C&P#158: spinal cord injuries, endometriosis, cancer & health sulfur springs treatments
Germany says no new medical imports & Bavaria blocks clubs with building codes
🌟 This week 🌟
Cannabis for spinal cord injuries & endometriosis
Combine hemp with your health spa sulfur spring treatments
CBD topicals for orofacial pain (says 10 studies)
Cannabis for cancer symptoms! (a review of 16 studies) + but does cannabis worsen cancer immunotherapy?
Endocannabinoids in your breast milk
So many studies for growers
Preclinical: CBD for stressed out female rats eating unhealthy food + CBD & CBG for neuropathic pain from chemotherapy + Alzheimer’s (2x)
Harms: dry mouth & driving + (5x) negatives for pregnancy & female fertility
In teens, females now more diagnosed with cannabis use disorder
Posters from Eurotox 2025 (a toxicology conference with a focus this year on cannabinoids)
For honey bees infected by a fungus, give ‘em cannabis!
Psychedelics: ayahuasca for grieving & creativity + LSD for anxiety + psilocybin for PTSD, depression & end-of-life anxiety
Industrial uses: for your steel, cannabis extract to resist corrosion + for your cow manure, hemp for better biofuels + for your heavy-metal contaminated water, hemp to clean it + for your 3D printing, hemp waste
(this week’s numbers: ~13,000 words, ~30 minutes reading time, 291 papers)
Hello everyone,
Welcome to the 158th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news & coverage of psychedelics, the War on Drugs & harm reduction. Support this work sharing canna-science with a paid subscription here. As always, ask me anything.
#FreePalestine
📌 Editor’s notes:
As a lover of books & a respecter of psychedelics, I highly recommend the new book on using psychedelics for sexual trauma by the therapist (& friend of the newsletter) Dee Dee Goldpaugh: ‘Embrace Pleasure: How Psychedelics Can Heal Our Sexuality’. See my impassioned video review here.
Also, thanks to Ben Arn & his team for another great CB Expo. I’ll be doing a LinkedIn roundup once I catch up from being away.
Speaking of, enjoy this double-header newsletter with two weeks of content. It’s a doozy, but filled with goodies.
Finally, if you want to vote for me in the Emjays, the link is here. And you’re allowed to vote once a day.
🤝 Sponsor 🤝: The Cannabis & Health Research Initiative
Want to help expand the knowledge of medical cannabis use in the real world & get paid 100 bucks to do so?
Johns Hopkins University, with support from Realm of Caring, is spearheading the groundbreaking National Cannabis Study to evaluate the benefits, risks & overall outcomes of using cannabis for conditions like pain, insomnia, anxiety & more. If you are an adult in the U.S. considering starting cannabis for health reasons, this is your chance to help shape the future of cannabis research — and get compensated for your time ($100!). Join now to share your experience & contribute valuable data that could revolutionize healthcare for many patients nationwide. To learn more & sign up, visit:
https://ncs.cannabisandhealth.org/
Follow along on Instagram to keep on learning or sign up for the monthly CHRI email (curated by me) to get just the best of clinical research & new reviews each month.
🧰 Free resources 🧰
CVResearch.info: the extensive cannabinoid science archive I maintain for CV Sciences
Canna-edu videos: on YouTube @CVScienceInc & on TikTok @pluscbd (backup account @cannabinoidsandthepeople)
My Free How-To Guides on cannabinoids for different conditions. #AMAMy glossary of cannabinoid terms (& my Neural Ocean metaphor)
And as always, at the bottom is the album of the week: Bechet!
💖 Ways to support this work 💖
A paid subscription on Substack
Buy Me a Coffee
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PayPal: donate here
🐋 For more from Lex… 🐋 | my Linktree |
‘Anandamide; or, the Cannabinoid’: my cannabis graphic novel series (based on Moby Dick):
- ‘SUNset’: Queer canna-history from the AIDS crisis- ‘The CROWN’: the hunt for the chemical structure of CBN, the first fully-solved cannabinoid, as explained through elephants
First 2 seasons of my podcast ‘The Lex Files’ on cannabinoids, psychedelics & spirituality
Work with my company White Whale Creations to produce cannabis content: writing, science archives, social media, newsletters & podcasts: my portfolio
📣 A request to spread the word 📣
This newsletter only spreads by word of mouth,
so please forward to colleagues & tell your friends & relatives.
🎥 My work this week 🎤
Canna-Edu Vids for CV Sciences:
(on YT @CVSciencesInc & on TT @pluscbd)
Cannabis for Degenerative Spine & Joint Diseases (the quite intriguing health spa study)
My 📚 Vids:
(@LexPelgerAndHisBooks on TikTok, YouTube & Instagram)
how I read a book (the video I wish I had when I was 20)
‘Magic & Mystery in Tibet’ by Alexandra David-Neel (this book is a classic for a reason)
Sciencemancy from my Germany trip: Social Interactions & the Brain (the neurodivergents liked this one) + Pathogens of Ancient Humanity + Collective Memory Loss (fish) + Planet Formation & Late Accretions + Esoteric Rose Math
🍃 BEST OF CANNABINOID SCIENCE 🍃
(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)
⚕️ Clinical ⚕️
In people with spinal cord injuries, a survey found that they used cannabis for alleviating pain & improving sleep, with edibles being the most common modality
Understanding Cannabis Use After Spinal Cord Injury: A Canadian Survey Study
https://www.sciencedirect.com/science/article/pii/S2590109525000734
For people with pain from endometriosis, a survey found help for chronic pelvic pain, dysmenorrhea (painful periods), insomnia & nausea, with their preferred ingestion methods being smoking & oils, with evidence for inhalation being the most effective
“A dose of relief?”: Results of an international survey exploring self-reported effectiveness, dose and dosage forms of cannabis for endometriosis pain and related symptoms
https://www.researchsquare.com/article/rs-6910005/v1
In a unique study from a health spa using healing waters for people with degenerative spine & joint diseases, adding CBD massages & hemp infusions to the treatment helped more with their pain
Cannabis therapy for pain management in degenerative diseases – implementation of R&D results in health resort. A case study and best practices
https://actabalneologica.pl/wp-content/uploads/library/ActaBalneol2025i4.pdf#page=21
On cannabis & sleep architecture, a meta-analysis of 9 studies
Cannabis and sleep architecture: A systematic review and meta-analysis
https://www.sciencedirect.com/science/article/pii/S1087079225001170
“Findings indicate that cannabis administration does not consistently alter sleep duration, latency, wake time, efficiency, or sleep staging. While early studies suggested reductions in rapid eye movement sleep, these were primarily based on small-scale trials with high tetrahydrocannabinol doses and significant methodological limitations. More recent studies using larger samples and lower therapeutic doses of tetrahydrocannabinol have reported mixed (and often no) evidence of rapid eye movement (REM) suppression, and the evidence base remains very limited. However, withdrawal from active cannabis use was consistently associated with sleep disturbances, including reduced total sleeping times and prolonged sleep onset latency, as well as REM rebounds.”
For the mental health uses of cannabis, a survey of older Canadians found the majority thought cannabis somewhat or extremely helpful in managing their symptoms
Characterization of the Use and Perceptions of Cannabis for Mental Health in Older Canadians: A Cross-Sectional Analysis
https://journals.sagepub.com/doi/pdf/10.1177/30495334251347034
In underrepresented groups experiencing discrimination, CBD was helpful in reducing negative emotional symptoms in the short term without increasing risk for disordered alcohol use
Effects of Cannabinoids on Emotional States and Alcohol Use Among Underrepresented Groups: Moderation by Perceived Discrimination
https://pubmed.ncbi.nlm.nih.gov/40916181/
In people undergoing total knee replacement, those who received 400 milligrams of CBD had lower opioid requirements & pain scores, while 800 mg caused more CBD side effects
OP60 Effects of cannabidiol (CBD) oral solution in patients undergoing bilateral total knee arthroplasty: a randomized, controlled, parallel, triple blind, pilot study
https://rapm.bmj.com/content/50/Suppl_1/A38.abstract
In children with treatment-resistant epilepsies, CBD reduced their seizures & improved other symptoms with a strong retention rate over 18 months
Assessing Real World Efficacy, Safety, and 18‐Month Retention Rates of Cannabidiol in Individuals With Drug Resistant Epilepsies
https://onlinelibrary.wiley.com/doi/pdf/10.1111/ene.70304
In children with drug-resistant epilepsy taking Epidyolex (pharmaceutical CBD isolate), a long-term blood analysis found consistently undetectable levels of THC
Long-term plasma monitoring of THC and CBD in pediatric drug-resistant epilepsy: Implications for cannabidiol therapy with Epidyolex®
https://pubmed.ncbi.nlm.nih.gov/40938500/
This is important because there is a constant fear that the liver might be converting CBD to THC. This can be seen to happen in liver simulations, but it seems unlikely, from the handful of studies we have, that this is happening in the real world.
In older people with poor appetites, an analysis of the large variability in their oral absorption of THC
Population pharmacokinetic modelling revealed large variability in oromucosal absorption of Δ9‐tetrahydrocannabinol in older patients with poor appetite
https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1002/bcp.70284
For caffeine in humans, co-administration with THC had little effect, but adding CBD & THC increased abuse liability & performance impairment
Effect of caffeine and cannabidiol (CBD) co-administration on Δ9-tetrahydrocannabinol (Δ9-THC) subjective effects, performance impairment, and pharmacokinetics
https://www.nature.com/articles/s41386-025-02232-x
In female university students, six weeks of PEA enhanced physiological resilience to stress as indicated by improved heart rate variability
The effects of formulated palmitoylethanolamide supplementation on indicators of stress and heart rate variability in female university students: a randomised crossover trial
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1586409/abstract
In Tunisian males, the cannabis users had better sexual scores
Cannabis use and male sexuality in a Tunisian sample: A case-control study
https://www.sciencedirect.com/science/article/abs/pii/S0013700625001496
A case report of a young girl with Lennox-Gastaut Syndrome (a severe childhood epilepsy) helped greatly by a 20:1 CBD:THC formula
Management of Lennox-Gastaut Syndrome with a CBD/THC Isolate Combination
https://ijclinmedcasereports.com/pdf/IJCMCR-CR-01331.pdf
On using pupils to detect cannabis inebriation, this study confirmed that the changes were not substantial & consistent enough to be used for law enforcement
Pupillary dynamics as a marker of acute cannabis inhalation
https://www.tandfonline.com/doi/abs/10.1080/15563650.2025.2543066
In cat models of fear, CBD (as well as gabapentin & synthetic facial pheromone) altered their physiological responses
Infrared Thermography and Physiological Variables as Methods for Recognizing Fear in Domestic Cats (Felis catus) Using Three Pharmacological Models: Cannabidiol, Gabapentin, and Synthetic Facial Pheromones
https://pubmed.ncbi.nlm.nih.gov/40559760/
📑 Reviews 📑
A review of the potential of cannabis for global health (nice charts)
From farm to bedside: Potential of medical cannabis in global health
https://www.sciencedirect.com/science/article/pii/S0965229925000809
In people with cancer, this review of 16 studies suggested that medical cannabis increased survival time, improved cognitive function, mental health, sleep, appetite & pain as well as decreased nausea, vomiting & the use of other medications such as opioids
Impact of Medical Cannabis on the Quality of Life of Cancer Patients: A Critical Review
https://www.liebertpub.com/doi/abs/10.1177/27683605251377417
In human milk, an analysis of metabolites & how the endocannabinoids are associated with improved neonatal sucking
CHARACTERIZATION OF OMICS COMPONENTS IN HUMAN MILK: A SYSTEMATIC REVIEW
https://sciendo.com/fr/article/10.34763/jmotherandchild.20252901.d-24-00044
In sickle cell disease, a review of 12 papers on cannabinoids
Cannabis Use for Chronic Pain in Sickle Cell Disease: A Scoping Review
https://www.sciencedirect.com/science/article/abs/pii/S1524904225002012
For orofacial pain, a review of 10 CBD studies found it caused painkilling, anti-inflammatory & muscle-relaxant effects as well as helping with bruxism (teeth grinding) when applied topically
Cannabidiol for Orofacial and Upper-Quarter Pain: A Systematic Evaluation of Therapeutic Potential
https://pubmed.ncbi.nlm.nih.gov/40565932/
For chronic pain, a review on the clinical effects & legal barriers of cannabinoids (nice charts)
Cannabinoids in Chronic Pain: Clinical Outcomes, Adverse Effects and Legal Challenges
https://www.mdpi.com/2035-8377/17/9/141
And for lower back pain, a thesis project on the involvement of the endocannabinoid system
An investigation of the endocannabinoid system in low back pain
https://researchrepository.universityofgalway.ie/entities/publication/3e11acc3-0a49-450a-9468-6dffb893d57c
For anxiety-related disorders from a number of causes, a review on the effects of CBD & THC
Effects of Different Cannabinoid Formulations on Anxiety-Related Disorders, and Tourette Syndrome: A Systematic Review and Meta-Analysis
https://www.liebertpub.com/doi/abs/10.1177/25785125251378242
“Low-quality evidence suggests that pharmaceutical-grade CBD may have limited efficacy for SAD [social anxiety disorder] and GAD [generalized anxiety disorder]. In addition, low-quality evidence supports Δ9-THC’s efficacy for the reduction of nightmares in PTSD and tic severity in TS [Tourette syndrome ].”
A review of cannabis for depression, anxiety, PTSD, sleep & cognition
246: Cannabis and Depression, Anxiety, PTSD, Sleep, and Cognitive Function Update and Review
https://static1.squarespace.com/static/5ef3b2b2b1eee677b315048f/t/68b1f2ef5bff4e5c8b08e44c/1756492527272/246_Puder_Cannabis+and+Depression%2C+Anxiety%2C+PTSD%2C+Sleep%2C+and+Cognitive+Function+Update+and+Review.pdf
For inflammatory bowel disease, a review on the links between the gut microbiome & the endocannabinoid system
The Intestinal Microbiota: An Environmental Effector for the Endocannabinoid System and Medicinal Cannabis in Inflammatory Bowel Disease
https://www.researchgate.net/publication/395665263_The_Intestinal_Microbiota_An_Environmental_Effector_for_the_Endocannabinoid_System_and_Medicinal_Cannabis_in_Inflammatory_Bowel_Disease
For epilepsy, a review on CBD’s efficacy based on EEG recordings
Analysis of the cannabidiol effects in epilepsy treatment based on seizure characteristics in EEG recordings – A review
https://onlinelibrary.wiley.com/doi/abs/10.1002/epd2.70085
For wound healing, a review of the evidence for cannabis
Role of Cannabis sativa on wound healing: An update
https://www.researchgate.net/publication/395380714_Role_of_Cannabis_sativa_on_wound_healing_An_update
For bacterial infections & iron metabolism, a review of how the endocannabinoid system modulates iron levels & the effects on bacterial growth
Interactions Between Iron Metabolism and the Endocannabinoid System in Bacterial Infections
https://pubmed.ncbi.nlm.nih.gov/40558204/
In PTSD, a review of the role of endocannabinoids
Understanding the Role of Endocannabinoids in Posttraumatic Stress Disorder
https://pubmed.ncbi.nlm.nih.gov/40564991/
In periodontitis (severe gum infection), a review on the levels of endocannabinoids & the potential of targeting the CB2 receptor
Endocannabinoid system in periodontitis: A systematic review and in silico analyses
https://www.sciencedirect.com/science/article/abs/pii/S0003996925002225
In sepsis (an inflammatory reaction to infection), a review of pre-clinical research of the cannabinoids for improved survival as well as reduced inflammation, & organ injury
Cannabinoids in preclinical research of sepsis: a scoping review
https://pubmed.ncbi.nlm.nih.gov/40956450/
For behavior & stress, a review of the neural circuits involving the endocannabinoid system
Circuit mechanisms governing endocannabinoid modulation of affective behaviour and stress adaptation
https://pubmed.ncbi.nlm.nih.gov/40935953/
For cannabis polysaccharides, a review of their “remarkable” antioxidant & anti-aging activity
Cannabis polysaccharides (CPs): Extraction methods, structural characteristics, biological activities and structure-function relationship: A review
https://www.sciencedirect.com/science/article/abs/pii/S0141813025083278
For cats, a review of the limited studies
Cats and cannabinoids: past, present and future
https://journals.sagepub.com/doi/pdf/10.1177/1098612X251365392
⚠️ Harms ⚠️
On the allergen profile of cannabis
Molecular characterization of sensitization profiles of Cannabis sativa
https://www.tandfonline.com/doi/full/10.1080/14737159.2025.2562869
For in utero cannabis exposure, a review of 19 papers on the effects
The consequences of in utero cannabis exposure within the neonatal period: A scoping review of literature
https://search.informit.org/doi/abs/10.3316/informit.T2025090900002201860181291
And in pregnancy public health data, chronic prenatal cannabis exposure was associated with lower total brain volume in the first month of postnatal life
In utero chronic cannabis exposure is associated with lower total brain volume in the first month of postnatal life
https://www.tandfonline.com/doi/full/10.1080/00952990.2025.2506112
And in female fertility, THC was linked to lower rates of embryos with the correct number of chromosomes & more eggs with chromosome segregation errors & abnormal spindle morphology
Cannabis impacts female fertility as evidenced by an in vitro investigation and a case-control study
https://www.nature.com/articles/s41467-025-63011-2
And in a mouse model of maternal stress & prenatal THC exposure, the mothers showed impaired maternal behavior & in adolescence, the pups had gender specific behavioral alterations
Concurrent maternal stress and THC exposure during pregnancy alters adolescent behavioral outcomes and corticolimbic molecular programs
https://www.researchsquare.com/article/rs-7031901/v1
And in a model of the placenta, cannabis smoke altered the oxidative stress response & inflammatory gene expression
Cannabis Smoke Extract Disrupts Trophoblast Differentiation and Causes Mitochondrial Dysfunction Beyond the Effects Of Δ9-THC Alone
https://www.researchsquare.com/article/rs-7546936/v1
For cancer & immunotherapy, this review charges that cannabinoids are causing lowered response rates & reduced survival because of their ability to dampen the immune response
Are cannabinoids with cancer immunotherapy contributing to early death? A call for caution and further study
https://pubmed.ncbi.nlm.nih.gov/40706038/
I think that this makes a lot of sense based on what we know about how immunotherapy & the cannabinoids work. If I knew someone diagnosed with cancer, I would recommend that they do two weeks of huge doses under a cannabis healthcare professional & then go about their regular cancer treatments. But I wouldn’t combine them unless you really needed symptom relief from the traditional treatment. And even then, keep the levels of use as low as you can.
For surgery, a meta-analysis of 8 studies found cannabis use associated with an increased risk of heart attacks, neurological complications, kidney complications & slightly longer length of hospital stay
Effect of Cannabis Use on Perioperative Outcomes: A Systematic Review and Meta-Analysis of Propensity Score-Matched Studies
https://www.sciencedirect.com/science/article/abs/pii/S0002870325002261
For dentistry, a Canadian survey found potential associations of cannabis use with dry mouth, cavities, harm to oral tissue & increased oral lesions
Oral Health in the Age of Cannabis: Pharmacology, Implications and Dental Management
https://jcda.ca/p12
For xerostomia (dry mouth), public health linked it to the use of cigarettes, e-cigarettes or cannabis
Associations of Current Cigarette, E-Cigarette, and Cannabis Use with Xerostomia
https://journals.sagepub.com/doi/abs/10.1177/23800844251364158
For first-episode psychosis & cannabis use, the suicide risk was increased during “several distinct high-risk periods: pre-treatment untreated psychosis, the first month after treatment initiation, post-discharge transitions, and periods of cannabis use pattern changes”
High-Risk Periods and Opportunity Windows in First-Episode Psychosis, Cannabis Use, and Suicide Risk: A Narrative Systematic Review
https://link.springer.com/article/10.1007/s11469-025-01550-x
In psychosis from synthetic cannabinoids, a review of 35 studies on treatment strategies
Clinical Management of Synthetic-Cannabinoid-Induced Psychosis: A Systematic Review of Treatment Strategies and Outcomes
https://www.mdpi.com/2076-3425/15/9/1006
For teens with bipolar disorder, a review suggested that cannabis may represent a precipitating agent (cause)
Adolescent cannabis use and onset of bipolar disorder: gaining causal clarity by viewing the evidence through the Bradford Hill lens
https://pubmed.ncbi.nlm.nih.gov/40534313/
In people with cannabis use disorder as well as another substance use disorder (or two), they were more likely to have personality or mood disorders as well as to have experienced more severe childhood maltreatment than people with cannabis use disorder alone
Polysubstance Use Disorders in Individuals with Cannabis Use Disorder: Results from a Nationally Representative Sample (National Epidemiologic Survey on Alcohol and Related Conditions)
https://www.liebertpub.com/doi/full/10.1177/25785125251363122
In young adult & minority populations, there’s been a rising prevalence of cannabinoid hyperemesis syndrome
Increasing Prevalence of Cannabinoid Hyperemesis Syndrome in Young Adults and Minority Populations
https://pubmed.ncbi.nlm.nih.gov/40511929/
For adolescents with cannabinoid hyperemesis syndrome, a case report of two adolescents helped by aprepitant (a drug for nausea & vomiting)
Cannabinoid Hyperemesis Syndrome in Adolescents: The Role of Aprepitant as a New Treatment Option for Rapid Symptom Relief
https://www.jahonline.org/article/S1054-139X(25)00366-0/pdf
For cannabis use disorder among young people, public health data showed that female diagnoses have now surpassed male diagnoses
Narrowing and Reversing Sex Gaps in Cannabis Use and Cannabis Use Disorder Among Adolescents and Young Adults
https://www.jsad.com/doi/abs/10.15288/jsad.25-00092
A case report of cannabinoid hyperemesis syndrome leading to severe abdominal pain & profound lactic acidosis due to severe dehydration
Cannabinoid Hyperemesis Syndrome: A Rare Cause of Severe Abdominal Pain and Hyperlactataemia
https://assets.cureus.com/uploads/case_report/pdf/403795/20250916-289448-sdi166.pdf
A case report where cannabinoid hyperemesis syndrome led to pneumomediastinum (air in the chest cavity) via the Macklin effect (“air dissection along bronchovascular sheaths following alveolar injury”)
Imaging the Invisible: The Macklin Effect in Cannabinoid Hyperemesis Syndrome
https://www.acpjournals.org/doi/full/10.7326/aimcc.2025.0598
A case report of a young person with psychosis & catatonia, perhaps exacerbated by cannabis use
Cannabis Use and Neuropsychiatric Decompensation in Adolescence: A Case of Catatonia and Psychosis
https://www.liebertpub.com/doi/abs/10.1177/10445463251379794
In people who were using cannabis before their trauma, they were more likely to have higher scores of post-traumatic stress symptoms
Pre-Trauma THC Use Is Associated With a Positive Posttraumatic Adjustment Scale Screening
https://journals.sagepub.com/doi/abs/10.1177/00031348251381622
One might also argue that they were using cannabis because they were already more vulnerable to trauma, leading to more post-traumatic stress symptoms.
In patients of the Veterans Health Administration, cannabis liberalization laws were associated with an increased prevalence of cannabis use disorder
Cannabis Legalization and Cannabis Use Disorder by Sex in Veterans Health Administration Patients, 2005–2019
https://www.tandfonline.com/doi/abs/10.1080/10826084.2025.2554866
For cannabis use disorder, a review of pharmacological treatments
Emerging pharmacological strategies for the treatment of cannabis use disorder
https://www.tandfonline.com/doi/full/10.1080/14656566.2025.2558999
In a driving simulator study, THC increased the number of car crashes & levels of sleepiness for up to 4 hours & surprisingly, there were no difference between chronic & naïve users & the blood levels of THC did not coincide with the time of highest car crash risk (5 to 15 minutes after smoking)
Understanding cannabis use and car crashes: Insights from a randomized trial using a driving simulator on THC blood levels and subjective measures of sleepiness and performance
https://www.sciencedirect.com/science/article/pii/S0022437525001367
For driving safety from public health data, there was a consistent but lagged pattern of increased fatality rates in several states after cannabis legalization
Evaluation of the causal impact of recreational marijuana legalisation on traffic safety in the US
https://pubmed.ncbi.nlm.nih.gov/40543499/
But in simulated driving performance, cannabis users who were not currently high had no driving differences from nonusers
Short-term residual effects of smoked cannabis on simulated driving performance
https://link.springer.com/article/10.1007/s00213-025-06880-1
For cannabis & heart health, a review suggesting that it should be screened for in cardiovascular risk assessments
Marijuana and Peripheral Vascular Disease: Pathophysiology, Clinical Evidence, and Cardiovascular Implications
https://journals.lww.com/cardiologyinreview/abstract/9900/marijuana_and_peripheral_vascular_disease_.607.aspx
For lung cancer, a review on the risks of cannabis smoking
Cannabis use and its impact on respiratory physiology and lung cancer risk: Mechanistic and epidemiological insights (Review)
https://www.spandidos-publications.com/10.3892/br.2025.2058
In adults using cannabis, they had lower levels of α-Klotho (a protein associated with longevity)
Current marijuana use is associated with lower circulating α-Klotho levels in US adults even after adjusting for tobacco use: A national cross-sectional analysis of NHANES
https://pubmed.ncbi.nlm.nih.gov/40718136/
For medical cannabis patients & contaminated cannabis, interviews on their knowledge & experiences
MEDICAL PATIENTS’ AWARENESS, PERSPECTIVES, AND EXPERIENCES WITH CONTAMINATED CANNABIS
https://karger.com/mca/article-pdf/doi/10.1159/000546398/4433272/000546398.pdf
In young people after ACL surgery, cannabis use was associated with higher rates of overnight admission for pain & prolonged time to return to sports
Effect of Marijuana Use on Pain Management and Return to Sport After Anterior Cruciate Ligament Reconstruction in Pediatric and Adolescent Patients: A Matched Control Study
https://journals.sagepub.com/doi/pdf/10.1177/23259671251369015
In adolescent rats with prenatal THC exposure, they had lower levels of dopamine receptors in their prefrontal cortex, especially the D2 receptor in males, which led to changes in pyramidal neuronal excitability & alterations to the Netrin-1/DCC guidance cue system (which guides neurons in their development)
Prenatal Delta-9-Tetrahydrocannabinol Exposure Induces Transcriptional Alterations in Dopaminergic System with Associated Electrophysiological Dysregulation in the Prefrontal Cortex of Adolescent Rats
https://pubmed.ncbi.nlm.nih.gov/40558531/
In podocytes (kidney cells that filter blood), CBD altered their handling of calcium, impaired their mitochondria (powerhouse of the cell) & at high doses, led to cell injury & death
The effects of Cannabidiol on podocytes in vitro
https://www.sciencedirect.com/science/article/pii/S0006291X25013701
🐁 Preclinical 🐁
In a mouse model of obesity, both CBD & THC-rich extracts lowered insulin resistance & fatty liver (aka metabolic dysfunction-associated steatohepatitis (MASH))
Cannabis Improves Metabolic Dysfunction and Macrophage Signatures in Obese Mice
https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00503.2025
In a mouse model of obesity, hemp seeds reduced abdominal size, lowered body weight gain & improved triglyceride & cholesterol levels
Anti-obesity effect of unsaponifiable matter from hemp seed in 3T3-L1 adipocytes and high-fat diet-induced obese mice
https://pubs.rsc.org/en/content/articlelanding/2025/fo/d5fo02231b/unauth
In female rats with a high-fat diet & unpredictable chronic mild stress, CBD promoted coping behavior, increased locomotion, reduced freezing & less depressive-like behavior as well as changes to neuroinflammatory factors
Cannabidiol Effects on Depressive-like Behavior and Neuroinflammation in Female Rats Exposed to High-Fat Diet and Unpredictable Chronic Mild Stress
https://pubmed.ncbi.nlm.nih.gov/40558565/
In rhesus monkeys & rabbits, on the pharmacokinetics of how CBD moves through their system (surprisingly, the rabbits better matched humans than the monkeys did)
Pharmacokinetics of cannabidiol and its metabolites in rhesus monkeys and New Zealand white rabbits
https://academic.oup.com/toxsci/advance-article-abstract/doi/10.1093/toxsci/kfaf129/8257813
In mice vaporizing cannabis, on the influence of their gender, age & the carrier oil
Influence of Carrier Oil, Sex, and Age on Pharmacokinetic and Acute Behavioral Effects of Vaporized Cannabis Extract in Mice
https://www.liebertpub.com/doi/pdf/10.1177/25785125251372062
In a mouse model of pain from fibromyalgia, electroacupuncture helped via increasing the levels of CB1 receptors
Chemogenetic Modulation of Electroacupuncture Analgesia in a Mouse Intermittent Cold Stress-Induced Fibromyalgia Model by Activating Cerebellum Cannabinoid Receptor 1 Expression and Signaling
https://www.mdpi.com/2075-1729/15/9/1458
In mice with no cannabinoid receptors, they were more susceptible to Salmonella bacteria
Deficiency of cannabinoid receptors enhances host susceptibility to bacterial infection
https://journals.asm.org/doi/pdf/10.1128/mbio.02088-25
In a rat model of chronic unpredictable stress, inhibiting the FAAH enzyme (which breaks down anandamide) protected them from the loss of dopamine levels
The effects of FAAH inhibitor, URB597, on dopamine content, synthesis and degradation in the striatum of the rats exposed to chronic unpredictable stress
https://imagine.imgge.bg.ac.rs/bitstream/handle/123456789/3007/Book%20of%20Abstracts%20BeCELS%20_1-9%2C11%2C42-45.pdf
In a rat model of Alzheimer’s disease & neuropathic pain, a cannabis extract improved their mechanical & thermal sensitivity as well as cognitive functions
EP062 Therapeutic potential of an EU-GMP certified cannabis sativa L. in neuropathic pain concurrent with alzheimer’s disease: preclinical insights
https://rapm.bmj.com/content/50/Suppl_1/A85.1.abstract
In a mouse model of Alzheimer’s, CBD improved their short-term memory, reduced alpha-beta plaque accumulation, lessened oxidative damage & decreased activation of the microglia (guardian immune cells of the brain)
Cannabidiol improves short-term memory in a Streptozotocin-induced animal model of Alzheimer’s disease
https://www.researchsquare.com/article/rs-7197783/v1
In a rat model of empathic pain (feeling pain at the sight of someone else feeling pain), the pain levels were decreased by a drug that blocked the CB1 receptor, indicating that the receptor plays a modulatory role in social contagion
Modulatory Effects of CB1 Receptors on Cognitive Performance in Rat Model of Empathic Pain
https://bcn.iums.ac.ir/files/site1/user_files_c424bc/eng/drghazvini-A-10-2297-2-fc2837a.pdf
In a female mouse model of peripheral neuropathy from chemotherapy, a thesis project found that CBD, CBG & mitragynine (from kratom) reduced neuropathic sensitivity
The Use of Preventative Cannabidiol, Cannabigerol, and Mitragynine to Ameliorate Mechanical Sensitivity of Paclitaxel-Induced Peripheral Neuropathy in Female Mice
https://www.proquest.com/openview/4a4a34cd3071990cf073c6992245553d/1
In a rat model of drug-resistant epilepsy, CBD combined well with GABA-targeted drugs but not sodium channel blockers
Cannabidiol combined with GABAergic drugs but not with sodium channel blockers prevents the development of drug-resistance seizures in a preclinical model
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1644018/abstract
In neuronal cells, CBN altered stress response & neuroplasticity without impacting cell viability, suggesting promise for neurodegenerative diseases
Cannabinol’s Modulation of Genes Involved in Oxidative Stress Response and Neuronal Plasticity: A Transcriptomic Analysis
https://pubmed.ncbi.nlm.nih.gov/40563376/
In canine stem cells for regenerative medicine, priming them with CBD-rich extracts increased the activity of genes linked to tissue repair & the reduction of inflammatory cytokines
Priming Canine Adipose Tissue-Derived Mesenchymal Stem Cells with CBDRich Cannabis Extract Modulates Neurotrophic Factors Expression Profile
https://www.preprints.org/frontend/manuscript/06002d015eaafcc44f7489d5f7200d68/download_pub
In Thai cannabis sugar leaves, their extract inhibited a number of pathogenic bacteria
In vitro antimicrobial activity of Thai stick cannabis Hang Kra Rog Phu Phan (Cannabis sativa L.), sugar leaves extract against pathogenic bacteria
https://pubmed.ncbi.nlm.nih.gov/40568500/
On stereoselective synthesis of CBD (different “handedness” of the molecule) & the different effects on memory & anxiety
Stereoselective Synthesis of Cannabidiol and its Unnatural Enantiomer to Evaluate Anxiolytic-Like Properties and Memory Interactions
https://pubmed.ncbi.nlm.nih.gov/40704398/
🆕 Novel Studies 🆕
(my grab bag section for stuff I haven’t quite seen before)
For the odors of hemp, an analysis of their odorant composition
The Plant of Many Scents: Unraveling the Odorant Composition of Selected CBD Hemp Cultivars
https://pubs.acs.org/doi/full/10.1021/acs.jafc.5c07208
And for terpenes, an analysis of their emission profiles across the stages of cannabis growth
Following the smell: terpene emission profiles through the cannabis life-cycle
https://pubmed.ncbi.nlm.nih.gov/40528799/
On the Big Five personality traits, neuroticism was linked to more use of cannabis as well as alcohol & polysubstance use
Predicting Substance Abuse Behaviors: The Role of Big Five Personality Traits and Age in Alcohol, Marijuana, and Polysubstance Use
https://ijip.co.in/index.php/ijip/article/view/9384
To improve the efficacy of the rabies vaccine in mice & humans, the addition of dietary arachidonic acid (a precursor to anandamide) enhanced antibody-mediated immune responses
Dietary supplementation of arachidonic acid promotes humoral immunity
https://www.embopress.org/doi/pdf/10.1038/s44321-025-00310-7
As someone who grew up watching the film ‘Old Yeller,’ this one is close to my heart.
In honey bees infected by a fungus (Nosema (= Vairimorpha) ceranae), cannabis decreased fungal spore counts & increased their survival time
Impact of Cannabis sativa (L.) inflorescences on the control of artificial Nosema (= Vairimorpha) ceranae infection in honey bees Apis mellifera ligustica (Spinola, 1806)
https://link.springer.com/article/10.1007/s13592-025-01216-6
On using smartphone data & AI to analyze whether someone’s gait is due to consuming alcohol or cannabis
Discriminating between Marijuana and Alcohol Gait Impairments using Tile CNN with TICA Pooling
https://ieeexplore.ieee.org/abstract/document/11153826
OK. That’s a bit of a fascinating problem. Is it the Drunkard’s Walk or the Stoner’s Stroll?
📰 US Headlines & Fav Articles 📰
Edible Arrangements expanding its cannabis deliveries to 30 US states
https://www.marijuanamoment.net/company-behind-edible-arrangements-expands-cannabis-deliveries-across-30-states-after-successful-launch-in-texas/
Minnesota’s launch of adult-use cannabis highlighted the market inefficiencies of federal prohibition, with prices 400% higher than right across the border in Michigan where they’re burning plants that aren’t worth the money to process
https://b105country.com/minnesota-michigan-marijuana-prices/
In Colorado, cannabis prices at an all-time low of $649 per pound, despite 25% fewer cultivators, while total sales have decreased 36% since 2021
https://www.westword.com/news/colorado-marijuana-prices-keep-falling-tie-record-low-40785823/
Ongoing strikes in Michigan & Pennsylvania now the longest work stoppages in the industry at 13 days
https://mjbizdaily.com/ongoing-cannabis-worker-strikes-in-two-states-are-longest-in-industry-history/
In Oklahoma, excellent reporting on how cannabis legalization went wrong in their once booming medical cannabis market
https://www.politico.com/news/magazine/2025/09/16/oklahoma-marijuana-industry-00544001
At Disney World, the first non-alcoholic pairing event includes botanicals, hemp, adaptogens & nootropics
https://worldofwalt.com/enzos-non-alcoholic-pairing-event.html
That’s all the kind of weak low-level kind of psychoactives that doesn’t really get you high, but hey, that’s a pretty good start for the House of Mouse.
For the Richardson & Griner cannabis athletics controversies, a TikTok discourse analysis on the intersecting race & gender narratives
An Intersectional Analysis of TikTok Users’ Framing of Sha’Carri Richardson and Brittney Griner During Related Controversies
https://journals.sagepub.com/doi/abs/10.1177/00219347251368936
1979: Willie Nelson smokes a joint on the roof of the White House with Jimmy Carter’s son
https://www.youtube.com/watch?v=5KWh2f-JCyE
And in honor of the Red Headed Stranger, here’s the album that was in the truck I inherited from my grandfather: ‘Stardust’
🌐 International Updates 🌐
UNESCO’s flagship cultural policy conference will have 2 official contributions on cannabis
https://businessofcannabis.com/unescos-mondiacult-to-spotlight-cannabis-in-global-cultural-policy-for-first-time/
In Germany, no new medical cannabis import permits for 2025 (with Canada being the main foreign source)
https://stratcann.com/news/germany-no-new-import-permits-for-dried-cannabis-in-2025/
And teen use is down after recreational legalization
https://www.marijuanamoment.net/teen-marijuana-use-in-germany-declined-following-recreational-legalization-government-study-shows/
And In Bavaria, Germany, building codes used to effectively block social clubs
https://businessofcannabis.com/licences-without-land-cannabis-social-clubs-effectively-blocked-in-bavaria/
In Barcelona, tourist money is starting to alter the cannabis club scene
https://hightimes.com/dispensaries/cannabis-clubs-vs-gentrification-when-tourists-take-over-barcelona/
In the Netherlands, the country’s largest cannabis farm was told to reduce its smell within the week or close
https://edition.cnn.com/2025/09/11/europe/cannabis-farm-netherlands-odor-intl-scli
In Argentina, eco-tourism of a cannabis grow & lab
https://canamo.net/noticias/mundo/integran-ecoturismo-y-ciencia-cannabica-en-la-montana-argentina
On Chicanx communities’ & cannabis relationships
Chicanx Cannabis Relationships
https://elibrary.ru/item.asp?id=81663494
In Australian medical cannabis consumers, an analysis of their motivations & accessibility
Motivations and Pathways: A Thematic Analysis of Interviews with Medicinal Cannabis Consumers in Australia
https://www.tandfonline.com/doi/pdf/10.1080/10826084.2025.2560074
Here in France, an analysis of who is growing their cannabis at home
Home Cultivation of Cannabis in a Context of Prohibition: Results from Two Online Cross-Sectional Surveys of People Using Cannabis Daily in France
https://www.mdpi.com/1660-4601/22/8/1167
In Thailand, a survey on the characteristics & frequency of people who use cannabis
Characteristics and Frequency of Use of People Who Use Cannabis in Thailand: Results From a Web-Based Survey
https://animorepository.dlsu.edu.ph/cgi/viewcontent.cgi?article=1582&context=apssr
In South Africa & Zimbabwe, a comparison of their cannabis trajectories
Comparative Analysis of Cannabis Legalization in South Africa and Zimbabwe: Trajectories, Commonalities, and Divergences
https://jied.lse.ac.uk/articles/10.31389/jied.283
⚖️ Business, Laws & Education ⚖️
Trumps tariff’s hit India, the world’s largest supplier of pre-rolled cones, one of the fastest-growing segments in the cannabis industry
https://mjbizdaily.com/trumps-india-tariffs-threaten-cannabis-industrys-fastest-growing-segment/
For banking, a federal report found banks peaked at working with cannabis businesses in 2018 & it’s been a steady 800+ banks since then
https://www.marijuanamoment.net/federal-agency-issues-update-on-marijuana-banking-trends-as-trump-weighs-rescheduling/
For taxes, cannabis industry group NCIA is pushing for retroactive relief from 280E with a report for Congress highlighting their effective 70% taxation
https://www.marijuanamoment.net/marijuana-industry-group-pushes-congress-for-tax-relief-and-to-apply-the-fix-retroactively-for-past-payments/
For Colorado nonprofits, interviews on whether they would accept cannabis industry philanthropy
Accept or Reject: Factors Influencing Nonprofit Responses to Cannabis Industry Philanthropy
https://onlinelibrary.wiley.com/doi/abs/10.1002/nvsm.70032
For cannabis product labeling, on the perception effects about safety & benefits
Cannabinoid content on product labels influences cannabis health perceptions
https://pubmed.ncbi.nlm.nih.gov/40553093/
On cannabis product warning labels, interviews on how people responded
Assessing Responses to Cannabis Health Warnings Among Adults in U.S. Recreational States
https://www.sciencedirect.com/science/article/abs/pii/S0749379725004891
For collegiate student-athletes, a survey of their views on opportunities in the cannabinoid industry for licensing their name, image & likeness
Exploring Student-Athlete Perceptions on NIL Opportunities in the Cannabinoid Industry
https://www.proquest.com/openview/3565f28d88978f28b91d8c571ff062a7/1
For US cannabis business owners, a thesis project interviewing them about their regulatory restrictions
Navigating the Hazy Path: Analyzing the Impact of Regulatory Restrictions on Cannabis Business Owners in the United States
https://www.proquest.com/openview/3e96652d95184f968bf166d5430661f4/1
🚓 The War on Drugs 🚓
For regulating drug precursors, a review of the effects on the illicit drug market
Does Regulating Drug Precursors Affect Illicit Drug Markets? An Expanded and Updated Systematic Review
https://www.sciencedirect.com/science/article/pii/S0376871625003539
Cannabis
In Australia, defendants who receive a warning for their cannabis use were 16% less likely to re-offend than those who were prosecuted
Does diverting minor drug offenders reduce recidivism? Cannabis cautioning in Australia
https://www.sciencedirect.com/science/article/pii/S0955395925003044
In decriminalization in New York City, Los Angeles & Chicago, there were significantly less cannabis possession arrests & a narrowing of the racial disparities in arrest
Cannabis deregulation and policing
https://www.sciencedirect.com/science/article/abs/pii/S016726812500321X
For young adults with a cannabis criminal record, a legal analysis of criminal record relief & its challenges
The Intersection of Cannabis Legalization, Criminal Record Relief, and Emerging Adulthood
https://kb.osu.edu/server/api/core/bitstreams/8e87b1f4-420d-476d-b1f5-3e22d1df5c4f/content
In Arizona, lessons on expunging cannabis-related criminal records
Implementation of Marijuana Expungement: Lessons from Maricopa County
https://kb.osu.edu/server/api/core/bitstreams/9876bf35-061e-43e7-9971-e5b2fc4ed261/content
US, DEA & Latin America
Trump added Venezuela to drug-transit list & decertified Colombia as a drug-fighting ally
https://www.newsbreak.com/miami-herald-1592483/4237592968826-trump-adds-venezuela-to-drug-transit-list-decertifies-colombia-as-drug-fighting-ally
And a draft bill would authorize Trump to kill anyone he deems to be a narco-terrorist
https://www.nytimes.com/2025/09/19/us/politics/trump-drug-cartels-war-authorization.html
While US Defense Secretary Pete Hegseth said he has “absolute and complete authority” to kill suspected drug smugglers & that cartels are “no different than al-Qaida”
https://www.yahoo.com/news/articles/hegseth-declares-absolute-authority-kill-073943138.html
https://taskandpurpose.com/news/military-drug-cartels-terrorists/
And the head of the FBI said all narco-traffickers must be treated as terrorists
https://www.newsbreak.com/newsnation-2045693/4242093297350-fbi-director-us-must-treat-dangerous-narco-traffickers-as-terrorists
With Secretary of State Rubio is helping to shape the drug war in Latin America
https://www.nytimes.com/2025/09/12/us/politics/rubio-trump-drugs-venezuela.html
And one alleged narco-boat was bombed off of Venezuela with 11 dead
https://www.commondreams.org/opinion/trump-venezuela
And another vessel with 3 killed
https://www.abc.net.au/news/2025-09-16/us-strikes-venezuelan-vessel-at-sea/105777504
With the first Dominican/US anti-drug operation picking up 1,000+ kg of cocaine from the wreckage
https://www.aljazeera.com/news/2025/9/22/dominican-republic-says-it-seized-1000kg-of-cocaine-from-boat-us-bombed
And a third boat bombed with 3 killed
https://www.nytimes.com/2025/09/19/us/politics/trump-boat-strike-drugs.html
And the F-35 stealth jet has now been deployed to the Caribbean drug war
https://www.latintimes.com/f-35-israels-battle-tested-stealth-jet-now-leading-trumps-caribbean-drug-war-589320
And in Colombia, the president warned that Trump’s attacks on suspected narco-boats won’t stop the cartels
https://www.yahoo.com/news/articles/colombia-president-warns-trump-attacks-160421650.html
And in Venezuela, some are cheering the new anti-cartel operations
https://www.theatlantic.com/international/archive/2025/09/machado-trump-narcotics-caribbean/684179/
In Mexico, a Reuters investigation alleged the CIA has been running covert narco-hunting units there for years
https://www.newsmax.com/politics/cia-mexico-drug-trafficking/2025/09/10/id/1225812/
But Mexican President Sheinbaum pushed back on that report
https://www.reuters.com/world/americas/mexico-president-attacks-reuters-report-cias-role-countrys-drug-war-2025-09-12/
And meanwhile, the DEA arrested 600+ linked to the Sinaloa cartel
https://www.aol.com/articles/600-arrested-dea-operation-targeting-174826487.html
DEA bans more fentanyl analogs
https://filtermag.org/dea-permanent-ban-fentanyl-analogs/
And is cracking down on illegal vape cartridges, focusing on synthetic cannabinoids, synthetic cathinones & hydroxymitragynine (7-OH, an active ingredient in kratom)
https://www.dea.gov/press-releases/2025/09/22/operation-vape-trail-cracks-down-illegal-substances-vape-shops
In the Mexican drug war, on how political turnover & property reforms helped to ignite the turf war escalations of 2007 onward
Land titling and political alternation: seeds of Mexico’s drug
https://onlinelibrary.wiley.com/doi/abs/10.1111/ecca.70010
For Brazilian cocaine trafficking into Europe, a thesis project on the Primeiro Comando da Capital (PCC)
Tackling transnational cocaine trafficking in Brazil – An international institution framework regarding criminal organisations’ illicit business model in Brazil
https://kclpure.kcl.ac.uk/ws/portalfiles/portal/350926385/2025_Gallegos_Fiuza_Joao_21219429_ethesis.pdf
On the US drug war, this analysis found $1.5 trillion wasted with a possibility of better drug policies leading to a societal savings of $847 billion over the next 25 years “while improving public health, reducing violent crime, and enhancing civil liberties”
Drug Policy Reform and Integrated Economic Governance: Comparative Analysis of Current Prohibition Costs versus Regulatory Frameworks under Creative Currency Octaves, Public Trust Foundations, Citizens Internet Portal, and Social Zone Harmonization Systems
https://bettertobest.github.io/research-hub/papers/pdfs/drug-policy-reform.pdf
On the 1986 US Maritime Drug Law Enforcement Act & a critique of its territorial overreach & coercive effects
Trawling for minnows on the high seas: Criminal law’s coercive capacities and the U.S. Maritime Drug Law Enforcement Act
https://journals.sagepub.com/doi/pdf/10.1177/14624745251378627
In 1987, NYC’s largest single crack distribution bust
Fixing Capital: Drug Capitalism and Real Estate in Late Twentieth-Century Gotham
https://academic.oup.com/jah/article-abstract/112/2/307/8254190
In US drug policy, a historical analysis of its racist focus
From Medical Practice to Mass Incarceration: A Historical Analysis of Racial and Ethnic Targeting in U.S. Drug Policy
https://psychiatryonline.org/doi/full/10.1176/appi.ajp-rj.2025.210108
Anne Foster’s review of ‘The Suburban Crisis: White America and the War on Drugs’ by Matthew Lassiter
https://www.cambridge.org/core/journals/perspectives-on-politics/article/suburban-crisis-white-america-and-the-war-on-drugs-by-matthew-d-lassiter-princeton-princeton-university-press-2023-680p/6CFCF17A591DC49199888B18EB5FE832
And Lassiter’s response to the review
Response to Anne Foster’s Review of The Suburban Crisis: White America and the War on Drugs
https://www.cambridge.org/core/journals/perspectives-on-politics/article/response-to-anne-fosters-review-of-the-suburban-crisis-white-america-and-the-war-on-drugs/123737661B354EF27E7EEA1132396CCD
And his reviews of her ‘The Long War on Drugs’
The Long War on Drugs. By Anne L. Foster
https://www.cambridge.org/core/journals/perspectives-on-politics/article/long-war-on-drugs-by-anne-l-foster-durham-duke-university-press-2023-224p/EA4C8F0BA666765957AC78B3FF447554
International
Pakistan now the opium capital of the world thanks to Afghani cultivators pushed out by the Taliban
https://www.indiatoday.in/world/story/pakistan-opium-capital-poppy-cultivation-balochistan-afghan-farmers-taliban-ban-2022-terror-funding-global-heroin-market-2785171-2025-09-11
In Iraq, 6 drug traffickers sentenced to death or long prison terms
https://shafaq.com/en/Security/Iraq-steps-up-drug-crackdown-with-severe-punishments
In Indonesia, a man sentenced to death for trafficking ecstasy pills
https://en.antaranews.com/news/378137/indonesian-court-sentences-man-to-death-for-trafficking-ecstasy-pills
In Thailand, an addiction crisis fueled by the cheap methamphetamine known as Yaba
https://theconversation.com/yabas-grip-how-cheap-methamphetamine-is-fuelling-thailands-addiction-crisis-262765
In Singapore, increased punishments for drug vaping with canings & years of jail time
https://www.bloomberg.com/news/newsletters/2025-08-30/singapore-drug-vape-crackdown-to-increase-fines-jail-time-deportation-risk
For cocaine smuggling, a French analysis of the intoxications among body packers & body stuffers
Body packers and body stuffers: cocaine intoxications reported to French poison centers
https://www.tandfonline.com/doi/abs/10.1080/15563650.2025.2546562
🛡️ Harm Reduction News 🛡️
On TikTok, an excellent report on the harms from shutting down Ontario’s safe consumption sites
Tiktok failed to load.Enable 3rd party cookies or use another browser
In Oklahoma, its harm reduction law is moving towards expiration
https://www.readfrontier.org/stories/oklahomas-harm-reduction-law-inches-toward-expiration/
In Scotland, a report says mobile harm reduction units & inhalation rooms could help tackle the drug deaths crisis
https://news.stv.tv/scotland/scotland-could-have-mobile-units-and-inhalation-rooms-to-tackle-drug-deaths-crisis
https://www.thenational.scot/news/25469543.mobile-consumption-facilities-tackle-drugs-crisis/
In Calgary, a mayoral candidate calls for the end of a downtown supervised consumption site
https://globalnews.ca/news/11407802/calgary-mayoral-candidate-calls-for-end-supervised-consumption-site/
Harm Reduction Research
A call to scale up harm reduction programs!
The Opioid Crisis: Scaling Up Treatment And Harm Reduction Programs To Reach More People Who Would Benefit
https://pubmed.ncbi.nlm.nih.gov/40893079/
For women & gender minorities who use drugs, a review on their access gaps for harm reduction interventions
A Narrative Review of Harm Reduction Interventions for Women and Gender Minority Individuals Who Use Drugs
https://www.psychiatryonline.org/doi/10.1176/appi.ajp-rj.2025.210102
And for women who use drugs, an interview of Seattle people on designing healthcare services for them
Fostering Safety, Support, and Hope: A Qualitative Study of Multistakeholder Perspectives on Designing Health Care Services for Women Who Use Drugs in Seattle, Washington, 2023
https://pubmed.ncbi.nlm.nih.gov/40927028/
In schools, a call to implement overdose response protocols & naloxone education
Opioid Overdose Response and Naloxone Education in Schools
https://pubmed.ncbi.nlm.nih.gov/40913541/
In Vancouver, on how the “street sweeps” confiscate the belongings of unhoused people who use drugs & worsen their health & stability
“Street sweeps”: The municipal government-enforced confiscation of personal belongings among unstably housed people who use drugs in Vancouver, Canada
https://pubmed.ncbi.nlm.nih.gov/40908158/
On the potential closure of an Ontario safer opioid supply program, interviews with people who use drugs reported how the program decreased their overdose risk & connected them to services
‘I won’t make it without this program’: the impact of safer opioid supply program closures in Ontario
https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-025-01298-6
On harm reduction vending machines, a 23-month study on how they increased the availability of harm reduction supplies
Evaluating the Impact of Harm Reduction Vending Machines on Supply Distribution: A 23-Month Pre/Post Evaluation
https://www.researchgate.net/publication/395264292_Evaluating_the_Impact_of_Harm_Reduction_Vending_Machines_on_Supply_Distribution_A_23-Month_PrePost_Evaluation
For telehealth substance use disorder treatment, on the geographic & policy factors that influence availability
Geographic and Policy Factors Influence Telehealth Availability for Substance Use Disorder Treatment
https://pubmed.ncbi.nlm.nih.gov/40926169/
In nursing facilities, on improving access to substance use disorder care
Improving Access To Substance Use Disorder Care In Nursing Facilities
https://pubmed.ncbi.nlm.nih.gov/40893083/
For college students, a review of giving them better access to recovery & harm reduction programs
Exploring Evidence-Based Recovery and Harm Reduction Programming for Hazardous Substance Use Among College Students: Paving the Way to Enhanced Accessibility
https://pubmed.ncbi.nlm.nih.gov/40923913/
In Barcelona, on how urban policing models complicate harm reduction practices
Drugs, Law Enforcement and Urban Marginalisation in Downtown Barcelona: The Challenges of Harm Reduction Policing
https://journals.sagepub.com/doi/abs/10.1177/00380385251367862
🍄 Psychedelics, Plant Medicines & Other Psychoactives 🍄
For magic mushrooms, a secret buyer survey of 12 products found zero psilocybin in any of them & “instead contain[ed] muscimol from Amatina muscaria, synthetic tryptamines, or other adulterants”
https://gizmodo.com/some-magic-mushroom-edibles-have-zero-psilocybin-just-junk-that-still-gets-you-high-2000659049
Active Constituents of Psilocybin Mushroom Edibles
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2838765
‘7-OH Did Not Cause the LA Overdose Deaths (Neither Did Kratom)’
https://filtermag.org/7-oh-los-angeles-county-overdose-deaths/
In the NFL, psychedelics popular
https://www.wired.com/story/can-psychedelics-reduce-traumatic-brain-injury-one-nfl-all-pro-thinks-so/
A historical study of Jewish opium dens in New York’s Lower East Side <swoon>
Yiddishe Hop: Opium Dens on the Lower East Side
https://www.tandfonline.com/doi/full/10.1080/1462169X.2025.2554523
A good roundup of ketamine by Jules Evans
https://www.ecstaticintegration.org/p/everything-you-ever-wanted-to-know
And the (controversial) rise of ketamine therapy for teens
https://eu.usatoday.com/story/life/health-wellness/2025/09/09/ketamine-therapys-controversial-rise-in-youth/85623408007/
The Psychoactive Research
For anxiety, a single dose of LSD reduced symptoms
Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder A Randomized Clinical Trial
https://jamanetwork.com/journals/jama/article-abstract/2838505
And for microdosing & pain, this test in healthy volunteers found no painkilling effects
A randomised placebo-controlled study of the effects of lysergic acid diethylamide microdosing (15 μg) on pain perception in healthy volunteers
https://journals.sagepub.com/doi/10.1177/20494637251371626
In people with depression & anxiety from a life-threatening illness, the first randomized controlled trial of psilocybin found reduced depression & anxiety levels
Psilocybin-assisted psychotherapy for depression and anxiety associated with life threatening illness: A phase 2b randomized controlled trial
https://www.sciencedirect.com/science/article/pii/S0163834325001574
And for PTSD, a single dose of psilocybin improved symptoms
Investigating the safety and tolerability of single-dose psilocybin for post-traumatic stress disorder: A nonrandomized open-label clinical trial
https://journals.sagepub.com/doi/10.1177/02698811251362390
And for psilocybin for treatment-resistant depression, a cost-effectiveness analysis found it to be cost-effective at $5,000 or less
Psilocybin-assisted therapy for treatment-resistant depression in the US: a model-based cost-effectiveness analysis
https://www.nature.com/articles/s41398-025-03556-4
For ayahuasca & grieving, it caused significant improvements in “prolonged grief symptomatology, post-traumatic growth, and quality of life, with medium-to-large effect sizes”
Ayahuasca-assisted meaning reconstruction therapy as an early resource for bereavement: a non-randomized clinical trial
https://www.nature.com/articles/s41598-025-13251-5
And for ayahuasca & creativity, a double-blind trial found the effects “on creativity are not uniform”
Ayahuasca-inspired DMT/harmine formulation alters creative thinking dynamics during artistic creation
https://journals.sagepub.com/doi/10.1177/02698811251353256
And for long-term ayahuasca users, brain scans showed significantly higher scores for psychological resilience
Resilience and Brain Changes in Long-Term Ayahuasca Users: Insights From Psychometric and fMRI Pattern Recognition
https://onlinelibrary.wiley.com/doi/10.1002/jmri.70063
For DMT, testing an array of combinations with harmala alkaloids
DMT and harmala alkaloids: an exploratory study of oral Acacia based formulations in healthy volunteers
https://pubmed.ncbi.nlm.nih.gov/40896210/
For DMT, brain scans of the connectome harmonics
N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences
https://www.nature.com/articles/s41386-025-02190-4
For substance use disorders, a review of psychedelics
Psychedelics and substance use disorder treatment
https://pubmed.ncbi.nlm.nih.gov/40541314/
In mice, on the potential cardiotoxicity of microdosing LSD
Assessing the Potential Cardiovascular Risk of Microdosing the Psychedelic LSD in Mice
https://pubs.acs.org/doi/full/10.1021/acsptsci.5c00202
🍃 The Plant & its Products 🍃
🌱 Growing & Extracting 🌱
For LED lighting & defoliation (removing leaves), on the effects on cannabis canopy structure & yield
LED spectra and defoliation independently shape canopy architecture and cannabinoid yield in indoor Cannabis cultivation
https://www.sciencedirect.com/science/article/pii/S0926669025014645
For soil quality, on the effects on cannabinoid & terpenoid content
Impact of Soil Quality on Cannabinoid and Terpenoid Content of Cannabis sativa L.
https://openpublishing.library.umass.edu/jmap/article/id/3150/
For herbicides & weed control, on the yield effects while fertilizing with nitrogen
Response of industrial hemp (Cannabis sativa L.) to preemergence herbicides and weed control under different nitrogen fertilization
https://www.tandfonline.com/doi/abs/10.1080/15427528.2025.2557902
For fertilizers & seed treatments, a test of the effects on hemp growth
THE INFLUENCE OF FERTILISERS AND PRE-SOWING SEED TREATMENT ON THE YIELD OF INDUSTRIAL HEMP (CANNABIS SATIVA L.)
https://lfi-naas.org.ua/en/the-influence-of-fertilisers-and-pre-sowing-seed-treatment-on-the-yield-of-industrial-hemp-cannabis-sativa-l/
In cannabis haploids (doubled chromosomes, a common agronomic technique), a review of techniques & the effects on cultivars
Haploid Production in Cannabis sativa: Recent Updates, Prospects, and Perspectives
https://pubmed.ncbi.nlm.nih.gov/40563952/
In California cannabis farms, a thesis project on the water runoff carrying chemical contaminants
Assessment of Chemical Contaminants in Runoff from Cannabis Farm Cultivation in Carpinteria, California: Implications for Water Quality and Ecosystem Health
https://www.proquest.com/openview/3e96652d95184f968bf166d5430661f4/1
On the strong growth effects of microalgae & cyanobacteria mixtures
Effect of microalgae and a cyanobacteria mixture on germinative activity, growth, and cannabinoid production in Cannabis sativa plants
https://link.springer.com/article/10.1007/s10811-025-03637-3
On chaga mushroom-derived nanoparticles & a thesis project on their effects on cannabis growth
Innovation of chaga mushroom-derived nanoparticles (CNPs) and assessment of effects on germination, agronomic performance, and phytochemistry of Cannabis sativa
https://uwo.scholaris.ca/items/cedab917-bc58-4b6e-8c5d-fa0bcc3fa27f
For plant growth, the synergistic effects of plant growth regulators & silver nanoparticles
Synergistic enhancement of Cannabis sativa L. In vitro growth, metabolite production, and antioxidant activity using silver nanoparticles and plant growth regulators
https://link.springer.com/article/10.1007/s11240-025-03209-w
For titanium & silver nanoparticles, an analysis of their effects on hemp
Artificial intelligence-driven validation of silver and titanium nanomaterials impact on morpho-chemical potential of industrial hemp (Cannabis sativa L.)
https://link.springer.com/article/10.1007/s12210-025-01360-2
In cannabis, on the growth effects of the biostimulants harpin (aß) proteins & the polysaccharide laminarin
Metabolomics-Driven Investigation of Harpin αβ and Laminarin Effects on Cannabis sativa L. Employing GC/EI/MS and 1H NMR Metabolomics
https://www.mdpi.com/2813-3145/4/3/16
In male Thai hemp plants, on using ethephon for enhanced seed yield
Optimizing Ethephon Concentrations for Male Plant Feminization and Enhanced Seed Yield in Dioecious Thai Hemp (Cannabis sativa L. cv. RPF3)
https://www.mdpi.com/2037-0164/16/3/111
For flushing (a common legacy practice of reducing fertilizer before harvest), the practice was found to decrease yield but potentially improve smoking quality
Exploring the Legacy Practice of Flushing in Controlled-environment Production of High-CBD Cannabis (Cannabis sativa)
https://journals.ashs.org/view/journals/hortsci/60/10/article-p1818.xml
For irrigation, a thesis project on using sensors to optimize the growth of hemp & hot pepper
Sensor-Based Irrigation Strategies for Optimizing Growth, Physiology and Yield of Specialty Crops (i.e., Hot Pepper and Dual-Purpose Hemp)
https://www.proquest.com/openview/34f0d22d1019d21225092628a3619693/1
For the ecology of cannabis, a thesis project on its response to biotic interactions & abiotic stress
Ecological Perspectives on Cannabis sativa Phytochemistry: Biotic Interactions and Abiotic Stress in Managed and Natural Systems
https://www.proquest.com/openview/598ff0e7016d9deca1fe61b566a47cd8/1
In Uzbekistan, on cultivating cannabis even in weak to medium-saline soils
Cultivation of a new culture of technical Cannabis in Uzbekistan
https://floraandfona.org.in/Uploaded%20Pdf/311/39-48.pdf
In protoplast cannabis culture, the age of the donor material was found to be critical
Early protoplast culture and partial regeneration in Cannabis sativa: gene expression dynamics of proliferation and stress response
https://pubmed.ncbi.nlm.nih.gov/40546425/
For cannabis cultivars, on the inheritance patterns of the cannabinoids & other metabolites
Inheritance and covariation of specialised metabolites among cannabis chemotypes
https://www.publish.csiro.au/CH/justaccepted/CH25108
A protocol for vegetative propagation
Vegetative Propagation of Cannabis sativa and Resin Obtained From its Female Inflorescences
https://en-cdn.bio-protocol.org/pdf/Bio-protocol5204.pdf
In micropropagation, on using machine learning to detect nutrient-related cannabis symptoms
Decoding the cannabis tissue culture puzzle: Machine learning analysis of cannabis in vitro morpho-physiological disorders expands the potential for precision micropropagation
https://www.sciencedirect.com/science/article/pii/S1687157X25001131
For Septoria leaf spot, on identifying resistant cannabis germplasm
Screening of Cannabis sativa germplasm for susceptibility to Septoria leaf spot
https://apsjournals.apsnet.org/doi/abs/10.1094/PDIS-07-25-1367-RE
A genetic analysis of the Fusarium fungus infecting cannabis & an analysis of their mycotoxin output
Genomic analyses of five Fusarium species infecting cannabis (Cannabis sativa L.) plants in Canada and their potential for mycotoxin production
https://www.tandfonline.com/doi/abs/10.1080/07060661.2025.2543779
On tools to create non-psychoactive cannabis genotypes
Development of tailored non psychoactive Cannabis sativa L. genotypes in half sib seed progeny segregation generation adhering to requirements through morpho-cannabinoid & terpene profile diversity
https://www.sciencedirect.com/science/article/abs/pii/S0963996925018149
An analysis of cannabis from Aceh, Indonesia
Profiling of various dry Cannabis sativa from Aceh, Indonesia, based on cannabinoids spectroscopy characteristics
https://link.springer.com/article/10.1186/s41935-025-00480-y
⚙️ Analyzing & Formulating ⚙️
For CBD bioavailability, on pheophytins for improved absorption
Pheophytins as bioenhancers: Improving cannabidiol bioavailability and efficacy in cannabis extracts
https://www.sciencedirect.com/science/article/abs/pii/S0378517325010312
🍞 Food, Nutrition & Hemp Seeds 🍞
For European hemp food products, an analysis of their metabolites
Quality and safety assessment of hemp-based food products: Insights into seeds, flours, and oils
https://www.sciencedirect.com/science/article/abs/pii/S0889157525011536
For cereals containing hemp, an analysis of US market data on who’s buying it
Insights into the U.S. Market for Cereals Containing Hemp: Evidence from Scanner Data
https://www.tandfonline.com/doi/full/10.1080/10454446.2025.2557803
For cannabinoids in food, a book chapter on their public health risks & opportunities
Cannabinoids in Foods: Public Health Implications and Applications
https://link.springer.com/rwe/10.1007/978-3-031-32047-7_81-1
In food from hemp seed oil, cake flour & protein concentrate, they were found to have “ substantial health-promoting potential, including senescence delay” (slowed aging)
Promising Dietary Supplements with Potential Senotherapeutic Effects: Aqueous Extracts from Enzymatically Hydrolysed Hemp Seed Cake Flour and Hemp Seed Protein Concentrate
https://pubmed.ncbi.nlm.nih.gov/40563366/
In a wine made from Muscat grapes on the island of Samos (a sweet Greek dessert wine), on the effects of adding cannabis, salvia & lemon balm
Volatile Composition of Muscat of Samos wine after Pre- and Post-fermentation Addition of the Herbs Salvia officinalis, Melissa officinalis and Cannabis sativa
https://www.ijagbio.com/pdf-files/25-256.pdf
In pregnant sheep, feeding them hemp did not cause any detectable differences besides lamb weight increase
Is hemp (Cannabis sativa) safe to feed pregnant sheep?
https://pubmed.ncbi.nlm.nih.gov/40756673/
In laying hens, adding hemp seeds to their food was associated with more pecking at the feeder but no other substantial behavioral changes
Effect of enrichment with hemp seeds on the behaviour of laying hens in a cage-free system
https://www.research.unipd.it/handle/11577/3559923
On the compression loading of hemp oil
COMPUTATION OF FITTING FUNCTIONS FOR DESCRIBING HEMP OIL OUTPUT PARAMETERS UNDER COMPRESSION LOADING
https://www.imda.cz/documents/ICMD2025_Abstracts.pdf#page=23
🏗️ Industrial Uses & Fiber 🏗️
In steel, Moroccan at cannabis extract as an eco-friendly corrosion inhibitor
Exploring Moroccan Cannabis Sativa L Plant Extract as a Sustainable Corrosion Inhibitor for Mild Steel in 1 mol/L HCl Solution
https://www.sciencedirect.com/science/article/pii/S2667266925000751
For cleaning water of heavy metal ions, on the use of hemp & activated carbons
Use of Hemp (Cannabis sativa) Biomass Components and Activated Carbons Based on Them to Remove Pollutants from Aqueous Media: 1. Metal Ions
https://link.springer.com/article/10.1134/S199542122570056X
For turning dairy manure into a biofuel, hemp stalk enhanced the combustion performance of hydrochar
Optimizing co-hydrothermal carbonization of organic dairy manure and hemp stalks: a multi-criteria decision-making approach
https://www.sciencedirect.com/science/article/pii/S2772427125001731
And on improving the conversion of hemp residue into biofuels
Thermochemical valorization of industrial hemp residues: Advances in hydrothermal conversion for biofuels and chemicals
https://www.sciencedirect.com/science/article/pii/S0961953425007603
On biomedical implants of 3D-printed PLA–hemp microfiber composites
Characterization of 3D-Printed Polylactic Acid (PLA)–Hemp Microfiber-Reinforced Biomedical Implant Composite Material
https://link.springer.com/article/10.1007/s12221-025-01159-w
For 3D printing, on turning hemp processing waste into biocomposite filament
Utilization of Hemp Processing Waste for 3D Printing of Biocomposites
https://link.springer.com/article/10.1007/s12649-025-03314-z
On creating renewable biodegradable biopolymers from hemp waste
Design and Research of Eco-Friendly Biodegradable Composites Based on Renewable Biopolymer Materials, Reed, and Hemp Waste
https://www.proquest.com/openview/cacb1827b8d973f94cec7bcf203e8da1/1
On the effects of salt water on hemp fiber bio-composites
Investigation on the Mechanical Behavior of Salt Water Immersed Hemp Fibre Reinforced Bio-Composites
https://www.e3s-conferences.org/articles/e3sconf/pdf/2025/48/e3sconf_icceas2025_02021.pdf
On hemp hurd-derived biochar for agricultural applications
Characterization of Hemp Hurd-Derived Biochar for Potential Agricultural Applications
https://www.mdpi.com/2073-4395/15/9/2136
For petunia & geranium flowers, hemp hurd could be a substitute for peat
Hemp Hurd Fiber as a Substitute for Peat in Container Production of Petunia and Geranium
https://journals.ashs.org/view/journals/hortsci/60/8/article-p1251.xml
On hemp as food packaging, a review of green processing routes
Valorization of hemp biomass through green methods: A sustainable approach for next-generation food packaging
https://www.sciencedirect.com/science/article/abs/pii/S0924224425004315
In grape packaging, adding cannabis pollen reduced mold formation
Bio-based pectin films with cannabidiol extract from pollen of Cannabis sativa L - active packaging to protect anthocyanins in Thomson seedless dark grapes
https://www.sciencedirect.com/science/article/pii/S092777652500640X
For molded packaging, a thesis project on hemp-derived nanocellulose
Nanocellulose from Hemp: Characterization for Molded Pulp Applications
https://uwspace.uwaterloo.ca/items/4b8834aa-ba0e-473d-8dec-8c68fe6b414b
For high-performance thermoplastic polymers (such as circuit boards), on adding hemp to polyetheretherketone for better hardness & thermal stability
Hemp-PEEK composites: surface treatment, processing, and performance
https://www.degruyterbrill.com/document/doi/10.1515/ipp-2025-0019/html
For latex composites & their low resistance to shock loads, adding hemp fiber was an economical fix for tensile & bending strength
The effect of volume fraction and fiber length on the tensile and bending strength of latex matrix composites reinforced by hemp fiber waste
https://pubs.aip.org/aip/acp/article-abstract/3354/1/030023/3363507/The-effect-of-volume-fraction-and-fiber-length-on
On using hemp pulp as a feedstock for pyrolysis (thermal decomposition into useful material) & the dangers of toxicity in aquatic organisms
Catalytic upgrading of hemp (Cannabis sativa) pyrolysis oil over CoMo/zeolite and in‐silico toxicity assessment
https://scijournals.onlinelibrary.wiley.com/doi/abs/10.1002/bbb.70036
On the characteristics of a hemp oil–based surfactant
Synthesis and Physicochemical Properties of a Surfactant Based on Hemp Oil
https://link.springer.com/article/10.1134/S0036024425701742
On creating a PET polyester composite with hemp & shrimp shell powder
Effect of Aminosilane-Treated Hemp Viscose Fabric and Shrimp Shell Powder on Sustainable Polyethylene Terephthalate Polyester Structural Composite
https://link.springer.com/article/10.1007/s12221-025-01163-0
On creating hemp-based CNC-knitted construction systems
Testing Ecosystem and Collaborative Circular Business Model Frameworks for Hemp-Based CNC-Knitted Construction at Low Technology Readiness Levels
https://www.researchgate.net/publication/395491668_Testing_Ecosystem_and_Collaborative_Circular_Business_Model_Frameworks_for_Hemp-Based_CNC-Knitted_Construction_at_Low_Technology_Readiness_Levels
In Pakistan, on the potential of hemp fiber
Implications, challenges, and prospects of industrial hemp as a sustainable natural fiber in Pakistan: An overview
https://agris.fao.org/search/en/providers/122356/records/6878e8f90868163a2f752728
On the agrotechnology of extracting fiber from hemp
Agrotechnology of hemp cultivation and the process of fiber extraction
https://altumnova.com/index.php/tsir/article/view/14/12
For hemp insulation composites, on the impact of fiber size & adhesive ratio
Impact of fiber size and poly (vinyl acetate) adhesive ratio on the hygrothermal properties of non-industrial hemp-based insulation composites
https://www.sciencedirect.com/science/article/abs/pii/S095006182503613X
On the hybrid construction of rammed earth & hemp concrete
Advanced Characterization of Rammed Earth and Hemp Concrete: Towards Hybrid Solution
https://journal.augc.asso.fr/index.php/ajce/article/view/5231
For hempcrete, this thesis project analyzed the impact of binder composition & hemp hurd particles
Experimental Investigation of the Impact of Binder Composition and Hemp Hurd Particles on the Mechanical and Hygrothermal Performance of Hempcrete
https://ruor.uottawa.ca/server/api/core/bitstreams/5931d9bf-2147-4542-a8e2-6789a8df6107/content
In Australia, an analysis of hemp building materials
Assessing the Techno-Sustainability of Hemp-Based Building Materials: A Comparative Study in the Australian Context
https://www.sciencedirect.com/science/article/pii/S2589234725001472
In a retrofitted school building, on using hemp/polymer composite for seismic reinforcement
Numerical study on the application of hemp-FRP for seismic retrofitting of a RC school building
https://pubs.aip.org/aip/acp/article-abstract/3315/1/360002/3363112/Numerical-study-on-the-application-of-hemp-FRP-for
For lime mortars with volcanic ash, on enhancing them with hemp shiv
Enhancing the Properties of Lime Mortars with Volcanic Ash and Hemp Shiv: A Sustainable Approach for Restoration Applications
https://dadun.unav.edu/server/api/core/bitstreams/176335bc-fca1-4d73-a1e2-05699c4df3a5/content
In Bhutan, hemp composites as an alternative for construction
Hemp Composite Material Samples as an Alternative for Construction in Bhutan
https://www.researchgate.net/publication/395457104_Hemp_Composite_Material_Samples_as_an_Alternative_for_Construction_in_Bhutan
🌿 THE CANNA-SCIENCE ARCHIVE 🌿
A review of the therapeutic use of cannabis & cannabinoids
Therapeutic use of cannabis and cannabinoids: benefits and risks
https://pubmed.ncbi.nlm.nih.gov/40938211/
🏥 Public Health, Legalization Effects & Bioassays 🏥
In healthy humans, hemp products caused positive THC urine tests
The acute and chronic pharmacokinetics and pharmacodynamics of oral cannabidiol with and without low doses of delta-9-tetrahydrocannabinol
https://academic.oup.com/jat/advance-article/doi/10.1093/jat/bkaf075/8211679
In US commercially insured adults, there’s been a ~doubling of cannabis- related healthcare encounters from 2017 to 2022
Cannabis-related healthcare encounters among U.S. commercially insured adults
https://pubmed.ncbi.nlm.nih.gov/40516767/
In countries that legalized medical cannabis, public health data showed a lowered use of tobacco & amphetamines
Medical cannabis legalization and the use of illicit drugs, alcohol, and tobacco
https://link.springer.com/article/10.1186/s42238-025-00324-5
In sexual minority US adults, on an analysis of their cannabis usage, with bisexual women leading the way!
Cannabis use among sexual minority adults: insights from recent U.S. nationally representative data
https://www.sciencedirect.com/science/article/abs/pii/S0306460325002564
There’s a reason I have a type...
In California adults, cannabis use was twice as likely than tobacco use, with higher levels of education associated with cannabis use
Diverging Patterns of Educational Disparities Among Cannabis Users and Cigarette Smokers
https://www.sciencedirect.com/science/article/pii/S2773065425001245
In Germany, a cohort analysis found that cannabis use tended to decrease with age
Age-period-cohort analysis of past 12-month cannabis use in Germany (1995-2021)
https://pubmed.ncbi.nlm.nih.gov/40537976/
In Germany, 30% of cannabis users felt external stigmatization & 22% reported self-stigma
“Those pot heads” – perceived external stigma and self-stigma among cannabis users in Germany: prevalence and associations with socio-demographics, cannabis use patterns and psychological distress
https://link.springer.com/article/10.1186/s42238-025-00328-1
In France, 5% of adults co-use tobacco & cannabis & most of those who use cannabis also use tobacco
Prevalence and factors associated with tobacco and cannabis co-use in France: results from a national representative survey
https://www.sciencedirect.com/science/article/pii/S2772724625000642
In Irish drivers suspected of impairment, on the prevalence of cannabis & polydrug use
Drug and polydrug detection in drivers suspected of driving under the influence of an intoxicant in Ireland 2012–2018: a national repeated cross-sectional study
https://www.tandfonline.com/doi/abs/10.1080/15389588.2025.2544346
In Canadian drivers, on the prevalence of cannabis & alcohol detection
A comparison of the prevalence of cannabis and alcohol use among drivers and passengers in British Columbia and Ontario, Canada
https://www.sciencedirect.com/science/article/pii/S0001457525003306
For assessing cannabis use motives, the development & validation of the comprehensive Cannabis Motives Questionnaire
Development and validation of the Comprehensive Cannabis Motives Questionnaire (CCMQ)
https://pubmed.ncbi.nlm.nih.gov/40537924/
Personally, it’s when my wife tells me to “go to the basement”.
Which is code for quietly letting me know that I’m being a little bit too much of a jerk & it’s time to get a tad twisted & be nicer to be around.
One wishes that they might not need the crutch, but better a mental health crutch than an unhappy wife.
On developing a cannabis health literacy questionnaire
Development of a cannabis health literacy questionnaire: preliminary validation using the Rasch model
https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-025-23770-5
On using a gamified participant-driven tool for monitoring cannabis & tobacco use
Co-creating a gamified tool for cannabis and tobacco use monitoring: Participant-driven development
https://www.sciencedirect.com/science/article/pii/S0376871625003333
In cerebrospinal fluid, on detecting THC with a LC-MS/MS method
Detection of ∆9-THC in cerebrospinal fluid: new validation strategies for forensic and clinical toxicology applications
https://www.tandfonline.com/doi/abs/10.1080/00450618.2025.2532401
On analyzing cannabinoid levels in human blood with a LC-MS/MS
Analysis of Seven Selected Cannabinoids in Human Plasma Highlighting Matrix and Solution Stability Assessments
https://pubmed.ncbi.nlm.nih.gov/40972134/
For highly sensitive CBD detection, an electrochemical MOF-based sensor
Development of a MOF-based electrochemical sensor for trace detection of cannabidiol in biological, environmental, and plant-derived samples
https://www.sciencedirect.com/science/article/abs/pii/S001346862501730X
Abstracts from the European Societies of Toxicology Conference (EUROTOX 2025)
France proposes CBD as a reprotoxicant (damage to reproduction)
S21-03 CBD: a reprotoxicant proposed to be identified under CLP
https://www.sciencedirect.com/science/article/abs/pii/S0378427425016972
For cannabis self-titration, an epidemiological analysis on how people modulate their use depending on THC levels
Self-Titration of Cannabis Consumption: An Epidemiological Perspective
https://www.sciencedirect.com/science/article/abs/pii/S0022395625005278
For an oral CBN product, a toxicology study found no issues in a range of tests
P12-13 Safety Assessment and Investigation into the General and Neuro-Toxicologic Potential from Repeated Oral Administration of Cannabinol, TruCBN™
https://www.sciencedirect.com/science/article/abs/pii/S0378427425019307
In rats, how CBG & CBC move through their system
P04-03 Blood pharmacokinetics and brain levels of the minor phytocannabinoids cannabigerol (CBG) and cannabichromene (CBC) and their metabolites in rats
https://www.sciencedirect.com/science/article/abs/pii/S037842742501803X
In a tissue model of Parkinson’s disease, a commercial CBD oil caused neuroprotective effects without toxicity
P33-08 Investigation of the possible neuroprotective and therapeutic potential of CBD oil in the 1-methyl-4 phenylpridinium (MPP+) and/or manganese-induced in vitro model of Parkinson’s disease
https://www.sciencedirect.com/science/article/abs/pii/S0378427425025858
A review of the acute toxicity of synthetic & semi-synthetic cannabinoids
CEC06-01 Synthetic cannabinoids and semi-synthetic cannabinoids: understanding the acute toxicity (harms) related to these substances
https://www.sciencedirect.com/science/article/abs/pii/S0378427425016194
In Chile, an analysis of the THC & synthetic cannabinoid levels found in seized vapes
P13-05 Risk Assessment of Delta-9-Tetrahydrocannabinol (Delta-9-THC) in Vape Devices Seized in Chile
https://www.sciencedirect.com/science/article/abs/pii/S0378427425019629
In neural cells, the synthetic cannabinoid THJ-2201 disrupted the mitochondria (powerhouse of the cell)
P28-17 The synthetic cannabinoid THJ-2201 reduces the motility of mitochondria and increases their accumulation in newly formed neurites
https://www.sciencedirect.com/science/article/abs/pii/S0378427425024051
On CBD as a novel food from a European Food Safety Authority perspective
S21-01 EFSA perspective: Cannabidiol (CBD) as a novel food
https://www.sciencedirect.com/science/article/abs/pii/S0378427425016959
From the UK Food Standards Agency, on their guidance for CBD consumers
S21-02 UK FSA perspective: CBD consumer guidance
https://www.sciencedirect.com/science/article/abs/pii/S0378427425016960
On methods of analyzing CBD-based products
P02-11 Analytical study regarding cannabidiol-based products
https://www.sciencedirect.com/science/article/abs/pii/S0378427425017783
🧒 Adolescents & Young Adults 🧒
In brain scans of young adult cannabis users, “THC reduced within-network intrinsic connectivity in corticostriatal circuits and other networks associated with sensory systems, interoceptive experiences, and spatial reasoning”
Δ9-Tetrahydrocannabinol Alters Limbic and Frontal Functional Brain Connectomes Among Young Adult Cannabis Users
https://www.sciencedirect.com/science/article/pii/S2451902225002824
In young adults with cannabis use disorder, they had no alterations to their levels of social cognition
Social cognition in young adults who endorse a cannabis use disorder
https://link.springer.com/article/10.1007/s00213-025-06890-z
In US adolescents, on their usage of cannabis vapes & flavored solutions
Trends in US Adolescent Use of Vaping and Flavored Solutions for Marijuana Consumption, 2021–2024
https://www.sciencedirect.com/science/article/pii/S1054139X25002952
In young adult, on their reactions to cannabis warning labels
Cannabis warning labels, sensory marketing, and electronic word-of-mouth: AI-facilitated textual analysis of a randomized experiment among youth and young adults
https://www.tandfonline.com/doi/abs/10.1080/02650487.2025.2548647
For young adults & derived cannabis products, on their knowledge & use intentions
Correlates of Derived Cannabis Product Awareness, Knowledge, Use, and Use Intentions Among Young Adults
https://journals.sagepub.com/doi/abs/10.1177/10901981251374672
Among young adults, loneliness is linked to higher frequency & more problematic use of alcohol & cannabis use
The Longitudinal Relationship of Loneliness With Frequency and Problematic Use of Alcohol and Cannabis Among Young Adults
https://www.jahonline.org/article/S1054-139X(25)00288-5/pdf
And in this study, college students who used alcohol had lower loneliness but increased consequences from alcohol or cannabis use, which were linked to greater loneliness
Exploring the Impact of Loneliness on Alcohol and Cannabis Use Among College Students
https://www.tandfonline.com/doi/abs/10.1080/10826084.2025.2556245
In college students, the co-use of alcohol & cannabis was found to have an additive subjective effect
Comparing subjective effects and intoxication on simultaneous alcohol and cannabis use occasions relative to alcohol- or cannabis-only occasions
https://pubmed.ncbi.nlm.nih.gov/40511871/
I mean, yes, of course. When you hit that sweet spot, it’s glorious.
And when you miss that sweet spot, the spins & dark nights of the soul.
In young adults, binge drinking & cannabis use were linked to impaired decision making
Decision-making impairments in binge drinking and cannabis use among young adults
https://psycnet.apa.org/record/2026-64391-001
In college students simultaneously using alcohol & cannabis, coping & positive effect motives did not moderate the relationship with protective behavioral strategies
Simultaneous Alcohol and Marijuana Use Versus Alcohol Use Only on Protective Behavioral Strategies: The Moderating Influences of Coping and Enhancement Motives
https://www.tandfonline.com/doi/abs/10.1080/10826084.2025.2556254
In young adults, combining cannabis with heavy episodic drinking happened more often when they experienced internalizing symptoms (a latent factor consisting of depression, anxiety & stress indicators)
Internalizing symptoms are indirectly associated with simultaneous alcohol and cannabis use through specific motives for simultaneous use: A longitudinal study of young adults
https://onlinelibrary.wiley.com/doi/pdf/10.1111/acer.70147
For college students, interviews about how they view THC products
Integrating the knowledge, attitudes, and practices (KAP) framework with product packaging perceptions: THC products and college students
https://www.tandfonline.com/doi/abs/10.1080/07448481.2025.2552829
In young adults, on the reasons they use cannabis or derived cannabinoids
Cannabis and Derived Cannabis Use, Motives, and Consequences Among US Young Adults: Findings From a Cross-Sectional Mediation Study
https://pubmed.ncbi.nlm.nih.gov/40709804/
In UK youth, an analysis of the factors that influenced their tobacco & cannabis use
Factors Influencing Co-Use of Tobacco and Cannabis Amongst Young Adults in UK Further Education Colleges: A Qualitative Study
https://pubmed.ncbi.nlm.nih.gov/40556347/
For youth diverted from the juvenile legal system, on creating an app to reduce cannabis use
User-centered Design of an Adjunct Smartphone App to Reduce Cannabis Use among Youth Diverted from the Juvenile Legal System
https://link.springer.com/article/10.1007/s10802-025-01370-6
In a mouse model of adolescent binge drinking, giving them omega-3 fatty acids improved their recovery after drinking & increased the CB1 receptors levels in the hippocampus (memory center of the brain)
Omega-3 Fatty Acids Mitigate Long-Lasting Disruption of the Endocannabinoid System in the Adult Mouse Hippocampus Following Adolescent Binge Drinking
https://pubmed.ncbi.nlm.nih.gov/40564971/
In a rat model of adolescent alcohol use leading to adult cognitive impairment, these deficits were lessened by early life stress via the endocannabinoid system
Prior restraint stress counteracts memory deficits associated with adolescent alcohol exposure by targeting both the hippocampal endocannabinoid and glutamatergic systems
https://www.sciencedirect.com/science/article/abs/pii/S0376871625003448
🧠 The Brain & Neurological Disorders 🧠
For people with multiple sclerosis, a thesis project on the chronic effects of THC & CBD
Unique Effects of Chronic THC and CBD Use in Multiple Sclerosis on Cognitive and Motor Function, Neuroimaging, and Quality of Life Amid Hazy Cannabis Legality
https://www.proquest.com/openview/a1f6b0d1de5536ee39e7b40647999922/1
In people with traumatic brain injuries (TBIs), those who were co-using cannabinoids & opioids or cannabinoids & stimulants before their injury had higher odds of mortality & severe TBI, respectively
The Role of Pre-injury Polysubstance Use on Traumatic Brain Injury and its Impact on Health Resource Utilization Among the U.S. Trauma Patients
https://www.researchsquare.com/article/rs-6017336/v1
For the CB1 receptor in the brain, a review of the diseases it may help
Cannabinoid Receptor 1: The Neural Gatekeeper of Health and Disease
https://pubmed.ncbi.nlm.nih.gov/40968433/
In a mouse model of Alzheimer’s disease, a combination of THC & CBD did not have a prominent therapeutic effect
Combination treatment with medium dose THC and CBD had no therapeutic effect in a transgenic mouse model for Alzheimer’s disease but affected other domains including anxiety-related behaviours and object recognition memory
https://www.sciencedirect.com/science/article/pii/S0091305725001480
For Alzheimer’s disease, a computer analysis found THC to be the best candidate for inhibiting the cholinesterase enzyme
Exploring Cannabis sativa L for Anti-Alzheimer Potential: An Extensive Computational Study including Molecular Docking, Molecular Dynamics, and ADMET Assessments
https://pubmed.ncbi.nlm.nih.gov/40525419/
In a tissue model of nerve injury, targeting the CB1 receptor created a pro-regenerative microenvironment via the PINK1/Parkin pathway & the mitochondria (powerhouse of the cell)
Targeting CB1R Rewires Ca2+-Dependent Mitophagy to Promote Nerve Regeneration
https://pubmed.ncbi.nlm.nih.gov/40963929/
In a rat model of synaptic transmission, activating the CB1 receptor enhanced synaptic plasticity in the dentate gyrus (a key brain area for the formation of new episodic & spatial memories)
Cannabinoid agonist, WIN 55,212-2, increases in vivo paired-pulse facilitation, long-term potentiation, and Arc expression in the dentate gyrus
https://www.sciencedirect.com/science/article/abs/pii/S0006899325005001
For the blood-brain barrier, the CB1 receptors of the astrocytes (the most predominant brain support cell)… do something behind a paywall
Astrocytic Cannabinoid Receptor 1 Governs Stress Resilience by Orchestrating Blood-Brain Barrier Integrity
https://pubmed.ncbi.nlm.nih.gov/40960683/
💭 Mental Health, Addiction & Cannabis Use Disorder 💭
In primary care, implementing screenings for cannabis use disorder increased treatment initiation by 1 in 10,000 patient visits but treatment engagement (continued visits) did not change
Implementing Care for Cannabis and Other Drug Use in Adult Primary Care: Outcomes of a Cluster-Randomized Implementation Trial
https://www.sciencedirect.com/science/article/abs/pii/S074937972500580X
Kind of seems like the definition of the juice not being worth the squeeze.
For cannabis & alcohol use disorder, on how older adults are less likely to endorse certain criteria
DSM-5 Criteria for Alcohol and Cannabis Use Disorders: Are Older Adults Less Likely to Endorse Certain Criteria?
https://pubmed.ncbi.nlm.nih.gov/40566271/
In people with alcohol use disorder, CBD increased the levels of glutathione, glutamine, GABA (the brain’s primary inhibitory neurotransmitter) & glutamate (the brain’s primary excitatory neurotransmitter)
The effect of cannabidiol on neurometabolite levels in alcohol use disorder
https://pubmed.ncbi.nlm.nih.gov/40551671/
In people with alcohol use disorder, this thesis project found that both CBD & THC reduced negative affect
Shared Mechanisms of Alcohol Use Disorder and Anxiety and Effects of the Endocannabinoid System
https://www.proquest.com/openview/e6615c50d9e79248b099ead4963a31aa/1
In people with psychosis also experiencing pain, their levels of pain were not significant predictors of their cannabis use, though the use of antipsychotics with low sedating effects were associated with greater amount of cannabis use
Pain Is Not a Predictor of Cannabis Use in People With Psychotic Disorders
https://www.tandfonline.com/doi/abs/10.1080/15504263.2025.2517176
In a drug discrimination test in rats, THCV could mimic or block their discrimination of THC
Tetrahydrocannabivarin (THCV) Dose Dependently Blocks or Substitutes for Tetrahydrocannabinol (THC) in a Drug Discrimination Task in Rats
https://www.mdpi.com/2218-273X/15/9/1329
For methamphetamine use disorder, on development of an intranasal CBD exosomes for improved brain penetration & reduced neuroinflammation
Intranasal delivery of cannabidiol-loaded hypoxic exosomes for targeted treatment of methamphetamine addiction via enhanced brain penetration and neuroinflammation modulation
https://www.sciencedirect.com/science/article/abs/pii/S1001841725009726
🧬 Reproduction & Hormones 🧬
In people who just had a baby, interviews of how & why they were using cannabis
Cannabis Use Behaviors and Desired Interventions Among Postpartum Individuals With Frequent Cannabis Use in Early Pregnancy: A Qualitative Study
https://pubmed.ncbi.nlm.nih.gov/40539624/
In Michigan pregnancies, 1 in 6 were estimated to be using cannabis
Prevalence and characteristics of prenatal cannabis use in Michigan, USA: A statewide population‐based pregnancy cohort
https://onlinelibrary.wiley.com/doi/pdf/10.1111/add.70188
In babies with prenatal cannabis exposure, they did not have a higher risk for developing retinopathy of prematurity (an eye disease of abnormal blood vessel growth in premature infants)
143 The effect of prenatal cannabis exposure on the development of retinopathy of prematurity
https://www.sciencedirect.com/science/article/abs/pii/S1091853125003234
For mothers, fathers & children, a hair analysis of their endocannabinoid levels across the perinatal period
Stability and inter-family associations of hair endocannabinoid and N-acylethanolamines across the perinatal period in mothers, fathers, and children
https://pubmed.ncbi.nlm.nih.gov/38658668/
In states that legalized cannabis, pregnant women had increased alcohol consumption
Alcohol Consumption During Pregnancy and State Implementation of Legal Nonmedical Cannabis Retail Sales in the United States, 2011 to 2023
https://www.sciencedirect.com/science/article/abs/pii/S0749379725005732
In a cellular model of prenatal cannabis exposure, a thesis project review of THC’s changes to the placental immune networks
Prenatal Maternal Cannabis Exposure and Neurobehavioral Risk: A Mechanistic Review Linking Δ9-THC-Mediated Perturbation of Placental Immune Networks to TGF-β SMAD-Dependent Signaling Pathway Informed by BeWo Cell Model
https://www.proquest.com/openview/2de79d842620958004ce6c7e417cbfa6/1
In dogs with pyometra (a serious infection of the uterus), an analysis of their endocannabinoid profiles found anandamide levels significantly reduced in closed-cervix pyometra
Endocannabinoid System Regulation in Pyometra-Affected and Healthy Canine Uteri
https://www.preprints.org/frontend/manuscript/2dcb27269d14d68c26121e19f88118e9/download_pub
🦠 The Immune System & Microbial 🦠
In people with HIV, cannabis use was not associated with any negative memory effects
Evaluating Cross-Sectional Associations Between Cannabis Use and Prospective Memory in People with HIV
https://link.springer.com/article/10.1007/s10461-025-04851-3
For the antimicrobial properties of cannabinoids, an analysis warning of the problem of false correlations
The importance of verifying biological activity predictions in metabolomics studies of natural products: A case study on antimicrobial properties of Cannabis sativa (hemp)
https://www.sciencedirect.com/science/article/pii/S1874390025011048
🦴 Pain, Musculoskeletal, Inflammation & Surgeries 🦴
In healthcare practitioners specialized in arthritis, a survey found that they sought better support for medical cannabis decision making
‘They’re Looking for More Answers Than I Can Give!’: A Qualitative Study Exploring Clinicians’ Needs in Medical Cannabis Decision Support
https://www.proquest.com/openview/72408c893a7b4d5065b8a8051fdb2446/1
For Mohs surgery (a minor procedure to remove skin cancer), cannabis users had increased postoperative pain & opioid use
Cannabis Use Is Associated With Increased Postoperative Pain and Opioid Use After Mohs Micrographic Surgery: A Retrospective Cohort Analysis
https://pubmed.ncbi.nlm.nih.gov/40557965/
In people with arthritis, they had lower levels of 2-AG & higher levels from the ethanol amine group (including anandamide, docosahexaenoyl-EA & palmitoleoyl-EA) as well as the oxylipin 9-oxo-octadecadienoic acid (9-oxoODE) & the ω-3 fatty acids eicosapentaenoic acid (EPA) & docosahexaenoic acid (DHA)
Endocannabinoid Tone and Oxylipins in Rheumatoid Arthritis and Osteoarthritis-A Novel Target for the Treatment of Pain and Inflammation?
https://pubmed.ncbi.nlm.nih.gov/40565171/
In tissue from osteoarthritic knees, higher pain levels were linked to lower levels of CB2 & 2-AG as well as higher levels of TRPV1
Opposing Synovial Cannabinoid Receptor Type 2 and Transient Receptor Potential Vanilloid 1 Expression in Painful Osteoarthritis
https://assets.cureus.com/uploads/original_article/pdf/403901/20250912-64459-bm0ldk.pdf
When PEA & field horsetail (Equisetum arvense) cause painkilling effects, an analysis of how they cross the blood-brain barrier to reduce oxidative stress, decrease pro-inflammatory cytokines & increase cell viability via the endocannabinoid system
Molecular Insights into the Nociceptive Modulation by Palmitoylethanolamide and Equisetum arvense Extract: An In Vitro Study Across the Blood-Brain Barrier
https://pubmed.ncbi.nlm.nih.gov/40573109/
❤️ The Heart & Blood ❤️
For plaque in your arteries, on creating cannabinoid nanoparticles targeted towards vascular cell adhesion molecule-1 (VCAM-1), “a well-established biomarker of atherosclerotic lesions”
Cannabinoid effective targeting of atherosclerotic plaques in vivo by optimized-PLGA nanoparticles
https://www.sciencedirect.com/science/article/pii/S0927776525005648
🍽️ The Guts, Metabolism & the Microbiome 🍽️
In people with pancreatitis, an analysis of their levels of using cigarettes & cannabis
Lifetime Smoking History and Marijuana co-use in Patients With Alcohol-related Acute Pancreatitis
https://pubmed.ncbi.nlm.nih.gov/40549965/
For obesity, a letter on the hurdles in using nabilone (a pharmaceutical cousin to THC)
Letter: Nabilone for the Treatment of Obesity: still Many Hurdles to Tackle
https://pubmed.ncbi.nlm.nih.gov/40526480/
For dentistry, a nano-CBD anti-inflammatory rinse
Biointelligent Dentistry: A Paradigm Shift
https://www.medtextpublications.com/open-access/biointelligent-dentistry-a-paradigm-shift-1826.pdf
And in people with moderate to severe inflammatory gum disease, this cannabinoid anti-inflammatory rinse decreased bleeding points
Dose Escalation Study: DenticDSTM Pair vs Placebo in Adult Patients with Gingivitis
https://www.medtextpublications.com/open-access/dose-escalation-study-denticdstm-pair-vs-placebo-in-adult-patients-1827.pdf
And a review of cannabinoid in dental health & disease
Review: BioIntelligent Dentistry - Modeling the Biological Mechanisms of Phytocannabinoids in Dental Health and Disease
https://www.medtextpublications.com/open-access/review-biointelligent-dentistry-modeling-the-biological-mechanisms-of-phytocannabinoids-1828.pdf
And a commentary on cannabinoids for dental care
Commentary: Cannabinoids for Collaborative Care
https://www.medtextpublications.com/open-access/commentary-cannabinoids-for-collaborative-care-1823.pdf
🩸 The Liver, Drug Interactions & Cannabinoid Metabolism 🩸
For liver transplants, this editorial stressed more flexibility for cannabis users
Cannabis and liver transplant: We need to chill, man
https://pubmed.ncbi.nlm.nih.gov/40539924/
💧 The Genitourinary System 💧
In a mouse model of kidney disease from tuberous sclerosis complex (a disorder of benign tumor growth), blocking the CB1 receptor in the body significantly reduced the hyperactivity of mTORC1 & the overexpression of c-Myc (cell growth & metabolism)
Targeting the endocannabinoid system to suppress mTORC1 hyperactivation in TSC-associated kidney disease
https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00097.2025
🖐️ The Skin & Topicals 🖐️
Analysis of a lip salve with hemp seed oil
Physiochemical and sensory assessment of lip salve formulation utilizing red microbial colourant from Talaromyces assiutensis, CPEF04 and supercritical carbon dioxide extracted hemp seed oil
https://www.researchsquare.com/article/rs-7507720/v1
For skin lesions from bacteria & for wound care, on creating a sprayable gel combining CBD, hyaluronic acid & colloidal silver
Sprayable Hybrid Gel with Cannabidiol, Hyaluronic Acid, and Colloidal Silver: A Multifunctional Approach for Skin Lesion Therapy
https://www.mdpi.com/1999-4923/17/9/1189
🎗️ Cancer & Chemotherapy 🎗️
In people with cancer, a survey found the majority thought medical cannabis helped with symptoms & and a minority thought it could cure the cancer itself
Perceptions, Uses, and Information Sources of Medical Cannabis Among Patients With Cancer
https://pubmed.ncbi.nlm.nih.gov/40546850/
In glioblastoma cells (the most aggressive brain cancer), CBC, CBG, CBD & Piper nigrum derivatives bound strongly to the targets GPR55 & PINK1, causing a cytotoxic effect
Evaluating the Antitumor Potential of Cannabichromene, Cannabigerol, and Related Compounds from Cannabis sativa and Piper nigrum Against Malignant Glioma: An In Silico to In Vitro Approach
https://pubmed.ncbi.nlm.nih.gov/40565152/
In pancreatic cancer cells, cannabis & CBD caused apoptosis (programmed cellular suicide)
Exploring the apoptosis-inducing potential of Cannabis sativa and cannabidiol in pancreatic cancer
https://www.researchsquare.com/article/rs-7098531/v1
In bone marrow cancer cells, CBD altered genes related to metabolism, the immune system & apoptosis (programmed cellular suicide)
Bioinformatics differential expression analysis of the effect of cannabidiol in chronic myeloid leukaemia cell line
https://www.sciencedirect.com/science/article/pii/S2699940425000773
In breast cancer, on using CBD camel milk exosomes
In Vivo Pharmacodynamic and Pharmacokinetic Assessment of Cannabidiol-loaded Camel Milk Exosomes in Doxorubicin-resistant Triple-negative Breast Cancer Xenografts
https://link.springer.com/article/10.1208/s12249-025-03201-9
💊 Synthetic Cannabinoids & Hemp-Derived Cannabinoids 💊
In Ireland, a survey of harms from HHC found the majority reporting negative consequences
Hexahydrocannabinol (HHC) use and harms in Ireland: New findings from the 2024 European Web Survey on Drugs
https://www.sciencedirect.com/science/article/pii/S095539592500307X
In vaping semi-synthetic cannabinoids, on the mechanisms behind the formation of toxic aerosols such as ketenes
Mechanistic Rationale for Toxic Aerosol Formation from Vaping and Dabbing with a Focus on Ketene Formation from Semi-Synthetic Cannabinoids
https://pdxscholar.library.pdx.edu/cgi/viewcontent.cgi?article=8041&context=open_access_etds
A potency analysis of semi-synthetic cannabinoid potency in vaping oils using LC-DAD-TOF
Potency Analysis of Semi-Synthetic Cannabinoids in Vaping Oils Using Liquid Chromatography Diode Array Detector with Electrospray Ionization Time-of-Flight Mass Spectrometry for Confirmation of Analyte Identity
https://pubmed.ncbi.nlm.nih.gov/40572560/
On analyzing illicit vape cartridges for synthetic cannabinoids
Analysis of cannabinoid-containing fluids in illicit vaping cartridges using a sequential TOF MS, DDA-MS/MS and DIA-MS/MS method
https://e-space.mmu.ac.uk/640152/2/ASMS2025.pdf
In mice, the pharmacokinetics & binding affinities of the synthetic cannabinoids 4F-MDMB-BINACA, 4F-MDMB-BICA & 5F-MDMB-PICA
Differential cannabinoid-like effects, receptor affinity and physiologically based pharmacokinetics of the synthetic cannabinoids 4F-MDMB-BINACA, 4F-MDMB-BICA and 5F-MDMB-PICA in mice: A comparative study
https://www.sciencedirect.com/science/article/abs/pii/S0041008X25003254
In mice, on the neurobehavioral effects of the CB1/CB2 agonist WIN55,212–2
A neurobehavioral evaluation of subcutaneously administered amphetamine, WIN55,212–2, 2,5-dimethoxy-4-Iodoamphetamine, and morphine in mice
https://www.sciencedirect.com/science/article/abs/pii/S1056871925002163
For HHC, structural analysis of why its 2 different epimers (stereoisomers, or “handedness”) have different binding affinities to the CB1 & CB2 receptors
Origin of the Different Binding Affinities of (9R)- and (9S)-Hexahydrocannabinol (HHC) for the CB1 and CB2 Cannabinoid Receptors
https://pubs.acs.org/doi/abs/10.1021/acschembio.5c00399
A rapid portable test for the synthetic cannabinoid ADB-butinaca
Portable electrochemical device for rapid and on-site forensic screening of synthetic cannabinoid ADB-butinaca: From laboratory development to real-world application
https://www.sciencedirect.com/science/article/abs/pii/S0925400525014856
On creating polymers to identify synthetic cannabinoids
Computational-Assisted Development of Molecularly Imprinted Polymers for Synthetic Cannabinoid Recognition
https://pubs.acs.org/doi/full/10.1021/acsomega.5c03148
On analyzing urine for hallucinogens, synthetic cathinones & synthetic cannabinoids using a LC-MS/MS
A Sensitive and Comprehensive LC‐MS/MS Method for the Analysis of Hallucinogens, Synthetic Cathinones, and Synthetic Cannabinoids in Urine Samples
https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdf/10.1002/jms.5178
🔬 Biochemical Discoveries & Research Tools 🔬
On creating very potent analogues to anandamide
Exceptionally Potent Chiral Anandamide Analogs
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5c02030
And if anandamide is our Great White Whale, that would make these be sperm whales with laser cannons, radar detection systems & enough intelligence to create industrial-scale giant squid butchery.
For CBD’s atomic conformational properties, an analysis of the impact of its hydrogen bonds on the observations in FTIR & NMR spectroscopy
Impact of O-H···π Hydrogen Bond on IR and NMR Parameters of Cannabidiol: Theoretical and Experimental Study
https://pubmed.ncbi.nlm.nih.gov/40572554/
On fluorinated ethers of cannabinol
Fluorinated Ethers of Cannabinol (CBN)
https://openurl.ebsco.com/EPDB%3Agcd%3A11%3A36827243/detailv2
On allosteric modulation of the CB1 receptor by ZCZ011
Allosteric Modulation of Cannabinoid Type 1 Receptor by ZCZ011: Integration of In Vitro Pharmacology and Molecular Dynamics Simulation
https://pubs.acs.org/doi/full/10.1021/acsbiomedchemau.5c00169
For membrane potassium channels, a thesis project on the effects of the endocannabinoids
Characterizing Lipid-Protein Interactions and Cellular Membrane Properties Using Computational Methods
https://ucalgary.scholaris.ca/items/704257de-386b-4ef8-a328-9fc2bdf2353f
Thanks.
- lex
PS: From the pioneering jazz soloist, the album ‘Sidney Bechet 1923-1936’. A master of the soprano saxophone & clarinet, Sidney Bechet helped to birth the improvisational nature of New Orlean jazz. As a child his talent on the clarinet developed so quickly that he was soon playing with some of the top bands in the city. By his 20s, he was on tour in Europe. It was there he found his first soprano saxophone in a store & it became his main instrument for the rest of his life. In 1919, the Swiss classical music conductor, Ernest Ansermet, wrote a Bechet tribute that was one of the earliest articles by a classical music expert on a figure from jazz, linking Bechet’s music with that of Bach. And Duke Ellington later called him “the epitome of jazz”.
Bechet’s recording debut was in 1923 (a few months before Louis Armstrong, as all the jazz historians note) & he spent much of the next years on the road, going as far as Russia & getting in as much trouble as a deportation from France (during a street brawl with fellow musicians, he pulled out his pistol, started shooting wildly & hit a couple of bystanders. He spent a year in jail, but funnily enough, when he returned to France in the late ‘40s, they loved him so much that he settled there for the rest of his life. They referred to him simply as ‘le dieu’” (the god)). In 1932, his hit recording of ‘Summertime’ took him to the top of the charts. By 1939, he was recording some of the earliest versions of what would be known as Latin jazz (incorporating méringue, rhumba & Haitian music into jazz). His dictated autobiography ‘Treat It Gentle’ is a staple of an insider’s view of early jazz, though Al Rose, who he dictated it to, said that he saw a different side of Bechet: “The kindly old gentleman in his book was filled with charity and compassion. The one I knew was self-centered, cold, and capable of the most atrocious cruelty, especially toward women.” Bechet died of lung cancer near Paris at the age of 62.
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