C&P#122: arthritis, pain, fibro, MS’s spasticity & cancer
German finally sells some bud
This week…
For arthritis, cannabis improved stiffness, fatigue & swelling
For fibro, cannabis caused “important improvements”
Cannabinoids for pain pain pain + the spasticity of MS
In people with hep C, cannabis users had less liver cancer
Cannabinoids as antibiotics
For pancreatitis, contrary findings on cannabis use (kidneys too)
ASTM: canna-vapes leading to a “seismic event for cannabis waste”
CBD & cold brew coffee as an antioxidant
One Sasha Shulgin reference
Hello everyone,
Welcome to the 122nd edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science + assorted canna-news & psychedelic updates. Upgrade to a paid subscription here to support my work sharing canna-science. On the cannabinoids, ask me anything.
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Best Of Cannabinoid Science...
In CBD products, a profile of their most common minor cannabinoids
Minor Cannabinoid Profile of Unregulated Cannabidiol Products
https://www.liebertpub.com/doi/abs/10.1089/can.2024.0058
“The most frequently detected minor cannabinoids were CBDV (100% of samples tested), CBG (77%), CBC (72%), CBN (67%), CBL (67%), and CBDA (51%). Δ8-THC was not detected in any of the products tested. “
A Curaleaf sponsored study on the contaminants found in underground cannabis
The Hidden Dangers of Illicit Cannabis
https://e-space.mmu.ac.uk/636795/1/White-Paper-The-Hidden-Dangers-of-Illegal-Cannabis_FINAL-1.pdf
Clinical
In people with inflammatory bowel disease (IBD), ulcerative colitis patients who use cannabis had less intestinal surgeries & malnutrition while people with IBD who used cannabis had shorter hospital stays & less steroid use, intestinal obstruction, anemia, complications & mortality
Impact of Cannabis Use in Patients With Inflammatory Bowel Disease: Insights From the National Readmission Database 2019-2020
https://journals.lww.com/ajg/fulltext/2024/10001/s1087_impact_of_cannabis_use_in_patients_with.1088.aspx
I just did an 8’ video covering the science on Crohn's, colitis & IBD.
In people with arthritis, a survey reported cannabis use decreased pain with improvements in stiffness, fatigue & swelling
Patient-Reported Outcomes of Pain, Stiffness, and Fatigue Reduction in Rheumatoid and Psoriatic Arthritis With Cannabinoid Use
https://assets.cureus.com/uploads/original_article/pdf/204984/20241025-737028-e9vf8x.pdf
In case reports of twins with intractable epilepsy, they each achieved seizure suppression through different CBD regimens
Case reports of identical twins with developmental and epileptic encephalopathy with STXBP1 gene mutations for whom different CBD supplementations were markedly effective
https://www.sciencedirect.com/science/article/pii/S2589986424000777
In public health data on acute pancreatitis, cannabis users had lower mortality, sepsis, shock, need for blood transfusions, pancreatic drainage, acute respiratory failure & the need for an ICU stay but higher odds of GI bleeding, heart attacks, pancreatic insufficiency or pancreatic pseudocysts
The Cannabis Conundrum: Does Cannabis Use Worsen Clinical Outcomes in Acute Pancreatitis? A Propensity-Matched Nationwide Analysis
https://journals.lww.com/ajg/fulltext/2024/10001/s130_the_cannabis_conundrum__does_cannabis_use.131.aspx
And for the pancreas, cannabis-only users had higher odds of developing acute & chronic pancreatitis while those with alcohol abuse who use cannabis had lower odds of developing acute & chronic pancreatitis
Impact of Cannabis Use Disorder on In-Hospital Outcomes of Pancreatitis: A Nationwide Inpatient Study Stratified by Etiology
https://journals.lww.com/ajg/fulltext/2024/10001/s109_impact_of_cannabis_use_disorder_on.110.aspx
And a review that couldn’t find enough data to make an association between pancreatitis & cannabis use
Association of Marijuana Use and the Severity of Idiopathic Acute Pancreatitis
https://journals.lww.com/ajg/fulltext/2024/10001/s223_association_of_marijuana_use_and_the_severity.224.aspx
Confusing eh? And what does the pancreas even do?
It’s actually a two-faced organ. As a part of the digestive system, it produces enzymes that help us break down food, especially proteins. But as a member of the endocrine/hormone system, it produces the hormone insulin that controls blood sugar levels. So with the endocannabinoid system being so intimately tied up with both your digestive system & your hormone system, it makes sense that cannabis could have varying effects on this dual-use organ.
In people hospitalized with hepatitis C, those using cannabis had significantly lower odds of liver cancer
Cannabis Use and Risk of Hepatocellular Carcinoma Among Patients Hospitalized With HCV Using the National Inpatient Sample
https://journals.lww.com/ajg/fulltext/2024/10001/s1691_cannabis_use_and_risk_of_hepatocellular.1692.aspx
In breast reduction surgery, a retrospective review found no impact from cannabis use
Marijuana and Its Implications in Breast Reduction Surgery Outcomes and Quality of Life: A Matched Analysis
https://journals.lww.com/prsgo/fulltext/2024/11000/marijuana_and_its_implications_in_breast_reduction.10.aspx?context=latestarticles
In chronic cannabis users, they had alterations to their cortisol rhythms as well as significant decreases in cortisol & subjective stress
Multimodal examination of daily stress rhythms in chronic Cannabis users
https://link.springer.com/article/10.1007/s00213-024-06709-3
Unsurprisingly, anger more linked to alcohol & tobacco use then use of cannabis or the illegal drugs
Anger is more strongly associated with alcohol and tobacco use and use disorders compared to other substances in American adults
https://www.tandfonline.com/doi/full/10.1080/00952990.2024.2331721
Harms
(for reproductive harms, there’s so many this week that they’re all grouped together below in the ‘Reproduction & Hormones’ section)
A review for clinicians diagnosing potential problematic use of cannabis
Clinical Evaluation of the Cannabis-Using Patient: A Moving Target
https://www.thepermanentejournal.org/doi/full/10.7812/TPP/24.088
For cardiac arrhythmias (abnormal rhythm), a review about the increased risk from cannabis use
Arrhythmias and Cannabis Use: A Comprehensive Overview
https://www.sciencedirect.com/science/article/pii/S2666501824003660
For cannabinoid hyperemesis syndrome, interviews with 24 people about their experiences with the medical system & saying how the narratives around cannabis led them to resist treatment & to believe in a medical conspiracy to stigmatize it
Contesting Cannabinoid Hyperemesis Syndrome: How Narratives of Cannabis Shape Diagnosis Contestation and Treatment Resistance
https://journals.sagepub.com/doi/abs/10.1177/10497323241279079
A case report of vaping cannabis concentrate leading to pneumothorax (air in the chest cavity)
Pneumothoraces Associated With Vaping Cannabis Concentrate
https://publications.aap.org/pediatrics/article-abstract/154/5/e2024067278/199741/Pneumothoraces-Associated-With-Vaping-Cannabis
The medical term is vaping-associated spontaneous pneumothorax (VASP).
A case report of cannabinoid gummies causing lactic acidosis (a toxic buildup of lactic acid)
Acute Toxicity With Lactic Acidosis Associated With Cannabinoid Gummies
https://assets.cureus.com/uploads/case_report/pdf/305685/20241027-1067824-e9vf8x.pdf
“The patient described in this case report ingested a large number of edible cannabinoid gummies. He developed a sequence of toxic states that included lethargy, agitation, vomiting, tachycardia, hypertension, acute respiratory failure, and elevated lactic acid levels.”
A series of case reports of delta-8 THC gummies leading to psychosis
A Case Series: Psychotic Disorder Associated With Gummies Containing Delta-8-Tetrahydrocannabinol
https://pubmed.ncbi.nlm.nih.gov/39008848/
This probably did not involve the cannabis, but a case report of a young woman with severe food allergies who smoked cannabis & then kissed her boyfriend who had just eaten shellfish & went into shock & was declared brain dead seven days later
DRUGS AND KISSES: FATAL ANAPHYLAXIS FOLLOWING MARIJUANA SMOKING AND SHELLFISH EXPOSURE BY KISSING
https://www.annallergy.org/article/S1081-1206(24)01055-X/pdf
Reviews
For fibromyalgia, a review of 19 studies “showed an important improvement in pain, quality of life, and sleep habits” with no serios adverse events
Effectiveness and safety of cannabis-based products for medical use in patients with fibromyalgia syndrome: A systematic review
https://www.researchgate.net/publication/384815463_Effectiveness_and_safety_of_cannabis-based_products_for_medical_use_in_patients_with_fibromyalgia_syndrome_A_systematic_review
For the spasticity of multiple sclerosis, a review of 31 studies found the most commonly used medication to be nabiximols (1:1 THC:CBD sprays)
Cannabinoids for spasticity in patients with multiple sclerosis: A systematic review and meta-analysis
https://journals.sagepub.com/doi/full/10.1177/20552173241282379
For anxiety & CBD, a review of 11 clinical trials found “the data suggest that CBD may reduce anxiety with minimal adverse effects when compared to a placebo”
The Impact of Cannabidiol Treatment on Anxiety Disorders: A Systematic Review of Randomized Controlled Clinical Trials
https://www.mdpi.com/2075-1729/14/11/1373
For pain, a review of CBD’s clinical & preclinical evidence
Cannabidiol (CBD): A Systematic Review of Clinical and Preclinical Evidence in the Treatment of Pain
https://www.mdpi.com/1424-8247/17/11/1438
And a review of using cannabinoids for pain management
Exploring the Therapeutic Potential of Cannabinoid in Pain Management
https://crsubscription.com/journals/pharmacy/pharmacognosy/articles/2024/[132-139]-Cannabinoid-in-Pain-Management.pdf
And a review of 74 cannabinoid pain studies covering 12k+ people
Efficiency of cannabis and cannabidiol in managing chronic pain syndromes: A comprehensive narrative review
https://pubmed.ncbi.nlm.nih.gov/39499191/
“Cannabinoids were most effective in treating chronic secondary headache and orofacial pain, chronic secondary musculoskeletal pain, chronic secondary visceral pain, and chronic neuropathic pain.”
For chemotherapy & intestinal inflammation, a review of 81 articles on using cannabis to alleviate the symptoms
Medicinal Cannabis in Reducing Physical and Psychological Problems Caused by Chemotherapy and Intestinal Inflammation; Advantages and Challenges (A Review)
https://publish.kne-publishing.com/index.php/SSU/article/view/16851
For sleep apnea, a review of nine studies using cannabinoids
Cannabinoids for obstructive sleep apnea: A systematic review
https://pubmed.ncbi.nlm.nih.gov/39498540/
For microbial lung diseases, a review of using cannabis
Cannabis effectiveness on immunologic potency of pulmonary contagion
https://digital.zlb.de/viewer/metadata/1334908419/1/
For the kidneys, a review of the positive & negative effects of the cannabinoids
The effects of cannabinoids on the kidney
https://onlinelibrary.wiley.com/doi/abs/10.1111/apha.14247
For substance use disorders, a book chapter on the involvement of the endocannabinoid system
Substance Use Disorders and the Endocannabinoid System: A New Narrative
https://link.springer.com/referenceworkentry/10.1007/978-3-031-32035-4_140-1
Two review of the antibiotic effects of cannabis
A recent update on the antibacterial effects of distinct bioactive molecules derived from the Cannabis plant
https://akjournals.com/view/journals/1886/aop/article-10.1556-1886.2024.00098/article-10.1556-1886.2024.00098.xml
Cannabinoids as Antibacterial Agents: A Systematic and Critical Review of In Vitro Efficacy Against Streptococcus and Staphylococcus
https://www.mdpi.com/2079-6382/13/11/1023
And for MRSA (the staph infection stalking hospitals that kills more people in the US than AIDS), using machine learning to analyze the efficacy of cannabinoid derivatives
Modeling Antimicrobial Activity of Cannabinoid Derivatives Against MRSA: A QSAR Approach Using Machine Learning
https://www.researchgate.net/publication/385449998_Modeling_Antimicrobial_Activity_of_Cannabinoid_Derivatives_Against_MRSA_A_QSAR_Approach_Using_Machine_Learning
Preclinical
In humans skin cells, cannabinoid topicals reduced inflammation, promoted skin regeneration & improved structural functions
Exploring the Biological Activity of Phytocannabinoids Formulations for Skin Health Care: A Special Focus on Molecular Pathways
https://www.preprints.org/manuscript/202411.0319
In a female rat model of PTSD, CBD reversed impairments in fear extinction, reduced learned helplessness & suppressed neuroinflammation in the prefrontal cortex
Cannabidiol Modulates Neuroinflammatory Markers in a PTSD Model Conducted on Female Rats
https://www.mdpi.com/2218-273X/14/11/1384
In a mouse model of obesity, cannabis reversed the damage to the DNA & mitochondria (powerhouse of the cell)
Effects of THC-rich Cannabis sativa extract on Biochemical Parameters in Obesity
https://assets-eu.researchsquare.com/files/rs-5282770/v1/54f6aaaa-f271-4b42-9d23-6cd3aad3c7ea.pdf?c=1730273282
In a mouse model of Alzheimer's disease, the long term administration of PEA prevented cognitive impairment, preserved motivation & lowered neuroinflammation
Long-term administration of ultra-micronized PEA alters disease progression in the Tg2576 mice and reveals neuroprotective effects on behavior, brain morphology and biochemistry.
https://iris.uniroma1.it/handle/11573/1724714
In a mouse model of Parkinson's disease, the CBG derivative VCE-003.2 improved performance in motor tests, preserved neurons & reduced reactive microgliosis & astrogliosis (abnormally strong reactions from the microglia & astrocytes respectively)
Investigation in the cannabigerol derivative VCE-003.2 as a disease-modifying agent in a mouse model of experimental synucleinopathy
https://behavioralandbrainfunctions.biomedcentral.com/articles/10.1186/s12993-024-00256-9
In a rat model of hedonic effects, a thesis project showed THC increased the positive reactions to both sucrose & alcohol
Effects of voluntary ingestion of delta-9-tetrahydrocannabinol on the hedonic value of rewarding and aversive substances
https://krex.k-state.edu/items/90fef338-813f-4d41-95e8-e4baed64346c
In ovarian cancer cells, CBD, CBG & CBDA significantly reduced their viability with CBD being the most effective
Investigating Cannabis sativa bioactive compounds as an anti-cancer treatment in high-grade serous ovarian cancer
https://ijgc.bmj.com/content/34/Suppl_3/A88.2
And as always, there’s a half-dozen more studies below in the cancer section. The anti-tumor effects of the cannabinoids are one of their most under-utilized properties.
Novel Studies
(my new grab bag section for stuff I haven’t quite seen before)
For CBD & cold brew coffee, a thesis project on their synergistic antioxidant effects
Synergistic Interactions and Emulsion Preparation of Antioxidant Potential of Cannabidiol and Cold Brew Coffee
https://digitalcommons.montclair.edu/cgi/viewcontent.cgi?article=2424&context=etd
On how endocannabinoids regulate potassium channels
Endocannabinoid regulation of inward rectifier potassium (Kir) channels
https://pubmed.ncbi.nlm.nih.gov/39253376/
And in the heart sodium channels of a variety of species, the endocannabinoid ARA-S increased their activation
The endocannabinoid ARA-S facilitates the activation of cardiac Kv7.1/KCNE1 channels from different species
https://www.tandfonline.com/doi/pdf/10.1080/19336950.2024.2420651
In the husks of hemp seeds (a part of the plant not often studied), they contain phenylpropionamides that inhibit the enzyme tyrosinase (involved in melanin production, used to lighten skin & prevent severe skin diseases))
Inhibitory effects of phenylpropionamides from the hemp seed husk on tyrosinase
https://www.sciencedirect.com/science/article/abs/pii/S0141813024077481
In the Qihuang Zhuyu Formula (a Chinese herbal compound for coronary artery disease), it inhibits platelet activation by using the endocannabinoid system to alter the mitochondria (powerhouse of the cell) via the SIRT1/PPARα pathway
Qihuang Zhuyu Formula Modulates Mitochondrial Function to Inhibit Platelet Activation via Endocannabinoid Signaling Mediated by the SIRT1/PPARα Pathway
https://www.sciencedirect.com/science/article/pii/S0378874124013059
Another old treatment to add to our list of traditional remedies that use the endocannabinoid system for their positive effect.
the Headlines & Fav Articles
In Germany, first legal cannabis distribution
https://www.marijuanamoment.net/german-cannabis-club-distributes-first-legal-marijuana-to-members-as-officials-announce-broader-pilot-program-for-sales
Ukraine set to get medical cannabis from the EU
https://ukranews.com/en/news/1044988-eu-ready-to-supply-medical-cannabis-to-ukraine-health-ministry
An ASTM study finds that outdated cannabis packaging regulations make it impossible for the industry to be environmentally sustainable & that vapes are contributing to a seismic event for cannabis waste
https://www.marijuanamoment.net/outdated-marijuana-packaging-rules-make-it-impossible-for-cannabis-industry-to-be-environmentally-sustainable-study-says
A legal analysis on the evolution of gun rights & cannabis
Lawyers, Guns, and Marijuana: How N.Y. State Rifle and Pistol Ass'n v. Bruen is Shaping Federal Marijuana Law
https://scholarship.law.uc.edu/cgi/viewcontent.cgi?article=1546&context=uclr
A labor market analysis finds that a state implementing medical cannabis laws are significantly associated with less years of schooling, college attendance, employment & income
Long-Run Effects of Childhood Exposure to Medical Marijuana Laws on Education and Labor Market Outcomes
https://link.springer.com/article/10.1007/s12122-024-09365-w
The Laws, The War on Drugs & the End of Prohibition
On abolishing the DEA by Ifetayo Harvey of the People of Color Psychedelic Collective
Time to Abolish the DEA: E o Abolish the DEA: Evaluating the Agency aluating the Agency’s Failures and
Calling for Community Investments
https://ir.lawnet.fordham.edu/cgi/viewcontent.cgi?article=6113&context=flr
#EndTheDrugWarAlready
At pharmacy conferences, harm minimization talks are a must-see by some attendees & a turn-off to others
CONNECTING WITH HARM MIN: While harm minimisation can be a turn-off conference topic for some, for others it is pharmacy's equivalent of a must-see 'TED Talk'
link
In Canadian online drug markets, most of them don't bother accepting cryptocurrencies
Why don’t You Want My Money: A Study of the Acceptance of Cryptocurrencies in Online Cannabis Markets
https://www.tandfonline.com/doi/full/10.1080/01639625.2024.2418451
Business & Education
On how to incorporate cannabis into university curriculum
'Higher' education: Incorporating cannabis as interdisciplinary curricula
https://scholarworks.gvsu.edu/jti/vol14/iss1/1/
Hire me. I’ll teach ‘em Shulgin style.
A review of seed-to-sale systems
Review and Call for Improved Cannabis Measurement and the Potential for Leveraging Cannabis Seed-To-Sale Systems
https://www.tandfonline.com/doi/abs/10.1080/02791072.2024.2420042
In cannabis retailer marketing, exterior ads more common in lower income neighborhoods & warning signs more common in White neighborhoods
Neighborhood demographics in relation to marketing and regulation-related factors among cannabis retailers in 5 US cities
https://www.sciencedirect.com/science/article/abs/pii/S0376871624013966
An analysis of Canada's cannabis advertising ban
The 'ban' for public health that wasn't? Views and impressions on cannabis retail promotion/advertising realities amidst legalization policy in Canada
https://pubmed.ncbi.nlm.nih.gov/39266073/
The marketing factors on why people buy cannabis beverages
Marketing Factors Affecting to Decision Making on Buying Cannabis-Ingredients Beverages
https://www.researchgate.net/publication/377389958_Marketing_Factors_Affecting_to_Decision_Making_on_Buying_Cannabis-Ingredients_Beverages
In a Thai community, how to enhance the value of their cannabis economy
Empowering of Enterprise Group in Non Malai Community at Hin Lek Fai Subdistrict, Khu Mueang District, Buriram Province of Thailand to Enhance the Economy of Cannabis Processed Products
https://ecohumanism.co.uk/joe/ecohumanism/article/view/4540
Psychedelics, Plant Medicines & Other Psychoactives
The Department of Veteran Affairs announces their first psychedelic study since the 1960s: MDMA for veterans with PTSD & alcohol use disorder
https://www.marijuanamoment.net/top-va-official-announces-agencys-first-funded-psychedelic-study-for-veterans-since-the-1960s/?
The Plant & the History
Using genetics in the forensic analysis of cannabis
Leveraging genetics to support forensic toxicology analysis: Demonstrating concordance among marijuana samples
https://www.sciencedirect.com/science/article/pii/S2214786124000718
Growing & Processing
An analysis of the effects of light & plant density on yield
Harvesting Light: The Interrelation of Spectrum, Plant Density, Secondary Metabolites, and Cannabis sativa L. Yield
https://www.mdpi.com/2073-4395/14/11/2565
In a vertical farming system, increasing the yield with methyl jasmonate
Optimization of Cannabinoid Production in Hemp Through Methyl Jasmonate Application in a Vertical Farming System
https://www.mdpi.com/2311-7524/10/11/1165
In the cannabis types with larger leaf areas, when exposed to drought, they have a higher potential to adjust their stromata (openings in the leaf) to regulate gas exchange & respond to water deficit
Cannabis sativa genotypes with larger leaf areas have higher potential to adjust stomatal size and density in response to water deficit: The effect on stomatal conductance and physiological stomatal behaviour
https://www.sciencedirect.com/science/article/pii/S2667064X24003026
In the Northern Territory of Australia, high soil temperature reduced hemp germination
High soil temperature reduces hemp germination: Preliminary laboratory findings from Northern Territory
https://agronomyaustraliaproceedings.org/images/sampledata/2024/2024ASAvijayakumar_induni-25-1083-Vijaya_Kumar-Induni_Mahisha_Kumari.pdf
In the field, measuring terpene levels to identify higher cannabinoid yield cultivars
Scent Knows Better: Utilizing Volatile Organic Compounds as a Robust Tool for Identifying Higher Cannabidiol- and Tetrahydrocannabinol-Containing Cannabis Cultivars in Field Conditions
https://pubs.acs.org/doi/abs/10.1021/acs.jafc.4c06652
On using near-infrared to classify cannabis cultivars & predict cannabinoid & terpene concentrations
Comparative chemometric modeling of fresh and dry cannabis inflorescences using FT-NIR spectroscopy: Quantification and classification insights
https://pubmed.ncbi.nlm.nih.gov/39254142/
On collecting cannabis extracellular vesicles for biomedical uses
Characterization of cannabis plant-derived extracellular vesicles for biomedical applications
https://esmed.org/MRA/mra/article/view/5405
With the plant parts left after trimming, a water extract protected the prostate & had antimicrobial properties
Phytochemical profiling and biological evaluation of the residues from industrial hemp (Cannabis sativa L.) inflorescences trimming: Focus on water extract
https://www.sciencedirect.com/science/article/pii/S2212429224017759
Cannabis plants with multiple copies of their genome grew taller & had changes in their associated microbiomes
Exploring the Role of Endophytes in Cannabis sativa L. Polyploidy and Agricultural Trait Improvement
https://www.mdpi.com/2037-0164/15/4/78
In hemp field retting, the microbial communities that enhance fiber quality
Microbial communities and their role in enhancing hemp fiber quality through field retting
https://link.springer.com/article/10.1007/s00253-024-13323-y
In Thailand, the traits that affect seed yield from new germplasm
Identification of morphological traits affecting high seed yield potential from new hemp germplasm collected in Thailand
https://oes.chileanjar.cl/files/CJAR240325-85-1-2025.pdf
An analysis of the primary Thai cannabis cultivar
Evaluation of value adding components from postharvest biomass of Thai medicinal cannabis var. Hang Kra Rog Phu Phan
https://www.sciencedirect.com/science/article/abs/pii/S2214786124000664
A comparison of hemp cultivars grown in Australia’s Northern Territory
Industrial Hemp Variety Trials: Results from the Northern Territory
https://www.researchgate.net/publication/385355338_2023_Industrial_Hemp_Variety_Trials_Results_from_the_Northern_Territory
The diversity of wild hemp in the Himalayas
Geo-climatic factors co-drive the phenotypic diversity of wild hemp (Cannabis sativa L.) in the Potohar Plateau and Lesser Himalayas
https://link.springer.com/article/10.1186/s12870-024-05730-0
Food & Nutrition
Microencapsulating hemp leaf for feeding to animals to lower methane production
Bioefficiency of microencapsulated hemp leaf phytonutrient-based extracts to enhance in vitro rumen fermentation and mitigate methane production
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0312575
Industrial Uses & Fiber
On turning hemp waste into biogas
Enhancing biogas production from hemp biomass residue through hydrothermal pretreatment and co-digestion with cow manure: Insights into methane yield, microbial communities, and metabolic pathways
https://www.sciencedirect.com/science/article/abs/pii/S0301479724030251
Pollutant removal system using hemp fiber
Cationic waste hemp fibers-based membrane: Case study of anionic pollutants removal through environmentally friendly processes
https://www.sciencedirect.com/science/article/abs/pii/S0301479724031608
Hempcrete’s thermal & acoustic properties
Detailed characterisation of hemp and hempcrete pore structures: Effects on thermal and acoustic properties
https://www.sciencedirect.com/science/article/pii/S0008884624002837
Making a resin out of hemp fiber & the industrial waste filler dolomite dust
Processing and characterization of waste dolomite dust filled hemp-epoxy composites
https://onlinelibrary.wiley.com/doi/abs/10.1002/mawe.202300314
Using AI to predict the best hemp composite for automobiles
Development and machine learning based prediction of carbon/hemp/ramie sandwich composite as sustainable and ecofriendly solution for automobile application
https://www.sciencedirect.com/science/article/abs/pii/S2352492824027983
On extracting cellulose nanocrystals from hemp waste
Mechanical and morphological properties of cellulose nanocrystals extracted from industrial hemp agro-waste
https://link.springer.com/article/10.1007/s10570-024-06255-3
Stabilizing emulsion gels with hemp protein isolate
Novel high internal phase emulsion gels stabilized solely by hemp protein isolate: Enhancement of cannabidiol chemical stability and bioaccessibility
https://pubmed.ncbi.nlm.nih.gov/39245105/
How fire retardants affected hemp fiber composites
The impact of fire retardants on the mechanical and thermal characteristics of hemp fiber-reinforced polylactic acid composites
https://link.springer.com/article/10.1007/s12206-024-1022-z
The tensile strength of hemp fibers
Experimental and Statistical Investigations for Tensile Properties of Hemp Fibers
https://www.mdpi.com/2079-6439/12/11/94
A review of techniques for measuring hemp fiber length
A Brief Review of Hemp Fiber Length Measurement Techniques
https://www.mdpi.com/2079-6439/12/11/93
CANNABINOID SCIENCE
A review of the many cannabis delivery systems
Medicinal cannabis delivery systems: A perspective
https://accscience.com/journal/IMO/articles/online_first/2257
And a review of how different forms of cannabis alter its use & outcomes
Cannabis flower, concentrates, and edibles: a narrative review comparing prevalence of use, methods of consumption, and cannabis use disorder outcomes
https://www.tandfonline.com/doi/full/10.1080/10550887.2024.2418225
Saliva concentrations of THC after cannabis use
Concentrations of Delta 9-tetrahydrocannabinol (THC) in oral fluid at different time points after use: An individual participant meta-analysis
https://www.cell.com/heliyon/fulltext/S2405-8440(24)15904-X
Public Health
In women experiencing sexism, they had more cannabis use-related problems & coping-motivated-cannabis use
Sexism and Cannabis-Related Problems Among Women in the U.S.: The Role of Negative Affect and Coping-Motivated Cannabis Use
https://www.tandfonline.com/doi/abs/10.1080/10826084.2024.2422944
In Canada, surveys on why people might transition from illicit cannabis to regulated cannabis
Bridging the gap: Exploring consumer experiences and motivations for transitioning between illicit and regulated cannabis markets
https://www.sciencedirect.com/science/article/pii/S0955395924003281
COVID-19 led to an increase in home cannabis cultivation activity
Impact of the COVID-19 pandemic on cannabis cultivation and use in 18 countries
https://pure.au.dk/portal/en/publications/impact-of-the-covid-19-pandemic-on-cannabis-cultivation-and-use-i
A survey of how different medical providers talked to adult cannabis consumers
Patient-provider interactions about cannabis for therapeutic purposes vary as a function of provider type: A pilot study
https://pubmed.ncbi.nlm.nih.gov/39446729/
A survey of nurses working with medical cannabis patients found that they often wanted to talk about medicinal cannabis but did not always have the confidence to do so
An Exploration of Registered Nurses' Experiences Caring for Patients Taking Medicinal Cannabis
https://pmc.ncbi.nlm.nih.gov/articles/PMC11511588/
In Portuguese nurses & nursing students, the majority considered medical cannabis to be legitimate but the majority also had no knowledge of the endocannabinoid system & said they didn't have sufficient knowledge to advise on using medical cannabis
Knowledge and perspectives about medicinal cannabis in nurses and nursing students in Portugal
https://pmc.ncbi.nlm.nih.gov/articles/PMC11517285/
In US public health data, cannabis use rose in legal & medical states while tobacco use declined, but this change was not associated with legalization
Cannabis legalization and changes in cannabis and tobacco/nicotine use and co-use in a national cohort of U.S. adults during 2017–2021
https://www.sciencedirect.com/science/article/abs/pii/S0955395924003025
In Malaysia, interviews with pharmacists on legalizing medical cannabis
Decriminalizing and Legalizing Cannabis for Clinical Benefits in Malaysia: Perspective Among Pharmacists (A Qualitative Study)
https://www.tandfonline.com/doi/pdf/10.1080/02791072.2024.2420065
In Canada during the pandemic, older people who used cannabis reported higher loneliness scores
Loneliness and cannabis use among older adults: findings from a Canada national survey during the COVID-19 pandemic
https://link.springer.com/article/10.1186/s12889-024-20499-5
In Montana, estimates of cannabis use
Small Area Estimation using Multilevel Regression and Poststratification to Estimate Cannabis Use in the State of Montana
https://www.researchgate.net/publication/385522809_Small_Area_Estimation_using_Multilevel_Regression_and_Poststratification_to_Estimate_Cannabis_Use_in_the_State_of_Montana
On trying to establish a standard measure of blunt & cigar use for surveys
Establishing a standard measure of blunt and cigar use for U.S. national surveys
https://pubmed.ncbi.nlm.nih.gov/39255717/
And how adolescents tend to overestimate the amount of cannabis in their joints
Understanding US adolescents’ and emerging adults’ overestimation of their cannabis use quantity
https://www.sciencedirect.com/science/article/abs/pii/S0306460324002557
Adolescents & Young Adults
In youth of alternate sexual orientations, Two-Spirit, asexual, pansexual & queer identifying used more cannabis than those who identified as lesbian, gay & bisexual
The mediating effects of minority stress experiences on cannabis consumption among 2SLGBTQ+ youth
https://www.tandfonline.com/doi/abs/10.1080/19359705.2024.2394453
In sexual minority young adults, heterosexism-based stress induced cravings for cannabis, alcohol & nicotine
Vicarious heterosexism-based stress induces alcohol, nicotine, and cannabis craving and negative affect among sexual minority young adults: An experimental study
https://pubmed.ncbi.nlm.nih.gov/39252986/
For opiate maintenance, a thesis project survey of college students on cannabis being helpful
The Efficacy of Cannabis as a Substitute Addiction for Opiates
https://idun.augsburg.edu/cgi/viewcontent.cgi?article=2606&context=etd
Among young adults, the effect of cannabis on their sleep differed by their underlying mental health symptoms
Cannabis use and sleep problems among young adults by mental health status: A prospective cohort study
https://pubmed.ncbi.nlm.nih.gov/39476498/
“For participants without baseline anxiety or depression symptoms, using cannabis ≥ 20 days/month (versus never use) was associated with greater sleep problems at follow-up ... Among participants with anxiety and/or depression and pre-existing sleep problems at baseline, using cannabis ≥ 20 days/month (versus never use) was associated with fewer sleep problems at follow-up.”
Comparing 3 models of cannabis use & their relation to anxiety & depression in emerging adulthood
When Chilling Out Casts Doubt: Exploring the Temporal Associations Among Anxiety, Depression, and Cannabis Use in Emerging Adulthood
https://journals.sagepub.com/doi/pdf/10.1177/21582440241282182
“Regarding anxiety symptoms, some support was found for the vulnerability model [negative emotions precede cannabis use], in that anxiety preceded cannabis problems across some waves…. As for depression symptoms, there was support for reciprocal links between cannabis problems and depression across waves.”
In adolescents, a thesis project on the link between cannabis use & criminal behavior
Exploring the relationship between cannabis use in adolescence and propensity for criminal behaviour
https://www.um.edu.mt/library/oar/handle/123456789/127950
In Ontario youth, interviews on how to reduce the harms of cannabis use
Reducing the harms of cannabis use in youth post-legalization: insights from Ontario youth, parents, and service providers
https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-024-01112-9
The relationship between adolescent cannabis use & mental health does not seem to be moderated by maternal education
Does maternal education moderate the relationship between adolescent cannabis use and mental health in early adulthood?
https://pubmed.ncbi.nlm.nih.gov/39252481/
In adolescents using cannabis, the risk factors from their early family years
Preadolescent individual, familial, and social risk factors associated with longitudinal patterns of adolescent alcohol, cannabis, and other illicit drug use in a population-representative cohort.
https://psycnet.apa.org/record/2025-40553-001
In Canadian adolescents, the varied effects of cannabis legalization on their usage & impacts
Impacts and Implications of Cannabis Legalization on Key Outcomes Among Adolescents in Canada
https://journals.sagepub.com/doi/full/10.1177/07067437241293098
In Brazil, a chatbot for teaching young adults about the science around cannabis
Development, Content Validation and Usability of a Chatbot for Disseminating Scientific Information About Cannabis Among Young Adults
https://www.tandfonline.com/doi/abs/10.1080/02791072.2024.2421921
A mobile phone intervention to reduce cannabis driving among youth
Developing a mobile-based brief intervention to reduce cannabis-impaired driving among youth: An intervention mapping approach
https://www.sciencedirect.com/science/article/pii/S0955395924003104
Among Spanish adolescents, 10% in the last year had driven after using alcohol or cannabis
Prevalence and correlates of driving under the influence of alcohol and cannabis among Spanish adolescents
https://www.jsad.com/doi/abs/10.15288/jsad.24-00132
In Australia, the 2020 cohort more likely to be using cannabis than the 2019 cohort
Adolescent alcohol drinking and cannabis use: Longitudinal and cohort analysis of high school students in Australia
https://ijadr.org/index.php/ijadr/article/view/499/891
In young adults, cannabis use associated with starting to use electronic nicotine delivery systems
Cannabis use and associated longitudinal transitions in electronic nicotine delivery systems use among young adults in the United States
https://www.sciencedirect.com/science/article/abs/pii/S0306460324002405
The Brain & Neurological Disorders
A review of CBD for Parkinson's disease
CBD’s potential impact on Parkinson’s disease: An updated overview
https://digital.zlb.de/viewer/metadata/1346400695/1/
In mice, the endocannabinoid system regulates their production of saliva when exposed to the smell of food with a gendered response
Cannabinoid regulation of sex-dependent murine odorant-stimulated salivation
https://www.nature.com/articles/s41598-024-77761-4
In a rat model of stress, acute stress caused different changes to the levels of CB1 receptors in their hippocampus (brain memory center)
Acute stress induces different changes on the expression of CB1 receptors in the hippocampus of two lines of male rats differing in their response to stressors
https://www.sciencedirect.com/science/article/pii/S0091305724001953
In a mouse model of spinal damage, blockage of the CB1 & CB2 receptor increased the survival of spinal motor neurons
Selective blockade of cannabinoid receptors influence motoneuron survival and glial reaction after neonatal axotomy
https://www.sciencedirect.com/science/article/abs/pii/S0306452224005682
In a mouse model of excitotoxicity (overactivation of the brain), activating the CB1 receptor reduced neuroinflammation, brain swelling & blood-brain barrier permeability via the NOX‐2 pathway
CB1 Receptor Activation Provides Neuroprotection in an Animal Model of Glutamate‐Induced Excitotoxicity Through a Reduction of NOX‐2 Activity and Oxidative Stress
https://pmc.ncbi.nlm.nih.gov/articles/PMC11534500/
In a mouse model of Alzheimer's disease, genetically inactivating the FAAH enzyme (which breaks down anandamide) did upregulate inflammatory genes but it also lessened uptake of Aβ plaque by the microglia (guardian immune cells of the brain)
Fatty acid amide hydrolase gene inactivation induces hetero-cellular potentiation of microglial function in the 5xFAD mouse model of Alzheimer's disease
https://pubmed.ncbi.nlm.nih.gov/39474846/
In a mouse model of Alzheimer's, a FAAH/cholinesterase caused neuroprotection, lessened cognitive dysfunction & inhibited neuroinflammation via the microglia (guardian immune cells of the brain)
Natural phenol carbamates: Selective BuChE/FAAH dual inhibitors show neuroprotection in an Alzheimer's disease mouse model
https://www.sciencedirect.com/science/article/abs/pii/S0223523424008857
CBD binds to TRPC4 receptors & alters the excitability of neurons in the prefrontal cortex
Cannabidiol inhibits transient receptor potential canonical 4 and modulates excitability of pyramidal neurons in mPFC
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1431758/full
In astrocytes (brain support cells), cannabinoid receptor activation did not alter extracellular glutamate (the primary excitatory neurotransmitter)
Extracellular glutamate is not modulated by cannabinoid receptor activity
https://www.nature.com/articles/s41598-024-75962-5
A new radioactive CB2 agonist to measure CB2 levels in the brain
Development and Evaluation of Deuterated [18F]JHU94620 Isotopologues for the Non-invasive Assessment of the Cannabinoid Type 2 Receptor in Brain
https://advance.sagepub.com/doi/full/10.22541/au.172979832.20556552/v1
Mental Health, Addiction & Cannabis Use Disorder
In a New Zealand survey, people reported cannabis use led to less alcohol, morphine, methamphetamine & synthetic cannabinoid use, but some reported more tobacco use
Exploring the substitution of cannabis for alcohol and other drugs among a large convenience sample of people who use cannabis
https://pmc.ncbi.nlm.nih.gov/articles/PMC11536895/
For psychosis risk from cannabis legalization, a French review found mixed evidence from 7 studies
Impact of the legalization of recreational cannabis on the risk of psychosis: A systematic review of the literature
https://pubmed.ncbi.nlm.nih.gov/39244500/
“Four of the studies showed no increase in the use of health services for psychosis following the legalization of cannabis for recreational use whereas three other studies highlighted a negative impact of the legalization of cannabis for recreational use on the risk of psychosis. All of these studies were carried out in North America and were characterized by a low level of scientific evidence.”
In people with psychosis, a review of tech interventions to decrease their cannabis use
Technology-Based Psychotherapeutic Interventions for Decreasing Cannabis Use in People with Psychosis: A Systematic Review Update
https://www.liebertpub.com/doi/abs/10.1089/can.2024.0094
In people with anxiety & ADHD symptoms, they may be more inclined to use cannabis to self-medicate & reduce symptoms
Mental Health and Dispositional Predictors of Simultaneous versus Concurrent Cannabis and Alcohol Use in a Canadian Context
https://publications.sciences.ucf.edu/cannabis/index.php/Cannabis/article/view/256
In people with bipolar disorder, both cannabis use disorder & a night owl chronotype were associated with an earlier age of mood symptom onset
Co-morbid cannabis use disorder and chronotype are associated with mood symptom onset in people with bipolar disorder
https://www.sciencedirect.com/science/article/pii/S0022395624006277
In people going in for routine healthcare, those who used cannabis in the last year had higher measures of cannabis use disorder
Prevalence of Cannabis Use Disorder Among Primary Care Patients with Varying Frequency of Past-Year Cannabis Use
https://link.springer.com/article/10.1007/s11606-024-09061-6
In a mouse model of autism, raising the levels of the endocannabinoid 2-AG improved hyperactivity, inflammation, impaired social behaviors & cognitive deficits
Augmentation of Endogenous 2-Arachidonoylglycerol Mitigates Autistic Behaviors of BTBR Mice
https://link.springer.com/article/10.1007/s12035-024-04606-6
In mice, the behavioral effects of a CBD- & CBG-rich formula
Behavioral effects of two cannabidiol and cannabigerol-rich formulas on mice
https://www.cell.com/heliyon/fulltext/S2405-8440(24)15969-5
“CBG + formula produced an increase in mice locomotor activity and displayed anxiolytic properties, whereas both formulas improved spatial short-term memory and social interactions.”
In rats, tests of the neurocognitive effects of cannabis
Effects of Cannabis sativa on the Neuromuscular System and Cognitive Behavior of Male Wistar Rats
https://rojournals.org/wp-content/uploads/2024/10/ROJPHM-3251-58-2024-Zi.pdf
In an adolescent male rat model of methamphetamine use disorder, the CB1 receptor modulated methamphetamine-associated memories
Cannabinoid receptor type 1 agonist disrupts methamphetamine-induced conditioned place preference in adolescent male rats
https://www.sciencedirect.com/science/article/abs/pii/S0304394024004129
In neuronal tissue related to schizophrenia, cannabinoids decreased neuronal differentiation markers
Impact of cannabinoids on synapse markers in an SH-SY5Y cell culture model
https://www.nature.com/articles/s41537-024-00498-6
Pain, Musculoskeletal & Surgeries
After reviewing 66 YouTube videos on cannabis & chronic pain, these researchers said they found them to have a moderate quality & encouraged researchers to upload their own (what do you think I’m doing out here?)
Medical Misinformation and Quality of Public Video Content on Cannabis for Chronic Pain Management: A Cross-Sectional Analysis of the YouTube Platform
https://www.tandfonline.com/doi/pdf/10.2147/JPR.S479200
In people using opioids for pain, cannabis use was associated with poor functioning as well as probable depression, anxiety & PTSD
Alcohol, Tobacco, and Marijuana use Among Individuals Receiving Prescription Opioids for Pain Management
https://journals.lww.com/clinicalpain/abstract/9900/alcohol,_tobacco,_and_marijuana_use_among.217.aspx
In people with chronic pain receiving buprenorphine for opioid use disorder, discomfort intolerance was associated with cannabis use
Associations of discomfort intolerance, discomfort avoidance, and cannabis and alcohol use among persons with chronic pain receiving prescription buprenorphine for opioid use disorder
https://www.sciencedirect.com/science/article/abs/pii/S0376871624013978
In people using cannabis for pain, higher pain intensity & disability were associated with more hazardous cannabis use
Cross-Sectional Associations Between Expectancies for Cannabis use and Pain in an Emerging Adult Sample
https://journals.sagepub.com/doi/abs/10.1177/00472379241293748
In people with fibromyalgia, combining cannabis with oxycodone did not alter the painkilling power but did lower the doses of opioids
Cannabis combined with oxycodone for pain relief in fibromyalgia pain: a randomized clinical self-titration trial with focus on adverse events
https://www.frontiersin.org/journals/pain-research/articles/10.3389/fpain.2024.1497111/abstract
In people getting surgery on their dental pulp, a CBD-rich extract did not alter their pre- or postoperative anxiety
Effect of preoperative oral cannabidiol-rich Cannabis extract on anxiety and postoperative pain after endodontic treatment: A double-blind randomized clinical trial
https://www.sciencedirect.com/science/article/abs/pii/S0099239924005600
In a rat model of pain, CBD rich extract combined with achiote (a Central American shrub used in traditional medicine) reduced pain
Effect of the Association of Standardized Extracts of Cannabis sativa L. (CBD) with Bixa orellana L. (Chronic® and Chronic In®) on Pain Models in Wistar Rats
https://www.preprints.org/manuscript/202410.2348/v1
In a mouse model of neuropathic pain, activating the CB2 receptors in the hippocampus (memory center of the brain) reduced the cognitive impairment via the DUSP6/ERK/NFκB pathway
Hippocampal cannabinoid type 2 receptor alleviates chronic neuropathic pain-induced cognitive impairment via microglial DUSP6 pathway in rats
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.202401481R
In a mouse model of pain, those without CB2 receptors did not develop tolerance to morphine but they did exhibit more drug-seeking behavior
Impact of Genetic and Pharmacological Modulation of CB2 Receptors on Morphine-Induced Analgesia, Tolerance, and Reward in C57BL/6J Mice
https://www.sciencedirect.com/science/article/pii/S2667242124000915
In a mouse model of migraines, zolmitriptan patches reduced pain via the CB1 receptors
Zolmitriptan niosomal transdermal patches: combating migraine via epigenetic and endocannabinoid pathways and reversal of migraine hypercoagulability
https://link.springer.com/article/10.1007/s13346-024-01731-6
Guts, Metabolism & Oral Health
For type 2 diabetes, on the potential of drugs targeting GPR119 (a receptor that may one day be known as a cannabinoid receptor)
What is holding back preclinical GPR119 agonists from their potential as the therapeutics of type 2 diabetes?
https://www.tandfonline.com/doi/full/10.1080/14728222.2024.2421751
The gut bacteria Faecalibacterium prausnitzii produces the FAAH enzyme
A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase
https://www.science.org/doi/abs/10.1126/science.ado6828
Immune System & Microbial
In people going in for psychiatric treatment, those using cannabinoids had significantly higher levels of neutrophils (a type of white blood cell that fights infection)
Differences in total and differential WBC counts and in inflammatory parameters between psychiatric inpatients with and without recent consumption of cannabinoids, opioids, or cocaine: a retrospective single-center study
https://www.sciencedirect.com/science/article/pii/S2666354624001765
Reproduction & Hormones
Five-year-old children with prenatal cannabis exposure had poorer task-based planning ability & more observed aggression
Prenatal Cannabis Exposure and Executive Function and Aggressive Behavior at Age 5 Years
https://jamanetwork.com/journals/jamapediatrics/article-abstract/2825405
Fetal exposure to THC tends to be lower than maternal exposure & perhaps it's because THC & its metabolites inhibit one of the placental drug transporters
Are Δ9-Tetrahydrocannabinol and Its Major Metabolites Substrates or Inhibitors of Placental or Human Hepatic Drug Solute-Carrier Transporters?
https://www.mdpi.com/1422-0067/25/22/12036
In California, adult use cannabis laws were associated with an increase in cannabis use during early pregnancy
Cannabis Use During Early Pregnancy Following Recreational Cannabis Legalization
https://jamanetwork.com/journals/jama-health-forum/fullarticle/2825387
People with depression during their pregnancy were more likely to be using cannabis
Predictors of perinatal cannabis use in colorado and the association with depression during pregnancy
https://link.springer.com/article/10.1007/s00737-024-01515-4
A review of outcomes of maternal cannabis use during pregnancy
Maternal Cannabis Use During Pregnancy and Maternal and Neonatal Adverse Outcomes
https://www.psychiatrist.com/jcp/maternal-cannabis-use-pregnancy-adverse-maternal-neonatal-outcomes/
In mice with prenatal exposure to CBD, they had decreased survival to weaning age, lower body weight in males as well as perinatal CBD use leading to less anxiety in females & less long-term object memory in males
Maternal ingestion of cannabidiol (CBD) in mice leads to sex-dependent changes in memory, anxiety, and metabolism in the adult offspring, and causes a decrease in survival to weaning age
https://www.sciencedirect.com/science/article/pii/S0091305724001965
The Heart
A review of the effects of cannabis on the heart [German]
Effects of cannabis use on the heart
https://link.springer.com/article/10.1007/s00059-024-05282-x
In a rat model of high blood pressure, four weeks of injections of AM251 (a blocker of the CB1 receptor)into the hypothalamus (key brain regulator of bodily functions) significantly decreased heart rate, blood pressure & body weight as well as lowered CB1 levels & proinflammatory cytokine release via the Wnt/β-catenin/RAS pathway
Inhibition of CB1R in the Hypothalamic Paraventricular Nucleus Ameliorates Hypertension Through Wnt/β-Catenin/RAS Pathway
https://link.springer.com/article/10.1007/s12012-024-09938-2
The Liver
In elderly people with acute liver failure, those with cannabis use disorder had more liver-related hospitalizations but a lower mortality rate, “possibly due to the endocannabinoid system's role in reducing liver inflammation and fibrosis”
Higher Prevalence but Lower Mortality in Acute Liver Failure-Related Hospitalizations in Elderly Cohort With Cannabis Use Disorder: A Population Based Analysis
https://journals.lww.com/ajg/fulltext/2024/10001/s1850_higher_prevalence_but_lower_mortality_in.1851.aspx
In a mouse model of liver damage from diabetes, the combination of PEA & rutin protected inflammation & oxidative damage
Co-Micronized Palmitoylethanolamide and Rutin Associated With Hydroxytyrosol Recover Diabesity-Induced Hepatic Dysfunction in Mice: In Vitro Insights Into the Synergistic Effect
https://pubmed.ncbi.nlm.nih.gov/39474783/
In a mouse model of non-alcoholic fatty liver disease, the combination of a drug that activates the CB2 receptor & two PPAR receptors (which regulate genetic transcription) suppressed obesity, inhibited visceral fat tissue expansion, reduced fat inflammation & lowered intestinal inflammation & injury
Chronic Peroxisome Proliferator-Activated Receptor α/γ and Cannabinoid Receptor 2 Agonist Treatments Attenuated Visceral Adipose Tissue (VAT)–Derived Extracellular Vesicle–Related VAT and Intestinal Abnormalities in Nonalcoholic Steatohepatitis Mice
https://ajp.amjpathol.org/article/S0002-9440(24)00398-5/abstract
The Genitourinary System
In rats, their kidneys were protected from cannabis-induced toxicity via diets of turmeric & ginger
Mitigating Marijuana-Induced Nephrotoxicity: The Role of Selected Local Spice Diets in Wistar Rats
https://www.seahipublications.org/wp-content/uploads/2024/10/IJIBMR-D-1-2024.pdf
The Skin
In cannabis cosmeceuticals, a review of their anti-inflammatory & antioxidant effects
Investigation of the anti-inflammatory and antioxidant properties of cannabis in cosmeceuticals
https://aestheticcosmetology.com/wp-content/uploads/2024/10/ACM-2024-05-vG-Basit-EN.pdf
In skin cells exposed to ethanol, CBD protected them from the depressed metabolism & higher levels of apoptosis (programmed cellular suicide) via changes to genetic transcription
Cannabidiol (CBD) modulates the transcriptional profile of ethanol-exposed human dermal fibroblast cells
https://link.springer.com/article/10.1007/s13353-024-00915-7
In a mouse model of allergic inflammatory skin disease, a drug that blocks the GPR55 receptor (which may one day be known as CB3) suppressed symptoms via regulation of the immune system
GPR55 antagonist CID16020046 suppresses DNCB-induced atopic dermatitis-like symptoms by suppressing Th1/Th2/Th17 populations in mice
https://www.sciencedirect.com/science/article/abs/pii/S0014299924007787
Cancer & Chemotherapy
A survey of why & who are using cannabis during cancer treatment
Cannabis Use Among Cancer Patients During Active Treatment: Findings From a Study at an NCI-Designated Cancer Center
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cam4.70384
In people with colon cancer, people using cannabis had larger polyps & more of them through the significance disappeared after controlling for gender, smoking, race & alcohol use
Association of Marijuana Use With Colorectal Neoplasia
https://journals.lww.com/ajg/fulltext/2024/10001/s470_association_of_marijuana_use_with_colorectal.471.aspx
An Ayurvedic review of cannabis for cancer management
Ayurvedic Concept Of Cancer Diagnosis And Its Management With Cannabis-Based Herbal Drugs
https://www.researchgate.net/publication/385282043_Ayurvedic_Concept_Of_Cancer_Diagnosis_And_Its_Management_With_Cannabis-Based_Herbal_Drugs
A review of how cannabinoids exhibit anti-cancer properties & how they can be utilized for cancer therapy
How do specific cannabinoids exhibit anti-cancer properties, and what strategies can be employed to optimize their efficacy for targeted cancer therapies?
https://escholarship.org/content/qt6mg3r54p/qt6mg3r54p_noSplash_244001c24080f7adff4bbb8aa27bb62b.pdf
In breast cancer cells, Lebanese cannabis extract induced apoptosis (programmed cellular suicide)
The molecular anti-metastatic potential of CBD and THC from Lebanese Cannabis via apoptosis induction and alterations in autophagy
https://www.nature.com/articles/s41598-024-76340-x
In cancer cells, an RNAi analysis found the CB1 receptor agonist WIN55212-2 combined well with targeting the tyrosine receptor kinase AXL to inhibit tumor growth
RNAi Screen Identifies AXL Inhibition Combined with Cannabinoid WIN55212-2 as a Potential Strategy for Cancer Treatment
https://www.mdpi.com/1424-8247/17/11/1465
Synthetic Cannabinoids & Hemp-Derived Cannabinoids
On measuring synthetic cannabinoids & their metabolites in human blood & urine
Simultaneous quantification of JWH-018, JWH-073, and their metabolites (4-OH JWH-018, 3-OH JWH-073) in human plasma and urine samples by LC-MS/MS
https://www.tandfonline.com/doi/abs/10.1080/10826076.2024.2414026
On detecting synthetic cannabinoids in oral fluids
Bar adsorptive microextraction and liquid chromatography-diode array detection of synthetic cannabinoids in oral fluid
https://pubmed.ncbi.nlm.nih.gov/39259273/
The effects of the synthetic cannabinoid MDA-19 on zebrafish development
Effects of MDA-19 on Zebrafish Larval Behavior: Perspectives From Neurodevelopment, Oxidative Stress, and Metabolomics
https://pubmed.ncbi.nlm.nih.gov/39477463/
A Twitter analysis found that all states are talking about delta-8 THC regardless of cannabis legality
Is Delta-8-THC use associated with state-level cannabis policies? A content analysis from different jurisdictions in the United States
https://www.jsad.com/doi/abs/10.15288/jsad.24-00297
Cool Chemistry & Tools
How is the GPR55 receptor activated? (this receptor may one day be known as CB3)
Structure basis of ligand recognition and activation of GPR55
https://www.nature.com/articles/s41422-024-01044-w
Using flow chemistry to synthesize minor cannabinoids
Minor Cannabinoid Synthesis by Flow Chemistry
https://journals.sagepub.com/doi/pdf/10.1177/1934578X241285209
An electrochemical sensor for measuring cannabinoid levels
Surfactant-assisted electrochemical sensor for phytocannabinoids
https://www.sciencedirect.com/science/article/abs/pii/S0026265X24021672
For wastewater remediation, a thesis project on a technique for removing cannabinoids
Radical Redox Kinetics of Tetrahydrocannabinol and Associated Metabolites Through Advanced Oxidative Process for Wastewater Remediation
https://www.proquest.com/openview/d003aa10756d9cc0c41ea114a2714251/1?pq-origsite=gscholar&cbl=18750&diss=y
Thanks.
- lex
PS: For this week’s sublime singer of bossa nova, Elizete Cardoso’s ‘Canção Do Amor Demais’. Known to Brazilian audiences as ‘A Divina’ (the Divine One), she not only launched the bossa nova movement with this album & was one of great samba singers of all time, she was also an actress of great renown & the first singer to interpret the classical music of the legendary Heitor Villa-Lobos ("the single most significant creative figure in 20th-century Brazilian art music") at the Municipal Theaters of São Paulo & Rio. After each of those performances, she received a 15-minute standing ovation. Producing over 40 albums in her lifetime, Elizete Cardoso certainly deserved her other nickname of ‘A Magnifica’ (the Magnificent One).
This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.