C&P#164: lots of helps & lots of harms & CBD for green macaws
Mortal blow for hemp in US + price dumping in Portugal
š This week š
Cannabis for Alzheimerās, glioblastomas, chronic musculoskeletal pain, multiple sclerosis & fibromyalgia
Harms: increased testicular germ cell tumors, worse lung function & psychosis risk in adolescents
Heart: 5x on heart harms + 50%+ increased stroke risk from daily cannabis use + CBD lowers blood pressure
A meta-analysis sez cannabis not helpful for sleep
Brain scans: cannabis good for HIV brains & CBDV good for autistic brains
Dentistry & cannabinoids!
Mixed results from this yearās Gastroenterology Meeting
CBD for green parrots with a feather-plucking disorder
Preclinical: data for Alzheimerās, type 2 diabetes, breast cancer, migraines & schizophrenia
K-popās āmarijuana shockā of 1975
(this weekās numbers: ~11,500 words, ~30 minutes reading time, 281 papers)
Hello everyone,
Welcome to the 164th edition of Cannabinoids & the People, Lex Pelgerās free weekly digest of all the new cannabinoid science, assorted canna-news & coverage of psychedelics, the War on Drugs & harm reduction. Support this work sharing canna-science with a paid subscription here.
As always, ask me anything!
š Editorās note š:
We just broke 7k subscribers. And I also broke my record for the number of papers processed for one newsletter: 281.
Unfortunately, Iām still behind in papers from my travels & that big research project ā and my carpal tunnel is starting to act up on me again pretty strongly ā but I feel blessed & invigorated to be able to spend my days watching such a fascinating array of cannabinoid science pass before my eyes.
So thanks to all of you for coming along for the ride!
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My Free How-To Guides on cannabinoids for different conditions. #AMA
My glossary of cannabinoid terms (& my Neural Ocean metaphor)
And as always, at the bottom is the album of the week: Piedmont blues
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āAnandamide; or, the Cannabinoidā: my cannabis graphic novel series (based on Moby Dick):
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- āThe CROWNā: the hunt for the chemical structure of CBN, the first fully-solved cannabinoid, as explained through elephants
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š„ My work this week š¤
Canna-Edu Vids for CV Sciences:
(on YT @CVSciencesInc & on TT @pluscbd)
[no new videos. still catching up from that big research project]
My š Vids:
(@LexPelgerAndHisBooks on TikTok, YouTube & Instagram)
š BEST OF CANNABINOID SCIENCE š
(most of the phytocannabinoid data is here & most of the ECS data is in the āCanna-Science Archiveā at the bottom)
āļø Clinical āļø
In older adults, public health data found current cannabis use not linked to harms in cognition & past use was linked to better performance & slower decline in some cognitive domains
History of cannabis use and cognitive function in older adults: findings from the UK biobank
https://academic.oup.com/ageing/article/54/11/afaf319/8313927
And in older adults with normal cognition, naturalistic cannabis use was linked to worse performance only on a few cognitive tests
The effects of naturalistic cannabis use on cognition and subjective experience in older adults with normal cognitive function
https://journals.sagepub.com/doi/abs/10.1177/02698811251370975
As we say often around here, weed for grandmas!
In people with Alzheimerās disease, a low-dose cannabis extract improved mental state & dementia
A randomized clinical trial of low-dose cannabis extract in Alzheimerās disease
https://pubmed.ncbi.nlm.nih.gov/41160460/
In people with cancer, those taking CBD had improved anxiety scores & those taking cannabis products had improved depression scores
Measuring the Effects of Cannabis on Anxiety and Depression Among Cancer Patients
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cam4.71342
In people with glioblastomas (the most aggressive brain cancer), potent antitumor effects were found from cannabinoid therapies, especially synthetic & THC-rich compounds
716eP Cannabinoids against glioblastoma: Consolidating the preclinical evidence for clinical translation
https://www.annalsofoncology.org/article/S0923-7534(25)02210-0/fulltext
For multiple sclerosis, the UK Medical Cannabis Registry found that treatment with cannabis-based medicinal products was associated with improvements in health-related quality of life
UK Medical Cannabis Registry: An Updated Analysis of Cannabis-Based Medicinal Products for Multiple Sclerosis
https://karger.com/mca/article-pdf/doi/10.1159/000549178/4460414/000549178.pdf
For chronic musculoskeletal pain, a meta-analysis of 5 trials found cannabis caused a significant reduction in pain intensity
Effectiveness of oromucosal medical Cannabis versus placebo in reducing chronic musculoskeletal pain: a systematic review and meta-analysis
https://www.researchgate.net/publication/397352491_Effectiveness_of_oromucosal_medical_Cannabis_versus_placebo_in_reducing_chronic_musculoskeletal_pain_a_systematic_review_and_meta-analysis
In people with fibromyalgia, THC significantly reduced spontaneous pain ratings
The impact of tetrahydrocannabinol on central pain modulation in chronic pain: a randomized clinical comparative study of offset analgesia and conditioned pain modulation in fibromyalgia
https://link.springer.com/article/10.1186/s42238-025-00348-x
In people with rare seizure disorders, CBD was effective & well-tolerated
Realāworld efficacy and safety of cannabidiol in developmental and epileptic encephalopathies
https://onlinelibrary.wiley.com/doi/pdf/10.1002/epi4.70149
In a case series of tuberous sclerosis complex (benign tumors that lead to seizures), for the two patients receiving CBD, one had a 50% reduction in seizures & the other became seizure-free after two months
Syndromic Manifestation of Tuberous Sclerosis: A Case Series
https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0045-1813164
In people with HIV, the cannabis users had a higher integrity of their default mode network
Neural Compensation in Persons with HIV and Marijuana use: Insights from a Reorganized DMN
https://watermark02.silverchair.com/netn.a.513.pdf
In brain scans of people with autism, CBDV altered their brain dynamics
Autistic brain dynamics and responsivity to multi-target pharmaco-challenge with Cannabidivarin (CBDV)
https://assets-eu.researchsquare.com/files/rs-7723564/v1/c1373bb6-8fa9-42ca-82d1-aa1d875b5c4f.pdf
In a green macaw parrot with feather-plucking disorder, CBD isolate did not reduce plucking behavior but did lower skin inflammation, helped mood & improved behavior towards partner & chicks
Reduction of Feather-Plucking Behavior in a Green Macaw (Ara militaris mexicanus) with Cannabidiol (CBD) Isolate (Clinical Case)
https://www.preprints.org/frontend/manuscript/e3d4aa3dbbec113167cc6bef32f9e718/download_pub
With a lack of CB2 receptors in parrots, they may require high doses of cannabinoids for clinical improvement.
I myself also credit CBD for less pulling out of my feathers as well as better behavior towards my partner & chicks.
ā¤ļø Heart Effects: Good & Bad ā¤ļø
For high blood pressure, 5 weeks of CBD reduced blood pressure levels
The effects of chronic cannabidiol dosing on cardiovascular parameters in primary hypertension: A summary of findings from a randomized controlled trial
https://academic.oup.com/eurheartj/article/46/Supplement_1/ehaf784.3321/8309303
For strokes, public health data found daily use of cannabis associated with ~50% increased odds, with risk decreasing as use frequency decreased
Is the Association of Cannabis Use and Stroke Frequency-Dependent: A Cross-Sectional Analysis of the NIH All of Us Research Program
https://journals.sagepub.com/doi/abs/10.1177/17474930251396481
For the increased heart rate from THC, light users were more sensitive to the effects, though tolerance developed more in heavy male users than in heavy female users
Abstract 4341683: Sex Differences in Acute Hemodynamic Response to Delta-9-Tetrahydrocannabinol Compared to Placebo: Impact of Cannabis Use Frequency
https://www.ahajournals.org/doi/abs/10.1161/circ.152.suppl_3.4341683
In young adults with acute coronary syndrome, those using cannabis had a 2.5x higher risk of major adverse cardiovascular events over the next 6 years
Cannabis use among young adults with acute coronary syndrome: impact on initial presentation and long-term prognosis
https://heart.bmj.com/content/early/2025/10/31/heartjnl-2025-326777
For young adults & coronary artery disease risk, a meta-analysis of 7 studies found a significantly higher incidence of coronary artery disease, but not an increased 10-year risk score
Association between consistent marijuana use among young adults and the risk of developing coronary artery diseases: a meta-analysis
https://academic.oup.com/eurheartj/article/46/Supplement_1/ehaf784.4236/8311418
In young cannabis smokers, they had increased risk signals for atherosclerosis (hardened arteries)
Abstract 4360838: Inhaled combusted cannabis use increases atherosclerosis risk in young people: A cross-sectional study
https://www.ahajournals.org/doi/abs/10.1161/circ.152.suppl_3.4360838
For medical cannabis & heart attack risk, public health data showed no increase within 30 days of use
Abstract 4370259: Medical Cannabis and Acute Myocardial Infarction Risk: A Case-Time-Control Analysis
https://www.ahajournals.org/doi/abs/10.1161/circ.152.suppl_3.4370259
For heart disease in people under 50, public health data found higher odds in cannabis users, with increased risk for higher frequency users
Assessing the association between cannabis use frequency and heart disease in adults aged under 50: National Survey on Drug Use and Health, 2021ā2023
https://www.sciencedirect.com/science/article/abs/pii/S009174352500221X
In people who had a blocked artery opened, those who used cannabis had higher rates of cardiogenic shock, congestive heart failure & anemia as well as a greater risk of congestive heart failure readmission at 6 months
The Effect of Marijuana Use on Outcomes Following PCI in an Urban Tertiary Care Center, An Updated Analysis
https://www.jacc.org/doi/abs/10.1016/j.jacc.2025.09.1291
A case report of a stroke in the large blood vessels of the brain linked to cannabis use
Cannabis-induced ischemic stroke involving the basilar and middle cerebral arteries in a 50-year-old man: a rare case report
https://academic.oup.com/omcr/article/2025/10/omaf205/8305647
In a mouse model of heart failure, CBD lowered scarring via the AGE-RAGE axis & genetic regulation of extracellular matrix collagen fibers
Abstract 4370383: Cannabidiol alleviates fibrosis through AGE-RAGE axis inhibition in a Non-Ischemic Mouse Model of Heart Failure
https://www.ahajournals.org/doi/abs/10.1161/circ.152.suppl_3.4370383
In a rat model of high blood pressure, CBG caused vasodilation & lowered blood pressure
Cannabigerol as a vasodilatory and blood pressure-lowering agent in spontaneously hypertensive rats
https://academic.oup.com/eurheartj/article/46/Supplement_1/ehaf784.4898/8308092
In a mouse model of heart damage from binge drinking, the gut microbiome modulated cardiac anandamide levels, leading to cardiovascular dysfunction
Selective Depletion of Gut Gram-Negative Bacteria Attenuates Alcohol Binge-Induced Cardiovascular Dysfunction by Lowering Cardiac Anandamide Levels
https://ajp.amjpathol.org/article/S0002-9440(25)00409-2/fulltext
American Journal of Gastroenterology 2025 Meeting
For people with cannabinoid hyperemesis syndrome, this review of patient encounters found standard antiemetics to be the most commonly used therapy, with only a small number of people receiving topical capsaicin or haloperidol (as recommended by existing guidelines)
Retrospective Analysis of Anti-Emetics Used for Cannabis Hyperemesis Syndrome to Assess Efficacy of Abortive Medications
https://journals.lww.com/ajg/fulltext/2025/10002/s1143_retrospective_analysis_of_anti_emetics_used.1144.aspx
In people with Crohnās disease, public health data showed that cannabis users had lower odds of hospital readmissions, smaller hospital costs & a shorter length of stay than the opioid users
Marijuana Use Is Associated With Reduced Health Care Burden Compared to Opioid Use in Inflammatory Bowel Disease: A Nationwide Study
https://journals.lww.com/ajg/fulltext/2025/10002/s1532_marijuana_use_is_associated_with_reduced.1533.aspx
In people with acute pancreatitis, public health data showed cannabis use could be protective, with decreased rates of mortality, ICU admission, respiratory distress, kidney injury & sepsis
Cannabis Use Is Associated With Better Outcomes in Patients With Acute Pancreatitis: A Propensity-Matched Analysis
https://journals.lww.com/ajg/fulltext/2025/10002/s259_cannabis_use_is_associated_with_better.260.aspx
In people with chronic gastrointestinal diseases, public health data found cannabis use linked to lower odds of sepsis (an overactive immune response to infection)
Association Between Marijuana Use and Sepsis in Patients With Chronic Gastrointestinal Diseases: A Cross-Sectional Analysis From All of Us
https://journals.lww.com/ajg/fulltext/2025/10002/s2114_association_between_marijuana_use_and_sepsis.2114.aspx
A case report where an initial diagnosis of cannabinoid hyperemesis syndrome turned out to be superior mesenteric artery syndrome (a blockage of the upper GI tract)
Superior Mesenteric Artery Syndrome Masquerading as Cannabinoid Hyperemesis: A Case of Diagnostic Delay
https://journals.lww.com/ajg/fulltext/2025/10002/s6012_superior_mesenteric_artery_syndrome.6011.aspx
In a case report of someone with type 1 diabetes, an initial diagnosis of cannabinoid hyperemesis syndrome turned out to be delayed gastric emptying & pyloric stenosis (a blocked sphincter at the bottom of the stomach)
Cannabinoid Hyperemesis Syndrome and Gastroparesis: A Complex Case Resolved With Endoscopic Pyloric Dilation
https://journals.lww.com/ajg/fulltext/2025/10002/s5290_cannabinoid_hyperemesis_syndrome_and.5289.aspx
In people with inflammatory bowel disease, public health data showed that cannabis users had lower odds of complications, but for Crohnās disease cannabis use was associated with longer hospital stays
Comparative Effects of Cigarette and Cannabis Smoking on Inflammatory Bowel Disease Complications and Outcomes: A Nationwide Analysis
https://journals.lww.com/ajg/fulltext/2025/10002/s1779_comparative_effects_of_cigarette_and.1780.aspx
In non-cirrhotic portal hypertension (a liver disorder of increased blood pressure), a case series of potential links to cannabis use
Idiopathic Non-Cirrhotic Portal Hypertension in Long-Term Marijuana Users: A Case Series
https://journals.lww.com/ajg/fulltext/2025/10002/s5396_idiopathic_non_cirrhotic_portal_hypertension.5395.aspx
In people with cirrhosis, public health data found those with cannabis use disorder had a higher risk of dehydration, sepsis, septic shock, pneumonia & acute kidney injury, while cannabis use was associated with higher odds of hospitalization, ER visits & mortality
Impact of Cannabis Use on the Outcomes of Liver Cirrhosis: A US National Retrospective Cohort Study
https://journals.lww.com/ajg/fulltext/2025/10002/s2393_impact_of_cannabis_use_on_the_outcomes_of.2393.aspx
In people with cirrhosis, those with cannabis use disorder had worse clinical outcomes, including increased mortality, ICU use, respiratory issues & electrolyte imbalance
Unmasking the Hidden Toll of Cannabis Use in Cirrhosis: A Real-World Analysis of Mortality, Critical Care Utilization, and Electrolyte Imbalance
https://journals.lww.com/ajg/fulltext/2025/10002/s2603_unmasking_the_hidden_toll_of_cannabis_use_in.2603.aspx
In people with gastroparesis (impaired stomach emptying), the cannabis users had a higher symptom burden & increased acute care utilization
Cannabis and Gastroparesis: Higher Symptom Burden and Greater Healthcare Use
https://journals.lww.com/ajg/fulltext/2025/10002/s3190_cannabis_and_gastroparesis__higher_symptom.3190.aspx
In people with kidney disease, CBD modulated the immune system with both pro- & anti-inflammatory effects
Cannabidiol Alters Circulating Lymphocytes Composition in a Concentration-Dependent Manner: A Single-Cell Study in Humans
https://journals.lww.com/jasn/fulltext/2025/10001/cannabidiol_alters_circulating_lymphocytes.2926.aspx
In a mouse model of kidney toxicity from cancer treatment with cisplatin, those without the DAGL enzyme (which synthesizes 2-AG) had better kidney scores, suggesting it as a therapeutic target
Genetic Deletion of Diacylglycerol Lipase-Ī±, an Endocannabinoid-Producing Enzyme, Protects Against Cisplatin-Induced Nephrotoxicity
https://journals.lww.com/jasn/fulltext/2025/10001/genetic_deletion_of_diacylglycerol_lipase__,_an.68.aspx
š Reviews š
For chemotherapy-induced nausea & vomiting, a review of 32 studies found significant benefits from cannabinoids
Cannabinoids for the prevention of chemotherapy-induced nausea and vomiting in oncological therapy: a systematic review
https://link.springer.com/article/10.1007/s11764-025-01876-4
In prostate cancer, a review of 12 studies on cannabinoids for pain & quality of life
Cannabinoids and Chemotherapy in Prostate Cancer: A Scoping Review of Evidence on Pain and Quality of Life
https://www.researchgate.net/publication/392660263_Cannabinoids_and_Chemotherapy_in_Prostate_Cancer_A_Scoping_Review_of_Evidence_on_Pain_and_Quality_of_Life
For cannabis & cognition in schizophrenia, a review of 15 studies found better cognition in some domains and worse cognition in other domains
Cannabis and Cognition in Schizophrenia: Systematic Review of Research Published from 2011 to 2024
https://link.springer.com/article/10.1007/s40429-025-00696-x/
In a review of substance use disorders & sleep, a review found cannabis may have acute sleep-enhancing effects at low doses, but that high doses & chronic use lead to sleep disturbances
Sleep Disturbances Across the Addiction Stages: A Review of Alcohol, Cannabis and their Co-Use
https://link.springer.com/article/10.1007/s40429-025-00681-4
For pediatric cannabis caregivers, a review on the importance of better storage & disposal to reduce unintentional pediatric cannabis ingestions
The Green Elephant in the Room: A Growing Need to Proactively Assess Cannabis Storage and Disposal Practices Among Pediatric Caregivers
https://www.sciencedirect.com/science/article/pii/S089152452500269X/
For palliative care, a review on the potential of cannabinoids
Use of cannabinoids in palliative care: an integrative review and bioethical view
https://www.researchgate.net/publication/396956190_Use_of_cannabinoids_in_palliative_care_an_integrative_review_and_bioethical_view
For diseases of the immune system, a review on the use of cannabinoids (nice charts)
Cannabinoids in immune system-related diseases: From bench to clinic
https://journals.lww.com/cmj/fulltext/9900/cannabinoids_in_immune_system_related_diseases_.1774.aspx
For Parkinsonās disease, a review of CBD
Cannabidiol and Parkinsonās disease: Investigating receptor interactions and their therapeutic implications
https://www.sciencedirect.com/science/article/abs/pii/S016372582500155X
For ADHD, a review on the potential of cannabinoids
Cannabinoids and ADHD: a New Frontier in Neuropharmacology?
https://link.springer.com/article/10.1007/s12031-025-02435-3
For skin conditions & CBD, a review found evidence for acne, dermatitis, psoriasis & potentially cosmetic purposes (nice charts)
The Therapeutic Potential of Cannabidiol in Skin Conditions
https://onlinelibrary.wiley.com/doi/pdf/10.1111/jocd.70527
And for diabetic foot ulcers, a review of 8 studies found hemp root hair extracts accelerated wound healing
THE EFFECT OF HEMP ROOT HAIR ON DIABETIC FOOT ULCER
https://journal.poltekkesaceh.ac.id/index.php/aich/article/view/1096/761
For dentistry & CBD, a review of 57 studies found anti-inflammatory properties & help for pain
Therapeutic Potential of Cannabidiol in Dentistry: A Systematic Review From Cellular Mechanisms to Clinical Trials
https://pubmed.ncbi.nlm.nih.gov/41194764/
And on CBD as an antibiotic in dentistry, a review of 10 studies found CBD showed promise against a range of oral bacteria & fungi
Potential Antimicrobial Use of Cannabidiol in Dentistry: A Scoping Review
https://www.mdpi.com/2304-6767/13/11/519
On PEA, a comprehensive review of its biochemistry & clinical evidence
Palmitoylethanolamide: A Comprehensive Review of Its Biochemistry, Therapeutic Applications, and Clinical Evidence
https://greg-cc.github.io/Health_Research/Palmitoylethanolamine/Palmitoylethanolamide:%20In-Depth%20Research%20Request.pdf
And for pain, a review on PEA (nice charts on how it works)
Palmitoylethanolamide in the Treatment of Pain and Its Clinical Application Prospects
https://www.tandfonline.com/doi/pdf/10.2147/DDDT.S540327
For the pharmacokinetics of THC & CBD, a review of how they move through the system depending on the ingestion route (very nice charts)
Perspectives of cannabis-based medicines in a view of pharmacokinetic studies of Ī9-THC and CBD in humans
https://www.sciencedirect.com/science/article/pii/S0753332225008674
For all the new cannabinoid drugs & their therapeutic potential, an excellent review
The development and therapeutic potential of classical and next-generation cannabinoid ligands
https://www.sciencedirect.com/science/article/pii/S1043661825004475
For the interspecies differences in cannabinoid receptors, a review at the tissue & cellular levels
Interspecies differences in the expression of cannabinoid receptors at the tissue and cellular levels
https://pubmed.ncbi.nlm.nih.gov/41169214/
ā ļø Harms ā ļø
For testicular germ cell tumor, a review of 5 studies on cannabis use as a significant risk factor
Cannabis use and risk of testicular germ cell tumour: a systematic review and metaāanalysis
https://bjui-journals.onlinelibrary.wiley.com/doi/abs/10.1111/bju.70062
For lung function, this excellently named study found cannabis smoking associated with worse respiratory symptoms, lower lung function, functional imaging abnormalities & dysregulated immune response in the airway lining
Clinical, physiologic, imaging, and molecular responses to cannabis smoking: the Canadian Users of Cannabis Smoke (CANUCK) Study
https://publications.ersnet.org/content/erj/early/2025/10/09/1399300301659-2025
Conversely, for cannabis & respiratory health, a combination of health insurance claims & survey data showed legalization linked to decreased asthma medication prescriptions & no changes to asthma outpatient visits or hospitalizations
Cannabis and Respiratory Health
https://www.nber.org/papers/w34435
And for COVID-19, people using cannabis or nicotine had increased frequency of symptoms & difficulty breathing
COVID-19 symptoms associated with smoking and vaping tobacco and cannabis: A cross-sectional analysis
https://www.sciencedirect.com/science/article/pii/S2211335525003304
For cannabis & sleep, a meta-analysis of 102 studies found cannabis use associated with poor sleep quality, less sleep duration, more insomnia symptoms & a later chronotype
Recreational cannabis use and sleep in the general population: a systematic review and meta-analysis
https://www.sciencedirect.com/science/article/pii/S108707922500142X
For psychosis risk in adolescents, this review found earlier & higher potency cannabis use linked to higher levels of psychotic experiences & their persistence into adulthood
High-Potency Cannabis, Early Use, and the Risk of Psychosis in Adolescents
https://hal.science/hal-05338009/
In Quebec young adults with a history of cannabis use, an earlier onset & more frequent use was linked to higher odds of medical care for mental disorders & physical health conditions, but no differences for late-onset users
Health Service Use Among Young Adults With a History of Adolescent Cannabis Use
https://pubmed.ncbi.nlm.nih.gov/41148134/
For people using medical cannabis or pharmaceutical cannabinoids, on the risks of psychosis & suicidality
Medicinal cannabinoid use and the risk of developing psychoses and suicidality
https://www.sciencedirect.com/science/article/pii/S246820202500035X
On cannabis poisoning cases in young children, analyzing emergency department data of the symptoms in 3,653 cases
Chief complaint, drug testing, and neuroimaging for cannabis poisoning in the emergency department
https://www.sciencedirect.com/science/article/abs/pii/S0735675725005418
A case report of two infants with accidental cannabis intoxication
Accidental Cannabis Intoxication in Two Young Children: Clinical Presentation and Toxicokinetics
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1695194/abstract
In a rat model of in-utero THC & CBD exposure, there was less fetal growth & placental health
Effect of In-Utero Cannabinoid Exposure on Foetal Growth and Placental Efficiency
https://annalsofhealthresearch.com/index.php/ahr/article/view/674
In a rat model of a single neonatal THC exposure, the females as young adults experienced a spatial memory deficit, but the males did not
Sexually Dimorphic Effects of a Single Neonatal Ī9-tetrahydrocannabinol Exposure on Neuronal Dendritic Morphology and Cognitive Functions in Rats
https://journals.sagepub.com/doi/full/10.1177/25785125251387835
In rats, oral THC enhanced the hedonic value of substances, leading to increased use of alcohol
Effects of Voluntary Ingestion of Synthetic Delta-9-Tetrahydrocannabinol on the Hedonic Value of Rewarding and Aversive Substances and CB1 Receptor Expression
https://www.liebertpub.com/doi/abs/10.1177/25785125251390206
In cannabis smoke, on the free radicals generated
Free Radicals in Cannabis Smoke
https://pubs.acs.org/doi/abs/10.1021/acs.chemrestox.5c00298
š Preclinical š
In a mouse model of Alzheimerās disease, CBD altered over 750 markers related to disease onset
Molecular pathogenesis of Alzheimerās disease onset in a mouse model: effects of cannabidiol treatment
https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2025.1667585/full
āThere were >1,000 differentially expressed markers of AD onset, whereby >75% were either eliminated or reversed in the direction of expression in response to CBD. Signaling pathways encompassed synaptic development and plasticity (e.g., Foxp2), neurovascular interactions (Smad9, Angptl6), receptors and ion channels (Gria4, Chrna2, Rgs7/Rgs7bp), mitochondrial genes (Ndufa7, Cox7a2), immunity (Ncr1), oxidation-reduction (Esr1), lipid synthesis (Fasn, ApoE), and carbohydrate metabolism (Mafa, Mlxipl).ā
In a mouse model of type 2 diabetes, hemp extracts reduced fasting blood glucose, improved glucose tolerance, reduced oxidative damage, regulated lipid metabolism & effectively alleviated damage to the liver, pancreas & kidneys
Preparation of cannabinoid extracts from hemp and their hypoglycemic effects
https://www.sciencedirect.com/science/article/abs/pii/S0254629925006167
In a female mouse model of breast cancer, cannabinoids lowered neuropathic pain & caused anti-tumor activity
Multifaced Roles of Cannabinoid Therapy in Cancer: Balancing Analgesia, Antitumor Potential, and Systemic Toxicity
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1691893/abstract
In a female rat model of migraines, on the benefits from various combinations of CBD, THC & CBG
Efficacy of different cannabinoid compounds on migraine-like responses in female rats
https://journals.sagepub.com/doi/pdf/10.1177/03331024251386794
In a mouse model of migraines, a 100:1 CBD:THC treatment improved light aversion, resting time & pain behaviors via CGRP levels
Cannabinoids rescue migraine symptoms caused by central CGRP administration in mice
https://journals.sagepub.com/doi/pdf/10.1177/03331024251392103/
In a rat model of schizophrenia, CBDV improved cognition & social deficits
The phytocannabinoid cannabidivarin alleviates cognitive and social behaviour deficits in the sub-chronic phencyclidine rat model of relevance for schizophrenia
https://journals.sagepub.com/doi/pdf/10.1177/02698811251381246
In a rat model of blood-brain loss due to stroke, the terpene beta-caryophyllene improved neurological functions & cognitive recovery via decreases in neutrophil extracellular traps, inflammation & oxidative stress
Ī²-Caryophyllene modulates the JAK2/STAT3 signaling pathway to downregulate neutrophil extracellular traps and alleviate cerebral ischemia-reperfusion injury
https://link.springer.com/article/10.1007/s11011-025-01723-6
In skin fibroblasts, the terpene beta-caryophyllene reduced oxidative stress
Beta-Caryophyllene Mitigates Oxidative Stress in Skin Fibroblasts by Targeting mTOR, Akt, and MAPK Signaling
https://link.springer.com/article/10.1007/s12013-025-01926-9
In a tissue model of Parkinsonās disease, cannabis extracts reduced alpha-synuclein formation
Cannabis sativa extracts reduce inclusion formation in a cell model of alpha-synuclein aggregation
https://www.sciencedirect.com/science/article/abs/pii/S0367326X25005945/
In innate immune cells, CBD caused anti-inflammatory effects via several pathways
Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators
https://repository.lsu.edu/cgi/viewcontent.cgi?article=6034&context=biosci_pubs
For killing nematodes & aphids, a metabolic analysis of cannabis leaves
Phytochemical, Nematicidal, and Aphidicidal Studies of the Leaves of Cannabis sativa L.
https://pubs.acs.org/doi/abs/10.1021/acsagscitech.5c00390
For terpenes & the cannabinoid receptors, an analysis of where they bind
Selective activation of cannabinoid receptors by cannabis terpenes
https://www.sciencedirect.com/science/article/pii/S0006295225007634
š Novel Studies š
(my grab bag section for stuff I havenāt quite seen before)
For San Francisco budtenders, a secret shopper approach for their answers on products to help with pain & sleep
Dispensing Medical Advice: San Francisco Bay Area Budtender Recommendations for Pain and Sleep Relief
https://publications.sciences.ucf.edu/cannabis/index.php/Cannabis/article/view/328/
āFor pain relief, budtenders showed a strong preference for topicals (77.1%), while edibles were most indicated for sleep trouble (60.0%). Reasons provided included budtender personal experience and product effectiveness. Cannabidiol (CBD) was endorsed most often for pain relief in high CBD:THC ratios (28.6%), 1:1 ratios (28.6%), and CBD alone (22.9%). For sleep relief, tetrahydrocannabidiol (THC) alone was most recommended (34.3%). When asked about cannabis strains for pain, 85.7% of budtenders did not express a preference, but for sleep, 57.1% of budtenders selected indica.ā
In the US, on the stigma against cannabis users
Stigma against Cannabis and Tobacco Users by Nonusers in the U.S.: The Role of Culture and Honor Values
https://www.sciencedirect.com/science/article/pii/S2666622725000243
And in role-playing of job hiring, the cannabis smokers had a hiring bias against them
CyberāVetted Behind the Smokescreen: The Evaluations of Cigarette and Cannabis Smokers in Hiring
https://onlinelibrary.wiley.com/doi/pdf/10.1111/ijsa.70027
I feel glad to be in a position where itād be weird if I wasnāt into cannabis.
In China, on quantifying the volatile organic compound emissions from hemp farming (a comparatively small 6.5 gigagrams, or 6,500 metric tons)
Crop-specific biogenic volatile organic compound emissions in China
https://www.sciencedirect.com/science/article/abs/pii/S1001074225005157
For swertisin (a primary ingredient in the traditional Chinese medicine Ziziphi Spinosae Semen), it upregulates levels of 2-AG & suppresses neuroinflammation & neuronal apoptosis (programmed cellular suicide) via the CB1 receptor & NF-ĪŗB pathway
Neuro-protection of swertisin against impairment induced by AĪ²25-35 by acting on COX-2 to up-regulate 2-AG and suppressing neuroinflammation
https://www.sciencedirect.com/science/article/abs/pii/S0304394025003180
š° US Headlines & Fav Articles š°
The US shutdown ended with Trump signing a bill that included recriminalizing hemp THC products one year from now (which he first approved in 2018)
https://www.marijuanamoment.net/congress-passes-bill-to-recriminalize-hemp-thc-products-sending-it-to-trumps-desk/
Now begins a huge push by the hemp industry to get this somehow changed before next yearās deadline.
Relatedly & perhaps outdatedly, for US hemp-derived THC beverages, an analysis of the federal & state gaps in regulation
Federal and state gaps in regulation of hemp-derived THC beverages
https://www.sciencedirect.com/science/article/abs/pii/S074937972500649X
On Veterans Day, Congress abandoned its efforts to let VA doctors recommend medical cannabis for veterans
https://www.marijuanamoment.net/congress-abandons-effort-to-let-va-doctors-recommend-medical-marijuana-on-veterans-day/
Curaleaf, in a particularly shoddy move, said their contract with Hello Farms isnāt enforceable because cannabis is federally illegal & thus contracts around it are unlawful
https://www.prnewswire.com/news-releases/hello-farms-v-curaleaf-appealed-to-us-court-of-appeals-for-the-sixth-circuit-302608963.html
In Los Angeles, cannabis shop owners have started a strike, refusing to pay taxes until the city cracks down on illegal sellers
https://www.foxnews.com/video/6384924373112
On the fall of Monterey County as Californiaās top cannabis-producing county
https://www.sfgate.com/cannabis/article/monterey-county-california-cannabis-decline-21141231.php
In Native American nations, an analysis of their varying cannabis possession laws
Tribal Marijuana Possession Laws: Prohibition to Legalization Among Native American Nations
https://www.sciencedirect.com/science/article/abs/pii/S0749379725005215
Heroic History Corner: on two veterans who fought for medical cannabis, Lynn Pierson & Steve Loup
https://aliceolearyrandall.substack.com/p/from-battlefield-to-bureaucracy-veterans
K-Pop History Corner: December 1975: The āmarijuana shockā where over 50 Korean pop musicians were arrested for cannabis use & disappeared from public eye overnight, unable to resume their careers for years
What Was āPopā in Korean Pop Before the K-pop 1964ā1987?
https://www.kci.go.kr/kciportal/landing/article.kci?arti_id=ART003247843
The same thing happen in US jazz under Anslinger. Iāll always remember my grandfather talking about Gene Krupaās career ruined by a reefer charge. And Anslingerās hounding of Billie Holiday into her grave will forever be a national disgrace.
Horrors History Corner: New testimony released on the CIAās drug mind control program, Project MKUltra, from its director Sidney Gottlieb
https://nsarchive.gwu.edu/briefing-book/dnsa-intelligence/2025-10-30/top-secret-testimony-cias-mkultra-chief-50-years-later
The book to read is āPoisoner in Chiefā by Stephen Kinzer.
And apparently, HBO is making a series on MKUltra by David Chase of Sopranos fame.
š International Updates š
In Portugal, allegations of price dumping (low-cost imports from overseas processed locally & shipped with a Portuguese label)
https://www.mmjdaily.com/article/9783113/allegations-of-price-dumping-cast-shadow-on-portugal-s-medical-cannabis/
āAccording to a person familiar with the matter, most of the cannabis that Portugal āexportsā is not grown in Portugal at all. Instead, large companies import low quality flower from overseas, process it locally, and then ship it back out with a Portugal flag stamped on the label. āPortugal has so far exported roughly 35 tonnes of medical cannabis flower,ā the source says. āOnly around 2 tonnes were cultivated here. The rest came from elsewhere.āā
In Australia, interviews about their medical cannabis program had the majority saying the current model was ānot fit for purposeā
From growers to patients: Multi-stakeholder views on the use of, and access to medicinal cannabis in Australia
https://d1wqtxts1xzle7.cloudfront.net/124791862/file-libre.pdf
In the UK, a parliamentary group published a new report on the emerging medical cannabis industry with a rather sane list of recommendations
https://internationalcbc.com/new-uk-report-highlights-untapped-cannabis-industry-potential/
In Germany, shortly after legalization, a survey on where people are sourcing their cannabis
Legal and Illegal Sources of Cannabis in Germany Shortly After Legalisation
https://link.springer.com/article/10.1007/s11469-025-01574-3
āAmong nā=ā1478 past-year cannabis users, 50.7% obtained some or all of their cannabis from legal sources. A majority reported a mix of legal and illegal sources (28.6%), predominantly social sources (20.5%) or predominantly illegal sources (15.0%). A minority of users obtained cannabis mostly from home-cultivation (13.5%) or pharmacies (12.3%), while some did not obtain but only co-used cannabis that someone else obtained (10.2%). Shortly after the cannabis reform, demand was mostly met by illegal sources.ā
In Thailand, an analysis of the cannabis growing community
Cannabis Growing Community Enterprise Initiative in Thailand
https://ideas.repec.org/a/bjx/jomwor/v2025y2025i4p217-230id630.html
In Rif, Morocco, an analysis of the effects of cannabis policy
Ecological dimensions of cannabis regulation in the Rif, Morocco
https://www.sciencedirect.com/science/article/abs/pii/S095539592500341X
In Nigeria, interviews about cannabis with NGOs, policy officials & people in the cannabis business
Drug policy stasis and hegemonic narratives of cannabis in Nigeria
https://www.sciencedirect.com/science/article/pii/S0955395925003366
In Brazil, a legal analysis found that the current model of dealing with possession of cannabis is not enough to prevent use
ANALYSIS OF THE TREATMENT GIVEN TO DRUG USERS BY THE BRAZILIAN CRIMINAL LAW: REFLECTION ON THE RECENT STF RULING IN RELATION TO THE SMALL POSSESSION OF MARIJUANA
https://openurl.ebsco.com/EPDB%3Agcd%3A8%3A20439912/detailv2?sid=ebsco%3Aplink%3Ascholar&id=ebsco%3Agcd%3A187153077&crl=c&link_origin=scholar.google.com
A wide-ranging ethnographic thesis project on global cannabis normalization through imagery & narratives
Cannabis and cultural accommodation: exploring online drug normalisation through global visual representations and social media narratives with reference to Portugal and the Netherlands
https://repository.canterbury.ac.uk/item/9w348/cannabis-and-cultural-accommodation-exploring-online-drug-normalisation-through-global-visual-representations-and-social-media-narratives-with-reference-to-portugal-and-the-netherlands/
āļø Business, Laws & Education āļø
For cannabis & public health, a Cochrane review on the different types of legislation
The protection of public health in the regulation of cannabis: a narrative review
https://revistanct.org.mx/en/2025-en/the-protection-of-public-health-in-the-regulation-of-cannabis-a-narrative-review/
For cannabis e-commerce platforms & womenās health, a market surveillance study of the benefit claims made
Characterization of Womenās Health Benefit Claims Made on Cannabis e-commerce Platforms: A Retrospective Market Surveillance Study
https://www.ajpmonline.org/article/S0749-3797(25)00651-8/abstract
For Chinese cannabis tourists in Thailand, a survey on their intentions & perceived risks
Understanding revisit Intention in Cannabis tourism: an extended TPB approach within the S-O-R framework
https://www.tandfonline.com/doi/abs/10.1080/13683500.2025.2542521
In the US hemp market, an analysis of the effects of shocks at different phases of the value chain
Pricing Dynamics in the US Hemp Market: A Vertical Price Transmission Analysis of the Hemp Value Chain
https://onlinelibrary.wiley.com/doi/pdf/10.1002/agr.70042
In tobacco shops of 3 US cities, 10% of them are also selling THC & CBD
Concurrent availability of cannabinoid and tobacco products in licensed tobacco retailers in three U.S. cities
https://www.sciencedirect.com/science/article/pii/S0955395925003378
š Driving š
For car crashes, cannabis legalization & dispensary openings had no significant impact on accident rates
Changes in Local Community Spatial Trends of Motor Vehicle Accidents Near Cannabis Dispensaries after Recreational Cannabis Legalization
https://www.liebertpub.com/doi/abs/10.1177/25785125251366791
After Canadian legalization in 2018, the police reported higher rates of impaired driving
Police-reported impaired driving after recreational cannabis legalization in Canada
https://www.sciencedirect.com/science/article/pii/S0749379725006440
For Australian police officers, a survey of the cues they use to assess driver intoxication from cannabis
What indicators do police officers use to detect intoxication? A survey of Australian police
https://www.tandfonline.com/doi/abs/10.1080/1068316X.2025.2582681/
For detecting driving after cannabis, on the potential of using the pupilās response to light as a biomarker of recent use
Functional Accelerated Failure Time Models for Predicting Time Since Cannabis Use
https://arxiv.org/abs/2510.22343
For driving under the influence of cannabinoids, Polish guidelines on conducting psychological tests
Standards for conducting psychological tests for driving under the influence of cannabinoids
https://yadda.icm.edu.pl/baztech/element/bwmeta1.element.baztech-50b0c804-af75-42ea-8172-8c492f429c12
For perceptions of impaired driving after cannabis, a survey on product frequency & associated behaviors
Road to risk: How different cannabis products affect perceptions of road safety and impaired driving
https://dspace.library.uvic.ca/items/2a25bdb5-cc35-4e67-9fc4-5d1db4be62f2
On driving after cannabis use, on using behavior economics to find cognitive biases
Pass the Keys: Using Behavioral Economics to Explore Driving After Cannabis Use
https://journals.sagepub.com/doi/abs/10.1177/29767342251360851
š The War on Drugs š
With 2 more strikes on alleged drug boats in the East Pacific, the US has now killed over 65 people
https://www.latintimes.com/us-has-now-killed-over-65-people-strikes-against-alleged-drug-boats-591324
And reporting on the men killed
https://jcpost.com/posts/08cc4a0a-4417-4084-8e2a-66766bd4cc39
https://www.aol.com/articles/reporter-found-she-investigated-us-125204756.html
And the UK ends US intelligence sharing because of the strikes
https://cbsaustin.com/news/nation-world/uk-stops-caribbean-intel-sharing-citing-us-militarys-illegal-drug-boat-strikes-report-vessels-bombing-narcotics-narco-terrorists-department-of-war-secretary-pete-hegseth-president-donald-trump
In changes to US federal sentencing guidelines, less emphasis will be put on the quantity of drugs & more on the role in the drug distribution chain
https://www.marijuanamoment.net/federal-officials-revise-sentencing-guidelines-for-drug-selling-convictions/
Seizures of khat up in the US
https://www.dailysignal.com/2025/11/08/spike-cbp-seizures-little-known-drug/
In the Sinaloa Cartel, on mapping their social networks
Social Embeddedness, Multiplexity, and Criminal Collaboration Within the Sinaloa Cartel
https://journals.sagepub.com/doi/pdf/10.1177/00224278251386040/
In Turkey after 1974, on how they reduced the diversion & cultivation of poppies
Beyond the ban: Explaining how Turkey reduced diversion and illicit poppy cultivation after 1974
https://www.sciencedirect.com/science/article/abs/pii/S0955395925003494/
On forensic identification of cannabis with plant DNA barcodes & cannabinoid synthesis genes
Forensic Identification of Cannabis with Plant DNA Barcodes and Cannabinoid Synthesis Genes
https://www.mdpi.com/2073-4425/16/11/1320/
On identifying cannabis in fingerprints with ToF-SIMS imaging
Application of ToF-SIMS to detection and imaging of cannabis-contaminated fingerprints - A preliminary study
https://pubmed.ncbi.nlm.nih.gov/41176961/
š”ļø Harm Reduction News š”ļø
In British Columbia, co-founders of the Drug User Liberation Front convicted on three counts of possession for the purpose of trafficking, despite the judgeās obvious sympathy to their harm reduction work on safer supply
https://drugdatadecoded.ca/court-finds-dulf-guilty-for-compassion-club-heralded-as-success/
In Toronto, the last supervised consumption site was defunded
https://datac.ca/ontario-provincial-government-defunds-torontos-last-supervised-consumption-site/
In Malaysia, experts warn that harm reduction is āstuck in heroin eraā
https://codeblue.galencentre.org/2025/11/malaysias-harm-reduction-stuck-in-heroin-era-as-ats-use-rises-panel-warns/
Michigan trying again to legalize its syringe programs
https://filtermag.org/michigan-bill-syringe-service-programs/
In Arizona, a path forward for drug injection sites after the governor vetoed a bill that would have prohibited local governments from allowing their development
https://azfreenews.com/2025/11/arizona-drug-injection-sites-have-path-forward-after-governor-hobbs-veto/
In Fargo, North Dakota, the City Commission voted to continue the cityās needle distribution program despite controversy after reports that glass pipes were being made available for drug users
https://www.valleynewslive.com/2025/11/11/fargo-city-commission-votes-continue-needle-distribution-program-despite-glass-pipe-controversy/
Harm Reduction Research
In interviews with people who inject drugs, on the links between early trauma, grief & coping
āWe Werenāt Taught How to Cope With Tragedyā: Early Childhood Trauma, Grief, and Learned Coping Mechanisms Among People Who Inject Drugs
https://pubmed.ncbi.nlm.nih.gov/41180077/
For peer workers in substance use recovery organizations, interviews on best practices for supporting them
A Qualitative Analysis of Organizational Practices to Support Peer Support Workers in The Substance Use Disorder Recovery Field
https://pubmed.ncbi.nlm.nih.gov/41188590/
On lessons for using telemedicine to give opioid agonist care within a community-based harm reduction service
Harnessing telemedicine to deliver patient-centered opioid agonist treatment within a community-based harm reduction service: a mixed methods evaluation
https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-025-01328-3/
For opioid & stimulant use disorders, a review on the current standard of care as well as emerging evidence for neuromodulation techniques, especially deep brain stimulation
Emerging neuromodulation treatments for opioid and stimulant use disorders
https://pubmed.ncbi.nlm.nih.gov/41164146/
In British Columbia, an analysis of their first year of drug decriminalization found significantly less drug possession incidents
Impact of the first year of British Columbiaās decriminalization of drug possession for personal use on drug crime in Canada
https://www.sciencedirect.com/science/article/abs/pii/S095539592500338X
In US correctional facilities, an analysis of the opioid overdose deaths that could have been avoided with expanded opioid use disorder treatment access
Potential health impacts of comprehensive access to opioid use disorder treatment in United States correctional facilities: A synthetic analysis
https://pubmed.ncbi.nlm.nih.gov/41185438/
For deaths in US immigration facilities, an analysis of gaps for identifying & treating substance use disorder
Substance Use Disorder and Substance Use-Related Mortality in US Immigration Detention (2018-2025)
https://pubmed.ncbi.nlm.nih.gov/41182848/
For the financial sustainability of hospital programs for opioid use disorder medications, interviews with hospital officials on costs
The Financial Sustainability of Programs to Initiate Medications for Opioid Use Disorder in Emergency Department Settings
https://pubmed.ncbi.nlm.nih.gov/41193942/
In recovery homes, interviews with directors on the complex barriers to housing residents on medication for opioid use disorder
āNow that weāve opened the doorā: challenges recovery home directors face when housing residents receiving medication for opioid use disorder
https://pubmed.ncbi.nlm.nih.gov/41188934/
In Rhode Island, on using machine learning to identify neighborhood overdose risk trajectories for harm reduction prioritization
Trajectories of neighborhood-level overdose risk predictions for prioritization of harm reduction services: Results from the PROVIDENT study
https://pubmed.ncbi.nlm.nih.gov/41175601/
For different types of substance use disorder treatment programs, a model on the transportation burdens
Estimation and Comparison of Travel Burden to Outpatient, Opioid Treatment Program, and Residential Substance Use Disorder Treatment Programs
https://pubmed.ncbi.nlm.nih.gov/41194519/
š Psychedelics, Plant Medicines & Other Psychoactives š
In the UK, ketamine at rock bottom prices: āTreated like table saltā
https://substack.com/home/post/p-176358981
š The Plant & its Products š
On the history of hemp textiles in ancient India
Hemp Textiles: Traditional Knowledge, Ayurveda and Fabric Utility in Ancient India
https://anubooks.com/uploads/special_issue_pdf/175378850312.%20Parul%20,%20Prof.%20Sonika%2084-89.pdf
š± Growing & Extracting š±
On using zinc sulfate & melatonin to improve hemp growth
Comprehensive analysis of hemp growth, physiological responses, and secondary metabolite production under zinc sulfate and melatonin treatments
https://www.sciencedirect.com/science/article/pii/S0926669025017224
For drought stress, on the responses of cannabis landrace seeds
Seed Germination Response of Various Cannabis Landraces to Polyethylene Glycol-Induced Drought Stress
https://link.springer.com/article/10.1007/s00344-025-11901-6
On improving cannabis drought tolerance by inoculation with Trichoderma hamatum (a fungus)
Enhancing drought tolerance in Cannabis sativa L. by Trichoderma hamatum through optimized water usage
https://www.sciencedirect.com/science/article/pii/S2214662825001021
A thesis project on using seaweed extract (Ascophyllum nodosum) to increase yield
An Analysis of Ascophyllum nodosum Extract on Yield and Cannabinoid Quality of Greenhouse Grown Cannabis sativa L.
https://ecommons.cornell.edu/items/de1c411a-2e01-427d-83cc-885a4c41f6e8
For cannabis light & nutrient management, a thesis on best practices
Using controlled environment agriculture to evaluate light and nutrient management strategies for Cannabis sativa L. and Fragaria Ć ananassa (Duchesne ex Rozier)
https://open.library.ubc.ca/soa/cIRcle/collections/ubctheses/24/items/1.0450535
For drying cannabis, a thesis project on solar drying technologies & optimizing drying kinetics
Advancing Sustainable Postharvest Processing of Floral Hemp through Solar Drying Technologies and Optimization of Drying Kinetics
https://escholarship.org/content/qt2w5586rd/qt2w5586rd.pdf
A thesis project on optimizing an indoor grow for yield
OPTIMISATION OF INDOOR CULTIVATION OF HEMP CANNABIS SATIVA L. TO INCREASE FLOWER AND CANNABINOID YIELD
https://www.fzt.jcu.cz/images/ZF/uredni-deska/studium/DSP/2025-neumann-autoreferat.pdf
On measuring plant cannabinoid levels with a compact handheld Raman spectrometer
Portable Raman Spectroscopy for NonāInvasive Chemotype Identification and pCB Profiling in Cannabis
https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jrs.70033
For a hemp genetic transformation method, this thesis project used a bacteria to alter traits for improved agronomy
Towards the improvement of hemp (Cannabis sativa L.) for agriculture
https://researchrepository.ucd.ie/entities/publication/e64324e0-a242-4bd8-98e1-098cb145912d
For the composition of hemp essential oils, on their changes across hydro-distillation periods
Essential oil fractions of hemp profiles at different hydro-distillation periods
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0331767
In cannabis germplasm, an analysis of genetic diversity across 83 genotypes
Molecular profiling and sex determination of Cannabis sativa germplasm collection: Exploring microsatellite markers and high-resolution melting (HRM) analysis
https://peerj.com/articles/19770/
On distinguishing cannabis from other plants with spectroscopic & chemometric tools
Discrimination of Cannabis sativa L. from other similar plant species using solvent extraction, ATR-FTIR and PLS-DA
https://www.sciencedirect.com/science/article/abs/pii/S2468170925000529
In Missouri, on the history of hemp & the current regulations
Industrial Hemp: History, Regulations & Licensing
https://extension.missouri.edu/publications/mx77
āļø Analyzing & Formulating āļø
On CBD chewing gum
Chewing Gum as a Delivery System for Cannabidiol: A Commentary
https://karger.com/mca/article-pdf/8/1/158/4418581/000547917.pdf
For hemp seed oil extraction, a comparison of techniques on yield & stability
Extraction technologies for hemp seed oil: a comparative study of yield, bioactive compound extractability, and oxidative stability
https://pubs.rsc.org/en/content/articlepdf/2025/fb/d5fb00424a
For CBD oil carriers, sunflower oil was found to be the most stable, with linseed & pumpkin seed oil having significant oxidative instability
Formulation and Analytical Evaluation of Liquid Cannabidiol Preparations: Comparative Study of Oil-Based Solutions and Emulsions
https://www.preprints.org/frontend/manuscript/7839ab914d33fa888900999bd17e64f4/download_pub
For increased CBD bioavailability, a review on using nanotechnology & advanced delivery systems
Innovative Strategies to Enhance the Bioavailability of Cannabidiol: Nanotechnology and Advanced Delivery Systems
https://www.mdpi.com/1424-8247/18/11/1637
For CBD mucosal permeation, on using liquid vehicles to increase absorption
In Vitro Release, Mucosal Permeation and Deposition of Cannabidiol from Liquisolid Systems: The Influence of Liquid Vehicles
https://d1wqtxts1xzle7.cloudfront.net/123772101/pdf-libre.pdf
On soy lecithin-based nanocarriers for cannabis extracts with photoprotective properties
SOY LECITHIN-BASED LIPID NANOCARRIERS FOR THE DELIVERY OF Cannabis sativa EXTRACT WITH PHOTOPROTECTIVE ACTIVITY
https://sciforum.net/manuscripts/25746/slides.pdf
On a fast annotation workflow for minor phytocannabinoids using Kendrick mass defect filtering
Kendrick Mass Defect Filtering Enables High-Throughput Untargeted Annotation of Minor Phytocannabinoids: Toward Streamlined Phytocannabinomics
https://pubs.acs.org/doi/full/10.1021/acsmeasuresciau.5c00106
š Food, Nutrition & Hemp Seeds š
On biscuits made from quinoa & hemp flower
Nutritional quality attributes, functional and sensory properties of biscuits produced from Quinoa (Chenopodium quinoa wild) and hemp (Cannabis sativa L) seed composite flour
https://www.emerald.com/nfs/article-abstract/doi/10.1108/NFS-08-2025-0273/1307522/Nutritional-quality-attributes-functional-and
On creating edible hemp protein films
Development of edible hemp protein films: Characterization and evaluation of their potential application in porridge oat production
https://sciforum.net/paper/view/25461
For probiotic hemp milk, a review of market growth
Probiotic hemp milk-market growth: An updated review
https://www.researchgate.net/publication/394448791_Probiotic_hemp_milk-market_growth_An_updated_review
In dairy cows being fed omega-3 fatty acids & tryptophan, they had changes to their endocannabinoid-related genes
The effects of N-acetyl tryptophan and omega-3 feeding during the transition period on relative expression of genes related to endocannabinoid system in adipose tissue of Holstein cows
https://archrazi.areeo.ac.ir/article_134206_9f7c15e93fc79d14218805d703663825.pdf
For hemp seeds, a chapter on their nutritional power (along with sunflower, pumpkin, chia & flax seeds)
Unleashing the nutritional power of sunflower seeds, pumpkin seeds, chia seeds, flaxseeds, and hemp seeds
https://www.sciencedirect.com/science/chapter/edited-volume/abs/pii/B9780443334887000035
šļø Industrial Uses & Fiber šļø
On producing biofuels with industrial hemp as a feedstock
Comparative Analysis of Pyrolysis-Based Biofuels: Hemp and Analogous Feedstocks
https://www.researchgate.net/publication/397267391_Comparative_Analysis_of_Pyrolysis-Based_Biofuels_Hemp_and_Analogous_Feedstocks
For supercapacitors, on creating porous carbon from hemp
Hemp-Derived Hierarchical Porous Carbon with an Optimized Pore Structure by NaOH Activation for Supercapacitor Applications
https://pubs.acs.org/doi/full/10.1021/acsomega.5c10175
In lead-contaminated soils, on improving hemp growth with vermicompost
Soil application of vermicompost modulates physiological and biochemical responses enhancing lead tolerance in hemp cultivated in lead-contaminated soils
https://www.sciencedirect.com/science/article/pii/S2772416625003304
On using hemp to clean soil of heavy metals
Sustainable Remediation of Heavy Metal-Contaminated Soil Using Industrial Hemp (Cannabis sativa L.)
https://d197for5662m48.cloudfront.net/documents/publicationstatus/272654/preprint_pdf/83c77c35817b863d135cae9ed2352459.pdf
For hemp grown in soil contaminated with ciprofloxacin, the majority of the antibiotic was pulled to above-ground structures of the plant by the time of full maturity
Physio-biochemical alterations and phytoremediation potential of hemp cultivated in ciprofloxacin (CIP)-contaminated soil: groundbreaking and enduring solution
https://link.springer.com/article/10.1007/s10532-025-10214-5
On absorbing methylene blue dye from water with magnetic carbon made from hemp hurd
Production of magnetic carbon adsorbents from hemp hurd: adsorption and kinetics of methylene blue dye removal
https://www.tandfonline.com/doi/full/10.1080/1536383X.2025.2573432
On wastewater treatment & heavy metal adsorption with hemp lignins
Sustainable Valorization of Hemp Lignin via Deep Eutectic Solvent Extraction and Amination for Enhanced Heavy Metal Adsorption and Advanced Wastewater Treatment Applications
https://link.springer.com/article/10.1007/s10924-025-03656-8
For 3D printing polymers strengthened with hemp, on an evaluation of their mechanical strength
3D Printing of Hemp-Reinforced Polylactic Acid and Acrylonitrile Styrene Acrylate Filaments: Mechanical Strength Evaluation
https://4spepublications.onlinelibrary.wiley.com/doi/abs/10.1002/pc.70564
For hemp-based pellets, a model of the production chain
Modelling and Sustainability Index Assessment of Biocomposites Supply Chain Networks Using Bayesian Belief Networks: A Case Study on Hemp-based Pellet Production
https://www.researchgate.net/publication/396350767_Modelling_and_Sustainability_Index_Assessment_of_Biocomposites_Supply_Chain_Networks_Using_Bayesian_Belief_Networks_A_Case_Study_on_Hemp-based_Pellet_Production
On hemp for paper production
Hemp as Bio Fiber Material for Paper Applications: Fiber Processing
https://hal.science/hal-05207507/
For hemp fiber, on the influence of alkali treatment & fiber percentage on strength & thermal conductivity
Influence of alkali treatment and fiber percentage on the mechanical and thermophysical properties of gypsum composites filled with hemp fiber
https://mpm.spbstu.ru/userfiles/files/Vol%2053%20No%203/7_devireddy_siva_bhaskara_rao_et_al.pdf
For epoxy composites with hemp, an analysis of their weathering properties
Lightweight InnegraāHemp/Epoxy Hybrid Composites: Effects of Weathering on Mechanical, Thermal, and Viscoelastic Properties
https://link.springer.com/article/10.1007/s12541-025-01377-5
For an epoxy composite with hemp fiber & silicon carbide, an analysis of its strength & moisture resistance
Hybrid hemp fiberāsilicon carbide reinforced epoxy composites: Enhancing mechanical strength and moisture resistance for sustainable applications
https://www.sciencedirect.com/science/article/pii/S2590123025040496
For hemp-lime concrete, a life cycle assessment
Life Cycle Assessment of Hemp-Lime Concrete: Analyzing Methodology and Environmental Impacts
https://link.springer.com/chapter/10.1007/978-3-031-97818-0_25
For lime hemp insulation, on its thermal & water behavior
Thermal Inertia and Hygrothermal Behaviour of a Hybrid FaƧade System With Lime Hemp Insulation: A Case Study
https://link.springer.com/chapter/10.1007/978-3-032-09054-6_32
Analysis of burning industrial hemp stems with polyvinyl chloride for resource recovery
Kinetic analysis and neural network-based prediction of TGA curves during the co-pyrolysis of industrial hemp waste and polyvinyl chloride
https://www.sciencedirect.com/science/article/abs/pii/S0165237025005169
šæ THE CANNA-SCIENCE ARCHIVE šæ
For hemp seeds in traditional Chinese medicine, a review on their pharmacological potential & quality control
Herbal Research, Phytochemistry, Pharmacology, Comprehensive Utilization, and Quality Control of Hemp Seed: A Comprehensive Review
https://pubmed.ncbi.nlm.nih.gov/40796348/
For Vijaya (the Ayurvedic name for cannabis), a detailed pharmacological analysis
Decoding Vijaya (Cannabis sativa L.) Leaves: A Comprehensive Analysis through Pharmacognosy, Physicochemical Profiling and Advanced Analytical Techniques
https://www.phcogres.com/article/2026/18/1/105530pres20262239
On the botany & diversity of cannabis, a review from China
Research Progress on the Botanical Characteristics and Diversity of Cannabis
https://www.hortherbpublisher.com/index.php/ijh/article/view/4038
A Ukrainian review of medical cannabis
GLOBAL EXPERIENCE WITH MEDICAL CANNABIS USE: INDICATIONS AND SAFETY PROFILE (literature review)
https://medpers.dmu.edu.ua/issues/2025/N3/220-230.pdf
š„ Public Health, Legalization Effects & Bioassays š„
In US adults, a survey found that those with more physically unhealthy days, mentally unhealthy days & functionally limited days were more likely to be using medical cannabis
Associations between cannabis use and self-rated quality of life among adults in the United States
https://www.tandfonline.com/doi/abs/10.1080/09687637.2025.2581696
In Israel, a survey on public attitudes towards medical cannabis diversion
Public Attitudes Toward Cases of Medical Cannabis Diversion: The Effects of participantsā And offenderās Gender
https://www.tandfonline.com/doi/abs/10.1080/01639625.2025.2547904
In South African medical students, a review on the impact of cannabis decriminalization
Decriminalization of cannabis use in South Africa: The perspectives and health outcomes among medical students; A systematic qualitative review
https://journals.sagepub.com/doi/pdf/10.1177/22799036251373016
In Saudi Arabia, on the knowledge of pharmacists about cannabinoid-based medications
The knowledge and attitude of pharmacists regarding the therapeutic use of cannabinoid-based medications in Jeddah, Saudi Arabia
https://journals.lww.com/md-journal/fulltext/2025/10310/the_knowledge_and_attitude_of_pharmacists.109.aspx
In Nigerian cannabis, testing found levels of cadmium high enough to be a public health concern
Potentially Toxic Elements in Local Cigarettes and Marijuana Leaves of Bauchi State, Nigeria: Public Health and Environmental Implications
https://www.mdpi.com/2673-4672/5/3/26
In Nigerian cannabis, only low levels of pesticides found
Risk assessment of organochlorine re pesticide recidue in Nigeria cannabis sativaL.
https://revues.imist.ma/index.php/AJEES/article/view/58186
In Libyan male cannabis smokers, a survey of their characteristics
Prevalence and Use of Cannabis Among Male Smokers in Zawia City, Libya: A Cross-Sectional Study
https://www.researchgate.net/publication/397014793_Prevalence_and_Use_of_Cannabis_Among_Male_Smokers_in_Zawia_City_Libya_A_Cross-Sectional_Study
On measuring blood levels of endocannabinoids with volumetric absorptive microsampling
Spotlight on Endocannabinoids in Healthy Individuals Using Volumetric Absorptive Microsampling Combined with LC-MS/MS Analysis
https://pubs.acs.org/doi/full/10.1021/acsomega.5c05574
On quantifying cannabinoids in blood with a bio-SPME LC-MS/MS method
A bio-SPME-LC-MS/MS method for the quantitative determination of cannabinoids in plasma samples: analytical strategy for optimization of matrix modification
https://link.springer.com/article/10.1007/s00216-025-06183-6/
On measuring 11 cannabinoids in blood using a UHPLCāMS method
An efficient and straightforward sample preparation for a sensitive, selective, and simultaneous determination of 11 phytocannabinoids in human serum using UHPLC-ESI-QTOF-MS/MS
https://www.sciencedirect.com/science/article/abs/pii/S0026265X2503348X
On identifying CBD metabolites by liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS)
Cannabidiol metabolites identified by LC-QTOF after controlled dosing
https://academic.oup.com/jat/advance-article-abstract/doi/10.1093/jat/bkaf098/8315145
š§ Adolescents & Young Adults š§
For people working with youth in Quebec on implementing their harm reduction program for cannabis use
Implementation and evaluation of a knowledge translation process to optimize the adoption of harm reduction in cannabis use by practitioners working with youth in Quebec: a mixed-methods study
https://link.springer.com/article/10.1186/s12961-025-01411-y
In US adolescents, public health data found THC or THC/CBD vaping might be associated with increased risk of depressive symptoms while CBD vaping may include a higher risk of anxiety
Cannabis vaping and mental health: The association of Īā9ātetrahydrocannabinol and cannabidiol with anxiety and depressive symptomsāFindings from the United States National Youth Tobacco Survey (2021ā2023)
https://onlinelibrary.wiley.com/doi/abs/10.1111/add.70218
In young adults with anxiety sensitivity, they are at increased risk for more frequent & problematic cannabis use
Emotional Psychopathology and Coping Cannabis Use Motives Are Involved in the Link Between Anxiety Sensitivity and Adverse Cannabis-Related Outcomes in Canadian Emerging Adults
https://www.tandfonline.com/doi/pdf/10.1080/10826084.2025.2570501/
For early cannabis initiation, predictive modeling of the associated social traits such as lower positive thinking during stress
Multi-level patterns predict cannabis use onset among youth
https://www.sciencedirect.com/science/article/pii/S1878929325001355/
For adolescents, social media influencers increased the odds of susceptibility to trying cannabis
E-cigarette and cannabis in social media influencer marketing and its effect on adolescents: a survey-based experiment
https://pubmed.ncbi.nlm.nih.gov/41182250/
In university students, higher cannabis use was linked to a lack of premeditation & perseverance
Impulsivity and its connection with cannabis use among college students: The case of the University of Veracruz
https://assets-eu.researchsquare.com/files/rs-7827697/v1/e10e8c3a-0f19-4818-bb76-9ae0875a70f5.pdf
In Southern California teens, higher perceived neighborhood disorder & greater objective disadvantage were linked with increased vaping levels
Prospective associations of subjective and objective neighborhood disadvantage with cannabis and nicotine vaping among Southern California adolescents
https://www.sciencedirect.com/science/article/abs/pii/S1353829225001674/
In young adults exposed to community violence & with PTSD symptoms, on the effects to their alcohol & cannabis use
Intersections of Community Violence Exposure, Posttraumatic Stress Symptoms, and Alcohol and Marijuana Use Among Young Adults
https://www.tandfonline.com/doi/abs/10.1080/10826084.2025.2575437/
In adolescents, interviews on why they found cannabis use more acceptable than alcohol
āIf You Need to Light Up ā¦ You Gotta Do What You Gotta Doā: A Qualitative Study of Adolescent Attitudes Towards Cannabis Use and Comparison with Alcohol Attitudes
https://www.researchgate.net/publication/396956789_If_You_Need_to_Light_Up_You_Gotta_Do_What_You_Gotta_Do_A_Qualitative_Study_of_Adolescent_Attitudes_Towards_Cannabis_Use_and_Comparison_with_Alcohol_Attitudes
In adolescents with diabetes, they used cannabis at about the same rate as those without diabetes
Exploring Substance Use Among Adolescents With Diabetes: A Retrospective Cross-sectional Analysis Using NSDUH Data
https://pmc.ncbi.nlm.nih.gov/articles/PMC12545280/
In Canadian youth in early psychosis care, self-reports found higher levels of cannabis use than the urine toxicology tests
Assessing the Concordance Between Self-Reported Cannabis Use and Urine Toxicology in Canadian Youth and Young Adults Attending an Early Psychosis Programme
https://www.mdpi.com/2673-5318/6/4/133
In Norwegian adolescents, a survey on who was willing to use drugs
The Role of SelfāReported Willingness to Use Drugs in Public Health Research: PopulationāLevel Projections of Adolescentsā Decriminalised Cannabis Use and Associated Risk Profiles
https://onlinelibrary.wiley.com/doi/abs/10.1111/dar.70061
In Canadian youth, a thesis surveying their motivations for using cannabis
Exploring postsecondary studentsā motivations for cannabis use
https://memorial.scholaris.ca/items/685c903c-1898-4ca5-a30f-19341d9bd440
For teens vaping nicotine & cannabis, a text message cessation intervention promoted abstinence
Dual abstinence from nicotine vaping and cannabis use among young people: secondary analyses from two U.S.-based randomized controlled trials of vaping cessation
https://link.springer.com/article/10.1186/s13011-025-00679-1/
In the adolescents of Catalonia, their cannabis use decreased during COVID, especially among girls
Changes in Alcohol, Cannabis, and Tobacco Use Before and After the COVID-19 Pandemic in Adolescents in Catalonia: A Repeated Cross-Sectional Study
https://www.mdpi.com/2813-2882/3/3/15
In high school seniors, a survey of their binge drinking & methods of ingesting cannabis
Multi-Modal Cannabis Use and Binge Drinking Outcomes Among 12th Grade Students in the United States, A Cross-Sectional Analysis from 2018-2021
https://www.tandfonline.com/doi/abs/10.1080/10826084.2025.2581244/
In US youth, cannabis use was associated with an increase in tobacco use
Cannabis use and progression to regular tobacco use among United States youth and young adults: evidence from the Population Assessment of Tobacco and Health (PATH) study, 2017ā2021
https://tobaccocontrol.bmj.com/content/early/2025/10/13/tc-2025-059634
In University of Mississippi students, a survey on their attitudes towards drug tourism
Drug Tourism and Youth: Legal Awareness, Attitudes, and Policy Implications for Mississippi
https://www.researchgate.net/publication/396973926_Drug_Tourism_and_Youth_Legal_Awareness_Attitudes_and_Policy_Implications_for_Mississippi
In Georgia, on the patterns of psychoactive use among young adults
PATTERNS OF CANNABINOID, HALLUCINOGEN, AND STIMULANT USE AMONG YOUNG ADULTS IN GEORGIA
https://bulgarian-journal-of-psychiatry.bg/wp-content/uploads/2025/11/BJP-4-25.pdf#page=24
š§ The Brain & Neurological Disorders š§
In brain scans of cannabis users after cannabis exposure, they had greater meso-striatal connectivity (dopamine pathways linked to reward processing)
Increased Mesostriatal Intrinsic Connectivity Associated With Cue Exposure in Adult Cannabis Users: Preliminary Findings
https://pubmed.ncbi.nlm.nih.gov/40776400/
In people with multiple sclerosis, they had possible early dysregulation of the endocannabinoid system
Dysregulation of the endocannabinoid system ā a key factor in the progression of multiple sclerosis?
https://medandlife.org/wp-content/uploads/JML-2025-0146.pdf
In central nervous system disorders, a review of targeting the endocannabinoid system
The Endocannabinoid System: Pharmacological Targets and Therapeutic Potential in CNS Disorders
https://pubmed.ncbi.nlm.nih.gov/41178765/
A review of medical cannabis & its effects on the developing brain
Under the Influence: Cognitive Effects of Medical Marijuana on Developing Minds
https://jppt.kglmeridian.com/view/journals/jppt/30/4/article-p440.xml
In a mouse model of Alzheimerās disease, a thesis project on targeting the endocannabinoid system
Exploring the molecular link between Alzheimerās disease and the endocannabinoid system
https://ddd.uab.cat/record/321668
In a computer model of Alzheimerās disease, CBDA bound to aquaporin 4 (a key regulator of brain water homeostasis & the clearance of amyloid-Ī² plaques)
Cannabis sativa Phytochemicals as Potent Regulators of Aquaporin-4 in Alzheimerās Disease: A Cheminformatics and Machine Learning Approach
https://link.springer.com/article/10.1007/s42250-025-01404-y
In a mouse model of memory, the CB1 receptors in the prefrontal cortex were involved in memory acquisition via the regulation of GABA (the brainās primary inhibitory neurotransmitter)
Cannabinoid type 1 receptors in the mice prefrontal cortex regulate object location memory acquisition via GABAergic neurons
https://link.springer.com/article/10.1186/s12993-025-00306-w
In a mouse model of spinal cord injury, an injectable hydrogel with CBD & fibroblast growth factor 21 modulated the balance between excitatory & inhibitory neurons, improved motor function & reduced inflammation via the microglia (guardian immune cells of the brain)
Local release of fibroblast growth factor 21 and cannabidiol promoting spinal cord nerve injury repair through activation of cannabinoid receptor 2
https://www.sciencedirect.com/science/article/abs/pii/S0142961225005289
In a mouse model of the rare seizure disorder Dravet syndrome, a thesis project analyzed the effects of cannabinoids on the lipid profile
An Investigation on the Lipidomic Profile of a Mouse Model of Dravet Syndrome and the Molecular Action of Cannabinoids
https://ses.library.usyd.edu.au/handle/2123/34478
In a mouse model of seizures, 2-Linoleoylglycerol reduced seizure activity via a serotonin receptor & the GPR55 receptor (which may one day be known as CB3)
2-Linoleoylglycerol decreased seizure through the regulation of 5-hydroxytryptamine 1A receptor and G protein-coupled receptor 55 interaction in mice
https://journals.lww.com/neuroreport/abstract/2025/12010/2_linoleoylglycerol_decreased_seizure_through_the.3.aspx
In astrocytes (the most predominant brain support cell), activating the CB1 receptor reduced connexin 43 (the most abundant connexin in the central nervous system)
CB1 Receptor Signaling Regulates Cx43 Hemichannel Trafficking and Phosphorylation in Astrocytes: Implications for Gliotransmission and Neuropathological Injury
https://www.researchsquare.com/article/rs-7238022/v1
In migrating neurons, on endocannabinoids & the cytoskeleton
The role of endocannabinoid signaling in the cytoskeleton functionality in migrating neurons
https://esmed.org/MRA/mra/article/view/7041
Glucose may be transformed into gallic acid, which then reacts with endocannabinoids to form neurotransmitters like dopamine or norepinephrine
Glucose may be biotransformed and then react with alcohol, fats, endocannabinoids, or various amino acids to form dopamine or norepinephrine in vivo
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1715092/full
š Mental Health, Addiction & Cannabis Use Disorder š
For problematic internet use & cannabis, a review of 7 studies found a potential link
Problematic internet use and cannabis consumption: A scoping review
https://www.sciencedirect.com/science/article/pii/S2211335525002499
In adult women, a survey on replacing alcohol with cannabis found it to be most likely among younger women as well as those with PTSD or sleep difficulties
Predictors of Replacing Alcohol With Cannabis Among Adult Women
https://assets.cureus.com/uploads/original_article/pdf/418147/20251031-187397-7u4ka4.pdf
In Moroccan adults with cannabis use disorder, interviews on the efficacy of family therapy
Family Therapy Effectiveness in Cannabis Use Disorder Among Moroccan Adults
http://www.ajopsy.com/wp-content/uploads/2025/06/Otman-Kaddouri-Aicha-Ziani-Family-Therapy-Effectiveness-in-Cannabis-Use-Disorder-among-Moroccan-Adults-Arab-Journal-of-Psychology-Vol-10-Issue-2-Summer-2025.pdf
During COVID, this thesis project found CBD reduced anxiety & negative emotional impact
Use of CBD Oil for Reducing the Negative Emotional Impact of COVID-19: A Randomized Clinical Trial
https://repositories.lib.utexas.edu/server/api/core/bitstreams/28b42ae5-34b8-48e4-b204-e8de9414e5db/content
On the link between sexual orientation & cannabis use, on the moderating effects of sexual assault history
Sexual Assault History Moderates Prospective Pathways From Sexual Orientation to Cannabis Use Outcomes
https://journals.sagepub.com/doi/abs/10.1177/08862605251361130
In sexual minority people, an obsessive passion for cannabis use was associated with more problematic use
Obsessive Passion for Cannabis Use is Associated with Cannabis Outcomes Among Sexual Minority College Students
https://www.tandfonline.com/doi/pdf/10.1080/10826084.2025.2579704
In US adults who experienced discrimination, they had higher links to psychotic experiences as well as cannabis use
Cannabis and Other Substance Use, Experiences of Ethnoracial Discrimination, and Psychotic-Like Experiences
https://academic.oup.com/schizophreniabulletin/advance-article-abstract/doi/10.1093/schbul/sbaf183/8305712
On sleep-wake rhythms, endocannabinoids & orexins
Endocannabinoids and Orexins in the Modulation of the Sleep-Wake Cycle and Substance Abuse
https://www.scielo.org.mx/scielo.php?pid=S0026-17422025000500008&script=sci_abstract&tlng=en
In Uruguay, a review of problematic cannabis use
Revision of regulations related to cannabis and problematic substance use
http://www.scielo.edu.uy/scielo.php
For reducing cannabis use, an online 2-week self-guided program
Back on track: Feasibility and efficacy randomized trial of a two-week online self-guided intervention for cannabis use reduction
https://www.sciencedirect.com/science/article/pii/S0376871625003965
In sexual minority women, on their attempts to quit cannabis & alcohol
Alcohol and cannabis cessation and reduction attempts and outcomes among sexual minority women and gender diverse individuals assigned female at birth
https://psycnet.apa.org/record/2026-80065-001
For quitting cannabis in California, on the racial & ethnic differences
Racial and ethnic differences in quitting when marijuana retail markets are legal: evidence from California
https://link.springer.com/article/10.1007/s00181-025-02802-4
In psychiatric patients in Eastern Nepal, on the demographics of cannabis users
Cannabis use and associated psychiatric morbidities among psychiatric outpatients of a teaching institute in Eastern Nepal
https://www.nepjol.info/index.php/JPAN/article/view/86009
For cigarette smokers, those who also used cannabis were more price-sensitive
Differential Responsiveness to Cigarette Prices by U.S. Adults Who Do and Do Not Use Cannabis
https://academic.oup.com/ntr/advance-article-abstract/doi/10.1093/ntr/ntaf205/8303885
On using voice signal analysis to identify drug addiction markers
Identification of Drug-addicted People using Short Length of Voice Signal through Haar and Symlet Wavelet Transform
https://gyaanarth.com/wp-content/uploads/2025/08/19-25.pdf
In a mouse model of autism, their cerebellar signaling was dysregulated via glutamate & cannabinoid receptors
Gestational VPA Exposure Impairs the Facial Stimulation-Induced Cerebellar MF-GC LTP by Enhancing mGluR1/5-CB1 Receptor Cascade in Offspring Mice
https://pubmed.ncbi.nlm.nih.gov/41157886/
In a rat model of sleep deprivation, higher levels of the brain growth factor BDNF were linked to more locomotor activity, higher pain threshold & more climbing via the CB1 receptor
The Effect of CB1r Hippocampal Activation on Behavioral Changes and BDNF Levels in Rapid-Eye Movement Sleep-Deprived Rats
https://pubmed.ncbi.nlm.nih.gov/40799146/
š§¬ Reproduction & Hormones š§¬
For maternal cannabis use disorder in Maine, a thesis on the trends in prevalence & demographics
Trends in Maternal Cannabis Use Disorder in Maine from 2016-2023
https://digitalcommons.usm.maine.edu/cgi/viewcontent.cgi?article=1183&context=muskie_capstones
For in-utero cannabis exposure, a review on the neonatal outcomes & developmental risk
Evidence on the effect of in-utero cannabis exposure in neonates
https://www.nature.com/articles/s41372-025-02383-1
For in-utero cannabis exposure, ā¦ something happened behind a paywall
Increasing in-utero cannabis exposure and the long-term academic and adaptive functioning of children
https://ebn.bmj.com/content/early/2025/10/27/ebnurs-2025-104307.abstract
š¦“ Pain, Musculoskeletal, Inflammation & Surgeries š¦“
Intriguing abstracts from the Irish Pain Society:
https://irishpainsociety.ie/wp-content/uploads/Irish-Pain-Society-25th-Annual-Scientific-Meeting-booklet-Final.pdf
In a rat model of lower back pain, on inhibiting the FAAH enzyme (which breaks down anandamide) & the MAGL enzyme (which breaks down 2-AG)
ANTINOCICEPTIVE EFFECTS OF FAAH OR MGL INHIBITION IN A PRECLINICAL MODEL OF LOW BACK PAIN
ā¦
In a rat model of a wound, CBD & CBG lowered pain-related behavior
ANTINOCICEPTIVE EFFECTS OF CANNABIDIOL AND CANNABIGEROL IN AN INCISIONAL WOUND MODEL
ā¦
In people experiencing thermal pain, their levels of PEA altered their sensitivity to thermal pain
BASELINE CIRCULATING ENDOCANNABINOID AND N-ACYLETHANOLAMINE LEVELS ARE ASSOCIATED WITH INDIVIDUAL DIFFERENCES IN HEAT PAIN SENSITIVITY IN HEALTHY INDIVIDUALS
In people using non-medical prescription opioids, they had higher blood levels of the endocannabinoid 2-AG after stress, while increased levels of 2-AG were associated with greater feelings of social inclusion
Endocannabinoid response to social stress in chronic non-medical prescription opioid users
https://link.springer.com/article/10.1007/s00213-025-06950-4
For pain, a review on the quest for new drugs to target the CB1 receptor
Advances in the Quest for Safe and Effective Drugs That Target the Cannabinoid Receptor Type 1 (CB1)
https://pubs.acs.org/doi/abs/10.1021/acsmedchemlett.5c00402
In a rat model of aerobic exercise & healthy food, they had enhanced physical performance & reduced CB1 receptors in the frontal cortex
Effect of physical training and palatable diet consumption on the expression of endocannabinoid system components in the rat brain
https://www.tandfonline.com/doi/abs/10.1080/1028415X.2025.2583391
In a mouse model of arthritis, the CB1 blocker Zevaquenabant lessened lung remodeling
Effects of cannabinoid receptor-1 antagonist MRI-1867 on C5ar1 signaling in attenuating lung remodeling in mice induced with experimental arthritis
https://www.sciencedirect.com/science/article/pii/S0171298525002189
On creating Cu-Zn-Se nanocomposites from cannabis & analyzing their antioxidant effects
Cannabis sativa-mediated biosynthesis of copper-zinc-selenium nanocomposites: phytochemical profiling, antioxidant properties, and molecular docking insights
https://link.springer.com/article/10.1186/s42238-025-00320-9
On delivering PEA to muscle cells with nanoparticles
Investigating Hybrid PLGA-Lipid Nanoparticles as an Innovative Delivery Tool for Palmitoylethanolamide to Muscle Cells
https://www.mdpi.com/1999-4923/17/11/1412
For sarcopenia (a muscle-wasting disease), a thesis project on creating a nanoparticle combining trimetazidine & PEA
Design and development of hybrid plga nanoparticles for the co-delivery of trimetazidine and palmitoylethanolamide for the treatment of sarcopenia
https://iris.unimore.it/handle/11380/1389400
For painkilling, esterifying pregabalin with PEA
Discovery of a long-acting nanocrystal formulation of INND-2201, a new co-drug of pregabalin and palmitoylethanolamide with synergistic analgesic effects
https://www.sciencedirect.com/science/article/pii/S2773216925000376
For pain, on FAAH inhibitors from aryl furan compounds
Design of arylfurans as potential FAAH inhibitors: therapeutic potential in pain management
https://www.sciencedirect.com/science/article/pii/S0968089625004122
A new peptide for pain control called MPN-12-NH2 worked via the CB1, opioid & neuropeptide FF receptors
MPN-12-NH2 shows potent antinociception effects by targeting opioid, cannabinoid, and neuropeptide FF receptors
https://www.sciencedirect.com/science/article/abs/pii/S0196978125001147
ā¤ļø The Heart & Blood ā¤ļø
In people with sickle cell anemia, they had no significant differences in the levels of cannabinoid receptors
EXPRESSION OF PTGER4, CNR1, AND CNR2 IN SICKLE CELL ANEMIA: INFLUENCE OF HYDROXYUREA AND HEMOLYSIS BIOMARKERS
https://www.sciencedirect.com/science/article/pii/S2531137925004122
A book chapter on the microvascular effects of cannabinoids
Microvascular Effects of Cannabinoids
https://link.springer.com/chapter/10.1007/978-3-031-99609-2_12
In heart endothelial cells & their endoplasmic reticulum (protein processing center), on the antioxidant effects of the endocannabinoids
A Protective Role for Endocannabinoids in Preventing Oxidative Stress in HCAECOxidative Stress in HCAEC
https://academic.oup.com/jes/article/9/Supplement_1/bvaf149.872/8299742
šØ The Lungs šØ
For lung injury, a review found that activating the CB2 receptor dampened inflammatory signaling & altered the macrophages (guardian immune cells)
Repolarization of inflammatory macrophages into reparative stage targeting cannabinoid receptor2: a potential perspective to dampen lung injury/ARDS
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1623857/full
š½ļø The Guts, Metabolism & the Microbiome š½ļø
In First Nations people of Canada, cannabis use was linked to poor oral health
Cannabis Use and Oral Health Among First Nations in Canada
https://www.sciencedirect.com/science/article/pii/S0020653925037268/
In young adults with cannabis use disorder, their oral microbiome had lower diversity & a higher abundance of anaerobes (bacteria not using oxygen)
Oral microbial profiles in young adults with cannabis use disorder
https://www.sciencedirect.com/science/article/pii/S0376871625002753
In adults with obesity, 30 mg of CBD did not alter their glucose tolerance or their gut microbiome
Short-Term Low Dose Cannabidiol Does Not Influence Glucose Tolerance or the Gut Microbiome in Sedentary Adults with Overweight and Obesity: Pilot Study
https://journals.sagepub.com/doi/full/10.1177/25785125251391085
In a rat model of decreased salivation and/or periodontitis (inflamed gum tissue), they had upregulated levels of the CB1 & CB2 receptors, suggesting them as a target
Upregulation of cannabinoid receptor gene expression in oral tissues subjected to hyposalivation and periodontitis
https://actaodontologicalat.com/wp-content/uploads/2025/10/aol_2025_38_2_112.pdf
In a rat model of arthritic pain in the jaws, the synthetic cannabinoid WIN-55,212-2 lowered the expression of inflammatory factors & reduced the secretion of inflammatory proteins
In Vitro Therapeutic Effect Of Win-55 On TMJOA
https://www.sciencedirect.com/science/article/pii/S0020653925052803
For antidiabetic effects, on the Ī±-glucosidase inhibitors in cannabis leaves
Ī±-Glucosidase Inhibitors from the Leaves of Cannabis sativa: StructureāActivity Relationship, Kinetic Investigation, and Molecular Docking
https://pubs.acs.org/doi/full/10.1021/acs.jafc.5c08443
For studying insulin release from the pancreatic beta-cells, on the synthetic cannabinoid azo-HU308 that can be turned on by UVA light
The photoswitchable cannabinoid azo-HU308 enables optical control of Ca2+ dynamics in INS-1 Ī²-cells via off-target effects on TRPC channels
https://pubmed.ncbi.nlm.nih.gov/41178137/
For obesity, developing CB1 receptor antagonists based on piperazines
Design and Evaluation of PiperazineāBased CB1 Antagonists as Promising Therapeutic Candidates for Obesity Treatment
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.202504557
š§ The Genitourinary System š§
In a genetic analysis of people with kidney damage from type 2 diabetes, certain variants of the CB1 receptor gene increased susceptibility to diabetic kidney injury
Association of cannabinoid gene polymorphism with neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1) in type 2 diabetes mellitus with chronic kidney disease
https://cellmolbiol.org/index.php/CMB/article/view/5908/3709
In a mouse model of kidney disease related to tuberous sclerosis complex (benign tumor growth), they had higher levels of CB1 & lower levels of CB2
Targeting the endocannabinoid system to suppress mTORC1 hyperactivation in TSC-associated kidney disease
https://journals.physiology.org/doi/prev/20250724-aop/abs/10.1152/ajprenal.00097.2025
š¦ The Immune System & Microbial š¦
In people with fibromyalgia, nursing consultations improved care but the majority were not offered cannabis as a therapy despite its availability
Symptom management, adherence to therapy, and filling the gaps of medical cannabis therapy: a qualitative study on the importance of nursing consultations for fibromyalgia patients
https://link.springer.com/article/10.1186/s42238-025-00346-z
For Japanese encephalitis virus (a neuroinflammatory virus), hemp root & stems cause antiviral effects, especially stigmasterol
Virucidal activity of Cannabis sativa L. (hemp) root and stem extracts against Japanese encephalitis virus: role of stigmasterol
https://link.springer.com/article/10.1007/s00705-025-06433-z
For the Chikungunya virus (which causes an inflammatory fever) in human immune cells, the synthetic cannabinoid WIN 55,212ā2 (but not CBD) reduced viral replication & macrophage inflammatory response
Synthetic cannabinoid WIN 55,212ā2 reduces CHIKV replication, modulates cytokine and chemokine production, and induces ER stress-related transcriptional responses in human monocyte-derived macrophages
https://www.sciencedirect.com/science/article/abs/pii/S1567576925017825
For antibiotics, on developing CBC derivatives
Design and synthesis of amphiphilic cannabichromene derivatives with antimicrobial potential
https://www.sciencedirect.com/science/article/abs/pii/S0045206825010648
šļø The Skin & Topicals šļø
For detecting heavy metals in topical CBD pain relief products, a thesis project on how to analyze their levels
Developing a Method for the Qualitative and Quantitative Analysis of Heavy Metals In Topical CBD Pain Relief Products
https://digitalcommons.newhaven.edu/masterstheses/244/
On protecting from chicken feather loss caused by the hormone dihydrotestosterone with hemp seed-derived exosomes
Hemp Seed-Derived Exosomes Protect Against Dihydrotestosterone-Induced Chicken Feather Growth Inhibition
https://www.mdpi.com/1424-8247/18/8/1192
šļø Cancer & Chemotherapy šļø
In cancer, a review of how the N-acylethanolamines (including the endocannabinoids) influenced cancer mechanisms
N-Acylethanolamines in cancer: mechanisms and therapeutic potential of lipid regulators of tumor behavior
https://www.sciencedirect.com/science/article/pii/S0163782725000402/
In triple-negative breast cancer cells, CBD caused anti-cancer effects & sensitized them to treatment
Cannabidiol sensitizes triple-negative breast cancer cells to NK cell-mediated killing via EGFR inhibition and FAS upregulation
https://link.springer.com/article/10.1186/s42238-025-00340-5
In colorectal cancer cells, the combination of CBD & the chemotherapy drug 5-fluorouracil delivered with liposomes caused anticancer effects including cell cycle arrest, reduction of cell viability & apoptosis (programmed cellular suicide)
Hyaluronic Acid-Functionalized Liposomes for Co-delivery of 5-Fluorouracil and Cannabidiol Against Colorectal Cancer
https://apb.tbzmed.ac.ir/Inpress/apb-43401.pdf
In glioblastoma cells (the most aggressive brain cancer), a combination of CBD & the NSAIDs celecoxib & 2,5-dimethylcelecoxib caused oxidative stress & apoptosis (programmed cellular suicide)
The Anti-Glioblastoma Effects of Novel Liposomal Formulations Loaded with Cannabidiol, Celecoxib, and 2,5-Dimethylcelecoxib
https://www.mdpi.com/1999-4923/17/8/1031
In ovarian cancer cells, cannabis extract reduced angiogenesis (new blood vessel formation)
Suppression of ovarian cancer-related angiogenesis processes by cannabis extract fraction in vascular endothelial cells is associated with reduced F-actin and focal adhesion points reorganization
https://www.sciencedirect.com/science/article/pii/S295019972500271X/
For ovarian cancer cells, on a nano-CBD delivery system via folate receptor binding
O-carboxymethyl chitosan-g-cholesterol derivative nanomicelles functionalized with folic acid for targeted cannabidiol delivery to ovarian cancer cells
https://link.springer.com/article/10.1007/s11051-025-06489-7
For pancreatic duct cancer detection, on using a PET probe for the CB2 receptor
Molecular Imaging of Pancreatic Duct Adenocarcinoma Using [Ā¹āøF]JR1004, a Cannabinoid Type 2 Receptor Targeted Positron Emission Tomography (PET) Probe
https://www.researchsquare.com/article/rs-7163014/v1
š Synthetic Cannabinoids & Hemp-Derived Cannabinoids š
For semi-synthetic cannabinoids in edibles in the EU, an analysis of their prevalence & problems according to public health alerts
From treat to threat: are semi-synthetic cannabinoids in edibles a new health concern?
https://www.croris.hr/crosbi/publikacija/prilog-skup/902104
For the metabolites of the major synthetic cannabinoids, an analysis of how they interact with the CB1 receptor
Structure-activity relationship of prevalent synthetic cannabinoid metabolites on hCB1 in vitro and in silico dynamics
https://www.nature.com/articles/s41401-025-01678-5
In mice, repeated injections of the synthetic cannabinoid AKB-48 caused neuroplasticity changes via serotonin in the cortex & cerebellum
Repeated administration of the synthetic cannabinoid AKB48 induces serotonergic neuroadaptation in male and female mice: behavioural and immunohistochemical evidence
https://www.sciencedirect.com/science/article/pii/S0028390825004666
For wastewater detection of synthetic cannabinoids in Mayotte, on the consumption patterns of local users
How synthetic cannabinoid user profiles and consumption patterns can affect wastewater-based epidemiology
https://link.springer.com/article/10.1007/s11356-025-37106-8
For wastewater analysis of synthetic cannabinoids, on using magnetic nanocomposites
Synthesis, characterization and application of oxidized multiwalled carbon nanotube/Fe3O4 nanocomposite for the magnetic solid phase micro-extraction of new synthetic ADB-FUBINACA and 5F-AB-FUPPYCA cannabinoids from various water samples
https://www.sciencedirect.com/science/article/abs/pii/S0026265X25033533
On detecting the synthetic cannabinoid 5F-ADB with ratiometric electrochemiluminescence
Signal-Inversion Strategy-Mediated Dual-Wavelength Ratiometric ECL Sensing for Sensitive Detection of 5F-ADB
https://pubs.acs.org/doi/abs/10.1021/acs.analchem.5c04591
On detecting the synthetic cannabinoid JWH-018 via through-space charge transfer
Electron-Donating/Accepting Group Modulation Enhanced Fluorescent Sensing of Synthetic Cannabinoid JWH-018 via Through-Space Charge Transfer
https://pubs.acs.org/doi/abs/10.1021/acs.analchem.5c02786
On rapid detection of synthetic cannabinoids in biological fluids with a SPE-LCāMS/MS method
Rapid SPE-LCāMS/MS Method for Detection and Quantification of MDMB-4en-PINACA and ADB-BUTINACA in Blood and Urine Using Solid-Phase Extraction
https://link.springer.com/article/10.1007/s10337-025-04451-2
š¬ Biochemical Discoveries & Research Tools š¬
For producing rare THC isomers from CBD, on optimizing a catalyzed cyclization method
Chemometric Optimization of BF3Ā·OEt2āMediated Cyclization of Cannabidiol to Rare Īā“ā and IsoāTHC Isomers
https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/chem.202502387
For this novel CB2 drug CB65, it demonstrated significant antifungal & anticancer activity
Multifaceted Evaluation of Anticancer, Antibacterial, Antifungal, and Anti-Candida Properties of Novel Cannabinoid Receptor 2 (CB2R) Ligands: An Integrated In Vitro and In Silico Analysis
https://sciforum.net/paper/view/25660
On new CB2 drugs based on chloro-benzo [d]imidazole
Synthesis of Novel Chloro-Benzo [d]imidazole Regioisomers as Selective CB2 Receptor Agonists: Indirect Functional Evaluation and Molecular Insights
https://www.mdpi.com/1424-8247/18/11/1599
On new CB2 agonists from carborane-based benzothiazole analogues
Development of Carborane-Based Benzothiazole Analogues as Cannabinoid Receptor Type 2 (CB2R) Ligands
https://pubs.acs.org/doi/full/10.1021/acsomega.5c06508
On quinoxaline & quinoline carboxamides as allosteric modulators of cannabinoid receptors
Discovery and characterization of quinoxaline and quinoline carboxamides as allosteric cannabinoid receptor modulators
https://www.sciencedirect.com/science/article/pii/S0006295225007506
A thesis project on creating probes for mapping the endocannabinoid system proteome
The Synthesis of a Photo-Affinity Probe Library for the Fatty Acid Amide Proteome and the Endocannabinoid System Within
https://www.proquest.com/openview/49e6ae272d3067c2322952473ad849aa/1
Thanks.
- lex
PS: For todayās Piedmont/East Coast blues album, āCarolina Bluesā by Guitar Slim & Jelly Belly. Guitar Slim, born Alec Seward, grew up in Virginia while Jelly Belly (aka Louis āFat Boyā Hayes) hailed from North Carolina. They both moved to NYC & recorded this album in 1944. Guitar Slim went on to record with many of the greats like Lead Belly, Sonny Terry & Woody Guthrie while Jelly Belly moved into a life in the ministry. With its fingerpicking & singing, this acetate album was seen as one of the last outposts of country blues before the rise of Chicago & Detroit.
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