C&P#173: for autism, endometriosis, COVID’s smell loss & Gulf War Illness
Grenada decrims & expunges!
Cannabinoids & The People,
or; Drugs & Drug Wars
(buy my canna-graphic novels based on ‘Moby Dick, or; The Whale’ & proceeds go to Americans for Safe Access to support medical cannabis patients)
🌟 This week 🌟
CBD for children’s autism & women’s endometriosis
On CHS, NIDA says ~67k cases in last 7 years
Cannabis for cancer symptoms
On double-edged sword of bone repair & cannabinoids
Oleoylethanolamide for Gulf War Illness
PEA for olfactory problems of COVID
More hair loss in cannabis users? (especially the females)
Cannabis & impaired motor learning
Preclinical: cannabinoids for ALS + PEA for Alzheimer’s + cannflavin for autism + CBD for reduced HIV infection + THC for chemo weight loss
Avoidant attachment styles for the win! (of buffering cannabis use linked to depression)
Even cannabis fungus is anti-inflammatory!
PEA for your cat & dog’s joint pain
Harm reduction: recent drop in overdose deaths is slowing down
Does the Stoned Ape theory live?
(this week’s numbers: ~9,500 words, ~24 minutes reading time, 203 papers)
Hello everyone,
Welcome to the 173rd edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news as well as coverage of other psychoactives, the War on Drugs & harm reduction. Support this work with a paid subscription or by buying me a coffee.
For producing cannabinoid content, work with my company White Whale Creations: writing, science archives, social media, newsletters & podcasts (especially podcasts).
As always, ask me anything!
📌 Editor’s note 📌:
This week, a new record for the number of canna-science articles to come out in one day: 59 papers
(you can see why I get behind sometimes)
🤝 Sponsor 🤝: ICBC 2026 half-off ticket giveaway!
For ICBC 2026 in Berlin, today is the last day to enter the contest for one of the two 50% off tickets. Just follow any of their social media channels or their newsletter below & let me know. Winners will be notified first thing tomorrow morning.
And for everyone else, the last day of early bird tickets is Wednesday (Jan 28th). Act now to get a great price on a great conference.
With 5k+ people from 80+ countries, I’m looking forward to this year’s conference because, as a canna-writer, it’s one of the best places for networking I’ve found since moving to Europe. Save an extra 25% off with my coupon code: WhiteWhale25
https://internationalcbc.com/register/
Follow ICBC on social media for canna-EU updates:
🎥 Lex’s new work 🎤
@CannabinoidsAndThe People vids sponsored by CHRI & the National Cannabis Study:
The delta THCs & THC Acid (and my new recording spot, which TikTok liked so much that it showed this video to 6 people total)
Canna-Edu Vids for CV Sciences:
(on YT @CVSciencesInc & on TT @pluscbd)
My 📚 Vids:
(@LexPelgerAndHisBooks on TikTok, YouTube & Instagram)
(none this week. check out the back catalog)
And as always, at the bottom is the album of the week: the West Coast blues of Jimmy McCracklin
🧰 Free resources 🧰
CVResearch.info: the cannabinoid science archive I maintain for CV Sciences
My glossary of cannabinoid terms (& containing the legend for my Neural Ocean metaphor with endocannabinoid whales)
Roundup of fav newsletters:
#Canna: Marijuana Moment, Cannabis Law Report, Cultivated, Cannabis Musings (oy vey), Talking Joints Memo, Sticky Bits, Highly Objective, Cannabitch, Indigenous Cannabis Industry Association, Policy, Decoded, Dr. Peter Grinspoon, Doctor Approved, Medical Marijuana Memory Blog (by Dame Alice O’Leary Randall)
#DrugWar: InSight Crime, Marshall Project, Students for Sensible Drug Policy
#HarmReduction: Filter, Drug Data Decoded, International Drug Policy Consortium, National Harm Reduction Coalition, Canadian Drug Policy Coalition
#Psychoactives: Psychedelic Alpha, Ecstatic Integration, ICEERS, Substance, The Microdose
💖 Ways to support this work 💖
Venmo: @Lex-Pelger
PayPal: donate here
📣 A request to spread the word 📣
This newsletter only spreads by word of mouth, so please forward to friends & colleagues.
🍃 BEST OF CANNABINOID SCIENCE 🍃
(most of the phytocannabinoid data is here & most of the ECS data is in the ‘Canna-Science Archive’ at the bottom)
⚕️ Clinical ⚕️
In children with autism, CBD-rich cannabis significantly improved “anxious-shyness, perfectionism, ADHD index, emotional lability, and hyperactivity-impulsivity” with trends towards improvement in oppositional behavior, cognitive inattention, hyperactivity & inattention scores
CBD-Rich Cannabis Therapy in Children with Autism Spectrum Disorder May Improve Symptoms of Hyperactivity and Attention Deficit: An Open-Label Study
https://www.benthamdirect.com/content/journals/cn/10.2174/011570159X390368251014072051
In women who had surgery for their endometriosis uses, 10 weeks of CBD oil reduced pain & improved psychological symptoms & quality of life measures
Cannabidiol-Enriched Extract Oil for Postoperative Management of Chronic Pelvic Pain Secondary to Endometriosis: A Randomized Clinical Trial—DREAMLAND Study
https://journals.sagepub.com/doi/full/10.1177/25785125251413989
In people with newly diagnosed advanced pancreatic cancer, cannabis substantially improved insomnia, pain & appetite loss
Pilot Randomized Trial of Medical Cannabis to Reduce Symptom Burden in Patients With Newly Diagnosed Advanced Pancreatic Cancer (CanPan)
https://ascopubs.org/doi/pdfdirect/10.1200/OP-25-01165
And in Maine cancer healthcare providers, a survey about cannabis found the majority agreed it can be effective for managing symptoms
Survey of MaineHealth Cancer Care Network Providers on Cannabis Use: Preparation for Studies Sponsored by the National Cancer Institute
https://knowledgeconnection.mainehealth.org/jmmc/vol8/iss1/13
For depression, the UK Medical Cannabis Registry found that the initiation of cannabis-based medicinal products to be associated with improvements in severe anxiety & depression severity
UK Medical Cannabis Registry: A two-year case series of clinical outcomes in depression
https://www.sciencedirect.com/science/article/pii/S0165032725025728
For cannabis & health-related quality of life, data from the UK Medical Cannabis Registry found over 70% experienced improvements to health quality & 50+% had clinically significant improvements on anxiety & sleep scores
Clinical Outcomes and Patient Profiles in the UK Medical Cannabis Registry: A k-Means Clustering Analysis
https://pubmed.ncbi.nlm.nih.gov/41510842/
In veterans with Gulf War Illness, 10 weeks of 400 mg of oleoylethanolamide (the endocannabinoid of satiation) reduced fatigue & improved mood disturbance scores with participants reporting increased energy, emotional well-being & social functioning
Oleoylethanolamide supplementation improves mood and reduces fatigue in veterans with GWI in a 15-week randomized, double-blind, placebo-controlled exploratory clinical trial
https://www.nature.com/articles/s41598-026-35168-3
In people with olfactory dysfunction from COVID, a meta-analysis of PEA & luteolin (a flavonoid commonly paired with PEA) found significant improvements in olfactory scores
P-1648. Efficacy of Co-Ultramicronized Palmitoylethanolamide With Luteolin for Managing Post-COVID-19 Persistent Olfactory Dysfunction: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
https://pmc.ncbi.nlm.nih.gov/articles/PMC12792500/
For restless leg syndrome, a case report of treating it with PEA
Palmitoylethanolamide (PEA) in the treatment of restless legs syndrome: Rationale and case report
https://link.springer.com/article/10.1007/s10072-025-08677-8
For adults substituting cannabis beverages for alcohol, a survey on their reduction of alcohol-related harms
The Exploration of Cannabis Beverage Substitution for Alcohol: A Novel Harm Reduction Strategy
https://www.tandfonline.com/doi/abs/10.1080/02791072.2026.2614506
In public health data in middle-aged people, cannabis users had lower blood levels of Klotho (a biomarker of aging & metabolic health)
Association between cannabis consumption and serum Klotho levels in middle-aged U.S. adults: NHANES cross-sectional analysis
https://link.springer.com/article/10.1186/s42238-025-00380-x
But in US adult cannabis users, they had significantly accelerated aging, perhaps because of higher levels of blood cadmium
Current marijuana use is cross-sectionally associated with accelerated biological aging among U.S. adults: exploring mediating effect of blood cadmium
https://www.sciencedirect.com/science/article/pii/S1279770726000096
In healthy occasional cannabis users, only in females did CBD decrease the blood levels of the endocannabinoids PEA & oleoylethanolamine
Sex-specific association between low oral doses of cannabidiol (CBD) and plasma concentration of anandamide (AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA) in healthy occasional cannabis users
https://link.springer.com/article/10.1186/s42238-025-00356-x
For attachment styles & cannabis use, attachment anxiety strengthened the link between cannabis use & depression, while avoidance attachment style buffered this link to depression, with the increases in depression were strongest for those who were both anxious & avoidant
Problematic cannabis use and attachment insecurities as Joint predictors of Depression: Cross-Sectional and longitudinal models
https://www.sciencedirect.com/science/article/abs/pii/S0306460326000110
My therapist wife is going to have a field day with this one related to her avoidant husband.
In dogs & cats with joint pain, 6 weeks of PEA caused significant improvements in multiple pain domains, with more help for dogs
Levagen+ (Palmitoylethanolamide) alleviates joint pain and reduces the impact of joint pain in canines and felines: A Double-Blind, Placebo-Controlled, Randomised Clinical Trial
https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1703143/abstract
In canine drug-resistant epilepsy, a case report of a dog named Jack using CBD
Cannabidiol in Canine Drug-Resistant Epilepsy. A Comprehensive Case Study of Jack’s Journey
https://assets-eu.researchsquare.com/files/rs-8523955/v1_covered_e74d4f2e-1efa-4ce4-9de9-d64446be614e.pdf
In dogs with anxiety, CBD had no significant treatment effects
The perception of pet owners on their dog’s anxiety while supplemented with cannabidiol in a double-blinded randomized placebo-controlled cross-over clinical trial
https://www.sciencedirect.com/science/article/abs/pii/S1558787825001303
📑 Reviews 📑
On CBD & status epilepticus (seizures of 5+ minutes), a review of 11 papers
Cannabidiol in the treatment of status epilepticus
https://www.aimspress.com/aimspress-data/aimsmeds/2025/4/PDF/medsci-12-04-025.pdf
Abd for complex epilepsies & CBD, a review of 57 studies on reduced seizures, prolonged seizure freedom & mild adverse events & drug interactions
A systematic review of highly purified cannabidiol in developmental and epileptic encephalopathies and complex treatment-resistant epilepsies: Changes in seizure frequency and adverse events
https://www.sciencedirect.com/science/article/abs/pii/S092012112600001X
And for CBD & epilepsy, a review on the effects on neuroinflammation
Epilepsy, neuroinflammation and cannabidiol What do we know thus far?
https://www.proquest.com/openview/604ded678429d6aa28572edaca984722/1
And on creating a new protocol for CBD & treating rare epilepsies, surveys & interviews on priorities
PAtient-Centric epilepsy clinical trIal model For Improved health outcomes using Cannabidiol (PACIFIC study)—a methodology for developing patient-centred clinical trials in rare epilepsy syndromes
https://link.springer.com/article/10.1186/s12874-025-02757-1
“Four priorities emerged: (1) decentralised trial models to improve access and inclusion, particularly through home-based care; (2) embedding cultural safety and systems integration to support diversity; (3) prioritising outcomes beyond seizure reduction, including quality of life and patient-reported measures; and (4) improving communication and accessibility through digital innovation.”
In people who had orthopedic surgery, this review of 100 studies found CBD enhancing fracture repair while cannabis was linked to impaired bone healing, higher postoperative pain scores & greater opioid consumption
Cannabis Use in Orthopaedic Surgery: Effects on Fracture Healing, Opioid Requirements, and Clinical Outcomes
https://assets.cureus.com/uploads/review_article/pdf/446288/20260106-111086-s85amo.pdf
And in a rat model of postmenopausal osteoporosis, CBD did not alter bone metabolism or mitigate bone loss
Long-term cannabidiol treatment did not restore bone microstructural defects in skeletally mature ovariectomized Sprague-Dawley rats
https://academic.oup.com/jbmrplus/advance-article/doi/10.1093/jbmrpl/ziaf197/8415531
For neurodegenerative diseases, a review on the potential benefits of the cannabinoid, terpenes & flavonoids
Therapeutic Applications of Secondary Metabolites From Cannabis Sativa in Neurodegenerative Diseases
https://www.igi-global.com/chapter/therapeutic-applications-of-secondary-metabolites-from-cannabis-sativa-in-neurodegenerative-diseases/399571
For the acidic cannabinoids, a review on their therapeutic potential
Therapeutic potential of acidic cannabinoids: an update
https://link.springer.com/article/10.1186/s42238-026-00387-y
For viruses causing neuroinflammation, a review on THC as a double-edged sword
Delta9-Tetrahydrocannabinol: A blunt weapon or a double-edged sword for virus-induced neuroinflammation
https://pubmed.ncbi.nlm.nih.gov/41495623/
For liver diseases, a review of the terpene beta-caryophyllene
Pharmacological, Molecular Mechanisms, and Therapeutic Potential of β‐Caryophyllene and β‐Caryophyllene‐Rich Plants in Liver Diseases
https://faseb.onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.202502436R
For the synthetic PEA analog Adelmidrol, a review for its therapeutic effects across an array of conditions
Therapeutic potential, pharmacological role and molecular mechanisms of Adelmidrol, an analogue of palmitoylethanolamide
https://www.sciencedirect.com/science/article/pii/S2590257126000015
⚠️ Harms ⚠️
In the US & Canada, an analysis of the public health impact of legalizing adult-use cannabis by 2 honest curmudgeons (Hall & Fischer, who I always appreciate for pointing out the cannabis/cancer risk hidden in the public health data)
Public health impacts of legalizing recreational cannabis use in Canada and the US
https://pmc.ncbi.nlm.nih.gov/articles/PMC12805063/
For cannabinoid hyperemesis syndrome, an analysis from NIDA found ~62k cases between 2017 & 2024
Cannabinoid Hyperemesis Syndrome: Unveiling the National Impact on Youth
https://publications.aap.org/pediatricsopenscience/article/doi/10.1542/pedsos.2025-000976/206083
In people with cannabis use disorder, 12 weeks of cognitive behavioral & motivational enhancement group therapy reduced their cannabis use & psychiatric symptoms
Effectiveness and clinical predictors of a virtual based combined cognitive behavioral and motivational enhancement group therapy for adults with cannabis use disorder
https://www.sciencedirect.com/science/article/pii/S0376871626000293
And for harmful cannabis use, a meta-analysis of 9 trials found that cognitive behavioral therapy did not produce significant reductions in any of the measurements
Effectiveness of Cognitive Behavioral Therapy for harmful cannabis use: A Systematic Review and Meta-Analysis
https://keele-repository.worktribe.com/output/1551334
For cannabis & hair loss, this Monte Carlo analysis found higher cannabis exposure associated with increased hair loss severity & reduced follicular density, with larger effects in people assigned female at birth
Modeling Oxidative Stress-Linked Telogen Effluvium Using Monte Carlo Simulation of Published Trichoscopy Norms and Cannabis Exposure Distributions
https://assets.cureus.com/uploads/original_article/pdf/447485/20260116-238185-u3qf4n.pdf
In motor learning tests, cannabis use was associated with impaired implicit motor learning, potentially because of increased resting state neural oscillatory activity as well as the resulting increased cortical noise & reduced visuospatial short-term & working memory
Longer chronic cannabis use in humans is associated with impaired implicit motor learning and supranormal resting state cortical activity
https://pubmed.ncbi.nlm.nih.gov/41499355/
For cannabis & arrhythmias (irregular heartbeat), a meta-analysis of 21 studies found an association with arrhythmias in cannabis users, but a protective effect among people with heart disease
The Highs And Hearts: A Systematic Review And Meta-analysis On The Use Of Cannabis And Arrhythmias
https://www.sciencedirect.com/science/article/abs/pii/S1071916425008735
And for heart failure & cannabis use, public health data found an association with increased 30-day readmission rates
The Emerging Impact Of Marijuana Use On Heart Failure Outcomes: A Nationwide Analysis
https://www.sciencedirect.com/science/article/abs/pii/S1071916425007869
In people with anxiety sensitivity, they were more likely to have cannabis-related problems
Anxiety sensitivity and cannabis-related problems among Hispanic/Latine adults: The roles of sex and cannabis use motives
https://psycnet.apa.org/record/2027-15069-005
In older women, public health data found a potential association between cannabis smoking & subjective cognitive complaints
History of cannabis smoking and subjective cognitive complaints in older women
https://karger.com/ned/article-abstract/doi/10.1159/000550276/942419/History-of-cannabis-smoking-and-subjective
A case report of a cannabis-induced psychotic disorder with itchiness, hallucinations & delusions
Psychotic Risk Associated With Cannabinoid Use: A Case Report of Ekbom-Like Delusional Infestation
https://assets.cureus.com/uploads/case_report/pdf/446743/20260106-146673-s85amo.pdf
In a cancer patient, a case report of a fungal infection potentially due to their cannabis
P-1724. Cryptococcus neoformans var. grubii infection due to medical cannabis consumption
https://pmc.ncbi.nlm.nih.gov/articles/PMC12792723/
In a case report of diffuse alveolar hemorrhage, the doctor suggested it was from cannabis use associated with a viral respiratory infection
Cannabis-Induced Diffuse Alveolar Haemorrhage: A Case Report From the Intensive Care Unit
https://assets.cureus.com/uploads/case_report/pdf/447049/20260115-101493-u3qf4n.pdf
When vaping hemp-derived cannabinoids, a review of the toxicity & public health consequences
Toxicity and health effects of delta-8, delta-9, and delta-10-tetrahydrocannabinol and unregulated cannabinoids in vaping products
https://www.sciencedirect.com/science/article/pii/S2214750026000041
In a mouse model of prenatal CBD exposure, the male offspring had increased thermal pain sensitivity while the females had impaired cognition & reduced excitability of the prefrontal cortex
Oral Consumption of Cannabidiol During Pregnancy Alters Behavior in Mouse Offspring
https://journals.sagepub.com/doi/full/10.1177/25785125251413416
In rats doing cognitive tasks, high doses of CBG disrupted sustained attention in females but not males
High doses of orally administered cannabigerol produce deficits in sustained attention in female rats
https://www.sciencedirect.com/science/article/abs/pii/S0091305726000092
In a tissue model of the brain, the anti-inflammatory effects of CBG were inconsistent & could be genotoxic at high doses
Could cannabigerol protect against neuroinflammation? Insights from an in vitro microglial study
https://www.sciencedirect.com/science/article/pii/S0300483X26000132
🐁 Preclinical 🐁
In a rat model of cerebral vasospasm (intense constriction of brain arteries), CBD reduced severity & improved outcomes
The Effects of Cannabidiol on Vasospasm Induced by Subarachnoid Hemorrhage in Rats
https://link.springer.com/article/10.1007/s44411-025-00481-2
In a mouse model of weight loss from the chemotherapy treatment doxorubicin, THC reduced weight loss & increase the length of the small intestine
Delta-9-Tetrahydrocannabinol alleviates doxorubicin-induced weight loss but does not affect dextran sodium sulphate-induced colitis
https://link.springer.com/article/10.1186/s42238-026-00386-z
In a zebrafish model of amyotrophic lateral sclerosis, a novel cannabinoid formulation altered the transcription of 1576 genes “related to cytokine signaling, extracellular matrix organization, steroid metabolism, calcium-mediated signaling, and PI3K-Akt signaling, suggesting multi-target neuroprotective mechanisms”
Transcriptomic Analysis of a Cannabis-Derived Neuroprotective Therapy in a Zebrafish Model of ALS
https://storage.prod.researchhub.com/uploads/papers/users/79414/71b36b04-1e00-48ab-8ff7-1e1368df18d2/5-%20Transcriptomic%20Analysis%20of%20a%20Cannabis-Derived%20Neuroprotective%20Therapy%20in%20a%20Zebrafish%20Model%20of%20ALS.pdf
In a mouse model of HIV exposure, infection via their mucosal membranes was inhibited by CBD
Cannabidiol prevents mucosal HIV-1 transmission by targeting Langerhans cells, dendritic cells, macrophages and T-cells
https://www.biorxiv.org/content/biorxiv/early/2026/01/07/2026.01.07.697949.full.pdf
In a mouse model of Alzheimer’s disease, PEA lowered neurodegeneration via metabolism of the neurons & astrocytes (the brain’s most common support cell)
Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of Alzheimer’s disease
https://www.sciencedirect.com/science/article/pii/S075333222501159X
In a rat model of autism, the flavonoid cannflavin B lowered most of the behavioral & neuronal alterations
Cannflavin B ameliorates behavioural and neuronal systems alterations in adolescent rats exposed to prenatal valproic acid
https://www.sciencedirect.com/science/article/pii/S0753332225011436
In aging mice with cardiac hypertrophy (thickening of the heart), hemp seed fiber reduced heart thickness, lowered heart cell death & improved gut microbiome production of short-chain fatty acids
Hemp seed fiber supplementation alleviates myocardial hypertrophy in aging mice through activation of mitophagy
https://www.sciencedirect.com/science/article/pii/S175646462600006X
In the spleens of rats, chronic CBD decreased the number of lymphocytes (immune cells including T cells, B cells & natural killer cells)
Repeated administration of cannabidiol decreases splenic lymphocyte subset numbers in rats
https://journals.sagepub.com/doi/full/10.1177/03946320251411441
For the pregnane X receptor (a key regulator of drug metabolism), on the effects of THC, CBD & CBN in different species
Species differences in pregnane X receptor activation by Δ-9-tetrahydrocannabinol, cannabidiol, and cannabinol
https://www.sciencedirect.com/science/article/pii/S0006291X26000136
In salmonella bacteria & CBD, a computer analysis found its antibiotic effects may be through interactions with critical outer membrane proteins
P-1533. In silico Exploration of Cannabidiol Interactions with Outer Membrane Proteins in Salmonella Typhimurium LT2
https://pmc.ncbi.nlm.nih.gov/articles/PMC12792032/
🆕 Novel Studies 🆕
(a grab bag section for cool & new stuff)
In manga, an analysis of substance use depiction found 30% of the 500 chapters showed substance use, mostly tobacco
Substance use depictions in top-selling Shōnen and Seinen manga
https://www.tandfonline.com/doi/abs/10.1080/15332640.2026.2613285
As a papa with a little one getting into manga, I can’t say I remember seeing any drug use depicted yet. But I’ll let you know!
For the fungi that lives on cannabis, an analysis of its antioxidant & antibacterial activities
Evaluation of the antibacterial and antioxidant potential of the endophytic fungus EFY14 from Cannabis sativa L. leaves through metabolomics and molecular docking
https://www.tandfonline.com/doi/abs/10.1080/14786419.2025.2609961
From cannabis seeds, 5 new amides with anti-inflammatory activity
Five new phenylpropanoid amides from the seeds of Cannabis sativa L. and their anti-inflammatory activity
https://pubs.rsc.org/en/content/articlelanding/2026/nj/d5nj04080a/unauth
📰 US Headlines & Fav Articles 📰
An editorial about how medical patients & hemp farmers need more than just a delay in the looming federal hemp ban, by friend of the newsletter Sasha Kalcheff-Korn of Realm of Caring
https://www.marijuanamoment.net/hemp-farmers-and-patients-who-rely-on-cbd-need-more-than-just-a-delay-in-the-looming-federal-ban-op-ed/
Americans For Safe Access released a report on how the federal hemp ban will cut off medicine for millions of medical cannabis patients
https://www.safeaccessnow.org/state_call_to_action#gsc.tab=0
‘States Are Still Missing The Mark On Social Equity’
https://cannabisindustryjournal.com/news_article/states-are-still-missing-the-mark-on-social-equity/
For guns, the US Bureau of Alcohol, Tobacco, Firearms & Explosives (ATF) seeks to update their profile of a drug user from someone with any use in the past year to someone with “a pattern of unlawful use”
https://www.marijuanamoment.net/atf-moves-to-loosen-gun-ban-for-people-whove-used-marijuana-or-other-illegal-drugs/
Last year, the ATF denied ~9000 people for a gun permit because of drug use & almost half of those were based on a single use.
In New Jersey, sickle cell anemia added as a qualifying condition for medical cannabis
https://njbiz.com/nj-adds-sickle-cell-anemia-to-medicinal-cannabis-program/
This is a decision that should be left up to healthcare practitioners & not state public health bureaucrats.
In New Jersey, cannabis worker protections signed into law
https://www.businesswire.com/news/home/20260112238374/en/Governor-Murphy-Signs-Landmark-Cannabis-Worker-Protections-into-Law
In West Virginia, the state still hasn’t use the $34 million it made from its medical cannabis program
https://mountainstatespotlight.org/2026/01/19/medical-cannabis-money-still-sitting/
I’m always confused when I see states not spend millions of dollars. But also, I’m always angered when I see this huge amount of cash being taken out of the pockets of medical cannabis patients. I don’t have many hills that I will die on, but one of them is that medical cannabis should be untaxed.
In the top US & Germany hip-hop/rap music videos, unsurprisingly, over 40% depict cannabis or nicotine
Depictions of Nicotine and Cannabis in Popular US and German Hip-Hop/Rap Music Videos: A YouTube Top 100 Content Analysis
https://www.tandfonline.com/doi/full/10.1080/10826084.2025.2611414
🌐 International Updates 🌐
In Grenada, the legislature decriminalized cannabis for adults & automatically expunged criminal records & allowed for home cultivation for up to 4 plants
https://www.caribbeannationalweekly.com/news/grenada-decriminalises-cannabis-sets-age-of-21-for-legal-possession/
Here in France, first cannabis prescription unlikely this year
https://businessofcannabis.com/frances-first-prescriptions-unlikely-this-year-despite-complete-framework/
In the Netherlands, Bedrocan’s position as the exclusive supplier of medical cannabis is coming to an end as the government prepares a new supply model
https://www.newsweed.fr/fin-du-monopole-pour-bedrocan-aux-pays-bas/
In South Africa, on the underground cannabis social club scene & the threats to it by new government regulations
https://www.cannabiz-africa.com/blog/6968bd7d7669f0b88a3a5d17
Under the Bhutanese system of Gross National Happiness, on reevaluating their current ban of cannabis with a focus on societal well-being
THC Meets GNH: Considering Cannabis Policy in Bhutan through a Gross National Happiness Lens
https://scholarship.law.bu.edu/faculty_scholarship/4173/
In Indonesia, on the necessity to revise the narcotics laws to legally separate CBD from cannabis
MODIFICATION OF THE NARCOTICS LAW TO REGULATE CANNABIDIOL’S (CBD) MEDICAL USE
https://revista.domhelder.edu.br/index.php/veredas/article/view/3808
In Slovenia, an analysis on the perception & use of CBD by consumers
Slovenian Consumers’ Perceptions and Use of CBD Through the Lens of Motivation, Opportunity, and Ability Theory
https://www.ef.uni-lj.si/assets/Zaloznistvo/Raziskovalne-publikacije/Znanstvene-monografije/Slovenian-Consumers-Perceptions-and-Use-of-CBD.pdf
In the Philippines, this thesis interviewed stakeholders on medical cannabis regulation & accessibility
BEYOND THE LEAF: EXPLORING PERSPECTIVES ON MEDICAL CANNABIS REGULATION AND TREATMENT ACCESSIBILITY
https://cdn.epratrustpublishing.com/article/202511-01-024961.pdf
🚓 The War on Drugs 🚓
The DEA added 18 molecules to their definition of “cannabimimetic agents”
https://www.federalregister.gov/documents/2026/01/20/2026-00907/definition-of-cannabimimetic-agents-and-assignment-of-an-administration-controlled-substances-code
A report from the Congressional Research Service on the links between Chinese money laundering networks & illegal US cannabis grows
https://www.congress.gov/crs-product/R48786
A DEA agent was sentenced to 5 years for protecting childhood friends who were drug traffickers, among other accusations
https://apnews.com/article/dea-corruption-bongiovanni-sentence-28d916d9c83b73b21ff37c338f967eea
“Prosecutors said Bongiovanni’s corruption involved as much inaction as calculated coverup. They pointed to a turning point in 2008 when Bongiovanni could have acted on intelligence about traffickers he knew whose operation would evolve into a large-scale organization with links to California, Vancouver, and New York City.
He also was accused of authoring bogus DEA reports, stealing sensitive files, throwing off colleagues, outing confidential informants, covering for a sex-trafficking strip club and helping a high school English teacher keep his marijuana-growing side hustle. Prosecutors said he brazenly urged colleagues to spend less time investigating Italians and focus instead on Black and Hispanic people.”
In police recruits, a survey found there was more leniency towards cannabis & steroid use than other drugs
Assessing Police Recruit Disqualifiers: Public Attitudes Toward Drug Use, Mental Illness, Education, and Criminal Offending
https://link.springer.com/article/10.1007/s11896-025-09796-w
In Europe, first seizures of the synthetic opioids cychlorphine & methiodone
Multi-analytical identification of the synthetic opioids cychlorphine and methiodone (IC-26) in drug seizures: first detection in Europe
https://www.degruyterbrill.com/document/doi/10.1515/cclm-2025-1428/html
In the Maldives, they will begin to impose the death penalty for major drug trafficking
https://www.muslimnetwork.tv/maldives-to-impose-death-penalty-for-major-drug-trafficking/
In the hills of Assam, India, 300+ acres of illegal poppy fields destroyed
https://assamtribune.com/north-east/306-acres-of-illegal-poppy-fields-destroyed-in-manipur-hills-in-six-days-1604770
At the Mexican border, a book chapter on violence related to drugs & migration
Violence at Mexican Borders: Sovereignty, Drugs, and Migration
https://link.springer.com/chapter/10.1007/978-3-032-06412-7_5
For drugs produced in Afghanistan, Türkiye is a major transit route to Europe, according to Türkiye’s anti-narcotics police
https://www.afintl.com/en/202601090249
In the trafficking of synthetic opioids, interviews & analysis of network formation
Synthetic Opioid Trafficking Networks: Exploring Modern Drug Network Formation
https://www.tandfonline.com/doi/full/10.1080/01639625.2025.2608881
On darknet marketplaces, an analysis of their network formation
Oh, what an untangled web we weave: The abnormal structure of illegal digital marketplace communities
https://www.sciencedirect.com/science/article/abs/pii/S0148296326000238
On cocaine trafficking & the role of Brazil’s First Capital Command faction
Cooperation and Conflict: The case of mixed transnational cocaine trafficking operations linked to the First Capital Command (Primeiro Comando da Capital or PCC)
https://www.revista.ueg.br/index.php/atatot/en/article/view/17117
A history of France’s war on drugs
France’s War on Drugs: Contemporary Threats from Historical Perspectives
https://hal.science/hal-05430974/document
An analysis of the 1800s Chinese opium trade network
The Sassoon Empire and the Alchemy of Imperial Violence
https://d1wqtxts1xzle7.cloudfront.net/125819663/Opium_s_Ledger_The_Sassoon_Empire_and_the_Alchemy_of_Imperial_Violence_BP-libre.pdf
In the Netherlands, 3 tons of cannabis sweets & honey seized
https://cannabislaw.report/dutch-seize-three-tonnes-of-cannabis-sweets-and-honey-from-us/
At the Dublin airport, somebody filed a lost luggage report & then the €280k worth of cannabis was found in it
https://cannabislaw.report/dumb-americans-duo-charged-over-e348k-dublin-airport-cannabis-find-after-lost-luggage-report/
In Karachi, a hashish bust at the airport of Rs 30M (100k USD)
https://cannabislaw.report/bid-to-smuggle-hashish-worth-rs-30m-foiled-at-karachi-airport-fbr/
🚗 Driving 🚗
For cannabis-impaired driving, an analysis of health messages found that high levels of risk behavior detail increased the intentions to drive under the influence of cannabis
The Devil is in the Details: Exploring the Impact of Risk Behavior Detail (RBD) in Health Messages Targeting Cannabis-Impaired Driving
https://www.tandfonline.com/doi/pdf/10.1080/10410236.2025.2610730
⚖️ Business, Laws & Education ⚖️
In US states that legalized cannabis, smoking remained the most prevalent ingestion method but the likelihood of eating or drinking cannabis increased by ~35%
Increasing use of cannabis edibles in response to recreational cannabis legalization in the United States
https://www.sciencedirect.com/science/article/abs/pii/S0091743526000149
On the effects of cannabis legalization, public health found adult use cannabis legalization linked to increase cannabis use among groups with historically low levels of use
The Impact of Recreational Cannabis Legalization on Cannabis Use in U.S. Adults From 2016 to 2023: A Quasi-Experimental Study
https://www.sciencedirect.com/science/article/pii/S0749379725006890
The big banks are still refusing to work with cannabis businesses despite the coming reclassification of cannabis to Schedule III
https://www.cannabisculture.com/content/2026/01/18/big-banks-still-refusing-cannabis-despite-trump-marijuana-rescheduling/
Those cowardly toadies at Chase Bank closed my account of 20+ years just because I was making TikTok videos about cannabinoid science.
Leafy’s list of top 100 US dispensaries
https://www.leafly.com/news/leafly-list/top-100-us-dispensaries
On the role of cultural values in shaping national drug policy, an analysis of data from 25 countries using Hofstede’s cultural dimension scores
Drug policy and culture: A cross-national comparative study using Hofstede’s index
https://www.sciencedirect.com/science/article/abs/pii/S0955395925004281
In Brazil, an analysis of their anti-drug laws & suggestions for a decolonial approach to drug prohibition
International Criminal Antidrug Policies and Decoloniality: a critical assessment based on Brazilian experience
https://www.researchgate.net/publication/399616151_International_Criminal_Antidrug_Policies_and_Decoloniality_a_critical_assessment_based_on_Brazilian_experience
In a laboratory measurement of cannabis demand versus price, a comparison of the Hypothetical versus Actual Marijuana Purchase Task
Is toke cheap? Correspondence between cannabis demand and purchase in the laboratory
https://pubmed.ncbi.nlm.nih.gov/41521902/
🛡️ Harm Reduction News 🛡️
The recent drop in overdose deaths has slowed down, according to new CDC data
https://filtermag.org/cdc-overdose-death-data-decrease-slowing/
“Indiana’s needle exchanges are on the chopping block”
https://mirrorindy.org/indianapolis-safe-syringe-needle-exchange-senate-bill-91-michael-crider-harm-reduction-trump/
In Alberta, Canada, the public health data on overdoses are underreported because first responders often don’t want to mention opioids because, despite good Samaritan laws, that might trigger a law enforcement response
https://drugdatadecoded.ca/up-to-89-percent-of-ambulances-for-overdoses-concealed-in-record-year-as-alberta-health-care-careens-into-crisis-2/
In Philadelphia, on the new street drug medetomidine (a veterinary sedative known as “rhino tranq”)
https://idpc.net/news/2026/1/it-s-made-things-worse-for-everyone-philadelphia-grapples-with-the-rise-of-a-new-street-drug
Harm Reduction Research
On drug-checking services leading to the detection of a new street opioid, 5-cyano isotodesnitazene
Collaborative harm reduction efforts lead to the first detection of 5-cyano isotodesnitazene in illicit street drugs
https://www.nature.com/articles/s41598-026-35256-4
For harm reduction vending machines, a 23-month study found increased distribution of syringes, condoms, sharps containers & fentanyl test strips
Evaluating the Impact of Harm Reduction Vending Machines on Supply Distribution: A 23-Month Pre/Post Evaluation
https://www.researchsquare.com/article/rs-7787003/v1
For rural harm reduction, interviews on the benefits of public health vending machines
Expanding access to harm reduction in rural communities through community-informed public health vending machines
https://link.springer.com/article/10.1186/s12954-025-01395-6
For people who smoke crack cocaine, interviews on the positive impacts of safer inhalation devices
Safer inhalation devices: a rapid Health Impact Assessment of a harm reduction pilot for people who smoke crack cocaine
https://link.springer.com/article/10.1186/s12954-025-01383-w
In British Columbia’s safer supply program, on the characteristics of parents trying to access clean opioids
The characteristics and experiences of parents accessing prescribed safer supply in BC, 2020-2021
https://www.researchsquare.com/article/rs-7820725/v1
For police in New York City, interviews on their experiences with naloxone administration to reduce opioid overdoses
From law enforcement to public safety: Police officer experiences of naloxone administration to reverse opioid overdose in New York City
https://pmc.ncbi.nlm.nih.gov/articles/PMC12806846/
In Vancouver, a book chapter on the decriminalization of drug abuse & the police initiatives in the downtown area
The Decriminalization of Drug Abuse: Examining the Vancouver Police Initiatives in the Downtown Area
https://link.springer.com/chapter/10.1007/978-3-032-06680-0_15
In rural Black people who use drugs, a survey of the contributing factors as well as their feelings on medications for opioid use disorder
The Experiences and Attitudes of Rural Black People who Use Drugs
https://link.springer.com/article/10.1007/s40615-025-02798-8
For young sex workers use drugs, a commentary sharing their voices on removing barriers to accessing harm reduction services
What we need, not what we’re given: recommendations for action from young sex workers who use drugs
https://link.springer.com/article/10.1186/s12954-025-01357-y
🍄 Psychoactives, Psychedelics & Plant Medicines 🍄
On the rollout of psilocybin therapy across 3 US states
https://www.nytimes.com/2026/01/13/health/shrooms-lead-the-pack-in-psychedelic-medicine-but-rollout-is-bumpy.html
On microdosing, a new survey from RAND found ~10M US adults tried it last year
https://www.rand.org/pubs/research_reports/RRA4334-1.html
A book review of ‘Black Psychedelic Revolution’ by friend of the newsletter Dr. Nicholas Powers
Black Psychedelic Revolution: A reflective review
https://akjournals.com/view/journals/2054/aop/article-10.1556-2054.2025.00500/article-10.1556-2054.2025.00500.xml
A profile of Bruce Damer, friend of the newsletter & psychedelic visionary on the origins of life (see our 2017 interview here)
https://nautil.us/the-psychedelic-scientist-1254733/
On Terence McKenna, a loving review of ‘Strange Attractor: The Hallucinatory Life of Terence McKenna’ by Graham St John
https://psychedelicpress.substack.com/p/terence-mckenna
Plus, on a revival of McKenna’s ‘Stoned Ape’ theory by David Luke
https://substack.com/inbox/post/184200992
The Psychoactive Research
In drug researchers who use drugs, a commentary on the barriers discouraging disclosure
Speaking from experience: the case for openness about drug use among researchers
https://www.tandfonline.com/doi/abs/10.1080/09687637.2025.2599924
On the sanitization of psychedelics with non-hallucinogenic psychoplastogens by friend of the newsletter (and master of psychedelic animation) Dr. Ido Hartogsohn
Sanitizing psychedelics: the biopolitics of non-hallucinogenic psychoplastogens
https://link.springer.com/article/10.1057/s41292-025-00377-y
For seizures caused by cathinones (“bath salts”) & phenethylamines (like MDMA), a review of 42 cases, with most occurring in previously healthy adults & ~50% resulting in death
Triggers of highly lethal seizures induced by novel stimulants: A systematic review focused on synthetic cathinones and phenethylamines
https://www.sciencedirect.com/science/article/pii/S0161813X26000124
For unregulated kratom drinks, on challenges & policy recommendations
The Unregulated Rise of Kratom Drinks: Emerging Challenges and Policy Recommendations
https://journals.sagepub.com/doi/abs/10.1177/00333549251403378
For kratom, a case report & literature review of someone turning blue-gray from its use
Novel Histopathologic Features of Diffuse Blue-Gray Hyperpigmentation Associated With Kratom Use: A Case Report and Literature Review
https://pubmed.ncbi.nlm.nih.gov/41506249/
In breast cancer cells, kratom alkaloids inhibited proliferation & metastasis
Mitragyna speciosa Alkaloids Inhibit Proliferation and Metastasis in Luminal A and Triple-Negative Breast Cancer Mediated by AKT1 and Mortalin
https://assets-eu.researchsquare.com/files/rs-8421744/v1/b5261c4b-89dd-42c9-a53a-3b6fedee3b35.pdf
On khat chewing & community in young British-Somali men
Khat, community, and cultural expression: the performative experiences of young British-Somali men
https://www.tandfonline.com/doi/full/10.1080/02614367.2025.2611848
In Yemeni people chewing khat, they had reduced salivary flow & frequent oral dryness
Khat chewing, xerostomia, and unstimulated salivary flow among Yemeni adults: a cross-sectional comparative study using sialometry, the Clinical Oral Dryness Score (CODS), and the Summated Xerostomia Inventory (SXI-D)
https://assets-eu.researchsquare.com/files/rs-8462830/v1/e4ebe43f-ac33-4fd0-8fcc-0d05e905d9d3.pdf
In blood cells, cathinones altered their membranes
The Effect of Selected Cathinones on Natural Cell Membranes: Microelectrophoretic Methods
https://www.mdpi.com/1420-3049/31/2/234
Psychedelics & MDMA
In people with depression, this Brazilian longitudinal study found ayahuasca combined with therapy provided significant benefits for depression & anxiety, as well as potential for treating substance use disorders
THE THERAPEUTIC POTENTIAL OF AYAHUASCA IN DEPRESSION, GENERALIZED ANXIETY, AND SUBSTANCE USE DISORDERS: MODULATION OF THE DEPRESSIVE BURDEN IN A LONGITUDINAL STUDY
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1726909/abstract
In people with depression, low doses of LSD had potential antidepressant effects
Reward-related neural activity after low doses of LSD in participants with depressed mood
https://journals.sagepub.com/doi/abs/10.1177/02698811251405686
In psilocybin therapy in people with alcohol use disorder, their intensity of mystical experiences were associated with their intentions, spirituality & set & setting
Intentions, Spirituality, Set, and Setting Are Associated with Mystical Experiences in Psilocybin-Assisted Therapy
https://journals.sagepub.com/doi/full/10.1177/28314425251413425
For Parkinson’s disease & ibogaine, a case report of substantial improvements in motor symptoms, fatigue, depression & quality of life, but worse sleep quality
Ibogaine for the treatment of Parkinson’s disease: A case report
https://akjournals.com/view/journals/2054/aop/article-10.1556-2054.2025.00478/article-10.1556-2054.2025.00478.xml
For couples, a survey found that taking a psychedelic together was associated with greater shared reality & more positive relational changes, but taking a psychedelic alone was indirectly associated with the decision to end the romantic relationship
Associations of Couples’ Psychedelic Use with Shared Reality and Relational Well-Being
https://www.tandfonline.com/doi/abs/10.1080/02791072.2025.2607729
For psychedelic retreats, an analysis of their publicly advertised safety practices
Reported Safety Practices of Publicly Advertised Psychedelic Retreats
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2843513
On brain entropy as a biomarker of being in the psychedelic state, a review of the evidence
A critical review of brain entropy as a biomarker of the psychedelic state
https://www.researchgate.net/publication/399517348_A_critical_review_of_brain_entropy_as_a_biomarker_of_the_psychedelic_state
For 5-MeO-DMT, a review of the 33 human trials
5-MeO-DMT Use in Humans: A Scoping Review of Peer-Reviewed Research
https://www.researchgate.net/publication/399588580_5-MeO-DMT_Use_in_Humans_A_Scoping_Review_of_Peer-Reviewed_Research
For tablets sold as MDMA, an analysis of their adulterants since COVID
Psychoactive Synthetic Adulterants in Tablets Sold as MDMA after the COVID-19 Pandemic: Implications for Central Effects
https://www.benthamdirect.com/content/journals/cn/10.2174/011570159X410522251117060555
In a tissue model of Parkinson’s disease, DMT caused neuroprotective effects
NEUROPROTECTIVE EFFECTS OF DMT AGAINST 6-OHDA-INDUCED TOXICITY
https://www.croris.hr/crosbi/publikacija/prilog-skup/918357
Ketamine
For treatment-resistant depression, 8 weeks of ketamine combined with psychotherapy improved depressive symptoms
Ketamine Combined With Psychotherapy as a Treatment for Resistant Depression in a Public European Hospital
https://pmc.ncbi.nlm.nih.gov/articles/PMC12796847/
For treating bipolar disorder with ketamine, a review of the evidence found rapid improvements
Ketamine as an NMDA-Modulating Therapy in Bipolar Disorder: Rationale and Evidence
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1777402/abstract
For diabetes, a review of 11 studies on ketamine
Ketamine in Diabetes Care: Metabolic Insights and Clinical Applications
https://www.mdpi.com/1999-4923/18/1/81
🍃 The Plant & its Products 🍃
On creating new terminology for cannabis flowering to lessen confusion
Unraveling the Confusion of Flowering Types and Terminology in Cannabis sativa
https://journals.ashs.org/view/journals/hortsci/61/2/article-p396.xml
“We describe new terminology to differentiate between two types of female reproductive structures with subclassifications for specific female flower appearances. “Botanical pistillate flowering” refers to the day-neutral single pistillate flowers that appear at the nodes of female and monoecious plants. “Commercial pistillate flowering” leads to a distinctive compound inflorescence and is marked by the appearance of a domed structure with three stigma pairs on the dominant growing point in female and monoecious plants. Female flowering can be further described as “early- or late-stage incomplete commercial pistillate flowering.” Male reproductive structures develop into two forms. “Botanical staminate flowering” produces panicles with bell-shaped pedicellate flowers that have five petals, which open to reveal five anthers attached via anther filaments in male and monoecious plants. “Antheral flowering” is characterized by the appearance of single anthers or clusters of anthers that lack a pedicel and have no petals or filaments at the nodes or within the female inflorescence on monoecious plants.”
For the genetic diversity of cannabis, a review of domestication history, hybridization of events & regulatory policies
Unraveling the genetic diversity of Cannabis sativa L.: Phenotypic and molecular assessment, drivers of variation, and implications
https://www.researchgate.net/publication/399481510_Unraveling_the_genetic_diversity_of_Cannabis_sativa_L_Phenotypic_and_molecular_assessment_drivers_of_variation_and_implications
For the aroma & sensory lexicon of cannabis, a researcher interview on how this emerges from more than just the terpenes
GC-MS–Informed Aroma Profiling and Sensory Lexicon Development for Cannabis Inflorescence
https://www.chromatographyonline.com/view/gc-ms-informed-aroma-profiling-and-sensory-lexicon-development-for-cannabis-inflorescence
🌱 Growing & Extracting 🌱
In 3 different soil types, on the effects of adding hemp-derived materials on microbial functioning & carbon-nitrogen cycling
Short-Term Effects of Hemp-derived Amendments on Soil C and N Turnover and Microbial Efficiency across Three Soil Types
https://link.springer.com/article/10.1007/s42729-025-02900-3
For quality management in hemp growth, a study of the effects of fertilization, growth stimulant, sowing rate & preceding crops
Features of quality management of industrial hemp products (Cannabis sativa L)
https://www.jeeng.net/FEATURES-OF-QUALITY-MANAGEMENT-OF-INDUSTRIAL-HEMP-PRODUCTS-Cannabis-sativa-L-,216446,0,1.html
For vegetative propagation, on the effects of cutting position & leaf area retention
Effects of cutting position and leaf area retention on rooting and growth of vegetatively propagated Cannabis sativa
https://mail.horticultureresearch.net/title.php?a=1305
2025: Following gamma irradiation, cannabis buds continued to have toxic fungi & mycotoxins
Detection of Mycotoxigenic Fungi and Residual Mycotoxins in Cannabis Buds Following Gamma Irradiation
https://www.mdpi.com/2072-6651/17/11/528
On increasing cannabis storage stability with a combined extraction & spray-freeze-drying process
Combined extraction and spray-freeze-drying of Cannabis sativa Flos provides stable lyophilizate particles of cannabinoids
https://link.springer.com/article/10.1186/s42238-025-00381-w
For soilborne pathogens of hemp (& tomatoes), a thesis project on a systems approach
A Systems Approach to Soilborne Pathogen Management of Hemp and Tomato
https://www.proquest.com/openview/d0be0ff225accf1f6c9c3c2a8badfa03/1
For cannabis hairy root cultures, on using genetic editing tools to produce the bioactive compounds at an industrial scale
Revolutionizing Metabolic Engineering in Cannabis sativa L.: Harnessing the Power of Hairy Root Culture
https://www.proquest.com/openview/c3b8c31d42d5888857e030b88d3cd442/1
For 3 hemp cultivars, a genetic analysis of their cannabinoid & terpene synthesis
Population Structure of Genotypes and Genome-Wide Association Studies of Cannabinoids and Terpenes Synthesis in Hemp (Cannabis sativa L.)
https://www.mdpi.com/2223-7747/15/2/202
On using a drone for hemp monitoring
A Uav-based multisensor framework for legal industrial Cannabis monitoring and open-access dataset development
https://www.sciencedirect.com/science/article/pii/S2352340926000168
Fingerprinting cannabis seeds & leaves with an HPTLC
Pharmacognostic Characterization, Phytochemical Profiling, and High-Performance Thin-Layer Chromatographic (HPTLC) Fingerprinting of Cannabis sativa L. Seeds and Leaves
https://www.researchgate.net/publication/399453642_Pharmacognostic_Characterization_Phytochemical_Profiling_and_High-Performance_Thin-Layer_Chromatographic_HPTLC_Fingerprinting_of_Cannabis_sativa_L_Seeds_and_Leaves
Computer analysis of microsatellite DNA in different cannabis cultivars
In Silico Characterization and Microsatellite Analysis of the clpP Gene in Cannabis Cultivars
https://www.researchgate.net/publication/399052677_In_Silico_Characterization_and_Microsatellite_Analysis_of_the_clpP_Gene_in_Cannabis_Cultivars
⚙️ Analyzing & Formulating ⚙️
On creating self-healing microcapsules with hemp & other ingredients
Melamine–formaldehyde self-healing microcapsules added sisal/hemp/abaca reinforced polymeric composites for mechanical and thermal explorations
https://link.springer.com/article/10.1007/s00289-025-06270-9
On creating a CBD nanocarrier system for tunable release & better mucosal bioavailability
Chitosan-Modified Biodegradable Polymeric Nanoparticles for Tunable Cannabidiol Release and Enhanced Mucosal Transport
https://link.springer.com/article/10.1007/s10924-025-03740-z
On separating THC & other cannabinoids in gel separation tubes
Adsorption of Tetrahydrocannabinol (THC), Metabolites, and Related Cannabinoids During Storage of Plasma Samples in Gel Separation Tubes
https://academic.oup.com/jat/advance-article-abstract/doi/10.1093/jat/bkag001/8415997?redirectedFrom=fulltext
On processing hemp seeds into oil, on the optimum input & output parameters
Processing of Bulk Hemp Seeds by Estimating the Optimum Input and Output Parameters and the Description of the Theoretical Deformation Energy Under Uniaxial Compression Loading
https://www.preprints.org/frontend/manuscript/04d08f06e6ce5c0492d1aaf1532337ad/download_pub
🍞 Food & Nutrition & Hemp Seeds 🍞
In food containing CBD, a secret buyer analysis found only 2 products out of the 12 to be accurately labeled
Less than labelled, but more than safe: Quantification of cannabidiol content in food supplements and hemp seed oils using a validated UHPLC-PDA method
https://academic.oup.com/ijfst/advance-article/doi/10.1093/ijfood/vvag004/8417207
For extracting hempseed proteins, on the influence of pH & treatment
Influence of pH and Heat Treatment on the Physicochemical, Interfacial, and Emulsifying Properties of Hemp Seed Protein Dispersions
https://www.mdpi.com/2304-8158/15/2/257
For hemp protein hydrolysate, on improving its lipid regulation with an enzyme-bacterial synergistic approach
Structural characterization, physicochemical properties and hypolipidemic activity of hemp (Cannabis sativa L.) protein hydrolysates prepared via enzyme-microbial synergy
https://www.sciencedirect.com/science/article/abs/pii/S0963996926000293
🏗️ Industrial Uses & Fiber 🏗️
For protecting murals in Korean Buddhist shrines, on the best ways to incorporate hemp fiber
Properties of Infill Materials for the Earthen Wall Supporting the Mural in the Josadang Shrine, Buseoksa Temple
https://www.kci.go.kr/kciportal/landing/article.kci?arti_id=ART003287479
In 3 landscape shrubs, an analysis of hemp hurd fiber as a substrate for their container production
Performance of Container Landscape Plants in Media with Hemp Hurd Fiber Substituted for Peat
https://journals.ashs.org/view/journals/hortsci/60/12/article-p2417.xml
On cleaning lead from soils with hemp & the synergistic effects of vermicompost & cerium oxide nanoparticles
Synergistic effect of cerium oxide nanoparticles and vermicompost on hemp productivity under lead contaminated soils
https://www.sciencedirect.com/science/article/pii/S0926669025021247
On the potential of papermaking from hemp stubble
Papermaking potential of pulps from bast, hurd and stubble of hemp; separately and blended with pine pulp
https://link.springer.com/article/10.1007/s10570-026-06935-2
On improving waste pulp papermaking from hemp with laccase–pectinase pretreatment
Customized Hemp Pulp Extraction via Laccase–Pectinase Pretreatment for Improved Waste Pulp Papermaking
https://pubs.acs.org/doi/full/10.1021/acsomega.5c07384
On creating wood-sodium silicate composites with hemp hurd & fibers
Optimizing Wood–Hemp–Sodium Silicate Composites for Strength, Extrudability, and Cost in Additive Manufacturing Applications
https://www.mdpi.com/1996-1944/19/2/357
Analyzing a rubber hemp shive composite & its acoustic & thermal properties
Acoustic and thermal insulation properties of rubberhemp shive composite bonded with regenerated polyurethane resin
https://www.nature.com/articles/s41598-026-35411-x_reference.pdf
For a hemp epoxy biocomposite, on the effects of alkaline treatment & weathering on their mechanical properties
Effect of alkaline treatment and weathering on the mechanical properties, failure mechanisms and service life of jute, hemp, and sisal fiber-reinforced epoxy biocomposites
https://www.sciencedirect.com/science/article/pii/S2352492826000450
Combining hemp fiber & langsat fruit shells reduced moisture uptake & improved mechanical integrity & thermal resistance
Development of Sustainable Silane-Treated Hemp Fiber and Lansium parasiticum Shell Bio-Filler-Reinforced Polyester Composite
https://ojs.bioresources.com/index.php/BRJ/article/view/25105
For the 3D printing of hempcrete in construction, a review of the advantages & challenges
A Review of Advantages and Challenges of Using Hempcrete for 3D Printing in Construction
https://www.sciencedirect.com/science/article/pii/S2352710226001191
On creating rebar from hemp-reinforced thermoplastic
Design of a Pultrusion System for a Hemp-Based Rebar
https://link.springer.com/chapter/10.1007/978-3-032-05220-9_14
For bio-based concretes, hemp-based concretes combined with CEMIV exhibited the highest flexural performance
Evaluating the flexural performance of bio-based concrete with different types of bio-aggregate and binder
https://www.sciencedirect.com/science/article/pii/S0950061826000760
🌿 THE CANNA-SCIENCE ARCHIVE 🌿
For gendered differences in the acute effects of cannabis, a commentary urging the need for more hypothesis-driven research
Sex differences in the acute effects of cannabis: the need for hypothesis-driven research
https://cdnsciencepub.com/doi/pdf/10.1139/jpn-2025-0164
🏥 Public Health, Legalization Effects & Bioassays 🏥
In French people illegally obtaining cannabis, a survey found their most common sources to be friends, relatives or dealers
Factors associated with different cannabis supply methods: results from the French 2017 ESCAPAD and Health Barometer surveys
https://link.springer.com/article/10.1186/s42238-025-00372-x
For cannabis breathalyzers, on the vapor pressure measurements of THC, CBD & CBN
Vapor pressure measurements on Δ9 -tetrahydrocannabinol, cannabidiol, and cannabinol to inform cannabis breathalyzer development
https://iopscience.iop.org/article/10.1088/1752-7163/ae3794/pdf
In human blood, a rapid test for quantifying CBD & its metabolites 7-OH-CBD & 7-COOH-CBD
A simple, sensitive and rapid bioanalytical method for quantifying cannabidiol (CBD), 7-OH-CBD and 7-COOH-CBD in human plasma
https://www.tandfonline.com/doi/abs/10.1080/17576180.2026.2612921
For quantifying cannabinoids in blood, on validating a highly sensitive liquid chromatography–tandem mass spectrometry (LC-MS/MS) method
Validation of a Microsampling-Compatible Liquid-Liquid Extraction Method for Cannabinoid Quantitation in 50 µL of Whole Blood using LC-MS/MS
https://academic.oup.com/jat/advance-article/doi/10.1093/jat/bkag004/8419878
🧒 Adolescents & Young Adults 🧒
In young adults having sex under the influence of cannabis, interviews on their motivations & the gendered dynamics
“It’s a Beautiful Feeling”: Exploring Embodied, Psychological, and Gendered Motivations for Sex Under the Influence of Cannabis Among Young Adults
https://www.tandfonline.com/doi/pdf/10.1080/00224499.2025.2604775
In adolescents with cannabinoid use disorder order versus synthetic cannabinoid use disorder, there was more systemic inflammation in those with synthetic cannabinoid use disorder
Synthetic Cannabinoid Use is Associated with Higher Systemic Inflammatory Indices than Cannabis Use in Adolescents
https://link.springer.com/article/10.1007/s11469-025-01622-y
In German adolescents, public health data on the prevalence of cannabis-related disorders
Trends in the diagnostic prevalence of cannabis-related disorders and co-occurring psychiatric disorders in adolescents: analysis of German health insurance data from 2013 to 2022
https://academic.oup.com/eurpub/advance-article/doi/10.1093/eurpub/ckaf228/8419957
For preteens who experienced racial/ethnic discrimination, they had higher cannabis use intention & lower perceived cannabis harm
Pathways from racial/ethnic discrimination experience to cannabis use intentions: a longitudinal study of the mediating roles of perceived accessibility and harm among preteens
https://www.tandfonline.com/doi/abs/10.1080/15332640.2025.2612339
In adolescents with depression, they had lower blood levels of endocannabinoid & oxylipins
Altered Plasma Endocannabinoids and Oxylipins in Adolescents with Major Depressive Disorders: A Case–Control Study
https://www.mdpi.com/2072-6643/18/2/280
In brain scans of adolescents using cannabis or e-cigarettes, they had blunted reward activity & behavioral disinhibition
Blunted reward-related striatal activity and behavioral disinhibition as a pathway to adolescent cannabis and e-cigarette use
https://www.frontiersin.org/journals/adolescent-medicine/articles/10.3389/fradm.2026.1741884/abstract
In US teens with sports-related traumatic brain injuries, the prevalence was higher among those using synthetic cannabinoids
Synthetic Cannabinoid Use and Sports‐Related Concussion Risk Among US Adolescents: Implications for School Health Screening and Prevention
https://onlinelibrary.wiley.com/doi/pdf/10.1111/josh.70112
In early adolescence, an analysis of the 4 trajectories of cannabis use with the most important factors being family related
Developmental Trajectories of Positive Expectancies of Cannabis Use Effects Among Early Adolescents: Longitudinal Observational Study Using Latent Class Growth Analysis
https://publichealth.jmir.org/2026/1/e85652
In US young adults, on their perceptions of psychedelics & cannabis & the influence of adverse childhood experiences
Cannabis and Psychedelics Among U.S. Young Adults: Use, Messaging Exposure, Perceptions, and Legalization Support
https://www.preprints.org/frontend/manuscript/06537eadc44b9523d7d4cd3e52c910ba/download_pub
In college students, unsurprisingly, the use of non-prescribed pharmaceutical drugs was associated higher alcohol & cannabis use & the misuse of prescribed pharmaceuticals was linked to higher cannabis use
Relations between medical and nonmedical prescription stimulant misuse, cannabis use, alcohol use, and related consequences among college students
https://psycnet.apa.org/record/2027-10016-001
In young adults co-using alcohol & cannabis, the quantity of alcoholic drinks was associated with a higher likelihood of negative consequences
Alcohol quantity mediates the association between daily alcohol and cannabis co-use and alcohol consequences
https://www.sciencedirect.com/science/article/pii/S0376871626000244
In brain scans of youth using alcohol & cannabis, cannabis use was associated with higher triple-network connectivity of the default mode network, executive control network & salience network
Associations Between Youth Marijuana and Alcohol Use, Neurocognitive Performance, and Triple-Network Resting-State Connectivity
https://www.sciencedirect.com/science/article/pii/S2451902226000030
In young adults, on their reasons for the co-use of nicotine & cannabis
A qualitative study of same session co-use of nicotine and cannabis among adolescents and young adults
https://journals.plos.org/plosone/article
In adolescents vaping nicotine, public health data found associating with rule-breaking peers increased the likelihood of cannabis use
Social Learning Theory and Gateway Hypothesis as a Causal Pathway Linking Rule-Breaking Peer Association to Marijuana Use via Nicotine Vaping
https://www.tandfonline.com/doi/abs/10.1080/02791072.2026.2614509
In a mouse model of cognitive deficits from the adolescent ingestion of THC, the release of glutamate (the brain’s most common excitatory neurotransmitter) in the astrocytes (the brain’s most common support cell) was required within the circuit between the hippocampus (a memory center of the brain) & nucleus accumbens (a reward center & regulator of feeding, stress & motivation)
An astrocytic ensemble at vHip-NAc synapses modulates cognitive impairments induced by chronic tetrahydrocannabinol exposure
https://econpapers.repec.org/article/natnatcom/v_3a17_3ay_3a2026_3ai_3a1_3ad_3a10.1038_5fs41467-025-67166-w.htm
In a tissue model of a young human prefrontal cortex, THC exposure shifted neurodevelopmental gene expression towards autism
Dual Transcriptomic and Epigenomic Signatures of THC Exposure in Human Prefrontal Cortex Development
https://www.biorxiv.org/content/10.64898/2026.01.08.698442v1.full.pdf
🧠 The Brain & Neurological Disorders 🧠
For Parkinson’s disease, a review of targeting the CB2 receptor, the GPR55 receptor (which one they may be known as CB3) & the nuclear receptor PPARγ (that controls genetic transcription)
Development of cannabinoid-based therapies for Parkinson’s disease: emphasis on targeting cannabinoid receptors as CB2, PPAR-γ and GPR55 receptors
https://link.springer.com/article/10.1186/s44477-025-00016-7
For neurodegenerative disorders, a book chapter on the use of cannabinoids
Potential Therapeutic Strategy for Neurodegenerative Disorders: Insights from Natural Cannabis Compounds and Analogues
https://link.springer.com/chapter/10.1007/978-3-031-95878-6_11
For multiple sclerosis & cannabinoids, a book chapter with a focus on nano-cannabinoids
Cannabinoids and Multiple Sclerosis: Insights Into Therapeutics, Mechanisms, and Patient Outcomes
https://www.igi-global.com/chapter/cannabinoids-and-multiple-sclerosis/399570
In a mouse model of Down syndrome, suppressing the enzyme MAGL (which synthesizes the endocannabinoid 2-AG) partially restored neurogenesis (the birth of new brain cells)
Chronic suppression of monoacylglycerol lipase restores adult neurogenesis in the septal but not the temporal DG in Ts65Dn mouse model of Down syndrome
https://www.sciencedirect.com/science/article/pii/S0361923026000079
In a mouse model of frontotemporal dementia, on the changes to their gut endocannabinoidome & microbiome
Defining the Intestinal eCBome and Oxylipin Signaling Systems in a TDP-43 Mouse Model of Frontotemporal Dementia
https://pubmed.ncbi.nlm.nih.gov/41524247/
💭 Mental Health, Addiction & Cannabis Use Disorder 💭
In humans with intrusive memories after trauma, lower blood anandamide levels were associated with higher explicit & intrusive memories
Complex relationship between endocannabinoids, fatty acid amide hydrolase, and stress reactivity in human intrusive memories of analogue trauma
https://www.sciencedirect.com/science/article/pii/S0278584626000060
In people with a diagnosis of a psychotic disorder, Washington State public health data found that they had the greatest risk for cannabis-related problems, including nausea, heart or blood pressure problems, fainting, acute psychosis or hallucinations, flashback & cannabis hyperemesis syndrome
People with psychotic disorders are the most vulnerable to cannabis adverse health outcomes: a study in WA State, USA
https://link.springer.com/article/10.1007/s10597-025-01579-1
In sexual minority women & gender diverse individuals, on the factors leading to more cannabis use than intended included social use & coping motives
Daily risk factors for using more alcohol and cannabis than intended: An examination of contextual and motivational risk factors among sexual minority women and gender diverse individuals
https://pmc.ncbi.nlm.nih.gov/articles/PMC12799242/
For cannabis use disorder, a longitudinal study on using weekly standard THC units for differentiating risk
Estimating thresholds for risk of cannabis use disorder using standard delta‐9‐tetrahydrocannabinol (THC) units
https://onlinelibrary.wiley.com/doi/pdf/10.1111/add.70263
For people trying to quit tobacco, a survey found the lowest interest from people co-using cannabis & the greatest barriers in those with cannabis use disorder
The impact of cannabis co-use and cannabis use disorder on interest in and barriers to tobacco cessation
https://www.sciencedirect.com/science/article/abs/pii/S030646032600016X
In a liver tissue model of nicotine metabolism, delta-8 THC increased levels via the CYP2A6 enzyme, suggesting it as a potential for smoking-cessation therapy
Inhibitory effects of Δ8-tetrahydrocannabinol on nicotine metabolism and implications as a smoking cessation agent
https://www.sciencedirect.com/science/article/pii/S0090955626000048
For cannabis cue-reactivity studies in people with cannabis use disorder, a commentary on considerations for that type of research
Considerations for Neural Cannabis Cue-Reactivity Studies in Individuals With Cannabis Use Disorder
https://www.sciencedirect.com/science/article/pii/S266717432500223X
In a mouse model of depression treated with fluoxetine (Prozac), behavioral improvements were associated with higher levels of the endocannabinoid 2-AG in the hippocampus (a memory center of the brain)
2-AG as a potential biomarker for predicting response to short-term fluoxetine treatment in a mouse model of depression
https://www.biorxiv.org/content/10.64898/2026.01.14.699270v1.full.pdf
On creating a duel-hit mouse model of schizophrenia by combining maternal immune system activation with postnatal THC exposure & on the potential of the protein Reelin as a biomarker
Disruption of Reelin signaling in a dual-hit mouse model of schizophrenia: impact of postnatal Δ9-tetrahydrocannabinol exposure in a maternal immune activation model
https://www.researchsquare.com/article/rs-7299003/v1
🧬 Reproduction & Hormones 🧬
In a rat model of polycystic ovary syndrome, an industry study of a hemp seed powder found reduced cyst formation, lowered symptoms & regulated hormonal levels & the estrous cycle
Study of hemp tribe HEMPOWHER granules on DHEA- induced PCOS in Sprague Dawley (SD) rat model
https://d1wqtxts1xzle7.cloudfront.net/125998420/ijcaap_journal_volume_10_issue_2_article_24299-libre.pdf
In an animal model of prenatal fentanyl & cannabis exposure, a thesis project found the offspring had impaired working memory, social behavior, temperature regulation & cardio health with gendered differences
Developmental Programming by In Utero Opioid and Cannabis Exposure: Impacts on Offspring Neurocognitive and Cardiometabolic Health
https://ruor.uottawa.ca/items/becfa04d-f956-42a7-9650-053c4a997987
In the sperm of humans & other animals, an analysis of the location of CB1 receptors found them to be important for regulating DNA dynamics
From localization to function: comparative analysis of CB1 in sperm across species and its epigenetic role in humans
https://www.nature.com/articles/s41419-025-08386-2_reference.pdf
In the sperm of mice, on how sperm motility was modulated by 2-AG, which was regulated by MAGL, ABHD6 & ABHD12
Investigation of endocannabinoid 2-AG and its hydrolases for regulation on sperm motility and acrosome reaction in Kunming mice
https://connectsci.au/rd/article/doi/10.1071/RD25040/268095/Investigation-of-endocannabinoid-2-AG-and-its
In pregnant cannabis users waiting to enter treatment facilities, something happens behind a paywall…
EPH24 Associations Between Waiting Time and Treatment Completion Among Treatment-Naive Pregnant Cannabis Users Admitted to Treatment Facilities in the United States
https://www.valueinhealthjournal.com/article/S1098-3015(25)03710-6/abstract
🦠 The Immune System & Microbial 🦠
In a mouse model of flu infection, activating their CB2 receptor reduced disease severity & enhanced survival
Targeting the Endocannabinoid System: Cannabinoid Receptor 2 Activation Modulates Outcomes in Influenza A Virus Infection – Insights from a Murine Model
https://pmc.ncbi.nlm.nih.gov/articles/PMC12793294/
🦴 Pain, Musculoskeletal & Surgeries 🦴
In people with chronic musculoskeletal pain using cannabis, interviews using the Theory of Planned Behavior on their motivations (which were, unsurprisingly, pain)
The theory of planned behavior partly explains why adults with chronic musculoskeletal pain consider using medical cannabis for pain management
https://www.nature.com/articles/s41598-025-33616-0_reference.pdf
For new CBD analogues, on their anti-inflammatory & painkilling effects
Pharmacological characterization of the anti-nociceptive and anti-inflammatory effects of new CBD-based terpenyl-N-acyl-aryl-hydrazone analogues
https://www.sciencedirect.com/science/article/pii/S0753332225011199
❤️ The Heart & Blood ❤️
In people with myocarditis (heart inflammation), 12 weeks of CBD only improved one of the parameters measured (reduction in left ventricle mass)
Impact of cannabidiol on myocardial recovery in patients with acute myocarditis: primary results of the ARCHER study
https://academic.oup.com/eschf/advance-article/doi/10.1093/eschf/xvaf034/8427108
In mice with no GPR18 receptor (which one day may be known as CB4), they had alterations to their blood vessels, the thoracic aorta & femoral artery
GPR18 Deletion in Mice Inversely Affects Vasoactive Signaling and Passive Biomechanical Properties of the Thoracic Aorta and Femoral Artery
https://www.mdpi.com/1422-0067/27/2/841
🍽️ The Guts, Nutrition & the Microbiome 🍽️
On cannabinoid hyperemesis syndrome, a white paper proposing that it’s a complex neuroendocrine & metabolic disorder
Cannabinoid Hyperemesis Syndrome as an Endocrine–Metabolic Disorder: FAAH Dysfunction, CYP450 Inhibition, Cortisol Dysregulation and Sex-Steroid Disruption in Chronic Cannabis Use
https://www.scienceopen.com/document_file/c369fbd6-61b5-4974-846a-815c9d640353/ScienceOpenPreprint/Cannabinoid%20HyperEmesis.pdf
In a tissue model of colitis, the endocannabinoid-derived prostaglandin glycerol esters & prostaglandin ethanolamides modulated intestinal inflammation
The endocannabinoid-derived prostaglandin glycerol esters and prostaglandin ethanolamides modulate intestinal epithelial hallmarks of colitis
https://www.sciencedirect.com/science/article/abs/pii/S1388198126000053
🖐️ The Skin & Topicals 🖐️
In people who had a panniculectomy surgery (removal of excess abdominal skin), those with cannabis use disorder had significantly higher rates of postprocedural pain & skin complications
Association of cannabis use disorder with postoperative complications following panniculectomy: a multicenter propensity-matched analysis
https://link.springer.com/article/10.1186/s44452-026-00013-z
In people with atopic dermatitis (eczema), a cream of CBD & cherimoya fruit extract decreased itchiness & dryness while improving redness & skin barrier function
Efficacy and Safety of a Cannabinoid-Based Topical Cream in Atopic-Prone Skin: A Prospective Clinical Study
https://www.mdpi.com/2079-9284/13/1/20
For a nickel allergy of the skin, a proposal on the use of the endocannabinoid PEA
Palmitoylethanolamide for Nickel Allergy: Plausible, Untested, and Worth Considering
https://www.mdpi.com/2227-9059/14/1/177
In a tissue model of dermatomyositis (an autoimmune disease of the skin and muscles & longs), the CB2 receptor activating drug Lenabasum downregulated pro-inflammatory cytokines
Lenabasum, a cannabinoid type 2 receptor agonist, exerts anti-inflammatory effects in Dermatomyositis
https://www.sciencedirect.com/science/article/abs/pii/S0022202X26000072
🎗️ Cancer & Chemotherapy 🎗️
In people with pancreatic cancer & chronic pancreatitis, those with cannabis use disorder had lower rates of pancreatitis at follow-up
Cannabis Use Disorder and Risk of Pancreatic Cancer in Patients with Chronic Pancreatitis: a Multicenter Retrospective Cohort Study
https://link.springer.com/article/10.1007/s12029-025-01383-w
In melanoma cells, a combination of CBD & CBG limited migration & invasion & caused antitumor effects
Phytocannabinoids influence phospholipid metabolism of melanoma cells: Modulation of in vitro effects of the UVA irradiation
https://www.sciencedirect.com/science/article/pii/S0753332226000351
In colorectal cancer cells, CBD caused stronger antitumor effects than CBD acid, but a full spectrum CBDA-rich extracted better than both
The differential effects of CBD and CBDA on viability and mRNA expression in colorectal cancer cells
https://link.springer.com/article/10.1186/s42238-026-00391-2
In liver cancer, a review on the potential of cannabinoids & their targets of ion channels
Cannabidiol–Ion Channel Interactions Represent a Promising Preventive and Therapeutic Strategy in Hepatocellular Carcinoma
https://www.mdpi.com/1873-149X/33/1/8
In cells of glioblastoma (the most aggressive brain cancer), the endocannabinoids anandamide & oleamide increased oxidative damage & lowered proliferation via the mitochondria (powerhouse of the cell)
The Anti-proliferative Effects of Anandamide and Oleamide in Glioblastoma Cell Lines Recruit Mitochondrial and PPAR-γ Receptor Modulation
https://link.springer.com/article/10.1007/s11064-025-04654-x
For colorectal cancer cells, on using CBD to test a framework for identifying molecular targets called “stability- and degradation-based proteome profiling” (SDPP)
Stability and Degradation-based Proteome Profiling Reveals Cannabidiol as a Promising CDC123-eIF2γ Inhibitor for Colorectal Cancer Therapy
https://pubs.acs.org/doi/abs/10.1021/jacs.5c20040
💊 Synthetic Cannabinoids & Hemp-Derived Cannabinoids 💊
In Europe, an analysis of the rise of semi-synthetic cannabinoids & their public health effects
Semi-synthetic cannabinoids: recent developments, analytical challenges and strategic responses
https://www.sciencedirect.com/science/article/abs/pii/S0379073826000101
For 11 synthetic cannabinoids identified by the DEA, a test on their behavioral effects in rats
Behavioral pharmacology of novel synthetic indazole, indole, and benzimidazole cannabinoids in rodents
https://link.springer.com/article/10.1186/s42238-026-00390-3
For those of you keeping score at home, they are ADB-BUTINACA, ADB-HEXINACA, ADB-4en-PINACA, ADB-FUBIATA, 4F-MDMB-BICA, 4F-ABUTINACA, FUB-144, FUB-AKB-48, 5F-EMB-PICA, 5Cl-AKB-48 & MDA-19.
For the synthetic cannabinoid 5F-ADB, on identifying the toxicity & metabolites
Multi-level metabolic Profiling of Synthetic Cannabinoid 5F-ADB: Identifying Definitive Biomarkers for Forensic Source Tracking and Ecotoxicological Risk Assessment
https://academic.oup.com/etc/advance-article-abstract/doi/10.1093/etojnl/vgag003/8417629
In zebrafish & human liver tissue, on the metabolites of the synthetic cannabinoids 5F-ADB-PINACA & 5F-ADBICA
Study on Phase I Metabolic Processes and Metabolite Biomarker Identification of Synthetic Cannabinoids 5F-ADB-PINACA and 5F-ADBICA in Human Liver Microsomes and Zebrafish Model
https://www.mdpi.com/1420-3049/31/2/250
For detecting synthetic cannabinoids in hair, a review of methodologies for using liquid chromatography coupled to mass spectrometry
Synthetic cannabinoids in hair: a review of recent findings and analytical methods by LC-MS/MS
https://www.sciencedirect.com/science/article/abs/pii/S0003267026000280
🔬 Biochemical Discoveries & Research Tools 🔬
In mutated CB1 & CB2 receptors, a computer analysis searching for peptides to fix signaling
In-silico and In-vitro role of chimeric peptide on the impact of nsSNPs in human Cannabinoid receptors 1 and 2
https://www.sciencedirect.com/science/article/abs/pii/S0010482526000119
On light-controlled drugs to activate the cannabinoid & TRPV1 receptors
Light-Controlled Modulation of the Endocannabinoid System: Photoswitchable Ligands for Cannabinoid and TRPV1 Receptors
https://www.mdpi.com/1422-0067/27/2/573
A new AI for molecular design was fine-tuned on our beloved enzyme FAAH (which breaks down anandamide)
FRAIL: fragment-based reinforcement learning for molecular design and benchmarking on fatty acid amide hydrolase 1 (FAAH-1)
https://link.springer.com/article/10.1007/s11030-025-11448-4
Thanks.
- lex
PS: For today’s long-lived & prolific practitioner of the West Coast blues, the pianist, singer & songwriter Jimmy McCracklin on his album ‘I Had To Get With It: The Best Of The Imperial & Minit Years’. Growing up in Missouri & serving in the Navy during World War II, McCracklin moved to the West Coast & started recording in 1945. He spent the next decade recording with many tiny labels from Los Angeles to Oakland, his first big hit coming with 1958’s ‘The Walk’ (first track on this album). It put him in the Top 10 on both the pop & R&B charts & catapulted him to national TV fame. He kept creating hits throughout the ‘60s & segued into soul music when that was the thing to do. Throughout the 80s & 90s, he continued to tour & produce new albums. He said he wrote almost a thousand songs over his career & we know he recorded hundreds of them, continuing to write, record & perform into the 21st century. Finally, after 91 years on this earth, Jimmy McCracken went home to the blues club in the sky.
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Hey, Lex, this article comes at such a perfect time. I'm always super curioius about the science behind all this. Just wondering about the bone repair bit. Is it like, it helps but also has a drawback? A real double-edged sword, huh?