C&P#76: cannabis stimulant abuse + CBD & breastfeeding + lovely terpene chart
Health insurance won’t payout because of unreported cannabis use
Hello everyone,
Welcome to the 76th edition of Cannabinoids & the People, a weekly newsletter where I collect all the new cannabinoid science. You can check out last week’s issue here & if you haven’t subscribed yet, please do. Sign up for a paid subscription to support my work disseminating all of the cannabinoid science.
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Announcements
This newsletter will be off next week for family time.
This week, the audio of my recent lecture was released as well as a book chapter on CBD that I co-authored.
Also, perhaps my greatest LinkedIn post of all time dropped thru the algo with nary a view…
(do you get the reference?)
This week…
Cannabis for stimulant use disorder
The French think their medical cannabis pilot program was a success (Mais oui!)
Breastfeeding study shows minimal CBD exposure for infants
Cannflavins for autism, cannflavins for life
A new drug for reversing cannabinoid intoxication
A beautiful terpene chart
To get teens to stop blazing, get them in volunteer programs I guess
Hemp as a cover crop in your vineyards: cannabis soaked in wine, the Dionysian way!
For couples connecting, MDMA & meth
A request to spread the word
This newsletter only spreads by word of mouth,
so please forward to colleagues & tell your friends & relatives.
Sponsor: PlusCBD & a commitment to quality
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My work this week:
Talks & book chapters:
The audio of my talk from CBExpo in Germany (Spotify or Apple):
‘Cannabinoids & Terpenes - A Plethora of Potential Products to Produce’
And the release of the Health Professional’s Guide to Dietary Supplements where I co-authored the CBD chapter.
My news article for the American Journal of Endocannabinoid Medicine:
Psychedelics Pioneer Roland Griffiths, PhD, Loses Battle With Colon Cancer
Medical Cannabis Driving Trial Set To Launch in Australia
Cholinergic Circuits Are Promising New Area of Research for Non-Opioid Pain Control
Canna-Education for CV Sciences
(TikTok:@cvsciences or my YouTube playlist 3-minute Cannabinoid Science):
CBD & Alcohol Use Disorder
Cannabinoids & Bipolar
Cannabinoids & Panic Attack (1 joke)
Less Psychoactivity for Medical Patients (10k views)
Cannabis, Lactation & Breastfeeding
The Herb & Unsuppressing a Memory
My TikToks (@lexpelgerandhisbooks or on YouTube):
Top Shelf Wisdom Books: The Mahabharata
Top Shelf Wisdom Books: Tibetan Yoga & Secret Doctrines by WY Evans-Wentz
Mead's Hermetica & Longfellow's 'Hermes Trismegistus'
Bruno as Autistic Memory Man
Why I Think About the Roman Empire: 4 Books (one Hogan’s Heroes reference for my dad)
Astrology Classical Music: Holst's The Planets
Sciencemancy: Autism & ADHD, Genomics & Plastic Additives
Sciencemancy: Superposition of Quantum Phonons
My platforms: Linktree
YouTube for educational videos, lectures & shorts on new cannabinoid science
Anandamide; or, the People: my graphic novel series on cannabis, the endocannabinoid system & the War on Drugs based on Moby-Dick
My podcasts
LinkedIn & Twitter & my TikTok on books, hermeticism, science & history
Ways to support this work:
Subscribe on Substack
Buy Me a Coffee
Venmo: @Lex-Pelger
PayPal: donate here
Best Of Cannabinoid Science...
On the ECS & the mind-body connection by Dr. Ruth Fisher
The Role of the Endocannabinoid System (ECS) in the Mind-Body Connection
https://www.cannapatientcare.com/view/the-role-of-the-endocannabinoid-system-ecs-in-the-mind-body-connection
On the advantages of full plant extracts
Medicinal cannabis: Would using the plant have advantages over using the individual ingredients?
https://www.fundacion-canna.es/en/medicinal-cannabis-would-using-plant-have-advantages-over-using-individual-ingredients
Clinical
In a survey of people who use stimulants, half of them used cannabis to manage their cravings
Cannabis use to manage stimulant cravings among people who use unregulated drugs
https://pubmed.ncbi.nlm.nih.gov/37748225/
A survey of orthopedic sports medicine providers find that most support the use of CBD for pain management
Perceptions and Opinions on Cannabidiol in the Orthopaedic Sports Medicine Community
https://journals.sagepub.com/doi/full/10.1177/23259671231191766
A small study shows similar absorption effects from sublingual drops of CBD versus gelatin capsules
Cannabidiol Oil Ingested as Sublingual Drops or Within Gelatin Capsules Shows Similar Pharmacokinetic Profiles in Healthy Males
https://pubmed.ncbi.nlm.nih.gov/37733294/
On using the CB1 antagonist ANEB-001 to reverse THC effects in healthy subjects
Randomized Controlled Trial of ANEB-001 as an Antidote for Acute Cannabinoid Intoxication in Healthy Adults
https://www.annemergmed.com/article/S0196-0644(23)00986-1/fulltext
And in the emergency room to reverse acute cannabinoid intoxication
Prediction of a Therapeutically Active Dose of the Cannabinoid Type 1 Receptor Antagonist ANEB-001 for Reversal of Acute Cannabis Intoxication Using a Pharmacokinetic/Pharmacodynamic Model
https://www.annemergmed.com/article/S0196-0644(23)01066-1/fulltext
How your diet affects your microbiome & endocannabinoidome
Dietary food patterns as determinants of the gut microbiome-endocannabinoidome axis in humans
https://pubmed.ncbi.nlm.nih.gov/37735572/
“N-acyl-ethanolamines (NAEs) and gut microbial families were correlated with intakes of vegetables, refined grains, olive oil and meats independently of adiposity and energy intakes. Specifically, higher intakes in vegetables and olive oil were associated with increased relative abundance of Clostridiaceae, Veillonellaceae and Peptostreptococaceae, decreased relative abundance of Acidominococaceae, higher circulating levels of NAEs, and higher HDL and LDL cholesterol levels.”
Between sexual orientation groups, the differences in perceptions of cannabis risks
Disparities in cannabis use outcomes, perceived risks and social norms across sexual orientation groups of US young adult women and men
https://pubmed.ncbi.nlm.nih.gov/37756620/
Based on real-world breastfeeding data, using CBD causes an exposure to breastfed infants “magnitudes lower than exposures in children aged 4–11 years administered the lowest therapeutic dose for approved indications”
Cannabidiol Exposure Through Maternal Marijuana Use: Predictions in Breastfed Infants
https://link.springer.com/article/10.1007/s40262-023-01307-6
A thesis project on women using cannabis for menstrual cycle distress
Cannabis Use Among Women Experiencing Menstrual Cycle Distress
https://knowledgecommons.lakeheadu.ca/bitstream/handle/2453/5233/SheininM2023m-1a.pdf?sequence=1&isAllowed=y
A thesis project reports THC helped with delayed-onset muscle soreness after intense exercise
THE EFFECT OF DELTA-9-TETRAHYDROCANNABINOL ON DELAYED-ONSET MUSCLE SORENESS
https://repository.arizona.edu/handle/10150/668711
A case report of catastrophic lung effects from using a bucket bong
Case Report: Catastrophic Effects of Using Cannabis Via Bucket Bong in Top End Northern Territory of Australia
https://pubmed.ncbi.nlm.nih.gov/37696516/
In cats with gingivostomatitis (severe inflammatory gum infection), a placebo-controlled study found that 15 days of CBD (4 mg/kg) twice a day significantly improved disease scores
Placebo-Controlled Trial of Daily Oral Cannabidiol as Adjunctive Treatment for Cats with Chronic Gingivostomatitis
https://pubmed.ncbi.nlm.nih.gov/37684980/
Reviews
A great callback review paper on the effects of cannabinoids on the electrome (our body & mind’s bioelectricity), a prevailing view of the ‘80s that was neglected after the discovery of the cannabinoid receptors (great charts! – and here’s that LinkedIn post again)
Informing the Cannabis Conjecture: From Life's Beginnings to Mitochondria, Membranes and the Electrome-A Review
https://pubmed.ncbi.nlm.nih.gov/37685877/
On using cannabinoids for chronic neuropathic pain
Cannabis constituents for chronic neuropathic pain; reconciling the clinical and animal evidence
https://pubmed.ncbi.nlm.nih.gov/37747128/
And a review of how the endocannabinoid system helps with neuroinflammation (great charts!)
Neuroinflammation in the Central Nervous System: Exploring the Evolving Influence of Endocannabinoid System
https://www.mdpi.com/2227-9059/11/10/2642
On using CBD for aging, especially Alzheimer's disease
The Main Therapeutic Applications of Cannabidiol (CBD) and Its Potential Effects on Aging with Respect to Alzheimer’s Disease
https://www.mdpi.com/2218-273X/13/10/1446
And on the use of medical cannabis by older adults
Medical Cannabis Use and Its Impact on Health Among Older Adults: Recent Research Findings and Future Directions
https://link.springer.com/article/10.1007/s40429-023-00519-x
For brain hemorrhages, a review of the benefits of CBD & its antioxidant effects
Anti-oxidant effects of cannabidiol relevant to intracerebral hemorrhage
https://pubmed.ncbi.nlm.nih.gov/37841923/
A review of 12 studies on the benefits of using CBD in sunscreen
Cannabidiol in Sunscreen: A Survey of Current Peer-Reviewed Evidence
https://www.jaad.org/article/S0190-9622(23)01885-6/fulltext
A review confirms the conventional wisdom: CBD & THC don't cause drug interactions with the anticoagulants except for warfarin (which apparently is a touchy drug that seems to get interfered with by everything)
Anticoagulant drug-drug interactions with cannabinoids: A systematic review
https://pubmed.ncbi.nlm.nih.gov/37740600/
And a review on the lesser-covered topic of drug interactions with hemp seed oil
The Impact of Hemp Seed Oil on Drug-Drug Interactions: A Comprehensive Review of Potential Mechanisms and Clinical Implications
https://assets.researchsquare.com/files/rs-3376948/v1/13903e2a-f45d-4c00-bd45-164228b3bf93.pdf?c=1695614867
A review of the effects of the cannflavins
Chemistry and Biological Activities of Cannflavins of the Cannabis Plant
https://pubmed.ncbi.nlm.nih.gov/37756221/
A review of the importance of the arachidonic acid family (which includes anandamide)
Arachidonic acid metabolism in health and disease
https://pubmed.ncbi.nlm.nih.gov/37746665/
And a related study on the metabolic importance of the related lipid NAPE-PLD
NAPE-PLD in the ventral tegmental area regulates reward events, feeding and energy homeostasis
https://assets.researchsquare.com/files/rs-3199777/v1/3456f761-b36b-4f57-881b-1cd80fd61cd0.pdf?c=1696959461
Preclinical
In a rat model of type 2 diabetes, the helpful effects of the terpene beta caryophyllene
Hypolipidemic effect of β-caryophyllene in high fat diet and fructose induced type-2 diabetic adult male rats
https://pubmed.ncbi.nlm.nih.gov/37693084/
A thesis project on using CBD for dental pain
Cannabidiol (CBD) for Dental Pain
https://www.proquest.com/openview/99436092e2ef6e896d145863c65f2944/1?pq-origsite=gscholar&cbl=18750&diss=y
A thesis project in neurons on using cannflavins for autism
Evaluating the Therapeutic Effects of Cannflavins on Hippocampal Neuronal Systems Function in the Valproic Acid Model of Autism Spectrum Disorder
https://atrium.lib.uoguelph.ca/items/830fa9d2-8b96-420e-bd63-327c348e248f
In rabbits, how the postmortem levels of THC change after death depending on time & temperature
Time- and temperature-dependent postmortem ∆9-tetrahydrocannabinol concentration changes in rabbits following controlled inhaled cannabis administration
https://academic.oup.com/jat/advance-article-abstract/doi/10.1093/jat/bkad076/7284237?redirectedFrom=fulltext
How CBGA is synthesized & its role in medicine
Biosynthetic Pathway and Medical Role of Cannabigerolic Acid
https://www.saspublishers.com/media/articles/SJET_119_187-190.pdf
An evergreen note on reading restricted papers:
First stop for seeing if there’s a free version of a paper, use the Google Scholar Chrome extension (Mac version), Google Scholar itself or try ResearchGate.
Three other helpful browser extensions are: Unpaywall, Open Access Button & PaperPanda
For the infamous backdoor, use Sci-Hub – the pirated papers repository (Chrome extension here). This works better for older paper than the stuff that just came out.
Finally, email the author. They’re almost always happy to oblige because, thanks to the predatory academic publishing system, they don’t make a dollar off of their papers.
the Headlines & Fav Articles
Tara Eveland analyses the public information on CANNRA - the Cannabis Regulators Association
A New Jersey poll showed that people believe their right to consume cannabis at home outweighs their neighbor’s right to not smell it
https://www.marijuanamoment.net/new-jersey-residents-say-right-to-use-marijuana-at-home-outweighs-right-not-to-smell-neighbors-use-poll-shows/
This one is quite a tricky question. For some people, the smell of cannabis is nauseating or allergy-inducing. But for many medical patients, there’s no safe place to consume besides their home.
The health insurance company Transamerica is refusing to pay the death benefits for someone’s mother because she hadn’t mentioned occasional cannabis use on her application form
https://www.thinkadvisor.com/2023/10/12/transamerica-sued-over-marijuana-linked-claim-denial/
On the changes of the framing of cannabis in Black newspapers
The Framing of Marijuana in Black Newspapers∗
https://burrelvannjr.com/docs/vannjr_2023.pdf
On cannabinoids spreading across the veterinary realms
https://news.vin.com/default.aspx?Id=11720176&f5=1&pid=210
International
An analysis of the French medical cannabis experiment is positive (and in this Land of No, that’s saying something)
Cannabis médical : retour sur l’expérimentation française
https://www.sciencedirect.com/science/article/abs/pii/S2352007823001786
But an analysis of cannabis & driving found an increased risk
Cannabis à usage médical et conduite automobile
https://www.sciencedirect.com/science/article/abs/pii/S2352007823002354
and a secret buyer study of CBD products in France finds that while most are safe & below the legal limit of THC, the majority are under-labeled for CBD content
Cannabidiol (CBD) : analyse de produits « CBD non pharmaceutiques » disponibles en France
https://www.sciencedirect.com/science/article/abs/pii/S2352007823001798
Ireland’s first medical cannabis facility set to open next year
https://www.thejournal.ie/islands-first-medical-cannabis-production-facility-to-open-next-year-6195645-Oct2023/
The War on Drugs & the End of Prohibition
According to the FBI, cannabis still accounts for a third of all drug arrests
https://www.marijuanamoment.net/fbi-report-says-3-in-10-drug-arrests-are-for-marijuana-but-agencys-inconsistent-data-hinders-policy-analysis/
The Sinaloa Cartel orders its members to stop making fentanyl because of the increased pressure from US law enforcement
https://www.wsj.com/world/americas/mexican-sinaloa-cartels-message-to-members-stop-making-fentanyl-or-die-b96d3e09
On the ease of minors to access cannabis via online dispensaries
Access to Marijuana by Minors Via Online Dispensaries
https://pubmed.ncbi.nlm.nih.gov/37747718/
Business & Law
Protectionists cannabis companies in California sue their rivals who are making THC products derived from hemp
https://mjbizdaily.com/california-marijuana-operators-sue-rivals-selling-hemp-derived-thc-products/
Mailchimp bans the newsletter of Heady’s NJ, a small independent cannabis media company
https://headynj.com/mailchimp-bans-heady-njs-newsletter-the-heady-chronicle/
Psychedelics, Plant Medicines & Other Psychoactives
Great psychedelic newsletter: From Josh Hardman of Psychedelic Alpha (who is excellent on gathering the science), a great new one-stop newsletter for all your psychedelic news:
https://psychedelicalpha.com/live
If you only had time for one psychedelic newsletter, this is the one I would recommend.
On the current underground party drugs & the future of sober-ish partying with Michelle Lhooq
On STP, the danger drug of the Summer of Love
Learning about STP
A Forgotten Psychedelic from the Summer of Love
https://hopp.uwpress.org/content/65/1/93
The Psychoactive Research
[This isn’t a deep dive into the science of psychedelics & other psychoactives like I do for the cannabinoids. If your organization would be interested in a breakdown of all the new psychedelic science, reach out to me]
On an Indigenous pilot program of the group use of psychedelic doses of ketamine
Indigenous Voices in Psychedelic Therapy: Experiential Learnings from a Community-Based Group Psychedelic Therapy Program
https://pubmed.ncbi.nlm.nih.gov/37723666/
And analyzing the effects of ayahuasca in neo-shamanic & religious settings
Ayahuasca, Personality and Acute Psychological Effects in Neo-Shamanic and Religious Settings in Uruguay
https://www.tandfonline.com/doi/abs/10.1080/02791072.2023.2261017
The best way to predict your chances of having a mystic is psychedelic experience is… dose
Predicting the Intensity of Psychedelic-Induced Mystical and Challenging Experience in a Healthy Population: An Exploratory Post-Hoc Analysis
https://pubmed.ncbi.nlm.nih.gov/37818448/
For partners, the increased connections from both MDMA & methamphetamine
Drug-induced social connection: both MDMA and methamphetamine increase feelings of connectedness during controlled dyadic conversations
https://pubmed.ncbi.nlm.nih.gov/37740024/
On the experience of shame & guilt during & after psilocybin use
Shame, guilt and psychedelic experience: Results from a prospective, longitudinal survey of real-world psilocybin use
https://osf.io/preprints/psyarxiv/hm6jn/
How psilocybin changes in brain blood flow
Psilocybin-induced changes in cerebral blood flow are associated with acute and baseline inter-individual differences
https://pubmed.ncbi.nlm.nih.gov/37838755/
A case report of psilocybin for lupus
Potential Benefits of Psilocybin for Lupus Pain: A Case Report
https://pubmed.ncbi.nlm.nih.gov/37670693/
For this week’s intriguing title…
Psychedelics and the neurobiology of meaningfulness
https://pubmed.ncbi.nlm.nih.gov/37730161/
A review of LSD for anxiety disorders
Lysergic Acid Diethylamide (LSD) for the Treatment of Anxiety Disorders: Preclinical and Clinical Evidence
https://pubmed.ncbi.nlm.nih.gov/37603260/
A review of using MDMA for PTSD & depression
MDMA Assisted Psychotherapy Decreases PTSD Symptoms, Dissociation, Functional Disability, and Depression: A Systematic Review and Meta-Analysis
https://www.medrxiv.org/content/10.1101/2023.08.17.23293955v1
And one on MDMA for PTSD
MDMA-Based Psychotherapy in Treatment-Resistant Post-traumatic Stress Disorder (PTSD): A Brief Overview of Current Evidence
https://www.preprints.org/manuscript/202308.1847/v1
And one on psilocybin for depression
Psilocybin-assisted therapy for depression: A systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/37844352/
In a mouse model of fragile X syndrome, DMT prevented seizures independently of serotonin & sigma1 receptors
The Psychedelic N, N-Dipropyltryptamine Prevents Seizures in a Mouse Model of Fragile X Syndrome via a Mechanism that Appears Independent of Serotonin and Sigma1 Receptors
https://pubmed.ncbi.nlm.nih.gov/37854624/
The Plant & the History
Here’s a beautiful chart of the terpenes from Randall Quarles of the Amazing Flower
https://theamazingflower.com/pages/terpenes
Growing & Farming
A cool feasibility study of using hemp as a cover crop in New Zealand vineyards
https://issuu.com/ruralnewsgroup/docs/final_hemp_cover_crop_trial_report_for_nzw?fr=xKAE9_zU1NQ
A more detailed genetic analysis (genotyping-by-sequencing (GBS)) showed that micropropagated plants are experiencing more mutations than shown in the simpler genomic sequencing analysis (simple sequence repeats (SSRs))
Genotyping-by-sequencing (GBS) reveals greater somatic mutations than simple sequence repeats (SSRs) in micropropagated cannabis plants
https://link.springer.com/article/10.1007/s11627-023-10377-x
Comparisons of different growing mediums & silicon on plant growth & nutrient uptake
Comparison of Peat–Perlite-based and Peat–Biochar-based Substrates with Varying Rates of Calcium Silicate on Growth and Cannabinoid Production of Cannabis sativa ‘BaOx’
https://journals.ashs.org/hortsci/view/journals/hortsci/58/10/article-p1250.xml
On strategies to mitigate the Aspergillus fungus
Aspergillus ecology and mitigation strategies in hemp production
https://extension.oregonstate.edu/community-vitality/health-outreach/aspergillus-ecology-mitigation-strategies-hemp-production
An analysis of the powdery mildew fungi of the Pacific Northwest
Characterization of powdery mildew fungi affecting hemp in the Pacific Northwest
https://apsjournals.apsnet.org/doi/pdf/10.1094/PHYTOFR-07-23-0099-R
On using microwaves for decarboxylating CBDA in hemp extracts
EFFECTS OF BATCH AND CONTINUOUS-FLOW MICROWAVE-ASSISTED PROCESS FOR THE DECARBOXYLATION OF CANNABIDIOLIC ACID IN HEMP EXTRACT
https://www.ijans.org/index.php/ijans/article/view/731
Hemp as food
The changes to glucose from the proteins of hemp seed meal
Hydrolysates of hemp (Cannabis sativa L.) seed meal: Characterization and their inhibitory effect on α-glucosidase activity and glucose transport in Caco-2 cells
https://www.sciencedirect.com/science/article/abs/pii/S0926669023013249
Looking for the best extraction techniques for CBD yield & antioxidant power for food products
Oil Extraction From Hemp Plant as a Potential Source of Antioxidants for Healthy Protein Foods
https://www.preprints.org/manuscript/202309.1838/v1
Industrial Use
On the potential of using hemp to harvest lithium from the soil
Effects of lithium on morpho-physiological and ionomic traits in Cannabis sativa L. microshoots under in vitro conditions
https://link.springer.com/article/10.1007/s11240-023-02606-3
Using hemp against Plodia interpunctella, the most destructive storage pest of sunflower
Phytotoxic and Insecticidal Activity of Industrial Hemp (Cannabis sativa L.) Extracts against Plodia interpunctella Hübner—A Potential Sunflower Grain Protectant
https://www.mdpi.com/2073-4395/13/10/2456
Using beta caryophyllene against mosquitoes
Synergistic Repellent and Irritant Effects of a Mixture of β-Caryophyllene Oxide and Vetiver Oil against Mosquito Vectors
https://pubmed.ncbi.nlm.nih.gov/37754741/
On using hemp & flax fibers to remove sedatives from polluted water
Modification of Waste Hemp and Flax Fibers for Removal of Selected Sedative Residues from Polluted Water
https://technorep.tmf.bg.ac.rs/handle/123456789/6644
An analysis of hempcrete under accelerated aging conditions
Experimental Study of the Dimensional and Hygrothermal Properties of Hemp Concrete under Accelerated Aging
https://www.mdpi.com/2075-5309/13/10/2414
CANNABINOID SCIENCE
A thesis project on how health care professionals with an expertise in cannabinoids acquired their knowledge
A Phenomenological Inquiry into Healthcare Professionals Who Are Experts in Cannabinoid Therapy and the Endocannabinoid System (ECS)
https://www.proquest.com/openview/4bacf18029b9ab8dc371cc76ec39efdb/1?pq-origsite=gscholar&cbl=18750&diss=y
Clinical Use, Surveys & Ingestions Methods
A brain scan study suggested potentially lower energy metabolism in cannabis users
Impact of cannabis use on brain metabolism using 31P and 1H magnetic resonance spectroscopy
https://pubmed.ncbi.nlm.nih.gov/37735222/
Workplace drug testing on the prevalence of delta-8 THC
Prevalence of Δ8-tetrahydrocannabinol carboxylic acid in workplace drug testing
https://pubmed.ncbi.nlm.nih.gov/37697897/
In determining blood THC concentrations, this test showed that taking samples from different time points is not a feasible way to extrapolate the earlier THC levels
A two-sample approach to retrograde extrapolation of blood THC concentrations - Is it feasible?
https://pubmed.ncbi.nlm.nih.gov/37793282/
A hospital's urine testing department confirms the accuracy of urinary drug screening in adolescents with no need for the follow-up immunoassay to confirm, but that it should be used for pediatric patients
Urine Toxicology Screening: Tetrahydrocannabinol Positivity Patterns at an U.S. Urban Tertiary Care Children's Hospital
https://academic.oup.com/clinchem/article/69/Supplement_1/hvad097.290/7283800
And an analysis of the effects of various methods for trying to cheat on your urine test
Effect of Urine Adulteration on Quantifying both Delta 8- and Delta 9-carboxy tetrahydrocannabinol using a New UPLC-tandem Mass Spectrometry Method
https://academic.oup.com/clinchem/article/69/Supplement_1/hvad097.499/7283661
Adolescents & Young People
In youth, religiosity was linked to a lower chance of using cannabis & while these researchers obviously saw that as a good thing, they said it was outside the realm of possibilities to promote a religion so we should consider non-faith-based volunteering activities instead
Influence of intrinsic and extrinsic religiosity on youth cannabis use: A structural equation modelling analysis on national survey on drug use and health (NSDUH) 2015–2019
https://www.sciencedirect.com/science/article/pii/S0022395623004211
Strangely, in states that legalized cannabis, adolescents had a reduced likelihood of having more than two sexual partners & no association with condom use
Recreational Cannabis Legalization and Adolescent Sexual Risk Behaviors
https://journals.sagepub.com/doi/abs/10.1177/0044118X231201438
An analysis of public health data showed that adolescents who use cannabis had an increased risk of an earlier age of onset for depression & anxiety
The Association Between Tobacco and Cannabis Use and the Age of Onset of Depression and Anxiety Symptoms: Among Adolescents and Young Adults
https://pubmed.ncbi.nlm.nih.gov/37042355/
Unsurprisingly, among young adults, the more days with simultaneous use of alcohol & cannabis led to more negative consequences
Daily-level simultaneous alcohol and marijuana use and its associations with alcohol use, marijuana use, and negative consequences in a young adult community sample
https://onlinelibrary.wiley.com/doi/abs/10.1111/acer.15145
A test of Europe’s survey on cannabis abuse screening
Country and sex measurement invariance of the Cannabis abuse screening test (CAST) in European Youth
https://pubmed.ncbi.nlm.nih.gov/37769386/
A French review of the consequences of adolescent cannabis use on adulthood
Cannabis use in adolescence : which consequences in adulthood ?
https://pubmed.ncbi.nlm.nih.gov/37712157/
Neurology & Brain Diseases
Among military veterans with a history of mild traumatic brain injury & PTSD, they had elevated levels of anandamide & arachidonic acid-derived oxylipins
Levels of Arachidonic Acid-Derived Oxylipins and Anandamide Are Elevated Among Military APOE ɛ4 Carriers With a History of Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder Symptoms
https://pubmed.ncbi.nlm.nih.gov/37786567/
A case report of a young person with a stroke attributed to cannabis use disorder
Stroke of Misfortune: Unpacking the Association between Cannabis and Young Stroke
https://www.researchgate.net/publication/374195565_Stroke_of_Misfortune_Unpacking_the_Association_between_Cannabis_and_Young_Stroke
A case report of controlling seizures after a brain tumor surgery with a 1:1 THC:CBD oil
CANNABINOIDES USE IN THE CONTROL OF CONVULSIVE CRISIS IN ASTROCYTOMA AFTER NEUROSURGERY: CASE REPORT
https://rbnp.emnuvens.com.br/rbnp/article/viewFile/999/293
A thesis project on the neuroprotective effects of cannabis extracts in a model of Parkinson's disease
In vivo Neuroprotective Effects of Cannabis sativa in Models of Parkinson’s Disease
https://etd.ohiolink.edu/acprod/odb_etd/etd/r/1501/10?clear=10&p10_accession_num=ohiou1691240188594231
Mental Health & Substance Use Disorders
In people with cannabis use disorder, they had higher concentrations of anandamide, oleamide, 2-AG & DHEA (with the latter inversely related to cannabis craving)
Circulating Endocannabinoids and N-Acylethanolamines in Individuals with Cannabis Use Disorder—Preliminary Findings
https://www.mdpi.com/2076-3425/13/10/1375
In public health data from two Canadian provinces, the legalization of cannabis was not linked to an increase in self-harm
An interrupted time series evaluation of the effect of cannabis legalization on intentional self-harm in two Canadian provinces: Ontario and Alberta
https://pubmed.ncbi.nlm.nih.gov/37707352/
A review of how cannabinoids modulate the neural circuits of pain & stress
Cannabinoid modulations of pain- and stress-related circuits
https://f.oaes.cc/xmlpdf/0bccf8ba-b7cc-4a96-9165-03aa85345564/and3019.pdf
In a model of stress, endocannabinoids helped to regulate behavioral adaptations via connections between the hippocampus (a memory center) & amygdala (a fear center)
Endocannabinoid release at ventral hippocampal-amygdala synapses regulates stress-induced behavioral adaptation
https://pubmed.ncbi.nlm.nih.gov/37703881/
In a mouse model of anxiety & fear, inhibiting a fatty acid binding protein in the amygdala lowered anxiety & quickens the extinction of fear memories
Inhibition of fatty acid binding protein-5 in the basolateral amygdala induces anxiolytic effects and accelerates fear memory extinction
https://pubmed.ncbi.nlm.nih.gov/37747506/
Female-specific, Reproduction & Hormones
In public health data, cannabis use during pregnancy increased the chances of adverse events as well as premature birth & small for gestational age
Maternal, Fetal and Neonatal Outcomes Related to Recreational Cannabis Use during Pregnancy: Analysis of a Real-World Clinical Data Warehouse between 2010 and 2019
https://pubmed.ncbi.nlm.nih.gov/37681826/
In public health data of pregnancies, there was no link between the preconception use of cannabis & the later development of gestational diabetes mellitus (but there was for tobacco)
The association between preconception cannabis use and gestational diabetes mellitus: The Preconception Period Analysis of Risks and Exposures Influencing health and Development (PrePARED) consortium
https://pubmed.ncbi.nlm.nih.gov/37751914/
In the placenta, how endocannabinoid levels are altered by labor & premature delivery
Labour and premature delivery differentially affect the expression of the endocannabinoid system in the human placenta
https://pubmed.ncbi.nlm.nih.gov/37750996/
A thesis project on how prenatal & lactation exposure to alcohol in mice altered the endocannabinoid system & caused cognitive impairments
The role of the expanded endocannabinoid system in cognitive impairments induced by prenatal and lactation alcohol exposure in mice
https://repositori.upf.edu/handle/10230/57980
The Guts, Metabolism, Oral Health & CHS
In mice, two endocannabinoid mediator derived from olive oil (N-oleoylglycine (OlGly)& N-oleoylalanine (OlAla)) lowered the reward of food & lessened obesity
Olive oil-derived endocannabinoid-like mediators inhibit palatable food-induced reward and obesity
https://pubmed.ncbi.nlm.nih.gov/37735539/
The Heart
On the unknowns of the cardiovascular effects of long-term cannabis use
Cardiovascular Effects of Long-Term Cannabis Use: More Questions Than Answers
https://pubmed.ncbi.nlm.nih.gov/37690937/
The Lungs
An unusual vaping related lung injury in an adolescent involving air in the chest cavity
Pneumomediastinum in Vaping-Associated Acute Lung Injury: An Unusual Presentation
https://assets.cureus.com/uploads/case_report/pdf/191146/20230922-4711-33rsxh.pdf
The Liver
In the liver, the minor cannabinoids have exceptional affinity for a fatty acid binding proteins (FABP1 – a transporter of cannabinoids)
Liver-Type Fatty Acid Binding Protein (FABP1) Has Exceptional Affinity for Minor Cannabinoids
https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/650dee5ab927619fe7a261db/original/liver-type-fatty-acid-binding-protein-fabp1-has-exceptional-affinity-for-minor-cannabinoids.pdf
The Genitourinary System
In obese humans with chronic kidney disease, they had endocannabinoid dysregulation in their kidneys
Renal Endocannabinoid Dysregulation in Obesity-Induced Chronic Kidney Disease in Humans
https://pubmed.ncbi.nlm.nih.gov/37686443/
“While serum eCB levels were similar between the lean and obese groups, kidney eCB analysis revealed higher anandamide in obese patients. Obese individuals also exhibited reduced expression of cannabinoid-1 receptor (CB1R) in the kidney, along with increased activity of eCB synthesizing and degrading enzymes. Correlation analysis highlighted connections between renal eCBs, kidney injury markers, obesity, and related pathologies.”
The Skin
In a comparison of melanocytes versus melanoma cells irradiated with UVA radiation, treatment by CBD & CBG partially reversed the pro-cancer changes
Differences in the phospholipid profile of melanocytes and melanoma cells irradiated with UVA and treated with cannabigerol and cannabidiol
https://pubmed.ncbi.nlm.nih.gov/37752196/
On methods to enhance the skin absorption of cannabinoids
Permeation-Enhancing Strategies for Transdermal Delivery of Cannabinoids
https://pubmed.ncbi.nlm.nih.gov/37751171/
Cancer & Chemotherapy
Of 182 medical cannabis patients with advanced cancer, none of them reached the threshold of a high risk for drug dependence
Drug dependence epidemiology in palliative care medicinal cannabis trials
https://pubmed.ncbi.nlm.nih.gov/37748856/
In breast cancer cells, CBD inhibited development
CBD Inhibits In Vivo Development of Human Breast Cancer Tumors
https://pubmed.ncbi.nlm.nih.gov/37686042/
In breast cancer cells, CBD & the CB1 antagonist Rimonabant changed the cellular interaction as well as the tumor microenvironment
Rimonabant and Cannabidiol Rewrite the Interactions between Breast Cancer Cells and Tumor Microenvironment
https://pubmed.ncbi.nlm.nih.gov/37686233/
In a mouse model of colon cancer, THC reduced the efficacy of the treatment drug irinotecan
Effects of concomitant use of THC and irinotecan on tumour growth and biochemical markers in a syngeneic mouse model of colon cancer
https://hrcak.srce.hr/file/444909
Synthetic Cannabinoids
German driver’s license exams show the prevalence of synthetic cannabinoid usage
Synthetic cannabinoids in hair-Prevalence of use in abstinence control programs for driver's license regranting in Germany
https://pubmed.ncbi.nlm.nih.gov/37731292/
Using tissue samples to test the toxicity effects of HHC
Evaluation of Preclinical in vitro Cytotoxicity, Genotoxicity, and Cardiac-Toxicity Screenings of Hydrogenated Cannabidiol
https://journals.sagepub.com/doi/pdf/10.1177/09731296231195941
And on the effects of ADB-HEXINACA on liver cells
The Metabolic Profile of the Synthetic Cannabinoid Receptor Agonist ADB-HEXINACA using Human Hepatocytes, LC-QTOF-MS and Synthesized Reference Standards
https://pubmed.ncbi.nlm.nih.gov/37747838/
On the metabolism of some of the new synthetic cannabinoids
In vitro metabolic profiling of new synthetic cannabinoids, ADB-FUBIATA, AFUBIATA, CH-FUBIATA, and CH-PIATA
https://pubmed.ncbi.nlm.nih.gov/37755504/
Cool Chemistry
Using lecithin vesicles for delivering cannabinoids
Giant multilamellar and large unilamellar lecithin vesicles for the encapsulation and oral delivery of cannabinoids
https://pubmed.ncbi.nlm.nih.gov/37690133/
On using promiscuous enzymes to create CBGA derivatives
Generation of Cannabigerolic Acid Derivatives and Their Precursors by Using the Promiscuity of the Aromatic Prenyltransferase NphB
https://pubmed.ncbi.nlm.nih.gov/37690998/
On a new drug class that inhibits both FAAH & HDAC (histone deacetylase enzymes, helpful for neuroprotection)
Pioneering first-in-class FAAH-HDAC inhibitors as potential multitarget neuroprotective agents
https://pubmed.ncbi.nlm.nih.gov/37750286/
On new drugs to activate the GPR55 receptor (which may one day be known as CB3)
Discovery and Characterization of Novel CNS-Penetrant GPR55 Agonists
https://pubmed.ncbi.nlm.nih.gov/37708305/
Thanks.
- lex
PS: Today’s classic folk album is ‘Bowling Green and Other Folk Songs from the Southern Mountains’ by the Kossoy Sisters. As the story goes, 50 years after recording this album, Ellen Kossoy was in a theater watching ‘O Brother Where Art Thou’ & was surprised to hear her own voice & that of her twin sister singing ‘I’ll Fly Away’. Now after decades apart living their own lives, the sisters are together again recording music.
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Wow! Check out that list! Thanks for another great piece!