C&P#170: new sponsor ICBC! + sleep, cancer & epigenetics
Repugnant boat strikes + UAE liberalizes
CANNABINOIDS & THE PEOPLE
or; Drugs & Drug Wars
(buy my canna-graphic novels based on Moby Dick & proceeds go to Americans for Safe Access to support medical cannabis patients)
🌟 This week 🌟
Cannabinoids for cancer symptoms
4 sleep studies = mixed results
Genes & Greens: 3x on epigenetics & genetics
(3x) liver enzymes & cannabinoids
A lovely analysis of how CBD & THC alter genetic transcription across 105 tissue types
In France, the new synthetic cannabinoid is known as pète ton crâne’ [blow your skull]
First cannabis hexaploid!
Hello MDMB-5’Br-PINACA!
For mental health, meditation > psychedelics (first you take the helicopter, then you take the trail)
Vuelcos: the Omar Little of large-scale narco-trafficking
#EndDrugWars: the boat strikes are repugnant & Rubio is propping up the enemy
(this week’s numbers: ~9k words, ~23 minutes reading time, 183 papers)
Hello everyone,
Welcome to the 170th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news as well as coverage of other psychoactives, the War on Drugs & harm reduction. Support this work with a paid subscription or by buying me a coffee.
For producing cannabinoid content, work with my company White Whale Creations: writing, science archives, social media, newsletters & podcasts (especially podcasts).
As always, ask me anything!
📌 Editor’s notes 📌:
1. Glad to welcome ICBC as our first new sponsor of 2026. See below on why they’re close to my heart & how you can save 25%.
2. I reorganized the top of this newsletter for the new year & added a new subtitle to reflect its widened scope: Drugs & Drug Wars.
Also, inspired by the channel Bistro Huddy, I’m going to start donating all profits from my books sales to Americans for Safe Access. When the pigs are at the trough & the laws are badly written, ASA is there to stand up for the rights of the medical cannabis patients who often get lost in the roar of liberalization. You can donate directly here.
🤝 Sponsor 🤝: ICBC 2026!
I’m proud to be a new media partner of the International Cannabis Business Conference 2026. With 5,000+ people coming from 80+ countries, it’s one of the best reasons for your canna-business travel this year. And if you want to get the very best deal possible, the early bird tickets end on Jan 28th & on top of that, I can get you an extra 25% off with this coupon code: WhiteWhale25
Buy your tickets here:
https://internationalcbc.com/register/
Also, Alex Rogers who runs it is a cool guy. Just check out this rap video he did recapping cannabis in 2025. And that’s part of what makes this conference excellent. Alex makes it not just about the business during the day but always has great parties at night & places for people to connect with each other on a human level.
As someone who’s only been in Europe a couple of years now, I’ve found ICBC to be my best gateway into meeting both friends & business connections in the cannabis world. In fact, check out the homepage: that’s me & my (now) buddy Hirsh Jain just to the left of the B in business. I put my likeness where my mouth is.
This is a great conference. Come join me there.
🎥 Lex’s new work 🎤
@CannabinoidsAndThe People vids sponsored by CHRI & the National Cannabis Study:
My 2026 Canna-Hot Takes (one of them is good!)
Cannabis & Schizophrenia (the links)
Canna-Edu Vids for CV Sciences:
(on YT @CVSciencesInc & on TT @pluscbd)
My 📚 Vids:
(@LexPelgerAndHisBooks on TikTok, YouTube & Instagram)
Musical Documentaries & ‘One to One: John & Yoko’ (Taking recommendations!)
me and Pessoa love old Walt (Whitman)
‘Monkey King: Journey to the West’: an amazing book to read with your kids (thanks for the makeup to SoLu Styling)
And as always, at the bottom is the album of the week: from the grandfather of the Texas blues…
🧰 Free resources 🧰
CVResearch.info: the cannabinoid science archive I maintain for CV Sciences
My glossary of cannabinoid terms (& containing the legend for my Neural Ocean metaphor with endocannabinoid whales)
Roundup of fav newsletters:
#Canna: Marijuana Moment, Cannabis Law Report, Cultivated, Cannabis Musings (oy vey), Talking Joints Memo, Indigenous Cannabis Industry Association, Policy, Decoded, Dr. Peter Grinspoon, Doctor Approved, Medical Marijuana Memory Blog (by Dame Alice O’Leary Randall)
#DrugWar: InSight Crime, Marshall Project
#HarmReduction: Filter, National Harm Reduction Coalition, Canadian Drug Policy Coalition
#Psychoactives: Psychedelic Alpha, Ecstatic Integration, ICEERS, Substance
💖 Ways to support this work 💖
A paid subscription on Substack
Venmo: @Lex-Pelger
PayPal: donate here
📣 A request to spread the word 📣
This newsletter only spreads by word of mouth, so please forward to friends & colleagues.
🍃 BEST OF CANNABINOID SCIENCE 🍃
(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)
⚕️ Clinical ⚕️
In head & neck cancer survivors, a survey found the most common reasons for cannabis use were to treat pain, improve sleep, cope with stress & recreation
Characteristics of Cannabis Use Among Head and Neck Cancer Survivors
https://onlinelibrary.wiley.com/doi/pdf/10.1002/lio2.70244
For cancer-related anorexia, interviews about vaped cannabis found perceived benefits for eating
Benefits and Burdens of Vaporized Botanical Cannabis Flower Bud for Cancer-Related Anorexia: A Qualitative Study of the Experiences of People with Advanced Cancer Enrolled as Inpatients in a Phase I/IIb Clinical Trial and Their Family Carers
https://www.liebertpub.com/doi/abs/10.1177/10966218251372439
For humans running 2 miles, CBD didn’t improve their time but reduced their rating of perceived exertion by 8% & increased feelings of calm & relaxation
The Effects of an Acute Dose of Cannabidiol on Health and Two-Mile Time Trial Performance—A Pilot Study
https://www.mdpi.com/2072-6643/18/1/29
In people receiving methadone or buprenorphine for opioid use disorder, CBD modulated their pain sensitivity
Exploring the effects of cannabidiol on pain sensitivity using quantitative sensory testing among individuals receiving methadone or buprenorphine for opioid use disorder: an open-label, proof-of-concept study
https://www.sciencedirect.com/science/article/pii/S2352853225000720
In the seizures from Lennox-Gastaut syndrome, a meta-analysis of CBD found no significant difference from placebo in reducing seizure frequency, but higher levels of diarrhea, somnolence, reduced appetite, vomiting & liver enzyme changes
META-ANALYSIS OF CANNABIDIOL TREATMENT FOR SEIZURES ASSOCIATED WITH LENNOX-GASTAUT SYNDROME
https://farmaciajournal.com/wp-content/uploads/art-02-R-Xu-Qiu_823-832.pdf
I must say, in all of my years of gathering cannabinoid science, this Chinese analysis is the first one I remember saying that CBD was no help for seizures.
For cannabis & alcohol consumption, a new laboratory co-administration test found cannabis self-administration was associated with a significant reduction in the number of drinks & less cravings
Cannabis administration is associated with reduced alcohol consumption: Evidence from a novel laboratory co-administration paradigm
https://www.sciencedirect.com/science/article/abs/pii/S0376871625003138
In people with alcohol use disorder, they had:
- lower levels of CB1 receptors in their prefrontal cortex (PFC) & nucleus accumbens (NAc) (a reward center & regulator of feeding, stress & motivation)
- lower CB2 receptor levels in both regions
- lower FAAH enzyme (which breaks down anandamide) in the PFC & higher in the NAc
-lower MAGL enzyme (which breaks down 2-AG) in the NAc
Endocannabinoid system gene expression in mesocorticolimbic brain regions of individuals with alcohol use disorder: A descriptive study
https://pubmed.ncbi.nlm.nih.gov/41424074/
In people with adverse childhood experiences, there was a moderate positive relationship with later cannabis use
INVESTIGATING THE IMPACT OF EARLY ADVERSE EXPERIENCES ON SUBSEQUENT CANNABIS USE AMONG ADULTS
https://www.researchgate.net/publication/399074109_INVESTIGATING_THE_IMPACT_OF_EARLY_ADVERSE_EXPERIENCES_ON_SUBSEQUENT_CANNABIS_USE_AMONG_ADULTS
In people taking the tricyclic antidepressant amitriptyline, 30 mg of CBD significantly increased the blood levels of the drug, but not nortriptyline or tramadol
Low-dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study
https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1002/bcp.70415
For the effects of cannabis use on postoperative pain, a review of 42 studies found that some studies reported cannabis users having higher postoperative pain, some studies found no difference & split results on whether they required more opioids or not
Preoperative cannabinoid exposure and postoperative pain: A narrative review
https://www.sciencedirect.com/science/article/abs/pii/S0952818025003587
For the bioavailability of a nano-CBD solution, a clinical trial found a full stomach significantly increased absorption
A randomized, single-dose, single-sequence, two-arm (fasting and fed), open-label study on the oral pharmacokinetics of a nanodispersible cannabidiol solution (150 mg/mL)
https://karger.com/mca/article-pdf/doi/10.1159/000550104/4482914/000550104.pdf
🧬 Sleep 🧬
If I have one evergreen piece of advice, it’s that the cannabinoids affect everyone’s asleep differently. The only way to find out what works for you is by self-experimentation. Start with CBD, move on to THC & do not forget to try oleamide (the endocannabinoid of sleep induction).
In the sleep of chronic cannabis users, they had higher waking after sleep onset, lower sleep efficiency & lower total sleeping time
Chronic cannabis use and sleep architecture
https://academic.oup.com/sleep/advance-article/doi/10.1093/sleep/zsaf396/8382912
For sleep quality after starting medical cannabis, global sleep quality scores were higher
Changes in sleep quality during the 12 months following medical cannabis initiation
https://link.springer.com/article/10.1186/s42238-025-00376-7
For insomnia, a review of THC & cannabis
Medical cannabis and insomnia: a review
https://www.magonlinelibrary.com/doi/abs/10.12968/bjnn.2024.0011
In mice with sleep fragmentation, the endocannabinoid oleoylethanolamide reversed the behavioral deficits & enhanced synaptic plasticity
Oleoylethanolamide supplement attenuates postweaning sleep fragmentation-induced social behavioral deficits via inhibiting hippocampal microglial reactivity in adult mice
https://www.sciencedirect.com/science/article/abs/pii/S0889159125004738
🧬 Genes & Greens 🧬
In people with schizophrenia & heavy cannabis use, a genetic analysis found that while genetic tendencies for both cannabis use disorder & schizophrenia were associated with heavy cannabis use, the contribution from the schizophrenia genetic tendencies were only very modest, while in people with a genetic tendency towards cannabis use disorder, there was an association with schizophrenia (my video here)
Investigating the polygenic relationship between heavy cannabis use and schizophrenia in the All of Us Research Program
https://pubmed.ncbi.nlm.nih.gov/41403271/
“Polygenic liability to CUD was associated with SCZ in individuals without a documented history of cannabis use, suggesting widespread pleiotropy.”
As in, people with schizophrenia tend already have a baked in genetic tendency towards also having cannabis use disorder.
In people with cannabis use disorder, an epigenetic study of the methylation (turning off of a gene) found their dopamine-promoting regions associated with personality dimensions as well as cannabis use disorder linked to higher neuroticism, anxiety & openness plus lower agreeableness & conscientiousness
Methylation Status of the DAT1 Dopamine Transporter Gene in Individuals With Cannabis Use Disorder: Associations With Personality Traits
https://pubmed.ncbi.nlm.nih.gov/41404997/
“Importantly, reduced DAT1 [dopamine transporter gene] methylation was a significant predictor of CUD.”
In a genetic analysis, a genetic liability towards cannabis use disorder, major depressive disorder & pain was associated with heavier cannabis use
Polygenic prediction of cannabis-related outcomes over time: Evidence from the ALSPAC longitudinal cohort and the EU-GEI case-control study
https://www.researchsquare.com/article/rs-8359813/v1
The Acids
For the major acidic cannabinoids (THCA, CBDA & CBGA), an analysis of the metabolites formed in the body
The Mapping of Physiological Conversion Pathways from the Major Acidic Cannabinoids
https://www.preprints.org/manuscript/202512.1899
For the bioavailability of CBDA, multiple lines of evidence point to it being much more bioavailable than CBD as well as its bioavailability being enhanced by the presence of terpenes
Unlocking the resorption potential of cannabidiolic acid: A comprehensive in vitro and in vivo bioavailability study
https://www.sciencedirect.com/science/article/abs/pii/S0378517325009470
And for the acidic cannabinoids, on their modulation by stomach acid, blood pH & liver metabolism
The Interaction of Stomach Acid, Blood pH, and Liver Metabolism with Acidic Cannabinoids: Partial Decarboxylation, Metabolic Transformation, and Physiological Implications
https://www.preprints.org/manuscript/202512.1465
On increasing CBGA production with the addition of cyclodextrin
Integrated cascade biocatalysis of cannabigerolic acid through cyclodextrin-mediated stabilization and prenyltransferase engineering
https://www.sciencedirect.com/science/article/abs/pii/S0960852425011575
📑 Reviews 📑
For the effects of CBD & THC on our liver enzymes that process drugs, a review of the effects on the CYP450 isozymes
The Influence of CBD and THC on Hepatic Enzymes of the Human Cytochrome P450 Complex Family: A Systematic Literature Review
https://pubmed.ncbi.nlm.nih.gov/41417208/
And for CBD & liver enzymes, a review of the interactions
Elevated Concerns about Cannabidiol and Liver Enzymes
https://www.researchgate.net/profile/Rehan-Naqvi-3/publication/398917812_International_Journal_of_Clinical_Case_Studies_Elevated_Concerns_about_Cannabidiol_and_Liver_Enzymes/links/69470d197e61d05b5310f75d/International-Journal-of-Clinical-Case-Studies-Elevated-Concerns-about-Cannabidiol-and-Liver-Enzymes.pdf
And a case report of cannabis oil increasing liver enzyme levels
Unveiling the Unexpected: A Case of Synergistic Drug Reaction to Cannabidiol
https://assets.cureus.com/uploads/case_report/pdf/376593/20250925-446192-tezoeq.pdf
For high-THC products & mental health, this review of 99 studies found links to psychosis, schizophrenia & cannabis use disorder & in non-therapeutic studies, links to anxiety & depression, but also benefits for anxiety & depression
High-Concentration Delta-9-Tetrahydrocannabinol Cannabis Products and Mental Health Outcomes: A Systematic Review
https://www.acpjournals.org/doi/abs/10.7326/ANNALS-24-03819
In ADHD, a review of the involvement of the endocannabinoid system
Biochemical Role of the Endocannabinoid System in the Pathophysiology of Attention Deficit Hyperactivity Disorder: A Narrative Review and Future Directions
https://link.springer.com/article/10.1007/s11064-025-04636-z
For CBD in neurology, a review found the best evidence for severe treatment-resistant epilepsy & more limited evidence for neuropathic pain, Alzheimer’s & Parkinson’s
Cannabidiol in Neurology: Current Insights and Translational Perspectives
https://www.preprints.org/frontend/manuscript/b74382dbcfdf8a05c0be3a9377c69bb8/download_pub
In people with treatment-resistant epilepsy, a review on how to use CBD
Practical approach to the safe use of cannabidiol in patients with refractory epilepsy: a mini review
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1681815/full
For Alzheimer’s disease, a review on the endocannabinoid system for managing neuropsychiatric symptoms
The role of the endocannabinoid system in managing Neuropsychiatric Symptoms in Alzheimer’s Disease
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1709266/abstract
And in Alzheimer’s disease, a review of how cannabinoids modulate autophagy (cellular recycling)
Exploring cannabinoid modulation on autophagy mechanisms in Alzheimer’s disease: A review
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1748368/abstract
For cannabis & chronic musculoskeletal pain, a review of the evidence
The Evidence for Medical Cannabis in Chronic Musculoskeletal Pain Management
https://surgicoll.scholasticahq.com/article/138573
For cannabinoids & cavities, on the therapeutic potential of CBD, CBG & CBC
The Relationship Between Dental Caries And Cannabinoid Compounds
https://ukrpublisher.com/wp-content/uploads/2025/12/UKRJMMR-23-2025.pdf
⚠️ Harms ⚠️
For cannabis & heart health, a review found mixed associations between THC use & heart attacks, strokes & major adverse cardiovascular events, with a stronger association for atrial arrhythmias (irregular heartbeat)
Cannabis effects on cardiovascular health: Current evidence, gaps in knowledge, and future research directions
https://www.sciencedirect.com/science/article/abs/pii/S1050173825001604
In people with alcohol & cannabis dependence, both groups had significantly elevated emotional dysregulation with the cannabis users having greater difficulties in emotional awareness & lack of emotional clarity
COMPARATIVE ANALYSIS OF EMOTION REGULATION IN PATIENTS WITH ALCOHOL AND CANNABIS DEPENDENCE SYNDROME
https://www.academicmed.org/Uploads/Volume7Issue6/121.%206329.%20JAMP_Sumit_653-659.pdf
In cannabis use disorder research, a review found people of color had a heightened prevalence & unique risk factors, but were significantly understudied
Racial diversity in cannabis use disorder research: A systematic review
https://www.sciencedirect.com/science/article/abs/pii/S0376871625004612
On cannabinoid hyperemesis syndrome, a review of diagnosis & treatment
Unraveling the Enigma of Cannabinoid Hyperemesis Syndrome: A Narrative Review of Diagnosis and Management
https://assets.cureus.com/uploads/review_article/pdf/324453/20250924-371564-tezoeq.pdf
In young people with cannabinoid hyperemesis syndrome, a grand rounds on treatment
Management of Cannabinoid Hyperemesis Syndrome in Adolescents and Young Adults
https://www.jpeds.com/article/S0022-3476(25)00507-4/abstract
For HHC & hexahydrocannabiphorol, a Czech study of poisoning reports from their toxicological center
Hexahydrocannabinol and Hexahydrocannabiphorol Poisonings: Data From the Czech Toxicology Information Centre and Effects of Legislative Changes
https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.70162
“Notably, 39 children under 15 years constituted 19% of the cases. The primary exposure routes were ingestion (196 cases; 67.5%) and inhalation via smoking or vaping (62 cases; 31.5%). The clinical manifestations included neurological (74%), cardiovascular (43.1%), gastrointestinal (42.6%), psychiatric (21%), ocular (24.9%), and metabolic symptoms (14.7%).”
🐁 Preclinical 🐁
In a mouse model of neurotoxicity, CBD mitigated anxiety-like behaviors, modulated the oxidative stress response, reduced inflammatory cytokines & improved neural plasticity via BDNF (a key brain growth factor)
Cannabidiol as a Neuroprotective Agent in Acrylamide-Induced Neurotoxicity: Effects on Oxidative Stress, Inflammation, and Cholinergic Function in Male Mice
https://pubmed.ncbi.nlm.nih.gov/41395773/
In a mouse model of liver injury, CBD inhibited oxidative stress, inflammation, apoptosis (programmed cellular suicide) & damage to the mitochondria (powerhouse of the cell) via protection of the hepatic mitofusin-2 (MFN2) protein
Cannabidiol attenuates the LPS/D-Galactosamine-induced acute liver injury by inhibiting parkin-mediated ubiquitination of MFN2
https://www.sciencedirect.com/science/article/abs/pii/S037887412501760X
In a mouse model of inflammation, CBG lowered inflammatory cytokines
Cannabigerol Exerts In Vivo and In Vitro Anti-Inflammatory Effects via Inhibition of the MAPK and NF-κB Pathways
https://pubmed.ncbi.nlm.nih.gov/41423277/
In fruit flies being fed CBD, their tolerance to alcohol rose less quickly
Long term exposure to dietary cannabinoids inhibits rapid functional tolerance to ethanol in Drosophila melanogaster adults
https://www.micropublication.org/static/pdf/micropub-biology-001825.pdf
In rats taking delta-8 THC, an analysis of how it moved through their system & the metabolites created
Pharmacokinetic Study of Delta-8-Tetrahydrocannabinol in Male Rats using a Validated Bioanalytical Method
https://academic.oup.com/jat/advance-article-abstract/doi/10.1093/jat/bkaf105/8382613
In a fruit fly model of seizures, CBD caused anticonvulsant activity
Seizure Susceptibility in Drosophila melanogaster is Reduced with CBD and Z. jujube treatment
https://www.micropublication.org/static/pdf/micropub-biology-001799.pdf
In human skin exposed to pollution, CBD lowered inflammation, oxidative stress & barrier damage
Cannabidiol Mitigates Pollution-Induced Inflammatory, Oxidative, and Barrier Damage in Ex Vivo Human Skin
https://www.mdpi.com/2218-273X/16/1/10
🆕 Novel Studies 🆕
(my grab bag section for stuff I haven’t quite seen before)
In a Canadian analysis of the illicit market, there were higher levels of heavy metals, pesticides, mycotoxins & microbial contaminants
Quantification of THC, heavy metals, pesticides, mycotoxins, and microbial contaminants in cannabis inflorescence reveals higher levels in illicit samples than in the licensed Canadian market
https://www.researchsquare.com/article/rs-8186487/v1
Across 105 tissue types, a comparative analysis of how THC & CBD altered genetic transcription
Comparative analysis of 105 datasets across species and tissues reveals differential transcriptomic responses to cannabinoids THC and CBD
https://link.springer.com/article/10.1186/s42238-025-00361-0
“CBD datasets clustered more tightly by route of administration and species and were more frequently enriched for pathways related to zinc homeostasis, inflammation suppression, and cell cycle regulation. In contrast, THC signatures were more heterogeneous and did not exhibit consistent clustering, although consistently altered genes associated with antioxidant activity, neuronal myelination, synaptic signaling, and transcriptional regulation were identified across datasets. THC altered endocannabinoid signaling genes more often in brain tissues, while CBD affected this pathway more heavily in both central and peripheral tissues. Disease enrichment analyses revealed significant associations of CBD DEGs with lipid metabolism and body composition traits, while DEGs of both compounds showed links to neuropsychiatric disorders and type 2 diabetes.”
Identification of a new synthetic cannabinoid in the wild: MDMB-5’Br-PINACA
Identification and Structural Elucidation of a New Synthetic Cannabinoid, MDMB-5’Br-PINACA, in Seized Herbal Materials
https://pubmed.ncbi.nlm.nih.gov/41403075/
And in France, on the emerging synthetic cannabinoid 5F-AKB48 (aka Buddha blue or PTC (‘pète ton crâne’ [blow your skull])
5F-AKB48: A synthetic cannabinoid presenting an emerging public health concern in France
https://www.sciencedirect.com/science/article/abs/pii/S0955395925002683
📰 US Headlines & Fav Articles 📰
For 2026 events in the US & EU, a guide from CelebStoner
https://www.celebstoner.com/reviews/concerts-and-events/2026/01/01/celebstoners-cannabis-industry-events-guide-2026/
For Biden’s cannabis pardons, a House Oversight inquiry seeks to invalidate them because an autopen was used
https://www.marijuanamoment.net/gop-committee-chair-wants-to-invalidate-bidens-marijuana-pardons-through-autopen-investigation-democratic-congressman-says/
The USDA is blocking cannabis companies from a loan program
https://www.marijuanamoment.net/feds-defend-decision-to-block-companies-that-work-with-marijuana-industry-from-participating-in-loan-program/
In Oklahoma, physicians now cannot recommend cannabis without first registering with the state cannabis authority
https://eu.oklahoman.com/story/news/drugs/marijuana/2025/12/31/new-oklahoma-marijuana-law-requires-physicians-to-register-with-omma/87972457007/
#LessBarriers
In Maine, medical cannabis will be taxed at the general rate
https://news.bloombergtax.com/daily-tax-report-state/maine-revenue-services-issues-revised-instructional-bulletin-updating-sales-tax-guidelines-for-medical-cannabis-products
Listen, if there’s anything that should not be taxed, it’s this medicine.
In Maryland, Howard County firefighters will now be able to use medical cannabis while off duty
https://cannabislaw.report/md-newly-updated-policy-will-allow-howard-county-firefighters-to-use-medical-cannabis-while-off-duty-in-2026/
In Kentucky, the first medical cannabis dispensaries sold out in 7 days
https://spectrumnews1.com/ky/louisville/news/2025/12/30/medical-cannabis-sold-out
In Minnesota’s Twin Cities, one-third of underaged buyers in undercover study allowed to purchase hemp-derived THC
https://www.minnpost.com/state-government/2025/12/undercover-young-customers-went-uncarded-buy-hemp-derived-thc-in-twin-cities/
Dame Alice O’Leary Randall begins a year-long project on the history of the medical cannabis movement
https://aliceolearyrandall.substack.com/p/medical-marijuana-at-50-a-lived-history
An interview with Alejandra Contreras, founder of Cannaphilia, Sexuality and Cannabis
Conversación con la activista cannábica Alejandra Contreras, fundadora del proyecto Cannafilia, Sexualidad y Cannabis
https://www.scielo.org.mx/scielo.php?pid=S2448-57052025000300137&script=sci_arttext_plus&tlng=es
Book of the Week: ‘How I Got You Your Ounce: Inside New York’s Apartment-Dealer Era’ (reviewed by Javier Hasse)
https://hightimes.com/culture/how-i-got-you-your-ounce-inside-new-yorks-apartment-dealer-era/
I just got the e-book & I’ve been enjoying this straightforward account of local dealing in my old beloved home of the Rotten Apple.
Ha! Love this video of Tasmanians in 1971 & their opinions on legalizing cannabis, especially the little old lady at 2’37”
(hattip to the excellent Sean Hocking at the Cannabis Law Report)
https://www.abc.net.au/news/2025-12-22/tasmanians-in-1971-speak-about-legalising-cannabis/106092878
History Corner: the Marihuana Tax Act of 1937 & popular misconceptions of its passage
Correcting popular misconceptions about the origins of the Marihuana Tax Act of 1937
https://pubmed.ncbi.nlm.nih.gov/41402137/
The book to read is ‘The American Disease: Origins of Narcotic Control’ by Dr. David Musto (free online).
🌐 International Updates 🌐
In the United Arab Emirates, a new decree regulates the industrial & medical uses of hemp
https://www.wam.ae/en/article/bn9xtbw-uae-government-issues-federal-decree-law
In southern Africa, a solid analysis of the state of cannabis medicine
https://cannabislaw.report/article-the-state-of-cannabis-based-medicine-in-southern-africa/
In Morocco, a policy analysis of their cannabis liberalization
Navigating Cannabis Regulation in Morocco: Historical Context, Socio-Economic Impact, and Policy Gaps
https://jied.lse.ac.uk/articles/10.31389/jied.276
🚓 The War on Drugs 🚓
An excellent deep dive on Marco Rubio & the long US history of installing & supporting narcotraffickers in presidencies of the Americas
https://prospect.org/2025/12/23/narco-terrorist-elite-rubio-south-america-iran-contra/
Of course, this is particularly relevant with the recent arrest of Venezuela’s Maduro as one more example of the War on Drugs as a useful political tool for US imperialism.
More boat strikes kill 9 as the Coast Guard searches for survivors + a strike on a boat-loading facility
https://www.npr.org/2025/12/31/g-s1-104194/us-military-strikes-drug-boats-survivors
https://kutv.com/news/nation-world/us-coast-guard-still-searching-for-alleged-narco-terrorists-who-jumped-off-boats-vessels-attacks-drugs-narcotics-mexico-guatemala-survivors-venezuela-attack-drugs-narcotics-drug-vessels-designated-terrorist-organizations-president-donald-trump
https://www.aol.com/articles/u-military-says-strike-alleged-041810663.html
https://www.reuters.com/world/us/us-venezuelan-officials-still-mum-trumps-mention-action-against-drug-boat-2025-12-29/
And on a boat washing up on shore showcases the local ramifications for life and death
https://www.nytimes.com/2025/12/29/world/americas/trump-boat-strikes-gulf-of-venezuela-wreckage.html
And an excellent analysis of this awful spectacle of extrajudicial murder of the most powerless of people
https://canadiandimension.com/articles/view/extrajudicial-killing-in-the-age-of-spectacle
“In a paper from 2016, lawyer Kevin Lerman points out that drug mules are “pawns of the drug conspiracies” representing the lowest rung of the narcotics trade. Similarly, writes University of London professor Jennifer Fleetwood, couriers are the “most powerless and most exploited in the international drug trade,” typically snared into the web of the cartels by poverty, debt or coerced into collusion. If caught, cartel bosses will vigorously disown them and not waste a penny on their legal defence. These readily replaceable mules now fill US prisons while narco lords and their financial kingpins, with few exceptions, have faced little or no repercussions. The fragmented evidence on the profiles of the mules now being blown apart by US military power largely echoes this depiction: fisherman and migrants from coastal regions of Venezuela struggling in poverty with few alternatives to provide for their families…
Alessandro Manzoni’s novel, The Beloved, offers a powerful meditation on the plight of those caught in the crosshairs of such as system: “the law was like a net spread to catch the little birds, while the great ones broke through it and flew away… the poor were punished for trifles, while the rich committed crimes with impunity.” His words still resonate in our time.”
Relatedly, just last month I happened to listen to Manzoni’s supremely excellent book aka as ‘The Betrothed’ & made a video about it (as well as an I Ching quote book). It’s a 200-year-old book that’s sometimes called the ‘War & Peace’ of Italy & its meditations on power & personalities perfectly maps on to today’s drug wars & who gets ground under the boot.
Oh, and the plague comes back in that one too. Very modern.
The DEA proposed scheduling the synthetic cannabinoids 4F-MDMB-BUTICA, ADB-4en-PINACA, 5F-EDMB-PICA & MMB-FUBICA
https://www.federalregister.gov/documents/2025/12/16/2025-22963/schedules-of-controlled-substances-placement-of-4f-mdmb-butica-adb-4en-pinaca-5f-edmb-pica-and
The game of whack-a-mole continues apace…
‘The War on Drugs Was a War on Black Mothers’
https://msmagazine.com/2025/09/29/war-on-drugs-black-mothers-crack-baby/
Final chapter of the Psychonaut File on Gordon Todd Skinner & his relation to the Pickard/LSD missile silo bust
https://psychonautfiles.substack.com/p/concluding-the-files
A report on fentanyl & meth trafficking to the US by the Government Accountability Office
https://www.gao.gov/products/gao-26-107918
And the Filter snarky about how they went undercover to almost buy drugs
https://filtermag.org/gao-synthetic-drug-trafficking-financing/
On the last 10 year of Latin America’s cannabis market, with Paraguay flooding the Southern Cone & on the effects of legalization by Insight Crime
https://insightcrime.org/news/gamechangers-2025-10-year-evolution-latam-marijuana-market/
Catalonia losing its status as a major European cannabis production center as market shifts to imports from Canada & Thailand
https://cannabislaw.report/media-report-catalonia-being-drowned-in-imported-black-market-cannabis-lawyers-accustomed-to-dealing-with-drug-lords-also-know-this-well-the-marijuana-business-is-over-the-market-is-shifting/
“’In Vidreres and Maçanet, there are housing developments where every other house has a cannabis plantation inside,’ explain the police.”
In Portugal, more than 100 public officials arrested for drug & human trafficking since 2020
https://cannabislaw.report/portugal-more-than-100-public-officials-arrested-since-2020-for-links-to-drug-and-human-trafficking-networks/
In Morocco, 8 tons of hashish seized at the Tangier port
https://cannabislaw.report/moroccan-authorities-seize-over-8-tons-of-hashish-at-tangier-med-port/
In Spain, ‘vuelcos’ caught stealing 2 tons of hashish from rival traffickers
https://cannabislaw.report/spain-rival-gang-attempts-to-steal-two-tonnes-of-hashish-from-drug-traffickers-on-the-costa/
Here’s the definition of vuelcos as gangs that rob other gangs. And if you don’t know the Omar Little reference at the top, know that the Wire is the ‘War & Peace’ of our generation & one of the single best pieces of work I know on the insanities & horrors of the War on Drugs.
For the effects of police crackdown on illegal online cannabis sales, an analysis found that the effects lasted for several weeks & compromised the trust system of cryptomarkets
The effect of a police crackdown on online drug sales: on the importance of targeting vendors’ reputation?
https://www.sciencedirect.com/science/article/pii/S0955395925004098
For drug deaths in the United Kingdom from novel psychoactive substances, the local controls were not as effective in reducing availability as were the restrictions in China
The Relative Impact of UK and Chinese Drug Controls on NPS Detections in Deaths in England, Wales and Northern Ireland
https://www.sciencedirect.com/science/article/pii/S2667118225000455
In Sweden’s open drug scene, an analysis finds that drug hotspots are a rather weak predictor of drug market-related violence but that open drug scenes are a reasonably good predictor of drug market violence
The geography of drug markets, drug crime and systemic gang violence—Open drug scenes in Sweden
https://www.sciencedirect.com/science/article/pii/S0955395925004153
In the Philippines, on how authorities dispose of drugs
BEHIND CLOSED DOORS: A QUALITATIVE EXAMINATION OF CONTRABAND DISPOSAL PRACTICES BY AUTHORITIES IN THE FIGHT AGAINST DRUG TRAFFICKING
https://cdn.epratrustpublishing.com/article/202505-01-021676.pdf
I believe one of the common techniques is selling it out the back door to your protected dealers.
On Mexico’s continued militarized approach to drug control, an analysis through the framework of “morphogenetic regulation”
Mexico’s addiction to war: a morphogenetic régulation analysis on the Mexican war on drugs
https://www.tandfonline.com/doi/abs/10.1080/14767430.2025.2589702
In Colombia’s War on Drugs, on the necropolitics enforced by US policies
The necropolitics of criminalisation in the Colombian War on Drugs
https://www.manchesterhive.com/display/9781526181848/9781526181848.00015.xml
In Nigeria, interviews of law enforcement & public health professionals on synthetic drug use
Perceptions of Law Enforcement Personnel and Public Health Professionals on Synthetic Drug Use in Nigeria
https://adiktologie-journal.eu/wp-content/uploads/2025/11/03_2-2025_25_003_Agwogie_065-076_digital.pdf
In the Philippines, interviews with drug cops on the themes of their positive & negative experiences (which sounds like the names of Taoist deities & palaces)
View of Battle Against the Drug Menace: Narratives of Law Enforcers in Implementing the Anti-Drug Program
https://al-kindipublisher.com/index.php/ijlps/article/view/11671/10444
“For the positive experiences there were two (2) themes namely: Triumph in Shared Victory and Justice in Motion: Fulfilment in Every Rescue. For the negative experiences there were two (2) themes namely: Fighting a Battle That Resets Itself and Stand Amidst the Storm. As to addressing the challenges encountered by the informanats in the implementation of the anti-drug program, there were three (3) themes namely: Leading with Resolve in the Midst of Limitations; Presence with Purpose and Unity in Action. For the impact of the implementation of the anti-drug program to the peace and order of the community, there were two (2) themes namely: Peace Built on Persistence and Precision and Trust at the Center of Peace”
⚖️ Business, Laws & Education ⚖️
On the LA underground cannabis scene through the lens of black radical theory, disability studies & Buddhist humanist geography
Cannabis and the Undercommons of Care: Producing Fugitive Value in Punitive Los Angeles
https://acme-journal.org/index.php/acme/article/view/2265
For state cannabis policies, an analysis of their characteristics in the bundles of pharmaceutical (treating it like a regulated pharmaceutical), permissive (treating it like an over-the-counter product) & fiscal (treating it as a way to raise revenue)
Measuring State Cannabis Policy Design Variation for Research and Policy: A Bundles Approach
https://www.sciencedirect.com/science/article/abs/pii/S014929182500270X
For California legalization (Prop 64), interviews with experts found 3 themes:
1. Successes: quality control, justice reform, stigma reduction
2. Shortcomings: high cost, licensing, bureaucracy, social inequity
3: Recommendations for improvement: need for research, policy change, the transformation of the business model
The Impact of Adult Cannabis Use Legalization in California: A Qualitative Review of Subject Matter Expert Opinions on Proposition 64
https://pubmed.ncbi.nlm.nih.gov/41278424/
For cannabis legalization in California, a thesis project with ~100 interviews on NIMBY sentiments & the uneven distribution of benefits
Cannabis Legalization in California: A Critical View on Socio-Legal Change
https://escholarship.org/uc/item/48q0j9m2
In Brazil, a product analysis of compliance with sanitary laws
Sanitary regulation of Cannabis-derived products authorized for importation in Brazil: Characteristics and regulatory trajectory
https://www.scielosp.org/article/sdeb/2025.v49n147/e10408/en/
For consumer interest in hemp fashion, a survey found the determinants included attitudes toward hemp-based fashion products, subjective knowledge, perceived social & functional value, fashion involvement & attitudes toward marijuana legalization
Identifying and Characterizing Potential Hemp Fashion Consumers: A Supervised and Unsupervised Statistical Learning Approach
https://www.iastatedigitalpress.com/itaa/article/id/21524/
& for hemp fabrics, a thesis on consumer willingness to pay
Consumer Preferences and Willingness to Pay for Hemp-Blend Fabric Item
https://repository.lsu.edu/gradschool_theses/6269/
🚗 Driving 🚗
For cannabis-involved fatal crashes, an analysis with 6 distinct crash clusters
Uncovering contextual risk patterns in cannabis-involved fatal crashes: A data-driven approach to public health-oriented road safety
https://www.sciencedirect.com/science/article/pii/S0022437525001987
For people driving under the influence of cannabis and/or alcohol, an analysis of their characteristics
Driving under the influence of alcohol and cannabis: Associations with substance use and behavioral health characteristics
https://www.tandfonline.com/doi/abs/10.1080/15389588.2025.2587850
For cannabis & driving, a survey found the majority expressed skepticism about law enforcement’s ability to detect cannabis impairment accurately & felt that driving under the influence of cannabis should carry different legal penalties than drunk driving
Driving under the influence of cannabis: What users think and why it matters
https://www.sciencedirect.com/science/article/abs/pii/S1369847825002852
Among Canadian youth, a smartphone intervention reduced their cannabis-impaired driving
Preliminary efficacy of ‘high-alert’ a brief smartphone intervention to reduce Cannabis-impaired driving among youth: A pilot randomized controlled trial
https://www.sciencedirect.com/science/article/pii/S1369847825004449
🛡️ Harm Reduction News 🛡️
In Virginia, an excellent new university analysis on the 2k+ lives saved statewide by harm reduction
https://news.vcu.edu/article/virginia-opioid-epidemic-update
In Maine, pushback against syringe exchange hurts the fight against AIDS
https://www.sunjournal.com/2025/12/22/pushback-on-syringe-services-hurts-maines-hiv-fight-experts-say/
In London, an emerging crisis with Cychlorphine, an immensely strong new opioid
https://www.standard.co.uk/news/crime/camden-drug-deaths-cychlorphine-synthetic-opioid-b1262119.html
Harm Reduction Research
A statement supporting harm reduction vending machines from AMERSA (Association for Multidisciplinary Education and Research in Substance use and Addiction)
In Support of Harm Reduction Supply Distribution via Vending Machines: Position Statement of AMERSA, Inc. (Association for Multidisciplinary Education and Research in Substance use and Addiction)
https://amersa.org/wp-content/uploads/In-Support-of-Harm-Reduction-Supply-Distribution-via-Vending-Machines_Position-Statement-of-AMERSA-Inc_final-2.pdf
In people who use opioids in Baltimore, in the characteristics of the 3 key overdose prevention behaviors: test dosing, the locks own & solitary drug use
Naloxone Availability, Testing Drugs for Potency, and Solitary Use: Unpacking the Determinants of Overdose Prevention Behaviors
https://www.tandfonline.com/doi/pdf/10.1080/10826084.2025.2600637
To prevent fentanyl overdoses, on Texas creating a harm reduction public health campaign
“We Keep Each Other Safe”: The Development and Implementation of a Harm Reduction Health Communication Campaign to Prevent Fentanyl Overdoses
https://www.tandfonline.com/doi/abs/10.1080/10826084.2025.2605654
🍄 Psychoactives, Psychedelics & Plant Medicines 🍄
On the “zombie vapes” of Asia, as reported by Michelle Lhooq
https://ravenewworld.substack.com/p/lullabies-for-the-dispossesed
On psychedelics, opening up people’s gender identity
https://www.bbc.com/future/article/20251211-psychedelics-are-altering-how-people-see-their-own-gender-and-sexuality
Psychedelics in the extreme endurance athlete community
https://www.westword.com/news/colorado-runner-psychedelics-training-superathletes-40808593/
On the rise of psychedelic churches in the US & a short history of their legal status
https://www.theguardian.com/society/2025/dec/25/psychedelic-church-drugs-legal
On Britain’s psychedelic mushroom pickers after 20 years of fresh mushrooms being illegal
https://psychedelicpress.substack.com/p/psilocybe-pickers
The Psychoactive Research
In Belgium, an analysis of their party drugs, with MDMA still being the winner!
Seized party drugs: New substances, combination mixtures, and polydrug use
https://www.sciencedirect.com/science/article/abs/pii/S0379073825004244
In France, an analysis of the novel psychoactive substances
Novel Psychoactive Substances: Update of the French Addictovigilance Network Data
https://www.sciencedirect.com/science/article/pii/S2667118225000297
For the cathinone 3-methylmethcathinone, a clinical trial on its potential as a pain-relieving agent
Analgesic Effects of 3-Methylmethcathinone (3-MMC) in Healthy Volunteers
https://www.sciencedirect.com/science/article/pii/S2667118225000947
Ayahuasca
In a case report of psychedelic healing, ayahuasca improved mental health & altered the microbiome
Gut–Mind Interactions in Psychedelic Healing: A Case Study Assessing the Effects of Huachuma and Ayahuasca on the Mind and Microbiome
https://restorativemedicine.org/journal/gut-mind-huachuma-ayahuasca/
Psychedelics
For challenging psychedelic experiences, on considerations for managing the associated distress (by friend of the newsletter Jules Evans)
Ontologically challenging psychedelic experiences: Considerations for managing associated distress.
https://ore.exeter.ac.uk/articles/chapter/Ontologically_challenging_psychedelic_experiences_Considerations_for_managing_associated_distress_/30898091
On Canada’s cancer & psychedelic therapy program
The CAnadian Network for Psychedelic-Assisted Cancer Therapy (CAN-PACT): A Multi-Phase Program Overview
https://www.mdpi.com/1718-7729/33/1/7
For psychological well-being, meditation had a stronger association than psychedelic use
The interplay of psychedelic use and meditation in shaping psychological well-being
https://www.sciencedirect.com/science/article/pii/S1053810025001709
For people with methamphetamine use disorder, on the efficacy of psilocybin therapy
A qualitative analysis of participant expectations and experiences of psilocybin-assisted psychotherapy for methamphetamine use disorder
https://pubmed.ncbi.nlm.nih.gov/41424164/
When excluding people from psychedelic therapy, an analysis of the potentially overly stringent exclusion criteria that may limit access without justification
Eligibility for psychedelic therapy: Clinical trial medical exclusion criteria and their implications for hospital practice
https://www.sciencedirect.com/science/article/pii/S0163834325002385
For people in palliative care, a review of psilocybin
Psilocybin-assisted therapy for individuals with palliative care needs: A systematic review of safety and efficacy
https://journals.sagepub.com/doi/abs/10.1177/02692163251383335
For psychedelics & brain signaling, a review of the molecular mechanisms & functional connectivity changes
Psychedelic experiences elicited by serotonergic psychedelics: Molecular mechanisms and functional connectivity changes in the brain
https://www.sciencedirect.com/science/article/pii/S0149763425005305
For psychedelic literature, a citation analysis of 81 key publications & 10 thematic clusters
Clinical Frontiers in Psychedelic Research: A Scientometric Review of the Evolving Literature
https://www.sciencedirect.com/science/article/pii/S2667118225000431
For psychedelic assisted psychotherapy, on the mental health therapeutic effects from the Geneva University Hospital model
Psychedelic Assisted Psychotherapy (PAP): the Geneva University Hospital model
https://www.sciencedirect.com/science/article/pii/S2667118225000935
Ketamine
For obsessive-compulsive disorder, a review of using ketamine
An Oral Ketamine-Like Approach to Treatment-Resistant Obsessive-Compulsive Disorder—A Review of Mechanism, Clinical Experience, and Future Directions
https://www.preprints.org/manuscript/202512.1958
For opioid use disorder in patients with chronic pain, a review on ketamine’s therapeutic effects
Efficacy of Ketamine Infusion for Treatment of Opioid Use Disorder in Patients with Chronic Pain: a Narrative Review
https://link.springer.com/article/10.1007/s11916-025-01437-5
In using ketamine for acute suicidality, some patients responded but others did not & one case of ketamine abuse prompted protocol changes
Single fixed-dose intranasal racemic ketamine treatment for the treatment of acute suicidality in a transdiagnostic patient population: Results of a pilot study
https://www.sciencedirect.com/science/article/pii/S0165178125005542
For ketamine abuse, another case report of a kid blowing out their urinary tract
Ketamine-Induced Uropathy in Young Adults: A Case Report Highlighting Diagnostic Challenges
https://www.sciencedirect.com/science/article/pii/S266711822500073X
Kratom
In Malaysian alcohol drinkers, a survey found that some were using kratom as a substitute
Kratom (Mitragyna speciosa) as a Replacement for Alcohol Among a Sample of Malaysian Adults with a History of Alcohol Use Problems
https://www.tandfonline.com/doi/full/10.1080/10826084.2025.2600634
For kratom, a review of its neurological effects & addiction potential
From Traditional Use to Dependence: Investigating the Neurobiological Impact of Kratom and Mitragynin
https://www.sciencedirect.com/science/article/pii/S2667118225000650
🍃 The Plant & its Products 🍃
🌱 Growing & Extracting 🌱
On creating cannabis with 5 or 6 copies of its chromosomes (a pentaploid or hexaploid)
Characterization and Interploid Cross-compatibility of Hexaploid Cannabis sativa L. and Production of Pentaploids
https://journals.ashs.org/view/journals/hortsci/60/12/article-p2442.xml
this is a common agronomic technique (bread wheat is a hexaploid), but it’s never been applied it to cannabis because of prohibition.
On growing hemp in a shipping container
Development of a Controlled-environment Plant Growth Chamber Using a Shipping Container for Industrial Hemp (Cannabis sativa L.) Cultivation
https://journals.ashs.org/view/journals/horttech/36/1/article-p24.xml
For small-scale indoor cultivation, a thesis project business manual for cannabis cultivation & processing
Business manual for small scale indoor cultivation of cannabis and processing (Cannabis indica Lam. x Cannabis ruderalis Janisch)
https://repository.afs.edu.gr/handle/6000/760
For different light spectra, an analysis of cannabis growth
Evaluation of wavelength light effects on in vitro cultivation of hemp: an exploration of LED lights
https://ojs.revistacontribuciones.com/ojs/index.php/clcs/article/view/15507
On cannabis farm water access in southern Oregon, this thesis project interviewed farmers
Perspectives of Cannabis Farmers on Intersection of Water Access and Cannabis Frontier Constraints in Southern Oregon
https://pdxscholar.library.pdx.edu/open_access_etds/6975/
For cannabis grown in the deep-water culture system, on the optimization of nitrogen nutrition
Nitrogen source and solution strength modulate cannabinoid and antioxidant profiles in medicinal cannabis grown in a deep-water culture system
https://www.nature.com/articles/s41598-025-33089-1_reference.pdf
In hemp seedlings, an analysis of their flavonoid levels
The content of flavonoids in hemp seedlings
https://sciforum.net/paper/view/28284
On the leaf fungal microbiota, a Japanese field trial across different growth stages & sexes
Comparison of Leaf Fungal Endophytes between Growth Stages and Sexes of Cannabis sativa at an Experimental Field of Mie University, Japan
https://www.bio.mie-u.ac.jp/files/%E7%94%9F%E7%89%A9%E8%B3%87%E6%BA%90%E5%AD%A6%E7%A0%94%E7%A9%B6%E7%A7%91%E7%B4%80%E8%A6%8151%E5%8F%B7.pdf#page=17
For self-pollinated cannabis seeds, they had less variation in shape
Self-pollinated cannabis seeds lead to less variation in shape: a technological approach of potential commercial interest
https://link.springer.com/article/10.1186/s12870-025-07989-3
When extracting cannabinoids, a review of the progress & the future
Extraction and analysis of cannabinoids: A decade of progress, challenges and future directions
https://www.sciencedirect.com/science/article/abs/pii/S002196732500665X
On cannabinoid extraction from hemp with short-path vacuum distillation with alcoholic extracts
Experimental optimization of a short-path distillation of alcoholic extracts from hemp
https://www.sciencedirect.com/science/article/pii/S0255270125005045
On extracting terpenes from hemp with green solvents
Green solvent selection for terpene extraction from hemp
https://www.sciencedirect.com/science/article/abs/pii/S0255270125005033
For a Korean hemp cultivar, an analysis of its cannflavin levels
Agrobacterium-mediated Gene Expression Efficiency in Hemp (Cannabis sativa L.) ‘Cheungsam’ via Direct Organogenesis
https://www.cropbio.or.kr/articles/article/Prqy/
A protocol for isolating a high molecular weight DNA from cannabis for long-read sequencing
High Molecular Weight DNA Extraction from Cannabis sativa for Long-Read Sequencing
https://www.protocols.io/view/high-molecular-weight-dna-extraction-from-cannabis-hhvkb364x.pdf
⚙️ Analyzing & Formulating ⚙️
In quality testing of CBD oils, on testing for hazardous compounds with an HPLC & planar bioassays
Unmasking hazardous compounds in cannabidiol-containing oils using planar bioassays and high-resolution mass spectrometry
https://www.sciencedirect.com/science/article/pii/S0039914025017643
On analyzing for 25 cannabinoids using liquid chromatography with absorbance detection
An In-Depth Study Evaluating the Determination of CBD, Δ9-THC, Δ8-THC, and 25 Additional Cannabinoids in Cannabis Concentrates by Liquid Chromatography with Absorbance Detection
https://link.springer.com/article/10.1007/s10337-025-04464-x
On measuring cannabinoid levels using an LC-MS/MS
Cannabinoids in Cannabis sativa l. and oil: Method validation and analysis by LC-MS/MS
https://www.sciencedirect.com/science/article/abs/pii/S0379073825004256
For hashish, on measuring cannabinoid levels using electroanalytical determination
Electroanalytical determination of cannabinoids in hashish samples for future implementation in electrochemical sensors
https://iris.unimore.it/handle/11380/1392028
For quantifying nano-CBD in powder form, on developing an HPLC-UV method
Development of HPLC–UV Method for Quantitative Analysis of Cannabidiol Encapsulated in Lipid Nanoparticle Powder
https://nano-thailand.com/2025/wp-content/uploads/2025/12/eProceeding-nanothailand-vol1.1.pdf#page=51
For on-site measurement of cannabinoids, a thesis project on a portable electrochemical system
Portable electrochemical sensoristic system for the on-site measurement of cannabinoids
https://iris.unimore.it/handle/11380/1392029
For producing a 1:1 THC: CBD oil, a Macedonian validated process
VALIDATION OF PRODUCTION AND PACKAGING PROCESS OF CANNABIS OIL 25:25 THC:CBD (25MG/ML THC: 25MG/ML CBD)
https://ojs.ikm.mk/index.php/kij/article/view/7961
On encapsulating the terpene D-limonene with hemp protein isolate & gum Arabic
Microencapsulation of D-limonene through non-covalent coacervates of hemp protein isolate and gum Arabic
https://www.sciencedirect.com/science/article/abs/pii/S0260877425003206
🍞 Food, Nutrition & Hemp Seeds 🍞
For hemp seeds, a review of their nutritional support for the endocannabinoid system
Hemp Seeds: The Nutritional Support for the Endocannibinoid System (ECS)
https://www.preprints.org/manuscript/202512.1980
In cows fed hemp, the terpenes transferred into their milk
Terpene transfer to milk from fresh leaves of hemp (Cannabis sativa L.) and savory (Satureja hortensis L.)
https://www.sciencedirect.com/science/article/pii/S0022030225010355
When combining maltodextrin & hemp protein isolate, on an ultrasound-intensified wet-heating technique
Ultrasound-intensified wet-heating induced Maillard reaction between hemp cake protein and maltodextrin: Structural characterisation, techno-functional and antioxidant properties
https://www.sciencedirect.com/science/article/pii/S1350417725003153
🏗️ Industrial Uses & Fiber 🏗️
On using hemp stocks to produce nanographene zinc oxide nanocomposites for CO2 capture
Boosting the CO2 capture and regeneration performance by nanographene@zinc oxide as novel green-synthesized nanocomposites
https://www.sciencedirect.com/science/article/abs/pii/S1226086X25005787
When cleaning heavy metals from the soil with hemp (or sorghum), humic substances improved yield & soil quality
Beneficial effects of commercially available preparations of humic substances and mycorrhiza on growth and photosynthesis of sorghum and hemp cultivated on a metal(loid)-polluted field
https://link.springer.com/article/10.1007/s11104-025-07816-6
On acoustic insulation made from industrial hemp residues
Development, Production, and Characterization of Acoustic Insulation Components Made from Industrial Residues
https://www.tandfonline.com/doi/pdf/10.1080/15440478.2025.2598610
On creating an aerogel from hemp straw with cellulose-silica
Highly flexible cellulose-silica composite aerogels from hemp straw
https://www.sciencedirect.com/science/article/pii/S0926669025020588
On creating a hydrophobic foam derived from hemp seed oil
High-Performance Oil–Water Separation Using an Additive-Free, Hemp Seed Oil-Based Inherently Hydrophobic Polyurethane Foam
https://onlinelibrary.wiley.com/doi/abs/10.1002/app.70186
On creating a walnut shell biochar composite reinforced with hemp fiber
Valorization of walnut shell biochar in hemp fibre reinforced isosorbide epoxy/eugenol benzoxazine copolymer composites: physical, water absorption, mechanical, and thermal properties
https://link.springer.com/article/10.1007/s00289-025-06234-z
On improving hemp fiber performance with alkali treatment & nano dip-coating
Investigation of mechanical, thermal, and wettability behavior of multiwalled carbon nanotube coated hemp fibers
https://iopscience.iop.org/article/10.1088/2631-8695/ae2dc2/meta
For hemp straw used as a fiber, on the effects of the cultivar, harvest & fibers extraction method
EVALUATION OF FLAX AND HEMP STRAW OBTAINED FROM FIBROUS PLANTS INTENDED FOR PROCESSING FOR TEXTILE PURPOSES
https://cdr.gov.pl/images/ZDR/2025/ZDR-2025-4.pdf#page=10
For a hemp fiber polymer composite, an analysis of its strength characteristics
STRENGTH CHARACTERISTICS OF HEMP FIBER POLYMER COMPOSITE
https://acervojournal.org/wp-content/uploads/Vol-06-Issue-06-12.pdf
On creating a zero-carbon microhome prototype using hemp
Integrating hemp in a replicable model for affordable, low carbon housing: a zero carbon microhome prototype for the Kansas Flint Hills
https://www.frontiersin.org/journals/sustainability/articles/10.3389/frsus.2025.1606205/full
On creating insulation material with hemp mesh & panels
Sustainable reinforcement strategy for green insulation panels: Evaluation of hemp mesh geometry and natural coatings
https://www.sciencedirect.com/science/article/pii/S2352710225020406
On creating sandwich cores reinforced with particulate hemp powder
Numerical and Experimental Study on Dynamic Response of Sandwich Beams With Particulate Hemp-Reinforced PLA Bio-Inspired Cellular Cores
https://onlinelibrary.wiley.com/doi/full/10.1002/eng2.70557
For hempcrete, an analysis of the effects of the distribution & orientation of hemp shives & the hemp microstructure
Thermal and mechanical properties of hempcrete with low-carbon binders: Effects of 3D distribution and orientation of hemp shivs and microstructures of hempcrete
https://www.sciencedirect.com/science/article/pii/S235271022502100X
In hemp-based blocks, on AI optimization for compressive strength
Artificial Intelligence-Powered prediction and optimization of compressive strength in lightweight hemp-based blocks for sustainable construction
https://link.springer.com/article/10.1007/s11709-025-1250-z
🌿 THE CANNA-SCIENCE ARCHIVE 🌿
In hemp, a review of the 100+ bioactive compounds
Bioactive Compounds of Hemp (Cannabis sativa L.): A Review of Their Potential Therapeutic Applications
https://www.researchgate.net/profile/Zohaib-Younas/publication/398870263_Bioactive_Compounds_of_Hemp_Cannabis_sativa_L_A_Review_of_Their_Potential_Therapeutic_Applications/links/69456d9306a9ab54f8487daa/Bioactive-Compounds-of-Hemp-Cannabis-sativa-L-A-Review-of-Their-Potential-Therapeutic-Applications.pdf
An editorial on developing botanical drugs from cannabis
Letters From the Field: Challenges and Opportunities in the Development of Botanical Drugs From Cannabis
https://www.sciencedirect.com/science/article/abs/pii/S0149291825004072
🏥 Public Health, Legalization Effects & Bioassays 🏥
On reasons for first using cannabis, a population survey found people using it for self-medication had a higher average THC levels as well as increased anxiety, depression & paranoia
Are reasons for first using cannabis associated with subsequent cannabis consumption (standard THC units) and psychopathology?
https://pubmed.ncbi.nlm.nih.gov/40858508/
In Spanish users of cannabis & tobacco, the majority experienced withdrawal when stopping cannabis, with higher severity in women
Consumption patterns and withdrawal symptoms in dual cannabis-tobacco users in Spain: Cross-sectional study
https://www.sciencedirect.com/science/article/pii/S2352853225000744
On cannabinoid use among adult women, a review of 270 studies found the majority related to safety, ~15% on motivations for use & 10% on perceptions
Cannabinoid Use Among Adult Women: A Scoping Review
https://journals.sagepub.com/doi/pdf/10.1177/15409996251385404
In older adults with a cannabis prescription, a Canadian analysis found that drug interactions may not be adequately considered
Concomitant use of medical cannabis and drugs associated with risks of interaction in older patients: a longitudinal cohort study
https://academic.oup.com/ageing/article/54/12/afaf359/8380187
For older adults with serious falls, cannabinoids were the drug least associated with falls
Relationship of Ethanol, Cannabinoids, Benzodiazepines, and Opioids to Serious Injuries from Falls in Adults Aged 55 and older
https://www.sciencedirect.com/science/article/abs/pii/S0736467925004639
For CBD & child safety, the survey found that people CBD products in the house are more likely to believe that CBD was safe for adults & children, non-addictive & non-fatal at high doses (all of which is true & and I don’t quite get the worries of these researchers)
Parent and Caregiver Perceptions of Cannabidiol Products May Put Children at Risk for Unintentional Exposure
https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2025.1714993/abstract
For the prevalence of medical cannabis in pediatrics, this thesis project surveyed parents at the British Columbia Children’s Hospital
Prevalence, practices, and attitudes of medicinal cannabis use in pediatrics
https://open.library.ubc.ca/soa/cIRcle/collections/ubctheses/24/items/1.0449906
On a medical cannabis app called Smart Cannabis
Smart Cannabis: A Prescription Digital Therapeutic Framework for Enhancing Medical Cannabis Care
https://www.sciencedirect.com/science/article/abs/pii/S0149291825004126
On identifying HHC analogs in urine
In Vitro Metabolic Profiling of 18 Semi-Synthetic Cannabinoids—Hexahydrocannabinol (HHC) and Its Analogs—with Identification in an Authentic Hexahydrocannabiphorol (HHCP) Urine Sample
https://academic.oup.com/clinchem/article-abstract/71/11/1158/8226013
When giving rats cannabis in experiments, an exploratory trial of using oromucosal/buccal administration
Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
https://app.jove.com/t/68104/oromucosal-as-an-alternative-method-for-administration-cannabis
🧒 Adolescents & Young Adults 🧒
In young adults with ADHD, they had different outcomes from cannabis use depending on their levels of inattentive (IN) versus hyperactive/impulsive (HI) symptoms
Understanding the Relationships between ADHD Symptoms and Cannabis-Related Consequences among Young Adults
https://pubmed.ncbi.nlm.nih.gov/41278425/
“IN symptoms were directly associated with cannabis-related occupational/academic consequences, self-care consequences, and blackouts/memory impairment, independent of quantity of cannabis consumption. HI symptoms showed positive indirect associations with physical dependence, impaired control, and CUD [cannabis use disorder] through greater amount of cannabis used. Conversely, IN symptoms had negative indirect associations with these outcomes, mediated by amount of cannabis used.”
For adolescent cannabis use & cognition, public health data found cannabis use linked to reduced attention & declarative memory at age 24, especially among almost daily/daily users
A Fine-Grained Longitudinal Study of Adolescent Cannabis Use and Its Relation to Cognitive Performance in Young Adulthood
https://link.springer.com/article/10.1007/s11469-025-01604-0
In adolescent trends on perceived substance harmfulness, tobacco & alcohol harmfulness perception increased while cannabis perceptions remain stable or decreased
Trends in perceived harmfulness of tobacco, alcohol, and cannabis and its’ use in 12–16-year-olds, from 2003 to 2023
https://www.sciencedirect.com/science/article/pii/S0376871625004661
In young adults in Los Angeles, on the effects of changes in cannabis policy
Controlled Use of Cannabis Among Young Adults in Los Angeles Across Changes in Cannabis Policies
https://link.springer.com/article/10.1007/s11469-025-01608-w
In young adults of New York City vaping cannabis, an analysis of their characteristics
Cannabis products and trends in a cohort of young adults: The VapeScan longitudinal study
https://pubmed.ncbi.nlm.nih.gov/41409445/
Among adolescents living on the Cherokee reservation, the strongest protective effects on cannabis use were parental support, teacher support & community adult support
Under the Influence of Norms: Social Support and the Use of Alcohol and Cannabis Among Reservation-Based Adolescents
https://journals.sagepub.com/doi/pdf/10.1177/0044118X251399829
In French Polynesia, evaluating the Kusa program for reducing adolescent cannabis consumption
Impact of the Kusa prevention program on cannabis consumption and emotional competencies among French Polynesian adolescents
https://journals.sagepub.com/doi/full/10.1177/17579759251317515
🧠 The Brain & Neurological Disorders 🧠
For the cognitive effects of cannabis use, a review across the lifespan
Cognitive Effects of Cannabis Use Across the Lifespan: A Review for Clinical Practice
https://journals.lww.com/jan/abstract/2025/10000/cognitive_effects_of_cannabis_use_across_the.2.aspx
For neurocognitive disorders, a book chapter on using the cannabinoids
Phytocannabinoids for Neurocognitive Disorders
https://www.taylorfrancis.com/chapters/edit/10.1201/b22854-26/phytocannabinoids-neurocognitive-disorders-genevieve-steiner-lim-madilyn-coles-najwa-joelle-metri-ava-murali-caitlin-dooley-zainab-al-modhefer-jackson-mcpartland-ali-butt-rose-chesworth-tim-karl
In a mouse model of Huntington’s disease, restoring CB1 receptor function in the GABA neurons of their hippocampus (memory center of the brain) rescued memory deficits
Restoration of CB1 receptor function in hippocampal GABAergic neurons rescues memory deficits in Huntington’s disease models
https://link.springer.com/article/10.1186/s40035-025-00500-w
In a rat model of Alzheimer’s disease, activating the CB1 receptor prevented cognitive & social deficits via the CB1 receptor & modulation of inflammation
Cannabidiol prevents cognitive and social deficits in a male rat model of Alzheimer’s disease through CB1 activation and inflammation modulation
https://www.nature.com/articles/s41386-025-02213-0
In a mouse model of Alzheimer’s disease, silencing the enzyme MAGL (which breaks down 2-AG) in their astrocytes (the most predominant brain support cell) caused reduced alpha-beta plaque pathology, neurodegeneration & neuroinflammation
Selective Inactivation of Astrocytic Monoacylglycerol Lipase for Alzheimer’s Disease Therapy
https://pubmed.ncbi.nlm.nih.gov/41427297/
In mouse models of Alzheimer’s disease, the differences in levels of the CB1 receptor, FAAH enzyme (which breaks down anandamide) & MAGL enzyme (which breaks down 2-AG) versus humans that might be limiting clinical translation
Differences in the co-distribution of the Cannabinoid Receptor-1, FAAH, and MAGL in the human and mouse brain could be limiting clinical translation of endocannabinoid outcomes in mouse models of Alzheimer disease
https://www.biorxiv.org/content/biorxiv/early/2025/12/12/2025.12.10.693257.full.pdf
In a brain tissue model of Alzheimer’s disease with joined receptor complexes of CD1 & NMDA (activated by glutamate), the neurotoxicity from NMDA receptor activation was offset by the neuroprotective effects of CB1 receptor activation
Cannabinoid CB1 Receptor Activation Mitigates N-Methyl-d-aspartate Receptor-Mediated Neurotoxicity
https://pubs.acs.org/doi/full/10.1021/acsptsci.5c00230
In young zebrafish (a common model of organism of development), activating the CB1 receptor led to neural problems in myelination (the myelin covering the axons allowing them to transmit their messages)
Activation of cannabinoid receptor CB1 leads to aberrant myelination in development
https://www.biorxiv.org/content/biorxiv/early/2025/12/11/2025.12.10.693544.full.pdf
In a novel device for stimulating brain slices, tests on the calcium flux effects of CBD & anandamide
Bubble Perfusion Brain Slice Culture with Single-Droplet Stimulus Delivery in a 3D Printed Microfluidic Device
https://pubs.acs.org/doi/full/10.1021/acsmeasuresciau.5c00028
💭 Mental Health, Addiction & Cannabis Use Disorder 💭
For cannabis use motives & cannabis-related problems, male participants had a stronger association than females
Sex Differences in the Association Between Cannabis Use Motives and Cannabis-Related Problems
https://www.tandfonline.com/doi/abs/10.1080/02791072.2025.2603332
In an analysis of treatments for cannabis use disorder, self-reporting of cannabis use generally aligned to the urinary bioanalysis
Detecting cannabis use reduction through biochemical verification of urinary cannabinoids: An aggregated analysis of cannabis use disorder treatment trials examining average reductions and individual cut-points
https://pubmed.ncbi.nlm.nih.gov/41408987/
For harm reduction with cannabis edibles, a thesis project on protective behaviors in an online cannabis community
Understanding the health perceptions and protective behavioral factors for cannabis edibles in an online community of cannabis users
https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/n009wb31f
For the expected relief from alcohol & cannabis use, a survey found that the pleasure increased the relief
Perceptions of negative reinforcement in the natural environment: Characterizing subjective alcohol- and cannabis-contingent relief
https://www.sciencedirect.com/science/article/abs/pii/S0306460325003594
For predicting substance use disorder transitions in people with cannabis & stimulant use, a comparison of models found income & demographics to contribute substantially to prediction
Comparing random forest and elastic net models to predict substance use disorder transitions in participants with cannabis and stimulant use: Evidence from the All of Us cohort
https://www.sciencedirect.com/science/article/pii/S037687162500465X
For ADHD & alcohol/cannabis use, an analysis across ethnicity & gender
Reevaluating the link between psychopathology symptoms and alcohol and cannabis use: An examination across intersectional race/ethnicity and gender identities
https://psycnet.apa.org/record/2026-85086-011
In a rat model of autism, activating their CB1 & CB2 receptors lessened behavioral abnormalities & rectified dysregulation of the lipids in their hippocampus (memory center of the brain)
Cannabinoid Receptors CB1 and CB2 Activation Restores Hippocampal Lipid Profiles and Alleviates Autism‐Like Behaviors in Valproic Acid‐Induced ASD Rats
https://onlinelibrary.wiley.com/doi/pdf/10.1111/cns.70591
🦠 The Immune System & Microbial 🦠
For the antimicrobial properties of cannabis seeds, on the effects of 2 different extraction methods
Phenolic Constituents Drive Antimicrobial and Antibiotic-Enhancing Activities of Cannabis sativa Seed Extracts Obtained by Two Extraction Methods
https://www.mdpi.com/2223-7747/15/1/27
🦴 Pain, Musculoskeletal & Surgeries 🦴
After surgery for a long bone fracture, cannabis users tended to use more opioids
Effect of Cannabis Use on Postoperative Opiate Requirements After Long Bone Fracture
https://www.sciencedirect.com/science/article/pii/S2773157X25003133
In people with neuropathic pain, cannabis yielded a high clinical response rate & the psychological stress improvements were captured via the biomarker of ultra-weak photon emission
Ultra-Weak Photon Emission Demonstrates Specificity for Anxiety over Pain in Cannabis-Treated Chronic Neuropathic Pain: A Biomarker Validation Study
https://www.mdpi.com/2306-5354/12/12/1359
In people with traumatic acute lower back pain, the combination of PEA & the amino acid acetyl-L-carnitine caused significant reductions in neuropathic pain & reduced consumption of NSAIDs
Unlocking Relief: Investigating the Impact of a Fixed Combination of Acetyl‐L‐Carnitine and Palmitoylethanolamide on Traumatic Acute Low Back Pain
https://onlinelibrary.wiley.com/doi/pdf/10.1111/ene.70334
In aging male mice, destroying the CB1 receptors in their hypothalamus (body control center) reduced the frailty of their joints via reduced levels of corticosterone & increased mineralization
Ablation of hypothalamic Cnr1 leads to reduced meniscal mineral volume and articular cartilage damage in aging male mice
https://www.sciencedirect.com/science/article/pii/S1063458425011161
For painkilling, CBD lipid nanocarriers
Cannabidiol-based lipid nanocarriers with analgesic activity
https://www.nature.com/articles/s41598-025-33238-6_reference.pdf
❤️ The Heart & Blood ❤️
For the albumin in blood, an analysis of its binding interactions with 6 cannabinoids (THC, CBD, CBC, CBG, THCV & CBDV) found that all but CBDV & CBG had only minimal or stabilizing effects on its structure
Insights into cannabinoid-HSA interactions: spectroscopic analysis and molecular docking for binding site characterization
https://www.tandfonline.com/doi/full/10.1080/07391102.2025.2551174
🎗️ Cancer & Chemotherapy 🎗️
When treating non-Hodgkin’s lymphoma, the traditional chemotherapy drug effects are enhanced by anandamide, CBD & the CB1 agonist WIN-55 212 22
Cytotoxicity of Cannabinoids in Combination with Traditional Lymphoma Chemotherapeutic Drugs Against Non-Hodgkin’s Lymphoma
https://www.mdpi.com/2227-9059/14/1/3
For triple-negative breast cancer, a case report on the benefits of CBD, melatonin & oxygen-ozone therapy
Integrative Use of Cannabidiol, Melatonin, and Oxygen-Ozone Therapy in Triple-Negative Breast Cancer with Lung and Mediastinal Metastases: A Case Report
https://www.preprints.org/manuscript/202512.1919
For colon cancer, on creating a micelle delivery system for CBD
Development and In vitro kinetic evaluation of PEG-chitosan biohybrid micelles loading CBD with bile acid/quercetin as surface modifiers for colon cancer therapy
https://www.sciencedirect.com/science/article/abs/pii/S0003986125004254
💊 Synthetic Cannabinoids & Hemp-Derived Cannabinoids 💊
For the synthetic cannabinoids, on creating a novel risk score for their harm
Development of a novel risk score reflecting the relative harm potential of synthetic cannabinoids based on prevalence estimates, well-documented intoxication cases and basic pharmacological data
https://pubmed.ncbi.nlm.nih.gov/41423817/
When combusting synthetic cannabinoids, on the neurotoxic effects of their breakdown materials
Neurotoxic potential of synthetic cannabinoids’ pyrolysis products
https://www.sciencedirect.com/science/article/pii/S0300483X25003336
For 28 synthetic cannabinoids, an analysis of their activity at the CB1 & CB2 receptors
In vitro pharmacological activity of twenty-eight synthetic cannabinoid receptor agonists at the type 1 and 2 cannabinoid receptors
https://www.sciencedirect.com/science/article/pii/S0197018625001123
🔬 Biochemical Discoveries & Research Tools 🔬
For synthesizing cannabinoids, on recent advances in using mental reagents
Recent Advances in Organometallic Reagents and Catalysts: A Concise Strategy to Synthesize Cannabinoid Natural Products
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.202503660
On using the algae Chlamydomonas reinhardtii to produce cannabinoids
Insights into cannabinoid biosynthesis in Chlamydomonas reinhardtii : successes with NphB and limitations of CBDAS expression
https://www.biorxiv.org/content/biorxiv/early/2025/12/10/2025.12.09.693288.full.pdf
In cell cultures of fetal bovine versus calf serums, they differ in their endocannabinoid contents
Fetal Bovine and Calf Serums Differ in Their Contents of Endocannabinoids, Unsaturated Fatty Acids, Monoacyl-Glycerols, N-Acyl-Ethanolamines, Oxylipins and Cytokines
https://www.biorxiv.org/content/10.64898/2025.12.15.694409v1
Thanks.
- lex
PS: For this week’s Texas blues, the 1927 album ‘Presenting Henry Thomas’. An itinerant street musician also known as Ragtime Texas, Thomas is widely viewed as the earliest Black folk artist of the US to produce a significant body of recordings. His 24 songs bridged the 19th & 20th centuries with their mix of spiritual ballads, reels, dance songs & blues. As you can hear on the first track, he would also sometimes simultaneously play the pan pipes (you’ll recognize the hook from “Going up the Country” by Canned Heat, which they blew up at Woodstock). Though he returned to obscurity in the ‘30s with nothing known of his later life, the music of Henry Thomas was a key part of the folk music revival of the early 1960s. Harry Smith included two of Thomas’ songs on his legendary 1952 ‘Anthology Of American Folk Music’, leading to covers by Bob Dylan, the Lovin’ Spoonful, Taj Mahal, the Nitty Gritty Dirt Band & the Grateful Dead.
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