C&P#168: goods for fibro, sleep & female chronic pain, bads for heart & psychosis, mixed for suicide
Schedule III maybe?
🌟 This week 🌟
Cannabis for fibro + sleep
Tailored cannabis for women with chronic pain syndromes (Brazil rocks)
Decreased suicides of older adults when states opened dispensaries
Case reports: one fatal heart attack + one case of psychosis after stopping cannabis + one teen with cannabis-induced psychosis
In high schoolers, cannabis linked to a doubled risk of suicide
The Journal of Christian Nursing decided to go pro-cannabis, like Jesus would have wanted
Preclinical: inhaled CBD for Alzheimer’s + OEA for kidneys + CBD for HIV
4x on psychedelics causing persistent altered states (scary stuff)
Psychedelics & prostate cancer?
DEA & CUMYL-PEGACLONE
For pain in your dairy calves, injectable liposomal CBD
(this week’s numbers: ~10,000 words, ~26 minutes reading time, 196 papers)
Hello everyone,
Welcome to the 168th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news & coverage of psychedelics, the War on Drugs & harm reduction. Support this work sharing canna-science with a paid subscription here.
As always, ask me anything!
📌 Editor’s notes 📌:
Since I’m a drug writer at heart, you’ll notice more science coverage around here of ketamine, the cathinones, psychedelics, kava & kratom. They’re just so damn interesting…
I did not win an EmJay, but props to Rachelle Gordon who most certainly deserves her win for her canna-coverage at GreenState.
Thanks to friend of the newsletter Elizabeth Moriarty of Luminary Medicine for becoming a paid supporter of Cannabinoids & the People & for her Good Work of getting fine medicines out into the world. If you’d like to support this free canna-science newsletter as well, you can become a paid subscriber here.
And thanks to Belle Paniagua-Novak for buying me a coffee this week. It feels akin to the Alfréd Rényi quote , “A mathematician is a device for turning coffee into theorems.” Except I’m a machine for turning green tea & canna-science into content.
🤝 Sponsor 🤝: The Cannabis & Health Research Initiative
Want to help expand the knowledge of medical cannabis use in the real world & get paid 100 bucks to do so?
Johns Hopkins University, with support from Realm of Caring, is spearheading the groundbreaking National Cannabis Study to evaluate the benefits, risks & overall outcomes of using cannabis for conditions like pain, insomnia, anxiety & more. If you are an adult in the U.S. considering starting cannabis for health reasons, this is your chance to help shape the future of cannabis research — and get compensated for your time ($100!). Join now to share your experience & contribute valuable data that could revolutionize healthcare for many patients nationwide. To learn more & sign up, visit:
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Follow along on Instagram to keep on learning or sign up for the monthly CHRI email (curated by me) to get just the best of clinical research & new reviews twice a month.
🧰 Free resources 🧰
CVResearch.info: the extensive cannabinoid science archive I maintain for CV Sciences
Canna-edu videos: on YouTube @CVScienceInc & on TikTok @pluscbd (backup account @cannabinoidsandthepeople)
My Free How-To Guides on cannabinoids for different conditions. #AMA
My glossary of cannabinoid terms (& my Neural Ocean metaphor)
And as always, at the bottom is the album of the week: Wild Women of early rock
🐋 For more from Lex… 🐋 | my Linktree |
‘Anandamide; or, the Cannabinoid’: my cannabis graphic novel series (based on Moby Dick):
First 2 seasons of my podcast ‘The Lex Files’ on cannabinoids, psychedelics & spirituality
Work with my company White Whale Creations to produce cannabis content: writing, science archives, social media, newsletters & podcasts: my portfolio
📣 A request to spread the word 📣
This newsletter only spreads by word of mouth, so please forward to friends & colleagues.
🎥 My work this week 🎤
Canna-Edu Vids for CV Sciences:
(on YT @CVSciencesInc & on TT @pluscbd)
[no new videos. still catching up from that big research project]
My 📚 Vids:
(@LexPelgerAndHisBooks on TikTok, YouTube & Instagram)
Anticipation in ‘The Huainanzi’ + How to be a hero to the world
from Whitman’s Leaves of Grass ‘To Think of Time‘
🍃 BEST OF CANNABINOID SCIENCE 🍃
(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)
For your canna-science visuals, the Cannabis Periodic Table of Molecules
https://acannability.com/periodictable/#periodicTable
For how scientists identify a cannabis user, a review by Dr. Ruth Fisher
What is a “Cannabis User”?
https://www.sciencedirect.com/science/article/abs/pii/S014929182500387X
For cannabis researchers, on lessons that can be learned from tobacco research
New Approaches to Historical Challenges: Avoiding the Early Missteps of Tobacco Research in Cannabis Studies
https://www.sciencedirect.com/science/article/abs/pii/S2468202025000488
For CBD and cosmetic products, the EU has a new scientific opinion that considers levels up to 0.19% CBD to be safe & the max level of THC “impurities” to be 0.00025%
SCCS - Scientific Opinion on Cannabidiol (CBD) (CAS/EC No. 13956-29- 1/ 689-176-3) used in cosmetic products
https://health.ec.europa.eu/publications/sccs-scientific-opinion-cannabidiol-cbd-casec-no-13956-29-1-689-176-3-used-cosmetic-products_en
⚕️ Clinical ⚕️
In women with chronic pain syndromes, an excellent Brazilian study of full-spectrum cannabis extracts with tailored dosages found improvements in pain relief, cognitive function, motor abilities, professional activities & ability, irritability, anxiety, melancholy, fatigue & sleep quality
Full-spectrum cannabis extracts for women with chronic pain syndromes: a real-life retrospective report of multi-symptomatic benefits after treatment with individually tailored dosage schemes
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1538518/full
In my opinion, Brazil continues to lead the world in practical studies about how to actually use cannabis. While so many places flounder around killing mice & looking at single cannabinoids altering biochemical markers, the Brazilians are looking at the actual compositions of cannabis extracts that most help patients with complex conditions like chronic pain syndromes.
For fibromyalgia, data from the UK Medical Cannabis Registry found cannabis-based medicinal products improved all measures of symptom severity, pain, anxiety & sleep
UK Medical Cannabis Registry: a case series analysing clinical outcomes of medicinal cannabis therapy for fibromyalgia
https://link.springer.com/article/10.1007/s10067-025-07846-6
In people with chronic kidney disease, interviews on how they use cannabinoids to relieve symptoms & on their barriers to use
Patients’ Perspectives and Experiences of Cannabinoids to Manage Symptoms of Chronic Kidney Disease: An In-Depth Interview Study
https://pubmed.ncbi.nlm.nih.gov/41346017/
In people with chronic pain, joining the New York medical cannabis program was associated with significantly reduced opioid prescriptions
Medical Cannabis and Opioid Receipt Among Adults With Chronic Pain
https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2842414
In people with poor sleep, this meta-analysis of six trials found cannabinoids significantly improved sleep quality, especially the non-CBD cannabinoids
Effectiveness of cannabinoids on subjective sleep quality in people with and without insomnia or poor sleep: A systematic review and meta-analysis of randomised studies
https://www.sciencedirect.com/science/article/abs/pii/S1087079225001091
This always throws people, because in every survey on why people use CBD, insomnia is always in the top 3 reasons. But CBD isolate, especially at high doses, tends to wake people up & be alerting. My hypothesis is that at low doses, CBD may be helping some people with their anxiety around going to sleep, while for other people, what they’re actually doing is microdosing on the THC found in a full-spectrum hemp extract – and that’s very helpful for sleep.
But if anything is known about cannabinoids & sleep, it’s that everyone is different. Find what works for you!
(or just don’t have kids & sleep all you want)
For children & adolescents with autism, a meta-analysis of 4 studies on the efficacy of CBD [Portuguese]
Use of cannabidiol in children and adolescents with autism spectrum disorder: a scoping review
https://revistas.pucsp.br/index.php/dic/article/view/72186/48977
For people with cystic fibrosis, public health data found that cannabis use disorder was not associated with 30-day readmission
ASSOCIATION OF CANNABIS USE DISORDER WITH 30-DAY READMISSION RISK IN CYSTIC FIBROSIS EXACERBATION: A NATIONWIDE ANALYSIS
https://journal.chestnet.org/article/S0012-3692(25)02912-5/fulltext
In people with bipolar disorder, their cannabis use had no effect on their average length of hospital admission
Length of hospital admission, cannabis use and associated factors in patients with bipolar disorder
https://sajp.org.za/index.php/sajp/article/view/2510
A survey of why U.S. adults are using CBD, CBN, CBG, HHC & delta-8 THC
Prevalence and reasons for using cannabidiol, delta-8 tetrahydrocannabinol, cannabinol, cannabigerol, and hexahydrocannabinol among US adults
https://link.springer.com/article/10.1186/s42238-025-00359-8
For suicide in older adults, the National Bureau of Economic Research found that the opening of adult-use cannabis dispensaries decreased suicide rates
Marijuana Legalization and Suicides Among Older Adults
https://www.nber.org/papers/w34519
In a Dutch survey of non-prescribed medical cannabis use, the most common conditions were chronic pain, sleep disorders, depression & ADHD/ADD
Medicinal use of non-prescribed cannabis: a cross-sectional survey on patterns of use, motives for use, and treatment access in the Netherlands
https://link.springer.com/article/10.1186/s42238-025-00355-y
“Most participants obtained cannabis from coffeeshops, although one in four also reported home cultivation as a source. Participants typically smoked cannabis with tobacco, reported (near-)daily use for therapeutic purposes, and indicated a monthly expenditure of €100. The majority was not aware of the THC and CBD content of their products. Perceived effectiveness was rated as high, and more than half of those with a history of prescription medication use reported substituting cannabis for these medications.”
For severe pain in mast cell activation syndrome, a case report of using CBD combined with the muscle relaxant orphenadrine
A Treatment Approach for Severe Pain in Mast Cell Activation Syndrome: A Case Report
https://journals.lww.com/aacr/abstract/2025/12000/a_treatment_approach_for_severe_pain_in_mast_cell.20.aspx
In dogs with eczema, a combination of PEA & polyunsaturated fatty acids decreased itchiness & skin lesion severity
Clinical evaluation of polyunsaturated fatty acids in combination with palmitoylethanolamide (PEA) in the treatment of signs of atopic dermatitis in dogs:Pilot study
http://www.medycynawet.edu.pl/images/stories/pdf/pdf2025/122025/2025127051.pdf
In dairy calves, on the injection of liposomal synthetic CBD as a painkiller
Pharmacokinetics and tolerability of liposomal synthetic cannabidiol subcutaneous depot in Holstein dairy calves
https://www.sciencedirect.com/science/article/pii/S0022030225010008
📑 Reviews 📑
On the toxicology of Epidiolex (a pharmaceutical CBD), a big review by its maker Jazz Pharmaceuticals
An Overview of the Nonclinical Toxicology of CBD-OS, the First Approved Therapeutic Cannabidiol
https://www.sciencedirect.com/science/article/abs/pii/S2468202025000373
On cannabinoids for mental health & substance use disorders, a review of 28 studies found short-term benefits for autism, schizophrenia & cannabis use disorder
Randomised Controlled Trial Evidence on Medicinal Cannabis for Treatment of Mental Health and Substance Use Disorders: A Scoping Review
https://link.springer.com/article/10.1007/s40261-025-01501-3
In prodromal psychosis (initial symptoms), a review of 22 studies on the ECS as a therapeutic target
The endocannabinoid system as a therapeutic target in prodromal psychosis: From molecular mechanisms to clinical applications
https://journals.sagepub.com/doi/abs/10.1177/02698811251389574
In the genital & lower urinary tract, a review on the endocannabinoids & receptors located there
The significance of endocannabinoid receptors and endocannabinoids in the lower urinary and genital tract
https://link.springer.com/article/10.1007/s00345-025-06045-x
For cardiovascular health, a review on dietary hemp seeds
Dietary hempseed and cardiovascular health: nutritional composition, mechanisms and comparison with other seeds
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1669375/full
For acne, a review of the efficacy of CBD & hemp extracts (nice charts)
Sustainable Utilisation and Resilience of Industrial Hemp Supply Chains: A Systematic Review of Advancing Skin Health Through Anti-Inflammatory Nutraceuticals for Acne Treatment
https://www.preprints.org/frontend/manuscript/7fe32dffe14cf571056e4c0c0440cb64/download_pub
A review on the antiviral activities of hemp
Industrial Cannabis sativa (Hemp or fiber type): Antiviral Activities-An updated Review
https://www.researchgate.net/publication/398123812_Industrial_Cannabis_sativa_Hemp_or_fiber_type_Antiviral_Activities-An_updated_Review
On the negatives of cannabinoids in psychiatry, a book chapter on treating intoxication & cannabis-induced psychosis
Chapter 4. Cannabis and Cannabinoids
https://psychiatryonline.org/doi/abs/10.1176/appi.books.9798894550862.lg04
⚠️ Harms ⚠️
For coronary heart disease, public health data found those smoking & vaping cannabis had a significantly higher risk & in those with pre-existing risk factors, combined consumption methods, especially smoking & eating, exacerbated those risks
Exploring the Link: Marijuana Use Patterns and Their Impact on Coronary Heart Disease Risk
https://pubmed.ncbi.nlm.nih.gov/41347515/
For the smoking vs. vaping of cannabis, while vaping reduced toxicant exposure, both had similar changes to heart rate, blood pressure & altered lung immune responses
Health impacts of cannabis: focus on smoking vs. vaping effects on the respiratory and cardiovascular systems
https://journals.lww.com/co-pulmonarymedicine/abstract/9900/health_impacts_of_cannabis__focus_on_smoking_vs_.294.aspx
In US high schoolers, a review found cannabis use associated with a ~2x risk for suicidality
Association Between Marijuana Use and Suicidality in US High-Schoolers: A Scoping Review
https://digitalcommons.fiu.edu/cgi/viewcontent.cgi?article=1021&context=ajncd
“Meta-analyses reported that cannabis users had more than double the odds of a suicide attempt and a 1.5- to-2.0-fold increased odds of suicidal ideation compared to non-users. This association remained significant even after statistically controlling depression. Stronger associations were identified among females, adolescents engaging in polysubstance use, and those using cannabis at school.”
For suicide & self-harm in people with cannabis-related hospital contacts, Canadian public health data found a 5.4x increase in deliberate self-harm & a 9.2x increased risk of death by suicide within three years relative to the general population
Deliberate self-harm and suicide in individuals with cannabis-related hospital contacts in Ontario, Canada
https://www.nature.com/articles/s41380-025-03339-9
In people with first-episodic psychosis, those using high-potency cannabis had significantly elevated dissociative experiences
Self-Disturbance in First-Episode Psychosis: Theoretical Framework and Potential Cannabis Interactions - A Systematic Review
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1733254/abstract
For psychosis & cannabis, a German region found a stable number of cases before & after legalization, but a higher number of cannabis-induced psychosis.
The Frequency of Psychotic Disorders Since the Legalization of Cannabis in Germany A before-and-after analysis
https://di.aerzteblatt.de/int/archive/article?id=247221&src=search
In Danish medical cannabis users, a survey of their side effects clustered into four groups: cognitive dysfunction, dizziness, xerostomia (dry mouth) & feeling “high”
Patients’ perceived benefit and side effects from the use of medicinal cannabis – a cross-sectional survey study from Denmark
https://www.degruyterbrill.com/document/doi/10.1515/jcim-2025-0277/html
In people who use cannabis before hip or knee surgery, they had more emergency department visits, opioid use & loosening
Impact of Preoperative Cannabis Use on Short and Mid-Term Postoperative Outcomes Following Total Hip and Knee Arthroplasty
https://www.sciencedirect.com/science/article/pii/S0972978X25004805
In people who had shoulder surgery, the cannabis users had a higher risk for COPD exacerbation, acute kidney failure, pneumonia, prosthesis loosening, opioid dependence & inflammation
Cannabis Use as a Negative Predictor of Complications Following Total Shoulder Arthroplasty
https://www.sciencedirect.com/science/article/abs/pii/S1045452725001208
In people with type 2 diabetes, there was a greater risk of eye problems among those with cannabis, opioid, or cocaine use disorder
The impact of opioid, cannabis and cocaine use disorder on the risk of diabetic retinopathy in patients with type 2 diabetes mellitus
https://pubmed.ncbi.nlm.nih.gov/41331286/
In the hair biology of cannabis users, higher cannabis exposure was associated with increased hair loss scores & reduced follicular density
Modeling Oxidative Stress–Linked Telogen Effluvium: A Monte Carlo Simulation Using Published Trichoscopy Norms and Cannabis Exposure Distributions
https://www.biorxiv.org/content/biorxiv/early/2025/12/03/2025.12.01.691705.full.pdf
In a small study of people with cannabinoid hyperemesis syndrome, genome-wide RNA sequencing found those with CHS had more activation of their adaptive immune system
Transcriptomic Evidence of Acquired Cannabis Hypersensitivity in Cannabinoid Hyperemesis Syndrome
https://www.researchsquare.com/article/rs-8116530/v1
These included “upregulation of B-cell related immunoglobin transcripts and altered expression of T cell, monocyte, and neutrophil-related transcripts. DEGs [differentially expressed genes] also suggested increased matrix degradation, and reduced adhesion and protease inhibitor transcripts, consistent with impaired gut barrier function. Digital HLA isotyping revealed increased MHC Class I expression, Class II allele restriction, and down-regulation of IgE receptor transcripts, a known response to elevated IgE levels in allergic hypersensitivity.”
For cannabinoid hyperemesis syndrome, a study for tracking their significant burden of pain severity & anxiety
Pilot Study Measuring Patient Reported Outcomes in Cannabinoid Hyperemesis Syndrome (CHS) patients treated in the Emergency Department
https://pubmed.ncbi.nlm.nih.gov/41327982/
For cannabinoid hyperemesis syndrome, Massachusetts public health data found the highest rise in prevalence among young adults plus Hispanic & Black people
Increasing Prevalence of Cannabinoid Hyperemesis Syndrome in Young Adults and Minority Populations
https://journals.lww.com/ajg/abstract/2025/12000/increasing_prevalence_of_cannabinoid_hyperemesis.35.aspx
For bullous lung diseases (a type of chronic obstructive pulmonary disease), a series of 3 cases associated with cannabis smoking
CANNABIS SMOKING AND BULLOUS LUNG DISEASE (BLD): A CASE SERIES
https://journal.chestnet.org/article/S0012-3692(25)04832-9/fulltext
A case report of an adolescent with cannabis-induced psychosis
Marijuana Induced Psychosis: A Pediatric Case Report
https://www.sciencedirect.com/science/article/pii/S1555415525003216
A case report of psychosis after stopping cannabis
New Onset Psychosis Following Cannabis Discontinuation: A Case Report
https://www.sciencedirect.com/science/article/pii/S2773021225000586
A case report of a sudden cardiac death in a young man linked to cannabis use
A Fatal Case of Coronary Thrombosis in a Young Male Triggered by Marijuana Use
https://assets.cureus.com/uploads/case_report/pdf/347384/20251129-191147-kf8hr.pdf
A case report of hypersensitive pneumonitis (lung inflammation when exposed to an antigen) in a person using methamphetamine & cannabis
RECURRENT HYPERSENSITIVE PNEUMONITIS DUE TO METHAMPHETAMINE AND CANNABIS USE
https://journal.chestnet.org/article/S0012-3692(25)02960-5/fulltext
In rats with prenatal CBD exposure, they were smaller & weighed less, but the only behavioral change was to their homing behavior
Neurodevelopmental outcomes following prenatal cannabidiol exposure in male and female Sprague Dawley rat offspring
https://www.sciencedirect.com/science/article/pii/S0306452225011650
In a rat model of THC & alcohol co-use, this thesis project found increased alcohol seeking & significant deficits to recognition memory & fear extinction learning (of relevance to PTSD) via changes to brain levels of a glutamate receptor (the brain’s primary excitatory neurotransmitter)
Behavioral and Neural Alterations Induced by Concurrent THC and Alcohol Use: Preclinical Insights into Comorbid Effects and Therapeutic Implications of mGlu5 Modulation
https://dc.etsu.edu/etd/4636/
In neuroblastoma cells, THC caused neurotoxicity via oxidative stress & dysfunction of the mitochondria (powerhouse of the cell)
Evaluation of THC-induced neurotoxicity via oxidative stress in undifferentiated SH-SY5Y cells
https://www.sciencedirect.com/science/article/pii/S1382668925002662
🐁 Preclinical 🐁
In a monkey & tissue model of HIV infection, CBD caused antiviral effects, suggesting it as an adjunctive with antiretroviral therapy
Antiviral and Anti-inflammatory Effects of Cannabidiol in HIV/SIV Infection
https://pubmed.ncbi.nlm.nih.gov/41040324/
In a mouse model of Alzheimer’s disease, inhaled CBD reduced neuroinflammatory markers including TNF-α, IL-1β & IFN-γ via AKT1, TRPV1, & GPR55
Rethinking Alzheimer’s: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control
https://www.eneuro.org/content/12/10/ENEURO.0114-25.2025
In a mouse model of chronic kidney disease, oleoylethanolamide (the endocannabinoid of satiation (my video here)) lowered kidney inflammation, scarring & damage while improving function
Uncovering the pleiotropic effects of oleoylethanolamide on obesity-driven chronic kidney disease in mice
https://www.sciencedirect.com/science/article/pii/S0014299925011902
In a rat model of chronic THC injections, they experienced tolerance to the effects, but no withdrawal symptoms when it was stopped
Tolerance but No Spontaneous Withdrawal Following Repeated THC Injections in Male and Female Rats
https://www.liebertpub.com/doi/abs/10.1177/25785125251404395
In developing chick embryos, CBD caused strong antioxidant activity in the liver & brain, moderate antioxidant activity in the striated & smooth muscles & oxidative stress in the heart tissue
Dose- and tissue-dependent effects of cannabidiol on antioxidant status in developing chicken embryos
https://www.nature.com/articles/s41598-025-31097-9_reference.pdf
In human placenta tissue, CBD reduced the inflammatory response via the NF-κB pathway
Cannabidiol reduces LPS-induced inflammatory response in the human placenta by reducing NF-κB translocation
https://link.springer.com/article/10.1186/s42238-025-00369-6
In a dendritic cell model of Alzheimer’s disease, PEA caused significant immunomodulatory effects & promoted their maturation
The immunomodulating effect of palmitoylethanolamide on human myeloid dendritic cells and its possible impact on Alzheimer’s disease
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1664164/abstract
Against salmonella, a thesis project on the antibacterial properties of CBD
Antibacterial Properties of Cannabidiol and Phage Tailspike Proteins Against Salmonella Strains
https://www.proquest.com/openview/a9ba42e499c3c9a00cb0c61a7a9f7088/1
🆕 Novel Studies 🆕
(my grab bag section for stuff I haven’t quite seen before)
For cannamom culture, an analysis of blogs & Instagram posts on the themes of normalization, destigmatization, responsible use & motherhood ideals “including thinness, productivity, mental wellness, and engaged parenting”
Mothers Marketing to Mothers: An Exploration of Cannabis Use and Constructions of Motherhood on Instagram and Blog Posts
https://journals.sagepub.com/doi/pdf/10.1177/29768357251403255
Most of this also applies to cannapapa culture. The kids know that, after a trip to the basement, I’m more calm & I read the books more dramatically.
(for you neuro-nerds)
In sensory neurons, the minor cannabinoids caused a variety of effects
Minor Cannabinoids CBD, CBG, CBN and CBC differentially modulate sensory neuron activation
https://pubmed.ncbi.nlm.nih.gov/41256665/
“Individually, CBD, CBG and CBC directed greater response magnitudes when compared to CBN. All four minor cannabinoids activated overlapping but distinct size populations of sensory neurons. CBD and CBG activated the widest range of DRG [dorsal root ganglions are neuron clusters in the spinal nerve that intake sensory stimuli such as pain, touch & temperature] neuron sizes (smaller-larger) overlapping with smaller capsaicin-sensitive neurons. In contrast, CBN and CBC activated predominantly larger sensory neurons. CBD diverged from other minor cannabinoids in directing a linear dose-response profile whereas CBG and CBC directed sigmoidal dose-response profiles and CBN activated DRG neurons with an inverted U-shaped dose-response relationship. CBD-induced activation of DRG neurons was dependent on co-expression of the nociceptive channel TRPV1 plus cannabinoid receptor 1 (CB1R), whereas CBN-induced activation was independent of TRPV1.”
For cannabis smoke, a thesis project analyzed the chemical components & time scales
Chemical Characterization and Evolution of Cannabis Smoke in Indoor Environments
https://utoronto.scholaris.ca/server/api/core/bitstreams/1940f663-3f1f-4411-a933-7b3b6087c768/content
📰 US Headlines & Fav Articles 📰
I don’t usually bother with rumors, but it looks like cannabis may be getting rescheduled in the US from Schedule I (like heroin) to Schedule III (like ketamine)
https://www.marijuanamoment.net/trump-may-be-about-to-announce-hes-reclassifying-marijuana-opponents-warn-as-white-house-denies-rumors/
However, as we often point out around here, this changes little except taxes & bankruptcies. It won’t matter much in criminal cases because for trafficking, the penalties are mandatory minimums already present in the Controlled Substances Act & for possession, those charges are usually brought at the state & local level, rarely the federal level. Rescheduling also will not affect prior convictions or cause expungements of records. All of the federal restrictions on benefits, employment & gun ownership will be unchanged. It will matter little for access to banking services (according to the Congressional Research Service). It won’t really alter cannabis research, though it will be easier to register your studies through the DEA. All of the state medical & adult-use cannabis programs will remain federally illegal, just that they will be Schedule III illegal instead of Schedule I illegal. And most importantly, for the patients, accepted medical use for cannabis will only be through the long & rigorous FDA approval & prescription process, and that agency is not keen on botanical products like cannabis flower because they are hard to standardize.
The main benefit is finally ending the terrible drag of the 280E tax burden where canna-businesses couldn’t make regular deductions because their product was in Schedule I or II, but even that will be complex (according to CohnReznick LLP). Look at ketamine. It’s Schedule III & you still get in trouble for using it without a prescription & it’s still hard for a business to work with it.
While rescheduling will be a boon for businesses, overall, this should have been done by Jimmy Carter in the Swinging ‘70s & not Donald Trump in the Roarin’ ‘20s.
In Massachusetts, the first rules for cannabis social clubs have been approved in New England
https://www.marijuanamoment.net/massachusetts-officials-approve-rules-allowing-marijuana-social-consumption-lounges-to-open/
The importance of this right to gather goes back to Dennis Peron & the AIDS activists who said that we should have the right to grow it, sell it & consume it together. See my graphic novel about this time in canna-history.
In Minnesota, cannabis is legal, but thousands of people are being prosecuted for having cannabis in their car because it’s not in the trunk or sealed in the original packaging
https://www.marijuanamoment.net/minnesota-legalized-marijuana-but-thousands-of-people-are-still-being-prosecuted-for-carrying-cannabis-in-their-cars/
Also, what do you do if you have a motorcycle? Boof it?
In Louisville, a man on parole was forced by his parole officer to quit a job at Cornbread Hemp because of potential THC exposure
https://spectrumnews1.com/ky/louisville/news/2025/12/05/parolee-forced-to-quit-his-job-after-months-on-the-job
Relatedly, the story behind this brand was that co-founder James Higdon was in the original ‘Cornbread Mafia’, an infamous group of Kentucky weed bootleggers in the ‘80s with a swaggering book on the subject.
So while this headline sounds pretty bad, if I was a parole officer who had a parolee working under a famous & unrepentant local criminal, I too might pause.
In Indonesia, the American basketball player Jarred Shaw caught with cannabis gummies avoided the death penalty & instead got 26 months in prison
https://hightimes.com/news/world/jarred-shaw-indonesia-thc-gummies-sentence/
History Corner: In the paper of Northern China during the late 14th century, it was made from paper mulberry & hemp fibers treated with egg white
Paper production and usage in the late fourteenth century in northern China: insight from paper fragments unearthed at the Dove Cave site
https://link.springer.com/article/10.1007/s12520-025-02311-6
Fun Fakt: the oldest surviving piece of paper is from China, 2,000 years ago. “This paper and similar bits of paper surviving from the next century are thick, coarse and uneven in their texture. They are all made of pounded and disintegrated hemp fibers. From the drying marks on them, it is evident that they were dried primitively on mats woven as pieces of fabric [also likely hemp].”
!!!! SPOILER ALERT FOR MOBY DICK !!!!
I am deadly serious. Listening to the Shakespearean actor Frank Muller reading Moby Dick was one of the peak experiences of my life (literary & otherwise). And if you don’t know how the story finishes, steal my copy of the audiobook here & let Melville & Muller drag you on towards the inevitable end. It’s an intoxicating experience.
That being said……….. and you want to proceed anyway………..
In this essay on Moby Dick through the lens of the UN’s Sustainable Development goal #14 ‘Life Below Water’, the authors remind us that what stopped Captain Ahab & ended his mad quest was… hemp
Captain Ahab’s downfall, as a Violator of SDG 14, Reveals Moby Dick as an Embodiment of Nature’s Vengeance and a Foreshadowing of Humanity’s Potential Fate
https://repository.rmutr.ac.th/bitstream/handle/123456789/1679/rmutrcon2025_33.pdf
Remember, that if you view the book through the lens of CLR James in ‘Mariners, Renegades, and Castaways’, Captain Ahab is a symbol of Amerikan imperialism. Funded by pious yet mercantile Quakers, men of color led by white officers are sent out on long, dangerous missions to kill whales in a bloody maelstrom & melt them down into a luxurious oil for lighting the homes of the rich while sailing in a ship named after a decimated Native American tribe. And Ahab wants to destroy the one creature that dared to strike back at him, the White Whale that took his leg. But in the end, it was the hemp rope of our beloved cannabis that the whale finally used to (perhaps) pull Ahab down to his destruction.
🌐 International Updates 🌐
RIP Peter Homberg, the great cannabis lawyer of Germany
https://cannareporter.eu/en/2025/12/06/morreu-peter-homberg-reconhecido-advogado-alemao-especializado-em-canabis-medicinal/
https://read.letterhead.email/cannabis-law-report/123671
I only met Peter on a few occasions, but it always impressed me that even when he was dealing with a low-level figure like me, he was always the height of grace & affability. I always saw him at the conferences sharing his wisdom from the stage & you could see his work online of legitimizing cannabis to the German public, leading to Germany now being one of the forefront cannabis countries in the world.
Thank you Peter for your Work. You will be missed.
For the fractures of the 2024 UN narcotics meeting, a network analysis of the statements made
How and why consensus fractured at the 2024 session of the UN Commission on narcotic drugs: an exploratory study of international drug policy constellations using social network analysis and qualitative comparative analysis
https://www.tandfonline.com/doi/pdf/10.1080/09687637.2025.2590649
In Portugal, the grey market for hemp cigarettes & CBD flowers (sold as “collectibles”) has now been shut down & all CBD & THC must be sold under the country’s medicinal cannabis regime
https://hemptoday.net/portugal-reinforces-cannabis-controls-with-zero-tolerance-on-cbd-thc-in-tobacco-goods/
In Brazil, Meta suspended 50 big cannabis accounts & the government told them to knock it off
https://cannabislaw.report/brazil-meta-suspends-instagram-cannabis-profiles-minister-of-agrarian-development-and-family-agriculture-sends-please-explain-re-instate/
In Brazil, a study of the public perception of their drug laws
ESTUDO SOBRE A PERCEPÇÃO DA POPULAÇÃO EM RELAÇÃO À LEI DE DROGAS BRASILEIRA (Study of the Population’s Perception of the Brazilian Drug Law)
https://www.researchgate.net/publication/334038270_ESTUDO_SOBRE_A_PERCEPCAO_DA_POPULACAO_EM_RELACAO_A_LEI_DE_DROGAS_BRASILEIRA_Study_of_the_Population’s_Perception_of_the_Brazilian_Drug_Law
🚓 The War on Drugs 🚓
‘Trump’s Boat Strikes Could Make the Cartel Problem Worse’, with a haunting last quote
https://www.theatlantic.com/national-security/2025/12/war-drugs-venezuela-trafficking-trump/685094/
“Dan Foote, a former senior official in the State Department’s counter-narcotics bureau, told us. ‘They build spoilage into their business plans.’”
And by spoilage, he means 80+ men dead.
For survivors of the narco-boat strikes, the Pentagon is scrambling to figure out what to do with them because the legal trouble will balloon if they touch US soil
https://www.nytimes.com/2025/12/09/us/politics/pentagon-boat-strike-survivors.html
“If the U.S. military brings the survivors to the Navy-run prison at Guantánamo Bay, Cuba, lawyers defending them could file a habeas corpus lawsuit in U.S. federal court questioning whether there really is an armed conflict, for legal purposes, between the United States and cartels. Congress has not authorized the United States to engage in any such conflict.”
A legal analysis on the illegality of the narcotic boat strikes
Operation Southern Spear: Why the Crews, Drugs, and Boats are Not Targetable
https://www.justsecurity.org/126553/operation-southern-spear-international-law/
On the CIA & Palantir using tech to track Mexican cartels
https://www.intelligenceonline.com/americas/2025/06/16/cia-palantir-how-the-us-is-using-technology-to-track-mexican-cartels,110465597-eve
At the US-Mexico border, on the risk for migrants from organized crime violence (with a helluva strong quote in the title)
When elephants fight, it’s the grass that suffers: organized crime violence and risks for migrants at the U.S.–Mexico border
https://academic.oup.com/sf/advance-article/doi/10.1093/sf/soaf202/8365278
The DEA wants to put the synthetic cannabinoid CUMYL-PEGACLONE into Schedule 1
https://www.federalregister.gov/documents/2025/12/11/2025-22495/schedules-of-controlled-substances-placement-of-cumyl-pegaclone-in-schedule-i
Not exactly sure why this one got to the top of the list. A German study of synthetic cannabinoid harms referred to it as “the relatively ‘insignificant’ harmful effects of Cumyl-PEGACLONE”. And then they refer to a paper with this title: ‘Cumyl-PEGACLONE: A comparatively safe new synthetic cannabinoid receptor agonist entering the NPS market?’. Though there is this Australian case series with 3 of the fatalities where “the presence of Cumyl-PEGACLONE was considered to be highly significant”. But overall, I didn’t see anything about it being widely used in the US.
🚗 Driving 🚗
In New Zealand, new roadside drug testing will include a saliva screening for THC & other drugs, despite the fact that saliva THC levels are not linked to impairment levels
https://hempgazette.com/news/cannabis-nz-roadside-testing-hg2612/
On the effects of cannabis on cognition & driving skills, a review found significant discrepancies between performance outcomes & self-reports
Characterizing subjective and objective effects following cannabis use on cognition and driving: a systematic review
https://www.tandfonline.com/doi/abs/10.1080/09687637.2025.2595253
⚖️ Business, Laws & Education ⚖️
For retail rents, opening a dispensary caused them to decrease significantly
Do Dispensary Openings Impact Rents for Neighboring Retail?
https://www.tandfonline.com/doi/full/10.1080/08965803.2025.2464458
On how hemp cigarettes evade the FDA regulations that apply to tobacco products
TAAT hemp cigarettes’ unsubstantiated cessation and harm reduction claims
https://tobaccocontrol.bmj.com/content/early/2025/12/03/tc-2025-059573.abstract
For litigation on the health harms of high-THC products, an essay on the potential claims of plaintiff-side litigators & state attorney generals
Nipping it in the Bud: The Promise and Perils of Tort Litigation in Addressing the Health Harms of High-THC Products
https://scholarship.law.umn.edu/cgi/viewcontent.cgi?article=1038&context=mlr-headnotes
For cannabis legalization, a thesis project with a county-level analysis of citizen support & the sociopolitical factors
Bud on the Ballot: A County-Level Analysis of Citizen Support for Cannabis Legalization
https://dc.etsu.edu/cgi/viewcontent.cgi?article=6170&context=etd
For why certain US states adopt more liberal cannabis policies, this model found that a significant factor is “policy liberalism”
Utilizing Probit Analysis to Explain Marijuana Policy Adoption Across the Fifty States
https://ijessnet.com/wp-content/uploads/2025/11/1.pdf
In North Carolina, a comparative economic analysis of hemp for flower, fiber & grain
Economic feasibility and risk analysis of industrial hemp production: a comparative assessment of floral, fiber, and grain enterprises in North Carolina, USA
https://link.springer.com/article/10.1186/s42238-025-00364-x
On creating an elective undergrad course on medical cannabis
Therapeutic Uses of Cannabis: An Experience with an Elective Course to Introduce the Content in Undergraduate Medical Education
https://www.scielo.br/j/rbem/a/DGrsPkFdkTLfKYXkQrvMHmP/
🛡️ Harm Reduction News 🛡️
For the US opioid settlement funds, how they were distributed across 6 states for overdose prevention efforts
A descriptive study of drug overdose epidemics, overdose prevention efforts, and opioid settlement fund distribution across six states
https://www.sciencedirect.com/science/article/abs/pii/S0955395925003962
Harm Reduction Research
In British Columbia after drug decriminalization, interviews with harm reduction workers found little impact & “despite expectations of increased client engagement, sites received no additional funding and faced ongoing staffing and resource shortages”, with the toxic drug supply & rising homelessness having a greater impact than the policy itself
Exploring the early impacts of drug decriminalization on harm reduction and opioid agonist treatment service operations and delivery in British Columbia: insights from key informant interviews
https://link.springer.com/article/10.1186/s12889-025-25479-x
On Dublin’s first analysis of discarded needles near its supervised injection facility, they found a large reduction in discarded needles & drug-related litter within 500 meters of the facility
Dublin’s supervised injecting facility: An assessment of its impact on discarded needles
https://www.sciencedirect.com/science/article/pii/S0955395925003974
For public health drug early warning systems, on the benefits of collecting reports from drug-using communities
Incorporating experiential reports provided by people who use drugs into drug-related early warning systems: benefits, risks principles and approaches
https://www.sciencedirect.com/science/article/pii/S0955395925003949
In people who inject drugs, interviews about adverse police experiences
“Once You’re Labeled a Drug User, You Might as Well Stay the F** Home”: Adverse Police Experiences Among People Who Inject Drugs
https://www.tandfonline.com/doi/abs/10.1080/10826084.2025.2588639
For harm reduction, this thesis project looked at three case studies of accessible washrooms in Toronto’s gay village, a supervised consumption site in Ontario& a packed library school classroom
Harm Reduction as The Commons of Care: Three Case Studies in Toronto
https://utoronto.scholaris.ca/server/api/core/bitstreams/77ab2f0b-8be5-4d40-8052-5175c1f6d694/content
In outpatient drug treatment programs, interviews on the barriers to integrating medications for opioid use disorder
“They should be like penicillin”: barriers to the integration of medications for opioid use disorder in specialty treatment programs
https://link.springer.com/article/10.1186/s13722-025-00633-3
For harm reduction vending machines, on evaluating different access models
Breaking barriers: evaluating access models for harm reduction vending machines
https://www.sciencedirect.com/science/article/pii/S0955395925003755
For syringe service programs, interviews on how to integrate safer smoking supplies
Integration of safer smoking equipment in U.S. syringe services programs: Qualitative insights from program staff
https://www.sciencedirect.com/science/article/pii/S0955395925004025
For drug checking services, a thesis project reviewed 90 studies & found beneficial health behaviors
Investigating the Influence of Drug Checking Services on People Who Use Drugs
https://utoronto.scholaris.ca/server/api/core/bitstreams/6a42a2db-48d3-4d28-8465-62b06de41527/content
For naloxone in prisons, a review of its feasibility & efficacy for preventing opioid overdoses during & after incarceration
Effectiveness, acceptability, and feasibility of naloxone in carceral settings: a scoping review
https://link.springer.com/article/10.1186/s12954-025-01358-x
🍄 Plant Medicines, Psychedelics & Other Psychoactives 🍄
For coca leaf, the World Health Organization went against the science & refused to ease the coca leaf ban
https://www.marijuanamoment.net/world-health-organization-wont-ease-coca-leaf-ban-even-as-review-found-prohibition-is-more-dangerous-than-the-plant/
https://filtermag.org/world-health-organization-coca-prohibition/
The Psychoactive Internet’s love affair of the week is this article about a psychedelic mushroom of Papua New Guinea, unknown to Western science, that causes the appearance of little fairy-type people
https://nhmu.utah.edu/articles/experts-explore-new-mushroom-which-causes-fairytale-hallucinations
The Psychoactive Research
For how drumming induces altered states of consciousness, a review of the neurobiology
The neurobiology of altered states of consciousness induced by drumming and other rhythmic sound patterns
https://pubmed.ncbi.nlm.nih.gov/40668575/
Or just listen to Mickey Hart’s ‘Planet Drum’. Or read the book.
For athletes, on the benefits & risks of psilocybin & ketamine
Ketamine and psilocybin for athletes: A therapeutic breakthrough or a slippery slope?
https://www.sciencedirect.com/science/article/pii/S2211266925000696
Ayahuasca
For ayahuasca in brain scans, on the subjective experiences & EEG changes
Predicting and exploring ayahuasca effects: Perception, mind-wandering, and EEG oscillations
https://journals.sagepub.com/doi/abs/10.1177/02698811251389563
Oh man. Who doesn’t dream of drinking the Grandmother & hopping into a brain-scanning machine?
On the prohibition of ayahuasca in France, a book chapter on the legal history & links to cult & brainwashing
On Drugs and Cults: The Ayahuasca Ban in France
https://link.springer.com/chapter/10.1007/978-3-032-04368-9_6
For ayahuasca’s effect on pain & inflammation, a review of preclinical studies
Ayahuasca, Pain, and Inflammation: A Systematic Review of Preclinical Studies
https://www.mdpi.com/2813-1851/4/3/24
Other Psychedelics
On psychedelics in the EU, on their potential pathway to the implementation
Psychedelics: The pathway to implementation in the European healthcare systems
https://www.sciencedirect.com/science/article/pii/S0924977X25007862
Oddly, this study of psychedelics & prostate cancer in older adults found a link between them
Association between lifetime co-use of classic psychedelics and cannabis and prostate cancer diagnosis among US adults 50 years and older
https://www.nature.com/articles/s41598-025-30172-5
In people with existential distress after psychedelic experiences, interviews on their difficulties & the grounding practices that helped
Navigating Groundlessness: An interview study on dealing with ontological shock and existential distress following psychedelic experiences
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4817368
And for persistent altered states after psychedelics, a review of the literature on anxiety & feelings of unreality, persistent changes in perception & existential distress
Persistent Altered States: Psychological Treatment of Psychedelic Adverse Effects
https://www.psykologtidsskriftet.no/artikkel/2025as12ae-Persistent-Altered-States-Psychological-Treatment-of-Psychedelic-Adverse-Effects
And in people with hallucinogen persisting perception disorder (HPPD), a book chapter on their phenomenology & therapeutic management
Flashbacks, Hallucinogen Persisting Perception Disorder (HPPD), and Reactivations Following the Use of Classic Psychedelics: Classification and Therapeutic Management
https://pubmed.ncbi.nlm.nih.gov/41348264/
And 3 cases of psychedelic use linked to depersonalization/derealization disorders
Three Cases of Depersonalization/Derealization Disorder Related to the Use of Classic Psychedelics
https://econtent.hogrefe.com/doi/full/10.1024/0939-5911/a000959
Depersonalization sounds so dreadfully scary. I’ve read a good number of reports now & the idea that you don’t even know if you are real or anything around yourself is real or what is happening is terrifying. It’s like constantly being stuck on the edge of a K-hole. And you never know if & when it might finally alleviate.
For creativity & microdosing psilocybin, these 3 studies found a subtle boost in the divergent quality of ideas
Microdosing psilocybin and its effect on creativity: Lessons learned from three double-blind placebo controlled longitudinal trials
https://www.sciencedirect.com/science/article/abs/pii/S002839082500440X
For frontline healthcare workers with COVID-19-related depression & burnout, psilocybin plus Mindfulness-Based Stress Reduction caused clinically significant improvements in depressive symptoms.
Psilocybin-assisted group psychotherapy and mindfulness-based stress reduction for frontline healthcare provider COVID-19-related depression and burnout: A randomized controlled trial
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004519
In humans taking one dose of psilocybin, those with more mystical experiences & more lasting psychological benefits had greater increases in synaptic density
Psilocybin’s effect on human brain synaptic plasticity
https://www.researchsquare.com/article/rs-7469144/v1
In two trials of psilocybin microdosing, there were no effects on attention, mood, cognitive control or well-being
Cognitive and subjective effects of psilocybin microdosing: Results from two double-blind placebo-controlled longitudinal trials
https://www.sciencedirect.com/science/article/abs/pii/S0028390825004307
In people with cancer using psilocybin, interviews on the importance of their set & setting
Set and setting in psilocybin-assisted therapy: A qualitative study of patients with cancer and depression
https://www.sciencedirect.com/science/article/abs/pii/S0163834325002014
In a person with advanced cancer, on the benefits of home-based psilocybin therapy
Home-based psilocybin-assisted therapy for a patient with advanced cancer: A case report
https://www.cambridge.org/core/journals/palliative-and-supportive-care/article/homebased-psilocybinassisted-therapy-for-a-patient-with-advanced-cancer-a-case-report/0770D8CAF507915293E754F934EC55A4
On psychedelics for substance use disorders, a meta-analysis of 105 studies
Psychedelics for the Treatment of Substance Use Disorders: An Overview of Systematic Reviews and Meta-Analyses
https://econtent.hogrefe.com/doi/abs/10.1024/0939-5911/a000953
For mental disorders & psilocybin, a review on 13 studies on depressive disorders, anxiety disorders, trauma disorders, stress disorders, alcohol use disorder, obsessive compulsive disorder & anorexia
Qualitative Research on Psilocybin-Assisted Psychotherapy for the Treatment of Mental Disorders: A Scoping Review
https://www.liebertpub.com/doi/abs/10.1177/28314425251394012
For bipolar disorder & psilocybin, a review of efficacy & concerns
Psilocybin use in bipolar disorder: A comprehensive review
https://www.sciencedirect.com/science/article/pii/S0165032725019275
For psychedelics & obsessive-compulsive disorder, a review of the efficacy & potential mechanisms
Psychedelics for the Treatment of Obsessive-Compulsive Disorder: Efficacy and Proposed Mechanisms
https://pubmed.ncbi.nlm.nih.gov/39611453/
For psilocybin & obsessive-compulsive behaviors, a review of 4 clinical trials & 9 pre-clinical studies
Psilocybin’s effects on obsessive-compulsive behaviors: A systematic review of preclinical and clinical evidence
https://genomicpress.kglmeridian.com/view/journals/psychedelics/1/4/article-p15.xml
For adults with depression, a review of using psilocybin
Psilocybin-assisted psychotherapy in adults with depression – A literature review
https://www.sciencedirect.com/science/article/pii/S0278584625002623
In people with PTSD, interviews on the efficacy of psilocybin
Investigational psilocybin treatment for post-traumatic stress disorder: a qualitative study of participant experience, trauma engagement, and differences from standard treatment
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(25)00626-1/fulltext
For alcohol use disorder, a review of the psychedelic MEAI
The Potential Therapeutic Effects of MEAI in the Treatment of Alcohol Use Disorder
https://link.springer.com/article/10.1007/s40429-025-00700-4
The neurobiological mechanisms of the aesthetic experience under psychedelics
Neuroaesthetics of the psychedelic state
https://pubmed.ncbi.nlm.nih.gov/40721152/
In a mouse model of chronic pain, a single dose of psilocybin rapidly relieved pain & depressive-like behaviors
Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain
https://www.nature.com/articles/s41593-025-02068-0
In skin cells, psilocybin reduced skin aging
Psilocybin alleviates high-glucose and high-lipid-induced skin aging in BJ5Ta fibroblasts
https://cdnsciencepub.com/doi/full/10.1139/bcb-2025-0250
MDMA
On MDMA for PTSD, a review of trials found significant symptom reduction with efficacy up to 12 months
Evaluating the efficacy and safety of MDMA for the treatment of Post Traumatic Stress Disorder: a systematic review
https://aigne.ucc.ie/index.php/smj/article/view/4364
For MDMA in psychiatry, a review of its potential benefits in PTSD, autism, eating disorders with co-morbid PTSD & anxiety related to life-threatening illnesses
MDMA in Psychiatry: From PTSD to emerging indications, safety, and future directions
https://genomicpress.kglmeridian.com/view/journals/psychedelics/1/3/article-p18.xml
Ketamine
In children with sickle cell disease, ketamine was associated with decreased length of stay & days on intravenous opioids
Increasing ketamine administration in children’s hospitals for youth with sickle cell disease
https://ashpublications.org/bloodadvances/article/doi/10.1182/bloodadvances.2025016826/556935
In people with an eating disorder & treatment-resistant depression, ketamine use was associated with significant reductions in depression & eating disorder severity
Ketamine for treatment resistant depression in individuals with eating disorders: a comparison study
https://link.springer.com/article/10.1186/s40337-025-01448-y
A case report of acute confusion where IV ketamine caused a full return to consciousness within 45 minutes
Rapid Improvement in Consciousness After Low-Dose Ketamine in a Patient With Acute Confusion: A Case Report
https://assets.cureus.com/uploads/case_report/pdf/401499/20251207-393198-2imigj.pdf
A case report of ketamine linked to Torsades de pointes (a potentially fatal cardiac arrhythmia)
Ketamine with a Twist: The First Reported Case of Ketamine-Induced Torsades de Pointes
https://www.sciencedirect.com/science/article/pii/S2214027125003884
For ketamine & PTSD, a review of 7 studies found lower doses administered more often worked best
Effects of Intravenous Ketamine on Posttraumatic Stress Disorder (PTSD): A Systematic Review
https://pubmed.ncbi.nlm.nih.gov/41326978/
For pain management, a review of using nebulized (inhalable) ketamine
Breathing new life into pain management: a systematic review of nebulised ketamine for analgesia
https://link.springer.com/article/10.1186/s13049-025-01501-4
🍃 The Plant, its History & its Products 🍃
In a 17th-century Icelandic hemp fabric, on using strontium analysis to determine its age & that the hemp was perhaps grown in France or Scotland
First strontium isotope analysis of a heritage hemp fabric in Iceland
https://www.diva-portal.org/smash/record.jsf
🌱 Growing & Extracting 🌱
For hemp pesticide & solvent contamination, a review of the patchwork of international & US state regulations & guidance
Identification of Reference Values Intended to be Protective of Human Health for Potential Contaminants in Hemp Plant Material and Hemp-Based Products: Part II. Pesticides and Solvents
https://www.sciencedirect.com/science/article/pii/S2468202025000397
On the effects of irrigation & planting density on hemp production, irrigation was more important for yield & density was more important for quality
Evaluation of irrigation doses and planting density of hemp (Cannabis sativa, L.) in a temperate climate through CRITIC-TOPSIS-OWA
https://www.sciencedirect.com/science/article/pii/S2214317325000769
For cannabis polyploidy (extra copies of the chromosomes), on how to induce it & its enhancements to biomass, stem growth & cannabinoid content
Induction of polyploidy and its effect on cannabinoid content in Cannabis sativa L.
https://www.sciencedirect.com/science/article/pii/S0926669025019703
This is an agronomic technique used widely for many important agricultural products. The wheat used to make bread typically has 6 copies of its chromosomes. The only reason this technique wasn’t more widely applied to cannabis 50 years ago was because of Prohibition.
For the fungus southern blight on hemp, straw mulch significantly reduced prevalence & lowered the soil temperature, while black plastic mulch increased both of those factors, with early planting also reducing disease severity
Mulching and Time of Planting Impact on Southern Blight Disease and Industrial Hemp Production
https://www.preprints.org/frontend/manuscript/71971d64892d32205286dde543560106/download_pub
For acarine pests (mites), a review of protection methods for hemp
Sustainable Management Strategies for Acarine Pests of Industrial Hemp (Cannabis sativa subsp. sativa L.)
https://www.mdpi.com/2073-4395/15/12/2785
For the cannabis fungus Botrytis cinerea, on using bacteria from hemp seed oil against it
Characterization and antifungal properties against Botrytis cinerea of bacteria isolated from hemp seed oil
https://cdnsciencepub.com/doi/abs/10.1139/cjm-2025-0241
On the phytochemical profiling of Iranian cannabis with headspace solid-phase microextraction (HS-SPME), gas chromatography-mass spectrometry (GC-MS) & Fourier-transform infrared (FT-IR) analytical techniques
Comprehensive Phytochemical Profiling of Native Cannabis sativa L. from Dehloran Using HS-SPME GC–MS and FT-IR Techniques
https://pbp.medilam.ac.ir/article-1-377-en.html
A genetic study of cannabis based on the physical properties of the seeds
Genetic and phenotypic diversity in cannabis genotypes: insights from seed dimensions, mineral profiles, and Short Tandem Repeats (STR) markers
https://www.sciencedirect.com/science/article/pii/S2352407325000757
When extracting CBD & THC with supercritical carbon dioxide, this molecular dynamic analysis looked at the solute-solvent interaction & why ethanol improves yield
A molecular dynamics solvation study of CBD and -THC in sc
https://www.sciencedirect.com/science/article/abs/pii/S0167732225022731
⚙️ Analyzing & Formulating ⚙️
For CBD bioavailability, a review of oil-based vs oil-free emulsions
Oil-based and oil-free formulations for enhancing cannabidiol bioavailability
https://link.springer.com/article/10.1186/s42238-025-00371-y
On delivering CBD with nano magnesium aluminometasilicate
SYNTHESIS AND OPTIMIZATION OF MAGNESIUM ALUMINOMETASILICATE-TEMPLATED MESOPOROUS NANOPARTICLES FOR CANNABIDIOL DELIVERY: A NOVEL APPROACH
https://d1wqtxts1xzle7.cloudfront.net/125477283/55307-libre.pdf
🍞 Food, Nutrition & Hemp Seeds 🍞
On cannabis sprouts as a promising food source
Exploring the nutritional profile of Cannabis sativa L. sprouts: a promising food source for enhancing food security
https://www.sciencedirect.com/science/article/pii/S0023643825015282
In probiotic yogurt, on the effects of adding hemp seeds
Microbial quality and sensory evaluation of probiotic yogurt fortified with functional seeds
https://www.explorationpub.com/Journals/eff/Article/1010101
On making hemp seed cake flour through a combined delignification & enzymatic hydrolysis approach
Exploring deep eutectic solvents and enzyme-based hydrolysis for hemp seed flour valorization
https://www.sciencedirect.com/science/article/pii/S0023643825015415
In sheep, low doses of hemp seed powder had immune-enhancing effects
The effect of low doses of hemp seed powder (Cannabis sativa) on some immune characteristics in the blood serum of Awassi sheep
https://iopscience.iop.org/article/10.1088/1755-1315/1549/1/012073/pdf
In sheep, hemp seed power increased their levels of progesterone, iron, zinc, copper & molybdenum while dropping their concentrations of lead & arsenic, though increasing antimony
Progesterones Role in Regulating Heavy Metal Levels in Awassi Ewes Supplemented with Russian Cannabis Seed Powder
https://iopscience.iop.org/article/10.1088/1755-1315/1549/1/012057/pdf
🏗️ Industrial Uses & Fiber 🏗️
On 3D printing hemp-bioplastic composites
Advancements in 3D Printed Hemp-PLA Composites: A Sustainable Approach for Additive Manufacturing
https://www.sciencedirect.com/science/article/abs/pii/S3050475925010346
For cleaning the heavy metal cadmium from water, on using lignocellulose from hemp stalks
Biosorption of aqueous cadmium using chemically delignified lignocellulose from industrial hemp stalks: kinetics, isotherms, and thermodynamics
https://www.sciencedirect.com/science/article/pii/S2949736125001551
On creating superhydrophobic coatings with hemp stalk cellulose via UV curing
UV-curing fabrication of universal superhydrophobic coatings based on modified hemp stalk cellulose for multifunctional applications
https://www.sciencedirect.com/science/article/abs/pii/S0300944025008033
For wound dressing, on creating a woven fabric from cotton, hemp & pineapple yarns on a handloom
ANALYSING MECHANICAL PROPERTIES OF A TRI PLY TWISTED COTTON, HEMP, PINEAPPLE YARNS AND ITS SUSTAINABLE HANDLOOM FABRIC FOR MEDICAL APPLICATION
https://openurl.ebsco.com/EPDB%3Agcd%3A11%3A8947659/detailv2
A method for producing micronized cellulose powder from hemp fiber
Green disassembly: direct preparation of cellulose micronised powder from hemp by deep eutectic solvent
https://link.springer.com/article/10.1007/s10570-025-06887-z
On making epoxy composites for car panels from hemp, pineapple & glass fibers
Sustainable epoxy composites from hemp/pineapple/glass fibers for lightweight automobile panels
https://www.sciencedirect.com/science/article/abs/pii/S0141813025099490
A polymer composite of hemp & glass fiber reinforced with nanofillers
Investigating the Water Resistance and Structural Stability of Hemp‐Glass Fiber Polymer Composites Reinforced With Graphene and MXene Nanofillers
https://4spepublications.onlinelibrary.wiley.com/doi/abs/10.1002/pc.70703
On making composite panels from hemp shives & starch
Green innovation in materials: eco-panels made from hemp shives and starch
https://omorika.sfb.bg.ac.rs/handle/123456789/2446
On creating sustainable buildings with hemp-lime composites
Hemp-lime composites for sustainable and carbon-neutral buildings under changing climate
https://www.sciencedirect.com/science/chapter/edited-volume/abs/pii/B9780443156700000016
For hempcrete, on the influence of hemp size & proportion on strength & thermal performance
Insights into the influence of hemp size and proportion on the strength and thermal performance of hempcrete
https://www.tandfonline.com/doi/abs/10.1080/19648189.2025.2594590
On improving lime hemp concrete with bio-based polymer additives
How about improving the lime-hemp concrete properties using bio-based polymer additives?
https://www.sciencedirect.com/science/article/pii/S0958946525005049
🌿 THE CANNA-SCIENCE ARCHIVE 🌿
The Journal of Christian Nursing decided to focus on cannabis:
With “the physiology of the ECS using a biblical worldview”
The Endocannabinoid System Scientific Insight and Biblical Reflection
https://journals.lww.com/journalofchristiannursing/abstract/2026/01000/the_endocannabinoid_system__scientific_insight_and.11.aspx
And on applying wisdom & discernment to medical cannabis
Medical Cannabis Applying Wisdom and Discernment
https://journals.lww.com/journalofchristiannursing/citation/2026/01000/medical_cannabis__applying_wisdom_and_discernment.1.aspx
And navigating bias against it
Navigating Bias on Medical Cannabis
https://journals.lww.com/journalofchristiannursing/abstract/2026/01000/navigating_bias_on_medical_cannabis.9.aspx
And a history of human medical cannabis use
The History and Use of Medical Cannabis
https://journals.lww.com/journalofchristiannursing/abstract/2026/01000/the_history_and_use_of_medical_cannabis.10.aspx
There is a small but persistent belief that Jesus was using cannabis oil to heal the cases of epilepsy we see in the Bible. And we already know the Hebrews were burning cannabis on altars. So that, along with the guess that he went to India during his lost years, point to a Green Jesus.
A Moroccan review of the botanical diversity & therapeutic promise of cannabis
Cannabis sativa L.: An integrative review of its botanical diversity, phytochemistry, and therapeutic promise
https://www.ecoeet.com/-Cannabis-sativa-L-An-integrative-review-of-its-botanical-diversity-phytochemistry,214959,0,2.html
🏥 Public Health, Legalization Effects & Bioassays 🏥
For monitoring cannabis legalization & public health, a review of 110 papers on recommendations
Adult-use cannabis legalization in the united states: a scoping review of outcome monitoring recommendations
https://link.springer.com/article/10.1186/s12889-025-25720-7
In a geriatric primary care clinic, lessons on developing & implementing a medical cannabis clinic
Development and Implementation of a Medical Cannabis Clinic Within a Geriatrics Primary Care Clinic: Preliminary Data
https://agsjournals.onlinelibrary.wiley.com/doi/pdf/10.1111/jgs.70217
For German doctors before cannabis legalization, they anticipated increased cannabis consumption & disorders, but “despite 40.3% prescribing medical cannabis in their practice,… only few showed interest in additional training”
Attitudes and expectations of primary care physicians regarding recreational cannabis legalization in Germany: a pre-implementation survey
https://link.springer.com/article/10.1186/s42238-025-00367-8
On Australian medical cannabis websites, an analysis of “doubtful prescribing practices”
Doubtful medical cannabis prescribing practices identified from 55 medical cannabis websites
https://journals.sagepub.com/doi/abs/10.1177/00048674251396013
In South African pharmacists, a survey on their knowledge of CBD & cannabis
South African retail pharmacists’ knowledge of cannabidiol and cannabis, and training recommendations
https://openurl.ebsco.com/EPDB%3Agcd%3A15%3A37603679/detailv2
In Australia, wastewater analysis for the surveillance of cannabis usage
Cannabis consumption in Australia 2018-2025: Socio-economic and regional trends from wastewater and survey data
https://pubmed.ncbi.nlm.nih.gov/41347598/
For the wastewater monitoring of cocaine & cannabis, a review of methods & applications
Wastewater-Based Epidemiology for Monitoring Cocaine and Cannabis: A Review of Methods and Applications
https://www.sciencedirect.com/science/article/pii/S1573412925001124
I don’t quite get why epidemiologists love wastewater monitoring so much, but it is a rather robust field of research.
🧒 Adolescents & Young Adults 🧒
For adolescent cannabis use, a review suggested early use correlated with higher use of mental & physical health services & that teens who use early have more injuries, poisonings & respiratory problems, concluding that “five years of data show that the best advice on teen use of cannabis is: Don’t use. Next best: Delay use.”
Early Cannabis Use Poses Risks to Physical and Mental Health: Delayed Use/Non Use Encouraged
https://ecronicon.net/assets/ecne/pdf/ECNE-17-01286.pdf
Listen, that sounds about right to me. I’m hoping my kids don’t start until they’re at least done with high school.
That’s how it went for me, but mostly only because I wasn’t cool enough for anyone to offer it to me before then.
In Lahore University students, interviews found that they used cannabis “for temporary emotional relief, using it to escape psychological distress caused by academic burdens, emotional pain, and social expectations. However, while marijuana initially provides perceived relief, it also contributes to increased dependency and negative emotional states in the absence of use.”
Marijuana Use and Social Relationships among University Students: A Case Study of District Lahore
https://assajournal.com/index.php/36/article/view/1149
Yep, sure sounds like weed use to me.
In Iranian students using cannabis, interviews on the effects on their life
Qualitative study of the lived experience of male students who consume Marijuana
https://frooyesh.ir/browse.php?a_id=5799&slc_lang=en&sid=1&printcase=1&hbnr=1&hmb=1
“The findings indicate a greater psychological impact from marijuana use, which includes aggression, emotional regulation disorders, increased deep sleep, apathy, experiences related to new addictive substances, experiences of financial difficulties, and lifestyle changes.”
For tobacco & cannabis co-use in young adults, on using smartphone data to analyze times & locations
Detecting spatiotemporal clusters of tobacco and cannabis use and co-use to inform smartphone-based interventions
https://psycnet.apa.org/record/2026-99022-004
In young adults using cannabis or alcohol to sleep, something happened behind a paywall…
Cannabis and Alcohol Use to Initiate Sleep Among Young Adults
https://jamanetwork.com/journals/jamapediatrics/article-abstract/2840034
🧠 The Brain & Neurological Disorders 🧠
In a genetic study of people with Alzheimer’s disease, those with certain variants of the FAAH enzyme (which breaks down anandamide) had slower rates of cognitive & neuroanatomical decline
Fatty Acid Amide Hydrolase Single Nucleotide Polymorphism rs324420A/C Associations with Alzheimer’s Disease
https://pmc.ncbi.nlm.nih.gov/articles/PMC11710220/
For neurodegenerative diseases, a review on the effects of cannabinoids
Effects of cannabinoids on neurodegenerative diseases
https://discoveryjournals.org/medicalscience/current_issue/v29/n163/e187ms3717.pdf
In a mouse model of adolescent THC exposure, the cognitive impairments occurred via glutamate signaling of the astrocytes (the most predominant brain support cell) in a circuit between the hippocampus (memory center of the brain) & the nucleus accumbens (a reward center & regulator of feeding, stress & motivation)
An astrocytic ensemble at vHip-NAc synapses modulates cognitive impairments induced by chronic tetrahydrocannabinol exposure
https://www.nature.com/articles/s41467-025-67166-w_reference.pdf
💭 Mental Health, Addiction & Cannabis Use Disorder 💭
For mental illnesses, a commentary on the effects of cannabis liberalization on mental illness
Centering Individuals With Mental Illness as an At-Risk Group in the Era of Cannabis Legalization and Commercialization
https://www.sciencedirect.com/science/article/abs/pii/S0149291825003935
For cannabis & psychotic-like experiences, public health data found that prior associations may have been confounded by comorbid use of other substances
Cannabis use and psychotic-like experiences in the All of Us Research Program
https://www.medrxiv.org/content/medrxiv/early/2025/12/02/2025.12.01.25341322.full.pdf
In children with autism using medical cannabis, Israeli public health data on patient characteristics
Medical Cannabis Use in Autism: Insights from an Israeli HMO on Patient Characteristics and Alignment with National Guidelines
https://www.liebertpub.com/doi/abs/10.1177/10445463251404404
In Canadian psychiatrists, a survey of their views on cannabis found two-thirds comfortable discussing it, but only one-third comfortable authorizing it
ATTITUDES AND PRACTICE PATTERNS OF CANADIAN PHYSIATRISTS REGARDING MEDICAL CANNABIS
https://pubmed.ncbi.nlm.nih.gov/41356262/
During the COVID stay-at-home orders, people with depression & anxiety had lower odds of cannabis use
Depression and anxiety mediate the relationship between COVID-19 stay-at-home orders and tobacco and marijuana use
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0337996
In people in the Pennsylvania medical cannabis program, a longitudinal analysis of their anxiety
Assessing anxiety longitudinally among medical cannabis patients in Pennsylvania
https://www.tandfonline.com/doi/full/10.1080/00952990.2025.2588273
In Black men who do & do not have sex with men, on their use of cannabis & tobacco as well as their cannabis refusal self-efficacy
Tobacco and Cannabis Use and co-Use, and Cannabis Refusal Self-Efficacy Among Black Men: A Cross-Sectional Study Examining Differences Between Men Who Have Sex with Men (MSM) and Non-MSM
https://www.tandfonline.com/doi/abs/10.1080/10826084.2025.2592877
For substance use disorders, a review on the therapeutic potential of inhibiting the FAAH enzyme (which breaks down anandamide) & the MAGL enzyme (which breaks down 2-AG)
FAAH and MAGL inhibition: Evolving approaches to treating substance use disorders
https://www.sciencedirect.com/science/article/pii/S1878747925002922
🧬 Reproduction & Hormones 🧬
In pregnant people co-using cannabis & tobacco, a survey on their use intentions found that they tend to view tobacco & cannabis use as distinct behaviors
Prenatal tobacco-cannabis co-use: A mixed-methods, convergent parallel study
https://academic.oup.com/ntr/advance-article-abstract/doi/10.1093/ntr/ntaf251/8364977
In pregnant mice with sickle cell disease, cannabinoid exposure increased their offspring’s hypersensitivity to pain
Cannabinoid exposure in utero exacerbates hyperalgesia in offspring of sickle mice
https://www.sciencedirect.com/science/article/pii/S0006497125025844
🦴 Pain, Musculoskeletal, Inflammation & Surgeries 🦴
In people with sickle cell disease & chronic pain, dronabinol (pharmaceutical THC) caused improved social impact of the disease, but the pain & quality of life measures were better, but not statistically significant
Interim analysis of a placebo controlled study of dronabinol for adults with sickle cell disease and chronic pain
https://www.sciencedirect.com/science/article/pii/S0006497125039424
In people with facial fractures, those who tested positive for illicit drugs, including cannabis, had significantly higher odds of hospital burden outcomes, including more psychiatry services, ventilator management & critical care services
Impact of Illicit Drug Use on Facial Fracture Patterns and Hospital Resource Utilization
https://www.mdpi.com/1943-3883/18/4/51
I believe that anyone who ever watched the show Jackass would be unsurprised by these results.
In people with ankle fractures, cannabis users had no changes to their postoperative complications
Postoperative Outcomes After Ankle Fracture ORIF in Patients With Documented Nicotine and/or Cannabis Use: An Observational Analysis
https://journals.sagepub.com/doi/abs/10.1177/10711007251393661
For women with chronic pelvic pain, many reported current or past use of CBD for symptom relief
Cannabidiol (CBD): An acceptable non-hormonal treatment option for women suffering with chronic pelvic pain – a cross-sectional observational study
https://www.sciencedirect.com/science/article/abs/pii/S1876382025001398
In people with rheumatological conditions, on the development of a cannabis risk assessment tool
The development of a cannabis risk assessment tool for patients with rheumatologic conditions: a Delphi study
https://link.springer.com/article/10.1007/s10067-025-07807-z
On creating anti-inflammatory cannabinoid derivatives using bioreactor suspension cultures
Bioreactor-Based Suspension Cultures of Cannabis sativa for Enhanced Production of Anti-Inflammatory Cannabinoid Derivatives
https://pubs.acs.org/doi/abs/10.1021/acs.jafc.5c10683
❤️ The Heart & Blood ❤️
In people with thalassemia (a group of blood disorders), public health data found a strong association between cannabis use disorder & mental health disorders such as anxiety & depression
Association of anxiety and depression with cannabis usage disorder among thalassemia patients: A national inpatient sample analysis
https://www.sciencedirect.com/science/article/pii/S0006497125107118
🍽️ The Guts, Metabolism & the Microbiome 🍽️
In inflammatory bowel disease, the ECS seems to regulate gut neuronal death via inhibition of the s100β/RAGE/NF-κB complex
The endocannabinoid system likely regulates enteric neuronal death by inhibiting the activation of the s100β/RAGE/NF-κB complex during inflammatory bowel disease
https://www.sciencedirect.com/science/article/abs/pii/S0306987725002889
In broiler chickens injected with an antimicrobial peptide, some of the effects of lessened foot intake may be mediated via the CB1 receptor working with ghrelin (a hunger-stimulating hormone)
Effect of intracerebroventricular (ICV) injection of antimicrobial peptide expressed in the body-2 (LEAP-2) and its interaction with cannabinoid and ghrelin systems on food intake in broiler chickens
https://www.sciencedirect.com/science/article/pii/S0032579125014397
🖐️ The Skin & Topicals 🖐️
In a tissue model & human samples of pemphigus (rare skin disorders of blisters & sores), the CB2 receptor levels were high, suggesting them as a therapeutic target
[Cannabinoid receptor 2 inhibition on acantholysis in oral mucosal pemphigus]
https://pubmed.ncbi.nlm.nih.gov/41332407/
In a mouse model of psoriasis, the fatty-acid binding protein 5 (an endocannabinoid transporter) aggravated symptoms
Fatty acid-binding protein 5 aggravates psoriasis and psoriasis-like disease through ferroptosis
https://www.nature.com/articles/s41418-025-01630-4
🎗️ Cancer & Chemotherapy 🎗️
In exercising cancer patients, they had increased levels of anandamide, oleoylethanolamide & PEA
Endocannabinoid system and mood responses to acute aerobic exercise in adult cancer patients versus healthy controls: a pilot study
https://link.springer.com/article/10.1007/s00520-025-10221-5
In cancer survivors during COVID, their levels of cannabis use held steady
Cannabis Use Among Cancer Survivors Before and During the COVID-19 Pandemic, 2019-2021
https://d1wqtxts1xzle7.cloudfront.net/111605960/pkad031-libre.pdf
In uterine cancer tissue, CBD used immunomodulation to enhance tumor immune visibility while limiting expression of the immunotolerant HLA-G (a human leukocyte antigen)
CANNABIDIOL MODULATES CLASSICAL AND NON-CLASSICAL HLA EXPRESSION IN HUMAN CHORIOCARCINOMA CELL LINE
https://www.biorxiv.org/content/biorxiv/early/2025/12/02/2025.11.28.691248.full.pdf
In pancreatic duct cancer, the tumors had high levels of CB2 receptors, which could potentially be used for early diagnosis
Molecular Imaging of Pancreatic Duct Adenocarcinoma Using [18F]JR-1004, a Cannabinoid Type 2 Receptor Targeted Positron Emission Tomography (PET) Probe
https://link.springer.com/article/10.1007/s11307-025-02069-2
For treating cancer, on synthesizing rare varin cannabinoids
Aromatisation-based extract engineering of Cannabis sativa L. Unveils rare cannabinoids with anticancer potential
https://www.tandfonline.com/doi/full/10.1080/14786419.2025.2595528
💊 Synthetic Cannabinoids & Hemp-Derived Cannabinoids 💊
In semi-synthetic cannabinoid users, a survey of their demographics & of the cannabinoids used
Emerging Hemp-Derived Semi-Synthetic Cannabinoids, Absent Regulations: Patterns of Use and Adverse Effects Among a Sample of U.S. Cannabis Consumers
https://www.liebertpub.com/doi/abs/10.1177/25785125251391987
On detecting synthetic cannabinoids with platinum nanoparticles
Pt decorated Ti3C2Tx with facile electron transfer amplified electrochemical activity for ultrasensitive detecting synthetic cannabinoids
https://www.sciencedirect.com/science/article/abs/pii/S0026265X25038469
🔬 Biochemical Discoveries & Research Tools 🔬
On synthesizing the CBD cousin dihydrocannabidiol
Synthesis of dihydrocannabidiol catalyzed by FeCl3
https://openurl.ebsco.com/EPDB%3Agcd%3A11%3A21821723/detailv2
On using a mass spectrometer to differentiate between delta-8 & delta-9 THC isomers
Differentiating Δ8‐THC and Δ9‐THC Isomers: Mass Spectrometry Analysis and Computational Explanation
https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/rcm.70011
For estimating the boiling points of THC & THCV, on using thermogravimetric analysis & differential scanning calorimetry
Application of thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) to estimate the normal boiling points of ∆9-tetrahydrocannabivarin (THCV) and ∆9-tetrahydrocannabinol (THC)
https://link.springer.com/article/10.1186/s42238-025-00373-w
Thanks.
- lex
PS: For today’s album of female-led proto-rock, “Wild, Wild Women!” with Ruth Brown & LaVern Baker, a compilation album of two of the greatest stars of Atlantic Records in the 1950s. LaVern Baker was vaulted to stardom by the first track ‘Jim Dandy’ & a few other Top Ten R&B hits. Meanwhile, with Ruth Brown, they started called Atlantic Records “the house that Ruth built”. She was a hit maker through the whole decade & led to the label’s predominance in the R&B field. Both women later moved into TV & film (with Brown playing Motormouth Maybelle Stubbs in Hairspray), but then left the limelight for some decades before having resurgences near the end of their lives. Both were inducted into the Rock & Roll Hall of Fame as heroes of the early women of rock & R&B.
This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.