C&P#112: sex & cannabis + menopause, endometriosis, fibromyalgia, gliomas & Tourettes
C&P#112: sex & cannabis + menopause, endometriosis, fibromyalgia, gliomas & Tourettes
Ukraine goes legal
This week…
Sex & cannabis: a chart of the complications
Cannabis for menopause symptoms & endometriosis
CBD for gliomas & cannabinoids for triple-negative breast cancer
Cannabis for Tourettes, fibromyalgia & mouth disease
Opioid users say CBD helps with withdrawal & addiction control
Stoner parents spend more time parenting
A road map for diagnosing cannabis allergies
Double dose of Richard Fariña
Hello everyone,
Welcome to the 112th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science + assorted canna-news & psychedelic updates. On the cannabinoids, ask me anything.
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Best Of Cannabinoid Science...
Clinical
For women in menopause, in a series of interviews they described cannabis as helpful for managing symptoms
Women's perceptions and experiences with cannabis use in menopause: a qualitative study
https://journals.lww.com/menopausejournal/abstract/2024/09000/women_s_perceptions_and_experiences_with_cannabis.8.aspx
In a survey of women with endometriosis, cannabis was widely used for their chronic pain
Self-Reported Use and Effectiveness of Marijuana for Pelvic Pain among Women with Endometriosis
https://assets-eu.researchsquare.com/files/rs-4536326/v1/293705e8-3d14-4038-b96e-4a0bb03739c9.pdf?c=1721151662
For arthritis, an analysis from the UK Medical Cannabis Registry showed the initiation of medical cannabis to improve pain & health-related quality of life
Assessment of clinical outcomes in patients with inflammatory arthritis: analysis from the UK Medical Cannabis Registry
https://journals.lww.com/intclinpsychopharm/fulltext/9900/assessment_of_clinical_outcomes_in_patients_with.145.aspx
For veterans at a VA Pain Clinic, those using CBD saw a significant reduction in pain
Cannabidiol (CBD) and hemp oil use in veterans using a VA Pain Clinic: a cross-sectional survey study
https://www.tandfonline.com/doi/full/10.1080/10550887.2024.2355365
A survey of people with opioid use disorder found strong interest in using CBD
Use and perceptions of Cannabidiol among individuals in treatment for opioid use disorder
https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-024-01051-5
“Some patients are already using CBD for anxiety, pain, sleep, depression, or as a harm reduction intervention to control their addiction or for opioid withdrawal symptoms.”
For parenting, state medical cannabis laws led to increased parenting time
Medical marijuana legalization and parenting behaviors: An analysis of the time use of parents
https://onlinelibrary.wiley.com/doi/abs/10.1002/jae.3084
Amen! I remember Rick Doblin once told me that before bedtime, when his kids smelled weed, they knew that it was time for a long ‘Lord of the Rings’ read aloud session.
In surgery, public health data showed cannabis users received significantly higher inhalational anesthetic doses
Cannabis Use and Inhalational Anesthesia Administration in Older Adults: A Propensity Matched Retrospective Cohort Study
https://pubs.asahq.org/anesthesiology/article-abstract/doi/10.1097/ALN.0000000000005146/141676/Cannabis-Use-and-Inhalational-Anesthesia?redirectedFrom=fulltext
For sexual experiences, interviews of people in Spain found that while alcohol facilitated sexual encounters, cannabis left people feeling more sexually satisfied
Sexual experience under the influence of alcohol and cannabis consumption
https://files.intandro.com/files/article/20240712-11/pdf/ANDROL-D-23-00042.pdf
In people living with HIV, how it alters the endocannabinoids in their blood plasma
Plasma endocannabinoidome and fecal microbiota interplay in people with HIV and subclinical coronary artery disease: Results from the Canadian HIV and Aging Cohort Study
https://www.cell.com/iscience/pdf/S2589-0042(24)01681-X.pdf
In dogs undergoing hysterectomies, CBD worked as well as meloxicam (an NSAID commonly used for arthritis) for managing acute pain
Assessment of the nociceptive response to the use of cannabidiol alone and in combination with meloxicam through infrared pupillometry in female dogs undergoing elective ovariohysterectomy
https://pubmed.ncbi.nlm.nih.gov/39027908/
In dogs with flea allergy dermatitis, nutraceuticals containing both CBD & PEA worked to lower itching, skin lesions & discomfort
The Beneficial Effect of Two Nutraceuticals in Flea Allergy Dermatitis Itch Control: A Comparative Study
https://www.researchgate.net/publication/381018612_The_Beneficial_Effect_of_Two_Nutraceuticals_in_Flea_Allergy_Dermatitis_Itch_Control_A_Comparative_Study
“Product A was a capsule containing 250 mg of blackcurrant oil in 20% of gamma-linolenic acid (GLA), 50 mg of hemp oil in 10% of cannabidiol (CDB) and 5000 IU of Vitamin D3. Product B was a capsule containing 7,53% of palmitoylethanolamide (PEA), and 754 mg/kg of Biotin.”
Harms
Making a ton of headlines, this quite small review found a link between cannabis use & head/neck cancers
A Review of Marijuana Use and Risk of Head and Neck Cancer
https://www.sciencedirect.com/science/article/abs/pii/S2212440324002670
A road map for diagnosing cannabis allergies
IgE-Mediated Cannabis Allergy and Cross-Reactivity Syndromes: A Roadmap for Correct Diagnosis and Management
https://link.springer.com/article/10.1007/s11882-024-01159-5
From public health data, current cannabis users had significantly higher hemoglobin concentrations (suggesting subclinical hypoxemia (low blood oxygen levels))
Marijuana Use and Hemoglobin Concentrations in NHANES 2009-2018: Implications for Subclinical Hypoxemia
https://www.atsjournals.org/doi/abs/10.1513/AnnalsATS.202404-357OC
For cannabinoid hyperemesis syndrome, a review on approaches to treatment
Approach to Cyclic Vomiting Syndrome and Cannabinoid Hyperemesis Syndrome
https://link.springer.com/article/10.1007/s11938-024-00457-1
And a case report of cannabinoid hyperemesis syndrome
From Chronic Cannabis to Cyclic Chaos: A Glimpse Into Cannabinoid Hyperemesis Syndrome
https://assets.cureus.com/uploads/case_report/pdf/275080/20240817-1006647-6om5t2.pdf
On liver cell toxicity by the major cannabinoids
Comparison on the mechanism and potency of hepatotoxicity among hemp extract and its four major constituent cannabinoids
https://www.sciencedirect.com/science/article/pii/S0300483X24001665
And in liver cells, CBD caused cytotoxicity
Investigation of cannabidiol-induced cytotoxicity in human hepatic cells
https://www.sciencedirect.com/science/article/abs/pii/S0300483X24001653
A case report of cannabis smoking leading to atrial fibrillation (an irregular rapid heartbeat)
Atrial Fibrillation Occurring After Smoking Marijuana: A Case Report and Review of the Literature
https://escholarship.org/uc/item/1fw0h4np
In a case series of adolescents with potential cannabinoid hyperemesis syndrome, some of them are also experiencing superior mesenteric artery syndrome (a compression of part of the intestines)
Cannabinoid hyperemesis syndrome co-occurring with superior mesenteric artery syndrome in adolescents
https://onlinelibrary.wiley.com/doi/abs/10.1002/jpn3.12317
Synthetic cannabinoids cause respiratory depressant effects & when co-administered with fentanyl in mice, reduced the respiratory rescue effects of naloxone
Respiratory Depressant Effects of Fentanyl in Combination With Synthetic Cannabinoid Receptor Agonists: A Potential Mechanism for “Narcan-Resistant” Overdose
https://www.sciencedirect.com/science/article/abs/pii/S0376871623001965
In people using nicotine or THC e-cigarettes, this thesis project showed they had elevated sputum production as well as higher levels of inflammatory immune cells & neutrophilia (primary white blood cells)
Effects of Vaping Nicotine and Tetrahydrocannabinol (THC) E-cigarettes on Inflammatory Biomarkers, Gene Expression, and Airway Resistance
https://escholarship.org/uc/item/3tp2x19h
A book chapter on treating cannabis use disorder
Cannabis Use Disorder and Treatment
https://www.taylorfrancis.com/chapters/edit/10.1201/9781003227793-117/cannabis-use-disorder-treatment-julia-bujno-deborah-hasin
Reviews
On cannabis & human sexuality (one great chart!)
Update on cannabis in human sexuality
https://link.springer.com/article/10.1007/s00213-024-06643-4
For anxiety, review of the mechanisms of cannabinoids
The anxiolytic effects of cannabinoids: A comprehensive review
https://www.sciencedirect.com/science/article/abs/pii/S0091305724001229
On the lung impacts of cannabis, a review by the great Tashkin himself
Impact of Marijuana Use on Lung Health
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0044-1785679
For gliomas (the most aggressive brain cancer), a review of using CBD
From bench to bedside: the application of cannabidiol in glioma
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05477-0
And for triple-negative breast cancer, a review of treatment with cannabinoids
Cannabinoids and triple-negative breast cancer treatment
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1386548/full
And a review on why cancer survivors should both exercise & activate their endocannabinoid system
Investigating endocannabinoid system and subjective responses to exercise in cancer patients: Rationale and future research directions
https://www.sciencedirect.com/science/article/pii/S277269672400022X
For Tourette syndrome, this review of 12 studies found cannabis to lessen tic severity & urges
Efficacy of cannabis-based medicine in the treatment of Tourette syndrome: a systematic review and meta-analysis
https://link.springer.com/article/10.1007/s00228-024-03710-9
Because it's being sold in gas stations, a short review of THCV
Tetrahydrocannabivarin is Not Tetrahydrocannabinol
https://www.liebertpub.com/doi/pdf/10.1089/can.2024.0051
For fibromyalgia, a review of using cannabis
Medical cannabis and fibromyalgia: a narrative review of current evidence
https://www.magonlinelibrary.com/doi/abs/10.12968/bjnn.2024.0028
For periodontal disease, a review of therapeutic cannabinoids & the known alterations of the endocannabinoid system (great charts!)
The Role of Different Types of Cannabinoids in Periodontal Disease: An Integrative Review
https://www.mdpi.com/1999-4923/16/7/893
For vascular diseases, a review on the use of cannabinoids (great chart on the effects)
Dissecting the role of cannabinoids in vascular health and disease
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcp.31373
For ocular diseases, a book chapter on using cannabinoids
Therapeutic Potential of Cannabinoids in Ocular Diseases
https://www.researchgate.net/publication/381861065_Therapeutic_Potential_of_Cannabinoids_in_Ocular_Diseases
On food addiction, a book chapter about the endocannabinoid signaling
Endocannabinoid Signaling and Food Addiction
https://books.google.fr/books?hl=en&lr=lang_en&id=RwcSEQAAQBAJ&oi=fnd&pg=PA146&dq=cannabinoid&ots=QPNG1Roh-d&sig=uDU6TOO5kcOPkXxO83Wm7TZxo78&redir_esc=y#v=onepage&q=cannabinoid&f=false
Preclinical
In a mouse model of hypoxia (loss of oxygen to the brain), CBD prevented the loss of antioxidant machinery, reduced lipid breakdown & lowered detrimental consequences
Cannabidiol effectively prevents oxidative stress and stabilizes hypoxia-inducible factor-1 alpha (HIF-1α) in an animal model of global hypoxia
https://www.nature.com/articles/s41598-024-66599-5
In a genetic analysis & mouse model of oral mucositis (tissue swelling & irritation in the mouth, often caused by cancer treatment), CBD reduced lesions & downregulated almost 50 related genes
Cannabidiol Alleviates Oral Mucositis by Inhibiting PI3K/Akt/NF-κB-Mediated Pyroptosis
https://pubmed.ncbi.nlm.nih.gov/38966918/
In a mouse model of cardiovascular toxicity, CBD protected the heart & aorta against systemic inflammation & oxidation
Cannabidiol ameliorates lipopolysaccharide-induced cardiovascular toxicity by its antioxidant and anti-inflammatory activity via regulating IL-6, Hif1α, STAT3, eNOS pathway
https://link.springer.com/article/10.1007/s11033-024-09772-3
In female rats, this thesis project found that THC lowered inflammation & enhanced neurogenesis in the hippocampus (memory center of the brain)
Administration of delta-9-tetrahydrocannabinol impacts hippocampal formation neurogenesis in female Wistar rats
https://repositorio-aberto.up.pt/handle/10216/159598
In a mouse model of neuropathic pain from chemotherapy, the synthetic cannabinoid JWH-182 was safe & effective
JWH-182: a safe and effective synthetic cannabinoid for chemotherapy-induced neuropathic pain in preclinical models
https://www.nature.com/articles/s41598-024-67154-y
For protecting the skin from UV-A, a nano-CBD topical reduced mutations associated with skin aging
Topical nanoencapsulated cannabidiol cream as an innovative strategy combating UV-A–induced nuclear and mitochondrial DNA injury: A pilot randomized clinical study
https://www.jaad.org/article/S0190-9622(24)02490-3/fulltext
On how CBE (a breakdown product of CBD) activates the CB1 receptor
Cannabielsoin (CBE), a CBD Oxidation Product, Is a Biased CB1 Agonist
https://www.mdpi.com/2227-9059/12/7/1551
A new cannabinoid compound: canniprene B
Canniprene B, a new prenylated dihydrostilbene with cytotoxic activities from the leaves of Cannabis sativa
https://www.tandfonline.com/doi/full/10.1080/14786419.2024.2376348
the Headlines & Fav Articles
Great: a federal judge ruled that Tennessee officials can be held liable for taking five kids out of the custody of their mother for a small amount of cannabis
https://www.marijuanamoment.net/after-taking-custody-of-five-kids-over-marijuana-tennessee-officials-can-be-held-liable-for-their-actions-federal-judge-rules
While driving to a funeral, they pull over this lady’s car because she’s driving too slow. When they find a small amount of cannabis (>5g), they took away her 5 children & placed them in foster homes for the next two months. The oldest was 7 & the youngest was just 4 months old.
In Missouri, massive product recalls
https://www.marijuanamoment.net/missouri-cannabis-companies-scramble-to-respond-to-massive-product-recalls
A survey of 500+ vape shops found that the majority sold intoxicating cannabinoid products
Intoxicating Cannabis Products in Vape Shops: United States, 2023
https://www.sciencedirect.com/science/article/abs/pii/S0749379724002290
And similar findings from a pilot study in Cleveland
Availability and Characteristics of Hemp-Derived Psychoactive Cannabis Products: A Pilot Study in Cleveland, Ohio
https://ojph.org/index.php/OJPH/article/view/9747
A book review about crimes against Native people during California's Gold Rush & Green Rush
Settler Cannabis: From Gold Rush to Green Rush in Indigenous Northern California
https://scholarworks.lib.csusb.edu/cgi/viewcontent.cgi?article=1315&context=history-in-the-making
Profile of the cannabis cartoonist, Brian “Box” Brown
https://stupiddope.com/2024/08/brian-box-brown-cannabis-legalization-cartoonist/
Slang Corner: somehow, in a prestigious medical journal, a great compilation of slang words for drugs
When I use a word . . . The languages of medicines—what street drugs are called
https://www.bmj.com/content/386/bmj.q1495.full
History Corner: the story of cannabis in the ‘Emerald Triangle’ of Northern California
Introduction To The Northern California Situation: From Counterculture To Legalization- Cannabis In The “Emerald Triangle”
https://shs.hal.science/halshs-04631062/document#page=21
History Corner2: in the NYTimes, all the times they mention cannabis from 1851 to 1939
Historical Framing in The New York Times
https://swecjmc-ojs-txstate.tdl.org/swecjmc/article/view/140
And an analysis of early 20th century newspaper articles found cannabis to be both a vilification of Mexican people as well as a heterogeneous “othering” of numerous other minority groups
The Framing of Minority Threat and Moralization to Criminalize Behavior: The Case of Cannabis in the Early 20th Century
https://academic.oup.com/socpro/advance-article-abstract/doi/10.1093/socpro/spae032/7710025?redirectedFrom=fulltext
International
Ukraine legalizes medical cannabis
https://www.marijuanamoment.net/ukraine-medical-marijuana-legalization-law-officially-takes-effect-amid-ongoing-russian-conflict/
#fuckputin
In Morocco, the king pardons nearly 5000 people of illegal cannabis cultivation charges
https://www.reuters.com/world/africa/morocco-pardons-nearly-5000-cannabis-farming-convicts-2024-08-20
Pakistan legalizes hemp production for next year
https://english.aaj.tv/news/330375450/pakistan-to-allow-commercial-cultivation-of-hemp-from-january-2025
Rwanda set to finish its first big grow facility for making 25,000 kg, but journalist Lydia Kariuki asks, where will they be selling it?
https://medium.com/@lidomungure/kkog-rwandas-production-of-25-000-kg-of-medicinal-grade-cannabis-leaves-kenyans-salivating-but-f9668776f27a
In Thailand, analysis of the current situation & new trends
CURRENT SITUATION AND NEW TRENDS OF THAILAND CANNABIS INDUSTRY
http://icbtsproceeding.ssru.ac.th/index.php/ICBTSPARIS2024/article/view/1404
In Germany, a thesis project analyzing the role of Instagram in shaping cannabis policy
Instagram's Role in Shaping Germany's Cannabis Policy
https://essay.utwente.nl/101684/1/Tegge_BA_BMS.pdf
In Canada, an analysis of the corporate social responsibility disclosures of cannabis firms
What does it mean to be responsible for Canadian Cannabis firms? An examination of CSR identity through social media disclosure
https://www.emerald.com/insight/content/doi/10.1108/MEDAR-08-2023-2136/full/html
In Latin America, an analysis of how cannabis reforms is diffusing through the societies of Argentina, Chile, Paraguay & Uruguay
Change from Above or Pressure from Below? The Diffusion of Cannabis Reform in Latin America
https://onlinelibrary.wiley.com/doi/pdf/10.1111/blar.13580
Under Islamic law, analyzing the uses of cannabis
Uses and Implications of Marijuana from the Perspective of Islamic Law
https://journals.qu.edu.qa/index.php/sharia/article/view/4336
The Laws, The War on Drugs & the End of Prohibition
Introducing harm reduction 2.0: Mindful Consumption & Benefit Maximization
Harm reduction isn't enough: Introducing the concept of Mindful Consumption and Benefit Maximization (MCBM)
https://www.sciencedirect.com/science/article/abs/pii/S0955395924001993
On the thorny intersection with the rise of both medical cannabis & adult drug treatment courts
The Thorny Intersection Between Adult Drug Treatment Courts and Medical Marijuana Criminal Immunity Laws
https://onlinelibrary.wiley.com/doi/abs/10.1111/soin.12621
On the youth drug education campaign put out by Canadian Students for Sensible Drug Policy (CSSDP)
This is your brain on drug education: Putting young people with lived experience at the center of drug education
https://www.sciencedirect.com/science/article/abs/pii/S095539592400152X
For driving & blood THC levels, a meta-analysis of crash risk & THC concentrations
Dose response relationship between blood concentrations of THC and crash culpability risk: meta-regression of culpability studies
https://osf.io/preprints/psyarxiv/mp9sz
“We show that crash culpability risk increases with increasing THC concentration, with an inflection around 1.5-3.0 ng/ml where risk begins to increase. There is a doubling of risk around 5 ng/ml, and a potential quadrupling of risk around 10 ng/ml. Conversely, blood THC concentrations below ~1.5 ng/ml indicate practically no risk.”
On detecting cannabinoids in the breath
Cannabinoids detected in exhaled breath condensate after cannabis use
https://iopscience.iop.org/article/10.1088/1752-7163/ad6347/pdf
And using eye tracking to measure cannabis impairment
Cannabis Impairment Monitoring Using Objective Eye Tracking Analytics
https://arxiv.org/pdf/2407.13701
In the UK, foreign travelers brazenly bringing in ‘suitcases full of cannabis’
https://cannabislaw.report/uk-national-crime-agency-says-us-thai-canadian-travellers-brazenly-bringing-suitcases-full-of-cannabis-into-uk
States with liberalized cannabis policies only saw increased blunt sales if that state lacked strong tobacco controls
Cannabis policy liberalization is only associated with increased blunt use if states lack strong tobacco control
https://www.sciencedirect.com/science/article/pii/S0306460324001497
Sales data found that a state legalizing cannabis led to a ~5% increase in CBD food sales
Marijuana Legalization and Hemp Policies and Demand for Hemp and Cannabidiol (CBD) Foods
https://ideas.repec.org/p/ags/aaea22/343804.html
Psychedelics, Plant Medicines & Other Psychoactives
On the classic countercultural novel ‘Been Down So Long It Looks Like Up To Me’ by the multi-talented Richard Fariña (see his album at the bottom of this email)
https://doubleblindmag.com/richard-farina/
As I often have to say when I read a great book when I was young, thanks Dad.
The Psychoactive Research
Meth is a second most used illegal drug after cannabis. Here are the reasons that people do it…
Reasons for using methamphetamine: Systematic review
https://www.sciencedirect.com/science/article/abs/pii/S0883941724001419
Not included in this list is writing books about cannabis based on Moby Dick.
In Colorado partiers, a survey of how they combine cannabis & psychedelics
Simultaneous cannabis and psychedelic use among festival and concert attendees in Colorado: characterizing enhancement and adverse reactions using mixed methods
https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-024-00235-x
For ayahuasca, a review of potential therapeutic uses
Potential therapeutic use of ayahuasca: A literature review
https://www.scielo.br/j/aa/a/h8JySzrJnp5ZDLKFnKsRYBb/
How the reforms around psilocybin mushrooms have increased public interest in psilocybin with cross-effects for LSD & MDMA
Magic of the Mushrooms: Effects of Psilocybin Decriminalization
https://www.tandfonline.com/doi/full/10.1080/02791072.2024.2376755
The Plant & the History
Growing, Farming & Processing
Analysis of the effects of short-term storage on cannabinoid content
Effect of short-term storage on cannabinoid content of dried floral hemp (Cannabis sativa L) inflorescence
https://www.sciencedirect.com/science/article/abs/pii/S2214786124000408
And on differences in decarboxylation rates between cannabinoids In the secretory cavities versus air-dried inflorescences
Comparison of decarboxylation rates of acidic cannabinoids between secretory cavity contents and air-dried inflorescence extracts in Cannabis sativa cv. ‘Cherry Wine’
https://www.nature.com/articles/s41598-024-66420-3
On flushing your plants, this study found only minor effects on yield & plant development
To flush or not to flush: Does flushing the growing media affect cannabinoid and terpenoid production in cannabis?
https://www.sciencedirect.com/science/article/abs/pii/S0926669024011348
For cannabis yield, the effect of spacing, fertilizer, rhizobacteria & chemical properties of the soil
Spacing, Fertilizer and PGPR on Yield and Nutrient Uptake in Industrial Hemp (Cannabis sativa ssp. sativa) and Chemical Properties of Soil
https://www.researchgate.net/publication/381887996_Spacing_Fertilizer_and_PGPR_on_Yield_and_Nutrient_Uptake_in_Industrial_Hemp_Cannabis_sativa_ssp_sativa_and_Chemical_Properties_of_Soil
And how to optimize hemp for fiber & seed
Optimization of hemp production technology for fiber and seed
https://www.sciencedirect.com/science/article/abs/pii/S092666902401104X
The environmental impacts of producing cannabis outdoors
Environmental Impact of Outdoor Cannabis Production
https://pubmed.ncbi.nlm.nih.gov/39027629/
“Results show that outdoor cannabis agriculture can be 50 times less carbon-emitting than indoor production.”
On monitoring & control systems for cannabis
Sistema de monitoreo y control de cultivo indoor de cannabis
https://redum.um.edu.uy/handle/20.500.12806/2590
On the feral cannabis of the Midwest, an analysis of its ecological niches
Utilizing digitized occurrence records of Midwestern feral Cannabis sativa to develop ecological niche models
https://onlinelibrary.wiley.com/doi/pdf/10.1002/ece3.11325
In fields contaminated with copper, the effects on hemp & the possibility of phytoremediation
Macronutrients dynamics in copper-contaminated soils: Implications for hemp growth and its phytoremediation potential
https://www.sciencedirect.com/science/article/pii/S2666154324003363
A survey of microbial contaminants from two Italian sites
A three-years survey of microbial contaminants in industrial hemp inflorescences from two Italian cultivation sites
https://link.springer.com/article/10.1186/s42238-024-00241-z
And characterizing the parasitic worm Boleodorus volutus first found in hemp roots in Baltimore
MORPHOLOGICAL AND MOLECULAR CHARACTERIZATION OF BOLEODORUS VOLUTUS IN THE UNITED STATES FROM THE RHIZOSPHERE OF MEDICINAL HEMP
https://www.researchgate.net/publication/382170321_MORPHOLOGICAL_AND_MOLECULAR_CHARACTERIZATION_OF_BOLEODORUS_VOLUTUS_IN_THE_UNITED_STATES_FROM_THE_RHIZOSPHERE_OF_MEDICINAL_HEMP
Analysis of hash from the Himalayas
Phytocannabinoid profile and potency of cannabis resin (hashish) of northwest Himalayas of India
https://onlinelibrary.wiley.com/doi/abs/10.1111/1556-4029.15583
In cultivars of cherry wine hemp, a thesis project on the variability of cannabinoid & terpene content
Analyzing the Variability of Cannabinoid and Terpene Content in Cherry Wine Hemp Cultivars
https://www.proquest.com/openview/6f4a7ca3ee3dadbc6243ba24ec42bd5a/1?pq-origsite=gscholar&cbl=18750&diss=y
On extracting triterpenoids from cannabis roots using green techniques
Green Techniques for Extracting Triterpenoids from Cannabis Roots
https://pubs.acs.org/doi/full/10.1021/acssuschemeng.4c02920
In cannabis leaves, how genetic transcription alters their arrangements
Cannabis leaf arrangement: Transcriptome insights into Cannabis sativa phyllotactic regulation
https://link.springer.com/article/10.1007/s40502-024-00801-8
In the 1830s, how was hemp being grown in northwest England
Hemp Cultivation and Processing in North-West England
https://www.tandfonline.com/doi/full/10.1080/0078172X.2024.2374480
Food & Nutrition
On people's motivations for buying hemp foods
Hemp Food Motivations: The Role Of Food/Diet Preference And Health Conditions On Hemp Food Purchases
https://ideas.repec.org/p/ags/aaea22/343736.html
Consumers tend to support the idea of hemp-fed aquaculture
Consumer Perceptions of Hemp-Fed Aquaculture
https://www.proquest.com/openview/e287a61ed4a846c7851dcdb6e7e378f7/1?pq-origsite=gscholar&cbl=18750&diss=y
A thesis review of feeding hemp to ruminants
INDUSTRIAL HEMP (Cannabis sativa L.) FOR A SUSTAINABLE FEEDING OF RUMINANTS: NUTRITIONAL CHARACTERIZATION AND EFFECTS ON ANIMAL PERFORMANCE
https://www.research.unipd.it/bitstream/11577/3518407/2/PhD.pdf
An overview of processing hemp in the food
Production of plant protein from seeds and cake of industrial hemp: Overview of processing methods for food industry
https://www.fsjour.com/jour/article/view/480
On producing hemp seed oil with supercritical CO2 extraction
Supercritical CO2 Extraction Method for Hemp Seed Oil Production
https://rsucon.rsu.ac.th/files/proceedings/RSUSCI2024/IN24-083.pdf
On the effects of oven roasting on hemp seeds
Oven roasting effects on the physicochemical and chemosensory characteristics of hemp seeds (Cannabis sativa L.)
https://link.springer.com/article/10.1007/s13197-024-06033-w
Industrial Use
Hemp boards & making them more ecological
Enhancing eco-efficiency in hemp-based construction boards: environmental and economic strategies for sustainability
https://www.tandfonline.com/doi/full/10.1080/14486563.2024.2377779
On hempcrete in Slovenia
Hempcrete housing as a sustainable restoration solution at Novo Mesto, Slovenia: Building towards carbon neutrality performances
https://assets-eu.researchsquare.com/files/rs-4615616/v1/c6c9d821-0767-484e-aa2f-9d71a4814390.pdf?c=1721334172
A review of the versatile uses of cannabis such as the green synthesis of nanoparticles
Potentials of Cannabis as versatile additive in consumer, industrial and medicinal products and green synthesis of nanoparticles: A systematic review
https://www.cabidigitallibrary.org/doi/abs/10.1079/cabireviews.2024.0023
CANNABINOID SCIENCE
On methods for best testing practices for endocannabinoids in plasma
Endocannabinoid analysis in GlucoEXACT plasma: Method validation and sample handling recommendations
https://www.sciencedirect.com/science/article/pii/S003991402400897X
An analysis of cannabis potency testing & how the reference materials might be the largest contributor to uncertainty
Measurement uncertainty revealed: The impacts of Certified Reference Material (CRM) on cannabinoid concentrations in the cannabis testing industry
https://www.sciencedirect.com/science/article/pii/S2666831924000584
Public Health
A survey of nurses found that they usually use their cannabis after work
Uncovering Trends in U.S. Nurse Cannabis Use in Relation to Patient Care
https://www.sciencedirect.com/science/article/abs/pii/S2155825624000516
In a survey of Portuguese nurses, the majority appreciated the benefits of medical cannabis but few had heard of the endocannabinoid system
Knowledge, opinions and experiences of nurses and nursing students in Portugal regarding the use of Medical Cannabis
https://assets-eu.researchsquare.com/files/rs-4590620/v1/0bdb8621-aafe-4340-9c16-2d7010bd8aa9.pdf?c=1721233115
In Germany during the COVID pandemic, predictors of whose usage of cannabis would change
Predictors of changes in marijuana consumption in Germany during the covid-19 pandemic
https://link.springer.com/article/10.1007/s00406-024-01861-5
Most medical students in southern Israel are favorable towards medical cannabis & legalization
Attitudes and Knowledge of Medical Students in South of Israel Toward Medical Cannabis
https://journals.lww.com/americantherapeutics/abstract/2024/08000/attitudes_and_knowledge_of_medical_students_in.4.aspx
Adolescents & Young Adults
In adolescents, cannabis use was associated with increased depressive symptoms but not changes in amygdala volume
Amygdala volume and depression symptoms in young adolescents who use cannabis
https://www.sciencedirect.com/science/article/abs/pii/S0166432824003061
In youth, depressive symptoms predicted cannabis vaping
Depressive symptoms predict cannabis vaping initiation among young adults
https://www.sciencedirect.com/science/article/abs/pii/S037687162400320X
In a survey of adolescents, one-third wanted to change their cannabis use while half wanted to change their e-cigarette use
Intention to quit or reduce e-cigarettes, cannabis, and their co-use among a school-based sample of adolescents
https://www.sciencedirect.com/science/article/pii/S0306460324001503
In youth, attachment to parents is linked to less cannabis use
Attachment to parents and adolescents' marijuana use, attitudes, and perceptions: Assessing the role of county-level dispensaries
https://www.sciencedirect.com/science/article/abs/pii/S0047235224000734
For young people, nicotine vaping associated with the subsequent initiation of cannabis & other substances
Is nicotine vaping associated with subsequent initiation of cannabis or other substances from adolescence into young adulthood?
https://academic.oup.com/aje/advance-article-abstract/doi/10.1093/aje/kwae189/7710092?redirectedFrom=fulltext
The patterns of youth initiating the co-use of tobacco & cannabis
Products and patterns through which adolescents, young adults, and adults initiate co-use of tobacco and cannabis
https://www.sciencedirect.com/science/article/abs/pii/S0306460324001540
In adolescents, the association between cannabis use & persistent nicotine use
Association between cannabis use and nicotine use persistence among adolescents
https://www.sciencedirect.com/science/article/abs/pii/S0306460324001552
On cannabis use among adolescent asthmatics
Tobacco, Vaporizers, and Cannabis in Asthmatic Adolescents
https://www.researchgate.net/publication/382215255_Tobacco_Vaporizers_and_Cannabis_in_Asthmatic_Adolescents
In young adults who experienced discrimination, they had worse cannabis use outcomes
Discrimination experiences and problematic alcohol and cannabis use in young adulthood
https://pubmed.ncbi.nlm.nih.gov/38978344/
Why young adults use cannabis in Québec’s queer ampersands trans scene
Beyond struggle: A strengths-based qualitative study of cannabis use among queer and trans youth in Québec
https://www.sciencedirect.com/science/article/pii/S095539592400197X
In an adolescent rat model of vaporized nicotine & cannabis co-exposure, the females demonstrated a heightened sensitivity to reward while males displayed learning impairments
Impact of vaporized nicotine and cannabis co-exposure in adolescence on sex-specific behavioural and neural effects in adulthood
https://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=12987&context=etd
The Brain & Neurological Disorders
In Alzheimer's disease, a review of how the endocannabinoid system gets altered
Endocannabinoid system alterations in Alzheimer's disease: A mini-review
https://wjarr.com/sites/default/files/WJARR-2024-1814.pdf
And in a mouse model of Alzheimer's, a mild traumatic brain injury altered their endocannabinoid system
Early biomarkers in the presymptomatic phase of cognitive impairment: changes in the endocannabinoidome and serotonergic pathways in Alzheimer's-prone mice after mTBI
https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-024-01820-0
In chronic cannabis users, they have alterations to their brain’s gamma activity
Chronic cannabis use alters the spontaneous and oscillatory gamma dynamics serving cognitive control
https://pubmed.ncbi.nlm.nih.gov/39023178/
In a rat model of Parkinson's disease, the synthetic cannabinoid JWH133 (which activates CB2) improved their behaviors & protected dopamine-producing neurons
JWH133 attenuates behavior deficits and iron accumulation in 6-OHDA-induced Parkinson’s disease model rats
https://journals.physiology.org/doi/abs/10.1152/jn.00137.2024
In a mouse model of traumatic brain injury, inhibiting MAGL (which breaks down 2-AG) lessened pain initiation & transmission
Inhibition of 2-AG hydrolysis alleviates posttraumatic headache attributed to mild traumatic brain injury
https://link.springer.com/article/10.1186/s10194-024-01817-z
In a rat model of ketamine anesthesia, the CB1 receptors are involved in modulating the reticular neurons which regulate sleep wake cycles
Local activation of CB1 receptors by synthetic and endogenous cannabinoids dampens burst firing mode of reticular thalamic nucleus neurons in rats under ketamine anesthesia
https://link.springer.com/article/10.1007/s00221-024-06889-6
In a rat model of mercury chloride poisoning, the terpene beta-caryophyllene lowered neurotoxicity in the cerebellum & spinal cord
Promising the potential of β-caryophyllene on mercury chloride–induced alteration in cerebellum and spinal cord of young Wistar albino rats
https://link.springer.com/article/10.1007/s00210-024-03268-4
Mental Health & Substance Use Disorders
An MRI of cannabis abstinence in humans found gendered differences in effects
A preliminary investigation of sex differences in cognitive and fMRI changes following 28 days of cannabis abstinence
https://www.sciencedirect.com/science/article/pii/S2211034824003365
How cannabis can alter the symptoms of first-episode psychosis
Behind the heterogeneity in the long-term course of first-episode psychosis: Different psychotic symptom trajectories are associated with different patterns of cannabis and stimulant use
https://www.sciencedirect.com/science/article/pii/S092099642400313X
And the role of genetic variability in the endocannabinoid receptors
Clinical and cognitive outcomes in first-episode psychosis: focus on the interplay between cannabis use and genetic variability in endocannabinoid receptors
https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2024.1414098/full
In a genetic analysis of ADHD & cannabis use disorder, there were a number of shared risk genes, especially the dopamine D2 receptor
Shared genetics of ADHD, cannabis use disorder and cannabis use and prediction of cannabis use disorder in ADHD
https://www.nature.com/articles/s44220-024-00277-3
For opioid-related memories, a review on targeting the endocannabinoid system for treating addiction
A Translational Approach to Using Endocannabinoid Modulators for Targeting Opioid-Associated Memory
https://link.springer.com/article/10.1007/s40429-024-00588-6
In India, on the abuse of cannabis & the impact on mental health
Dark Side of Cannabis: Impact on Mental Health and Rising Abuse
https://www.preprints.org/manuscript/202407.1358/v1
In medical settings, a meta-analysis found that brief drug interventions can reduce cannabis use
Brief Drug Interventions Delivered in General Medical Settings: A Systematic Review and Meta-Analysis of Cannabis Use Outcomes
https://osf.io/preprints/socarxiv/mrgty
A thesis project trying to create a rat model of cannabis use disorder
Chronic THC Consumption and Relationship to Decision Making and Impulsivity: Implication for Cannabis Use Disorder in a Rat Model
https://www.proquest.com/openview/9e32532fdb0e9daf6528ba4d1635c5b9/1?pq-origsite=gscholar&cbl=18750&diss=y
In a mouse model of anxiety with nicotine as an added stressor, the behavioral effects & memory impairment involved the endocannabinoid & endovanilloid systems
Interrelated involvement of the endocannabinoid/endovanilloid (TRPV1) systems and epigenetic processes in anxiety- and working memory impairment-related behavioural effects of nicotine as a stressor
https://onlinelibrary.wiley.com/doi/pdf/10.1111/adb.13421
Remember, anandamide is both an endocannabinoid & an endovanilloid. That’s how interrelated those systems are.
Pain & Inflammation
A review of using cannabinoids as a painkiller to mitigate the opioid epidemic
Mitigating the Opioid Epidemic: The Role of Cannabinoids in Chronic Pain Management—A Systematic Review and Meta-Analysis of Clinical Evidence and Mechanisms
https://www.researchsquare.com/article/rs-4736592/v1
In a small study of humans exercising, topical CBD did not improve muscle recovery
Topical Cannabidiol Application May Not Attenuate Muscle Soreness or Improve Performance: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study
https://www.liebertpub.com/doi/abs/10.1089/can.2024.0012?journalCode=can
In a mouse model of inflammation & chronic pain, knocking out SGIP1 (a protein that inhibits CB1 receptors being absorbed back into the membrane) exhibited gendered responses to pain signaling
SGIP1 Deletion in Mice Attenuates Mechanical Hypersensitivity Elicited by Inflammation
https://www.liebertpub.com/doi/abs/10.1089/can.2024.0020
In a rat model of oxidative stress, high doses of cannabis leaves caused lessened levels of antioxidant machinery
Effect of Cannabis Sativa Leaf on Oxidative Stress and the Recovery Period in Male Wistar Rats
https://assets-eu.researchsquare.com/files/rs-4686688/v1/bdf2f2aa-0a6a-496c-b89a-46d72cdd3f51.pdf?c=1720412195
In mice with pain from stress, this thesis project showed a combination of CBD & the terpene beta caryophyllene worked separately but not in conjunction
Exploring the Effects of Cannabidiol and Beta-Caryophyllene on Stress-Induced Allodynia in Mice
https://cedar.wwu.edu/wwu_honors/803/
Developing CBD nanocrystals for treating neuropathic pain
Potential analgesic effect of a novel cannabidiol nanocrystals powder for the treatment of neuropathic pain
https://onlinelibrary.wiley.com/doi/abs/10.1002/ejp.2300
For treating neuropathic pain from chemotherapy treatment, the drug licofelone (a COX/LOX inhibitor) appeared to lower pain via cannabinoid receptors
Licofelone, a Dual COX/LOX Inhibitor, Ameliorates Paclitaxel-Induced Mechanical Allodynia in Rats in a Cannabinoid Receptor-Dependent Manner
https://www.mdpi.com/2227-9059/12/7/1545
Guts & Metabolism
In public health data of young adults, current cannabis use was associated with a lower BMI but cumulative cannabis use or the cessation of cannabis was not
Associations of cannabis use and body mass index–The Coronary Artery Risk Development in Young Adults (CARDIA) study
https://www.sciencedirect.com/science/article/pii/S0953620524002899
In a human genetic analysis of stress & restricted food intake, different variants of the CB1 & FAAH genes altered weight, fat & restrictions in food intake
Genetic Evidence of Endocannabinoid System on Perceived Stress and Restricted Food Intake: The Role of Variants rs324420 in FAAH Gene and rs1049353 in CNR1 Gene
https://www.liebertpub.com/doi/abs/10.1089/can.2024.0077
A mouse model of type 2 diabetes & obesity, new drugs to target GPR119 (which may one day be known as CB4) increased GLP1 (the target of the new blockbuster obesity drugs like Ozempic)
Preclinical pharmacokinetics, pharmacodynamics, and toxicity of novel small-molecule GPR119 agonists to treat type-2 diabetes and obesity
https://www.sciencedirect.com/science/article/pii/S0753332224009612
In a mouse model of Type 1 diabetes, this thesis project showed water-soluble CBD to be effective at higher doses for lowering hyperglycemia
Study on Water-soluble Cannabidiol (CBD) Effects in Experimental Models of Type 1 Diabetes (T1D)
https://repository.stcloudstate.edu/cgi/viewcontent.cgi?article=1098&context=biol_etds
Reproduction & Hormones
Testing a female sexual hygiene product made from CBD in humans & rabbits found it caused only slight skin irritation
Safety assessment of female sexual hygiene product containing cannabidiol in new zealand white rabbit and clinical trial
https://www.sciencedirect.com/science/article/pii/S2214750024000751
In children exposed to tobacco prenatally, their lower attention scores & more impulsive behavior was not exacerbated by co-exposure to cannabis
Prenatal tobacco and tobacco-cannabis co-exposure: Relationship with attention and memory in middle childhood
https://www.sciencedirect.com/science/article/pii/S0892036224000539
In monkeys with prenatal THC exposure, they had lower heart weights & upregulated gene expression related to inflammation & carbohydrate metabolism
The effects of in utero exposure to delta-9-tetrahydrocannabinol (THC) on cardiac extracellular matrix expression and vascular transcriptome in rhesus macaques
https://journals.physiology.org/doi/abs/10.1152/ajpheart.00181.2024
In mice with prenatal cannabis exposure, females experience altered metabolic outcomes & adverse effects on glycemic control
Sex differences in the effects of maternal voluntary oral cannabis consumption on the metabolic outcomes of high fat diet in adult offspring
https://essopenarchive.org/doi/full/10.22541/au.172114297.76266976
In mice with prenatal cannabis exposure, this thesis project demonstrated an impact on dopamine & stress susceptibility in adolescence
Prenatal cannabis exposure impacts on VTA dopamine neuron physiology and adolescent stress susceptibility
https://prism.ucalgary.ca/items/4f2147a6-3e40-406e-b438-39c7bef674b7
In zebrafish with early exposure to THC, they had changes to their behavior, growth & brain mitochondrial levels
Early Developmental Exposure to Δ9-Tetrahydrocannabinol Causes Latent Behavioral, Growth, and Bioenergetic Effects in Danio Rerio
https://egrove.olemiss.edu/cgi/viewcontent.cgi?article=4082&context=hon_thesis
On ovary cells, THC altered their DNA methylation (the inactivation of genes) with a probable link to increased infertility
DNA methylation, but not microRNA expression, is affected by in vitro THC exposure in bovine granulosa cells
https://link.springer.com/article/10.1186/s40360-024-00763-5
The Heart
In a poster of a meta-analysis of major heart events & cannabis, the 24 articles showed an association just on the border of significance
Cardiovascular risk and use of cannabis or cannabinoids: a systematic review and meta-analysis
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/fcp.13015
As in, the link between cannabis use & negative heart events probably exists but probably also isn’t that strong.
In mice, a thesis project showed how CBD & CBG had modest effects on hemostasis (stopping of blood flow), lowered inflammation, did not harm their platelets & reduced platelet-white blood cell aggregations
The effects of phytocannabinoids cannabidiol and cannabigerol on platelet modulation, thrombus formation and inflammatory responses
https://centaur.reading.ac.uk/117258/
The Genitourinary System
In kidney patients, synthetic cannabinoid use disorder seemed to cause more harm than cannabinoid use disorder
Comparative analysis of addiction severity and renal functions in patients with synthetic cannabinoid use disorder versus cannabis use disorder
https://link.springer.com/article/10.1186/s43045-024-00442-5
For the bladder, a review of the importance of anandamide
Anandamide and the urinary bladder
https://www.minervamedica.it/en/journals/hellenic-urology/article.php?cod=R57Y2024N03A0108
The Skin
For acne, cannabinoids show promise against the bacteria Cutibacterium acnes
Anti Cutibacterium acnes properties from Cannabis sativa
https://ph01.tci-thaijo.org/index.php/PTUJST/article/view/256976
The Eyes
In retinal cells, the signaling of DAGL (the enzyme that produces 2-AG)
Diacylglycerol Signaling in Retinal Ganglion Cells
https://pubmed.ncbi.nlm.nih.gov/38977600/
Cancer & Chemotherapy
In people with neuropathy from chemotherapy, a topical CBD for two weeks did not improve pain but it was well tolerated
Topical Cannabidiol for Established Chemotherapy-Induced Neuropathy: A Pilot Randomized Placebo-Controlled Trial
https://www.liebertpub.com/doi/abs/10.1089/can.2023.0253
For racial disparities in cancer pain management, the potential role of cannabis
Potential role of cannabis in ameliorating observed racialized disparities in cancer pain management
https://pubmed.ncbi.nlm.nih.gov/38471103/
For anti-cancer activity, the power of these new CBD aromatic ester derivatives
Synthesis and antiproliferative activity of CBD aromatic ester derivatives
https://www.tandfonline.com/doi/abs/10.1080/14786419.2024.2369914
For ovarian cancer, a new drug that inhibits the MAGL enzyme (which breaks down 2-AG)
A carrier free delivery system of a MAGL inhibitor is effective on ovarian cancer
https://www.sciencedirect.com/science/article/pii/S0939641124002236
Synthetic Cannabinoids
In rats, chronic use of the synthetic cannabinoid JWH-018 caused heart problems & multiorgan tissue degeneration
Evidence for enduring cardiac and multiorgan toxicity after repeated exposure to the synthetic cannabinoid JWH-018 in male rats
https://www.sciencedirect.com/science/article/pii/S0300483X24001598
Using liver cells to find the breakdown products of ADMB-FUBIATA
Metabolic profiling of a new synthetic cannabinoid receptor agonist, ADMB-FUBIATA, with human liver microsomes, human primary hepatocytes and human recombinant CYP450 enzymes using LC-quadrupole-orbitrap MS
https://www.sciencedirect.com/science/article/abs/pii/S0731708524003820
On using machine learning to identify synthetic cannabinoids
Advances in the application of machine learning in the identification and authentication of synthetic cannabinoids
https://jcpu.cpu.edu.cn/en/article/pdf/preview/10.11665/j.issn.1000-5048.2023113003.pdf
Cool Chemistry & Tools
Sesame oil as a carrier for cannabinoids showed high stability
Long-term stability and bactericidal properties of galenic formulations of Cannabis sativa oils
https://pubmed.ncbi.nlm.nih.gov/39025316/
On creating CBD implants for long-term drug delivery
In situ forming PLA and PLGA implants for the parenteral administration of Cannabidiol
https://www.sciencedirect.com/science/article/pii/S0378517324007026
Modeling compounds that interact with opioid & cannabinoid receptors
COMPUTATIONAL MODELING OF COMPOUNDS THAT INTERACT WITH OPIOID AND CANNABINOID RECEPTORS
https://j.uctm.edu/index.php/JCTM/article/view/419
Enhancing CBD's oral bioavailability with nanoparticles
Enhanced oral bioavailability of cannabidiol by flexible zein nanoparticles: in vitro and pharmacokinetic studies
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1431620/full
And in edible oil blends
Enhanced bioavailability of cannabidiol via solubilization in edible oil blends
https://pubmed.ncbi.nlm.nih.gov/38990276/
The solubility of CBD in various solvents
Experimental investigation and thermodynamic modelling of cannabidiol and curcumin in different solvents
https://www.sciencedirect.com/science/article/pii/S016773222401568X
Thanks.
- lex
PS: For Fariña week, the simply splendid album he did with his wife Mimi called ‘Celebrations For A Grey Day’ (1965). Richard Fariña’s life of promise was cut short by tragedy. A Brookyln boy with a mother from Ireland & a father from Cuba, he started at Cornell as an engineering major before switching to English & writing for local literary magazines & even some national players. But then he was kicked out of school for being in a student demonstration. They eventually let him back in, but he dropped out right before graduation.
Instead, he began his ascent of the Greenwich Village folk scene by hanging out at the legendary White Horse Tavern. He became friends with Bob Dylan after the then little-known musician played harmonica on an album by Fariña’s first wife, Carolyn Hester. During a trip to Europe, he met Mimi Baez, the kid sister of Joan Baez. His first wife soon divorced him & he married Mimi. Their best man was Thomas Pynchon. Mimi & Richard played their first musical gig together at the Big Sur Folk Festival in 1964 & scored a contract with Vanguard Records that resulted in this album.
But these days, he’s best known for his novel referenced higher in the newsletter, ‘Been Down So Long It Looks Like Up to Me’, as much a protest novel as his music was protest music. Two days after the novel came out & on his wife’s 21st birthday, Richard was coming home from a book signing as a passenger on a motorcycle going far too fast & it went out of control & into a field. The driver survived but Fariña died instantly. As Ed Ward said, "If Richard had survived that motorcycle accident, he would have easily given Dylan a run for his money." Instead, he was buried under a simple grave with just his name & a peace sign.
This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.