C&P#111: Cannabinoids for the skin, for cancer & for dogs in pain
C&P#111: Cannabinoids for the skin, for cancer & for dogs in pain
Hemp feed for your chickens!
This week…
CBD & CBG protect skin from UV radiation
For the symptoms of cancer treatments, many studies on how cannabinoids help
Hemp extracts great for dogs with pain
86% of drug researchers admit to using drugs!
Legalizing cannabis lowered intimate partner violence levels?!
For improving the ability of CBD to kill breast cancer cells, add camel milk
FLASH: Rimonabant perhaps not linked to suicidality after all
For COVID, CBGA & CBDA strongest at lowering viral replication
Creating proteins that act like synthetic cannabinoids
Chart week!: Number of paper summaries that end with the phrase “(nice charts!)”: 6
(Papa Lex loves a good chart)One Surrealist film reference
Hello everyone,
Welcome to the 111th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science + assorted canna-news & psychedelic updates. On the cannabinoids, ask me anything.
Editor’s note:
Congrats to the 2 lucky winners to first find my Easter Egg a few weeks ago & who each received their choice of my Moby Dick pot books. Kudos for your keen eyes Annika M & William B. For anyone who missed out, buy the CROWN or SUNset here.
Free resources
CVResearch.info: the extensive cannabinoid science archive I maintain for CV Sciences
Read my free How-To Guides or watch my 3-Minute Cannabinoid Science videos on YouTube or read my canna-science journalism here
As always, here’s the Glossary of Cannabinoid Terms & at the bottom is the album of the week
For more… (my Linktree)
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Buy ‘SUNset’, my Queer cannabis history graphic novel or ‘The CROWN’, the story of the hunt for the structure of CBN. To see more about this series of canna-graphic novel series based on Moby Dick, see lexpelger.com
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Sponsor: CV Sciences introduces PlusHLTH!
Besides the new Reshape product for weight control that we’ve been talking about the last two weeks, now there is Clarity & Peace.
The Clarity gummies are for focus & cognitive support. They contain…
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The Peace gummies are for stress relief & improved mood. They contain…
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Lemon Balm
Holy Basil
St. John’s Wort
Use the coupon code “LEX” for 30% off!
My work this week:
My Vids:
(@lexpelgerandhisbooks or on YouTube)
The Lamed Wufniks (from Borges) (I fucked up the pronunciation, but this is a spiritual idea that I’ve never forgotten)
AI Agents (I’m on a mission to get Pocket to hire me as their TikTok host)
My Year of Foundations (a personal update)
Ways to support this work:
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Best Of Cannabinoid Science...
86% of drug researchers admit to using drugs!
https://www.marijuanamoment.net/vast-majority-of-drug-researchers-acknowledge-having-used-drugs-themselves-study-finds-but-far-fewer-feel-comfortable-discussing-it
" He's used drugs - he's biased! He's not a drug user - what would he know!": A cross-sectional, online study of drug researchers' experiential knowledge of drug use and disclosure
https://pubmed.ncbi.nlm.nih.gov/39100987/
I bet that number is even higher for us drug writers.
A new assessment tool for anesthesiologists for assessing cannabis use
Enhancing the Preanesthesia Evaluation: Consensus Development of the Cannabis Use and Behaviors Assessment Tool (CUBAT)
https://pubmed.ncbi.nlm.nih.gov/38935007/
Clinical
In people with anxiety, they reported CBD helped the most with subjective anxiety, difficulty falling asleep & irritability
Cannabidiol (CBD) Products: Use Patterns and Perceptions Within a Sample of Anxious Users
https://www.tandfonline.com/doi/full/10.1080/10826084.2024.2369153
“These findings were despite the fact that the most frequent dosing levels (∼50mg) were well below those empirically observed to yield anxiolytic effects. Most participants denied side effects, adding to the literature supporting CBD products’ safety and tolerability.”
In people with chronic musculoskeletal pain, a survey found that the majority of cannabis users found it to be “very” or “somewhat effective” for pain
Understanding the epidemiology and perceived efficacy of cannabis use in patients with chronic musculoskeletal pain
https://link.springer.com/article/10.1186/s42238-024-00231-1
Public health data on the use of cannabis among youth & adults from 2013 to 2022 found levels increased for adults but not for young people
Prevalence of and trends in current cannabis use among US youth and adults, 2013–2022
https://www.sciencedirect.com/science/article/pii/S2772724624000374
For prenatal cannabis exposure & autism, a big public health data analysis found that no link
Examining the association between prenatal cannabis exposure and child autism traits: A multi-cohort investigation in the environmental influences on child health outcome program
https://onlinelibrary.wiley.com/doi/abs/10.1002/aur.3185
There are certainly other studies that have found a link (including public health data & preclinical research) but work like this suggests that if the link does exist, it must not be that strong.
On intimate partner violence, a thesis project analyzes public health data to find the legalization of adult use cannabis resulted in a substantial decrease in rates of intimate partner violence
THE IMPACT OF RECREATIONAL MARIJUANA LEGALIZATION ON INTIMATE PARTNER VIOLENCE
https://repository.library.georgetown.edu/bitstream/handle/10822/1088803/Baldwin_georgetown_0076M_15972.pdf?sequence=1
In a unique if not altogether earth shattering study, in a double-blind trial of dancers treated with probiotics for 3 months, they had no alterations to their CB2 or FAAH levels & had no effects on pain or fatigue but it did improve sleep quality
Evaluating the Impact of Probiotic Therapy on the Endocannabinoid System, Pain, Sleep and Fatigue: A Randomized, Double-Blind, Placebo-Controlled Trial in Dancers
https://pubmed.ncbi.nlm.nih.gov/38891799/
In overweight people, a combination of hemp protein supplements & aerobic exercise improved their health status, cholesterol, HDL, LDL & amino acid levels in the plasma,
Mediterranean Diet Combined with Regular Aerobic Exercise and Hemp Protein Supplementation Modulates Plasma Circulating Amino Acids and Improves the Health Status of Overweight Individuals
https://pubmed.ncbi.nlm.nih.gov/38892526/
In dogs with pain, full spectrum hemp extracts lowered their pain scores, increased their ability to use stairs, improved daily activity & lowered blood levels of proinflammatory cytokines
Efficacy and tolerability of full spectrum hemp oil in dogs living with pain in common household settings
https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2024.1384168/full
Harms
For cannabinoid drug-drug interactions, a review of 31 reports where cannabinoids produced adverse events or altered drug pharmacokinetics (how they move through the body)
Systematic review of drug-drug interactions of delta-9-tetrahydrocannabinol, cannabidiol, and Cannabis
https://pubmed.ncbi.nlm.nih.gov/38868665/
“Interactions between cannabis/cannabinoids and warfarin, valproate, tacrolimus, and sirolimus were the most widely reported and may pose the greatest risk to patients. Common ADRs included bleeding risk, altered mental status, difficulty inducing anesthesia, and gastrointestinal distress. Additionally, we identified 18 instances (58%) in which clinicians uncovered an unexpected serum level of the prescribed drug.”
In trauma patients, cannabis use was linked to increased platelet activation (which is linked to increased blood clots in the veins)
Marijuana may lead to increased platelet activity in trauma patients
https://www.americanjournalofsurgery.com/article/S0002-9610(24)00374-X/abstract
In early adolescence, prenatal cannabis exposure linked to differences in gray & white matter levels, resting state connectivity & increased symptoms of attention problems & ADHD
Prenatal cannabis exposure, the brain, and psychopathology during early adolescence
https://www.nature.com/articles/s44220-024-00281-7
In older adults who had an operation, cannabis use was associated with increased postoperative pain levels & opioid doses
Cannabis use and acute postoperative pain outcomes in older adults: a propensity matched retrospective cohort study
https://rapm.bmj.com/content/early/2024/06/27/rapm-2024-105633
A review of the abuse & safety risks of natural & synthetic cannabinoids
A critical assessment of the abuse, dependence and associated safety risks of naturally occurring and synthetic cannabinoids
https://pubmed.ncbi.nlm.nih.gov/38915848/
For cannabis use disorder, a meta-analysis of surveys put it at 2.5% of the population
Prevalence of Cannabis Use Disorder: A Meta-Analysis of Population Surveys
https://pubmed.ncbi.nlm.nih.gov/38922583/
And German public health data showed an increase in cannabis use disorder since 2000
Cannabis-related treatment demand at the eve of German cannabis legalization – a 20-years trend analysis
https://link.springer.com/article/10.1007/s00406-024-01832-w
And in young people diagnosed with cannabis use disorder, they had a lower risk of going to the hospital for pulmonary embolisms but if they did, they tended to stay in the hospital longer & with a higher cost
Association of Cannabis Use Disorder With Hospitalizations for Pulmonary Embolism and Subsequent in-Hospital Mortality in Young Adults: A Contemporary Nationwide Analysis
https://pubmed.ncbi.nlm.nih.gov/38934855/
In young people, cumulative depression linked with cannabis use disorder
The longitudinal association of cumulative depression with cannabis use disorder among young adults
https://pubmed.ncbi.nlm.nih.gov/38900055/
Also, this is a sane reaction to an insane world. When I got back from my first-year long trip in a poverty-stricken country, I spent a few months smoking heavily to figure out what the fuck is happening in this world.
An evaluation of lenabasum (a CB2 drug) showed that at higher levels, it did cause “drug linking” effects & thus had some abuse potenital
Evaluating the Abuse Potential of Lenabasum, a Selective CB2 Cannabinoid Receptor Agonist
https://pubmed.ncbi.nlm.nih.gov/38936978/
In human eggs, THC altered the regulation of hundreds of genes & in the humans undergoing IVF, testing positive for THC reduced the chance of reproductive success
Cannabis negatively impacts female fertility: an in vitro and clinical investigation
https://academic.oup.com/humrep/article/39/Supplement_1/deae108.641/7703848
Reviews
This week’s Hot Take: according to a re-analysis, these researchers found that the data on the notorious rimonabant (a blocker of the CB1 receptor that was pulled by the FDA, causing a cannabinoid research winter) does “not support the FDA's conclusion that the use of rimonabant was associated with an increase in the risk of suicidality”
Seventeen years since rimonabant's downfall: reassessing its suicidality risk profile
https://pubmed.ncbi.nlm.nih.gov/38887179/
Too bad I’m taking a pause from doing my graphic novels this year, because I have a mostly completed chapter on the history of pharmaceutical cannabinoids & it’s culmination is the FDA’s decision to pull rimonabant.
A review of 47 MRI studies on how cannabis alters neurocognition
Effects of Cannabis Use on Neurocognition: A Scoping Review of MRI Studies
https://www.tandfonline.com/doi/abs/10.1080/02791072.2024.2372377
In neurodegenerative disease, a review of how cannabinoids modulate the immune system (with nice charts!)
Cannabinoids' Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases
https://pubmed.ncbi.nlm.nih.gov/38928109/
For postoperative pain, a review of using cannabinoids for analgesia (with nice charts!)
Cannabinoid Analgesia in Postoperative Pain Management: From Molecular Mechanisms to Clinical Reality
https://pubmed.ncbi.nlm.nih.gov/38892456/
For strokes, a review on the therapeutic potential of using CBD (with nice charts!)
Potential of CBD Acting on Cannabinoid Receptors CB1 and CB2 in Ischemic Stroke
https://pubmed.ncbi.nlm.nih.gov/38928415/
A review of the anti-cancer properties of CBD (with nice charts!)
Anti-Cancer and Anti-Proliferative Potential of Cannabidiol: A Cellular and Molecular Perspective
https://pubmed.ncbi.nlm.nih.gov/38891847/
For acute inflammatory pain, a review of using transdermal CBD (with nice ECS skin charts!)
Transdermal Delivery of Cannabidiol for the Management of Acute Inflammatory Pain: A Comprehensive Review of the Literature
https://pubmed.ncbi.nlm.nih.gov/38892047/
For gut health, a review of how cannabinoids alter intestinal motility, barrier permeability & a look at their therapeutic potential (with nice charts!)
Effects of Cannabinoids on Intestinal Motility, Barrier Permeability, and Therapeutic Potential in Gastrointestinal Diseases
https://pubmed.ncbi.nlm.nih.gov/38928387/
For chronic pain, a review of using PEA
Practical update on oral palmythopylethanolamide (PEAum) in the management of chronic pain. Narrative review
https://www.mpainjournal.com/actualizacion-practica-sobre-la-palmitoiletanolamida-peaum-oral-en-el-manejo-del-dolor-cronico-revision-narrativa1163
For respiratory infections, a review of CBD as an anti-inflammatory treatment [in Portuguese]
Cannabidiol como um potencial tratamento anti-inflamatório na infecção respiratória (revisão integrativa)
https://ojs.europubpublications.com/ojs/index.php/ced/article/view/4642
For cannabis & the liver, a review of the mixed findings of help vs harm
Tobacco, cannabis, and the liver
https://pubmed.ncbi.nlm.nih.gov/38872776/
A review of the interactions between drugs targeting the CB1 receptor & a glutamate receptor (the most common excitatory neurotransmitter)
Interactions between metabotropic glutamate and CB1 receptors: implications for mood, cognition, and synaptic signaling based on data from mGluR and CB1R-targeting drugs
https://link.springer.com/article/10.1007/s43440-024-00612-6
In the retina, a review of how the endocannabinoids modulate their circadian rhythm
Dynamic endocannabinoid-mediated neuromodulation of retinal circadian circuitry
https://www.sciencedirect.com/science/article/abs/pii/S1568163724002198
Preclinical
In a rat model of heart damage from cancer treatment, CBD oil lowered cardiac enzymes & inflammatory markers as well as acting as an antioxidant
Eventual Medicinal Benefits of Cannabidiol Oil alleviates Doxorubicin Related Cardiac injuries
https://bfszu.journals.ekb.eg/article_363502_a4a4de8a4c150db7bca3988d683849a9.pdf
In a model of Alzheimer's disease, CBN prevented dysfunctions of the mitochondria & endoplasmic reticulum (protein transportation & folding center)
Cannabinerol Prevents Endoplasmic Reticulum and Mitochondria Dysfunctions in an In Vitro Model of Alzheimer's Disease: A Network-Based Transcriptomic Analysis
https://pubmed.ncbi.nlm.nih.gov/38920643/
In an adolescent rat model of opioid use disorder, CBD protected against relapse in males but not females
Cannabidiol Protects against the Reinstatement of Oxycodone-Induced Conditioned Place Preference in Adolescent Male but Not Female Rats: The Role of MOR and CB1R
https://pubmed.ncbi.nlm.nih.gov/38928357/
In mice, cannabis extracts caused antidepressant & anti-inflammatory effects
In Vitro and In Vivo Anti-Inflammatory and Antidepressant-like Effects of Cannabis sativa L. Extracts
https://pubmed.ncbi.nlm.nih.gov/38931051/
In a tissue model of gastrointestinal inflammation, CBD, CBDV & CBG protected against increases in permeability
Selected phytocannabinoids inhibit SN-38- and cytokine-evoked increases in epithelial permeability and improve intestinal barrier function in vitro
https://www.sciencedirect.com/science/article/pii/S0887233324001188
In skin stem cells exposed to UVB, a full-spectrum CBD topical reduced cell death & inhibited inflammatory markers
Full-spectrum cannabidiol reduces UVB damage through the inhibition of TGF-β1 and the NLRP3 inflammasome
https://pubmed.ncbi.nlm.nih.gov/38958000/
And in skin cells & skin stem cells, topical CBD & CBG reduced UVA radiation’s inflammation & oxidation effects
Modulation of Redox and Inflammatory Signaling in Human Skin Cells Using Phytocannabinoids Applied after UVA Irradiation: In Vitro Studies
https://pubmed.ncbi.nlm.nih.gov/38891097/
For the virus of COVID-19, CBGA & CBDA were the strongest cannabinoids for lowering viral replication
Exploring Cannabinoids as Potential Inhibitors of SARS-CoV-2 Papain-like Protease: Insights from Computational Analysis and Molecular Dynamics Simulations
https://pubmed.ncbi.nlm.nih.gov/38932170/
In mice, the intoxication caused by THC was roughly equivalent to its main metabolite (breakdown product in the body) 11-OH-THC
The Intoxication Equivalency of 11-Hydroxy-Δ9-tetrahydrocannabinol (11-OH-THC) Relative to Δ9-tetrahydrocannabinol (THC)
https://pubmed.ncbi.nlm.nih.gov/38858091/
An analysis of using hemp leaves for treating conditions related to oxidative stress
The Potential of Hemp Extracts to Modify the Course of Oxidative-Stress Related Conditions
https://pubmed.ncbi.nlm.nih.gov/38931062/
There's a long human history of using the leaves of cannabis as a medicine.
the Headlines & Fav Articles
FDA approves hemp seed meal for egg-laying hens
https://www.marijuanamoment.net/fda-proposal-to-allow-hemp-seed-meal-as-food-for-egg-laying-hens-is-approved
The benefits of hemp for hens is a hot area of research & I usually see a new paper on this every week or two. In fact, there’s no hen research this week, but there’s a half dozen studies below on hemp as an animal feed.
A survey of healthcare providers of the Department of Veterans Affairs felt knowledgeable about their state cannabis laws but unsure whether they could discuss cannabis with their patients
VA Providers' Perceptions of Cannabis Use Policies in a Legalized and Nonlegalized State
https://pubmed.ncbi.nlm.nih.gov/38597903/
The Rise of the Cannabis Insanity Defense Across America
https://cannabislaw.report/article-weedsanity-the-rise-of-the-cannabis-insanity-defense-across-america/
“The “cannabis made me do it” defense, once a bizarre footnote in legal history, is gaining alarming traction in courtrooms across the globe. When Bryn Spejcher, a California woman, successfully used “transient psychosis” as her get-out-of-jail-free card after brutally stabbing her boyfriend 108 times, it set a dangerous precedent. I warned then that this ruling would open the floodgates for more killers to claim “temporary insanity” induced by cannabis use. Sadly, that prediction is becoming reality. In Ireland, Diego Costa Silva was found not guilty of murdering his wife, thanks to a “cannabis-induced psychosis” defense.”
In the Virgin Islands, Marcus ‘Young Blood’ Mark wins the Calypso Crown with the song “The Miseducation of Marijuana”
https://cannabislaw.report/bv-tortola-young-blood-wins-calypso-crown-with-cannabis-education-songs/
History Corner: on hemp & linen as the characteristic material of bookbindings from the 16th to 18th century in a Venetian library
Study and characterization of paper bookbindings from 16 to 18th stored in the Marciana National Library
https://heritagesciencejournal.springeropen.com/articles/10.1186/s40494-024-01339-6
International
In China, CBD now classified into the “precursor chemicals management system”, which seems to mean a path forward for nationwide production
https://mjbizdaily.com/united-states-alerts-hemp-sector-to-new-chinese-cbd-regulations/
In the Netherlands, the cannabis growers are having trouble meeting the new regulation standards
https://www.themayor.eu/en/a/view/dutch-cannabis-growers-have-trouble-meeting-regulation-standards-12689
Italy approved a crackdown on “light cannabis” (though this article doesn’t make it clear what exactly that means)
https://www.ansa.it/sito/notizie/politica/2024/08/01/seduta-fiume-sul-ddl-sicurezza-arriva-stretta-su-cannabis_074544e5-38d5-4aa3-af8b-f8013a49b63b.html
Germans leaning into intoxicating hemp-derived cannabinoids!
https://cannabislaw.report/hemp-derived-cannabinoids-battle-reaches-german-shores
#loopholesforthewin
In Thailand, how the density of cannabis outlets alters consumer cannabis use behaviors
Density of cannabis outlets vs. cannabis use behaviors and prevalent cannabis use disorder: findings from a nationally-representative survey
https://pubmed.ncbi.nlm.nih.gov/38699183/
“The prevalence of current cannabis use was 15 percent. At a 400-m radius, participants who reported three cannabis outlets had 4.2 times higher odds of being current users than participants who reported no outlet... We found no association between outlet density and hazardous cannabis use or cannabis use disorder.”
In Brazil, an analysis of ways to improve medical cannabis access
The Impact of Associations on Accessibility of Medicinal Cannabis in Brazil Looking at Fasciculated Roots of Policy and Access to Products
https://www.researchgate.net/publication/381845196_The_Impact_of_Associations_on_Accessibility_of_Medicinal_Cannabis_in_Brazil_Looking_at_Fasciculated_Roots_of_Policy_and_Access_to_Products
From the new book, ‘Cannabis: Cultures and Markets’…
On the cannabis subcultures of Nigeria
Cannabis subculture, community forming and socio-structural challenges in Nigeria
https://www.taylorfrancis.com/chapters/edit/10.4324/9781003468967-4/cannabis-subculture-community-forming-socio-structural-challenges-nigeria-ugochukwu-ugwu-emeka-dumbili
And in Mexico, on the cultural stigmatization & police corruption
Cultural stigmatization and police corruption: cannabis, gender, and legalization in Mexico
https://www.taylorfrancis.com/chapters/edit/10.4324/9781003468967-7/open-access-cultural-stigmatization-police-corruption-cannabis-gender-legalization-mexico-carolina-agoff-gustavo-fondevila-sveinung-sandberg
In Thailand, using Twitter to assess the type & availability of cannabis products
Exploring Twitter chatter to assess the type and availability of cannabis-related products in Thailand
https://www.tandfonline.com/doi/full/10.1080/15332640.2024.2367253
The Laws, The War on Drugs & the End of Prohibition
From 2011 to 2021, over 300k kids lost a parent to a drug overdose
https://nida.nih.gov/news-events/news-releases/2024/05/more-than-321000-us-children-lost-a-parent-to-drug-overdose-from-2011-to-2021
Estimated Number of Children Who Lost a Parent to Drug Overdose in the US From 2011 to 2021
https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2818228
#EndTheDrugWar! #HarmReduction #SupervisedConsumptionServices
The DPA released a white paper on the harms of Drug War surveillance & dragnets
Drug War Dragnet: Surveillance, Criminalization, and Drug War Logic within and beyond Community Supervision
https://drugpolicy.org/wp-content/uploads/2024/06/fsr.2024.36.4.188.pdf
Also, this is a great organization to support with your donations.
#EndTheFuckingDrugWarAlready
In Mexico, an analysis suggests that drug-related detentions are linked to increased drug-related violence
The Connection Between Drug-Related Detentions and Drug-Related Violence: Another Failure of the War on Drugs in Mexico
https://www.tandfonline.com/doi/abs/10.1080/01639625.2024.2372421
UK gangs using empty shops & pubs for illegal cannabis grows
https://www.bbc.com/news/articles/c2x0x6ypgneo
NIDA scientists suggest using taxes to reduce cannabis use (boo!)
Tax Policy—An Understudied Approach to Reducing Cannabis Use
https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2820769
This plant is already taxed to death.
For driving, a review of seven studies found mixed results on the impact of adult-use cannabis legalization on emergency department visits for traffic injuries
Road hazard: a systematic review of traffic injuries following recreational cannabis legalization
https://link.springer.com/article/10.1007/s43678-024-00736-x
“Four of the studies included reported increases in traffic injuries after legalization, while the remaining three studies found no significant change.”
In Indonesia, on using drones to identify illegal cannabis grows (boo!)
Images Processing of Unmanned Aerial Vehicle (UAV) for Cannabis Identification
https://www.researchgate.net/publication/381742328_Images_Processing_of_Unmanned_Aerial_Vehicle_UAV_for_Cannabis_Identification
Psychedelics, Plant Medicines & Other Psychoactives
On the Stoned Ape Theory of Terrence McKenna, a new multidisciplinary study offers some support
https://doubleblindmag.com/terence-mckenna-might-have-been-right-about-the-stoned-ape-theory-new-research-says
Inside the lab at The Farm where Sasha Shulgin synthesized many of his creations
https://doubleblindmag.com/inside-sasha-shulgins-lab/
After his death, but before the passing of Ann, I got to spend one lovely gathering day at The Farm.
The Psychoactive Research
A survey found that mystical psychedelic experiences reduced cannabis use & improved psychological flexibility
Significant Psychedelic Experiences Evaluated for Mystical Characteristics Associated with Cannabis Use Reduction and Psychological Flexibility Improvement: A Naturalistic Cross-Sectional Retrospective Survey
https://www.tandfonline.com/doi/abs/10.1080/02791072.2024.2375720
A survey of the characteristics of psychedelic users around the world
The Global Psychedelic Survey: Consumer characteristics, patterns of use, and access in primarily anglophone regions around the world
https://pubmed.ncbi.nlm.nih.gov/38936219/
In this thesis project in people with fibromyalgia, a survey reported help with reducing acute pain & a decreased need for pain medications
Use Of Psilocybin And Other Classic Psychedelics In Fibromyalgia: A Survey Study
https://digitalcommons.library.uab.edu/etd-collection/3845/
For depression & substance use disorders, a review of psychedelic therapy
Psychedelic therapy in depression and substance use disorders
https://pubmed.ncbi.nlm.nih.gov/38773750/
For depression, a review of psilocybin’s molecular underpinnings
Psilocybin Therapy for Depression: A Review of Current Molecular Knowledge
https://www.scienceopen.com/hosted-document?doi=10.61833/JNST.2024.0002
In a mouse model of depression, psilocybin caused a rapid antidepressant effect via the promotion of neuroplasticity
Psilocybin promotes neuroplasticity and induces rapid and sustained antidepressant-like effects in mice
https://pubmed.ncbi.nlm.nih.gov/38680011/
In a rat model of depression, psilocybin increased their bias towards optimism
Psilocybin increases optimistic engagement over time: computational modelling of behavior in rats
https://www.biorxiv.org/content/10.1101/2024.05.16.594614v1.abstract
“The model revealed that rats treated with psilocybin achieve more rewards through increased task engagement, mediated by modification of forgetting rates and reduced loss aversion. These findings suggest that psilocybin may afford an optimism bias that arises through altered belief updating, with translational potential for clinical populations characterised by lack of optimism.”
In a rat model of alcohol use disorder, psilocybin reduced intake via serotonin & potentially dopamine receptors in the left nucleus accumbens (a brain region related to addiction)
Psilocybin reduces alcohol self-administration via selective left nucleus accumbens activation in rats
https://pubmed.ncbi.nlm.nih.gov/38703387/
In a rat model of PTSD, MDMA altered neuroinflammatory markers & oxytocin signaling
Examining the Role of Oxytocinergic Signaling and Neuroinflammatory Markers in the Therapeutic Effects of MDMA in a Rat Model for PTSD
https://pubmed.ncbi.nlm.nih.gov/39065697/
In a mouse model of acute stress, the behavioral changes caused by ketamine are linked to changes in synaptic signaling mechanisms
Distinct synaptic mechanisms drive the behavioral response to acute stress and rapid correction by ketamine
https://www.nature.com/articles/s41386-024-01908-0
The Plant & the History
Growing, Farming & Processing
On lessons of hemp production from small-scale Italian & Swiss growers
What can we learn from low-THC cannabis growers in Europe? A comparative transnational study of small-scale cannabis growers from Italy and Switzerland
https://www.sciencedirect.com/science/article/pii/S0955395924001907
In Maryland, a thesis project on hemp fiber production recommendations
PRODUCTION RECOMMENDATIONS FOR INDUSTRIAL HEMP (CANNABIS SATIVA) FOR FIBER PRODUCTION IN MARYLAND: OPTIMIZING PLANTING DATE FOR FIBER YIELD, QUALITY, AND WEED MANAGEMENT
https://drum.lib.umd.edu/items/6eae0a16-e366-41cb-9519-7ea3f9c95233
On increasing greenhouse lighting for better cannabis production
Supplemental greenhouse lighting increased the water use efficiency, crop growth, and cutting production in Cannabis sativa
https://pubmed.ncbi.nlm.nih.gov/38911978/
And the benefits of certain far-red light treatments
Far Out! – the effects of far-red light on Cannabis
https://assets-eu.researchsquare.com/files/rs-4567555/v1/4bab1f99-728a-41e0-b678-2874b6c32e4e.pdf?c=1719806542
And on decreasing blue light to increase efficacy for more cost effective production
CANNABIS LIGHTING: DECREASING BLUE PHOTON FRACTION INCREASES YIELD BUT EFFICACY IS MORE IMPORTANT FOR COST EFFECTIVE PRODUCTION OF CANNABINOIDSA
https://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=1236&context=etd2023#page=36
On the effects of fungicides on the microbiome of CBD-rich cannabis plants
Influence of Fungicide Application on Rhizosphere Microbiota Structure and Microbial Secreted Enzymes in Diverse Cannabinoid-Rich Hemp Cultivars
https://pubmed.ncbi.nlm.nih.gov/38892079/
In Oregon, the first report of the parasitic worm Meloidogyne hapla
First report of Meloidogyne hapla on hemp (Cannabis sativa) in Oregon
https://agris.fao.org/search/en/providers/122436/records/662908dd2b3930d7cdc0969e
In cloned cannabis populations, an analysis of methylation (the turning off of genes with a methyl group) was found to be preserved across the tissue cultures which is good news for the consistency & reliability of medical cannabis
Comparative restriction enzyme analysis of methylation (CREAM) reveals methylome variability within a clonal in vitro cannabis population
https://pubmed.ncbi.nlm.nih.gov/38872884/
Food & Nutrition
In hemp tea, a thesis project analyzing their elemental composition
Elemental content in hemp-based herbal teas by ICP-MS
https://iris.uniroma1.it/handle/11573/1713958
In lambs fed hemp, THC did collect in some tissue, especially the fat
Cannabinoid residuals in tissues of lambs fed spent hemp biomass and consumer's exposure assessment
https://www.sciencedirect.com/science/article/abs/pii/S0278691524004149
For cow feed, a comparison of essential oil effects between sativa & indica dominant cannabis on the microbiome, rumen fermentation & methane production
Comparison of the Effects of Essential Oils from Cannabis sativa and Cannabis indica on Selected Bacteria, Rumen Fermentation, and Methane Production-In Vitro Study
https://pubmed.ncbi.nlm.nih.gov/38892045/
For goats, adding CBD to their feed improved immune cell factors, meat quality & tenderness without adverse impacts on growth
Effects of Hemp-Derived Cannabidiol Supplementation on Blood Variables, Carcass Characteristics, and Meat Quality of Goats
https://pubmed.ncbi.nlm.nih.gov/38929337/
In animals fed spent hemp, it caused very little alterations to their liver metabolism profiles
Liver Transcriptomic Profiles of Ruminant Species Fed Spent Hemp Biomass Containing Cannabinoids
https://pubmed.ncbi.nlm.nih.gov/39062742/
On harvesting pectin (a soluble fiber widely used in foods) from leftover hemp biomass
Effect of Organic Acid-Aided Extraction on Characteristics and Functional Properties of Pectin from Cannabis sativa L
https://pubmed.ncbi.nlm.nih.gov/38893387/
A review of hemp seed proteins & their high nutritional value
Hempseed protein-derived short- and medium-chain peptides and their multifunctional properties
https://pubmed.ncbi.nlm.nih.gov/38906589/
Industrial Use
On creating food packaging films with CBD for hydrophobicity, antioxidant capacity & antibacterial activity
Development and characterization of pectin-based composite film incorporated with cannabidiol/2,6-di-O-methyl-β-cyclodextrin inclusion complex for food packaging
https://www.sciencedirect.com/science/article/abs/pii/S0141813024043307
On using hemp waste to produce thermal insulation
Use of Waste Raw Materials in the Form of Hemp Shives and Waste Sheep Wool to Produce Composites Dedicated to Thermal Insulation
https://www.tandfonline.com/doi/full/10.1080/15440478.2024.2371902
For polyurethane foams, increasing their flame-dampening properties with hemp seed oil
Harnessing Enhanced Flame Retardancy in Rigid Polyurethane Composite Foams through Hemp Seed Oil-Derived Natural Fillers
https://pubmed.ncbi.nlm.nih.gov/38891530/
On making sustainable yarn from hemp & recycled wool
Development of Sustainable Yarns from an Innovative Combination of European Hemp and Pure Recycled Wool
https://cdatp.journals.qucosa.de/cdatp/article/view/102
A thesis project on using hemp to remove lithium from the soil
Experimental approach for evaluating the ability of hemp (Cannabis sativa L.) to tolerate and phytoextract lithium from environmental matrices
https://iris.uniroma1.it/handle/11573/1714064
A review of the many industrial uses of hemp, especially for phytoremediation & bioenergy
Industrial Hemp As a Multi-Purpose Crop: Last Achievements and Research in 2018−2023
https://www.tandfonline.com/doi/pdf/10.1080/15440478.2024.2369186
CANNABINOID SCIENCE
5 reviews of the basics of cannabinoid medicine:
A review of how cannabinoids became therapeutic in the US
The Development of Cannabinoids as Therapeutic Agents in the United States
https://pubmed.ncbi.nlm.nih.gov/38849155/
And a review of 21 assessments on the clinical use of cannabis
Meaningfully Characterizing Cannabis Use for Research and Clinical Settings: A Comprehensive Review of Existing Measures and Proposed Future Directions
https://pubmed.ncbi.nlm.nih.gov/38883882/
And a Polish review of cannabinoids for treating epilepsy, pain & neural disorders
The Use of Compounds Derived from Cannabis sativa in the Treatment of Epilepsy, Painful Conditions, and Neuropsychiatric and Neurodegenerative Disorders
https://pubmed.ncbi.nlm.nih.gov/38891938/
And a Moroccan review of the chemical complexity & healing abilities of cannabis
In the weeds: A comprehensive review of cannabis; its chemical complexity, biosynthesis, and healing abilities
https://www.sciencedirect.com/science/article/pii/S2214750024000684
And an editorial on clinically targeting the endocannabinoidome
Editorial: Insights on cannabinoid translational science and medicine: the endocannabinoidome as a target for clinical practice
https://pubmed.ncbi.nlm.nih.gov/38887370/
Public Health
In cannabis research, opportunities for queer & trans youth-led research projects
Barriers and opportunities in community-led cannabis research: Group reflections from a queer and trans youth-led research project
https://pubmed.ncbi.nlm.nih.gov/38937198/
A call for better regulation of the cannabis gray market
The Cannabis Gray Market: A Case for Cannabis Regulatory Science Research
https://www.liebertpub.com/doi/abs/10.1089/can.2023.0278
According to US public health data, state legalization led to increased adult usage, especially in rural areas
Rural and urban differences in marijuana use following passages of medical marijuana laws
https://www.sciencedirect.com/science/article/pii/S0033350624002324
Among allergists & allergy patients, a survey of their cannabis knowledge & practice
Comparison of cannabis knowledge, attitudes, and practice between allergists and patients with allergies and asthma
https://pubmed.ncbi.nlm.nih.gov/38879163/
Characterizing the cannabis medical products of Portugal
Characterisation of Cannabis-Based Products Marketed for Medical and Non-Medical Use Purchased in Portugal
https://pubmed.ncbi.nlm.nih.gov/38930803/
Adolescents & Young Adults
From a special edition of the journal ‘Cannabis’ focused on young people, in college students…
the relationship between social anxiety & cannabis problems
Examining the Relation Between Social Anxiety and Cannabis Problems Among College Students Through Coping-Related Expectancies and Motives
https://pubmed.ncbi.nlm.nih.gov/38883283/
the effects of perceived risk on cannabis use & negative outcomes
General and Domain-Specific Perceived Risk Demonstrate Unique Associations with Cannabis Use, Negative Outcomes, and Motivation to Change among Undergraduate Students
https://pubmed.ncbi.nlm.nih.gov/38883284/
on how their cannabis use disorder is influenced by anxiety & an avoidant coping style
The Influence of Anxiety and Avoidant Coping on Probable Cannabis Use Disorder
https://pubmed.ncbi.nlm.nih.gov/38883279/
on how lowering their tendency to ruminate reduced problematic cannabis use
Examination of Rumination's Mediating Role in the Relation Between Distal Personality Predictors, Cannabis Coping Motives, and Negative Cannabis-Related Consequences
https://pubmed.ncbi.nlm.nih.gov/38883285/
how self-control correlates to cannabis use
Correlates of Cannabis Use and Self-Control Across a Diverse Sample of College Students: 2020-2022
https://pubmed.ncbi.nlm.nih.gov/38883282/
how heavy drinking & blackouts relate to their cannabis use
The Interaction of Cannabis Consumption with Heavy Episodic Drinking and Alcohol-induced Blackouts in Relation to Cannabis Use Consequences Among Recent Undergraduate College Cannabis Users
https://pubmed.ncbi.nlm.nih.gov/38883276/
how violating their university drug policy is linked to higher levels of cannabis use
Risk Factors for Quantity of Cannabis Use Per Day among College Students Who Violated Their University Drug Use Policy
https://pubmed.ncbi.nlm.nih.gov/38933496/
how their health status modulates the relationship between their depressive symptoms & cannabis vaping
The Moderating Role of Health Status on the Association Between Depressive Symptoms and Cannabis Vaping
https://pubmed.ncbi.nlm.nih.gov/38883281/
the relationship between their mental health during the pandemic & their cannabis use
Cannabis And College Students: Self-Perceived Mental Health Prior to, During, and After the Pandemic
https://pubmed.ncbi.nlm.nih.gov/38883278/
the characteristics & consequences of those who use alcohol & cannabis simultaneously
Latent Classes of Simultaneous Alcohol and Cannabis Use and Associations with Consequences using Daily Data
https://pubmed.ncbi.nlm.nih.gov/38883280/
In young adults, they naturally mature out of high risk substance use patterns but the most high risk factor is simultaneous alcohol & cannabis use
Simultaneous use of alcohol and cannabis and attenuated age-related declines in alcohol and cannabis use disorder symptoms across young adulthood
https://www.sciencedirect.com/science/article/pii/S2772724624000362
And in Black & Hispanic adolescent females in New York City, the risk of tobacco & cannabis co-use leading to substance use problems
Tobacco-Cannabis Co-use and Risk of Substance Use Problems Among Black and Hispanic Adolescent and Young Adult Females in New York City
https://link.springer.com/article/10.1007/s11469-024-01355-4
In college students with ADHD, a diary study showed a strong drive to use cannabis to cope with negative emotions
ADHD and Cannabis Use in College Students: Examining Indirect Effects of Coping Motives
https://drum.lib.umd.edu/items/fda2747f-2055-45e1-9186-c516934608d4
In Canada, a survey of the knowledge of young adults about cannabis
Youth and Young Adults’ Knowledge and Perceptions of Risks and Benefits Regarding Cannabis Products: A Cross-Sectional Analysis of Over 1,700 Individuals
https://www.tandfonline.com/doi/full/10.1080/02791072.2024.2371028
A thesis project in youth who have experienced psychosis on their risks & reasons for cannabis use
“If somebody takes the time to listen”: Understanding the risks and reasons for cannabis use among youth who have experienced psychosis
https://scholars.wlu.ca/etd/2670/
How adverse childhood experiences alter problematic cannabis use & the role of impulsivity & emotional dysregulation
Adverse Childhood Experiences and Problematic Cannabis Use: The Role of Emotion Dysregulation and Affective Impulsivity
https://pubmed.ncbi.nlm.nih.gov/38883277/
In youths, the concurrent use of tobacco & cannabis was linked to double the likelihood of externalizing problems
Concurrent Use of Tobacco and Cannabis and Internalizing and Externalizing Problems in US Youths
https://jamanetwork.com/journals/jamanetworkopen/article-abstract/2820706
For preventing adolescent cannabis use, an analysis of digital parenting interventions
Adolescent-onset cannabis use and parenting young children: an investigation of differential effectiveness of a digital parenting intervention
https://pubmed.ncbi.nlm.nih.gov/38938592/
In Canadian adolescents, why they use cannabis & what they know about the laws
Cannabis Use and Awareness of Risks and Policies Among Canadian University Students Post-Legalization
https://www.tandfonline.com/doi/full/10.1080/28367138.2024.2372720
What do Andalusian teens think about cannabis use?
Beliefs About Cannabis Use Among Male and Female Andalusian Adolescents
https://pubmed.ncbi.nlm.nih.gov/38887722/
Probably not as much as they think about an Andalusian Dog...
In adolescent mice, a thesis project on how early THC exposure led to gendered outcomes on dopamine development & adult cognition
The Tea on THC: how exposure in early adolescent male and female mice leads to divergent outcomes on dopamine development and adult cognition
https://escholarship.mcgill.ca/concern/theses/zg64ts353
In an adolescent mouse model of PCP causing adult social deficits, activating the CB1 receptor restored adult sociability deficits
Adolescent cannabinoid exposure rescues phencyclidine-induced social deficits through modulation of CA2 transmission
https://www.sciencedirect.com/science/article/abs/pii/S0301008224000881
The Brain & Neurological Disorders
In neurodegenerative diseases, a review of the role of oxidative stress, autophagy (cellular recycling) & the endocannabinoid system
Interplay among Oxidative Stress, Autophagy, and the Endocannabinoid System in Neurodegenerative Diseases: Role of the Nrf2- p62/SQSTM1 Pathway and Nutraceutical Activation
https://www.mdpi.com/1467-3045/46/7/410
And a review of CBD for neurodegenerative diseases
Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits
https://www.sciencedirect.com/science/article/abs/pii/S1568163724002046
In a neuron model of neuropathic pain from chemotherapy, various cannabinoids & cannabis extracts caused neuroprotection & the preservation of neurites (projections from the neuron that develop into axons & dendrites)
The potential neuroprotective effects of cannabinoids against paclitaxel-induced peripheral neuropathy: in vitro study on neurite outgrowth
https://pubmed.ncbi.nlm.nih.gov/38933665/
In a mouse model of HIV-1-associated neurocognitive disorder (HAND), a drug that caused positive allosteric modulation of the CB1 receptor (causing other cannabinoids to bind there more strongly, also a property of CBD) caused improvements in pain, motor coordination & recognition memory in female mice only
Cannabinoid receptor 1 positive allosteric modulator ZCZ011 shows differential effects on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice
https://pubmed.ncbi.nlm.nih.gov/38913661/
In a mouse model of cerebral ischemia-reperfusion injury (damage from blood returning to the brain), a drug that activates the CB2 receptor inhibited the release of pro-inflammatory cytokines & reactive oxygen species resulting in lessened neural impairment, brain swelling & neuronal cell death
The effects and mechanisms of AM1241 in alleviating cerebral ischemia-reperfusion injury
https://www.sciencedirect.com/science/article/pii/S0361923024001588
In a rat model of epilepsy, activating both the CB1 & 5‑HT1A serotonin receptors reduced epileptic activity
Primary somatosensory cortex CB1 and 5‑HT1A receptors interaction in the penicillin model of epilepsy
https://pubmed.ncbi.nlm.nih.gov/39087841/
And in neurons, how activating the CB1 receptor inhibited against the hyperexcitation of epileptic activity
The Role of Ion Channels and Intracellular Signaling Cascades in the Inhibitory Action of WIN 55,212-2 upon Hyperexcitation
https://www.mdpi.com/2076-3425/14/7/668
In neurons, SGIP1 ( a protein associated with energy metabolism & neuronal control) works via the regulation of CB1 receptors levels on the axon to modulate synaptic responsiveness
SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression
https://pubmed.ncbi.nlm.nih.gov/38864427/
For Parkinson's disease, a thesis project on using roundworms as a model to determine the effectiveness of CBD as a treatment
Cannabinoids and Neurodegeneration: Using C. elegans as a Model System to Determine the Effectiveness of CBD as a Treatment for Parkinson’s Disease
https://digital.wpi.edu/concern/student_works/z603r2859?locale=fr
Mental Health & Substance Use Disorders
A review of CBD for PTSD & depression
Cannabidiol, a promising therapy for post-traumatic stress disorder and depression. A mini-review
https://intapi.sciendo.com/pdf/10.2478/amma-2024-0012
And for treating anxiety, a review of drugs targeting the endocannabinoid enzymes FAAH & MAGL (which break down anandamide & 2-AG respectively)
Endocannabinoid Hydrolase Inhibitors: Potential Novel Anxiolytic Drugs
https://pubmed.ncbi.nlm.nih.gov/38882045/
In people with trauma, one week of CBD did not effectively reduce trauma-relevant emotional arousal
The effects of acute versus repeated cannabidiol administration on trauma-relevant emotional reactivity: A double-blind, randomized, placebo-controlled trial
https://onlinelibrary.wiley.com/doi/abs/10.1002/jts.23072
In Québec, both the legalization of cannabis & the COVID pandemic increase the diagnosis rates of cannabis-related disorders
Changes in the incidence of cannabis-related disorders after the Cannabis Act and the COVID-19 pandemic in Québec, Canada
https://pubmed.ncbi.nlm.nih.gov/38870546/
The validation of a Spanish empathy test showed cannabis users to be deficient in emotional recognition & to have a dampened reaction to negative stimuli
Validation of the Spanish version of the multifaceted empathy test: comparison between cannabis use effects and controls in social cognition
https://pubmed.ncbi.nlm.nih.gov/38935429/
In victims of sexual assault or other traumatic experiences, the effects on their cannabis use & how this is altered by gender
Effects of sexual assault vs. other traumatic experiences on emotional and cannabis use outcomes in regular cannabis users with trauma histories: moderation by gender?
https://pubmed.ncbi.nlm.nih.gov/38882518/
A genetic analysis of the interplay between schizophrenia, cannabis use disorder & tobacco use
Cracking the chicken and egg problem of schizophrenia and substance use: Genetic interplay between schizophrenia, cannabis use disorder, and tobacco smoking
https://pubmed.ncbi.nlm.nih.gov/38862577/
In sexual minority people, the trends of their cannabis use in relation to stress
Cannabis use trajectories over time in relation to minority stress and gender among sexual and gender minority people
https://pubmed.ncbi.nlm.nih.gov/38878644/
In a rat model of cannabis vapor self-administration, a thesis project analyzing the behavioral & biological predictors of more frequent use
IDENTIFYING BEHAVIORAL AND BIOLOGICAL PREDICTORS OF CANNABIS VAPOR SELF-ADMINISTRATION IN FEMALE AND MALE RATS
https://rex.libraries.wsu.edu/esploro/outputs/graduate/IDENTIFYING-BEHAVIORAL-AND-BIOLOGICAL-PREDICTORS-OF/99901125140301842
“The Positive Valence model was significant, accounting for 21.1% of the variance in cannabis self-administration, with greater motivation for sucrose reinforcement predicting higher rates of cannabis self-administration (p=.008). The Cognition model was significant, accounting for 17.9% of the variance in cannabis self-administration. Specifically, better visual cue discrimination and poorer set shifting performance each predicted higher rates of cannabis self-administration (p’s = .015 and .030, respectively). The Arousal/Regulatory Systems model was also significant, accounting for 59.3% of the variance in cannabis self-administration. Specifically, higher concentrations of basal corticosterone (CORT) predicted higher rates of cannabis vapor self-administration (p = .005), while lower concentrations of plasma anandamide (AEA) content predicted higher rates of self-administration (p = .008).”
In a rat model of improving memory, learning a new task increased their levels of BDNF (a brain growth factor) but it did not alter their drug-seeking or drug-taking behavior of cocaine or cannabinoids
Working memory performance predicts, but does not reduce, cocaine- and cannabinoid-seeking in adult male rats
https://pubmed.ncbi.nlm.nih.gov/38853853/
Pain & Inflammation
A review of using synthetic cannabinoids for treating pain
The State of Synthetic Cannabinoid Medications for the Treatment of Pain
https://link.springer.com/article/10.1007/s40263-024-01098-9
And a review on using cannabis derivatives for chronic pain
The diverse use of cannabis derivatives in the treatment of chronic pain
https://headachemedicine.com.br/index.php/hm/article/view/1054
A review of how anandamide modulates pain transmission through the spinal cord
Anandamide-Mediated Modulation of Nociceptive Transmission at the Spinal Cord Level
https://pubmed.ncbi.nlm.nih.gov/38957948/
In a rat model of pain from incisions, there is an additive painkilling power from combining morphine with an anandamide reuptake inhibitor
Additive antinociceptive action of intrathecal anandamide reuptake inhibitor and morphine in the management of post-incisional pain in rats
https://www.sciencedirect.com/science/article/pii/S0753332224009387
In a mouse model of neuropathic pain from chemotherapy, chronic administration of drugs that activated the CB1 and/or CB2 receptor reduced pain but the CB1 drugs tend to cause tolerance development faster in females as well as differing hormonal changes from both types of drugs
Chronic administration of cannabinoid agonists ACEA (CB1), AM1241 (CB2), and CP55,940 (mixed CB1/CB2) induce sex-specific differences in tolerance and sex hormone changes in a chemotherapy-induced peripheral neuropathy
https://pubmed.ncbi.nlm.nih.gov/38936979/
On improving the anti-inflammatory effects of cannabis seeds by fermenting them in the probiotic Lactiplantibacillus plantarum
Uncovering the antiinflammatory potential of Lactiplantibacillus Plantarum fermented Cannabis Sativa L seeds
https://www.nature.com/articles/s41538-024-00285-8
And an identification of their anti-inflammatory peptides
Identification and Molecular Docking Mechanism of Novel Anti-Inflammatory Peptides from Lactobacillus paraplantarum Fermented Cannabis sativa L. (hemp) Seeds
https://www.sciopen.com/article/10.26599/FSHW.2024.9250161
Guts & Metabolism
In a tissue model of type 2 diabetes, activating the CB2 receptor protected against insulin resistance onset, lowered glucose tolerance & reversed established insulin resistance via the AKT, ERK1/2 & CREB pathways
CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00763-0
For diabetes, screening hemp seed proteins for their ability to modulate a class of antihyperglycemic drugs (dipeptidyl peptidase-IV (DPPIV) inhibitory peptides)
Computational Screening for the Dipeptidyl Peptidase-IV Inhibitory Peptides from Putative Hemp Seed Hydrolyzed Peptidome as a Potential Antidiabetic Agent
https://pubmed.ncbi.nlm.nih.gov/38891918/
Developing nanoparticles of cannabis extracts for gastrointestinal release
Development, Characterization and In Vitro Gastrointestinal Release of PLGA Nanoparticles Loaded with Full‑Spectrum Cannabis Extracts
https://addi.ehu.es/bitstream/handle/10810/68712/s12249-024-02836-4.pdf?sequence=1&isAllowed=y
Reproduction & Hormones
In pregnant people, a survey found that they generally see mandatory warning signs about cannabis use during pregnancy to be stigmatizing & not justified by the scientific evidence
Mandatory Warning Signs for Cannabis: Perspectives and Preferences of Pregnant and Recently Pregnant People Who Use Cannabis
https://pubmed.ncbi.nlm.nih.gov/38900050/
In a rat model of prenatal exposure to THC & CBD, there were sex-specific changes to the prefrontal cortex & hippocampus
Prenatal tetrahydrocannabinol and cannabidiol exposure produce sex-specific pathophysiological phenotypes in the adolescent prefrontal cortex and hippocampus
https://www.sciencedirect.com/science/article/pii/S0969996124001888
A thesis project on prenatal THC exposure shows a reduction in brain volume with greater effects in females
Impact of prenatal exposure to delta-9-tetrahydrocannabinol on trajectories of brain development in mice
https://escholarship.mcgill.ca/concern/theses/cj82kd816
“The main effect of THC exposure indicates reduced brain volumes with greater effects in females than males. Additionally, there was evidence of anxiety-like behavior in females, and trend-level impairment to sensorimotor gating.”
The Heart
In daily & occasional cannabis users, smoking cannabis transiently increased heart rate
Dose of Product or Product Concentration: A Comparison of Change in Heart Rate by THC Concentration for Participants Using Cannabis Daily and Occasionally
https://www.liebertpub.com/doi/abs/10.1089/can.2024.0030
In a model of atherosclerosis (hardened arteries), CBD reduced foam cell formation, & the removal of cholesterol via PPARγ, ABCA1/ABCG1 & ceramide
Cannabidiol (CBD) Inhibits Foam Cell Formation via Regulating Cholesterol Homeostasis and Lipid Metabolism
https://pubmed.ncbi.nlm.nih.gov/38932553/
And in atherosclerosis, a thesis project on the role of the body’s CB1 receptors
Role of peripheral CB1 cannabinoid receptors in atherosclerosis and metabolism
https://edoc.ub.uni-muenchen.de/33659/1/Chen_Bingni.pdf
For protection of the heart, an analysis by the EU of drugs that activate the CB2 receptors found that while they did have cardioprotective effects, they did not meet all three of their strict steps of their IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria
Re-evaluation of the cardioprotective effects of cannabinoids against ischemia-reperfusion injury according to the IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria
https://pubmed.ncbi.nlm.nih.gov/38873412/
The Genitourinary System
In a mouse model of interstitial cystitis (a chronic bladder condition of pain & inflammation), the terpene beta-caryophyllene lessened inflammation & pain-related behavioral changes as well as improvements to bladder microvasculature
Phytosomal Beta-Caryophyllene for the Treatment of Pain and Inflammation in Interstitial Cystitis
https://dalspace.library.dal.ca/handle/10222/84309
The Skin
In rats with burned skin, cannabis seed oil improved wound contraction & healing rates
In vivo and in silico studies of the effects of oil extracted from Cannabis sativa L. seeds on healing of burned skin wounds in rats
https://pubmed.ncbi.nlm.nih.gov/38919274/
In dogs with atopic dermatitis (itchy rashes), oral CBD lowered the oxidative stress markers in their blood though did not result in clinically significant results
A Pilot Evaluation of Oxidative Stress Markers and Peripheral Blood Mononuclear Cell Cytokine mRNA of Atopic Dermatitis Dogs Treated with Full Spectrum Cannabis Oil
https://www.preprints.org/manuscript/202406.2010/v1
A hydrogel for skin regeneration with CBD & the terpene α-terpineol
New Polymeric Hydrogels with Cannabidiol and α-Terpineol as Potential Materials for Skin Regeneration-Synthesis and Physicochemical and Biological Characterization
https://pubmed.ncbi.nlm.nih.gov/38892121/
Creating nanoliposomes of PEA for transdermal delivery as an anti-inflammation tool
Palmitoylethanolamide-Incorporated Elastic Nano-Liposomes for Enhanced Transdermal Delivery and Anti-Inflammation
https://www.mdpi.com/1999-4923/16/7/876
Cancer & Chemotherapy
In cancer patients, the Malaysian formula Paisali (containing cannabis) reduced their chemotherapy-induced vomiting amber saying the toxicity to their body
Blood Poisoning of Cancer Patients Resulting from the Use of Paisali Containing Mixed Cannabis
https://openurl.ebsco.com/EPDB%3Agcd%3A2%3A25987986/detailv2?sid=ebsco%3Aplink%3Ascholar&id=ebsco%3Agcd%3A178054322&crl=c
For killing breast cancer cells, extracts of camel milk enhanced CBD’s bioavailability (and thus destructive power)
Enhanced oral bioavailability and in vitro evaluation of cannabidiol camel milk-derived exosome formulation in resistant MDA-MB-231 and MDA-MB-468 breast cancer cells
https://pubmed.ncbi.nlm.nih.gov/38914353/
In a rat model of leukemia, CBD successfully restored normal levels of white blood cells, red blood cells, hemoglobin, platelets & other biomarkers
Cannabidiol oil's effects on blood measurements in rats with experimentally generated Leukemia
https://bfszu.journals.ekb.eg/article_363504_4ca2a7c1bd0c210998ed9c5746943c61.pdf
And for leukemia, on the potential of treatment by Lebanese cannabis oil
Lebanese cannabis oil as a potential treatment for acute myeloid leukemia: In vitro and in vivo evaluations
https://www.sciencedirect.com/science/article/abs/pii/S0378874124008110
In gliomas (the most aggressive brain cancer), FAAH enzymes reduced their viability, proliferation & migratory potential without toxicity to normal cells
Fatty Acid Amides Suppress Proliferation via Cannabinoid Receptors and Promote the Apoptosis of C6 Glioma Cells in Association with Akt Signaling Pathway Inhibition
https://www.mdpi.com/1424-8247/17/7/873
In colorectal cancer, a computer analysis suggested that CBD would reduce their activity via inhibition of the MAPK pathway
Cannabidiol Acts as a Predicted Inhibitor of the MAPK Pathway in Colorectal Cancer
https://www.researchgate.net/publication/381942838_Cannabidiol_Acts_as_a_Predicted_Inhibitor_of_the_MAPK_Pathway_in_Colorectal_Cancer
In neuronal & non-neuronal cells, a thesis project on PEA protecting them against the toxicity of the cancer treatment paclitaxel
Effects of palmitoylethanolamide against the toxicity of paclitaxel on primary dorsal root ganglion neuronal and non-neuronal cells
https://opendata.uni-halle.de/handle/1981185920/118438
Synthetic Cannabinoids
Creating proteins that act like synthetic cannabinoids (which are lipids/fats)
Synthesis and functional evaluation of proteinogenic amino acid-derived synthetic cannabinoid receptor agonists related to MPP-5F-PICA, MMB-5F-PICA, and MDMB-5F-PICA
https://pubmed.ncbi.nlm.nih.gov/38911147/
A method for detecting synthetic cannabinoids in cannabis plant materials
Activity-based detection of synthetic cannabinoid receptor agonists in plant materials
https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-024-01044-4
A new tool for identifying THCP in cannabinoid products
Δ9-Tetrahydrocannabiphorol: Identification and quantification in recreational products
https://www.sciencedirect.com/science/article/abs/pii/S246817092400047X
Characterizing the side products & intermediates produced during the synthesis of HHC
Isolation and characterization of synthesis intermediates and side products in hexahydrocannabiphorol
https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdf/10.1002/dta.3759
Metabolites & metabolic pathway of 5F-EDMB-PICA
Identification of phase-I and phase-II metabolites and the metabolic pathway of the novel synthetic cannabinoid 5F-EDMB-PICA in vitro
https://link.springer.com/article/10.1007/s00204-024-03790-7
For postmortem analyses, the distribution of a synthetic cannabinoid in pigs is not greatly altered after death
Does a postmortem redistribution affect the concentrations of the 7 azaindole-derived synthetic cannabinoid 5F-MDMB-P7AICA in tissues and body fluids following pulmonary administration to pigs?
https://link.springer.com/article/10.1007/s00204-024-03815-1
Cool Chemistry & Tools
Screening for cannabinoid activity using a CB1 yeast biosensor
A Humanized CB1R Yeast Biosensor Enables Facile Screening of Cannabinoid Compounds
https://pubmed.ncbi.nlm.nih.gov/38892247/
A hot-melt CBD oral delivery system
Formulation Development and Evaluation of Cannabidiol Hot-Melt Extruded Solid Self-Emulsifying Drug Delivery System for Oral Applications
https://pubmed.ncbi.nlm.nih.gov/38862810/
A new CB2 agonist that is limited to the body for treating inflammation & tissue injury
A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor-selective full agonist for in vivo studies
https://pubmed.ncbi.nlm.nih.gov/38903103/
And a new fluorescent CB2 drug to detect activation of the microglia (guardian immune cells of the brain)
N-Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R)
https://pubmed.ncbi.nlm.nih.gov/38937147/
Thanks.
- lex
PS: In one of the coolest albums I know, Mickey Hart (the drummer of the Grateful Dead) collected drum music from around the world into the legendary album ‘Planet Drum’. Not only a famous drummer himself, Hart became a musicologist who found & popularized forms of percussion from around the world. His book about this journey is a fascinating read, especially to someone who also created a timeline of world history related to their subject of study. The Planet Drum album, book & foundation are a phenomenal contribution to world music.
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