkedIn
Canna-edu videos sponsored the National Cannabis Study (join & get paid $100 to talk about your use of our favorite plant)
All drugs illegal? On the deep racism of the US War on Drugs (my audio could be better, but this one is close to my heart)
That notorious review on cannabis & mental health (hattip to Dr. Uwe Blesching of CannaKeys)
Canna-science Videos for CV Sciences on YT @CVSciencesInc & on TT @pluscbd
For 30% off their CBD, THC & PEA products, at pluscbdoil.com use the coupon code ‘LEX’
@LexPelgerAndHisBooks on TikTok, YouTube & Instagram:
And as always, at the bottom is the album of the week: a life of Delta blues
💖 Ways to support this work 💖
- A paid subscription on Substack
- Venmo: @Lex-Pelger
- PayPal: donate here
📣 A request to spread the word 📣
This newsletter only spreads by word of mouth, so please share to friends & colleagues.
🍃 BEST OF CANNABINOID SCIENCE 🍃
(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)
⚕️ Clinical ⚕️
In people with exercise-induced muscle injury, CBD caused less peak pain at rest & with movement as well as less strength impairment & physical disability
Efficacy and safety of cannabidiol (CBD) on reducing pain and functional impairment associated with exercise-induced muscle injury: a randomized placebo-controlled feasibility trial
https://link.springer.com/article/10.1186/s42238-026-00431-x
But for muscle recovery after damage from exercise, a CBD topical did not accelerate recovery or lower soreness
Topical application of cannabidiol for muscle recovery after exercise-induced muscle damage: a randomized, double-blinded pilot study
https://link.springer.com/article/10.1186/s42238-026-00420-0
In people with kidney failure, interviews on the improvements from CBD
WCN26-3667 PATIENT EXPERIENCES WITH CANNABIDIOL FOR SYMPTOM MANAGEMENT IN KIDNEY FAILURE: QUALITATIVE INSIGHTS FROM THE SEISMIC-CBD TRIAL
https://www.kireports.org/article/S2468-0249(26)00342-6/pdf
And on the pharmacokinetics of CBD moving through their system
WCN26-5407 PHARMACOKINETICS OF CANNABIDIOL IN PEOPLE WITH KIDNEY FAILURE: FINDINGS FROM THE SEISMIC-CBD TRIAL
https://www.kireports.org/article/S2468-0249(26)00352-9/fulltext
In people experiencing dizziness, a survey found the majority willing to consider cannabis & 20% reported cannabis to cause a moderate to large subjective relief
A Cross-Sectional Survey of Cannabis Use and Utility Among Patients Experiencing Dizziness
https://www.mdpi.com/2076-3425/16/4/360
In children with 22q11.2 deletion syndrome (a genetic disease of developmental delays & a range of potential effects), a topical CBD gel caused improvements on all measures, including disease severity, anxiety, behavior & caregiver reported effects
Phase 2, open-label INSPIRE trial to assess the tolerability and effectiveness of transdermal cannabidiol gel in children and adolescents with 22q11.2 deletion syndrome (ZYN2-CL-031)
https://link.springer.com/article/10.1186/s11689-026-09687-z
In people with chronic neuropathic pain, capsules of 1:1 THC:CBD caused substantial pain reductions & improved health-related quality of life in physical & social functioning, energy/fatigue & emotional well-being
Analgesic and Quality of Life Effects of 1:1 Delta-9-Tetrahydrocannabinol: Cannabidiol Oral Formulation on Chronic Neuropathic Pain Subjects During a Four-Week Observation Period: Pilot Study
https://www.jpain.org/article/S1526-5900(25)01097-1/abstract
In people with anorexia nervosa, CBD was well tolerated & caused small increases in body mass index
Cannabidiol in Anorexia Nervosa: A Double-Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change
https://pubmed.ncbi.nlm.nih.gov/41906184/
In a case report of someone with geographic tongue (inflammatory patches of missing papillae on the tongue), full-spectrum CBD oil caused significant improvements to oral pain
Full Spectrum Cannabidiol Oil as a Symptomatic Management Strategy in Geographic Tongue: Case Report with Literature Review
https://www.bjcasereports.com.br.editorapcaa.com.br/index.php/bjcr/article/view/bjcr179
When giving CBD to fed or fasting dogs, an analysis of their fecal excretions found better bioavailability when fed
Comparative plasma exposure and fecal excretion of oral cannabidiol in fasted and fed dogs: pilot study
https://link.springer.com/article/10.1007/s11259-026-11170-y
📑 Reviews 📑
On CBD for developmental epilepsy, a review of the mechanisms (with nice charts)
Cannabidiol in Developmental Epilepsy: Organoid-Guided Precision Medicine Across Critical Neurodevelopmental Windows
https://www.mdpi.com/1422-0067/27/6/2899
⚠️ Harms ⚠️
For neurocognitive recovery after cannabis use disorder, a review of 26 studies found cognitive improvements within the first week of cessation & CB1 receptor normalization within a month
Cannabis cessation and neurocognitive recovery: Patterns, predictors, and clinical implications-a systematic review
https://pubmed.ncbi.nlm.nih.gov/41872072/
In people with cannabis-induced first episode psychosis, hopelessness & depression independently predicted psychotic severity
The role of hopelessness and depression in cannabis-induced first-episode psychosis: a 24-month prospective study
https://www.sciencedirect.com/science/article/abs/pii/S0306460326001097
In people with cannabis use disorder, case reports where stellate ganglion blocks (anesthetic injection into nerves of the neck) caused reduced withdrawal symptoms
Stellate Ganglion Block for the Management of Cannabis Use Disorder: A Case Series
https://assets.cureus.com/uploads/case_report/pdf/473445/20260326-306793-2mehor.pdf
In an adolescent rat model of vaped THC exposure, early abstinence impaired their memory performance but this was rescued by citicoline (a brain chemical & dietary supplement)
Prior cannabis vapor exposure impairs pattern separation in rodents of multiple ages but is rescued by citicoline administration
https://www.sciencedirect.com/science/article/pii/S0306452226002101
In a rat model of prenatal CBD exposure, the litter size was reduced & as adolescents, they were more hyperactive & in females, more risk-taking
Prenatal cannabidiol exposure alters physical and behavioral development in rats
https://www.sciencedirect.com/science/article/abs/pii/S0892036226000164
🐁 Preclinical 🐁
In a mouse model of Parkinson’s disease, both CBD & THC individually & in combination caused antidepressant-like effects & significantly elevated brain dopamine levels
Antidepressant-like Effects of Cannabidiol and Tetrahydrocannabinol in a Reserpine-induced Mouse Model of Parkinson’s Disease
https://hal.science/hal-05570890/
In a mouse model of acute lung injury, CBD reduced inflammation & suppressed the immune system response of neutrophils & macrophages
Cannabidiol hinders lipopolysaccharide-induced neutrophils migration to the lungs through suppressing nuclear factor kappa-B signal and expression of interleukin-1 beta in macrophages
https://www.sciencedirect.com/science/article/abs/pii/S0944711326003570
In a rat model of inflammation, CBD-rich cannabis extracts not only failed to inhibit the inflammatory response but may have even exacerbated it
Evaluation of Anti-Inflammatory Effects of Cannabis sativa Extracts via Possible Modulation of mRNA Levels of Inflammatory Cytokines and Cannabinoid Receptors
https://www.mdpi.com/2072-6643/18/7/1106
In a rat model of orofacial neuropathic pain, CBD, CBG & full-spectrum extract all worked in females, but males responded only to the CBG & full-spectrum extract
Cannabinoid Modulation and Sex Differences in Orofacial Neuropathic Pain
https://www.jpain.org/article/S1526-5900(25)01339-2/abstract
In a rat model of neuropathic pain & a tolerance to opioids, CBD reduced their mechanical hypersensitivity & partially counteracted the metabolic dysregulation
Cannabidiol (CBD) modulates the serotonin–kynurenine metabolic balance in the brain of morphine-tolerant neuropathic rats
https://link.springer.com/article/10.1007/s43440-026-00850-w
In mice taking oxycodone, CBD inhibited the breakdown of oxycodone, increased exposure by 3X & extended painkiller efficacy, possibly mediated by the liver enzymes CYP2D6 & CYP3A4
Behavioural, pharmacokinetic, and genetic evidence of a cannabidiol-oxycodone drug-drug interaction in mice
https://www.sciencedirect.com/science/article/pii/S0753332226003100
In a rat model of phantom limb pain, given prophylactically, either THC or CBD+ beta caryophyllene reduced onset & severity, while with delayed treatment, the most effective were CBD+THC+ beta caryophyllene or CBD+ beta caryophyllene, working via GABA (the brain’s most common inhibitory neurotransmitter) in the spinal cord
Targeting Phantom Limb Pain with Cannabinoids in a Rat Model
https://karger.com/mca/article-pdf/doi/10.1159/000551763/4522754/000551763.pdf
In a rat model of cerebral ischemia-reperfusion injury (blood flowing back into the brain after a block), the terpene beta caryophyllene caused neuroprotection
High-Throughput RNA Sequencing Identifies Hub Genes and Anti-inflammatory Effects of β-Caryophyllene in Cerebral Ischemia-Reperfusion via p38MAPK/NF-κB Modulation
https://www.sciencedirect.com/science/article/pii/S0361923026001437
In a fruit fly model of ALS, on the benefits from both a mixture of flavonoids + terpenes as well as Cannaflavin A
Transcriptomic Effects of Cannabis-Derived Therapies in a Drosophila model of ALS
https://storage.prod.researchhub.com/uploads/papers/users/79414/f704d059-6796-43a1-af55-c5bf3e0bea06/Drosophila%20Manuscript%20-%20Canurta%2012-03-2026.pdf
In a rat model of exercise helping depression, running improved the levels of CB1 receptors in an area of the prefrontal cortex, which was associated with improved behavior
Medial prefrontal cortical CB1Rs and astrocytes are involved in depression and the antidepressant effects of running exercise in male rats
https://www.sciencedirect.com/science/article/abs/pii/S016503272600546X
🆕 Novel Studies 🆕
(a grab bag section for cool & new stuff)
In northern China, the first identification of cannabis phytoliths (plant fossils) from 4500 years ago with evidence that the plant was well integrated into local agricultural economy
Integrating cannabis into the prehistoric crop assemblage: Phytolith evidence from Shandong, Northern China (4500-3400 BP)
https://www.sciencedirect.com/science/article/abs/pii/S0305440326000750
For eyewitness testimony watching a mock crime, cannabis users did not differ for memory performance, but intoxication caused inflated confidence when making errors in identifying someone in a lineup
Cannabis intoxication does not impair eyewitness recall with the Sketch Cognitive Interview but increases confidence in lineup errors
https://www.nature.com/articles/s41598-026-45069-0_reference.pdf
In the US since 2010, adolescents referred to cannabis treatment programs by the criminal legal system decreased substantially
Decreasing criminal legal system referrals to cannabis treatment in the US: Adolescent trends by race and ethnicity between 2010-2022
https://www.sciencedirect.com/science/article/pii/S0749379726000942
[AI policy analysis] For states with automatic cannabis record expungement, this raised average monthly Black earnings by 6.8% & White earnings by 3.9%
The Expungement Dividend: Automatic Marijuana Record Clearing and Black Labor Market Outcomes
https://ape.socialcatalystlab.org/papers/apep_0714/v1/paper.pdf
I’ve never seen this before, but apparently this paper from the Autonomous Policy Evaluation Project is part of their effort to create automated policy evaluations. I don’t know if you can trust it, but I’m glad to know it exists.
Lex’s roundup of fav newsletters:
#Canna: Marijuana Moment, Cannabis Law Report, Cultivated, Cannabis Musings (oy vey), Talking Joints Memo, Sticky Bits, Highly Objective, Cannabitch, Indigenous Cannabis Industry Association, Dr. Peter Grinspoon, Doctor Approved, Medical Marijuana Memory Blog (by Dame Alice O’Leary Randall)
#DrugWar: InSight Crime, Marshall Project, Students for Sensible Drug Policy
#HarmReduction: Filter, Drug Data Decoded, International Drug Policy Consortium, National Harm Reduction Coalition, Canadian Drug Policy Coalition
#Psychoactives: Psychedelic Alpha, Ecstatic Integration, ICEERS, Substance, The Microdose
📰 US Headlines & Fav Articles
Medicare & Medicaid Services (CMS) announced their plan to cover up to $500 worth of hemp-derived products each year for eligible patients
https://www.marijuanamoment.net/dr-oz-announces-launch-of-program-covering-hemp-thc-and-cbd-products-through-medicare/
And the head of the FDA quickly said they won’t enforce the CBD laws against this program (because it clearly contravenes them)
https://www.marijuanamoment.net/new-fda-enforcement-memo-clears-way-for-hemp-cbd-product-coverage-under-new-medicare-plan/
And a lawsuit by anti-cannabis demonstrators to immediately block this Medicaid plan was denied, but hearings are scheduled for 4/20
https://www.marijuanamoment.net/judge-rejects-anti-marijuana-groups-motion-to-block-cbd-and-thc-medicare-coverage-plan-setting-hearing-for-4-20/
In Colorado, healthcare facilities can now let terminally ill patients use medical cannabis, though the governor criticized the bill for allowing organizations to opt out
https://www.marijuanamoment.net/colorado-governor-signs-bill-to-allow-medical-marijuana-use-in-hospitals-but-criticizes-amendment-letting-facilities-opt-out/
A profile of Mark Pedersen, a man who was persecuted for treating chronically sick children with medical cannabis
https://www.esquire.com/news-politics/a70626609/mark-pedersen-jack-splitt-death-trial-cannabis-herculaneum-missouri/
🌐 International Updates 🌐
In Costa Rica, the first transfer of pharmaceutical-grade cannabis to the EU
https://cannabislaw.report/costa-rica-grower-ships-1st-export-of-gacp-certified-medical-cannabis-to-the-eu/
⚖️ Business, Laws & Education ⚖️
In the Zürich adult-use cannabis sales trial, variations in sales conditions had only a small impact on purchase behavior
Variations in Regulated Cannabis Sales Conditions and Their Effect on Purchase Behaviour: Findings from an Observational Study
https://karger.com/ear/article-pdf/doi/10.1159/000551031/4523383/000551031.pdf
For youth exposed to cannabis advertising, on the features most associated with fun, health or danger
How Do Cannabis Ads Influence Youth Perceptions of Cannabis?
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2645776
🚓 The War on Drugs 🚓
For designating drug cartels as terrorist organizations, a review of the military implications
Military Implications of Designating Drug Cartels as Foreign Terrorist Organizations and Specially Designated Global Terrorists: A Systematic Literature Review
https://www.researchgate.net/publication/403021200_Military_Implications_of_Designating_Drug_Cartels_as_Foreign_Terrorist_Organizations_and_Specially_Designated_Global_Terrorists_A_Systematic_Literature_Review
In Bolivia, on the innovative policies for the defense of the coca leaf & the rights of cocoa growers
Social Control of Coca Production: Lessons from the Tropic of Cochabamba, Bolivia
https://jied.lse.ac.uk/articles/10.31389/jied.292
And for Peru’s largest coca eradication campaign, it reduced schooling among children by ~1.5 years
Coca is gone: Evaluating the unintended consequences of crop eradication on educational outcomes in a former cocaine enclave in the Upper Peruvian Amazon
https://www.sciencedirect.com/science/article/pii/S0955395926001052
In the Mexican War on Drugs, a thesis project focusing on the mothers of the disappeared trying to reclaim the bodies of their children
Entanglements Of Sovereignties: Searching Mothers, Criminal Organizations And The State Apparatus Amid The Mexican War On Drugs
https://utoronto.scholaris.ca/server/api/core/bitstreams/bc72cbce-3589-4404-8ecc-21ab47d6ea9e/content
In the trials of drug couriers, how gendered narratives shape the outcomes
FROM VICTIM TO VILLAIN: HOW GENDERED NARRATIVES SHAPE DRUG COURIER TRIALS
https://digitalcommons.tourolaw.edu/cgi/viewcontent.cgi
“This is not just a movie plot, although it is exactly what happens in Maria Full of Grace, the 2004 film that brought global attention to the role of female drug mules. It is also real life for countless women across Latin America and beyond. Women who are in vulnerable situations: poor, young, isolated, are often targeted by traffickers who know how to exploit desperation. … But once these women are caught, their stories often vanish. In the courtroom, they are no longer seen as desperate or coerced. Instead, they are framed as either careless or cunning, naïve victims who should’ve known better or cold operators who knew exactly what they were doing.”
On the creative smuggling tactics to get drugs across the US border
https://san.com/cc/hidden-in-toys-food-and-freight-cartels-adapt-to-get-drugs-across-the-us-border/
In Uzbekistan, potatoes used to smuggle 72 kg of hashish
https://cannabislaw.report/mash-it-up-uzbekistan-foils-hashish-smuggling-hidden-in-potato-truck/
In Kenya, a poetic court case where a man defending his cannabis cultivation said that he did it because they are beautiful
https://cannabislaw.report/kenyan-court-cannabis-vs-roses/
“When asked by the Magistrate, why he didn’t grow roses instead, Kiprotich replied: ‘I stay away from roses because they attract women. I am not ready for the drama and complications that come with women right now. I prefer solace and the scent of my cannabis. They don’t ask me for anything, they just give me peace of mind’.”
For drug use & its criminalization, a perspective based on Kant
Kantian Perspectives on Drug Use and Drug Criminalization
https://www.tandfonline.com/doi/pdf/10.1080/0731129X.2026.2644079
🚗 Driving 🚗
For driving under the influence of cannabis, police data from Pennsylvania found legalization in a neighboring state increased a county’s rate of crashes involving a cannabis-positive driver
The effects of recreational marijuana legalization on driving under the influence of marijuana in a neighboring state: A cross-border quasi-experiment
https://www.sciencedirect.com/science/article/pii/S0022437526000472
🛡️ Harm Reduction News 🛡️
For the involuntary treatment of substance use disorders, the Canadian Society of Addiction Medicine made a statement against it, though they do say “there is a lack of high-quality evidence to either support or refute this approach to care”
Canadian Society of Addiction Medicine Position Statement on Involuntary Treatment
https://journals.lww.com/cja/fulltext/2026/03000/canadian_society_of_addiction_medicine_position.3.aspx
In Missouri, on the dangers of prisons for people with substance use disorders because of receiving punishment instead of treatment
https://www.themarshallproject.org/2026/03/05/st-louis-missouri-prison-opioid-addiction-lawsuit
Harm Reduction Research
For the parental use of psychoactives, a special issue on a harm reduction approach
Reimagining Support for Parenting in the Context of Parent Psychoactive Substance Use: A Harm Reduction Approach
https://www.tandfonline.com/doi/pdf/10.1080/15295192.2025.2605463
On a mobile Welsh harm reduction known as Spike on a Bike
Spike on a bike: mobile harm reduction in action
https://link.springer.com/article/10.1186/s12954-025-01394-7
For veterans, on the efficacy of harm reduction supply vending machines
Meeting Veterans Where They Are: Harm Reduction Supply Distribution via Vending Machines
https://journals.sagepub.com/doi/abs/10.1177/29767342261426185
For the drug decriminalization in British Columbia, interviews & data found limited help for unhoused or structurally vulnerable individuals
Public drug use, policing, and the limits of decriminalization in British Columbia: A mixed methods study
https://www.sciencedirect.com/science/article/pii/S0955395926001027
And that the barriers to health & harm reduction services persisted
Access to health and harm reduction services during drug decriminalization in British Columbia, Canada: a mixed-method study
https://link.springer.com/article/10.1186/s12889-026-26978-1
And an AI analysis found widespread public confusion
Detecting Misconception Surges in Opioid Policy: A Zero-Shot LLM Analysis of British Columbia’s Decriminalization Pilot
https://assets-eu.researchsquare.com/files/rs-8897658/v1_covered_1137d5a4-47be-4ada-bbf7-0e21a0952b2b.pdf
For sexual minority people attempting to access addiction treatment services, a review of 62 studies on their barriers
Barriers and facilitators to accessing addiction treatment services for sexual minority(LGBQ+) people: systematic review
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/AF67B6EFE324EE587A8830F87B90355E/S0007125026105893a.pdf/barriers-and-facilitators-to-accessing-addiction-treatment-services-for-sexual-minority-lgbq-people-systematic-review.pdf
🍄 Psychoactives, Psychedelics & Plant Medicines 🍄
An experiment of scientists using LSD to solve their most difficult problems, with a focus on Merlin Sheldrake of ‘Entangled Life’ fame
A personal story of using ibogaine to treat trauma at the Ambio clinic in Mexico
https://www.nytimes.com/2026/03/01/magazine/ibogaine-psychedelic-treatment-trauma-mental-health.html
For finding new drug names, on the use of a language model combing the Internet
What’s new on the market? Combining internet traces and pretrained language models to recognize emerging drug names
https://www.sciencedirect.com/science/article/pii/S0379073826001453
Psychedelics & MDMA
In people with depression, intranasal 5-MeO-DMT caused rapid & sustained reductions
Intranasal 5-MeO-DMT Concomitant with SSRI for Treatment-Resistant Depression: A Proof-of-Concept Trial
https://link.springer.com/article/10.1007/s40263-025-01250-z
For people on Reddit using psychedelics for mental health, a survey of their themes
“I can objectively view my trauma without feeling like I’m there”: Reddit discussions on self-reported use of psychedelics to address co-occurring substance use and mental health needs
https://akjournals.com/view/journals/2054/aop/article-10.1556-2054.2026.00487/article-10.1556-2054.2026.00487.xml
“Thematic analysis revealed positive experiences with psychedelics, including symptom relief for anxiety, depression, and PTSD, along with enhanced mood, inner peace, emotional healing, and shifts in perspective. These experiences were linked to reprocessing trauma and disrupting negative thought cycles. Users highlighted the potential for psychedelics to support long-term recovery from opioid use by fostering emotional resilience and clarity.”
For psilocybin, a case report of someone with cardiac arrest after eating a psilocybin-chocolate bar
26-CCC-15854-ACC TALK ABOUT A BAD TRIP!: PSILOCYBIN USE WITH PRE-EXISTING CARDIOVASCULAR DISEASE, A CASE REPORT
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3249
For an IV of DMT, on the pharmacokinetics
Dose-dependent pharmacokinetics and acute effects of intravenous bolus N,Ndimethyltryptamine: double-blind, randomized versus open-label dose-escalation administration study in healthy participants
https://www.nature.com/articles/s41398-026-03987-7_reference.pdf
For mescaline & psychiatric disorders, a review of 10 studies found help for “depression scales, well-being, nicotine dependence, alcohol use, and obsessions”
The Ethnopharmacological Use of Mescaline for Psychiatric Disorders: A Systematic Review
https://www.mdpi.com/1422-0067/27/7/3081
In people with depression, a review of 13 trials found mystical-type experiences linked to improvements in anxiety and/or depression outcomes
A scoping review of mystical-type experiences and mood symptom outcomes in psychedelic therapy clinical trials: comparing life-threatening disease and depressive populations
https://journals.sagepub.com/doi/pdf/10.1177/20451253261433836
For cancer pain, a review of using psychedelics
Psychedelics; an untapped therapeutic niche: a narrative review in the future of cancer pain management
https://www.sciencedirect.com/science/article/pii/S2590098626000102
For co-occurring PTSD & a substance use disorder, a review on the potential of MDMA-assisted therapy
MDMA-assisted therapy for PTSD and Substance Use Disorders: A Scoping Review of Feasibility and Future Directions
https://www.sciencedirect.com/science/article/pii/S295048482600007X
For adolescents with treatment-resistant mental health diseases, a commentary on the potential of psychedelic medicine
Classic psychedelic medicines for adolescent refractory mental health disease
https://akjournals.com/view/journals/2054/aop/article-10.1556-2054.2026.00452/article-10.1556-2054.2026.00452.xml
For derivatives of LSD, computer modeling of their potential toxicity
The toxicity of psychedelic LSD derivatives: 1-acetyl-LSD (ALD-52), 1-propionyl-LSD (1P-LSD), 1-butyryl-LSD (1B-LSD), 1-valeryl-LSD (1V-LSD) and 1-cyclopropylmethanoyl-LSD (1cP-LSD)—prediction of toxicological parameters relevant to clinical and forensic toxicology using multi-in silico approach
https://link.springer.com/article/10.1007/s00204-025-04255-1
Ketamine
For the self-described therapeutic use of ketamine, an analysis of Reddit posts
Ketamine Use in Self-Described Therapeutic Contexts: A Thematic Analysis of Reddit Posts
https://www.mdpi.com/2076-328X/16/4/480
For people with opioid use disorder, a combination of ketamine & Mindfulness-Oriented Recovery Enhancement (MORE) lowered cravings & opioid use
Ketamine-assisted Mindfulness-Oriented Recovery Enhancement for opioid use disorder: a randomized controlled trial
https://www.nature.com/articles/s44220-026-00625-5
For pain, on combining yoga & ketamine
Integrating Yoga Therapy and Ketamine Therapy for Chronic Pain Management
https://www.jpain.org/article/S1526-5900(25)01111-3/abstract
Kratom
For kratom, public health data on the increases in reports to the US National Poison Data System over the last 10 years
Increases in Kratom-Related Reports to Poison Centers — National Poison Data System, United States, 2015–2025
https://www.cdc.gov/mmwr/volumes/75/wr/mm7511a1.htm
A case report of kratom-induced liver injury
Kratom Consumption Associated With HerbInduced Liver Injury and a Pharmacokinetic Interaction: A Case Report
https://assets.cureus.com/uploads/case_report/pdf/478215/20260328-330966-25ul23.pdf
A case report as kratom as a trigger for arrhythmia problems
26-CCC-10170-ACC KRATOM AS A POTENTIAL TRIGGER FOR BRUGADA TYPE 1 ECG PATTERN AND ARRHYTHMIC SYNCOPE
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3178
And another
26-CCC-8308-ACC KRATOM: A DEADLY OUTCOME
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3158
And a case of heart failure
26-CCC-15323-ACC KRATOM-INDUCED CARDIOMYOPATHY: A RARE CAUSE OF REVERSIBLE HEART FAILURE
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3755
In withdrawal from kratom, a case report of cardiovascular toxicity
26-CCC-15620-ACC BEYOND NATURAL: TAKOTSUBO CARDIOMYOPATHY FROM KRATOM WITHDRAWAL
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3763
Cathinones
In France, cathinone use on the rise among people attending harm reduction facilities
The rising wave of cathinone use in people attending harm reduction facilities: a French repeated cross-sectional study (2019–2023)
https://link.springer.com/article/10.1186/s13722-026-00655-5
🍃 The Plant & its Products 🍃
🌱 Growing 🌱
On the effects of different light spectra on cannabis yield, mineral content & pigment levels
Effects of Green Light Deprivation and Red-to-Blue Ratio on Growth, Mineral Content, and Pigments in Salvia officinalis L. and Cannabis sativa L.
https://www.mdpi.com/2223-7747/15/7/1004
In different hemp germplasms, on evaluating their resistance to downy mildew (caused by Pseudoperonospora cannabina)
Evaluation of downy mildew resistance in the USDA Hemp Germplasm Repository using high-throughput and traditional phenotyping methods
https://apsjournals.apsnet.org/doi/abs/10.1094/PDIS-09-25-1916-RE
For cannabis flower development, an analysis of the transcribed genes
Transcriptomic insights into unisexual flower development in Cannabis sativa: conserved MADS-box networks and divergent developmental programs
https://link.springer.com/article/10.1186/s12870-026-08639-y
For the terpene synthesis enzymes of cannabis, a genetic & functional analysis
Expansion and functional diversification of terpene synthases shape volatile terpenoid landscape in Cannabis sativa
https://www.sciencedirect.com/science/article/pii/S2211383526001942
⚙️ Extracting, Analyzing & Formulating ⚙️
For the thermal breakdown of CBD & THC, computer modeling of their breakdown products with a focus on risk
Computational Modeling of Cannabidiol and Δ⁹-Tetrahydrocannabinol Derivatives from the Thermal Degradation of Cannabis sativa
https://www.acapublishing.com/dosyalar/baski/BEN_2025_1062.pdf
For CBD isolate formulated as an encapsulated powder emulsion, it caused significantly increased bioavailability compared to the Epidyolex oil
Comparative Pharmacokinetics and Safety of Cannabidiol in a Powder Formulation, CBtru®, vs an Oil-Based Formulation, Epidyolex®, Under Fasted and Fed Conditions in Healthy Participants: A Randomized Open-Label Cross-Over Phase I Study
https://link.springer.com/article/10.1007/s40263-026-01280-1
Evaluation of polymeric micelles with full-spectrum hydrophobic cannabis compounds
Physicochemical characterization of Pluronic® polymeric micelles for the aqueous compatibilization of full-spectrum hydrophobic compounds from Cannabis sativa
https://www.sciencedirect.com/science/article/abs/pii/S0167732226002862
🍞 Food & Nutrition 🍞
On using hempseed protein as a meat substitute
Hemp seed protein: a promising meat protein substitute with high nutritional value, high safety, and high meat like aroma characteristics
https://www.sciencedirect.com/science/article/abs/pii/S0308814626011787
🏗️ Industrial Uses & Fiber 🏗️
On creating noise barriers from recycled plastic, rubber granules & hemp shive panels
Development of Noise Barrier Made from Recycled Plastic and Rubber Granule Hemp Shive Panels
https://www.mdpi.com/2075-5309/16/7/1294
For food packaging, on creating nanocomposites films with hemp nanocellulose & zinc oxide nanoparticles
Synergistic reinforcement of alginate films with hemp nanocellulose and ZnO nanoparticles for enhanced mechanical, barrier, and antimicrobial performance
https://www.sciencedirect.com/science/article/abs/pii/S0141813026016272
For food packaging, on creating films using hemp essential oils for antioxidant & antimicrobial effects
Hemp Essential Oils as Novel Antioxidant and Bacteriostatic Agents in PLA-Based Packaging
https://www.mdpi.com/2073-4360/18/7/824
On converting hemp pomace (a byproduct of hemp oil production) into high-value products such as protein-enriched feed & industrial relevant enzymes
Valorization of Hemp Oil Pomace by Thermomyces lanuginosus for the production of value-added products
https://www.croris.hr/crosbi/publikacija/prilog-skup/935920
Conversion of Hemp Seed Oil Pomace into Value-Added Products
https://www.croris.hr/crosbi/publikacija/prilog-skup/935933
On creating curved beams with hemp fiber-reinforced laminated composites
Free Vibration of Hemp Fiber‐Reinforced Laminated Composite Curved Beams Using Generalized Differential Quadrature Method
https://4spepublications.onlinelibrary.wiley.com/doi/pdf/10.1002/pc.71022
On creating fire-resistant panels with hemp insulation
eNUCPUIR: Establishing patterns in the formation of a fire-resistant sip panel with hemp insulation
https://repositsc.nuczu.edu.ua/handle/123456789/28040
On adding hemp to biodegradable plastic composites via micro injection moulding
Optimizing Synergistic Reinforcement in PLA Composites: An Analysis on Hybrid Hemp-Sisal Fiber Loading Using Micro Injection Moulding (MIM)
https://iopscience.iop.org/article/10.1088/2631-8695/ae5922/meta
In mortar, hemp shives raised porosity & lowered strength but improved insulation
Comparative assessment of hemp shiv and basalt fibre reinforcements in lime-based mortars for sustainable building and heritage-compatible applications
https://www.sciencedirect.com/science/article/pii/S0950061826010494
For hemp fiber, on the best solvents for good wet spinning
Preparation and structure–property regulation of seed-type hemp-based regenerated cellulose filaments in a LiCl/DMAc solvent system
https://www.sciencedirect.com/science/article/pii/S0926669026005480
🌿 THE CANNA-SCIENCE ARCHIVE 🌿
For undergraduate organic chemistry students, on a teaching lab experiment on converting CBD to CBN using a one-pot reaction
From CBD to CBN: A Small-Scale, Project-Like Undergraduate Organic Lab Experiment Integrating Chemical Synthesis, TLC Co-spotting, Dry Column Vacuum Chromatography, and Antibacterial Testing
https://pubs.acs.org/doi/abs/10.1021/acs.jchemed.5c01541
🏥 Public Health & Bioassays 🏥
In older adults using medical cannabis, in interviews they described frequent use, self-experimentation because of a lack of guidance, replacing other medications with it & few had any concerns about cannabis use disorder, although one-third screened positive for it
Behaviors Related to Medical Cannabis Use in Older Adults: A Qualitative Study
https://www.tandfonline.com/doi/pdf/10.1080/02791072.2026.2644852
For US people using cannabis, a survey found one-third used medically, one-third recreationally & one-third for recreational & medical reasons
Reasons for Using Cannabis Among Adults in the United States: Associations with Demographics, Health Behaviors, Chronic Conditions, and Legal Status
https://www.mdpi.com/1660-4601/23/4/421
For people who used cannabis from adolescence through adulthood, on the related factors
An Ecological View of Adolescent Factors That Influence Cannabis Use from Adolescence to Midlife
https://www.tandfonline.com/doi/pdf/10.1080/29973368.2026.2644241
For the pediatric prescribing of CBD in the United States, a health record analysis
Prevalence of pediatric cannabidiol prescribing in the United States
https://link.springer.com/article/10.1007/s12519-026-01028-3
In older people with a disability, public health data found higher odds of nicotine-cannabis co-use
Poly-Substance Use of Nicotine, Alcohol, and Cannabis Among Adults Aged 50 and Older with Disability: Analysis of 2020–2022 Behavioral Risk Factor Surveillance System Data Across 33 U.S. States
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2647128
In Ugandan medical students, cannabis use was common
Cannabis Use Among Ugandan Medical Students: Prevalence, Predictors, and Coping Strategies in a Cross‐Sectional Study
https://onlinelibrary.wiley.com/doi/pdf/10.1002/brb3.71325
In monkeys, on the pharmacokinetics of oral THC
Pharmacokinetics of oral Δ9-tetrahydrocannabinol (THC) administration in vervet monkeys
https://link.springer.com/article/10.1186/s42238-026-00422-y
For screening saliva for THC, on a smartphone-based detection system
An immobilization-free aptamer-based liquid sensing display for the label-free detection of illicit Δ9-tetrahydrocannabinol
https://www.sciencedirect.com/science/article/abs/pii/S0039914026003966
In blood & dried blood spots, a comparative stability analysis of synthetic cannabinoids
Comparative Stability Assessment of Synthetic Cannabinoids in Dry Blood Spots and Blood using UHPLC-MS/MS: Implications for Forensic Applications
https://www.tandfonline.com/doi/abs/10.1080/15376516.2026.2652433
🧒 Adolescents & Young Adults 🧒
For US adolescents who used cannabis, those who reported it being recommended by a healthcare professional had more frequent use & were more likely to meet the criteria for cannabis use disorder
Medically Recommended Cannabis Use for US Adolescents
https://www.sciencedirect.com/science/article/abs/pii/S074937972600098X
For adolescents, medical & adult-use legalization was associated with positive cannabis attitudes
Cannabis legalization and early adolescent expectancies: Findings from the adolescent brain cognitive development study
https://www.sciencedirect.com/science/article/pii/S0376871626001195
In young adults from Washington State, they tended to use cannabis & alcohol heavily on the same days, but heavy use of cannabis (daily or near daily) was associated with less drinking
Nonmonotonic associations between cannabis use frequency and alcohol use in a statewide sample of young adults from Washington State
https://www.sciencedirect.com/science/article/abs/pii/S0749379726000966
🧠 The Brain & Neurological Disorders 🧠
For cannabinoid extraction & neurodegenerative protein spectroscopy, on a new unified laboratory system
An Integrated Multi-Variable Analytical Framework for Coupled Cannabinoid Extraction and Neurodegenerative Protein Spectroscopy in a Unified Laboratory System
https://www.researchgate.net/profile/Joshua-Animasaun-2/publication/403245893_An_Integrated_Multi-Variable_Analytical_Framework_for_Coupled_Cannabinoid_Extraction_and_Neurodegenerative_Protein_Spectroscopy_in_a_Unified_Laboratory_System/links/69c81e3e3c6189430670cce7/An-Integrated-Multi-Variable-Analytical-Framework-for-Coupled-Cannabinoid-Extraction-and-Neurodegenerative-Protein-Spectroscopy-in-a-Unified-Laboratory-System.pdf
💭 Mental Health, Addiction & Cannabis Use Disorder 💭
In adults using medical cannabis, the factors associated with possible cannabis use disorder were younger age, prolonged daily use, a preference for inhalation methods & recreational motives for cannabis use
Factors Associated with Possible Cannabis Use Disorder among Adults Using Medical Cannabis in Florida: A Cross-sectional Study
https://karger.com/mca/article-pdf/doi/10.1159/000550537/4522900/000550537.pdf
In Australian adults admitted to an acute psychiatric unit, the main reason for a medical cannabis prescription was anxiety, though the majority were admitted for psychosis
Medicinal Cannabis Prescription Before an Inpatient Psychiatric Admission: A Retrospective Observational Audit
https://journals.lww.com/practicalpsychiatry/abstract/2026/03000/medicinal_cannabis_prescription_before_an.2.aspx
In a mouse model of opioid use disorder, those without a CB1 receptor had an enhanced rewarding effect from morphine but no stress-induced reinstatement
Involvement of the cannabinoid system in stress-induced reinstatement to opioid use: a study in CB1 knockout mice of both sexes
https://www.sciencedirect.com/science/article/abs/pii/S0014299926002839
🧬 Reproduction & Hormones 🧬
In a mouse model of embryonic aluminum exposure impairing male offspring development & fertility, one of the pathways triggered is overactivation of the CB1 receptor
A novel adverse outcome pathway in aluminum-induced male infertility: Oxidative stress-mediated endoplasmic reticulum stress and endocannabinoid system activation delineated by network toxicology and metabolomics
https://www.sciencedirect.com/science/article/pii/S0147651326003891
🦠 The Immune System & Microbial 🦠
In people with HIV, cannabis users had lower levels of the inflammatory C-reactive protein
Associations Between Cannabis Use and Inflammatory Biomarkers Among People with HIV
https://journals.sagepub.com/doi/abs/10.1177/25785125261437619
🦴 Pain, Musculoskeletal, Inflammation & Surgeries 🦴
In older adults with chronic pain, those who intended to start using medical cannabis reported higher pain severity, pain interference & lower sleep quality
Factors Associated with Intention to Initiate Medical Cannabis Among Older Adults with Chronic Pain in a Prospective Cohort
https://www.jpain.org/article/S1526-5900(25)01196-4/abstract
In people with sickle-cell disease, cannabis users had higher odds of experiencing moderate to severe pain
Associations Between History of Cannabis Use, Pain, and Acute Care Outcomes
https://www.jpain.org/article/S1526-5900(25)01356-2/abstract
In people with a chronic post-surgical pain (which affects 20 to 40% of surgical patients), those who were using cannabis scored higher for perceived distress, but no other differences in psychological measures
Exploring the Influence of Cannabis Use in Patients with Chronic Post-Surgical Pain
https://www.jpain.org/article/S1526-5900(25)01394-X/abstract
In people with chronic pain, their insomnia status was not associated with their cannabis use or cannabis use disorder risk
Insomnia in Chronic Pain and Its Relation to Cannabis Use Patterns and Cannabis Use Disorder Risk
https://www.jpain.org/article/S1526-5900(25)01373-2/abstract
In a mouse model of skeletal muscle regeneration, a lack of CB2 receptors caused more inflammation & impaired muscle repair
Cannabinoid type 2 receptor regulates skeletal muscle regeneration by NLRP3-GSDMD mediated macrophage pyroptosis after injury
https://www.nature.com/articles/s41420-026-03077-z_reference.pdf
In a mouse model of opioids causing a hypersensitivity to pain, a drug that acted as a positive allosteric modulator of the CB1 receptor (making other drugs bind their more strongly) lowered their hypersensitivity, while chronic blocking of the MAGL enzyme (which breaks down 2-AG) did the same via the CB2 receptor
Endocannabinoid Approaches to Reducing Opioid-Induced Allodynia
https://www.jpain.org/article/S1526-5900(25)00969-1/abstract
In a female rat model of medication overuse headache, inhibition of ABHD6 (an endocannabinoid transporter) lessened pain, probably not via the CB1 receptor
Endocannabinoid Signaling in Medication Overuse Headache
https://www.jpain.org/article/S1526-5900(25)01343-4/abstract
❤️ The Heart & Blood ❤️
All the data from the site “jacc.org” is from this year’s American College of Cardiology conference (there’s more in the kratom & psychedelic sections above). I certainly do not mind their focus on the negative heart effects of cannabis, but I do resent their poster titles with lousy stoner puns.
For people who had heart attacks, public health data showed that the ones with THC in their system were younger & had lower in-hospital mortality, shorter hospital stays & less need for advanced support
26-CVT-15549-ACC TETRAHYDROCANNABINOL EXPOSURE AND IN-HOSPITAL OUTCOMES IN ACUTE MYOCARDIAL INFARCTION: A NATIONAL INPATIENT SAMPLE ANALYSIS
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3127
In 3 young chronic cannabis using males with no other cardiovascular risk factors, case reports on their acute coronary syndromes
26-CCC-8309-ACC BETWEEN JOINTS AND HEARTBREAKS: FROM PUFF TO PAIN, EXPLORING MARIJUANA’S IMPACT IN ACUTE CORONARY EVENTS
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3336
For a blocked heart, a case report of someone with a significant cannabis history
Suspected Cannabis-Induced Acute Coronary Syndrome and Advanced Heart block
https://journals.sagepub.com/doi/pdf/10.1177/23247096261435473
A case report of a chronic cannabis user with prolonged sinus arrest (failure of a heart beat signal)
26-CCC-16622-ACC THE JOINT THAT STOPPED THE BEAT: SINUS ARREST IN A PATIENT WITH CHRONIC MARIJUANA USE
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3266
For vaping cannabinoids, a case report of a rare heart inflammation
26-CCC-11946-ACC FULMINANT EOSINOPHILIC PERIMYOCARDITIS PRESENTING WITH SEVERE, NON-OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY AND CONCOMITANT CARDIAC TAMPONADE LEADING TO MIXED SHOCK AFTER VAPING CANNABINOIDS
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3621
For a young female, a case report of synthetic cannabinoids & a cardiac arrest
26-CCC-18139-ACC ARRHYTHMOGENIC POTENTIAL OF SYNTHETIC CANNABIS: EVIDENCE OF QTC PROLONGATION
https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.02.3280
In a mouse model of sickle-cell disease, inhibition of the MAGL enzyme (which breaks down 2-AG) reduced mechanical pain sensitivity & restored motor function
Evaluation of Monoacylglycerol Lipase Inhibition as a Novel Analgesic Strategy in a Humanized Mouse Model of Sickle Cell Disease
https://www.jpain.org/article/S1526-5900(25)01017-X/abstract
🍽️ The Guts, Nutrition & the Microbiome 🍽️
In a mouse model of ulcerative colitis, rectal administration of a combination of CBD & the fatty acid sodium propionate increased colon length, reduced disease scores, lowered body weight loss & lessened damage
A novel enema formulation containing cannabidiol and sodium propionate for ulcerative colitis: preclinical assessment in a murine model
https://link.springer.com/article/10.1186/s42238-026-00400-4
💨 The Lungs 💨
After legalization of cannabis in Massachusetts, there was an increase in young people with pneumomediastinum (air in the space between the lungs)
Trends in Pediatric Pneumomediastinum Following Cannabis Legalization in Massachusetts
https://www.sciencedirect.com/science/article/abs/pii/S0022480426001216
In older mice with lung scarring, activating their CB2 receptor did something behind a paywall…
Therapeutic Potential of CB2 Agonist Osteogenic Growth Peptide in Lung Fibrosis in Aged Mice
https://academic.oup.com/ajrcmb/advance-article-abstract/doi/10.1093/ajrcmb/aanag052/8541984
🎗️ Cancer & Chemotherapy 🎗️
In tumors of the central nervous system, CBD reduced cell viability & migration
Acute Anti-Proliferative and Anti-Migratory Effects of Cannabidiol on C6 Rat Glioma, SH-SY5Y Human Neuroblastoma, and HT22 Mouse Hippocampal Neuronal Cell Cultures
https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2026.1727831/abstract
For anticancer effects, on the creation of a CBD-loaded starch microsphere
Preparation, in vitro digestive release behavior, and anticancer activity of cannabidiol-loaded porous starch microspheres
https://www.sciencedirect.com/science/article/pii/S2772566926001138
For CBD conjugates as antitumor agents, on improving their solubility & antitumor activity
Solubility-Improved and Antitumor Activity of (-)-Cannabidiol Conjugates
https://assets-eu.researchsquare.com/files/rs-9148396/v1/3ee6052c-1a05-4f96-bff1-d145a17d1e5b.pdf
🔬 Biochemical Discoveries & Research Tools 🔬
For the effects of CBD on membranes, on a proposed phase field model
Cannabidiol (CBD) Induces Lipid Microdomain Disruption or Budding in Ternary Mixtures
https://pubs.acs.org/doi/full/10.1021/acs.jpcb.5c06965
For analyzing the CB1 receptor, on advances in chemical probes
Unlocking the Multifaceted Role of CB1R in the Endocannabinoid System with Labeled Chemical Probes
https://www.chimia.ch/chimia/article/view/2026_165
For the minor cannabinoid cannabidiphorol (CBDP) at the CB1 receptor, on how it causes negative allosteric modulations at 2 distinct sites
Cannabidiphorol (CBDP) acts as a negative allosteric modulator at two distinct sites of cannabinoid receptor 1
https://www.nature.com/articles/s42004-026-01990-z
Thanks.
- lex
PS: For this week’s Delta blues, ‘Parchman Farm’, a collection of recordings from the late ‘30s by Bukka White. Born in Mississippi in ~1906, Bukka learned fiddle tunes from his father but once he started playing the guitar, his grandmother didn’t like hearing “that Devil music” in the house (though the music must have been in the blood, because his cousin was BB King). In 1930, a talent scout for Victor recorded 14 of White’s songs but only released 4 of them. With the Great Depression setting in, he didn’t get another chance to record until Big Bill Broonzy invited him to come to Chicago & record for Lester Melrose. But White was in legal trouble for shooting someone in the thigh (he claimed it was self-defense after his friend was ambushed along the highway). He jumped bail & headed to Chicago where he managed to record 2 side before being caught & returned to Mississippi for a 3-year sentence at Parchman Farm.
While he was inside, his song ‘Shake ‘Em Down’ became a hit. Plus, he recorded two songs for the Lomaxes, the famed folklorists who were touring prisons & recording for the Library of Congress. When White got out, he recorded 12 songs for Melrose & these were considered the pinnacle of his recording career, many going on to become classics of the Delta blues. But then, with World War 2 beginning, he started working in a factory & disappeared from public view.
In 1962, when Bob Dylan covered ‘Fixin’ to Die Blues’ on his debut album, blues enthusiasts tracked Bukka White down & he quickly recorded 3 albums of material. Despite being an aging patriarch of the Delta blues, he was a stylish dresser in excellent health who well-enjoyed the folk festival & coffeehouse circuit of the 1960s, where he shared his stories as well as his songs. He stayed on the circuit until his death of cancer at the age of ~71.
This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.