C&P#157: (my first EmJay!) orgasms, complex regional pain & skin blistering

France going medical + Thai "Cannabis King" is new PM

Sep 15, 2025

Cannabis for female orgasmic difficulty + complex regional pain syndrome + epidermolysis bullosa (skin blistering disease)
CBD topical for TMJ facial pain
Cannabis use disorder linked to 3x risk of oral cancer + cannabis use linked to asthma & chronic obstructive pulmonary disease
4x on HIV: goods & bads
Trichomes are bigger these days!
Preclinical: CBD for methamphetamine use disorder + obesity + schizophrenia + arthritis + Parkinson’s
A CBD surgical mesh for hernia repairs & less infections
Paracetamol & acetaminophen both work via the endocannabinoid system
An AI for medical cannabis therapy
In food: endocannabinoids in cheese, hemp for brewing, hemp oil in a gluten-free bakery, hemp seeds in chutneys & hemp proteins in choux pastries
“Overdoses should be termed “Prohibition-Related Deaths”” (Amen!)

(this week’s numbers: ~8k words, ~21 minutes reading time, 189 papers)

Hello everyone,
Welcome to the 157^th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news & coverage of psychedelics, the War on Drugs & harm reduction. Support this work sharing canna-science with a paid subscription here. As always, ask me anything.
#FreePalestine

📌 Editor’s notes:
My first EmJay nomination! It’s a cannabis industry award & I’m up for Cannabis Journalist of the Year with a bunch of other great nominees (and old buddies like Jimmy Young). If you'd like to vote for me, the journalism category is all the way at the bottom of the main voting page or this link to vote for me directly.
And you're allowed to vote once a day, so feel free to stuff that ballot box in exchange for annotations of ~150 new canna-science papers each week. And thanks to everyone who nominated me!

Also, while you're voting, I'd recommend...
For Advocacy Organization of the Year, Realm of Caring Foundation (Sasha Kalcheff-Korn & Jan Morton)
For CBD/Hemp Brand of the Year, EntheaCare (& Megan Mbengue, MSMCT, BSN, RN)

Lastly, this newsletter will be off next week while I’m at CB Expo. Let me know if I’ll see you there.
Also, is anyone else going to Cannafest Prague Trade Show & Calyx Cup? I’ve never been & was thinking that this might be the year.

🤝 Sponsor 🤝: The Cannabis & Health Research Initiative

Want to help expand the knowledge of medical cannabis use in the real world & get paid 100 bucks to do so?

Johns Hopkins University, with support from Realm of Caring, is spearheading the groundbreaking National Cannabis Study to evaluate the benefits, risks & overall outcomes of using cannabis for conditions like pain, insomnia, anxiety & more. If you are an adult in the U.S. considering starting cannabis for health reasons, this is your chance to help shape the future of cannabis research — and get compensated for your time ($100!). Join now to share your experience & contribute valuable data that could revolutionize healthcare for many patients nationwide. To learn more & sign up, visit:
https://ncs.cannabisandhealth.org/

Follow along on Instagram to keep on learning or sign up for the monthly CHRI email (curated by me) to get just the best of clinical research & new reviews each month.

🧰 Free resources 🧰

CVResearch.info: the extensive cannabinoid science archive I maintain for CV Sciences
Canna-edu videos: on YouTube @CVScienceInc & on TikTok @pluscbd (backup account @cannabinoidsandthepeople)
My Free How-To Guides on cannabinoids for different conditions. #AMA
My canna-science journalism
My glossary of cannabinoid terms (& my Neural Ocean metaphor)

And as always, at the bottom is the album of the week: Ralke’s bongos!

💖 Ways to support this work 💖
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🐋 For more from Lex… 🐋 | my Linktree |

‘Anandamide; or, the Cannabinoid’: my cannabis graphic novel series (based on Moby Dick):
- ‘SUNset’: Queer canna-history from the AIDS crisis
- ‘The CROWN’: the hunt for the chemical structure of CBN, the first fully-solved cannabinoid, as explained through elephants
First 2 seasons of my podcast ‘The Lex Files’ on cannabinoids, psychedelics & spirituality
Work with my company White Whale Creations to produce cannabis content: writing, science archives, social media, newsletters & podcasts: my portfolio

📣 A request to spread the word 📣
This newsletter only spreads by word of mouth,
so please forward to colleagues & tell your friends & relatives.

Canna-Edu Vids for CV Sciences:

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🍃 BEST OF CANNABINOID SCIENCE 🍃

(most of the phytocannabinoid data is here & the ECS data is in the ‘Canna-Science Archive’ at the bottom)

⚕️ Clinical ⚕️

For complex regional pain syndrome, the UK Medical Cannabis Registry found the initiation of medical cannabis to be associated with reduced pain levels as well as improvements in anxiety, sleep quality & general health-related quality of life
UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Complex Regional Pain Syndrome
https://onlinelibrary.wiley.com/doi/pdf/10.1002/brb3.70823

In people with chronic pain, a full-spectrum cannabis extract reduced pain, anxiety, insomnia as well as the lowered or discontinued the use of other painkillers & anti-inflammatory drugs
Effectiveness of Full Spectrum Cannabis Extracts in the Treatment of Chronic Pain: An Open Label Study
https://www.tandfonline.com/doi/full/10.1080/15360288.2025.2517778

In French people with Parkinson's disease, a survey found CBD very effective for sleep disorders, pain & rigidity/cramps
Patterns of Use and Patient-Reported Effects of Cannabinoids in People With PD: A Nationwide Survey
https://pubmed.ncbi.nlm.nih.gov/40470397/

In people with temporomandibular disorders, a CBD topical improved pain, sleep, muscle tension & migraine scores
Expanding the Therapeutic Profile of Topical Cannabidiol in Temporomandibular Disorders: Effects on Sleep Quality and Migraine Disability in Patients with Bruxism-Associated Muscle Pain
https://www.mdpi.com/1424-8247/18/7/1064

For epidermolysis bullosa (a rare genetic skin blistering disease), a survey found some reported pain & itch relief from cannabinoids & the majority reported increased well-being, with the ingestion methods being inhalation, topicals & oral
64760 Cannabinoids for Epidermolysis Bullosa Symptom Management: A Survey
https://www.jaad.org/article/S0190-9622(25)00838-2/abstract

In people with endometriosis, a survey found they used it most for pain control & the bothersome side effects of other medications, with their primary source being the black market
'In the weeds': navigating the complex concerns, challenges and choices associated with medicinal cannabis consumption for endometriosis
https://pubmed.ncbi.nlm.nih.gov/40445778/

In people with rare seizure disorders, this cohort study found CBD reduced seizures, with some becoming seizure-free
Use of cannabidiol for off-label treatment of patients with refractory focal, genetic generalised and other epilepsies
https://neurolrespract.biomedcentral.com/articles/10.1186/s42466-025-00408-w

In pain & anxiety patients, they substituted cannabis for some or all of their prescription medications
Beyond substitution: How medical cannabis patients manage health with cannabis and prescription medications
https://apha.confex.com/apha/2025/meetingapi.cgi/Paper/577146?filename=2025_Abstract577146.pdf&template=Word

In people with chronic pain, the combination of PEA & Equisetum arvense (field horsetail) caused a significant reduction in pain intensity & improvements to quality of life
Evaluation of the Clinical Efficacy of a Novel Palmitoylethanolamide–Equisetum arvense Supplement for the Management of Chronic Pain: Findings from a Prospective Clinical Trial
https://www.mdpi.com/2076-3271/13/3/169

In the traditional Thai Suk-SaiYasna remedy (containing cannabis), it reduced stress-induced cognitive impairment via Keap1-Nrf2 pathway (cellular defense mechanism of antioxidant & detoxification genes)
Suk-SaiYasna Remedy, a Traditional Thai Medicine, Mitigates Stress-Induced Cognitive Impairment via Keap1-Nrf2 Pathway
https://pubmed.ncbi.nlm.nih.gov/40508195/

In sensitive skin, a thesis project found no significant effects on water loss or redness
Assessing the efficacy of treatment protocols with Cannabis sativa L. in individuals with sensitive skin
https://repozitorij.mefst.unist.hr/en/islandora/object/mefst:2693

In dogs having orthopedic surgery, a 20:1 CBD:THC extract did not have a great effect on pain levels or limb function
Efficacy of a 20:1 CBD:THC Cannabis Herbal Extract for Pain and Inflammation in Dogs Following Tibial Plateau Levelling Osteotomy
https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2025.1676779/abstract

In a cat fear test (simulated thunderstorms), CBD decreased undesirable urinations (there’s an ‘expression of concern’ on this because of the research on animals)
Possible Anxiolytic Effects of Cannabidiol (CBD) Administration on Feline Responses to a Fear Response Test
https://pubmed.ncbi.nlm.nih.gov/40509107/

🎗️ HIV 🎗️

In people taking HIV antiretroviral therapy, adding cannabinoids increased their serotonin, β-hydroxybutyrate & Ahr signaling while reducing bile acids & acylcholines (signs of lower inflammation & less metabolic dysfunction)
Supplementing HIV-ART with cannabinoids increases serotonin, BHB, and Ahr signaling while reducing secondary bile acids and acylcholines
https://www.science.org/doi/pdf/10.1126/sciadv.adw4021

For people with HIV, heavy cannabis use was linked to a modest risk of neurocognitive decline
Joint effects of human immunodeficiency virus (HIV) and cannabis on neurocognition
https://psycnet.apa.org/record/2026-42405-001

In a monkey model of HIV, THC lowered neuroinflammation, suppressed inflammatory cytokine secretion, enhanced neurotrophic signaling & promoted survival of the astrocytes (the most predominant brain support cell), but prolonged exposure to high-dose THC negatively impacted survival of the glial cells (protection & nourishment for neurons)
THC Reverses SIV-Induced Senescence in Astrocytes: Possible Compensatory Mechanism Against HIV Associated Brain Injury?
https://pubmed.ncbi.nlm.nih.gov/40475423/

In immune T cells infected by HIV, THC suppression of immune system activation could influence the persistence of HIV in cellular reservoirs
Single cell multiomic analysis of the impact of Delta-9-tetrahydrocannabinol on HIV infected CD4 T cells
https://pubmed.ncbi.nlm.nih.gov/40502036/

📑 Reviews 📑

For female orgasmic difficulty, a review of 16 studies on the efficacy of cannabis
Cannabis for female orgasmic disorder/difficulty: a systematic review
https://academic.oup.com/smoa/article/13/4/qfaf061/8232583?login=false
And this thesis project found cannabis use linked to improved sexual functioning
A Mixed-Methods Investigation of the Relationship between Cannabis and Sexual Functioning Using Incentive Motivational Models
https://qspace.library.queensu.ca/items/8467e70b-f8f7-4690-abc2-8cc0967717fb
“More frequent cannabis use was linked with greater daily sexual desire. On sexual activity days, participants reported significantly higher sexual desire and arousal on days they used cannabis compared to non-use days. Across all study days (regardless of sexual activity), participants reported significantly higher sexual desire and lower sexual distress on days they used cannabis compared to non-use days. Sexual facilitation cannabis use expectancies moderated the relationship between same-day cannabis use and sexual distress: at mean and higher expectancies, sexual distress was significantly lower on cannabis use days compared to non-use days, whereas at lower expectancies, sexual distress did not differ across study days.”

For immune responses, a review on the effects of cannabis (nice charts)
Cannabis and the immune response: A comprehensive review of therapeutic potential and concerns
https://www.sciencedirect.com/science/article/pii/S2667031325001472

For autoimmune & rheumatic disorders, a review on the potential of cannabis
Exploring therapeutic potential of Cannabis based therapy in autoimmune and rheumatic disorders
https://www.sciencedirect.com/science/article/abs/pii/S1568997225001867

For targeting the cannabinoid receptors, a review of emerging tactics for improving clinical translation
Therapeutic Potential of Cannabinoid Receptors Type 1 and 2—Novel Insights for Enhancing the Chance of Clinical Success
https://www.mdpi.com/1424-8247/18/9/1324

For the CB1 receptor & psychosis, a review on its beneficial & harmful effects
CB1 receptor and psychosis: friend, foe, or both
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1630080/full

For hypertension & vascular diseases, on targeting the endocannabinoid system with thiazide diuretics acting via NAPE-PLD (which synthesizes anandamide)
State of the Art Review: Thiazide diuretics exploit the endocannabinoid system via NAPE-PLD
https://academic.oup.com/ajh/advance-article-abstract/doi/10.1093/ajh/hpaf174/8246171?redirectedFrom=fulltext

On anandamide, a comprehensive book on its biology
Anandamide in Health and Disease
https://www.sciencedirect.com/book/9780443190810/anandamide-in-health-and-disease

⚠️ Harms ⚠️

In public health data on cancer, people with cannabis use disorder had a 3x increase in oral cancer risk over five years
Cannabis use disorder and five-year risk of oral cancer in a multicenter clinical cohort
https://www.sciencedirect.com/science/article/pii/S2211335525002244

In public health data on lungs, inhaled cannabis use was associated with asthma & chronic obstructive pulmonary disease
Inhaled Cannabis, Asthma, and Chronic Obstructive Pulmonary Disease: A Population-Based Cross-Sectional Study of n = 379,049
https://link.springer.com/article/10.1007/s11606-025-09833-8

In people hospitalized for psychiatric intensive care, their withdrawal from cannabis can exacerbate their symptoms
Cannabis Withdrawal and Psychiatric Intensive Care
https://pubmed.ncbi.nlm.nih.gov/40498495/

In Germany, a net health analysis found the projected increases in adult consumption from legalization to result in approximately 2,300 more cases of severe long-term mental health conditions
A quantitative projection of the net health effects of cannabis legalization in Germany
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0330879
That feels like a pretty good estimate. However, on the net positive side, the only thing these researchers looked at was the reduced effects from contaminated cannabis. They didn't consider the many many people who will now feel more free to use cannabis as a medicine for their anxiety, pain & other conditions. Not to mention all the people not going to jail for it anymore…

For people with gastroesophageal reflux disease (GERD), cannabis use was associated with reflux esophagitis (damage of the esophageal lining from chronic acid reflux) or Barrett's esophagus (a precancerous condition where the normal cells lining the esophagus are replaced by cells more like those in the intestine)
Marijuana Use as a Lifestyle Factor Associated With Gastroesophageal Reflux Disease (GERD) Complications
https://pubmed.ncbi.nlm.nih.gov/40485749/

For cannabinoid hyperemesis syndrome in a psychiatric ward, on diagnosis & effective treatment
Cannabinoid hyperemesis syndrome: Diagnosis and effective treatment in a psychiatric ward
https://dusunenadamdergisi.org/storage/upload/pdfs/1755864495-en.pdf

The Thai national poison center reported ~1700 cases of cannabis product exposures from 2018 to 2022
Cannabis product exposures reported to Ramathibodi Poison Center, Thailand, during 2018–2022
https://www.tandfonline.com/doi/pdf/10.1080/15563650.2025.2536771

In a case report of a cannabis user with intussusception (one segment of the intestine slides into an adjacent part) fixed by robotic surgery
Robotic Bowel Resection for Adult Intussusception with History of Marijuana Use
https://pmc.ncbi.nlm.nih.gov/articles/PMC12410831/

A case report of someone using methadone & cannabis with ECG abnormalities & heart problems
The Electrocardiographic Conundrum in a Patient on Methadone Maintenance Therapy and Cannabis Coingestion: A Case Report of a Heartbreaking Puzzle
https://pubmed.ncbi.nlm.nih.gov/40488149/

In an 18-month-old, a cannabis edible caused status epilepticus (seizures lasting more than 5 minutes) & he had tremors for 4 days
Status Epilepticus After an Exploratory Ingestion of Cannabis Edibles
https://assets.cureus.com/uploads/case_report/pdf/407398/20250902-366663-2uz35v.pdf

In a mouse model of a leg break, those receiving buprenorphine & CBD had lower survival rates, with GI & cardio complications
Buprenorphine and Cannabidiol Co-Administration Reduces Survival in a Mouse Model of Orthopedic Trauma
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1683842/abstract

🐁 Preclinical 🐁

In a rat model of hernia repair, a CBD-impregnated surgical mesh prevented infections
The Effect of Cannabinoid-Impregnated Mesh on Infection Prevention in Hernia Repair: An Experimental Study in Rats
https://www.researchsquare.com/article/rs-7445598/v1

In a mouse model of rheumatoid arthritis, a high-CBD extract reduced inflammation & modulated immune responses
High CBD extract (CBD-X) modulates inflammation and immune cell activity in rheumatoid arthritis
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1599109/full

In a mouse model of obesity from a high-fat diet, dietary CBD reduced body weight & fat gain, lowered glucose & triglyceride concentrations & promoted thermogenesis in fat tissue
Dietary cannabidiol oil mitigates metabolic dysfunction in mice with high-fat diet-induced obesity
https://www.sciencedirect.com/science/article/pii/S0955286325002037

In a mouse model of schizophrenia, CBD reversed activation of the microglia (guardian immune cells of the brain) & deficits of the interneurons
Cannabidiol reverses microglia activation and deficits of parvalbumin interneurons and their perineuronal nets in a MK-801-induced mouse model of schizophrenia
https://pubmed.ncbi.nlm.nih.gov/40484109/

In a rat model of methamphetamine use disorder, CBD helped to extinguish their conditioned place preference (a sign of addiction) via dopamine receptors in the hippocampus (memory center of the brain)
D1-like dopamine receptors in the dentate gyrus mediate cannabidiol's facilitation of extinction and prevention of reinstatement in methamphetamine-induced conditioned place preference
https://www.sciencedirect.com/science/article/abs/pii/S0091305725001418

In rats, cannabis extracts from the São Francisco valley region of Brazil caused painkilling, anti-inflammatory & anti-dysmenorrheal effects
Antinociceptive, anti-inflammatory, and anti-dysmenorrheal activities of aerial parts of Cannabis sativa L. from the sub-middle region of the Vale do São Francisco
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1677987/abstract

In rats born to obese mothers, CBD lessened the inflammatory brain environment as well as their tendency towards apoptosis (programmed cellular suicide)
Cannabidiol regulates apoptosis and glial cells homeostasis in the prefrontal cortex of offspring from obese rat mothers
https://link.springer.com/article/10.1007/s11011-025-01687-7

In a rat model of working memory deficits from THC, a thesis project found terpenes minimized the effects
Terpenes Mitigate THC-Induced Working Memory Deficits: Behavioural Evidence of the Entourage Effect Using a 2-Component Operant Memory Task
https://scholars.wlu.ca/cgi/viewcontent.cgi?article=3986&context=etd

In a mouse model of Alzheimer's disease, peptides from hempseed protein reduced inflammatory factors & inflammation in the hippocampus (memory center of the brain), crossing both the intestinal & blood–brain barriers
Neuroavailable peptides from hempseed protein hydrolysates reduce hippocampal inflammation and glial activation in a scopolamine-induced Alzheimer’s disease
https://www.sciencedirect.com/science/article/pii/S0753332225006328

In a tissue model of Parkinson's disease, CBD increased cell viability & decreased apoptosis (programmed cellular suicide) via regulation of genetic transcription & the Nrf2 signaling pathway
Cannabidiol Extracted from Cannabis sativa L. Plant Shows Neuroprotective Impacts Against 6-HODA-Induced Neurotoxicity via Nrf2 Signal Transduction Pathway
https://brieflands.com/articles/ijpr-160499

For the mpox virus, a computer analysis suggested the minor cannabinoid trans-cannabitriol blocked adhesion
Trans-Cannabitriol as a Dual Inhibition of MPOX Adhesion Receptors L1R and E8L: An In Silico Perspective
https://journals.sagepub.com/doi/pdf/10.1177/11779322251355315

For drug interactions, an analysis of CBD, THC & their metabolites as inhibitors of UDP-glucuronosyltransferases (enzymes that detoxify the body), with CBD being the strongest
Predicting in vivo cannabinoid-drug interactions mediated via inhibition of UDP-glucuronosyltransferases using in vitro studies and physiologically based pharmacokinetic modeling and simulations
https://pubmed.ncbi.nlm.nih.gov/40482431/

For the painkilling effects of paracetamol, its metabolite, the cannabinoid AM404, acted by inhibiting sodium channels in the pain-sensing neurons
The analgesic paracetamol metabolite AM404 acts peripherally to directly inhibit sodium channels
https://pubmed.ncbi.nlm.nih.gov/40465624/
And in mice, the painkiller acetaminophen lowered pain through CB1 receptors & the DAGL enzyme (which produces 2-AG)
Acetaminophen attenuates pathological pain through a mechanism that requires CB1 cannabinoid receptors and the enzyme diacylglycerol lipase in mice
https://pubmed.ncbi.nlm.nih.gov/40463236/
And two more to add to our list of drugs that work by the endocannabinoid system…

🆕 Novel Studies 🆕

(my grab bag section for stuff I haven’t quite seen before)

The trichomes of modern cannabis are larger & more productive than their landrace ancestors
Bigger is Better; Modern Cannabis Trichomes are Larger and More Productive than their Landrace Ancestors
https://academic.oup.com/pcp/advance-article-abstract/doi/10.1093/pcp/pcaf105/8245728?redirectedFrom=fulltext

For epilepsy, CBD-loaded lipid nanocarriers for nose-to-brain delivery
Cannabidiol-Loaded Nanostructured Lipid Carriers for Nose to Brain Delivery: An Effective Therapeutic Approach against Epilepsy
https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.5c00452
Not to get distracted, but I too want to be able to snort my cannabinoids. When smoking, one kid complains of “papa smell” (while the other one enjoys the odor).

Analysis of an AI medical system running cannabis therapy for pain patients
A constrained disorder principle-based second-generation artificial intelligence digital medical cannabis system: A real-world data analysis
https://pubmed.ncbi.nlm.nih.gov/40496893/

📰 US Headlines & Fav Articles 📰

The Department of Justice withdrew a number of rules, including for easing cannabis research & on hemp testing
https://www.marijuanamoment.net/trump-administration-moves-to-cancel-pending-marijuana-and-hemp-rules/

An editorial against the rescheduling of cannabis
Rescheduling Cannabis-Medicine or Politics?
https://pubmed.ncbi.nlm.nih.gov/40498499/
And an analysis of the public response towards the cannabis rescheduling proposal showed mixed results, with the early respondents being positive & the later, negative
Public Attitudes Toward the Drug Enforcement Administration’s Proposal to Reschedule Marijuana: A Cross-Sectional Mixed-Methods Analysis
https://karger.com/mca/article/8/1/117/928534/Public-Attitudes-Toward-the-Drug-Enforcement

Quest Diagnostics said cannabis is the most detected drug in the workforce, with a positivity rate of 4.5%
https://www.prnewswire.com/news-releases/fentanyl-positivity-is-more-than-seven-times-higher-in-random-tests-vs-pre-employment-drug-screening-finds-2025-quest-diagnostics-drug-testing-index-302543110.html

‘California’s Small Cannabis Farmers Have Been Left High and Dry’
https://www.thenation.com/article/society/california-small-cannabis-farmers-weed-legalization/

‘Migrants apprehended in marijuana farm raids recount living nightmare’
https://www.reuters.com/world/us/migrants-apprehended-marijuana-farm-raids-recount-living-nightmare-2025-08-13/

In Massachusetts, a mother detained by ICE over a 2003 cannabis case sparks anger & a legal battle
https://cannabislaw.report/article-massachusetts-mother-detained-by-ice-over-2003-marijuana-case-sparks-anger-and-legal-battle/

On the arrest of the Mass. sheriff for extortion of a cannabis company
https://talkingjointsmemo.com/the-shakedown-sheriff-how-steven-tompkins-nickel-and-dimed-his-way-to-indictment/

Aug 28, 1964: when Bob Dylan turned on the Beatles
https://projectcbd.org/health/when-bob-dylan-turned-on-the-beatles/

On India & cannabis, a review of an excellent looking new book: ‘Ananda: An Exploration of Cannabis in India’
https://frontline.thehindu.com/books/india-cannabis-laws-history-farming-medicine/article69955593.ece
It's only published in India right now but the author assured me it should be out in the US soon.

🌐 International Updates 🌐

In France, plans to “fully integrate” cannabis into the healthcare system
https://cannabishealthnews.co.uk/2025/08/06/frances-plans-to-fully-integrate-medical-cannabis-into-its-healthcare-system/

In Thailand, up to 18K stores may close down amid the government's reversal on cannabis
https://cannabislaw.report/australian-media-report-says-up-to-18000-thai-cannabis-stores-will-close-down/
Except that the country just got a new prime minister: Anutin Charnvirakul, the "Cannabis King"& architect of the 2022 cannabis legalization law
https://www.bbc.com/news/articles/cr4q051zxgyo

In Israel, organized crime using “legal” cannabis companies to divert product to the illicit market
https://cannabislaw.report/israel-police-operation-reveals-legal-cannabis-companies-used-by-criminal-organisation-to-divert-product-to-illicit-market/

In São Paulo, free CBD at municipal network pharmacies
https://sechat.com.br/en/noticia/free-cannabidiol-in-sao-paulo-see-how-the-work-will-be-and-the-list-of-diseases

Mexico City opens cannabis consumption spaces
https://www.abc.es/sociedad/ciudad-mexico-estrena-paraisos-fumar-marihuana-medio-20250824194508-vi_amp.html

In Sierra Leone on the impacts of the use of synthetic cannabinoids (“Kush”)
Synthetic Cannabinoids in Sierra Leone: Understanding the Use of 'Kush' Among Youths and Its Socioeconomic Impact in Sierra Leone and Sub-Region
https://pubmed.ncbi.nlm.nih.gov/40496109/

In Brazil, on the “technoconservatism, denialism & moral panic” shaping the medical cannabis debates
Technoconservatism, scientific denialism, and moral panic: health communication, disinformation on medicinal cannabis, and the right to health in Brazil
https://www.researchgate.net/publication/395193403_Technoconservatism_scientific_denialism_and_moral_panic_health_communication_disinformation_on_medicinal_cannabis_and_the_right_to_health_in_Brazil

In Australia, an analysis of constitutional Section 113 & its implications for regulating recreational cannabis oil
Section 113 of the Constitution and Its Impact on the Regulation of Cannabis Oil for Recreational Purposes
https://pubmed.ncbi.nlm.nih.gov/40481650/
And an analysis of Aussie illicit street cannabis found THC levels to be lower than the rest of the world, but trending higher
Cannabis in the wild: Analysis of street cannabis and cannabinoid composition in Australia
https://www.sciencedirect.com/science/article/pii/S0955395925002701

In Poland, on the potential of hemp for medicine & agriculture
Hemp in Poland - the importance of social communication and health education in using the plant's potential in medicine, economy and agriculture - current status
https://pubmed.ncbi.nlm.nih.gov/40446103/

⚖️ Business, Laws & Education ⚖️

On the intricacies of the GTI/Agrify deal
https://cannabismusings.substack.com/p/cannabis-musings-september-2-2025

In California’s Emerald Triangle, on cannabis agritourism through service-dominant logic
Cultivating cannabis agritourism: Integrating service-dominant logic in Northern California’s Emerald Triangle
https://www.sciencedirect.com/science/article/pii/S0743016725003055

On how Pax got product placement into popular media
Efforts to secure nicotine and cannabis product placements in popular media by Ploom, Pax, and Juul: an analysis of tobacco industry documents
https://pubmed.ncbi.nlm.nih.gov/40899689/

On how cannabis vape products are marketed online
Content Analysis of Derived Intoxicating Cannabis Vape Product Attributes and Marketing In an Online Retail Environment
https://www.tandfonline.com/doi/full/10.1080/10826084.2025.2555499

🚓 The War on Drugs 🚓

On the legal issues raised by Trump’s assassination strike of an alleged drug smuggling vessel in the Caribbean
https://www.justsecurity.org/119982/legal-issues-military-attack-carribean/

In Indonesia, President Prabowo wants the country to be a “killing ground” for drug dealers
https://cannabislaw.report/antara-prabowo-wants-indonesia-as-killing-ground-for-drug-dealers-official/

On the smuggling of California cannabis to the UK on passenger flights
https://www.nytimes.com/2025/09/01/world/europe/california-uk-cannabis-smuggling.html

Analyzing the link between cocaine trafficking and & underground banking
The nexus between cocaine trafficking and underground banking
https://www.tandfonline.com/doi/abs/10.1080/17440572.2025.2553242

In Australia, a review of 80,000 strip searches found that more than 85% found nothing
https://cannabislaw.report/australia-new-report-shows-over-80000-strip-searches-conducted-in-nsw-in-10-years-with-more-than-85-finding-nothing/

A history of China's drug bans
https://www.talkingdrugs.org/playing-whack-a-mole-a-history-of-chinas-drug-bans/

Being a member of the anti-laundering Financial Action Task Force did reduce that country’s total crime, but increases for corruption & fraud & little effect on violent & property crimes
Do the international anti-money laundering standards reduce crimes? Evidence from FATF members
https://link.springer.com/article/10.1007/s43508-025-00120-0

In Singapore & the Philippines, an analysis of their self-constructed “official drug narratives”
Drug-free nation: Reconstructing the ‘official drug narratives’ in Singapore and the Philippines
https://www.sciencedirect.com/science/article/abs/pii/S0955395925002439

‘The Opium Balloon: Taliban Crackdown Moves Opium Market to Pakistan’
https://www.talkingdrugs.org/the-opium-balloon-taliban-crackdown-moves-opium-market-to-pakistan/
“‘The Balloon effect’ broadly refers to the phenomenon whereby suppressing production in one area causes it to shift elsewhere – much like squeezing a filled balloon, where pressure in one spot causes expansion in another. When pressed, the air does not disappear; it moves to another area of lesser resistance. The drug market behaves similarly”.

On the rise of at-sea drop-offs of drugs into the UK
https://www.theguardian.com/world/2025/aug/02/uk-public-gangs-drugs-mother-ships-national-crime-agency
And on a 2-ton cocaine bust in the Irish Sea – but that’s barely a drop in the ocean
https://www.bbc.com/news/articles/c5yvplyrrwno
“Eight men were convicted and jailed for a total of 129 years. All of the cocaine was destroyed.
But despite this result, law enforcement agencies across Europe admit they are struggling to stop the growing quantity of cocaine crossing the Atlantic from South America. The Maritime Analysis Operations Centre (MAOC), which polices the transatlantic drug trade, says 100 ships suspected of trafficking drugs to Europe were not stopped last year because the authorities didn't have enough vessels to intercept them.
"We have the intelligence of the vessel that's crossing the Atlantic... that it's loaded at that time, and still we don't have the interception assets available," its director, Sjoerd Top, tells Panorama.””

Dutch police with a 1600 kg cocaine bust
https://cannabislaw.report/netherlands-police-seize-1600-kilograms-of-cocaine-in-gorinchem-and-ede-four-arrested/

Guatemalan mayor extradited to the US on a drug trafficking conspiracy charge
https://cannabislaw.report/corrupt-guatemalan-mayor-extradited-to-united-states-on-drug-trafficking-conspiracy-charge/

In Morocco, a 2000-ton hashish bust at sea
https://cannabislaw.report/morocco-sidi-ifni-police-seize-nearly-2000-tons-of-hashish-halt-illegal-sea-voyage/

A California man was charged with murder after an explosion at his illegal cannabis lab killed five
https://cannabislaw.report/california-temple-city-man-charged-with-murder-in-explosions-that-killed-5-at-illegal-cannabis-labs/

A Lagos pastor arrested for shipments of over 900 kg of cannabis
https://cannabislaw.report/praise-the-lord-ndlea-arrests-lagos-pastor-over-900kg-cannabis-shipments-from-ghana/

🛡️ Harm Reduction News 🛡️

RIP Monte Levine: early hero of needle exchanges
https://eu.kitsapsun.com/story/news/2025/09/02/needle-exchanges-evolved-in-wa-though-feds-now-threaten-method/85840090007/

‘Overdoses Should Be Termed “Prohibition-Related Deaths”’
https://filtermag.org/overdose-prohibition-related-deaths/

In Tennessee, a harm reductionist faces charges for drug checking
https://filtermag.org/tennessee-harm-reductionist-arrested-drug-checking/

In New York, Mayor Adams is pushing for an involuntary commitment law for substance use disorder
https://filtermag.org/new-york-involuntary-commitment-substance-use/

Ethylbromazolam: a new benzodiazepine
https://www.talkingdrugs.org/ethylbromazolam-the-new-global-benzodiazepine/

An anti-harm reduction think piece
https://quillette.com/2025/08/16/rethinking-harm-reduction-drug-addiction-san-francisco/
And on SF, Philly & other cities moving away from harm reduction
https://www.nytimes.com/2025/08/25/health/harm-reduction-san-francisco-trump.html

Harm Reduction Research

For safer opioid supply programs, a review of client preferences
Safer opioid supply clients’ values and preferences: a systematic review and thematic synthesis of qualitative research
https://mentalhealth.bmj.com/content/ebmental/28/1/e301629.full.pdf

For take-home naloxone programs, a review of their efficacy in bridging emergency response & prevention
Bridging Emergency and Prevention: A Systematic Review of Take-Home Naloxone Programs
https://pubmed.ncbi.nlm.nih.gov/40846320/

For harm reduction & criminalization, interviews with people who use drugs about the strong contradictions
“They won’t prosecute, but they will though:” the continuing struggle between criminalization and harm reduction within the criminal justice system in the context of an opioid overdose crisis
https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-025-01284-y

In women with substance use disorders, a thesis project on their stigma
A Phenomenological Qualitative Study: The Lived Experiences of Women Diagnosed with Substance Use Disorders and the Stigma Associated with Their Disorder
https://digitalcommons.liberty.edu/cgi/viewcontent.cgi?article=8434&context=doctoral

In Northern Ontario, the closure of one of the only supervised consumption sites led to negative individual & community impacts
Necropolitics of the North: A rapid ethnography examining the effects of the closure of one of Northern Ontario’s only supervised consumption sites
https://www.sciencedirect.com/science/article/pii/S0955395925001690
And there’s allegations that groups misrepresented evidence to close the site
https://www.barrietoday.com/local-news/group-claims-province-misrepresented-evidence-to-close-ottawa-scs-11098731

On tribally-affiliated syringe services programs
Tribally-affiliated syringe services programs in the United States: a brief report
https://pubmed.ncbi.nlm.nih.gov/40826458/

In Georgia, pharmacies, syringe access remains rare despite policy changes permitting sales
Sterile syringe availability in Georgia pharmacies remained rare, despite policy change permitting sales
https://pubmed.ncbi.nlm.nih.gov/40819053/

In Jammu City, India, an ethnographic study of a de-addiction clinic
Drugs, Dependency, and De-Addiction in Jammu City, Jammu and Kashmir, India
https://www.proquest.com/openview/ccfaa5d353f517b89682c43f29989654/1?pq-origsite=gscholar&cbl=18750&diss=y

On lessons implementing a syringe service program in a primary care clinic
Implementation of an Interdisciplinary Syringe Services Program Within a Primary Care Clinical Setting
https://pubmed.ncbi.nlm.nih.gov/40846323/

On the importance of nursing curriculum framing substance use as brain-based disorders
"If people don't understand these are brain-based disorders… They don't understand the person who's in front of them:" Substance use-related content for nurse practitioner curricula
https://pubmed.ncbi.nlm.nih.gov/40856550/

For people who use drugs, a survey on the effects of racial attitudes on harm reduction access
Intersecting stigmas: How racial attitudes shape support for treatment and harm reduction for people who inject drugs
https://pubmed.ncbi.nlm.nih.gov/40819628/

In Rhode Island harm reduction, on the gender differences in people who use drugs
Gender-based differences in harm reduction practices among people who use drugs in Rhode island: a latent class analysis
https://pubmed.ncbi.nlm.nih.gov/40820201/

In the Middle East & North Africa, on the burden of opioid use disorder
Burden of opioid use disorder in the Middle East and North Africa (MENA): findings from Global Burden of Disease (GBD) study
https://link.springer.com/article/10.1186/s41043-025-01029-4

🍄 Psychedelics, Plant Medicines & Other Psychoactives 🍄

Bust of a Spanish spiritual retreat offering ayahuasca, San Pedro & Kambo
https://www.scmp.com/news/world/europe/article/3321534/spain-police-bust-spiritual-retreat-offering-frog-venom-other-psychedelics

‘Yes, DMT Aliens Might Be Real...’
https://alieninsect.substack.com/p/yes-dmt-aliens-might-be-real

The Psychoactive Research

In people with eating disorders, a survey on the benefits & risks
Psychedelic use in individuals living with eating disorders or disordered eating: findings from the international MED–FED survey
https://jeatdisord.biomedcentral.com/articles/10.1186/s40337-025-01328-5
And in people with eating disorders, there's some evidence for the therapeutic benefits of cannabis & psychedelics
Prescription and Nonprescription Drug Use Among People With Eating Disorders
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2836693

For veterans in naturalistic retreat settings, on the therapeutic effects of psychedelics
Exploring the Therapeutic Effects of Psychedelics Administered to Military Veterans in Naturalistic Retreat Settings
https://onlinelibrary.wiley.com/doi/10.1002/brb3.70660

For PTSD, a case study of the METEMP protocol of MDMA-enhanced massed exposure therapy
A Case Study of the METEMP Protocol: Massed Exposure Therapy Enhanced With 3,4-Methylenedioxymethamphetamine (MDMA) for Posttraumatic Stress Disorder
https://www.sciencedirect.com/science/article/abs/pii/S1077722925000045

For PTSD, a model combining MDMA with trauma-focused CBT
A New Generation of Psychedelic-Assisted Psychotherapy: The Example of Combining MDMA With Trauma-Focused Cognitive-Behavioral Therapy for Posttraumatic Stress Disorder
https://www.sciencedirect.com/science/article/abs/pii/S1077722925000422

Psychedelics & meditation opened similar types of insights into mystical, psychological & philosophical questions
Meditation and psychedelics facilitate similar types of mystical, psychological, and philosophical-existential insights predictive of wellbeing: a qualitative-quantitative approach
https://www.sciencedirect.com/science/article/pii/S1053810025000947?via%3Dihub

In psychedelic therapy, on how the mystical effects were correlated with positive outcomes & the fearful effects did not predict negative outcomes
The phenomenology of psilocybin’s experience mediates subsequent persistent psychological effects independently of sex, previous experience, or setting
https://link.springer.com/article/10.1007/s43440-025-00742-5

A case report of psychedelics for social anxiety disorder
Utilizing in Vivo and Imaginal Exposure in the Context of MDMA-Assisted Therapy for Social Anxiety Disorder: A Case Report
https://www.sciencedirect.com/science/article/abs/pii/S1077722925000057

A case report of kratom linked to parapneumonic effusion (fluid buildup between the chest & lungs)
Development of Parapneumonic Effusion in a Patient Using Kratom
https://scholarlyworks.beaumont.org/internal_medicine_confabstract/684/

On psychedelics for pain, a review of the mechanisms & evidence
Classic Psychedelics in Pain Modulation: Mechanisms, Clinical Evidence, and Future Perspectives
https://pubs.acs.org/doi/10.1021/acschemneuro.5c00152

On MDMA for PTSD, a review of the literature
MDMA-assisted therapy and current treatment options for chronic, treatment-resistant, moderate or higher severity post-traumatic stress disorder: Systematic literature review
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0327778

For neurologic & psychiatric disorders, a review on the role of psychedelics
Psychedelics in the Treatment of Neurologic and Psychiatric Disorders: Coincidence or a New Point of View
https://link.springer.com/article/10.1007/s12035-025-05097-9

For suicide prevention, on the molecular mechanisms of psilocybin
The molecular mechanisms through which psilocybin prevents suicide: evidence from network pharmacology and molecular docking analyses
https://www.nature.com/articles/s41398-025-03410-7

🍃 The Plant & its Products 🍃

🌱 Growing & Extracting 🌱

For long fiber hemp, on the effects of cultivar, nitrogen fertilization & sowing density
The Influence of Variety, Nitrogen Level and Sowing Density on the Productivity of Long Fiber Hemp
https://www.tandfonline.com/doi/pdf/10.1080/15440478.2025.2549917

In Mid-Atlantic industrial hemp, early planting boosted yield & fiber quality, but was flexible
Early establishment increases yield and fiber quality of industrial hemp (Cannabis sativa L.) produced in the Mid‐Atlantic
https://acsess.onlinelibrary.wiley.com/doi/pdf/10.1002/agg2.70184

On the best substrates for cannabis growth
Optimizing simplified growing media to enhance cannabis cultivation
https://li04.tci-thaijo.org/index.php/IJAT/article/view/5844

In a Thai cultivar, the effects of pulsed light spectra on cannabinoid levels
Effects of Pulsed Light Spectra on Cannabinoid Accumulation in Thai Cannabis sativa L. ‘Hang Kra Rog Phu Phan ST1’
https://ph02.tci-thaijo.org/index.php/RIST/article/view/260713

On the effects of water on fiber structure & hemp tissue
Long-term water migration in hydrated corn stalk pith and hemp stalk by 250 MHz NMR relaxometry and diffusometry
https://www.sciencedirect.com/science/article/pii/S2666441025000263

When protecting from weeds with herbicides, the yield of hemp can decrease
The peculiarities of segetal vegetation control on hemp (Cannabis sativa L.) sown areas
https://www.researchgate.net/publication/394761592_Osoblivosti_kontrolu_segetalnoi_roslinnosti_v_posivah_konopel_posivnih_Cannabis_sativa_LThe_peculiarities_of_segetal_vegetation_control_on_hemp_Cannabis_sativa_L_sown_areas

For rapid prediction of cannabis chemotype, a PCR-based assay to measure levels of the THCAS & CBDAS enzymes (that produce THC & CBD)
Rapid Specific PCR Detection Based on THCAS and CBDAS for the Prediction of Cannabis sativa Chemotypes: Drug, Fiber, and Intermediate
https://pubmed.ncbi.nlm.nih.gov/40507888/

On quantifying CBDA content with near-infrared hyperspectral imaging
On a direct method to estimate cannabidiolic acid content of Cannabis sativa L. from near-infrared hyperspectral images
https://ieeexplore.ieee.org/abstract/document/11079118

A Polish study on the sustainability of hemp farms
Assessing the sustainability of hemp farms: a case study using the FAO SAFA tool
https://www.researchgate.net/publication/395169199_Assessing_the_sustainability_of_hemp_farms_a_case_study_using_the_FAO_SAFA_tool

For extraction, on the effects of different solvents on polyphenolic yield
INFLUENCE OF VARIOUS SOLVENTS ON THE POLYPHENOLIC COMPOSITION OF EXTRACTS FROM CANNABIS SATIVA L. AND CANNABIS INDICA PLANTS
https://www.researchgate.net/publication/395240019_INFLUENCE_OF_VARIOUS_SOLVENTS_ON_THE_POLYPHENOLIC_COMPOSITION_OF_EXTRACTS_FROM_CANNABIS_SATIVA_L_AND_CANNABIS_INDICA_PLANTS

On a one-step supercritical CO2 co-extraction of hemp flowers & seeds into a CBD oil
Single-step production of ready-to-use cannabidiol oils via supercritical CO2 co-extraction of hemp flowers and seeds
https://www.sciencedirect.com/science/article/pii/S2212982025001982

⚙️ Analyzing & Formulating ⚙️

On identifying cannflavins with an HPLC–UV/PDA
Development and Validation of an HPLC–UV/PDA Method for the Determination of Cannflavins in Different Cannabis sativa Chemovars
https://www.mdpi.com/2409-9279/8/5/100

For hemp seed oil, on the effects of drying methods
Investigating the Influence of Drying Methods on the Quality and Bioactive Properties of Hemp (Cannabis sativa L.) Seed Oil
https://pubmed.ncbi.nlm.nih.gov/40901649/

On analyzing the peroxide levels in hemp seed oil
Analytical Methods for Determining the Peroxide Value of Hemp Seed (Cannabis Sativa L.) Oil
https://www.researchgate.net/publication/395032327_Analytical_Methods_for_Determining_the_Peroxide_Value_of_Hemp_Seed_Cannabis_Sativa_L_Oil

On detecting CBD with simple voltammetric methods
Electrochemical sensing of cannabidiol in pharmaceutical dosage forms using modification-free carbon-based electrodes: A voltammetric approach for on-site detection
https://www.sciencedirect.com/science/article/abs/pii/S0013468625016482

🍞 Food, Nutrition & Hemp Seeds 🍞

For hemp seeds, a review on their nutrients & bioactive compounds
Nutrients and Bioactive Compounds from Cannabis sativa Seeds: A Review Focused on Omics-Based Investigations
https://pubmed.ncbi.nlm.nih.gov/40508032/

On gluten-free bakery products with hemp oil
Assisted Extraction of Hemp Oil and Its Application to Design Functional Gluten-Free Bakery Foods
https://www.mdpi.com/1420-3049/30/12/2665

In different cheeses, on the levels of endocannabinoid-like compounds, with Danish blue having the most
Effects of fermentation, ripening and storage on endocannabinoids and endocannabinoid-like compounds in different cheeses
https://www.sciencedirect.com/science/article/abs/pii/S0308814625034995

For brewing, hemp seeds enriched barley wort
Evaluation of the Profile of Selected Bioactive Compounds and the Potential of Barley Wort Enriched with Malted and Unmalted Hemp Seeds for Brewing Applications
https://www.mdpi.com/1420-3049/30/15/3261

On enhancing wheat bread with hemp flour
Enhancing wheat-bread with hemp flour: Impact on chemical, volatile, and sensory properties
https://www.sciencedirect.com/science/article/abs/pii/S0963996925017776

In chutney, on incorporating hemp seeds
Hemp seeds (Cannabis sativa L.) Incorporated Chutney: A Step Toward Functional Foods
https://www.ocl-journal.org/articles/ocl/pdf/2025/01/ocl250019.pdf

For choux pastry, on the changes caused by adding hemp protein concentrate
Technofunctional and sensory impact of hemp seed protein concentrate on the quality of enriched choux pastry
https://repository.utm.md/handle/5014/32639

In laying hens, a water-soluble CBD emulsion increased yolk polyunsaturated fatty acid & blood HDL levels
Dose-dependent effects of Cannabidiol in drinking water on yolk fatty acid profile and hepatic expression of PUFA-related genes in laying hens: insights into the CBD systemic and molecular mechanisms of action
https://www.researchsquare.com/article/rs-7387031/v1

In dairy cows, a combination of hemp seeds & stevia leaves did not alter their milk yield or composition, but hemp hay improved their milk’s monounsaturated fatty acid content
Effects of stevia (stevia rebaudiana) and hemp by-products (cannabis sativa) on milk yield, fatty acid profile, and oxidative stability in dairy cows
https://pubmed.ncbi.nlm.nih.gov/40692352/

A method for extracting high-purity hemp seed protein sustainably from hemp seed cake
Sustainable recovery and characterization of high-purity hemp seed protein concentrate for functional food innovation
https://repository.utm.md/handle/5014/32644

🏗️ Industrial Uses & Fiber 🏗️

On the engine effects from a hemp biodiesel
A comprehensive evaluation of the impact of compression ratio on performance, combustion, and emissions of hemp biodiesel-fueled direct injection diesel engine
https://www.sciencedirect.com/science/article/abs/pii/S001623612502352X

For creating biodiesel from waste cooking oil & hemp shives
Co-processing of waste cooking oil and hemp-shives for an intensified production of advanced biodiesel
https://research.tees.ac.uk/en/publications/co-processing-of-waste-cooking-oil-and-hemp-shives-for-an-intensi

On hemp geotextiles for road infrastructures
Effects of ageing in a saturated environment on the functional properties of hemp geotextiles
https://www.e3s-conferences.org/articles/e3sconf/abs/2025/44/e3sconf_eurogeo82025_01002/e3sconf_eurogeo82025_01002.html

On using hemp fiber/polyaniline composites for vibration damping
Dielectric, Electrorheological Efficiency and Creep‐Recovery Characteristics of Vibration Damping Industrial Hemp Fiber/Polyaniline Composite
https://4spepublications.onlinelibrary.wiley.com/doi/abs/10.1002/pc.70409

For optimizing furniture made from polypropylene & hemp fiber
OPTIMIZATION OF THERMOFORMING OF POLYPROPYLENE AND HEMP FIBER COMPOSITE MATERIALS EGG CARTON SHAPE PARTS BY RADIUS PROFILE AND PITCH
https://atna-mam.utcluj.ro/index.php/Acta/article/viewFile/2750/2165

On using carbonized hemp fiber in composite materials
Carbonized Hemp Fiber for Use in Composites
https://pubmed.ncbi.nlm.nih.gov/40508507/

In hemp fiber geopolymer composites, they had better fire resistance & thermal efficiency but decreased mechanical properties
Physical Structural Mechanical and Thermal Insulation Properties of Hemp Fiber-Substituted Geopolymer Composites
https://pubmed.ncbi.nlm.nih.gov/40508539/

On using industrial hemp waste as a feedstock for producing bacterial cellulose
A sustainable strategy for biosynthesis of bacterial cellulose using a microbial symbiotic culture from hemp (Cannabis sativa L.) waste hydrolysate
https://www.sciencedirect.com/science/article/pii/S0926669025010556

For denim fabrics, on the performance effects of hemp fibers
EVALUATION OF THE EFFECT OF HEMP FIBERS ON THE PERFORMANCE PROPERTIES OF DENIM FABRICS
https://www.cellulosechemtechnol.ro/firstonline.php
And for denim enhancement with hemp fiber, on using ozone fading in the washing process
An Analysis of the Efficient Fading Through Ozone Technology and Washing for Denim Fabrics Enhanced with Hemp Fibre
https://www.tandfonline.com/doi/abs/10.1080/01919512.2025.2535437

An analysis of fiber extraction possibilities from cannabis
Studying the Cannabis Sativa L plant and the possibilities of obtaining fiber from it
https://pubs.aip.org/aip/acp/article-abstract/3304/1/040013/3354775/Studying-the-Cannabis-Sativa-L-plant-and-the

In Pakistan, a review of the prospects of hemp fiber
Implications, challenges and prospects of industrial hemp as a sustainable natural fiber in Pakistan: An overview
https://www.researchgate.net/publication/393640448_Implications_challenges_and_prospects_of_industrial_hemp_as_a_sustainable_natural_fiber_in_Pakistan_An_overview

For undergrads, on using hemp-lime projects for teaching opportunities
Hemp-lime as a tool for undergraduate research and teaching experiences
https://www.frontiersin.org/journals/sustainability/articles/10.3389/frsus.2025.1621197/full

🌿 THE CANNA-SCIENCE ARCHIVE 🌿

For bhang (the cannabis drink of India), a review of its help for pain, inflammation, & mood
Cannabinoids as Multi-Target Agents: Exploring Bhang in Pain, Inflammation, and Mood Disorders
https://www.researchgate.net/publication/393823447_Cannabinoids_as_Multi-Target_Agents_Exploring_Bhang_in_Pain_Inflammation_and_Mood_Disorders

🏥 Public Health, Legalization Effects & Bioassays 🏥

In a survey of US medical cannabis users & the effects of state law on their use, the majority were using it for anxiety, depression & chronic pain with smoking being the most common ingestion method, but many in prohibition states feared reporting their use to their primary care provider
Medical Cannabis Utilization Across States With Varying Legal Status
https://www.sciencedirect.com/science/article/pii/S2773065425000847

In California, on the reasons people were using cannabis
Self-Reported Therapeutic Cannabis Use and Reasons for Use among Adult Cannabis Consumers in California (ACCC)
https://apha.confex.com/apha/2025/meetingapi.cgi/Paper/565088?filename=2025_Abstract565088.pdf&template=Word

In older adults in NYC, on the effects of cannabis usage
Lifetime Cannabis Use and Consequences in a Community-Based Sample of Older Adults
https://www.tandfonline.com/doi/abs/10.1080/10826084.2025.2548306

In Japan, interviews on why people use cannabis
Why do you smoke cannabis? Qualitative interviews of Japanese cannabis users
https://journals.sagepub.com/doi/full/10.1177/20503245251362489

In Canadian drivers, a random survey of positive THC results for commercial & non-commercial drivers
Drug prevalence in Canadian driving population
https://pubmed.ncbi.nlm.nih.gov/40504675/

In middle-aged & older US adults, those with poorer physical & mental health were more likely to report the past-month co-use of cannabis & tobacco
Prevalence and correlates of tobacco and cannabis co-use among late middle-aged (50-64 years) and older adults (65+ years) in the United States using pooled national survey data
https://pubmed.ncbi.nlm.nih.gov/40476547/

On THC detection in blood & urine with a new ionic liquid-based microextraction method
Introduction and development of smart ionic liquids (SMILs) in microextraction process: A novel methodology for the quantitative detection of THC as a biomarker of nicotine in smokers' urine and serum
https://pubmed.ncbi.nlm.nih.gov/40484547/

In human blood, on measuring CBD & its metabolites with an LC-MS/MS method
Development and validation of a high-throughput LC-MS/MS bioanalytical method for the simultaneous quantification of cannabidiol and metabolites in human plasma
https://pubmed.ncbi.nlm.nih.gov/40482367/

Verifying the urine cannabinoid test on the Abbott Alinity ci platform
Verification of the analytical performance of the urine cannabinoids immunoassay on the Abbott Alinity CI
https://www.elibrary.ru/item.asp?id=81575309

In hair analysis, a year of storage decreased the levels of endocannabinoids & other analytes
Hair cortisol and other hair analytes decline with storage over a one-year period: A systematic, within-subject investigation
https://www.sciencedirect.com/science/article/pii/S0306453025003166

🧒 Adolescents & Young Adults 🧒

On cannabis use in childhood & adolescence, a review on the chronic health effects
Chronic Health Effects of Cannabis Use in Childhood and Adolescence
https://pubmed.ncbi.nlm.nih.gov/40489359/

For college students with positive experiences of cannabis, they were more likely to have a sexual minority orientation
A Higher Education: Age, Sex, and Sexual Orientation as Indicators of Positive Cannabis Use Consequences Among College Students
https://www.tandfonline.com/doi/abs/10.1080/10826084.2025.2533980

In an adolescent cohort, earlier initiation of cannabis was linked to higher levels of cannabis use disorder
Longitudinal study of risk factors predicting cannabis use disorder in UK young adults and adolescents
https://www.nature.com/articles/s43856-025-01018-y

In young adults, exposure to cannabis vape product advertising was linked to increased usage
Cannabis vape product advertising exposure is associated with cannabis vape product use and frequency among U.S. Young adults
https://www.sciencedirect.com/science/article/pii/S0306460325002369

In adolescent cannabis use, the effects of housing instability, race/ethnicity & sexual identity
Housing instability, race/ethnicity, and sexual identity as intersectional factors in adolescent cannabis use
https://www.sciencedirect.com/science/article/abs/pii/S0306460325002370

For adolescents in rural reservation-based communities, the strongest predictor of alcohol & cannabis use was easy home & adult access
Unlocking use: Sources of perceived access and adolescent alcohol and cannabis use in rural reservation-based communities
https://apha.confex.com/apha/2025/meetingapi.cgi/Paper/566198?filename=2025_Abstract566198.html&template=Word

In undergrads, cannabis use was linked to an increased odds of excessive social media use (16+ hours per day)
Examining Cannabis Use Across Communities: Trends, Determinants, and Implications
https://apha.confex.com/apha/2025/meetingapi.cgi/Session/74368?filename=2025_Session74368.pdf&template=Word

In a virtual reality room, undergrad cannabis users preferred being around the rooms of cannabis equipment
Conditioned place preferences for virtual reality cannabis cues
https://psycnet.apa.org/record/2026-56973-001
#same

In young adults experiencing psychosis, an intervention for reducing heavy cannabis use
Development of a motivational enhancement therapy cannabis-reduction intervention for young adults experiencing psychosis: A feasibility pilot study.
https://psycnet.apa.org/record/2026-41806-001

For youth cannabis use disorders, an analysis of the screening tool Cannabis Use Disorders Identification Test–Revised (CUDIT-R)
Psychometric Performance of the Cannabis Use Disorders Identification Test– Revised (CUDIT-R) in an Youth Clinical Sample
https://link.springer.com/article/10.1007/s10597-025-01494-5

In adolescents who use tobacco & cannabis, on the links to other high-risk patterns
Multilevel Correlates of Same Day Poly-Product Use/Co-Use among Adolescents Who Use Tobacco and Cannabis
https://academic.oup.com/ntr/advance-article-abstract/doi/10.1093/ntr/ntaf150/8209432

🧠 The Brain & Neurological Disorders 🧠

In people with drug-resistant epilepsy, there were weakened responses to CBD in people with certain genetic variants of the CYP liver isozymes (that breakdown & clear various drugs from the body)
Analysis of six CYP450 genetic variants regarding the response to cannabidiol combined with anticonvulsant medication in mexican patients with drug-resistant epilepsy
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1626054/full

In human brain scans, THC did not alter levels of glutamate (the brain’s primary excitatory neurotransmitter) in the striatum (a brain area of motor control, learning, reward & motivation)
The Effects of Acute Δ9-Tetrahydrocannabinol on Striatal Glutamatergic Function: A Proton Magnetic Resonance Spectroscopy Study
https://www.biologicalpsychiatrycnni.org/article/S2451-9022(21)00120-8/abstract

For agitation & aggression in Alzheimer's patients, nabiximols (Sativex, a 1:1 THC:CBD spray) were well tolerated
Sativex (nabiximols) for the treatment of Agitation & Aggression in Alzheimer's dementia in UK nursing homes: a randomised, double-blind, placebo-controlled feasibility trial
https://pubmed.ncbi.nlm.nih.gov/40479610/

In the mouse nucleus accumbens (a brain center of reward, motivation & addiction), CBD reduced their locomotor sensitivity to a combination of cocaine & caffeine via modulation of genetic expression
Canabidiol prevents cocaine and caffeine sensitization modulating expression of extracellular matrix genes in the Nucleus Accumbens of male mice
https://www.sciencedirect.com/science/article/pii/S2772392525000252

A proposal to use CRISPR on the ECS for bipolar disorder
Genetic Modulation of Neurotransmitters, Endocannabinoid and Circadian Systems as a CRISPR-Based Personalized Therapy for Bipolar Disorder
https://www.researchgate.net/publication/393792006_Genetic_Modulation_of_Neurotransmitters_Endocannabinoid_and_Circadian_Systems_as_a_CRISPR-Based_Personalized_Therapy_for_Bipolar_Disorder
And OCD
Genetic Modulation of the Endocannabinoid System and Associated Pathways as a CRISPR-Based Personalized Therapy for Obsessive-Compulsive Disorder
https://www.researchgate.net/publication/393792576_Genetic_Modulation_of_the_Endocannabinoid_System_and_Associated_Pathways_as_a_CRISPR-Based_Personalized_Therapy_for_Obsessive-Compulsive_Disorder
And Parkinson’s disease
GENE-PD: A CRISPR-Based Gene Therapy for the Endogenous Modulation of the Endocannabinoid System in Parkinson's Disease
https://www.researchgate.net/publication/393792250_GENE-PD_A_CRISPR-Based_Gene_Therapy_for_the_Endogenous_Modulation_of_the_Endocannabinoid_System_in_Parkinson%27s_Disease
And anxiety
Genetic Modulation of the Endocannabinoid and Stress-Response Systems as a Personalized Therapy for Anxiety Disorders
https://www.researchgate.net/publication/393792920_Genetic_Modulation_of_the_Endocannabinoid_and_Stress-Response_Systems_as_a_Personalized_Therapy_for_Anxiety_Disorders
These are quite out there ideas & they come from someone with an odd list of papers. But I’m a completionist, so here they are.

💭 Mental Health, Addiction & Cannabis Use Disorder 💭

In a genetic analysis of schizophrenia & cannabis use disorder risk, they had overlapping polygenic scores
Investigating the Polygenic Relationship Between Cannabis Use and Schizophrenia in the All of Us Research Program
https://pubmed.ncbi.nlm.nih.gov/40475137/

In Australian cannabis users, those using illicit medical cannabis had a higher rate of cannabis use disorder than those using prescribed medical cannabis
Factors associated with cannabis use disorder among Australians using prescribed and illicitly-sourced medical cannabis
https://www.sciencedirect.com/science/article/pii/S2772724625000459

On screening for cannabis use disorder with the Cannabis Use Disorder Identification Test - Consumption (CUDIT-C)
The Cannabis Use Disorder Identification Test - Consumption (CUDIT-C) as a targeted tool for cannabis use screening
https://pubmed.ncbi.nlm.nih.gov/40499234/

For plant-derived CBD, a Japanese review found low abuse potential
[Low Abuse Potential of Plant-Derived Highly Purified Cannabidiol: A Narrative Review]
https://pubmed.ncbi.nlm.nih.gov/40887246/

In a rat model of schizophrenia, CBD reduced their hyperlocomotion & deficits in the Novel Object Recognition test, with stronger effects in females
Prophylactic efficacy of cannabidiol and sodium nitroprusside in a ketamine-model of schizophrenia: sex-dependent effects on positive-like and cognitive impairments
https://pubmed.ncbi.nlm.nih.gov/40886890/

In a rat model of stress & depression, inhibiting the FAAH enzyme (which breaks down anandamide) caused increased dopamine levels in the striatum (a brain area of motor control, learning, reward & motivation)
The effects of FAAH inhibitor, URB597, on dopamine content, synthesis and degradation in the striatum of the rats exposed to chronic unpredictable stress
https://imagine.imgge.bg.ac.rs/bitstream/handle/123456789/3006/Book%20of%20Abstracts%20BeCELS%20.pdf?sequence=1&isAllowed=y

🧬 Reproduction & Hormones 🧬

In pregnancy, on the factors shaping someone's use of cannabis
Navigating cannabis use during pregnancy: life trajectories, relationships, and contextual influences
https://www.sciencedirect.com/science/article/pii/S1877575625000679

In pregnant women using opioids, they had higher levels of tobacco use across their pregnancy but lower levels of cannabis use
Tobacco and cannabis use among pregnant women with prenatal opioid use
https://www.sciencedirect.com/science/article/pii/S0306460325002035

In the peripartum period (around the birth), a review on the use of cannabis
Cannabis Use in the Peripartum Period
https://www.sciencedirect.com/science/article/abs/pii/S1751485125001497

🦠 The Immune System & Microbial 🦠

On targeting lung bacterial & fungal infections, a thesis project on using a combination of cannabinoids & pentamidine (an antibiotic)
Targeting Pulmonary Bacterial And Fungal Infections With Inhalable Cannabinoids And Pentamidine
https://ses.library.usyd.edu.au/handle/2123/34264

For fibromyalgia, a review on the use of cannabis
THERAPEUTIC USE OF CANNABIS IN FIBROMYALGIA: CURRENT EVIDENCE AND FUTURE PERSPECTIVES
https://asclepiushealthjournal.com/index.php/aijshs/article/view/174

🦴 Pain, Musculoskeletal, Inflammation & Surgeries

For middle-aged or older adults with pain, a survey on how they chose between cannabis and opioids
Exploring pain management preferences: a discrete choice experiment on cannabis or opioids among middle-aged and older adults
https://jhpn.biomedcentral.com/articles/10.1186/s41043-025-00989-x

🍽️ The Guts, Metabolism & the Microbiome 🍽️

In people with severe obesity, a proposal of endocannabinoids as biomarkers of sarcopenic obesity (loss of skeletal muscle mass)
Endocannabinoids as potential biomarkers of sarcopeniac obesity in patients with severe obesity
https://uca.hal.science/hal-05235634/

In stem cells derived from fat cells, CBD promoted their differentiation into fat cells again
Cannabidiol as Modulator of Spontaneous Adipogenesis in Human Adipose-Derived Stem Cells
https://pubmed.ncbi.nlm.nih.gov/40509260/

🩸 The Liver, Drug Interactions & Cannabinoid Metabolism 🩸

The pharmacokinetics of liposomal CBD injection in rabbits & mini pigs
Liposomal-Cannabidiol Injection; Preliminary Insights into Pharmacokinetics and Safety Characteristics in Göttingen Minipigs and Rabbits
https://precisionnanomedicine.com/article/141764-liposomal-cannabidiol-injection-preliminary-insights-into-pharmacokinetics-and-safety-characteristics-in-gottingen-minipigs-and-rabbits

For PEA in rats, a comparison of the pharmacokinetics from micronized & water-dispersible PEA vs standard PEA
Pharmacokinetics of micronized and water dispersible palmitoylethanolamide in comparison with standard palmitoylethanolamide following single oral administration in male Sprague-Dawley rats
https://journals.lww.com/iphr/fulltext/2025/07000/pharmacokinetics_of_micronized_and_water.3.aspx?context=latestarticles

In rats, chronic cannabis smoke was linked to higher weight, higher liver weight & disruptions to the liver
Histomorphology Architecture and Weight Changes Following Long Term Exposure to Marijuana (Cannabis sativa) Smoke on the Liver of Wistar Rats
https://hal.science/hal-05170612/

❤️ The Heart & Blood ❤️

For blood pressure, a review of 14 articles found CBD decreased blood pressure & lessened pressure spikes in stress situations
CANNABIDIOL AND RESISTANT HYPERTENSION: EVIDENCE ON BLOOD PRESSURE MODULATION
https://interferencejournal.emnuvens.com.br/revista/article/view/189

In a mouse model of atherosclerosis (hardened arteries), those with no CB1 receptors had less hardening, with effects greater in females
Endothelial cannabinoid CB1 receptor deficiency reduces arterial inflammation and lipid uptake in response to atheroprone shear stress
https://www.researchsquare.com/article/rs-6944788/v1

💨 The Lungs 💨

In human bronchial epithelial cells (lining of lungs), THC exposure decreased cell viability & altered metabolism & genetic transcription, with the greatest effects on ferroptosis (cell death via iron)
Cellular and Transcriptional Responses of Human Bronchial Epithelial Cells to Delta-9-Tetrahydrocannabinol In Vitro
https://pubmed.ncbi.nlm.nih.gov/40508028/

💧 The Genitourinary System 💧

In people waiting for a kidney transplant, the effects of cannabis are… locked behind a paywall
Association of Cannabis Use With Access to Kidney Transplantation and Post-Transplant Outcomes
https://pubmed.ncbi.nlm.nih.gov/40465402/

In rat kidneys, cannabis caused pigmentations, fibrosis & necrosis
The Histological Effects of Marijuana in the Kidney of Male Wistar Rats
https://www.researchgate.net/publication/393843464_The_Histological_Effects_of_Marijuana_in_the_Kidney_of_Male_Wistar_Rats

🎗️ Cancer & Chemotherapy 🎗️

For people with cancer, on their perceptions & information sources for medical cannabis (with these researchers implying it was stupid to believe in the antitumor efficacy of the cannabinoids, despite the wide swathe of evidence types)
Perceptions, Uses, and Information Sources of Medical Cannabis Among Patients With Cancer
https://www.advancesradonc.org/article/S2452-1094(24)00241-0/fulltext

In oral cancer, a review of CBD synergizing with tyrosine kinase inhibitors
Molecular Crosstalk and Therapeutic Synergy: Tyrosine Kinase Inhibitors and Cannabidiol in Oral Cancer Treatment
https://www.mdpi.com/1467-3045/47/8/584

In cancer cells, a protein breakdown technology to degrade CB1 receptors
Development of PROTAC-Based Strategies for Cannabinoid Receptor Type 1 (CB1R) Degradation in Cancer
https://pubs.acs.org/doi/full/10.1021/acsptsci.5c00321

For melanoma cells, on using nanostructured lipid carriers for the co-delivery of CBD & paclitaxel
Codelivery of Paclitaxel and Cannabidiol in Lipid Nanoparticles Enhances Cytotoxicity against Melanoma Cells
https://pubmed.ncbi.nlm.nih.gov/40488002/

💊 Synthetic Cannabinoids & Hemp-Derived Cannabinoids 💊

In people experiencing homelessness, interviews on the effects of synthetic cannabinoids
An exploration into the use of Synthetic Cannabinoid Receptor Agonists (SCRAs) and their impact on homeless populations health and wellbeing
https://e-space.mmu.ac.uk/641687/

For delta-8-THC, the US laws & usage patterns
U.S. State Marijuana and Delta-8-Tetrahydrocannabinol Laws and Delta-8-Tetrahydrocannabinol Use
https://www.sciencedirect.com/science/article/pii/S0749379725005045

In e-cigarette liquids, on rapid detection of synthetic cannabinoids with miniature ion trap mass spectrometry
Rapid Detection of Synthetic Cannabinoids in E-Cigarette Liquids Based on Miniature Ion Trap Mass Spectrometry
https://zpxb.xml-journal.net/en/article/pdf/preview/10.7538/zpxb.2024.0196.pdf

🔬 Biochemical Discoveries & Research Tools 🔬

On targeting cannabinoid receptors in the body with indazoles (benzene ring + pyrazole ring)
Indazole partial agonists targeting peripheral cannabinoid receptors
https://www.sciencedirect.com/science/article/abs/pii/S0968089625002688

On a biocatalytic method for producing minor cannabinoids
Developing Biocatalysis for Production of Specific Minor Cannabinoids
https://eprints.qut.edu.au/259593/

Thanks.
- lex

PS: For today’s master of all drums, Don Ralke’s landmark jungle exotica album ‘The Savage and The Sensuous Bongos’.

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Cannabinoids & the People