C&P#126: Big News with the CHRI! + canna-vaginal suppositories, young people with cancer & much on CBD for the brain

Word: UN High Commissioner for Human Rights: "so-called War on Drugs has failed, completely and utterly"

Dec 16, 2024

For survivors of gynecological cancer, cannabis vaginal suppositories improved sexual function
Young adults with cancer using cannabis to relieve symptoms
CBD for elderly vascular dementia
For rare genetic disorders of seizures & pain, case reports of CBD
CBD lozenges against the bacteria that cause cavities
For male fertility, is THC bad & CBD good?
More on prenatal cannabis use & autism
For adolescent cannabis users, a meta-analysis links to worse academic achievement
The ECS & the sensation of itching as well as producing tears
Ketamine works via the ECS? And caloric restriction too?
A meta-analysis of psychedelic-induced psychosis suggests perhaps schizophrenia shouldn’t be an exclusion criteria for human trials
New word of the week: aquaphotomics
To help the bees, using hemp to remove forever chemicals from soil
Two papa jokes. Maybe more, depending on how you count…
(my kids would say zero)

Hello everyone,
Welcome to the 126^th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science + assorted canna-news & psychedelic updates. Upgrade to a paid subscription here to support my work sharing canna-science. On the cannabinoids, ask me anything.

Editor’s note: new sponsor!
Two pieces of great news: I’m back on LinkedIn for reasons unknown + I’ve found a new project for me as well as a primary sponsor for this newsletter: the Cannabis and Health Research Initiative.
Run by Johns Hopkins & the Realm of Caring, this health project will pay people to talk about their use of cannabis to generate data (you can sign up to participate here & you’ll get $100 for ~2 hours of surveys over the next year & the satisfaction of adding to our knowledge of cannabis use in the real world). They have a searchable Research Library of 2500+ studies & you can also help out by showing love to their IG page.
My initial job will be writing their monthly newsletter & you can sign up for it here. It’ll contain the best of data from this newsletter as well as a focus on medical cannabis news. I’m aiming to make it useful & accessible for healthcare practitioners. And I plan to get creative about how to get people to sign up to participate in this study & if anyone knows any organizations who would want to help spread the word, I’m glad to talk with anyone who wants to help.

Also, I wanted to say many thanks to Denise C & Erik S for their generous donation in upgrading to a yearly paid subscription of this newsletter. If you’d like to support this newsletter for your end-of-the-year giving, you can subscribe here or donate at the links below.

Free resources

CVResearch.info: the extensive cannabinoid science archive I maintain for CV Sciences & our new canna-edu video series on YouTube @CVScienceInc & on TikTok @pluscbd
Read my free How-To Guides or watch my 3-Minute Cannabinoid Science videos on YouTube or read my canna-science journalism here
As always, here’s the Glossary of Cannabinoid Terms & at the bottom is the album of the week

For more from Lex… (my Linktree)

Work with my company White Whale Creations to produce content for cannabis & psychedelic companies: writing, science archives, social media content, newsletters & podcasts: my portfolio
My canna-graphic novels: On Amazon, buy ‘SUNset’, my Queer cannabis history graphic novel or ‘The CROWN’, the story of the hunt for the structure of CBN. To see more about this series of canna-graphic novel series based on Moby Dick, see lexpelger.com
Listen to the first 2 seasons of my podcast ‘The Lex Files’ on cannabinoids, psychedelics & spirituality

A request to spread the word
This newsletter only spreads by word of mouth,
so please forward to colleagues & tell your friends & relatives.

Sponsor: Your Canna-Graphic Novel Holiday Gift Guide!

I’ve got three recommendations for the canna-person in your life who likes graphic novels:

‘Brittle Joints’ by Maria Sweeney: This is one of the most convincing & well-done canna-graphic novels I’ve seen in my lifetime of collecting both graphic novels & writings of cannabis experiences. Born with a severe brittle bone disease, Maria illustrates her own book to tell the story of growing up with the challenges of easily broken bones & the transformative power of cannabis to help her with pain.
I’m going to do a video review of this book soon, but for now, you can see lots of highlights on her Instagram & I especially loved this page where I learned that you can roll your joints up with rose petals for a sweet smoke. Two thumbs up. A simply fantastic piece of work.
You can also support her Patreon page here.
Love canna-science history? A fan of elephants? Hate the War on Drugs?
Then have we got a graphic novel for you, ‘The CROWN: Or; How to Shoot an Elephant’ from the graphic novel series ‘Anandamide, or; the Cannabinoid’. Starting in the 1860s, scientists started trying to isolate the active ingredient from cannabis. But it took until the 1940s for a cannabinoid’s structure to be fully solved. With elephants, writer & scientist Lex Pelger uses the metaphor of the blind men & the elephant to explain how we finally discovered the structure of cannabinol (CBN).
A visual feast of classic imagery arranged by the Peruvian illustrator & witch Wayra Sumacc, you can see a sample here & buy the book here.
(this link is Amazon.com but should be available in all markets)
Love Queers? Believe in medical cannabis? Want to know how truly horrible Reagan was on AIDS & how truly spectacular for widening the Drug War to terrible proportions?
Then read ‘SUNset’, Lex Pelger’s history on how the AIDS crisis of the ‘80s sparked the birth of the medical cannabis movement in the US. Heroic activists, vicious local opposition & a big tribute to Kushner’s ‘Angels in America’, this is a heartbreaking story about dedicated activists like Brownie Mary who changed the world. See a sample here & buy the book here.

My work this week:

CV Sciences Canna-Edu Vids:
(on YT @CVSciencesInc & TT @pluscbd)

Long videos:

Neuropathic Pain & the Many Cannabinoids
(or see the new Neuropathic Pain page on CVResearch.info)

Short videos:

My Vids:
(on TT @lexpelgerandhisbooks or on YouTube)

AI for Cancer & Floods

Ways to support this work:

A paid subscription on Substack
Buy Me a Coffee
Venmo: @Lex-Pelger
PayPal: donate here

Best Of Cannabinoid Science...

All of the abstracts from the International Conference on the Science & Practice of Medical Cannabis (May 2024 in London)
https://ct-cann2024.com/wp-content/uploads/sites/124/2024/05/CT-Cann2024-Abstract-Book.pdf

Clinical

In survivors of gynecological cancer, a combination of cannabis suppositories & a mindful compassion group intervention reduced sexual pain & improved sexual function, including arousal, lubrication & orgasms
A Preliminary Investigation into the Use of Cannabis Suppositories and Online Mindful Compassion for Improving Sexual Function Among Women Following Gynaecological Cancer Treatment
https://www.mdpi.com/1648-9144/60/12/2020

In elderly people with vascular dementia (cognitive problems from impaired blood flow to the brain), one month of 300 milligrams of CBD per day reduced psychological & behavioral symptoms with only mild, transient adverse events
Effects of cannabidiol on behavioral and psychological symptoms of vascular dementia: a randomized, double-blind, placebo-controlled trial
https://www.cambridge.org/core/journals/international-psychogeriatrics/article/p25-effects-of-cannabidiol-on-behavioral-and-psychological-symptoms-of-vascular-dementia-a-randomized-doubleblind-placebocontrolled-trial/A82EE91A21C33A9581034845D6BE4FDC

In young adults with cancer, a survey of their characteristics & why they used it (managing sleep disturbances (69%), pain (62%) or mood disorders (42%))
Medical cannabis use in young adults with cancer: a self-reported survey study
https://pubmed.ncbi.nlm.nih.gov/39366693/
For some reason, these authors seem to assume that cannabis use here is a bad thing despite the large number of patients telling them that it helped.

In a human study of oral Streptococcus mutans (the bacteria linked to tooth decay), 15 days of a lozenge infused with 300 mg of CBD significantly reduced bacterial levels
Antimicrobial Effects of Cannabidiol (CBD)-infused Lozenges against Streptococcus mutans in Oral Health
https://www.scielo.br/j/bdj/a/WZ7rQGBjyWXNtHkK9nYBbsB/

In people intensely exercising, low doses of CBD inhibited exercise-induced liver activity with no evidence for liver toxicity
Short-term repeated oral intake of low dose cannabidiol: effects on liver enzyme activity and creatinine concentration during intense exercise
https://link.springer.com/article/10.1007/s00204-024-03904-1

In extracts versus sprays of THC & CBD, an analysis of how they moved through humans, with sprays being significantly more potent in males
A Preliminary Pharmacokinetic Comparison of Δ-9 Tetrahydrocannabinol and Cannabidiol Extract Versus Oromucosal Spray in Healthy Men and Women
https://www.liebertpub.com/doi/abs/10.1089/can.2023.0249

In Canada, cannabis legalization was linked to significant reductions of emergency department visits for schizophrenia
The impact of recreational cannabis legalization on cannabis-related acute care events among adults with schizophrenia
https://pubmed.ncbi.nlm.nih.gov/39387895/
And legalization was not linked to an increase in opioid-related deaths
Legal Recreational Cannabis Sales and Opioid-Related Mortality in the 5 Years Following Cannabis Legalization in Canada: A Granger Causality Analysis
https://publications.sciences.ucf.edu/cannabis/index.php/Cannabis/article/view/261

In postmortem analysis, in people who died by suicide & who had alcohol use disorder or mood disorders, they had increased CB1 receptor levels in their prefrontal cortex while the opposite was observed in people with schizophrenia treated with antipsychotics
The Neurobiology of Pain, Emotion, and Stress Regulation in Suicide: Role of Cannabinoid, Opioid, Vanilloid, and Galaninergic Systems – A Systematic Review of Postmortem Evidence
https://link.springer.com/article/10.1007/s11469-024-01419-5

Case Reports

In rare epilepsy with myoclonic-atonic seizures, two pediatric case reports of using CBD for rapid seizure freedom
Rapid seizure resolution with cannabidiol in medically refractory epilepsy with myoclonic-atonic seizures
https://pubmed.ncbi.nlm.nih.gov/39641913/

In a case report of a child with Klippel-Trenaunay syndrome (a painful genetic condition with the overgrowth of skin, veins, tissues & bones), THC helped with the intractable pain & improved quality of life
Compassionate use of medicinal Cannabis for pain treatment in children with Klippel-Trenaunay Syndrome. Case report
https://www.scielo.br/j/brjp/a/ftkx9x6mVNz8wGjmwJsCpZh/

In a case report of Angelman syndrome (a rare genetic disease of the nervous system with severe physical & learning disabilities as well as seizures), CBD stopped the seizures
Successful use of cannabidiol in nonconvulsive status epilepticus in Angelman syndrome
https://pubmed.ncbi.nlm.nih.gov/39175208/

Harms

Pushback from Dr. Tashkin on the recent study linking cannabis to head & neck cancer
Clarification Regarding the Association of Cannabis Use and Head and Neck Cancer
https://jamanetwork.com/journals/jamaotolaryngology/article-abstract/2826634

For autism & prenatal cannabis exposure, a nuanced look at the effects from public health data
Associations of maternal peripregnancy cannabis use with behavioral and developmental outcomes in children with and without symptoms of autism spectrum disorder: Study to Explore Early Development
https://pubmed.ncbi.nlm.nih.gov/39660543/
“Preconception-only cannabis use (versus no use) was associated with more aggressive behavior, emotional reactivity, and sleep problems in children with ASD symptoms, but not in children without ASD symptoms. Cannabis use during pregnancy was associated with increased attention and sleep problems in children with ASD symptoms; these associations did not differ significantly by ASD symptoms. Peripregnancy cannabis use was not associated with child developmental abilities regardless of ASD symptoms.”

For adolescent cannabis users & their academic achievement, a large meta-analysis of 63 studies covering 400k+ people found that “cannabis use during adolescence and young adulthood was probably associated with increases in school absenteeism and dropout; reduced likelihood of obtaining high academic grades, graduating high school, enrolling in university, and postsecondary degree attainment; and perhaps increased unemployment”
Cannabis Use During Adolescence and Young Adulthood and Academic Achievement: A Systematic Review and Meta-Analysis
https://pubmed.ncbi.nlm.nih.gov/39374005/
Of course, the question is always the chicken or the egg. Would these kids already have been low academic achievers because of the other things in their background that are also linked to early cannabis use? Or does cannabis make them more leery of the academic rat race? Or does it simply make them worse at school because of the memory & attention issues? As usual, it’s probably a mix of everything.
So will I encourage my teens to use grass? No. But will I hit the wall if they do? Also no.

In public health data from the UK Biobank, in both people with & without a high genetic risk for schizophrenia, high-potency cannabis use was a strong predictor of a psychotic disorder
The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/274AF7839E20F0EED1F805FD2CD2FC57/S0033291724002058a.pdf/impact_of_schizophrenia_genetic_load_and_heavy_cannabis_use_on_the_risk_of_psychotic_disorder_in_the_eugei_casecontrol_and_uk_biobank_studies.pdf

For psychosis from cannabis withdrawal, a case series of four patients with psychotic features after abrupt cannabis withdrawal
New insight in psychotic cannabis withdrawal: case series and brief overview
https://www.rivistadipsichiatria.it/archivio/4386/articoli/43840/

On the mycotoxins in contaminated cannabis, a cellular analysis of harms include DNA damage
Assessing the Potential Synergistic/Antagonistic Effects of Citrinin and Cannabidiol on SH-SY5Y, HepG2, HEK293 Cell Lines, and Human Lymphocytes
https://www.mdpi.com/2072-6651/16/12/534

Reviews

For Alzheimer's, a review of using CBD
EFFICACY OF CANNABIDIOL (CBD) IN THE TREATMENT OF ALZHEIMER’S DISEASE: A CRITICAL REVIEW OF EVIDENCE AND CLINICAL IMPLICATIONS
https://revistaft.com.br/efficacy-of-cannabidiol-cbd-in-the-treatment-of-alzheimers-disease-a-critical-review-of-evidence-and-clinical-implications/

For male fertility, this review suggested THC to have negative effects (reduced sperm quality, altered hormone levels, changes in genetic & epigenetic profiles) & CBD to be protective (anti-inflammatory & antioxidant)
Do Delta-9-tetrahydrocannabinol and Cannabidiol have opposed effects on male fertility?
https://www.sciencedirect.com/science/article/pii/S037842742402071X

For atherosclerosis (hardened arteries), a review of the Yin & Yang of targeting the endocannabinoid system
Endocannabinoids and atherosclerosis: the future of therapeutic strategies—a review
https://journals.lww.com/cardioplus/fulltext/9900/endocannabinoids_and_atherosclerosis__the_future.88.aspx
“Studies have shown that CB1 receptors are pro-atherogenic while CB2 receptors exhibit anti-atherogenic properties. Activation of the ECS, especially under ischemic conditions, promotes CB1 expression and free radical production, which damages endothelial cells and accelerates the development of atherosclerosis. Inhibition of specific ECS receptors and enzymes has shown promise in reducing atherosclerosis complications, as evidenced by outcomes from major clinical trials”.

On stem cells, a review of 38 studies found CBD to protect them
Cannabidiol effects in stem cells: A systematic review
https://pubmed.ncbi.nlm.nih.gov/39653426/

A review of the post-mortem tests for synthetic cannabinoids & other new psychoactives
The State of the Art in Post-Mortem Redistribution and Stability of New Psychoactive Substances in Fatal Cases: A Review of the Literature
https://www.mdpi.com/2813-1851/3/4/33

Preclinical

In a rat model of periodontitis (gum disease), CBD combined well with taurine to decrease inflammation & bone loss
Combination of Cannabidiol with Taurine Synergistically Treated Periodontitis in Rats
https://pubmed.ncbi.nlm.nih.gov/39632669/

In a rat model of pain, the ability of dopamine to be a painkiller was mediated by the CB1 & CB2 receptors & the painkilling of anandamide was mediated by the dopamine receptor
INTERACTION BETWEEN THE DOPAMINERGIC AND ENDOCANNABINOID SYSTEMS PROMOTES PERIPHERAL ANTINOCICEPTION
https://www.sciencedirect.com/science/article/abs/pii/S0014299924008859
For more on dopamine & the ECS, see my essay ‘In Defense of Dopamine: An Endocannabinoid Story’.
Of course, if the endocannabinoids are whales, dopamine is a shark.

In a mouse model of itching, how the CB1 receptor mediated both the physical sensations & related emotions via glutamate & GABA (the brain's primary excitatory & inhibitory neurotransmitters respectively) in the prefrontal cortex
Differential regulation of pruritic sensation and emotion by cannabinoid type 1 receptors on mPFC glutamatergic and GABAergic neurons
https://www.nature.com/articles/s41401-024-01426-1

In mice, how the CB1 receptors of their eyes helped control their tears in a gendered manner
A Sex-Dependent Cannabinoid CB1 Receptor Role in Circadian Tearing of the Mouse
https://iovs.arvojournals.org/article.aspx?articleid=2802318

Novel Studies

(my new grab bag section for stuff I haven’t quite seen before)

In a rat model of depression, ketamine’s rapid antidepressant effect seemed to be mediated via the endocannabinoid system
Modulation of the endocannabinoid system by (S)-ketamine in an animal model of depression
https://www.sciencedirect.com/science/article/pii/S1043661824004900
And in a rat model of depression & epilepsy, the benefits of caloric restriction seemed to be at least partially mediated by the endocannabinoid system
Endocannabinoid involvement in beneficial effects of caloric restriction in a rodent model of comorbid depression and epilepsy
https://www.sciencedirect.com/science/article/abs/pii/S027858462400280X
Two more for our list of beneficial treatments that turn out to use the ECS to help.

A thesis project on Finnish drug slang
FINNISH DRUG SLANG AND THE INFLUENCE OF ENGLISH ON ITS FORMATION
https://jyx.jyu.fi/bitstream/handle/123456789/98788/1/URN%3ANBN%3Afi%3Ajyu-202412047607.pdf
“Some of the terms are native to Finnish, such as poltto (burning), pilvi (cloud), pajari and paja, where the original meaning is unknown. While some terms are clearly influenced by the drug slang of the United States via calques and loan words. Examples of these are kukka, kukinto, nuppu (flower); dänkki (dank); savu, sauhu (smoke); nugetti (nugget); and ruoho (grass) (See example 1.). The influence of English is also present through anglicism, for example weedi (weed) is a clear example of this. Also, abbreviations are noticeable in the terms for cannabis, such as QQ/qq, referring to the word kukka (See example 1.), and mari, the clipped version of the word marijuana. American influence shows itself also in some humorous slang terms such as jazzi tupakka (jazz cigarette).”

How THC moves through a sheep
The Pharmacokinetics of Δ9-Tetrahydrocannabinol in Sheep
https://pubmed.ncbi.nlm.nih.gov/39595380/
tl;dr: baa-dly
#papajoke

the Headlines & Fav Articles

The UN High Commissioner for Human Rights Volker Türk said the "so-called War on Drugs has failed, completely and utterly"
https://www.marijuanamoment.net/war-on-drugs-has-completely-and-utterly-failed-united-nations-human-rights-commissioner-says
#Amen

A federal judge sided for Treez, ruling that the Department of Homeland Security was wrong to deny a H-1B visa to one of the company’s workers
https://www.cannabisbusinesstimes.com/top-stories/news/15709867/judge-grants-treez-favorable-judgement-in-cannabisrelated-visa-lawsuit-against-feds

Meta shutting down lots of cannabis accounts on Instagram & Facebook
https://cannabis.net/blog/opinion/fb-and-ig-are-shutting-down-cannabis-accounts-left-and-right-the-migration-to-x-for-cannabis-br
Meta is the worst, but this article advocates for instead using X, which is the worst of the worst.

In a case of Walmart workers wanting to sue over anti-cannabis discrimination, a federal appeals court sided with Walmart despite employment discrimination against cannabis users being explicitly forbidden under state law
https://www.marijuanamoment.net/workers-cant-sue-employers-who-violate-new-jerseys-marijuana-anti-discrimination-law-federal-court-says-siding-with-walmart/

In Illinois, despite a contrary ruling in September, the Supreme Court now ruled that the smell of raw cannabis justifies a police search
https://www.marijuanamoment.net/illinois-supreme-court-rules-that-the-smell-of-marijuana-justifies-police-searches-of-vehicles
https://cannabislaw.report/illinois-supreme-court-rules-smell-of-raw-cannabis-enough-for-police-to-search-a-vehicle-smell-of-burnt-cannabis-is-not/
“The disparity, that the smell of unsmoked marijuana is justification for a warrantless search, while the smell of smoked pot is not, “defies logic,” Justice Mary O’Brien wrote in her dissent.”

In Minnesota, they will not expand their medical cannabis delivery options to include dry powder inhalation, infused flower & concentrates (which is a shame because some medical patients need easy-to-use high-THC options)
https://cannabislaw.report/press-release-minnesotas-medical-cannabis-program-will-not-expand-medication-options-in-2025/

A podcast on Magu, the little-known ancient Taoist hemp goddess
https://substack.com/home/post/p-152866639

International

In the Netherlands, coffee shops in cities participating in the new regulated cannabis program will be required to sell only regulated cannabis by April 2025
https://www.rijksoverheid.nl/actueel/nieuws/2024/12/10/experimenteerfase-van-het-experiment-gesloten-coffeeshopketen-wietexperiment-start-in-april

In the UK, the Food Standards Agency released a timeline that would see the first CBD products authorized by spring 2025 (seven years after they started the novel foods process)
https://cannabishealthnews.co.uk/2024/12/10/uks-first-authorised-cbd-products-expected-by-spring-2025/

In Japan, they increased their penalties for cannabis use up to seven years in prison but allowed for pharmaceutical cannabinoids
https://www.japantimes.co.jp/news/2024/12/12/japan/crime-legal/japan-cannabis-laws/

In Canada, a government report found that the illicit market has shrunk greatly, youth use has not increased & impaired driving is down
https://www.marijuanamoment.net/canadas-marijuana-legalization-law-effectively-shifts-people-away-from-illicit-market-while-youth-use-remains-steady-government-report-shows

The Laws, The War on Drugs & Driving

Praise be! The US’s first state-sanctioned safe consumption site to open in Providence, RI
https://www.marijuanamoment.net/the-uss-first-state-sanctioned-safe-drug-consumption-site-prepares-to-open-in-rhode-island

A new report on Russia’s rise of darknet markets & dead drops revolutionizing drug deliveries as well as the involvement of organized crime in the drug trade
https://globalinitiative.net/analysis/russia-drug-trade-organized-crime/

For driving, on the perceived impairment from the use of cannabis, alcohol or co-use
Event-level influences of alcohol, cannabis, and simultaneous use on perceived driving risk
https://pubmed.ncbi.nlm.nih.gov/39636599/

Business & Education

Jazz Pharmaceuticals released new positive data on CBD at the American Epilepsy Society 2024 meeting
https://www.cannabisbusinesstimes.com/industry-headlines/news/15710052/jazz-pharmaceuticals-showcases-evidence-reinforcing-epidiolex-cbd-medical-benefits
https://www.prnewswire.com/news-releases/jazz-pharmaceuticals-to-showcase-new-real-world-evidence-reinforcing-epidiolex-cannabidiol-benefits-and-broad-spectrum-efficacy-in-treatment-resistant-epilepsies-at-the-american-epilepsy-society-2024-annual-meeting-302324979.html

Psychedelics, Plant Medicines & Other Psychoactives

On tripping CEOs & the rise of psychedelic for business leaders
https://www.nytimes.com/2024/12/12/business/psychedelic-retreats-ceos.html
Ha. “In a world powered by ego, though, some business people suggest that the growing popularity of ego-checking drugs could have worrisome professional fallout. That concern was summed up in a recent viral post on X, from the chief executive of an artificial intelligence company, who wrote: “Of the Silicon Valley founders I know who went on some of the psychedelic self-discovery trips, almost 100% quit their jobs as CEO.””
Not many people know, but I was once the high-flying CEO of Lex, Inc. (motto: we also walk dogs). But after a mountaintop experience, I decided to dedicate myself to psychoactives as the high-flying founder of White Whale Creations. I even fly economy now. Thanks magic mushrooms!
(PS: if you get the reference of that motto without looking it up, I’ll send you a free copy of one of my books)

On a new music-centered ketamine therapy reported on by the tireless Michelle Lhooq
https://ravenewworld.substack.com/p/ketamine-therapy-is-getting-groovier

In Muslims using psychedelics, two hard cases that involve experiences with jinns (spiritual entities of the Islamic world)
https://www.ecstaticintegration.org/p/jinns-trips-and-spiritual-psychosis

The Psychoactive Research

For psychedelics causing psychosis, a meta-analysis of human studies suggests schizophrenia might not be a definite exclusion criteria for clinical trials
Reconsidering evidence for psychedelic-induced psychosis: an overview of reviews, a systematic review, and meta-analysis of human studies
https://pubmed.ncbi.nlm.nih.gov/39592825/
And a case series of psychosis from psilocybin
The many faces of psilocybin-related psychosis: A case series
https://www.sciencedirect.com/science/article/pii/S2773021224000397

For the depression of bipolar II disorder, four people who used psilocybin for anti-depressant effects
Psilocybin-Assisted Psychotherapy for Treatment-Resistant Depression in Bipolar II Disorder
https://www.liebertpub.com/doi/10.1089/psymed.2024.0032

On how the subjective effects of ketamine & psilocybin correlate to therapeutic outcomes
Meta-correlation of the effect of ketamine and psilocybin induced subjective effects on therapeutic outcome
https://pubmed.ncbi.nlm.nih.gov/39369173/

On how psychedelics may help with borderline personality disorder
Theorizing that Psychedelic Assisted Therapy May Play a Role in the Treatment of Trauma-Induced Personality Disorders
https://pubmed.ncbi.nlm.nih.gov/39634920/

The pharmacology of mescaline
Safety pharmacology of acute mescaline administration in healthy participants
https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bcp.16349

For kratom, a review of the cognitive effects
Exploring the cognitive effects of kratom: A review
https://www.sciencedirect.com/science/article/pii/S0166432824005436

A review of the psychological interventions used with psychedelic treatments
Quality of reporting on psychological interventions in psychedelic treatments: a systematic review
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(24)00333-X/abstract

A review of the two buzziest words of the decade: artificial intelligence & psychedelic medicine
Artificial intelligence and psychedelic medicine
https://pubmed.ncbi.nlm.nih.gov/39308441/

The Plant & the History

On the evidence of hemp use during the Warring States period of Chinese history
Agricultural development in southern Shandong, northern China, from the Warring States to the Han dynasty: New archaeobotanical evidence from the site of the ancient capital city of Zhu State
https://www.sciencedirect.com/science/article/abs/pii/S2352226724000849
There’s a reason China long called itself the Land of Mulberry & Hemp.

Growing, Processing & Measuring

On the effects of the red:far-red light ratio on cannabinoid yield
Decreasing R:FR ratio in a grow light spectrum increases inflorescence yield but decreases plant specialized metabolite concentrations in Cannabis sativa
https://www.sciencedirect.com/science/article/pii/S0098847224004179

On the effects of nutrients & planting density on yield
Cannabis yield and cannabinoid profile affected by plant nutrition and planting density
https://www.sciencedirect.com/science/article/pii/S0926669024022702

For hemp seed production, an analysis of row distance & the use of the Secuieni method
Research Regarding the Influence of Some Technological Factors on the Productivity of Some Monoecious Hemp Varieties Cultivated at Agricultural Research and Development Station Secuieni in Romania
https://www.mdpi.com/2073-4395/14/12/2946

On using bioreactors to produce hemp roots for traditional Chinese medicine
In vitro adventitious roots of hemp in bioreactor culture to efficiently produce non-cannabinoids and cannabidiol phytochemicals
https://link.springer.com/article/10.1007/s11240-024-02922-2

A thesis project on the effects of light integrals on yield
Responses of Medical Cannabis to Daily Light Integrals Higher Than Summer Sunlight: Yield, Morphology, And Quality
https://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=1379&context=etd2023

A thesis project on greenhouse cannabis growing
Meeting the Challenges of Greenhouse Production and Propagation of Cannabis sativa
https://etd.auburn.edu/handle/10415/9572

For extraction, a review of the various techniques
Cannabis sativa: Extraction Methods for Phytocannabinoids -An Update
https://www.researchgate.net/publication/386551712_Cannabis_sativa_Extraction_Methods_for_Phytocannabinoids_-An_Update

Analyzing the cannabis of Ecuador
Chemical Characterization and Analysis of Microbiological Constituents, Heavy Metals, and Pesticides in Non-Psychoactive Cannabis (Cannabis sativa L.) Inflorescences and Extracts from Ecuador
https://www.preprints.org/manuscript/202412.0287/v1

On growing hemp in Uzbekistan
MORPHOLOGICAL FEATURES OF INDUSTRIAL HEMP CULTIVATION IN SOIL AND CLIMATIC CONDITIONS OF SYRDARYA REGION
https://webofjournals.com/index.php/8/article/view/2397/2373

Genomic elements in wild type & domesticated cannabis
Cannabis sativa L. Miniature Inverted Repeat Elements Landscapes in Wild-Type and Domesticated Genomes
https://www.preprints.org/manuscript/202412.0528/v1

Measuring terpene levels with GC×GC-MS
Sorbent-Based Sampling With Two-Stage Trapping/Desorption Coupled to Comprehensive Two-Dimensional Gas Chromatography and Mass Spectrometry for Terpenoids Profiling in Cannabis
https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/ansa.202400044

Creating electrochemical sensors for measuring THC levels
Electrochemical sensors for fast classification of different Cannabis sativa L. samples according to total Δ9-tetrahydrocannabinol content
https://pubmed.ncbi.nlm.nih.gov/39366244/

Analysis of the aquaphotomics (water matrix structures) of fresh cannabis buds
Aquaphotomics study of fresh cannabis inflorescence: near infrared spectral analysis of water matrix structures
https://link.springer.com/article/10.1007/s00216-024-05685-z

Food & Nutrition

On consumer preferences around cannabinoid-infused beverages
Canning cannabis: Consumer preferences for CBD- and THC-infused beverages
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/4343A6856F99D7C186836D32ADBD810A/S193143612400021Xa.pdf/div-class-title-canning-cannabis-consumer-preferences-for-cbd-and-thc-infused-beverages-div.pdf

A genomic study of the dry matter content of hemp seeds
Dry matter content variation in seeds of hemp for fiber - Comparative study in some genotypes
https://jhfb.ro/index.php/jhfb/article/view/51

A thesis project on a hemp milk ice cream
Development of a novel ice cream with hemp milk based on chia seed mucilage as a stabilizer
https://mro.massey.ac.nz/server/api/core/bitstreams/801ea2ba-faa0-4896-a76d-425e73c2d4de/content

On the best way to roast hemp seeds
Development of hemp seed (Cannabis sativa L.) beverages: Roasting effects and safety
https://akjournals.com/view/journals/066/aop/article-10.1556-066.2024.00147/article-10.1556-066.2024.00147.xml
Or just put them in a room with Lisa Lampanelli, Gilbert Gottfried & Sarah Silverman.
#papajoke
(My 3-year-old has vetoed any papa jokes related to her. Luckily, it still makes both kids laugh to constantly hint that we’re about to leave for the dentist…)

Industrial Uses & Fiber

Europe’s evolving regulatory landscape around hemp fiber
Industrial Applications of Hemp Fiber in Europe and Evolving Regulatory Landscape
https://www.tandfonline.com/doi/pdf/10.1080/15440478.2024.2435047

On using hemp to remove forever chemicals from soil to help the bees
Phytoremediation evaluation of forever chemicals using hemp (Cannabis sativa L.): Pollen bioaccumulation and the risk to bees
https://pubmed.ncbi.nlm.nih.gov/39638132/

Thermal insulation with hemp straws
Thermal insulation performance of composite materials using industrial hemp straws
https://link.springer.com/article/10.1007/s00231-024-03522-8

A review of hempcrete as a sustainable construction practice
Mainstreaming precast and block hempcrete—a carbon sequestering solution for the built environment
https://www.academia.edu/2997-2027/1/4/10.20935/AcadMatSci7369

CANNABINOID SCIENCE

A Brazilian review on the clinical use of CBD
Research and Clinical Practice Involving the Use of Cannabis Products, with Emphasis on Cannabidiol: A Narrative Review
https://www.mdpi.com/1424-8247/17/12/1644

A review on the many applications of CBD
Cannabidiol (CBD) as an emerging nutraceutical ingredient from industrial hemp: regulation, production, extraction, nutraceutical properties, and functionality
https://www.tandfonline.com/doi/full/10.1080/10408398.2024.2436130

Public Health

For medical cannabis contamination, a social media analysis centered on the Florida medical cannabis program
Patients’ Perceptions of Cannabis Contamination in Florida's Medical Program
https://karger.com/mca/article-pdf/doi/10.1159/000542929/4311290/000542929.pdf
“Key results were: 1. Multiple mentions of possible contamination for products from medical cannabis dispensaries reported by Florida program patients. 2. Patients sought second opinions when concerned about possible contamination and shared personal experiences as well as advice on what concerned patients should do if they believe they have contaminated products. 3. Some patients expressed feelings of anxiety and worry about health, safety, and quality control, while others that described possible product contamination did not express concern. 4. Patients wanted changes regarding vertical integration, company accountability, state oversight, and home grow law.”

In Washington state after legalization, an analysis of how people use cannabis & alcohol
Does cannabis substitute or complement alcohol after recreational cannabis legalization in the Washington State? A three-level mixed-effects modeling
https://www.sciencedirect.com/science/article/abs/pii/S0306460324002673

In public health data, people who purchase from the black market are more likely to be on parole but less likely to report that they have committed a crime
A Tale of Two Groups: Criminal Activity Among Cannabis Dispensary Purchasers and Non-Dispensary Purchasers
https://journals.sagepub.com/doi/abs/10.1177/00111287241305044

In Malta, a thesis project on the opinions of pharmacists on the rollout of CBD products
Cannabidiol and the pharmaceutical industry
https://www.um.edu.mt/library/oar/handle/123456789/129527

In Chile, validation of a scale on people's belief about the capacity to resist cannabis
Psychometric properties and invariance testing of the Cannabis Refusal Self-Efficacy Scale in a Chilean sample
https://www.tandfonline.com/doi/abs/10.1080/00952990.2024.2411681
On a scale of 0 to 14, I got a negative 3.

In Indonesia, on the possibility of legalizing medical cannabis
Legalization of Marijuana in the Medical Sector: A Criminal Law Perspective
https://journal.pubmedia.id/index.php/lawjustice/article/view/3352

Adolescents & Young Adults

A review of the safety of cannabis use by adolescents
Adolescent Cannabis Use: It’s Safe Right?
https://link.springer.com/article/10.1007/s40501-024-00337-6

An analysis of the effects on pro- & anti-cannabis messaging on young adult cannabis use
How are pro- and anti-cannabis messaging exposures related to US young adult cannabis use-related factors?
https://academic.oup.com/her/advance-article-abstract/doi/10.1093/her/cyae038/7920469?redirectedFrom=fulltext

In college women, the effects of alcohol & cannabis use on sexual aggression bystander intervention
Event-level effects of alcohol, cannabis, and simultaneous alcohol and cannabis use on bystander intentions in response to hypothetical situations among college women
https://www.sciencedirect.com/science/article/abs/pii/S0306460324002764

In young female adults who binge eat, cannabis use was associated with more binge eating independent of depressive symptoms
Cannabis Use and Binge Eating among Young Adults: The Role of Depressive Symptoms
https://www.sciencedirect.com/science/article/abs/pii/S0022395624007179

On the effects of racial teasing on adolescent cannabis & nicotine vaping
Effects of racial teasing on adolescent marijuana use and nicotine vaping: An analysis of the Virginia Youth Risk Behavior Surveillance System
https://pubmed.ncbi.nlm.nih.gov/39383559/

On detecting psychosis in adolescent daily cannabis users with a Rorschach test
Detection of Psychosis by Rorschach Performance Assessment System Variables in Adolescents With Chronic Daily Cannabis Use
https://connect.springerpub.com/content/sgrehpp/early/2024/12/04/ehpp-2024-0005.abstract

In young adults with social anxiety, they had higher levels of cannabis use & problems via coping motives
Negative urgency increases risk for coping-motivated cannabis outcomes in socially anxious male emerging adult cannabis users
https://www.tandfonline.com/doi/abs/10.1080/07448481.2024.2435936
Word. In college, parties gave me sometimes intense social anxiety, so I used cannabis, which made it worse. But I couldn’t help myself. And now, 20 years later, I’m still working on my coping motives.

How family history moderated the predictors of youth alcohol & cannabis initiation
Social and Environmental Predictors of Youth Alcohol and Cannabis Initiation Risk: The Moderating Role of Family History of Substance Use Disorders
https://www.tandfonline.com/doi/abs/10.1080/10826084.2024.2434007

In young adults, on their feelings of the co-use of cannabis & alcohol
Within-episode relations among simultaneous alcohol and cannabis use and continued drinking: The role of momentary subjective responses, craving, and drinking context
https://pubmed.ncbi.nlm.nih.gov/39367536/

In European adolescents, more problematic cannabis use was associated with a lower socioeconomic background
Unequal cannabis use among European adolescents: the mediating role of perceived access and risk
https://run.unl.pt/bitstream/10362/176000/1/Perelman_2024_EJPH_34_Sup3_iii364.pdf

On the psychosocial factors of youth vaping nicotine and/or cannabis
Nicotine and cannabis vaping among early high school adolescents: Disparities of use across sociodemographic characteristics and associations with psychosocial factors
https://www.sciencedirect.com/science/article/pii/S2352853224000543

A questionnaire for adolescents on the expected effects of cannabis across different races
Measurement equivalence of the Marijuana Effect Expectancies Questionnaire-Brief across sex, race/ethnicity, and their co-occurring social identities for Black, Latinx, and non-Latinx white youth in the Adolescent Brain Cognitive Development (ABCD) Study
https://www.jsad.com/doi/abs/10.15288/jsad.24-00201

In a mouse model of adolescent THC exposure, later in their life, they had stronger neural responses to opioids
Neural basis of adolescent THC-induced potentiation of opioid responses later in life
https://www.nature.com/articles/s41386-024-02033-8

The Brain & Neurological Disorders

In epilepsy, a review of the role of the endocannabinoid system in its pathogenesis & treatment
The role of the endocannabinoid system in the pathogenesis and treatment of epilepsy
https://www.degruyter.com/document/doi/10.1515/revneuro-2024-0114/html

For Alzheimer's disease, a computer analysis of new FAAH inhibitors for treatment
Discovery of novel fatty acid amide hydrolase (FAAH) inhibitors as anti-alzheimer agents via in-silico-based drug design, virtual screening, molecular docking, molecular dynamics simulation, DFT, and non-clinical studies
https://www.sciencedirect.com/science/article/abs/pii/S0091305724002375

Mental Health, Addiction & Cannabis Use Disorder

A survey found that people who use CBD had higher levels of depression & anxiety
Mental health and cannabidiol: an initial test
https://www.tandfonline.com/doi/abs/10.1080/14659891.2024.2428726
However, the effect size was small & the obvious explanation is that they are using CBD to help their depression & anxiety. I know that I certainly do.

On sleep, a book chapter on the role of anandamide in the sleep-wake cycle
The role of anandamide in the sleepewake cycle
https://www.researchgate.net/publication/386506594_The_role_of_anandamide_in_the_sleepewake_cycle_12

For people seeking help around their cannabis use, a survey of their characteristics
Help-Seeking Behaviours Among Cannabis Consumers in Canada and the United States: Findings from the International Cannabis Policy Study
https://www.sciencedirect.com/science/article/pii/S2772724624000908

On developing a digital intervention for depression & cannabis use by including individuals with lived experiences
Inclusion of Individuals With Lived Experiences in the Development of a Digital Intervention for Co-Occurring Depression and Cannabis Use: Mixed Methods Investigation
https://pubmed.ncbi.nlm.nih.gov/39374076/

A thesis project on Pavlovian processes regulated via the endocannabinoid system & the effects of gender
Examining Behavioral Flexibility in Pavlovian Processes Through the Lens of Endocannabinoid Regulation and Sex Differences
https://www.proquest.com/openview/b3aa5739a017d227238162b1335e240e/1

On CBN & insomnia, a thesis project of EEG scans of people using CBN for sleep (which unfortunately is not accessible)
Electroencephalographic Findings in Insomnia Disorder: Treatment Effects Under Cannabinoid Interventions
https://ses.library.usyd.edu.au/handle/2123/33425

In a rat model of anxiety, cannabis extract increased anxiety in a maze
Chronic Cannabis Extract Modulates Anxiety Behavior in Wistar Rats: VTA Histology and Catecholamine Analysis
https://www.researchgate.net/publication/386363736_International_Journal_of_Pharmaceutical_and_Bio-Medical_Science_Chronic_Cannabis_Extract_Modulates_Anxiety_Behavior_in_Wistar_Rats_VTA_Histology_and_Catecholamine_Analysis

Pain, Musculoskeletal & Surgeries

In a rat model of femoral head osteonecrosis (painful loss of blood flow to the head of the hip), blocking the MAGL enzyme (which raises levels of 2-AG) restored bone homeostasis via the phosphoinositide 3-kinases (PI3K)/ the serine/threonine kinase (AKT)/ (glycogen synthase kinase-3 beta) GSK3β pathway
MAGL blockade alleviates steroid-induced femoral head osteonecrosis by reprogramming BMSC fate in rat
https://pubmed.ncbi.nlm.nih.gov/39368012/

In mice with skeletal muscle injury, blocking the CB1 receptor improved muscle regeneration, improved their inflammation profile & increased endocannabinoid levels
The CB1 antagonist Rimonabant improves muscle regeneration and remodels the inflammatory and endocannabinoid profile upon injury in male mice
https://www.sciencedirect.com/science/article/abs/pii/S0024320524008865

In a rat model of neuropathic pain, activating the CB2 receptor lowered pain & lessened the development of morphine tolerance
The cannabinoid CB2 agonist LY2828360 suppresses neuropathic pain behavior and attenuates morphine tolerance and conditioned place preference in rats
https://www.sciencedirect.com/science/article/abs/pii/S002839082400426X

In the freshwater fish Brycon amazonicus, activating the CB2 receptor promoted protection against oxidative stress
Activation of cannabinoid type 2 (CB2) receptors promotes the maintenance of redox homeostasis and protects against oxidative distress in the Neotropical freshwater fish matrinxã Brycon amazonicus (Characiformes: Bryconidae)
https://www.ni.bio.br/content/v22n4/1982-0224-2024-0065/1982-0224-ni-22-04-e240065.pdf

Guts, Metabolism & Oral Health

In people with inflammatory bowel disease, their guts had lower levels of CB1 & CB2 receptors & higher levels of several endocannabinoids
Modulation of CB1 and CB2 receptors and endocannabinoid activity in inflammatory bowel diseases
https://pubmed.ncbi.nlm.nih.gov/39652903/

For pancreatitis, a review of the mysterious role of cannabis in disease progression (nice charts)
The Underrecognized Role of Cannabis in the Etiology of Acute Pancreatitis
https://pubmed.ncbi.nlm.nih.gov/39371741/

In rabbits, how CBD altered their digestive system
Cannabidiol can affect morphology, morphometry, enzymatic and microbial activity of rabbit digestive system
https://academic.oup.com/jas/advance-article-abstract/doi/10.1093/jas/skae376/7921144?redirectedFrom=fulltext

Immune System & Microbial

In people living with HIV, the majority used non-medical cannabis & those with poorer physical health were more likely to be using it
Correlates of Using Medically-Authorized Cannabis in a Large Cohort of People Living with HIV Who Use Cannabis
https://link.springer.com/article/10.1007/s10461-024-04568-9

In a mouse model of inflammation, anandamide blocked chronic inflammation via the T cells of the immune system
The endocannabinoid anandamide prevents TH17 programming of activated T lymphocytes while preserving TH1 responses
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1528759/abstract

In a mouse model of the fungal infection Candida albicans, the CB2 receptor played an immunomodulatory role in inflammation more strongly in males than females
INVESTIGATING THE EFFECT OF SEX AND CB2R ON NEUTROPHIL EGRESSION AND MATURITY PHENOTYPE IN MICE WITH A SYSTEMIC CANDIDA ALBICANS INFECTION
https://scholarworks.calstate.edu/downloads/zw12zf88s

Reproduction & Hormones

In pregnant mice, a thesis project on the effects of maternal THC exposure during the period of rapid placental growth
THE EFFECTS OF MATERNAL EXPOSURE TO DELTA-9-TETRAHYDROCANNABINOL DURING THE PERIOD OF RAPID PLACENTAL GROWTH IN SWISS WEBSTER MICE
https://scholarworks.calstate.edu/downloads/jm215005c

The Heart

For cardiometabolic risk factors, people with higher blood levels of endocannabinoids were associated with worse liver, kidney, gonadal & adipose (fat) health
Higher plasma levels of endocannabinoids and analogues are correlated with a worse cardiometabolic profile in middle-aged adults
https://link.springer.com/article/10.1007/s13105-024-01063-6

The Lungs

In Thailand, cannabis usage not linked to increased tuberculosis admissions to the hospital
Relationship between hospitalization from cannabis usage and pulmonary tuberculosis in Thailand from 2017 to 2022
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0312139

In various lung cells, CBD & its metabolites bound to CB2 receptors
Metabolism of Cannabidiol in Respiratory Associated Cells and HepG2- derived cells and Molecular Docking of Cannabidiol and its Metabolites with CYP Enzymes and Cannabinoid-2 Receptor
https://assets-eu.researchsquare.com/files/rs-5432858/v1/aed84ce3-1523-4f98-a2e2-adf6dd009c24.pdf?c=1733732185

The Skin

On the potential of CBD for burn care
The Potential Role of Cannabidiol (CBD) in Burn Care: Evidence and Future Directions
https://pubmed.ncbi.nlm.nih.gov/39382370/

Cancer & Chemotherapy

A metabolic study of how cannabis extracts lowered proliferation
Integration of transcriptome and metabolome provides insights into metabolites and pathways associated with antiproliferative activity of cannabis flower extracts
https://www.sciencedirect.com/science/article/pii/S0926669024022167

In ovarian cancer cells, CBD inhibited proliferation via the CB1 receptor, regulation of fatty acid uptake & stress to the endoplasmic reticulum (cellular center of protein folding & processing)
Cannabidiol attenuates lipid metabolism and induces CB1 receptor-mediated ER stress associated apoptosis in ovarian cancer cells
https://www.researchsquare.com/article/rs-5359456/v1

In Ewing’s sarcoma (an aggressive pediatric bone cancer), this thesis project showed CBD altered protein levels related to migration
The Effects of Cannabinoids on Migration-Related Protein Expression in Ewing’s Sarcoma
https://digitalcommons.jsu.edu/cgi/viewcontent.cgi?article=1081&context=etds_theses

In leukemia cells, the endocannabinoid N-arachidonoyl dopamine (NADA) helped to overcome resistance to the drug venetoclax
The Endocannabinoid N-Arachidonoyl Dopamine Induces Leukemia Cell Pyroptosis to Overcome the Venetoclax Resistance
https://www.sciencedirect.com/science/article/pii/S000649712404953X

Synthetic Cannabinoids & Hemp-Derived Cannabinoids

On the toxicity of two old synthetic cannabinoids: JWH-018 & JWH-019
Unveiling the toxicity of JWH-018 and JWH-019: Insights from behavioral and molecular studies in vivo and vitro
https://www.sciencedirect.com/science/article/pii/S0147651324015768

In pigs, a toxicity study of cumyl-5F-P7AICA & whether adding a carboxamide altered the toxicity
Does a carboxamide moiety alter the toxicokinetics of synthetic cannabinoids? A study after pulmonary and intravenous administration of cumyl-5F-P7AICA to pigs
https://link.springer.com/article/10.1007/s00204-024-03906-z

Biochemical Discoveries

The various variants of CB1 receptors seem to have similar binding selectivity for anandamide & 2-AG
No Evidence for Endocannabinoid-Induced G Protein Subtype Selectivity at Human and Rodent Cannabinoid CB1 Receptors
https://pubmed.ncbi.nlm.nih.gov/39373143/

A computer analysis of how cannabinoids bind at the 5-HT1A serotonin receptor
EVALUATION OF THE BINDING MODE OF CANNABINOID DERIVATIVES AT THE 5-HT1A RECEPTOR THROUGH in silico APPROACHES
https://electronicconferencegppharmacy.uff.br/wp-content/uploads/sites/463/2024/11/Desenvolvimento-16.pdf

In roundworms, the fatty acid juniperonic acid shared similar binding interactions as endocannabinoids
Juniperonic Acid Biosynthesis is Essential in Caenorhabditis Elegans Lacking Δ6 Desaturase (fat-3) and Generates New ω-3 Endocannabinoids
https://pubmed.ncbi.nlm.nih.gov/32961767/

Cool Chemistry & Tools

Microencapsulation to improve delivery of CBDA as an antimicrobial & antioxidant
Alginate-based microencapsulation as a strategy to improve the therapeutic potential of cannabidiolic acid
https://www.sciencedirect.com/science/article/abs/pii/S0378517324013103

A lipid carrier for nano-CBD
CBD-Loaded Nanostructured Lipid Carriers: Optimization, Characterization, and Stability
https://pubmed.ncbi.nlm.nih.gov/39372028/

Designing a nano-CBD aerosol for inhalation
Design and Bottom-up Production of an Aerosolizable Cannabidiol Nanosuspension
https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.4c01095

On testing for THC metabolites in fingernails with a LC-MS/MS
LC-MS/MS Analysis of 11-nor-9-carboxy-tetrahydrocannabinol in Fingernails
https://www.earticle.net/Article/A458417

On using voltammetric analysis for measuring cannabinoid levels
APPLICATION OF VOLTAMMETRIC METHODS IN ELECTROCHEMICAL ANALYSIS OF CANNABINOIDS
https://eprints.ugd.edu.mk/35193/2/POSTER_27SCTM_MA_2024%20vm-final%20ver.pdf

A thesis project on photoactive CB1 agonists
Selective Ligands with Photochromic Affinity Switches for the Human Cannabinoid Receptor Type 1: Synthesis, Characterization, and Biological Evaluation
https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/frontdoor/deliver/index/docId/38767/file/Rodriguez-Soacha_Diego_Thesis.pdf

Thanks.
- lex

PS: For this week’s chanteuse, the album ‘One Life to Live’ by Phyllis Dillon. The beloved singer of early reggae, this album includes Dillon’s originals as well as some lovely covers (I dig her versions of ‘Love the One You’re With’ & the Beatle’s ‘Something’). After growing up as a singer in rural Jamaica, she wrote her first hit, ‘Don’t Stay Away’ in 1966, a recording that has been described as "perhaps the finest female performance in Jamaican music”. With a string of hits & performances across the island, Dillon became “the Queen of Rocksteady” (rocksteady was a successor of ska with a slower beat & a precursor to reggae, named for the Alton Ellis song ‘Rocksteady’ which was originally written by Dillon as ‘It’s Rocking Time’). However, despite all of her work, she wasn’t making any money. She finally got sick of it & moved to New York City & started to raise her family. She used the vacation time from her bank job to go back to Jamaica to record more or to fly to London for shows, but she mostly concentrated on her family. In the ‘90s, she began a successful comeback career with dates across Germany, the UK & Japan but a diagnosis of breast cancer cut short this revitalization & she passed at the age of 59. Posthumously, Jamaica awarded Phyllis Dillon the Order of Distinction.

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Cannabinoids & the People