C&P#74: CBD for autoimmune disorders & sports + hemp seed oil for menopause
Who coined medical marijuana?
Hello everyone,
Welcome to the 74th edition of Cannabinoids & the People, a weekly newsletter where I collect all the new cannabinoid science. You can check out last week’s issue here & if you haven’t subscribed yet, please do.
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Read my free How-To Guides, watch my Three-Minute Cannabinoid Science videos or book a session with me here.As always, here’s the Glossary of Cannabinoid Terms & at the bottom is the album of the week.
Announcements:
I finished my update of the CVResearch.info site. With all the newest 2023 data as well as new pages on the minor cannabinoids, it’s a wide-ranging archive on cannabinoid science that I’m quite proud of. Ask me anything.
This week…
CBD for multiple autoimmune disorders
Prehistoric humans teach us to run until you feel high & then make some art
Hemp seed oil for menopausal depression
A big week for endocannabinoids as biomarkers for disease identification & differentiation
A lot of preclinical work on Alzheimer’s
Antiviral cannabinoids
Big load of psychedelic research & writing
A request to spread the word
This newsletter only spreads by word of mouth,
so please forward to colleagues & tell your friends & relatives.
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My work this week:
Canna-Education for CV Sciences
(TikTok:@cvsciences or my YouTube playlist 3-minute Cannabinoid Science):
CV Sciences Official Statement: TCH-O & delta-8-THC-O
Multiple Sclerosis & the Cannabinoids
Cannabinoids & Neuropathic Pain
Effects of Prenatal Cannabis Exposure
Pregnancy: Hyperemesis Gravidarum vs Cannabinoid Hyperemesis Syndrome
Cannabis & CBD: Heart Harms & Heart Help (20k views)
Apoptosis & the Cannabinoids
Cannabis & Massage
Differences Between Medical & Recreational Cannabis
My TikToks (@lexpelgerandhisbooks or on YouTube):
Tarot as the Tree of Life
Sciencemancy: Genome to Drug Pipeline
Sciencemancy: AI & Flocks of Autonomous Drones
Why Memory Palaces?
A VR Memory Palace <swoon>
My platforms: Linktree
YouTube for educational videos, lectures & shorts on new cannabinoid science
Anandamide; or, the People: my graphic novel series on cannabis, the endocannabinoid system & the War on Drugs based on Moby-Dick
My podcasts
LinkedIn, Twitter & my TikTok on books, hermeticism, science & history
Ways to support this work:
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Best Of Cannabinoid Science...
A unique study on how prehistoric humans used persistence hunting & how that would have activated the endocannabinoid system to cause an altered state & how that can be seen in the rock art
Fragments of the hunt Persistence hunting approach to rock art
https://tuhat.helsinki.fi/ws/files/273942616/Fragments_of_the_hunt_Persistence_hunting_approach_to_rock_art_Mikko_R_Ija_s_Hunter_gatherer_research_Published_but_without_layout.pdf
For veterinarians, what to do with a pet THC intoxication
A New High and a New Low: An Unusual Case of THC Intoxication
https://todaysveterinarynurse.com/emergency-medicine-critical-care/unusual-case-report-of-thc-intoxication/
Clinical
In patients with osteoarthritis, a combination of hemp seed oil & terpenes lowered inflammation via IL-1β & IL-6 levels
Effects of Terpenes on the Osteoarthritis Cytokine Profile by Modulation of IL-6: Double Face versus Dark Knight?
https://pubmed.ncbi.nlm.nih.gov/37626947/
A case study of using CBD for multiple autoimmune disorders
Cannabidiol in the Management of Comorbid Rheumatoid Arthritis, Lupus, and Raynaud’s Disease
https://www.endocannabinoidmedicine.com/academicarticle/cannabidiol-in-the-management-of-comorbid-rheumatoid-arthritis-lupus-and-raynauds-disease/
In people who had bariatric surgery, cannabis use was associated with increased levels of anxiety as well as increased “loss of control” eating, grazing, binge eating, night eating & eating in response to depression
Cannabis use following bariatric surgery is associated with anxiety and maladaptive eating
https://www.sciencedirect.com/science/article/abs/pii/S1550728923006962
In children with treatment resistant epileptic encephalopathies (where the seizures cause progressive cerebral dysfunction), CBD absorption was increased with food, a ketogenic diet or the drug levothyroxine
Real-World Evidence of Factors Affecting Cannabidiol Exposure in Children with Drug-Resistant Developmental and Epileptic Encephalopathies
https://pubmed.ncbi.nlm.nih.gov/37631333/
“The multivariate model showed a 109.6% increase in CBD C0 in patients with concomitant levothyroxine (β = 0.74 ± 0.1649, p < 0.001), 56.8% with food (β = 0.45 ± 0.1550, p < 0.01), and 116.0% after intake of a ketogenic diet (β = 0.77 ± 0.3141, p < 0.05).”
And a very cool thesis project on the high brain temperatures in treatment resistant epilepsy being lowered by CBD
The Effects of Cannabidiol on Brain Temperature in Treatment-Resistant Epilepsy
https://www.proquest.com/openview/1eec8641f15aecfecbe58cb3797ccdf6/1?pq-origsite=gscholar&cbl=18750&diss=y
A study of older participants matching their circulating endocannabinoids with their blood biomarkers of neuro-injury, though their main finding was related to gender differences
The association of circulating endocannabinoids with neuroimaging and blood biomarkers of neuro-injury
https://pubmed.ncbi.nlm.nih.gov/37700370/
“After adjustment for potential confounders and correction for multiple comparisons, no statistically significant associations were observed between eCB [endocannabinoid] levels and the study outcomes [brain MRI measures & blood biomarkers of Alzheimer’s disease & neural injury]. However, we identified multiple sex-specific associations between eCB levels and the various study outcomes. For example, high linoleoyl ethanolamide (LEA) levels were related to decreased hippocampal volume among men and to increased hippocampal volume among women”
In people with a first episode psychosis, those using cannabis were associated with a higher risk of later conversion to schizophrenia
The transition to Schizophrenia spectrum disorder from a first psychotic episode that did or did not appear to be induced by substance use
https://pubmed.ncbi.nlm.nih.gov/37713923/
And a large meta-analysis of cannabis use & schizophrenia could not decide if cannabis was detrimental or beneficial for positive or negative symptoms
Association between cannabis use and symptom dimensions in schizophrenia spectrum disorders: an individual participant data meta-analysis on 3053 individuals
https://pubmed.ncbi.nlm.nih.gov/37731936/
Interviews on how to quit cannabis if you have a mental illness
How to quit cannabis when you have a mental illness: study from the perspective of patients who have successfully quit
https://pubmed.ncbi.nlm.nih.gov/37694506/
On the differences in cannabis related problems between Queer people & and non-Queer people
Evaluating age-related disparities in cannabis-related problems among LGBT+ versus non-LGBT+ adults
https://pubmed.ncbi.nlm.nih.gov/37748224/
A thesis project on how many dogs are being poisoned by cannabinoids in the US
Epidemiology of Opioid and Cannabinoid Poisoning Events in US Companion Dogs, 2005-2014
https://atrium.lib.uoguelph.ca/server/api/core/bitstreams/bd97ee80-f96f-4857-8dec-1e088e4ca678/content
Reviews
A review on how CBD could help in sports performance & recovery
Cannabidiol in sports: insights on how CBD could improve performance and recovery
https://www.frontiersin.org/articles/10.3389/fphar.2023.1210202/full
For skin diseases, a review of the minor cannabinoids
Therapeutic Potential of Minor Cannabinoids in Dermatological Diseases-A Synthetic Review
https://pubmed.ncbi.nlm.nih.gov/37630401/
A huge meta-analysis of everything good & bad about cannabis
Balancing risks and benefits of cannabis use: umbrella review of meta-analyses of randomised controlled trials and observational studies
https://pubmed.ncbi.nlm.nih.gov/37648266/
Reese & Hulse with two more strong review papers about the negatives of cannabis on gene expression, DNA damage, epigenetic changes & increased aging
Perturbation of 3D nuclear architecture, epigenomic dysregulation and aging, and cannabinoid synaptopathy reconfigures conceptualization of cannabinoid pathophysiology: part 1–aging and epigenomics
https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1182535/full
Perturbation of 3D nuclear architecture, epigenomic aging and dysregulation, and cannabinoid synaptopathy reconfigures conceptualization of cannabinoid pathophysiology: part 2—Metabolome, immunome, synaptome
https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1182536/full
A review of CBD's molecular actions
Molecular and Cellular Mechanisms of Action of Cannabidiol
https://pubmed.ncbi.nlm.nih.gov/37630232/
For obesity & depression, a review of targeting the endocannabinoids activated by exercise & the kynurenines (an amino acid that regulates immune response)
Crosstalk between Exercise-Derived Endocannabinoidome and Kynurenines: Potential Target Therapies for Obesity and Depression Symptoms
https://www.mdpi.com/1424-8247/16/10/1421
A review of the advances in cannabinoid & endocannabinoid research
Molecular Advances on Cannabinoid and Endocannabinoid Research
https://pubmed.ncbi.nlm.nih.gov/37628940/
A review on the links between cannabis use & violence
Illicit drug use and violence
https://pubmed.ncbi.nlm.nih.gov/37633705/
Preclinical
In a rat model of menopausal depression, the prophylactic effects of hemp seed oil via the HPA axis
Prophylactic Effects of Hemp Seed Oil on Perimenopausal Depression: A Role of HPA Axis
https://pubmed.ncbi.nlm.nih.gov/37704445/
In a rat model of nicotine addiction, THC decreased self-administration
Experimenter administered Δ9-THC decreases nicotine self-administration in a rat model
https://www.sciencedirect.com/science/article/abs/pii/S0091305723001193
In female rats & mice, CBD lowered the panic response but only in certain phases of their estrous cycle
Sex and estrous cycle-linked differences in the effect of cannabidiol on panic-like responding in rats and mice
https://pubmed.ncbi.nlm.nih.gov/37703950/
On the neurophysiology of the complex cannabis- schizophrenia connection
The marijuana-schizophrenia multifaceted nexus: Connections and conundrums towards neurophysiology
https://pubmed.ncbi.nlm.nih.gov/37729848/
Against viruses, CBD has broad spectrum antiviral effects
Broad-Spectrum Antiviral Effect of Cannabidiol Against Enveloped and Nonenveloped Viruses
https://pubmed.ncbi.nlm.nih.gov/37682578/
And for the Lujo virus (which causes a severe hemorrhagic fever with high mortality), drugs that inhibit the CB1 receptor suppress the cellular entry of the virus
Inhibitors of cannabinoid receptor 1 suppress the cellular entry of Lujo virus
https://pubmed.ncbi.nlm.nih.gov/37633192/
A thesis project on how the cannabinoids modulate cocaine reinforcement in mice
Phytocannabinoids and endocannabinoids as modulators of cocaine reinforcement in mice
https://repositori.upf.edu/handle/10230/57859
An in-depth profiling of terpenes in different cultivars includes the discovery of 4 new terpenoids
Comprehensive Profiling of Terpenes and Terpenoids in Different Cannabis Strains Using GC × GC-TOFMS
https://www.mdpi.com/2297-8739/10/9/500
An AI platform for predicting drugs to bind to cannabinoid receptors named after a problematic minor Greek goddess
CIRCE: Web-Based Platform for the Prediction of Cannabinoid Receptor Ligands Using Explainable Machine Learning
https://pubmed.ncbi.nlm.nih.gov/37675493/
I mean the whole Odysseus thing was bad enough. But what went down with Glaucus & Scylla was cancel-worthy.
An evergreen note on reading restricted papers:
First stop for seeing if there’s a free version of a paper, use the Google Scholar Chrome extension (Mac version), Google Scholar itself or try ResearchGate.
Three other helpful browser extensions are: Unpaywall, Open Access Button & PaperPanda
For the infamous backdoor, use Sci-Hub – the pirated papers repository (Chrome extension here). This works better for older paper than the stuff that just came out.
Finally, email the author. They’re almost always happy to oblige because, thanks to the predatory academic publishing system, they don’t make a dollar off of their papers.
the Headlines & Fav Articles
The Air Force is offering triple of the expected number of waivers to recruits who used cannabis in the past
https://www.marijuanamoment.net/air-force-granted-triple-the-number-of-marijuana-waivers-it-expected-in-first-year-of-recruitment-policy-change/
Fly high kids, fly high.
The American Nurses Association recognizes cannabis as a nursing specialty practice area
https://www.marijuanamoment.net/american-nurses-association-officially-recognizes-cannabis-as-a-formal-specialty-practice-area/
A great list on the universities with cannabis programs by Dr. Simi Burn
Higher Learning: Accredited Universities Embrace Cannabis Education
https://medium.com/canna-convince/higher-learning-accredited-universities-embrace-cannabis-education-fc96845e795c
The USDA will allow a genetically modified hemp plant that produces no THC or CBC
https://www.marijuanamoment.net/usda-says-genetically-modified-hemp-plant-may-be-safely-grown-and-bred-in-the-united-states/
One of the best pieces of cannabis reporting I’ve seen in a long time: a Nepali cannabis activist, the Maoist rebels, the history of cannabis in the “Land of the Gods” & using cannabis for opiate addiction
https://harpers.org/archive/2023/10/purple-haze/
History Corner: The OG Alice O’Leary Randall on how a lexicographer called her to say that her husband coined the term “medical marijuana”
https://www.linkedin.com/posts/aliceolearyrandall_time-traveler-by-merriam-webster-activity-7116877210195517440-2v6w
International
A new report from Hanway on Europe’s blind spots around cannabis legalization
https://firstwednesdays.eu/social-impact
The War on Drugs & the End of Prohibition
An updated analysis of traffic fatalities & cannabis legalization finds either a small reduction in fatality rate or no change
Marijuana legalization and traffic fatalities revisited
https://onlinelibrary.wiley.com/doi/abs/10.1002/soej.12657
Business & Law
On the virtual monopoly of METRC & Colorado’s decision to do away with plant RFID tags
On the marketing & sales practices of cannabis retailers in five US cities
Assessment of Online Marketing and Sales Practices Among Recreational Cannabis Retailers in Five U.S. Cities
https://pubmed.ncbi.nlm.nih.gov/37699251/
A scoping review of medical cannabis & workplace health & safety
Medicinal Cannabis and Implications for Workplace Health and Safety: Scoping Review of Systematic Reviews
https://pubmed.ncbi.nlm.nih.gov/37632419/
(wish this wasn’t behind a paywall. looks fascinating)
On creating a digital twin of your cannabis production facility
A digital twin reference architecture for pharmaceutical cannabis production
https://www.tandfonline.com/doi/pdf/10.1080/0951192X.2023.2257635
In defense of piecemeal legislation for federal cannabis reform
Big Bills Are a Bust: Why Piecemeal Legislation is the Way to Go for Federal Cannabis Reform
https://www.albanygovernmentlawreview.org/article/87835-big-bills-are-a-bust-why-piecemeal-legislation-is-the-way-to-go-for-federal-cannabis-reform
Psychedelics, Plant Medicines & Other Psychoactives
In the first episode of the new Federal Veterans Affairs podcast, they focus on psychedelics
https://www.marijuanamoment.net/first-episode-of-new-federal-veterans-affairs-podcast-focuses-on-psychedelics-healing-potential/
Case reports of psychedelics reversing aphantasia (a lack of internal imagery)
https://psyche.co/ideas/psychedelics-could-give-a-minds-eye-to-those-whove-never-had-one
An excellent essay on folklore & psychedelics to introduce the last print issue of the Psychedelic Press
An Introduction to Folklore and Psychedelics
A history of psychedelics in France
History of the administration of psychedelics in France
https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1131565/full
A great podcast interview psychedelic humanities with Dr. Oliver Davis (author of the recently highlighted manifesto on the psychedelic side of Henri Michaux)
Psychedelic politics and humanities
https://www.musingmind.org/podcasts/psychedelic-therapy-politics-humanities-renaissance-oliver-davis
On Hawaiian baby woodrose seeds (a source of LSA & one of my fondest early trips)
Reader’s Digest on the psychedelic playlist
https://www.readersdigest.co.uk/inspire/the-hunt-for-the-perfect-psychedelic-playlist
The Psychoactive Research
[This isn’t a deep dive into the science of psychedelics & other psychoactives like I do for the cannabinoids. If your organization would be interested in a breakdown of all the new psychedelic science, reach out to me]
On psychedelics & AI as inequality engines by Dr. Neşe Devenot
TESCREAL hallucinations: Psychedelic and AI hype as inequality engines
https://akjournals.com/view/journals/2054/aop/article-10.1556-2054.2023.00292/article-10.1556-2054.2023.00292.xml
In healthy humans, psilocybin reduced pro-inflammatory cytokines
Psilocybin induces acute and persisting alterations in immune status in healthy volunteers: An experimental, placebo-controlled study
https://pubmed.ncbi.nlm.nih.gov/37689275/
A microdosing study found no impact on neurocognitive functions
Microdosing psychedelics has no impact on cognitive function in naturalistic settings
https://www.researchgate.net/publication/373019485_Microdosing_psychedelics_has_no_impact_on_cognitive_function_in_naturalistic_settings
Esketamine nasal spray found helpful for treatment resistant depression
Efficacy and Safety of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Who Completed a Second Induction Period: Analysis of the Ongoing SUSTAIN-3 Study
https://pubmed.ncbi.nlm.nih.gov/37558912/
A survey on entheogenic spirituality
Entheogens and spiritual seeking: The quest for self-transcendence, psychological well-being, and psychospiritual growth
https://akjournals.com/view/journals/2054/7/1/article-p69.xml
A survey on how most psychedelic users don't tell their healthcare providers
Slouching towards engagement: interactions between people using psychedelics naturalistically and their healthcare providers
https://pubmed.ncbi.nlm.nih.gov/37599880/
The Plant & the History
Growing & Farming
First reports of the bacterium Spiroplasma citri in hemp of the Pacific Northwest
First report of Spiroplasma citri associated with disease symptoms in field-grown hemp (Cannabis sativa L.) in the Pacific Northwest
https://apsjournals.apsnet.org/doi/pdf/10.1094/PDIS-07-23-1419-PDN
For southern blight disease caused by the fungal pathogen Athelia rolfsii in hydroponic systems, pretreatment with chitosan increased plant defenses but decreased roots
Hormonal and proteomic analyses of southern blight disease caused by Athelia rolfsii and root chitosan priming on Cannabis sativa in an in vitro hydroponic system
https://pubmed.ncbi.nlm.nih.gov/37692128/
A thesis project covering several years of lessons on growing hemp in the mid-Atlantic region
Industrial hemp agronomic management for grain, fiber, and forage
https://vtechworks.lib.vt.edu/handle/10919/116272
How to extract cannabis under cryogenic conditions
Solvent extraction of Cannabis sativa under cryogenic conditions
https://www.sciencedirect.com/science/article/abs/pii/S1383586623018142
On using chromatography to remediate hemp extracts
Evaluation of advanced liquid–liquid chromatography operating modes for the tetrahydrocannabinol-remediation of hemp extracts
https://www.sciencedirect.com/science/article/abs/pii/S0009250923008357
Hemp as food
An analysis of hemp proteins
The in vivo and in vitro protein quality of three hemp protein sources
https://onlinelibrary.wiley.com/doi/pdf/10.1002/fsn3.3652
In lactating cows, a study supporting feeding them spent hemp biomass
Feeding spent hemp biomass to lactating dairy cows: effects on performance, milk components and quality, blood parameters, and nitrogen metabolism
https://pubmed.ncbi.nlm.nih.gov/37690708/
Industrial Use
Using hemp to remediate the Tar Creek Superfund site
Evaluation of Biochar Rate and Hemp Cultivar to Remediate Heavy-Metal-Contaminated Soil From the Tar Creek Superfund Site
https://www.proquest.com/openview/97dc1ea163df58db95bfa9a5d3383453/1?pq-origsite=gscholar&cbl=18750&diss=y
Hemp fiber as antibacterial fruit packaging
Electrospun polylactic acid nanofiber film modified by silver oxide deposited on hemp fibers for antibacterial fruit packaging
https://pubmed.ncbi.nlm.nih.gov/37648140/
Using the microbes in cow stomachs for turning hemp into biogas
Anaerobic Digestion of Hemp and Flax Straw and Shives and Rapeseed Straw by the Ruminal Microbiota
https://link.springer.com/article/10.1007/s12155-023-10667-7
CANNABINOID SCIENCE
A unique review of cannabis research at the biopsychosocial level
Evolution of Marijuana Research at the Biopsychosocial Level: a General View
https://link.springer.com/article/10.1007/s11469-023-01129-4
Clinical Use, Surveys & Ingestions Methods
Adolescents & Young People
In public health data on children presenting with cannabis poisonings, the researchers stated that more ancillary testing should be done because cases are on the rise
Resource utilization among children presenting with cannabis poisonings in the emergency department, a retrospective analysis
https://pubmed.ncbi.nlm.nih.gov/37696075/
Using public health data, females who used cannabis during adolescence had a significant increase in anxiety
The long-term effects of marijuana use on mental health outcomes
https://link.springer.com/article/10.1007/s11150-023-09680-8
Among college students, a better predictor of risk for cannabis use disorder was flower potency, not quantity or within day use
Examining Associations Between Cannabis Use Disorder and Measures of Weekly and Within-Day Cannabis Frequency, Quantity, and Potency in College Students
https://pubmed.ncbi.nlm.nih.gov/37699241/
A new test for cannabis use disorder among young adults
Screening for cannabis use disorder among young adults: Sensitivity, specificity, and item-level performance of the Cannabis Use Disorders Identification Test – Revised
https://pubmed.ncbi.nlm.nih.gov/37717499/
In young mice exposed to lead, only the females showed an increased sensitivity to THC
Impact of early-life lead exposure on adult delta-9-tetrahydrocannabinol sensitivity in male and female C57BL6/J mice
https://pubmed.ncbi.nlm.nih.gov/37690674/
Neurology & Brain Diseases
In neurons, CBC, CBG & CBN inhibited neurotoxicity from the beta amyloid plaques of Alzheimer’s
The structurally diverse phytocannabinoids cannabichromene, cannabigerol and cannabinol significantly inhibit amyloid β-evoked neurotoxicity and changes in cell morphology in PC12 cells
https://pubmed.ncbi.nlm.nih.gov/37697481/
For multiple sclerosis, a computer study of how cannabis constituents interact with epigenetic targets
Computational study of interactions of Cannabis Sativa constituents with potential epigenetic targets involved in processes of multiple sclerosis
https://farfar.pharmacy.bg.ac.rs/handle/123456789/5012
In a mouse model of Alzheimer's disease, PEA helped counteract dysfunctions of the mitochondria (cellular power center) in the frontal cortex but not in the more affected hippocampus
Effects of Ultramicronized Palmitoylethanolamide on Mitochondrial Bioenergetics, Cerebral Metabolism, and Glutamatergic Transmission: An Integrated Approach in a Triple Transgenic Mouse Model of Alzheimer's Disease
https://pubmed.ncbi.nlm.nih.gov/35686025/
In a rat model of Alzheimer's disease, a drug that blocked the CB1 receptor increased their spatial memory
Cannabinoid Type 1 Receptor Antagonist Impaired Spatial Memory and Increased the Tau Gene Expression in Animal Model of the Alzheimer's Disease
https://assets.researchsquare.com/files/rs-3332329/v1/bb063dda-b172-4bb2-8cc0-ab8f968b71fe.pdf?c=1695147743
In a mouse model of Alzheimer's disease, the glial (immune cells) altered the pathology with cannabinoid signaling playing an important role, plus gender differences
Sex-Dependent Altered Expression of Cannabinoid Signaling in Hippocampal Astrocytes of the Triple Transgenic Mouse Model of Alzheimer's Disease: Implications for Controlling Astroglial Activity
https://pubmed.ncbi.nlm.nih.gov/37628778/
In neuronal cells, delta-8 THC counteracted a traumatic event & protected them from cell death, probably via the Janus Kinase Signal Transducer & Activator of Transcription (JAK/STAT) & the Mitogen-Activated Protein (MAP)
Transcriptomic Profiling after In Vitro Δ8-THC Exposure Shows Cytoskeletal Remodeling in Trauma-Injured NSC-34 Cell Line
https://pubmed.ncbi.nlm.nih.gov/37765076/
In mouse motor synapses, 2-AG increased acetylcholine activation
Quantal size increase induced by the endocannabinoid 2-arachidonoylglycerol requires activation of CGRP receptors in mouse motor synapses
https://pubmed.ncbi.nlm.nih.gov/37694983/
GAP43 is a drug that blocks the CB1 receptor, but not via the usual signaling pathway but by another that relates to excitation in the hippocampus (of relevance to epilepsy)
Selective inhibition of cannabinoid CB1 receptor-evoked signalling by the interacting protein GAP43
https://www.sciencedirect.com/science/article/pii/S0028390823003027
Mental Health & Substance Use Disorders
For PTSD, a small trial of vaporized cannabis saw positive changes
A small clinical trial of vaporized cannabis for PTSD: suggestive results and directions for future study
https://pubmed.ncbi.nlm.nih.gov/37689680/
On the relationship between adverse childhood experiences, social-emotional impairments & neurodevelopmental disorders in individuals with cannabis use disorder
A comprehensive evaluation of adverse childhood experiences, social-emotional impairments, and neurodevelopmental disorders in cannabis-use disorder: Implications for clinical practice
https://pubmed.ncbi.nlm.nih.gov/37702087/
And a thesis project on childhood maltreatment & endocannabinoid function
Impact of Childhood Maltreatment and Endocannabinoid Function on Posttraumatic Stress Symptoms in Traumatically-Injured Adults
https://www.proquest.com/openview/8760310fedb7bbe1ec88971fa3354ef8/1?pq-origsite=gscholar&cbl=18750&diss=y
In people with major depression & suicidal behaviors, they had altered cannabinoid receptor levels on their T cells & B cells
Role of T and B lymphocyte cannabinoid type 1 and 2 receptors in major depression and suicidal behaviors
https://pubmed.ncbi.nlm.nih.gov/37681553/
An analysis of public health data on the characteristics of those with cannabis use disorder
Characterizing Marijuana Use Disorders (DSM-5) — National Survey on Drug Use and Health, United States, 2020
https://link.springer.com/article/10.1007/s11469-023-01137-4
This group says they can use AI & brain scans to predict which patients are “cannabis addictive
Prediction of Cannabis Addictive Patients with Graph Neural Networks
https://link.springer.com/chapter/10.1007/978-3-031-43075-6_26
In a rat model of anxiety, a 1:100 THC:CBD edible reduced anxiety & depression in male rats only, and in most cases the combination of THC & CBD had stronger effects than either cannabinoid alone
Sex-Dependent Synergism of an Edible THC: CBD Formulation in Reducing Anxiety and Depressive-like Symptoms Following Chronic Stress
https://pubmed.ncbi.nlm.nih.gov/37702237/
Female-specific, Reproduction & Hormones
In adolescent rats exposed to alcohol & THC, they had alterations to the synaptic plasticity in their prefrontal cortex as well as food intake changes
Effects of combined exposure to ethanol and delta-9-tetrahydrocannabinol during adolescence on synaptic plasticity in the prefrontal cortex of Long Evans rats
https://pubmed.ncbi.nlm.nih.gov/37645740/
A thesis project on prenatal THC exposure causing lasting negative effects on the hippocampus of rats
Prenatal THC exposure has lasting detrimental effects on the rat hippocampus
http://dspace.library.uvic.ca/bitstream/handle/1828/15376/Reid_Hannah_PhD_2023.pdf?sequence=3&isAllowed=y
And a thesis project on the negative effects of THC on sperm
The Impact of THC on Developmental Parameters, Fertilization Capability, Epigenetic Modification in Sperm and Embryos Produced In Vitro with THC-Exposed Sperm
https://atrium.lib.uoguelph.ca/items/3b951d51-2ecd-4e69-9f0b-b14dce981e61
In a mouse model of gestational obesity, a nutritional intervention helped to, among other things, normalize liver endocannabinoid levels
Effects on Fetal Metabolic Programming and Endocannabinoid System of a Normocaloric Diet during Pregnancy and Lactation of Female Mice with Pregestational Obesity
https://pubmed.ncbi.nlm.nih.gov/37630722/
In rats, reproduction controlled by an interplay between the endocannabinoid system & the kisspeptin system
The interplay between Kisspeptin and endocannabinoid systems modulates male hypothalamic and gonadic control of reproduction in vivo
https://www.frontiersin.org/articles/10.3389/fendo.2023.1269334/abstract
Pain, Inflammation & Surgeries
In facial surgeries, cannabis users require more anesthetic
Cannabis Users Require More Anesthetic Agents for General Anesthesia in Ambulatory Oral and Maxillofacial Surgery Procedures
https://pubmed.ncbi.nlm.nih.gov/37783364/
After ACL reconstruction surgery, cannabis use disorder was not associated with a change in patient reported outcomes or opioid usage
Cannabis Use Disorder Not Associated With Opioid Analgesic Use or Patient-Reported Outcomes After ACL Reconstruction: A Retrospective Matched-Cohort Analysis
https://pubmed.ncbi.nlm.nih.gov/37632361/
In patients with ankle fractures, cannabis users had no greater risk of adverse events in the following three months, though those who used tobacco with cannabis did
Adverse Events After Ankle Fracture Open Reduction Internal Fixation Among Patients With and Without Documented Cannabis and Tobacco Use
https://pubmed.ncbi.nlm.nih.gov/37698277/
A review of 15 studies isn't sure if cannabinoids lower the use of opioids
Dosing of Cannabinoids Associated with an Opioid-Sparing Effect: A Systematic Review of Longitudinal Studies
https://pubmed.ncbi.nlm.nih.gov/37689509/
A review of cannabis for chronic pain
Systematic review on the effectiveness of medical cannabis for the treatment of chronic pain
https://www.um.edu.mt/library/oar/handle/123456789/112884
The lignanamides isolated from hemp seed hulls inhibited soluble epoxide hydrolases (a therapeutic target for inflammation)
Inhibitory activity of lignanamides isolated from hemp seed hulls(Cannabis sativa L.) against soluble epoxide hydrolase
https://www.sciencedirect.com/science/article/pii/S2405844023069803
The Immune System
In a murine model of graft versus host disease, blocking the CB2 receptors on the microglia immune cells reduced neuroinflammation
MICROGLIAL CELL EXPRESSION OF THE TYPE 2 CANNABINOID RECEPTOR REGULATES IMMUNE-MEDIATED NEUROINFLAMMATION
https://pubmed.ncbi.nlm.nih.gov/37645843/
The Guts, Oral Health & CHS
On two atypical cases of cannabinoid hyperemesis syndrome
Atypical Presentation of Cannabinoid Hyperemesis Syndrome: Two Case Reports
https://www.endocannabinoidmedicine.com/academicarticle/atypical-presentation-of-cannabinoid-hyperemesis-syndrome/?hmemail=&sha256email=a231fb714e42f4afd688e711772af2c4a3f34dcce39af6321588762cdd0485dc&hmsubid=&nid=&elqtrack=True
A case series of treating adolescents with cannabinoid hyperemesis syndrome
Acute Treatment of Adolescent Cannabinoid Hyperemesis Syndrome With Haloperidol, Lorazepam, and/or Capsaicin: A Single Institution Case Series
https://pubmed.ncbi.nlm.nih.gov/37678364/
The Heart
In young men, a high proportion of patients with adult congenital heart diseases also used cannabis
Cannabis Use: A New Risk Behaviour Among Adults With Congenital Heart Disease
https://www.sciencedirect.com/science/article/pii/S2772812923001252
The terpene eugenol protects guinea pigs from cardiac arrhythmias
Eugenol delays the onset of ouabain-induced ventricular cardiac arrhythmias in guinea pigs
https://onlinelibrary.wiley.com/doi/abs/10.1111/bcpt.13941
The Lungs
Two cannabis users with pneumomediastinum (air in the chest cavity)
Spontaneous Pneumomediastinum in Marijuana Users
https://assets.cureus.com/uploads/case_report/pdf/172819/20230911-26511-1aztt61.pdf
The Genitourinary System
On using endocannabinoid levels as a biomarker to distinguish interstitial cystitis/bladder pain syndrome from overactive bladder
Serum anandamide and lipids associated with linoleic acid can distinguish interstitial cystitis/bladder pain syndrome from overactive bladder: An exploratory study
https://pubmed.ncbi.nlm.nih.gov/37688290/
In a mouse model of nocturia (a nighttime need to urinate), a loss of circadian rhythm may cause higher blood levels of PEA, which then bind to GPR55 & activate the downstream processes of the urination reflex
G protein-coupled receptor 55 activated by palmitoylethanolamide is associated with the development of nocturia associated with circadian rhythm disorders
https://pubmed.ncbi.nlm.nih.gov/37704067/
Cancer & Chemotherapy
In patients who had undergone pancreatic cancer surgery, those with higher levels of CB2 receptors had a greater length of survival
Morphine Analgesia, Cannabinoid Receptor 2, and Opioid Growth Factor Receptor Cancer Tissue Expression Improve Survival after Pancreatic Cancer Surgery
https://pubmed.ncbi.nlm.nih.gov/37627066/
In patients with papillary thyroid carcinoma (the most common cancer of the endocrine system), the expression level of CB1 & CB2 receptors were significantly higher in the cancer patients versus those with benign thyroid lesions
The clinical and pathological significance of increased expression of the cannabinoid receptors CB-1R and CB-2R in patients with papillary thyroid carcinomas compared to benign thyroid lesions
https://pubmed.ncbi.nlm.nih.gov/37700679/
In children with cancer, on using cannabinoids for symptom management
Cannabinoids for symptom management in children with cancer: It's complicated
https://pubmed.ncbi.nlm.nih.gov/37641180/
In prostate cancer cells, CBD inhibited proliferation & invasiveness
Cannabidiol Inhibits the Proliferation and Invasiveness of Prostate Cancer Cells
https://pubmed.ncbi.nlm.nih.gov/37703852/
In glioblastoma cells (the most aggressive brain cancer), a combination of CBD & etoricoxib (a COX-2 inhibitor) reduced cell viability & increased apoptosis (cellular suicide)
Etoricoxib-Cannabidiol Combo: Potential Role in Glioblastoma Treatment and Development of PLGA-Based Nanoparticles
https://pubmed.ncbi.nlm.nih.gov/37631318/
Synthetic Cannabinoids
The synthetic cannabinoid AKB48 caused changes that varied greatly by gender
Sex-specific behavioural, metabolic and immunohistochemical changes after repeated administration of the synthetic cannabinoid AKB48 in mice
https://europepmc.org/article/ppr/ppr722145
Cool Chemistry
A new bioluminescent sensor for profiling compounds at cannabinoid receptors
Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors
https://pubmed.ncbi.nlm.nih.gov/37637423/
On better nanocarriers for CBD
Cinnamyl-Modified Polyglycidol/Poly(ε-Caprolactone) Block Copolymer Nanocarriers for Enhanced Encapsulation and Prolonged Release of Cannabidiol
https://pubmed.ncbi.nlm.nih.gov/37631342/
Thanks.
- lex
PS: For this week’s swell old tunes, Sweet Emma Barrett’s album ‘Her New Orleans Music’. A self-taught pianist & singer, she grew up in New Orleans & started playing jazz in the ‘20s with the Original Tuxedo Orchestra. Despite international recognition, she still felt most at home in New Orleans & by the ‘60s, she was recording with most of the members who went on to form the Preservation Hall Jazz Band. Despite a stroke & other ills, she continued playing music until her death at the age of 85.
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