C&P#103: CBD for exercise, psychosis & mosquito larvae + combo with THCV for weight loss
South Africa goes legal!
This week…
A CBD & THCV combo for reducing weight
Big review of CBD for exercise recovery
CBD for psychosis
On treatments for cannabis use disorder
Big week on harms to adolescents as well as from prenatal exposure
A review of drug-cannabinoid interactions for treating major diseases
Three on the terpene beta caryophyllene: pain, blood pressure, skin healing
Killing yellow fever carrying mosquito larvae with CBD
For night vision, rat retinas use CB1 receptors
DMT patches!
Hello everyone,
Welcome to the 103rd edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science + assorted canna-news & psychedelic updates. On the cannabinoids, ask me anything.
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The Canna-Science Writeup:
Analysis of the week's best papers, sponsored by CV Sciences
#Anxiety
In an Ayurvedic medicine study of anxiety, two months of a cannabis oil improved a number of domains
A pilot study to evaluate the safety and efficacy of ‘Canna Relief’ Stress Management Oil after oral consumption in patients with Stress and Mild to Moderate Anxiety Disorder
https://www.researchgate.net/publication/380768141_A_pilot_study_to_evaluate_the_safety_and_efficacy_of_'Canna_Relief'_Stress_Management_Oil_after_oral_consumption_in_patients_with_Stress_and_Mild_to_Moderate_Anxiety_Disorder
In this study out of India, the researchers selected 40 participants diagnosed with an anxiety disorder. According to the old Ayurvedic texts, anxiety can be considered a Prajnaparada, a crime against our own intellect. For treatment, after each evening meal for two months, the participants were given 4 drops of an extract containing a 1:2 ratio of CBD and the minor cannabinoids including CBG and CBN (this breaks down to ~4.5 mg CBD and ~1.5 mg of the other cannabinoids). The formulation also included a proprietary blend of valerian, spikenard, and nut grass.
Intriguingly, in the results, the participants are also broken down by their dosha, an Ayurvedic definition of someone’s constitution that often necessitates different treatment plans. For instance, the dosha Pitta-Kaphaja Prakriti is especially linked to the development of anxiety.
Over the course of the treatment, participants experienced…
Significant improvements on the Hamilton anxiety scale
Reductions on the Insomnia Severity Index and the Athens Insomnia Scale as well as improvements on the Pittsburgh Sleep Quality Index
Reduced levels of the stress hormone cortisol in the saliva as well as reduced salivary levels of amylase, an enzyme that breaks down sugar and that is linked to chronic stress
No changes to cholesterol levels, blood sugar levels, or liver function tests
This paper is freely available to download and has more on the Ayuruvedic side of things if that is of interest to you. For more research, see the Anxiety, Stress & Depression page of CVResearch.info.
#Exercise
For exercise recovery, a review of 70 studies found CBD to have many beneficial properties
Prospective Analysis of Cannabidiol's Effectiveness in Post-Exercise Recovery: An integrative Systematic Review and Research Agenda
https://www.researchgate.net/publication/380480178_Prospective_Analysis_of_Cannabidiol's_Effectiveness_in_Post-Exercise_Recovery_An_integrative_Systematic_Review_and_Research_Agenda
Finally, a strong and wide-ranging review about CBD’s potential for exercise recovery in athletes (analyzed by someone who just finished a 30-minute run and ~200 pushups by taking a PlusCBD Daily Balance 50mg softgel). While the authors rightly lament that more CBD research needs to be done directly in athletes, their review of 70 studies from the last ~35 years is roughly divided into thirds of preclinical trials, clinical trials, and meta-analyses. Their money quote is right in the abstract: “CBD demonstrated potentially beneficial properties for athlete recovery such as anti-inflammatory, neuroprotective, anxiolytic, and analgesic effects with doses ranging from 5-600mg.”
As the authors point out, while full-spectrum extracts are banned by most international sports leagues, the World Anti-Doping Agency does not include isolated CBD on their prohibited list.
The evidence assembled here suggests CBD’s benefits for…
A “positive effect on the treatment of chronic pain, spasticity, and sleep quality”
“A potential role in managing mood disorders”
“Multiple benefits at the immune level, including anti-inflammatory and immunosuppressive effects”
Neuroprotective effects
Sports performance, recovery, and the promotion of the healing of traumatic skeletal injuries
While it’s true that more CBD clinical studies here would be helpful, we already have a wealth of anecdotes from professional athletes on using cannabinoids for their pain and recovery from football, basketball (Magic Johnson?!), and soccer injuries (Megan Rapinoe?!), from regular people for helping you stick to an exercise regime (“the dose and run”) as well as evidence on the endocannabinoid system itself potentially underlying the runner’s high. See more exercise studies on the Musculoskeletal System & Exercise page of CVResearch.info.
#Psychosis
In people with psychosis or at ultra-high risk for psychosis, a review of 13 studies found CBD helped with positive & negative symptom improvement
Left hemisphere lateralization of the limbic system and frontoparietal network (FPN) correlates with positive and negative symptom improvement following cannabidiol (CBD) administration in psychosis and ultra-high risk (UHR) populations: A voxel-wise meta-analysis
https://pubmed.ncbi.nlm.nih.gov/38735261/
This meta-analysis of 13 studies is a bit complicated, but psychosis itself is certainly complicated. These researchers included ten studies of people with psychosis and three studies of people at ultra-high risk for psychosis treated with CBD. Combining the data, they found a “robust, convergent correlation” between giving someone CBD during different tasks (i.e. emotion recognition, verbal memory recall, inhibitory control) and calming the brain’s limbic (emotional) system or frontoparietal network (a control network of executive function and goal-oriented cognitively demanding tasks). They found that decreased activity of the limbic system was correlated with the improvement of positive symptoms (defined as the changes in thoughts or feeling that are added on to a person’s experience such as paranoia, hallucinations, hearing voices, delusions, abnormal motor behavior, and disorganized thinking). Decreased activity in the frontoparietal network was correlated to improvements in negative symptoms (defined as the absence or reduction of common behaviors such as apathy, asociality, lack of motivation, anhedonia (lack of pleasure from enjoyable activities), alogia (poverty of speech), and affective flattening (a reduced expression of emotions through facial expressions, vocal tone, and gestures)). While a large body of research exists on the use of CBD for psychosis, it's worth noting that the doses involved often amount to hundreds of milligrams per day. But for something as serious as psychosis, CBD should be considered by anyone struggling with it. Find more research around this topic on the Psychosis & Schizophrenia page of CVResearch.info.
Best Of Cannabinoid Science...
In ‘Odd Effects from the War on Drugs’ news, snakes that are hard to study because they tend to live around cartel-controlled cannabis & opium grows in Mexico
Fangs and foliage: Unearthing the haemotoxic secrets of cannabis-dwelling rattlesnakes
https://www.sciencedirect.com/science/article/pii/S0041010124003283
Clinical
In a study of metabolic syndrome, a CBD/THV strip caused weight loss & a decrease in abdominal girth, systolic blood pressure & cholesterol levels
Weight Loss and Therapeutic Metabolic Effects of Tetrahydrocannabivarin (THCV)-Infused Mucoadhesive Strips
https://publications.sciences.ucf.edu/cannabis/index.php/Cannabis/article/view/206
In people with multiple sclerosis, public health data from England shows an increasing trend for the number of prescriptions for Sativex (a 1:1 THC:CBD spray)
Trends in prescription and cost of Sativex, a cannabinoid-based medicine, in treating patients with multiple sclerosis in England
https://pubmed.ncbi.nlm.nih.gov/38726319/
Among Canadians with inflammatory bowel disease, a survey found an increase in their cannabis use but only half would discuss it with their physicians
Cannabis Use in Patients With Inflammatory Bowel Disease Following Legalization of Cannabis in Canada
https://pubmed.ncbi.nlm.nih.gov/38800569/
In people with chronic & neuropathic pain, a study of their cannabinoid levels from different types of ingestion methods & cannabinoid mixtures
Cannabinoid levels description in a cohort of patients with chronic and neuropathic pain treated with Cannabis decoction: A possible role of TDM
https://pubmed.ncbi.nlm.nih.gov/38713939/
In people having breast reduction surgery, THC use did not increase complications or the need for postoperative painkillers
Tetrahydrocannabinol Use Does Not Increase Postoperative Analgesia Needs Or Complications After Breast Reduction
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11089987/
On the brain changes from THC in chronic cannabis users
Intoxication due to Δ9-tetrahydrocannabinol is characterized by disrupted prefrontal cortex activity
https://pubmed.ncbi.nlm.nih.gov/38714786/
On creating a novel eye-tracking metric for identifying recent cannabis use
Effects of recent cannabis consumption on eye-tracking and pupillometry
https://pubmed.ncbi.nlm.nih.gov/38655106/
Harms
A review of cannabinoid drug interactions with therapeutics for major diseases
Drug-Cannabinoid Interactions in Selected Therapeutics for Symptoms Associated with Epilepsy, Autism Spectrum Disorder, Cancer, Multiple Sclerosis, and Pain
https://pubmed.ncbi.nlm.nih.gov/38794183/
“Pharmacokinetic interactions with anticonvulsant medications have also been reported, as have pharmacodynamic interactions between cannabinoids and medications with sympathomimetic effects (e.g., tachycardia, hypertension), central nervous system depressants (e.g., drowsiness, ataxia), and anticholinergics (e.g., tachycardia and somnolence).”
And a review of 54 papers on cannabis drug-drug interactions
Evaluation of potential drug-drug interactions with medical cannabis
https://pubmed.ncbi.nlm.nih.gov/38720531/
“The analysis revealed that antiepileptics had the most evidence of interaction with cannabis, followed by clobazam (CLB), warfarin, and tacrolimus.”
On the trajectory to cannabis use disorder by some giants in the field
The Developmental Trajectory to Cannabis Use Disorder
https://pubmed.ncbi.nlm.nih.gov/38706340/
In adolescents undergoing surgery, cannabis use disorder associated with postoperative complications
Trends in Adolescent Comorbid Cannabis Use Disorder and Postoperative Complications
https://pubmed.ncbi.nlm.nih.gov/38708543/
“The adjusted odds of respiratory complications, ICU admission, mechanical ventilation, and extended hospital stay were significantly higher in adolescents with CUD.. The propensity score-adjusted odds of postoperative mortality or stroke for adolescents with CUD were not significantly increased.”
A review found that adolescent cannabis users were 1.5x more likely to experience suicidal ideation
Suicide ideation and psychotropic recreational drug use by adolescents: a systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/38655989/
And a chart review that found cannabis vaping among adolescents to be associated with suicidal ideation & past 30 days suicide attempts
Cannabis Vaping Is Associated With Past 30-Day Suicide Attempts and Suicidal Ideation Among Adolescents in a Psychiatric Inpatient Setting
https://www.sciencedirect.com/science/article/pii/S294973292400036X
On mood disorders, a review of studies found “cannabis use may negatively influence the development, course, and prognosis of MDD [major depressive disorder] and BD [bipolar disorder]”
Cannabis use and mood disorders: a systematic review
https://pubmed.ncbi.nlm.nih.gov/38655516/
And a Swiss study that found increased cannabis use linked to more ADHD & depressive symptoms
Cannabis use and its association with psychopathological symptoms in a Swiss adult population: a cross-sectional analysis
https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1356988/full
A review of treatments for cannabis use disorder
Emerging pharmacotherapy for the treatment of cannabis use disorder
https://pubmed.ncbi.nlm.nih.gov/38717605/
“Superiority over control of cannabidiol, gabapentin, galantamine, nabilone plus zolpidem, nabiximols, naltrexone, PF-04457845, quetiapine, varenicline, and topiramate were observed through the cannabinoid, glutamatergic, γ-aminobutyric acidergic, serotonergic, noradrenergic, dopaminergic, opioidergic, and cholinergic systems.”
And a small review of the mechanisms of how these cannabis use disorder treatments might be working
Mechanisms of Behavior Change for Functional Improvements in Cannabis Use Disorder Treatments: Current Science and Future Outlook
https://link.springer.com/article/10.1007/s40429-024-00578-8
A case report of someone with fibromyalgia using cannabis to treat the pain but when they stopped using cannabis because they found other pain-controlling methods, it also reduced a number of their psychotic symptoms
A Cautious Reminder about the Potential Risk of Psychosis When Cannabis Is Used as a Treatment for Chronic Pain
https://www.sciencedirect.com/science/article/pii/S277302122400021X
A case report of a cannabis smoker with air in their chest cavity, potentially from cannabinoid hyperemesis syndrome
Spontaneous Pneumomediastinum as the Result of Marijuana Use
https://www.acpjournals.org/doi/full/10.7326/aimcc.2023.1275
A case report about a cannabis user with pericarditis (inflammation of the sac around the heart) & a review on the emerging link between cannabis use & heart problems
Marijuana Induced Pericarditis: An Emerging Crisis
https://scholarlycommons.gbmc.org/cgi/viewcontent.cgi?article=1351&context=jchimp
Reviews
For Alzheimer's disease, a review of CBD helping via the reduction of oxidative stress & neuroinflammation
Modulation of Oxidative Stress and Neuroinflammation by Cannabidiol (CBD): Promising Targets for the Treatment of Alzheimer's Disease
https://pubmed.ncbi.nlm.nih.gov/38785534/
For epilepsy, a meta-analysis of six studies on the use of CBD
The use of cannabidiol as a treatment for quantitative seizures reduction in pharmacoresistant epilepsy, a systematic review and meta-analysis
https://www.researchsquare.com/article/rs-4366244/v1
A review of arachidonic acid, the fatty acid used to create anandamide & one of the most ubiquitous polyunsaturated fatty acids in our systems
Arachidonic acid in aging: New roles for old players
https://pubmed.ncbi.nlm.nih.gov/38710468/
Preclinical
Against the larva of the mosquitoes who carries yellow fever, the larvicidal activity of cannabis leaf extracts & CBD
Larvicidal Activity of Hemp Extracts and Cannabidiol against the Yellow Fever Mosquito Aedes aegypti
https://www.researchgate.net/publication/380475222_Larvicidal_Activity_of_Hemp_Extracts_and_Cannabidiol_against_the_Yellow_Fever_Mosquito_Aedes_aegypti
In a mouse model of liver fibrosis, CBD improved liver function & reduced liver damage & scarring progression via the inhibition of inflammatory cytokines & the activation of PPAR-α receptors (which control genetic transcription)
Cannabidiol alleviates carbon tetrachloride-induced liver fibrosis in mice by regulating NF-κB and PPAR-α pathways
https://pubmed.ncbi.nlm.nih.gov/38711461/
In a rat model of methamphetamine use disorder, CBD helped with addictive behaviors via dopamine receptors in the hippocampus (memory center of the brain)
Hippocampal D1-like dopamine receptor as a novel target for the effect of cannabidiol on extinction and reinstatement of methamphetamine-induced CPP
https://pubmed.ncbi.nlm.nih.gov/38729234/
Of relevance to epilepsy, CBD directly inhibited the BK channel (voltage-gated potassium channels with large amounts of potassium known as ‘Big Potassium’ (Big K)))
Direct Inhibition of BK Channels by Cannabidiol, One of the Principal Therapeutic Cannabinoids Derived from Cannabis sativa
https://pubmed.ncbi.nlm.nih.gov/38708937/
For autism, a molecular docking study of how THC is beneficial for lowering inflammatory factors
Evaluation of Δ9 -tetrahydrocannabinol Effect on Autism Inflammatory Factors by Molecular Docking Study
https://sjmshm.srpub.org/article-3-189-fa.pdf
In a neuronal model of damage from overexcitation or oxidative stress, CBD caused protection from DNA fragmentation & for the membranes of the mitochondria (powerhouse of the cell) but enhanced toxic effects at high doses
Protective Effects of Cannabidiol (CBD) against Qxidative Stress, but Not Excitotoxic-Related Neuronal Cell Damage-An In Vitro Study
https://pubmed.ncbi.nlm.nih.gov/38785971/
In rat retinas, CB1 receptors helped to regulate their night visual processing via glutamate release
Non-canonical type 1 cannabinoid receptor signaling regulates night visual processing in the inner rat retina
https://pubmed.ncbi.nlm.nih.gov/38799553/
An evergreen note on reading restricted papers:
First stop for seeing if there’s a free version of a paper, use the Google Scholar Chrome extension (Mac version), Google Scholar itself or try ResearchGate.
Three other helpful browser extensions are: Unpaywall, Open Access Button & PaperPanda
For the infamous backdoor, use Sci-Hub – the pirated papers repository (Chrome extension here). This works better for older paper than the stuff that just came out.
Finally, email the author. They’re almost always happy to oblige because, thanks to the predatory academic publishing system, they don’t make a dollar off of their papers.
the Headlines & Fav Articles
In a new letter, a DEA chief says that the THC limit for hemp products includes THCA (which when heated, becomes THC)
https://www.marijuanamoment.net/dea-says-thca-does-not-meet-the-definition-of-legal-hemp-as-congress-weighs-cannabinoid-recriminalization-in-farm-bill
In Delaware, people over 65 now allowed to self-certify for medical cannabis prescriptions
https://www.marijuanamoment.net/delaware-governor-signs-bill-to-expand-medical-marijuana-access-by-letting-doctors-recommend-it-for-any-condition
#CannabisForTheElders!
This has been my platform since I first started getting into this plant. It’s a panacea for the whole host of conditions we describe as aging.
Alabama is putting pregnant people in jail for testing positive for cannabis or other psychoactives (in part of a much larger article about Alabama’s War on Women)
https://www.rollingstone.com/politics/politics-features/alabama-fetal-personhood-ivf-abortion-1235018366/
International
South Africa legalizes cannabis possession & cultivation
https://www.marijuanamoment.net/south-african-president-signs-marijuana-legalization-bill-into-law/
In Canada, an analysis found that adult use laws moderately increased initiation & use of cannabis among adolescents, young adults & adults
The Impact of Recreational Cannabis Markets on Cannabis Use Among Adolescents and Adults: A Synthetic Control Analysis
https://www.researchgate.net/publication/380417609_The_Impact_of_Recreational_Cannabis_Markets_on_Cannabis_Use_Among_Adolescents_and_Adults_A_Synthetic_Control_Analysis
While this analysis found an initial bump that later decreased
Impact of Legalization on Cannabis Use, Attitudes, and Purchasing Preferences: A Repeated Cross-Sectional Survey of Canadian Young Adults
https://publications.sciences.ucf.edu/cannabis/index.php/Cannabis/article/view/203
In Canada, on the debate on easing promotion & advertisements
Five Years After Cannabis Legalization, Is It Time to Ease Restrictions on Promotion?
https://pubmed.ncbi.nlm.nih.gov/38721730/
On why young women in Nigeria are using cannabis & the harm reduction methods they employ
The social-structural contexts of cannabis consumption and harm reduction among young Nigerian women
https://www.sciencedirect.com/science/article/abs/pii/S0955395924001361
On the history of cannabis representation in 19th century Australian periodicals
“Psychic Poisons” or Emerging Medicines: A Thematic Analysis of Cannabis Representations in Australian Nineteenth Century Periodicals
https://journals.sagepub.com/doi/pdf/10.1177/01968599241248611
The Laws, The War on Drugs & the End of Prohibition
Adult use cannabis laws found linked to an increase in intimate partner violence
High times and troubled relationships: Recreational marijuana laws and intimate partner violence
https://pubmed.ncbi.nlm.nih.gov/38733865/
“Utilizing a difference-in-difference methodology spanning 2006-2016 across 39 states, we find that RMLs [Recreational Marijuana Laws] produce a 20 percent increase in IPV incidents per 100,000 individuals, which appears to be mediated through mental health issues and binge drinking.”
On regulatory challenges in the cannabis industry
Regulatory Challenges and Opportunities in the Cannabis Industry
https://journalisslp.com/index.php/isslp/article/view/52
On using lessons from alcohol research on the legalization of adult use cannabis
Considerations for Research in States with Recent or Pending Legalization of Non-Medical Cannabis: Lessons Learned from Alcohol and Opportunities for Research
https://link.springer.com/article/10.1007/s40429-024-00579-7
Psychedelics, Plant Medicines & Other Psychoactives
The Psychoactive Research
In a study of an ayahuasca church, taking the sacrament was associated with improved cognitive function & memory
Long-term ayahuasca use is associated with preserved global cognitive function and improved memory: a cross-sectional study with ritual users
https://pubmed.ncbi.nlm.nih.gov/38780800/
Guidelines for using touch during group psilocybin therapy
Evolving Guidelines for the Use of Touch During a Clinical Trial of Group Psilocybin-Assisted Therapy
https://www.liebertpub.com/doi/10.1089/psymed.2023.0069
DMT patches!
Novel extended-release transdermal formulations of the psychedelic N,N-dimethyltryptamine (DMT)
https://www.sciencedirect.com/science/article/pii/S0928098724001155?via%3Dihub
A new framework for understanding the space-time hierarchy of DMT
Harmonic decomposition of spacetime (HADES) framework characterises the spacetime hierarchy of the DMT brain state
https://www.biorxiv.org/content/10.1101/2023.08.20.554019v1
The Plant & the History
Growing, Farming & Processing
On the benefits of the plant growth regulators chlormequat chloride (CCC) & paclobutrazol
Fertiliser supplementation with a PGR complex of chlormequat chloride (CCC) and paclobutrazol (PBZ) alters Cannabis sativa growth
https://www.tandfonline.com/doi/full/10.1080/01140671.2024.2346580
A thesis project on how temperature & genetics regulated the accumulation of anthocyanins (a type of flavonoid that gives the purple color)
GENETICS AND ENVIRONMENTAL FACTORS SHAPING CANNABIS PHENOTYPES: A STUDY ON TEMPERATURE EFFECTS AND GENETIC REGULATION OF ANTHOCYANIN ACCUMULATION IN CANNABIS SATIVA
https://minds.wisconsin.edu/bitstream/handle/1793/85243/Sean%20Kim%20Master%20Thesis%20II.pdf?sequence=1
A thesis project on the microbial ecology of indoor grows
Microbial Ecology of Controlled Environment Cannabis Cultivation Facilities
https://atrium.lib.uoguelph.ca/server/api/core/bitstreams/315948f5-f17f-4c76-9f5f-f8efe264d24b/content
A quality control regimen from Italy
OILVEQ: an Italian external quality control scheme for cannabinoids analysis in galenic preparations of cannabis oil
https://pubmed.ncbi.nlm.nih.gov/38727000/
On the best parameters for cannabis leaf extraction
Bioactive Compound Extraction of Hemp (Cannabis sativa L.) Leaves through Response Surface Methodology Optimization
https://www.mdpi.com/2624-7402/6/2/75
18 genetic markers associated with traits of cannabis found in a genome-wide association study
Genetic insights into agronomic and morphological traits of drug-type cannabis revealed by genome-wide association studies
https://pubmed.ncbi.nlm.nih.gov/38644388/
A thesis project on the molecular regulation of the trichomes
Molecular Regulation of Glandular Trichome Initiation and Morphogenesis in Cannabis sativa L.
https://opal.latrobe.edu.au/articles/thesis/Molecular_Regulation_of_Glandular_Trichome_Initiation_and_Morphogenesis_in_Cannabis_sativa_L_/25744944
Food & Nutrition
In hemp seeds, the effects of boiling & germination on their profile of bioactives
The role of germination and boiling processes on bioactive properties, fatty acids, phenolic profile and element contents of hemp seeds and oils
https://www.sciencedirect.com/science/article/pii/S2772753X24001151
Industrial Use
On building hemp boats in New Zealand
From Seed to Sail: The Sustainable and Commercial Viability of Boat Building with Hemp Bio Composites in New Zealand
https://openrepository.aut.ac.nz/items/4a9bb193-0e2b-43f2-a84c-7d54a0ab6406
On using hemp-based carbon to absorb toxic dyes
Sustainable approach to dye adsorption: hemp-based activated carbon as an effective adsorbent
https://www.tandfonline.com/doi/abs/10.1080/03067319.2024.2346192
On using hemp stems & roots with activated carbon to remove chromium & paracetamol
Sequestration of hexavalent chromium and paracetamol from water using deoiled hemp stem-twigs and roots and activated carbon
https://www.sciencedirect.com/science/article/pii/S2667010024000970
A hemp-based aerogel with high fire resistance
A waste hemp-based biomass carbon aerogel with high fire-resistance
https://onlinelibrary.wiley.com/doi/abs/10.1002/app.55616
CANNABINOID SCIENCE
Public Health
A survey of educators found interest in teaching cannabis harm reduction but many felt unprepared to address the topic
A survey of educator perspectives toward teaching harm reduction cannabis education
https://pubmed.ncbi.nlm.nih.gov/38718060/
On the simultaneous use of cannabis & alcohol broken down by sexual identity
Trends in simultaneous alcohol and marijuana use among US adult recent drinkers: Differences by sexual identity, 2015–2020
https://www.sciencedirect.com/science/article/pii/S2949916X24000653
Racial disparities in cannabis use among adults living with children
Racial Disparities in Patterns and Modes of Current and Daily Marijuana Use among Adults Living with Children
https://pubmed.ncbi.nlm.nih.gov/38656451/
Adolescents & Young Adults
In Canadian adolescents, the dual use of cannabis & alcohol had an elevated risk of impaired driving
The association between single and dual use of cannabis and alcohol and driving under the influence and riding with an impaired driver in a large sample of Canadian adolescents
https://pubmed.ncbi.nlm.nih.gov/38656911/
A book chapter on parenting young people who use cannabis
Parenting and Providing Care to Adolescents and Young Adults Who Use Cannabis
https://www.igi-global.com/chapter/parenting-and-providing-care-to-adolescents-and-young-adults-who-use-cannabis/346491
The Brain
In a survey of people with Parkinson's disease, only a third of them said they felt supported by their doctor about using cannabis
Don’t Ask, Don’t Tell: Cannabis Use in Patients Diagnosed With Parkinson Disease
https://www.naturalmedicinejournal.com/journal/don-t-ask-don-t-tell-cannabis-use-in-patients-diagnosed-with-parkinson-disease
In a mouse model of sepsis, a drug that activates the CB1 receptor inhibited their inflammatory factors & Improved cognitive function
Cannabinoid receptor 1 agonist arachidonyl-2'-chloroethylamide (ACEA) improves sepsis-associated encephalopathy by inhibiting inflammatory factors]
https://pubmed.ncbi.nlm.nih.gov/38710516/
In a mouse study of dopamine, while cannabinoids did not show abuse liability they did mediate dopamine functioning
Indirect and direct cannabinoid agonists differentially affect mesolimbic dopamine release and related behaviors
https://pubmed.ncbi.nlm.nih.gov/38661670/
Mental Health & Substance Use Disorders
In non-western minority people of Europe, public health data found cannabis linked to a small increased risk for psychotic disorder
The contribution of cannabis use to the increased psychosis risk among minority ethnic groups in Europe
https://pubmed.ncbi.nlm.nih.gov/38721761/
And in current cannabis users, abnormalities in cue competition effects (a test related to psychosis)
Overshadowing and salience attribution in relation to cannabis use
https://www.sciencedirect.com/science/article/pii/S2215001324000167
Among male truck drivers in Nigeria, a variant of the CB1 receptor (rs806379 ) was associated with chronic polysubstance use
Association of Cannabinoid-Receptor 1 Gene with Chronic Polysubstance Use among Nigerian Male Commercial Motor Vehicle Drivers
https://www.researchgate.net/publication/380476158_Association_of_Cannabinoid-receptor_1_gene_with_Chronic_Polysubstance_Use_among_Nigerian_Male_Commercial_Motor_Vehicle_drivers
On the profiles linking cumulative lifetime violence with cannabis use disorder
Cumulative lifetime violence, social determinants of health, and cannabis use disorder post-cannabis legalization in a community sample of men: An intersectional perspective
https://pubmed.ncbi.nlm.nih.gov/38722053/
Hormones & Reproduction
A survey of Canadian mothers found that they thought of public health guidelines on cannabis as judgmental in tone, too focused on abstinence & ineffective in conveying useful information
Cannabis harm reduction: perspectives of women who use and allied social and health-care providers
https://www.tandfonline.com/doi/abs/10.1080/09687637.2024.2346655
On the perceptions of cannabis use among breastfeeding mothers, two-thirds were not concerned at all
Perceptions of Cannabis Use and Its Benefits and Risks Among Breastfeeding Mothers
https://www.liebertpub.com/doi/pdf/10.1089/whr.2024.0021
In a small study of three-year-olds exposed to substances prenatally, the males exposed to cannabis had the greatest neurodevelopmental language delays
Evaluation of three-year neurodevelopmental outcomes in infants prenatally exposed to substance use
https://pubmed.ncbi.nlm.nih.gov/38640866/
In public health data of pregnancy, prenatal cannabis & nicotine exposure was linked with an increased risk of infant & neonatal death
Risk of Adverse Neonatal Outcomes After Combined Prenatal Cannabis and Nicotine Exposure
https://pubmed.ncbi.nlm.nih.gov/38713462/#:~:text=Compared%20with%20nonusers%2C%20those%20with,and%2012.0%25%2C%20respectively).
On what young adults think about cannabis use during pregnancy
Perspectives of adolescents and young adults on cannabis use during pregnancy
https://pubmed.ncbi.nlm.nih.gov/38723313/
A review of studies on the motivations & effects of maternal cannabis use
Field Observations from Houston County Home Visit Pilot Program: Maternal Marijuana Use
https://digitalcommons.georgiasouthern.edu/gapha-conference/2024/2024/24/
In mice with learning & memory deficits from maternal separation, activating the GPR55 receptor (which may one day be known as CB3) while they are juveniles increased serotonin production & reduced deficits
Activation of GPR55 Ameliorates Maternal Separation-Induced Learning and Memory Deficits by Augmenting 5-HT Synthesis in the Dorsal Raphe Nucleus of Juvenile Mice
https://pubmed.ncbi.nlm.nih.gov/38799363/
In newborn rats exposed to a maternal high fat diets, fish oil supplementation during the pregnancy modulated the liver’s endocannabinoid system to help with the development of obesity & liver disease
Fish oil supplementation during pregnancy decreases liver endocannabinoid system and lipogenic markers in newborn rats exposed to maternal high-fat diet
https://pubmed.ncbi.nlm.nih.gov/38727803/
Musculoskeletal & Exercise
In an exercise test, three weeks of 150 milligrams of CBD per day did not change performance on a 10-minute bicycle test
Does a broad‐spectrum cannabidiol supplement improve performance in a 10‐min cycle ergometer performance‐test?
https://onlinelibrary.wiley.com/doi/pdf/10.1002/ejsc.12116
In a rat model of exercise, combining cannabis & the steroid stanozolol caused serious detrimental effects on heart tissue
Effect of Stanozolol and/or Cannabis Abuse on Hypertrophic Mechanism and Oxidative Stress of Male Albino Rat Cardiac Tissue in Relation to Exercise: A Sport Abuse Practice
https://pubmed.ncbi.nlm.nih.gov/38720122/
The Guts
In a mouse model of pain, the combination of paracetamol & the terpene beta-caryophyllene protected the guts as well as reducing inflammatory pain
Synergistic Antinociceptive Effect of β-Caryophyllene Oxide in Combination with Paracetamol, and the Corresponding Gastroprotective Activity
https://pubmed.ncbi.nlm.nih.gov/38790999/
The Heart
In mice, the terpene beta-caryophyllene lowered information to help with blood pressure regulation via the renin-angiotensin system
Angiotensinergic effect of β-Caryophyllene on Lipopolysaccharide- induced systemic inflammation
https://pubmed.ncbi.nlm.nih.gov/38744071/
The Lungs
In a rat model of acute respiratory distress syndrome, a drug that inhibits the MAGL enzyme (thus raising the levels of 2AG) reduced lung inflammation, cell death & tissue damage
The monoacylglycerol lipase inhibitor JZL184 and ARDS: Differential effects in direct and indirect rat models
https://assets-eu.researchsquare.com/files/rs-4363869/v1/0e30a24a-0c47-4654-a48a-df714c2b3a24.pdf?c=1715944945
The Genitourinary System
In rat bladder & vas deferens tissue, anandamide caused relaxation via the CB1 & CB2 as well as a potassium channel
The relaxation effect of endocannabinoid anandamide on isolated rat bladder and vas deferens tissues and possible mechanisms
https://pubmed.ncbi.nlm.nih.gov/38715461/
The Skin
In rat skin flaps, the terpene beta-caryophyllene improved survival via the reduction of pro-inflammatory cytokines & the inhibition of apoptosis (program cellular suicide)
β-Caryophyllene promotes the survival of random skin flaps by upregulating the PI3K/AKT signaling pathway
https://www.sciencedirect.com/science/article/abs/pii/S0944711324003854
Nanoemulsions with hemp seed oil & aloe vera gel
Optimization and Bioactive Properties of Nanoemulsion Formulated with Hemp (Cannabis sativa L.) Seed Oil and Aloe vera (Barbadensis miller Stockton) Gel
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.202305110
Cancer & Chemotherapy
In glioblastoma cells (the most aggressive brain cancer), CBD upregulated their stress granules (a type of membrane-less intracellular microstructures of biomolecular condensates)
Altering biomolecular condensates as a potential mechanism that mediates cannabidiol effect on glioblastoma
https://pubmed.ncbi.nlm.nih.gov/38713310/
In pancreatic cancer cells, CBD created toxicity via ceramides & endoplasmic reticulum stress
Cannabidiol's cytotoxicity in pancreatic cancer is induced via an upregulation of ceramide synthase 1 and ER stress
https://pubmed.ncbi.nlm.nih.gov/38720356/
In breast cancer cells, the ability of cannabinoids to cause cell death is helped by calcium overload in the mitochondria (powerhouse of the cell)
Mitochondrial calcium overload contributes to cannabinoid-induced paraptosis in hormone-responsive breast cancer cells
https://pubmed.ncbi.nlm.nih.gov/38721827/
On the anti-cancer effects of aqueous cannabis extracts
Aqueous Extracts of Cannabis sativa: Cytotoxicity and Effects on Angiogenesis, Oxidative Stress and Nitric Oxide Production
https://link.springer.com/article/10.1007/s40011-024-01561-z
Computer analysis of using cannabis leaves as a potential anti-cancer drug
In silico investigation of cannabinoids from Cannabis sativa leaves as a potential anticancer drug to inhibit MAPK-ERK signaling pathway and EMT induction
https://pubmed.ncbi.nlm.nih.gov/38716440/
Synthetic Cannabinoids
How the synthetic cannabinoid AMB-FUBINACA moves through rats
Determine the pharmacokinetics (half-life, volume of distribution and clearance) of AMB-FUBINACA in rats plasma using GC-MS / MS
https://pubmed.ncbi.nlm.nih.gov/38729531/
A thesis project on the metabolism of HHC & its stereoisomers
In silico, in vitro, and in vivo human metabolism of a new semi-synthetic cannabinoid: Hexahydrocannabinol (HHC) and its stereoisomers
https://iris.univpm.it/handle/11566/326478
On detecting HHC in oral fluid
Immunological detection of hexahydrocannabinol (HHC) in oral fluid
https://pubmed.ncbi.nlm.nih.gov/37916294/
Cool Chemistry & Tools
On using ionic liquids to improve CBD bioavailability
Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion
https://pubmed.ncbi.nlm.nih.gov/38823878/
On creating inverse agonists of the CB2 receptor
Teaching an Old Dog New Tricks for Achieving CB2-Selective Inverse Agonism
https://pubmed.ncbi.nlm.nih.gov/38799666/
An inverse agonist binds to a receptor but causes an opposite pharmacological response.
Thanks.
- lex
PS: For today’s Dixieland trumpet, Wingy Manone’s ‘Swinging Mainstream Sides’. Born in 1900 & nicknamed Wingy because he only had one arm after a streetcar accident at the age of 10 in his hometown of New Orleans, he used an artificial arm so adroitly that most of the public were unaware. During the ‘20s, he played trumpet & cornet with various bands until landing a gig on some early Benny Goodman records & becoming a sought-after musician for recording sessions. A master of hot jazz, his hit record ‘Tar Paper Stomp’ became the riff of Glen Miller’s infamous ‘In the Mood’. He spent decades touring & playing before his death in 1982.
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