C&P#81: first trial of CBD for acute dental pain + CBD for bipolar depression & hypertension

Toddlers exposed to cannabis in utero had better language acquisition & motor scores

Dec 05, 2023

Hello everyone,

Welcome to the 81^st edition of Cannabinoids & the People, a weekly newsletter where I collect all the new cannabinoid science. You can check out last week’s issue here & if you haven’t subscribed yet, please do. Sign up for a paid subscription to support my work disseminating all of the cannabinoid science.
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This week…

First clinical trial of CBD for acute dental pain

CBD for bipolar depression & hypertension

Cannabis still not great for the heart

Toddlers exposed to cannabis in the womb had better language & motor scores (?!)

The mostly positive effects of people using cannabis before surgery

CBD helps hippocampal cells hippocampalize!

If you have blood clots, you should smoke more weed?

Psychedelics for addiction

A request to spread the word
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Check out this (partial) bibliography:

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My work this week:

Canna-Education for CV Sciences
(TikTok:@cvsciences or my YouTube playlist 3-minute Cannabinoid Science):
Cannabis Book Week Begins! 'Smoke Signals', 'The Marijuana Conviction', & 'Cannabis Evolution & Ethnobotany'
'Sisters of the Extreme: Women Writing on the Drug Experience' by Cynthia Palmer & Michael Horowitz
3 Ways Cannabis Kills People
Cannabis "Causing Schizophrenia"
My Favorite Funny Hashish Story

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How I Improved My Tree of Life Memory Palace
How to Catergorize in a Memory Palace
AI & Memory Palaces & Psychedelics
Orality, Oral Cultures & Storytelling
A spiritual thirst trap: 'Rivers of Life or Faiths of Man in All Lands'
Taghairm & weird cruel divination
Nancy & 'Three Rocks: The Story of Ernie Bushmiller, the Man Who Created Nancy'
Two Great Songwriters: Mose Allison & Connie Converse
The Blues Piano of Emahoy Tsegué-Maryam Guèbrou
Lexomancy

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Best Of Cannabinoid Science...

Clinical

The first randomized control trial on CBD for dental pain found significant & quick pain reduction
Cannabidiol as an Alternative Analgesic for Acute Dental Pain
https://pubmed.ncbi.nlm.nih.gov/37910667/
The doses were 10 mg/kg (700 mg for a 70 kg/150 lb adult) up to 20 mg/kg (1400 mg).
“Compared to placebo, sedation, diarrhea, and abdominal pain were significantly associated with the CBD groups (P < 0.05). There were no other significant psychoactive or mood change effects.”

In a pilot study of CBD for acute bipolar depression, 300 milligrams of CBD per day over 8 weeks reduced scores of depression
Cannabidiol as an Adjunctive Treatment for Acute Bipolar Depression: A Pilot Study
https://pubmed.ncbi.nlm.nih.gov/37920963/

The ability of CBD to lower blood pressure in people with hypertension seems to be mediated by its reduction of inflammatory cytokines
Antihypertensive effects of CBD are mediated by altered inflammatory response: A sub-study of the HYPER-H21-4 trial
https://www.sciencedirect.com/science/article/pii/S1756464623004735

A large genetic analysis of endocannabinoid system variance & their link to mental disorders
Cross-disorder GWAS meta-analysis of endocannabinoid DNA variations in major depressive disorder, bipolar disorder, attention deficit hyperactivity disorder, autism spectrum disorder, and schizophrenia
https://pubmed.ncbi.nlm.nih.gov/37924773/
“The lead SNP was rs12805732 (Gene: Diacylglycerol Lipase Alpha; DAGLA). Four SNPs had substantial heterogeneity (I2>60 %). DAGLA had the strongest association with disease risk in gene-based analysis.”

In 1-year-old infants who had been exposed to cannabis in the womb, they had significantly better early language development & gross motor scores than those not exposed to cannabis
Prenatal cannabinoid exposure and early language development
https://www.frontiersin.org/articles/10.3389/fped.2023.1290707/full

In brain scans, cannabis users had smaller cerebellums(a center of muscle control), especially females, as well as smaller amygdalas (fear center) & worse sleep quality
Cannabis Affects Cerebellar Volume and Sleep Differently in Men and Women
https://pubmed.ncbi.nlm.nih.gov/34054601/

In people hospitalized with venous thromboembolism (blood clots), the users of cannabis had lower mortality rates, in-hospital complications, shorter hospital stays & slightly reduced cost
Venous thromboembolism and cannabis consumption, outcomes among hospitalized patients in the United States: A nationwide analysis
https://pubmed.ncbi.nlm.nih.gov/37907189/
But according to public health data, daily cannabis users had an increased risk of heart failure
Daily Marijuana Use is Associated With Incident Heart Failure: “All of Us” Research Program
https://www.ahajournals.org/doi/abs/10.1161/circ.148.suppl_1.13812
And this meta-analysis finds cannabis use associated with a significantly higher risk of atrial arrhythmias
Recreational Cannabis Use and the Risk of Atrial Arrhythmias: Evidence From a Meta-Analysis of Observational Studies
https://www.ahajournals.org/doi/abs/10.1161/circ.148.suppl_1.14161

In people treated for upper arm fractures, those using cannabis filled fewer opioid prescriptions
Cannabis Use Is Associated With Fewer Filled Opioid Prescriptions After Treatment of Proximal Humerus Fractures
https://pubmed.ncbi.nlm.nih.gov/37921529/

In people having elective spine surgery, the preoperative use of cannabis not associated with any changes in outcomes or postoperative pain relief
Short-Term Pain Outcomes and Pain Medication Utilization Among Urine Toxicology-Identified Opioid and Marijuana Users After Elective Spine Surgery
https://pubmed.ncbi.nlm.nih.gov/37861310/

A small study of the simultaneous effects from CBD & caffeine found that they really didn't interact that much
A preliminary investigation of the simultaneous effects of cannabidiol and caffeine
https://pubmed.ncbi.nlm.nih.gov/37917507/

In a survey of fibromyalgia patients, 15% report using cannabinoids
Significant use of non-evidence-based therapeutics in a cohort of Australian fibromyalgia patients
https://pubmed.ncbi.nlm.nih.gov/37872879/

Unsurprisingly, the COVID pandemic caused people to use more cannabis
Changes in self-reported cannabis use during the COVID-19 pandemic: a scoping review
https://pubmed.ncbi.nlm.nih.gov/37915021/

Oleamide may be important in the stabilization of our tears
Tear and Saliva Metabolomics in Evaporative Dry Eye Disease in Females
https://pubmed.ncbi.nlm.nih.gov/37999221/

Reviews

On how the exposure to opioids dysregulates the endocannabinoid system
Dysregulation of the endogenous cannabinoid system following opioid exposure
https://pubmed.ncbi.nlm.nih.gov/37931479/

For epilepsy, a review of 50 studies on the use of CBD
Long-term efficacy and adverse effects of cannabidiol in adjuvant treatment of drug-resistant epilepsy: a systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/37915501/
And a report on its adverse events from a database
Adverse events of epidiolex: A real-world drug safety surveillance study based on the FDA adverse event reporting system (FAERS) database
https://pubmed.ncbi.nlm.nih.gov/37949044/
And a genetic variant study of the endocannabinoids & epilepsy has a variant of CB1 & MAGL showing increased risks
Association between the endocannabinoid system-related gene polymorphisms and epilepsy
https://assets.researchsquare.com/files/rs-3459475/v1/607d8840-efa1-4656-bacd-93e7da03dd62.pdf?c=1698837506

Preclinical

In a mouse model of complex regional pain syndrome, local injections of CBD reduced the hypersensitivity to pain
Complex Regional Pain Syndrome Type I: Evidence for the CB1 and CB2 Receptors Immunocontent and Beneficial Effect of Local Administration of Cannabidiol in Mice
https://www.liebertpub.com/doi/abs/10.1089/can.2023.0093

In neural cells of the hippocampus (memory center of the brain), CBD promoted neurite (protrusions) growth, elongation & arborization as well as accelerating the process of axon specification
Promoting effects of cannabidiol on neurite growth and neuronal development in neuron-astrocyte sandwich coculture
https://onlinelibrary.wiley.com/doi/abs/10.1002/bkcs.12795
“The CBD treatment to the coculture system leads to noticeable increases in the longest-neurite length, primary-neurite number, and branch-point number, as well as the population of axon-determined neurons.”

In a mouse model of malaria, CBD was the strongest at increasing life expectancy
Investigation of the Efficacy of Cinnamaldehyde, Cannabidiol and Eravacycline in a Malaria Model
https://pubmed.ncbi.nlm.nih.gov/37885389/

In rats with bacteria in their pancreas, CBD protected via several different measures
Cannabidiol Mitigates Lipopolysaccharide-Induced Pancreatic Pathology: A Promising Therapeutic Strategy
https://pubmed.ncbi.nlm.nih.gov/37903028/

In human & rodent cells, CBD improved the expression of vitamin D3 receptors, inflammation, cell growth, tissue elasticity & enhanced mitochondrial bioenergetics
Cannabidiol (CBD) Upregulates Vitamin D3 Receptors (VDRs) Expression That Modulates Cytokines (TNF-α, IL-6), Tissue Elasticity, Cellular Senescence, and Mitochondrial ATP Generation in Human and Rodent Cell Lines
https://www.dovepress.com/cannabidiol-cbd-upregulates-vitamin-d3-receptors-vdrs-expression-that--peer-reviewed-fulltext-article-NDS

In rats, the pharmacokinetics of CBD into various tissues
Cannabidiol (CBD) Dosing: Plasma Pharmacokinetics and Effects on Accumulation in Skeletal Muscle, Liver and Adipose Tissue
https://pubmed.ncbi.nlm.nih.gov/35631242/

An evergreen note on reading restricted papers:
First stop for seeing if there’s a free version of a paper, use the Google Scholar Chrome extension (Mac version), Google Scholar itself or try ResearchGate.
Three other helpful browser extensions are: Unpaywall, Open Access Button & PaperPanda
For the infamous backdoor, use Sci-Hub – the pirated papers repository (Chrome extension here). This works better for older paper than the stuff that just came out.
Finally, email the author. They’re almost always happy to oblige because, thanks to the predatory academic publishing system, they don’t make a dollar off of their papers.

the Headlines & Fav Articles

In Canada, Epidiolex (pharmaceutical isolated CBD) approved for treating three rare forms of epilepsy
https://www.newswire.ca/news-releases/jazz-pharmaceuticals-receives-health-canada-approval-for-epidiolex-r-cannabidiol-oral-solution-for-the-treatment-of-seizures-associated-with-three-rare-forms-of-epilepsy-830546952.html

The USDA threatens to revoke the hemp licenses of farmers who also grow THC-rich cannabis even if they’re legal under state programs
https://www.marijuanamoment.net/usda-threatens-to-revoke-hemp-licenses-for-farmers-who-also-grow-marijuana-under-state-programs/

NYC sends letters to the landlords of illegal tobacco & cannabis shops
https://www.nyc.gov/office-of-the-mayor/news/900-23/mayor-adams-cracks-down-landlords-illegal-smoke-shops

For Black Friday, California & New York State officials tell people to buy cannabis
https://www.marijuanamoment.net/california-and-new-york-state-officials-tell-people-to-buy-marijuana-on-black-friday/

The governors of Wisconsin & Missouri pardoning piles of cannabis convictions
https://www.marijuanamoment.net/wisconsin-governor-grants-dozens-of-marijuana-pardons-as-advocates-pressure-gop-leaders-to-advance-legalization/
https://apnews.com/article/pardon-clemency-missouri-governor-mike-parson-wisconsin-dc788c33d850956460a567554b1a8104
(check out the drum solo by MO’s Gov. Mike Parsons)

A secret buyer survey of delta-8 THC found the labeled levels to be only weakly accurate, plus delta-9 THC was found in a third of the products
Commercial Delta-8 THC Products: an Analysis of Content and Labeling
https://pubmed.ncbi.nlm.nih.gov/37917314/

An analysis of YouTube videos to find out how everyone is modifying their vape juices
Electronic Nicotine Delivery Systems and E-Liquid Modifications to Vape Cannabis Depicted in Online Videos
https://pubmed.ncbi.nlm.nih.gov/37917060/

History Corner: Napoleon banned hashish because his soldiers in Egypt were getting too high
https://hightimes.com/news/world/napoleon-bonaparte-banned-cannabis-because-his-soldiers-were-getting-too-high/
And read Abel to see how this led to the infamous Club des Hashischins
https://druglibrary.org/schaffer/hemp/history/first12000/8.htm

International

A bill to legalize medical marijuana in Ukraine blocked by hundreds of “spam” amendments
https://www.marijuanamoment.net/ukrainian-lawmakers-approve-medical-marijuana-legalization-bill-in-committee-putting-it-one-more-vote-from-zelenskys-desk/

On the potential of Ghana to become a leader in the African hemp industry
The potential for Ghana to become a leader in the African hemp industry
https://pubmed.ncbi.nlm.nih.gov/37899465/

The Laws, The War on Drugs & the End of Prohibition

The Lancet comes out for drug decriminalization
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02617-X/fulltext

Drug sniffing dogs false alert 75% of the time
https://internationalcbc.com/drug-sniffing-dogs-false-alert-75-of-the-time-according-to-australian-study/

A big review of almost 450 studies on the effects of cannabis laws mostly highlights the gaps in the research
Health, safety, and socioeconomic impacts of cannabis liberalization laws: An evidence and gap map
https://pubmed.ncbi.nlm.nih.gov/37915420/

In states with no recreational cannabis laws, their emergency departments had significantly lower “treat and release” cannabis use disorder visits, especially among Black people, suggesting that Prohibition keeps people from getting treated
The impact of recreational cannabis laws on cannabis use disorder during "treat and release" visits to hospital emergency departments in four U.S. states, 2017-2020
https://pubmed.ncbi.nlm.nih.gov/38021411/

States with legal cannabis had more adolescents using in middle school
Legalization and retail availability of recreational marijuana and adolescent use in schools
https://pubmed.ncbi.nlm.nih.gov/37801408/
And a review of the impact of cannabis legalization on adolescent cannabis use
Impact of Cannabis Legalization on Adolescent Cannabis Use
https://pubmed.ncbi.nlm.nih.gov/37879828/

In Washington, cannabis dispensaries had no impact on most local crime, but a small rise in property crime in low-income neighborhoods
The impact of recreational marijuana dispensaries on crime: evidence from a lottery experiment
https://link.springer.com/article/10.1007/s00168-023-01246-x

States with medical cannabis had less non-medical prescription opioid use, though this was driven by individuals with cannabis use disorder
Association Between Legal Access to Medical Cannabis and Frequency of Non-Medical Prescription Opioid Use Among U.S. Adults
https://link.springer.com/article/10.1007/s11469-023-01191-y

The legalization of medical cannabis not linked to rising stimulant prescription rates
Medical Cannabis Legalization: No Contribution to Rising Stimulant Rates in the USA
https://pubmed.ncbi.nlm.nih.gov/37884027/

Psychedelics, Plant Medicines & Other Psychoactives

The Psychoactive Research

[This isn’t a deep dive into the science of psychedelics & other psychoactives like I do for the cannabinoids. If your organization would be interested in a breakdown of all the new psychedelic science, reach out to me]

A survey of people whose psychedelic experience led to a reduction in alcoholic use & increased psychological flexibility
Reduction of alcohol use and increase in psychological flexibility after a naturalistic psychedelic experience: a retrospective survey
https://pubmed.ncbi.nlm.nih.gov/37981297/

The targets of iboga components & their anti-addictive effects
Main targets of ibogaine and noribogaine associated with its putative anti-addictive effects: A mechanistic overview
https://pubmed.ncbi.nlm.nih.gov/37937505/

For eating disorders, the perspectives of ayahuasca ceremony leaders on special considerations
Ayahuasca ceremony leaders' perspectives on special considerations for eating disorders
https://pubmed.ncbi.nlm.nih.gov/37943076/

On creating a clinical ayahuasca analog
Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine
https://www.frontiersin.org/articles/10.3389/fphar.2023.1246892/full

A review on the interplay between music & psychedelics
Psychedelia: The interplay of music and psychedelics
https://pubmed.ncbi.nlm.nih.gov/37983198/

On potential drug-drug interactions with the classic psychedelics
Drug-drug interactions involving classic psychedelics: A systematic review
https://pubmed.ncbi.nlm.nih.gov/37982394/
“The findings revealed various effects when psychedelics were combined with other drugs, including both attenuated and potentiated effects, as well as instances where no changes were observed. Except for a few case reports, no serious adverse drug events were described in the included studies.”

A review of using psychedelics to treat pain covers 21 papers
Use of Psychedelics for Pain: A Scoping Review
https://pubmed.ncbi.nlm.nih.gov/37698433/

A review of using psilocybin to treat depression
Potential use of psilocybin drugs in the treatment of depression
https://pubmed.ncbi.nlm.nih.gov/37817501/

For Alzheimer's disease, a thesis project on the potential of using psychedelics
The Potential Role of Psychedelic Therapy in Alzheimer’s Dementia
https://scholar.valpo.edu/sires/171/

On how psychedelics control prefrontal pyramidal neurons
Cellular rules underlying psychedelic control of prefrontal pyramidal neurons
https://pubmed.ncbi.nlm.nih.gov/37961554/

The Plant & the History

Growing & Farming

On using spectral imagery to detect stress in greenhouse hemp plants
Early Detection of Stress in Greenhouse-Grown Industrial Hemp Plants by Hyperspectral Imaging
https://budscout.ai/wp-content/uploads/2023/03/Early-Detection-of-Industry-Hemp-Plant-in-Greenhouse-by-Hyperspectral-Technique.pdf

In stored cannabis, higher temperatures led to more conversion from THCA to THC
Effects of temperature on THC and THCA content during storage
https://www.researchgate.net/publication/373810816_Effects_of_temperature_on_THC_and_THCA_content_during_storage

On leaf position & nutrient deficiencies
A Survey of Nutrient Levels in Floral Hemp (Cannabis sativa L.) Grown for Cannabinoids and the Influence of Leaf Position for Determining Nutrient Deficiencies
https://repository.lib.ncsu.edu/bitstream/handle/1840.20/41352/etd.pdf?sequence=1

On growing organically to produce seeds
Features of forming the productivity of modern hemp varieties using organic cultivation technology
http://ir.polissiauniver.edu.ua/bitstream/123456789/14412/1/SH_2023_26_7_54-65.pdf

On how to store seeds & explants in cold storage for clonal propagation
In vitro preservation of somatic seeds and nonencapsulated hemp explants
https://sciforum.net/paper/view/15146

A genome study suggests the WRKY transcription factors as regulators of cannabinoid levels
Genome-wide identification and expression profiling of WRKY family suggest their potential role in cannabinoid regulation in Cannabis sativa L
https://www.sciencedirect.com/science/article/abs/pii/S0926669023014711

The genomes of six bacteria isolated from cannabis root soil
Draft genome sequences of six bacterial strains isolated from Cannabis rhizosphere soil
https://pubmed.ncbi.nlm.nih.gov/37905812/

Hemp as food

On making meat analogs from hemp
High moisture meat analogues from hemp – The effect of co-extrusion with wheat gluten and chickpea proteins on the textural properties and sensorial attributes
https://www.sciencedirect.com/science/article/pii/S0023643823010733

On extracting CBD from hemp stalks for protein bars
Oil Extraction from Hemp Plant as a Potential Source of Cannabidiol for Healthy Protein Foods
https://pubmed.ncbi.nlm.nih.gov/38001803/

On the effects of infrared pretreatment on hemp seed oil
Infrared pretreatment for improving oxidative stability, physiochemical properties, phenolic, phytosterol and tocopherol profile of hemp (Cannabis sativa L.) seed oil
https://www.sciencedirect.com/science/article/abs/pii/S092666902301470X

On the major metabolites in hemp seeds grown in Bama, China (known as the longevity village)
Widely targeted metabolomics analysis reveals the major metabolites in the hemp seeds from the longevity village of Bama, China
https://www.sciencedirect.com/science/article/abs/pii/S0926669023014267

On the fatty acid profile of cannabis achenes
Morphometry, Oil Yield and Fatty Acid Profile of Cannabis Achenes from the Chefchaouen Region
https://revues.imist.ma/index.php/morjchem/article/view/42058

Industrial Use

Trial of using hemp to remediate soil contaminated with PFAs (forever chemicals)
A Comprehensive Trial on PFAS Remediation: Hemp Phytoextraction and PFAS Degradation in Harvested Plants
https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/6542569bc573f893f194767e/original/a-comprehensive-trial-on-pfas-remediation-hemp-phytoextraction-and-pfas-degradation-in-harvested-plants.pdf

On using hemp waste as a matrix for growing mushrooms
Use of Hemp Waste for the Development of Mycelium-grown Matrix Biocomposites: A Concise Bibliographic Review
http://ojs.cnr.ncsu.edu/index.php/BRJ/article/view/22934

On strengthening thermoplastic starch with hemp
Thermoplastic starch biocomposites reinforced with hemp shives obtained via extrusion
https://www.sciencedirect.com/science/article/abs/pii/S0926669023014723

On creating an organic geotextile using bitumen & hemp
Organic based geotextile production proposal with bitumen and hemp
https://www.researchgate.net/publication/375073955_Organic_based_geotextile_production_proposal_with_bitumen_and_hemp

A very positive take on using hemp to build the houses of Canada
The Extent to Which Hemp Insulation Materials Can Be Used in Canadian Residential Buildings
https://www.mdpi.com/2071-1050/15/19/14471

On the potential of industrial hemp in India
Industrial Hemp in India: A Booming Botanical Wonder with Endless Potentials
https://www.researchgate.net/publication/375120319_Industrial_Hemp_in_India_A_Booming_Botanical_Wonder_with_Endless_Potentials

On the role of hemp in the textile industry
Industrial Cannabis sativa: Role of hemp (fiber type) in textile industries
https://www.researchgate.net/publication/375325712_Industrial_Cannabis_sativa_Role_of_hemp_fiber_type_in_textile_industries

CANNABINOID SCIENCE

Clinical Trials, Surveys & Ingestion Methods

On the potential drug interactions from the cannabinoids
Drug interactions with Cannabis sativa: Mechanisms and clinical implication
https://www.sciencedirect.com/science/article/abs/pii/S2352007823003244

A review of physician attitudes towards cannabis use and present the importance of discussing cannabis with patients (a very SF-style article)
A Pragmatic, Person-Centered View of Cannabis in the United States: Pursuing Care That Transcends Beliefs
https://pubmed.ncbi.nlm.nih.gov/37902034/

In people waiting for a liver transplant, females may face more bias for the recreational use of cannabis
Sex Differences in the Impact of Marijuana Use on Liver Transplant Access
https://journals.lww.com/ajg/fulltext/2023/10001/s1610_sex_differences_in_the_impact_of_marijuana.2571.aspx

Adolescents & Young People

A review of brief interventions that can be used for adolescents having problems with cannabis
Brief Interventions for Cannabis Using Adolescents
https://pubmed.ncbi.nlm.nih.gov/37879837/

In children with accidental cannabis intoxication, this retrospective study found high rates of head imaging & lumbar punctures that could be avoided if cannabis ingestion is considered early & identified quickly
Do young children with known cannabis intoxication benefit from further neurological-based testing or imaging?
https://pubmed.ncbi.nlm.nih.gov/37944295/

In US adolescents, psychological distress was linked with cannabis vaping
Psychological Distress and Cannabis Vaping Among U.S. Adolescents
https://pubmed.ncbi.nlm.nih.gov/37866491/

On negative life events & their relationship to the age of initiation for alcohol & cannabis as well as their brain structures
Neural correlates of negative life events and their relationships with alcohol and cannabis use initiation
https://pubmed.ncbi.nlm.nih.gov/37916739/

Mental Health & Substance Use Disorders

On the relationship between trauma, cortisol, endocannabinoids & the later development of PTSD
Endocannabinoids, cortisol, and development of post-traumatic psychopathological trajectories
https://pubmed.ncbi.nlm.nih.gov/37956620/

The Immune System

In a mouse model of sepsis, activating the CB2 receptor decreased levels of heart damage & inflammation, possibly by the inhibition of pyroptosis (a highly inflammatory mode of regulated cell death)
Activation of cannabinoid receptors 2 alleviates myocardial damage in cecal ligation and puncture-induced sepsis by inhibiting pyroptosis
https://pubmed.ncbi.nlm.nih.gov/37918639/

Canine immune cells have high levels of cannabinoid receptors & are very sensitive to their effects
Canine immune cells express high levels of CB1 and CB2 cannabinoid receptors and cannabinoid-mediated alteration of canine cytokine production is vehicle-dependent
https://pubmed.ncbi.nlm.nih.gov/37931433/

Hormones, Reproduction & Prenatal Effects

In a study of pregnant women, previous trauma & PTSD from childbirth, factors associated with an increased risk for childbirth-related PTSD symptoms include a greater level of lifetime trauma & reduced maternal hair anandamide levels during pregnancy
Childbirth-related posttraumatic stress symptoms - examining associations with hair endocannabinoid concentrations during pregnancy and lifetime trauma
https://pubmed.ncbi.nlm.nih.gov/37907467/

In pregnant people, those with & without a history of depression had an increased risk of postpartum depression if they used cannabis
Incidence of postpartum depression in low-income cannabis users with and without a history of depression
https://link.springer.com/article/10.1007/s00737-023-01389-y

In female rats taking contraception, giving them cannabinoids did not significantly alter their motor & cognitive skills or induce anxiety or depressive states
Behavioral characterization of co-exposure to cannabinoids and hormonal contraceptives in female rats
https://pubmed.ncbi.nlm.nih.gov/37926338/

In rats, the prenatal exposure to synthetic cannabinoids caused adolescent females to drink more alcohol (but not males) & for both genders, a hyperactivity when combined with alcohol prenatal exposure
The impact of prenatal alcohol and synthetic cannabinoid exposure on behavioral adaptations in adolescent offspring and alcohol self-administration in adulthood
https://pubmed.ncbi.nlm.nih.gov/37873078/

Pain & Surgeries

In chronic pain patients, those with worse pain burdens were more likely to be using cannabis
Association of cannabis use with patient-reported pain measures among adults with chronic pain in US states with medical cannabis programs
https://pubmed.ncbi.nlm.nih.gov/37923347/

The Guts, Metabolism, Oral Health & CHS

In people with obesity, the efficacy of the new glucagon-like peptide-1 (GLP-1) drugs may be predicted by the person's levels of anandamide & oleamide
Endocannabinoid-related molecules predict the metabolic efficacy of GLP-1 receptor agonism in humans with obesity
https://pubmed.ncbi.nlm.nih.gov/37924474/

A public health data analysis of cyclical vomiting syndrome & cannabis usage
Cannabis use and cyclical vomiting syndrome: An open debate
https://pubmed.ncbi.nlm.nih.gov/37880016/

In a mouse model of obesity, the terpene beta-caryophyllene caused weight loss & improve the lipid balance via the CB2 receptor, SIRT1/PGC-1α/PPARγ signaling pathway & SIRT1/AMPK signaling pathway
Mechanisms of weight-loss effect in obese mice by the endogenous cannabinoid receptor 2 agonist beta-caryophyllene
https://pubmed.ncbi.nlm.nih.gov/37919194/

In a rat model of metabolic dysfunction, H4CBD (a synthetic analog of CBD) may improve glucose response via a loss of body fat
Pseudocannabinoid H4CBD improves glucose response during advanced metabolic syndrome in OLETF rats independent of increase in insulin signaling proteins
https://pubmed.ncbi.nlm.nih.gov/37899754/

In mice, a genetic variant of the FAAH enzyme increased their feeding mediated by the orexigenic hormones such as ghrelin
A genetic variant of fatty acid amide hydrolase (FAAH) exacerbates hormone-mediated orexigenic feeding in mice
https://pubmed.ncbi.nlm.nih.gov/37039453/

The Heart & Blood

Behind a paywall is this study about the inhalation of THC diminishing cardiac autonomic function
Inhalation of THC-containing cannabis selectively diminishes cardiac autonomic function in humans
https://link.springer.com/article/10.1007/s10286-023-00993-3

Sila-CBD derivatives lower inflammation in heme (the nonprotein part of hemoglobin) via the NLRP3 inflammasome, suggesting utility for sickle cell anemia & thalassemia
Sila-CBD Derivatives as Inhibitors of Heme-Induced NLRP3 Inflammasome: Application in Hemolytic Diseases
https://pubs.acs.org/doi/abs/10.1021/acsmedchemlett.3c00352

The Lungs

On the history of vapes & their impact on the lungs
Impact of Vaping on Lungs: An Indian Prospect
https://assets.cureus.com/uploads/review_article/pdf/199352/20231105-17631-1ipg3p3.pdf

Cancer & Chemotherapy

For melanoma, a review of the rationale for cannabinoids as an additive treatment
Rationalizing a prospective coupling effect of cannabinoids with the current pharmacotherapy for melanoma treatment
https://pubmed.ncbi.nlm.nih.gov/37920964/

A small section on the link between cannabis use & the development of testicular cancer
27-year trends in incidence rates for testis cancer across a large statewide registry
https://pubmed.ncbi.nlm.nih.gov/37941643/

In cancer cells, how the protein levels change with treatment by CBD & THC
Proteome-Wide Profiling Using Sample Multiplexing of a Human Cell Line Treated with Cannabidiol (CBD) and Tetrahydrocannabinol (THC)
https://pubmed.ncbi.nlm.nih.gov/37987316/

In a mouse model of breast cancer, inhibition of the FAAH enzyme reduced cancer growth & combined well with exogenous endocannabinoid treatment
FAAH inhibition ameliorates breast cancer in a murine model
https://pubmed.ncbi.nlm.nih.gov/37921652/

In lung cancer cells hit by gamma ray radiation, how the survivors had enhanced migration via the cannabinoid & adenosine receptors
Involvement of cannabinoid receptors and adenosine A2B receptor in enhanced migration of lung cancer A549 cells induced by γ-ray irradiation
https://pubmed.ncbi.nlm.nih.gov/37926527/

Cool Chemistry & Tools

On the conformational dynamics of how new cannabinoids bind to the CB1 receptor
Transition-based reweighting and neural rational inference analysis of effects of new psychoactive substances on cannabinoid receptors
https://pubmed.ncbi.nlm.nih.gov/37873328/

On the toxicology of HHC
Analytical toxicology of the semi-synthetic cannabinoid hexahydrocannabinol studied in human samples, pooled human liver S9 fraction, rat samples, and drug product using HPLC-HRMS/MS
https://pubmed.ncbi.nlm.nih.gov/37864499/

On drugs to inhibit the MAGL enzyme derived from benzylpiperidine
Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors
https://pubmed.ncbi.nlm.nih.gov/37976705/

Thanks.
- lex

PS: My buddy Todd Amodeo is a master of the playlist & his ‘Joy to the World (A Holiday Shuffle Mix’ is a masterpiece. 18 hours of music from around the world & across the genres. It’s a work of art & my family has been listening to it for a week straight with no end in sight. Thanks Todd & happy holidays everyone!

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Cannabinoids & the People