C&P#84: cannabinoids for stress, PTSD & neuropathic pain + prenatal & sperm effects
C&P#84: cannabinoids for stress, PTSD & neuropathic pain + prenatal & sperm effects
Good & bad news from the states & provinces
Hello everyone,
Welcome to the 84th edition of Cannabinoids & the People, a weekly newsletter where I collect all the new cannabinoid science. You can check out last week’s issue here & if you haven’t subscribed yet, please do. Sign up for a paid subscription to support my work sharing cannabinoid science.
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Announcements
No newsletter next week because I’m taking my oldest to my family home in PA to celebrate her 6th birthday.
I’ll see you the second week of January with a refreshed design of ‘Cannabinoids & the People’!
This week…
How cannabinoids help with stress responses & coping
Again, cannabis for PTSD & neuropathic pain
More on prenatal cannabinoid exposure effects
Sperm slowed by the cannabinoids
Cannabinoids found in the Jamaican nettletree
#partiersgottaparty
A poor kid who swallowed a vape pen cartridge because of the cops coming
A request to spread the word
This newsletter only spreads by word of mouth,
so please forward to colleagues & tell your friends & relatives.
Sponsor: PlusCBD’s unparalleled product selection
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Buy their excellent products today at PlusCBDoil.com.
My work this week:
Canna-Education for CV Sciences
(TikTok:@cvsciences or my YouTube playlist 3-minute Cannabinoid Science):
The Holistic Effects on Chronic Pain
Caffeine & the Cannabinoids (12k views)
Parenting & the Plant
Marriage & Our Favorite Plant
Terpene Tuesday: Eucalyptol (1,8 - Cineole)
My TikToks (@lexpelgerandhisbooks or on YouTube):
Warnings on K Medical Experiences & Providers + K & Fatal Overdoses
Blake's 'The Gates of Paradise' (I wish people liked Blake like they like ketamine)
Books, Zoroaster & Pseudepigrapha
Favorite Short Story Writers
My platforms: Linktree
YouTube for educational videos, lectures & shorts on new cannabinoid science
Anandamide; or, the People: my graphic novel series on cannabis, the endocannabinoid system & the War on Drugs based on Moby-Dick
My podcasts
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Best Of Cannabinoid Science...
A history of Brazil's 50 years of research on CBD as an anticonvulsant
Fifty years of research on cannabidiol (CBD) as an anticonvulsant: The legacy of Brazilian groups
https://pubmed.ncbi.nlm.nih.gov/38007685/
Clinical
In a small study of people with PTSD, medical cannabis use improved their mental health & symptom severity scores, especially in reductions of nightmares & improved sleep quality
Improved Post-Traumatic Stress Disorder Symptoms and Related Sleep Disturbances after Initiation of Medical Marijuana Use: Evidence from a Prospective Single Arm Pilot Study
https://pubmed.ncbi.nlm.nih.gov/37965569/
It's interesting to note that most of the changes occurred in the first 30 days but the improvement to nightmares didn't show up until 70 days. Sometimes with the cannabinoids, it takes time for them to work.
In a Thai study of neuropathic pain patients, cannabis caused almost half of them to have at least a 30% reduction of pain scores & many saw significant improvements in quality of life, especially sleep - but as always around 10% could not tolerate this side effects & had to stop using medical cannabis
Efficacy and Safety of Medical Cannabis in Neuropathic Pain Patients
https://he02.tci-thaijo.org/index.php/anesthai/article/view/266158
And this review of how the cannabinoids & beta caryophyllene help with neuropathic pain
IUPHAR review- Preclinical models of neuropathic pain: Evaluating multifunctional properties of natural cannabinoid receptors ligands
https://pubmed.ncbi.nlm.nih.gov/38008135/
In people using cannabis to cope with anxiety, they had better sleep on the days they used cannabis, but not after alcohol use
Daily diary study of associations between alcohol, cannabis, co-use and sleep quality in individuals with intentions to use cannabis to cope with anxiety
https://pubmed.ncbi.nlm.nih.gov/37985016/
From Quebec public health data, the adverse event reports of cannabis
A Descriptive Analysis of Adverse Event Reports from the Quebec Cannabis Registry
https://pubmed.ncbi.nlm.nih.gov/37996777/
“The most common PTs [preferred terms for an adverse event] for ingested MC [medical cannabis] (62 reports) were dizziness (12.9%), nausea (11.3%), somnolence (9.7%), and vomiting (8.1%), and for inhaled MC (23 reports), headache (13.0%) was the most common. The most frequent PTs associated with tetrahydrocannabinol (THC)-dominant MC (25 reports) were dizziness and somnolence (12.0% each); for cannabidiol (CBD)-dominant MC (20 reports), vomiting (20.0%) was most common; and dizziness (17.2%), nausea (13.8%), somnolence (10.3%), and headache (8.6%) were the most frequent for balanced MC (58 reports).”
In a public health study of infants exposed to cannabis in the womb, they had an increased likelihood of low birth weight, small for gestational age, preterm birth & more neonatal intensive care unit admissions
Neonatal outcomes associated with in utero cannabis exposure: a population-based retrospective cohort study
https://pubmed.ncbi.nlm.nih.gov/38029850/
And in rats with repeated prenatal exposure to cannabis smoke, they had more male babies & those offspring spent less time exploring open fields but did better at visual discrimination & reversal learning tasks
Repeated Exposure to High-THC Cannabis Smoke during Gestation Alters Sex Ratio, Behavior, and Amygdala Gene Expression of Sprague Dawley Rat Offspring
https://pubmed.ncbi.nlm.nih.gov/37957008/
And in mice, prenatal exposure to a drug that activates the CB1 receptor caused a range of memory deficits via the hippocampus
Prenatal Cannabinoid Exposure Elicits Memory Deficits Associated with Reduced PSA-NCAM Expression, Altered Glutamatergic Signaling, and Adaptations in Hippocampal Synaptic Plasticity
https://pubmed.ncbi.nlm.nih.gov/37947603/
Genetic analysis found a correlation between cannabis use disorder & type 2 diabetes, suggesting that cannabis use disorder may have a causal role in several diabetic disease phenotypes
Genetic Insights into the causal relationship between cannabis use and diabetic phenotypes: A genetic correlation and Mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/38016197/
And a genome association study & public health data do not support an association between cannabis use & developing glaucoma
Cannabis use and the risk of primary open-angle glaucoma: a Mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/37949880/
A case report of a THC sleep aid causing liver injury, probably because it contained corydalis extract (an herbal supplement recently found to be injurious to the liver)
Tetrahydrocannabinol-Containing Sleep Aid Supplements: An Unexpected Cause of Drug-Induced Liver Injury
https://journals.lww.com/ajg/fulltext/2023/10001/s3447_tetrahydrocannabinol_containing_sleep_aid.3674.aspx
A possible case of cannabinoid hyperemesis syndrome
Recurrent Intractable Nausea, Vomiting, and Abdominal Pain in a Patient With A1c >12, QTc >500
https://journals.lww.com/ajg/fulltext/2023/10001/s4155_recurrent_intractable_nausea,_vomiting,_and.4153.aspx
And a review on managing cannabinoid hyperemesis syndrome
Cannabinoid Hyperemesis Syndrome: Prevalence and Management in an Era of Cannabis Legalization
https://pubmed.ncbi.nlm.nih.gov/37997432/
In dogs, the tolerability of 36 weeks of CBD
Tolerability of long-term cannabidiol supplementation to healthy adult dogs
https://pubmed.ncbi.nlm.nih.gov/38009749/
A dose of 5 mg/kg/day was well tolerated. At 10 mg/kg/day, this group had a higher frequency of soft feces. And in all treatment groups, they had high ALP liver enzyme activity, but that was the only difference found in the blood work.
In horse’s trigeminal ganglions (the nerve that gathers sensory stimuli from the head), they had CB1, CB2, TRPV1 & PPAR receptors
Expression of Cannabinoid Receptors in the Trigeminal Ganglion of the Horse
https://pubmed.ncbi.nlm.nih.gov/37958932/
Reviews
A thoughtful review of cannabinoids for stress responses & coping (with some great charts on the diversity of their effects & binding)
Anxiety Modulation by Cannabinoids-The Role of Stress Responses and Coping
https://pubmed.ncbi.nlm.nih.gov/37958761/
This review is so in-depth & well-thought out that I’m planning on doing a video on it today.
For the cognitive dysfunction of Alzheimer's disease, the role of the endocannabinoid system in the brain’s astrocytes (key support cells that make up the majority of cells in the CNS)
Interplay Between Astroglial Endocannabinoid System and the Cognitive Dysfunction in Alzheimer's Disease
https://pubmed.ncbi.nlm.nih.gov/38015757/
For investigating the endocannabinoid system in the brain, a review of imaging & genetic tools
Imaging and Genetic Tools for the Investigation of the Endocannabinoid System in the CNS
https://pubmed.ncbi.nlm.nih.gov/37958825/
Preclinical
In a female rat model of oxycodone use disorder, self-administration is enhanced by THC, but not by CBD
Oxycodone Self-Administration in Female Rats is Enhanced by ∆9-tetrahydrocannabinol, but not by Cannabidiol, in a Progressive Ratio Procedure
https://pubmed.ncbi.nlm.nih.gov/37961225/
In a mouse model of obesity, cannabis oil in the mice fed a sucrose-rich diet had increased painkilling effects & decreased locomotion as well as decreases in systolic & diastolic blood pressures
Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
https://sedici.unlp.edu.ar/bitstream/handle/10915/160491/Documento_completo.pdf-PDFA.pdf?sequence=1
Sperm treated with THC, CBD or the THC metabolite THC-COOH caused a significant slowdown in their motion & in the number of immobile sperm
The effects of Cannabis compounds (THC, CBD, and THC-COOH) on Sperm Motility in Male Participants: A Prospective Study
https://ijwhr.net/pdf/pdf_IJWHR_704.pdf
In a rat model of retinal diseases, treatment with 2AG lowered CB1 levels & abolished their neuroprotective actions but also lessened activation of the microglia (guardian immune cells) via the CB2 receptors & overall, topical 2AG was efficacious as a neuroprotectant/antiapoptotic & anti-inflammatory agent
Investigating the Effects of Exogenous and Endogenous 2-Arachidonoylglycerol on Retinal CB1 Cannabinoid Receptors and Reactive Microglia in Naive and Diseased Retina
https://pubmed.ncbi.nlm.nih.gov/37958673/
A thesis project in roundworms finds that the pain-fighting activity of CBD & THC are mediated by distinct receptors
Cannabidiol and tetrahydrocannabinol antinociceptive activity is mediated by distinct receptors in caenorhabditis elegans
https://papyrus.bib.umontreal.ca/xmlui/handle/1866/32071
A cannabinoid secreting trichrome found in the Jamaican nettletree (Trema micranthum)
The putative cannabinoid-secreting trichome of Trema micrantha (L.) Blume (Cannabaceae)
https://pubmed.ncbi.nlm.nih.gov/37999805/
An evergreen note on reading restricted papers:
First stop for seeing if there’s a free version of a paper, use the Google Scholar Chrome extension (Mac version), Google Scholar itself or try ResearchGate.
Three other helpful browser extensions are: Unpaywall, Open Access Button & PaperPanda
For the infamous backdoor, use Sci-Hub – the pirated papers repository (Chrome extension here). This works better for older paper than the stuff that just came out.
Finally, email the author. They’re almost always happy to oblige because, thanks to the predatory academic publishing system, they don’t make a dollar off of their papers.
the Headlines & Fav Articles
Ugh. A woman in Oklahoma is being prosecuted for medical cannabis use during pregnancy. The state Supreme Court is being asked to step in & end the case
https://www.pregnancyjusticeus.org/press/pregnancy-justice-and-partners-ask-oklahoma-supreme-court-to-end-prosecution-of-pregnant-women-for-medical-marijuana-use/
Hats off to the continued fine work of Pregnancy Justice, an organization well deserving of your end-of-year donation dollars.
In Pennsylvania, medical cannabis growers & processors now allowed to sell products directly to patients
https://www.marijuanamoment.net/pennsylvania-governor-signs-bill-to-let-medical-marijuana-growers-sell-directly-to-patients-while-also-allowing-dispensaries-to-cultivate/
In Connecticut, alcohol sales are prohibited on Christmas & New Year’s Day – but cannabis dispensaries are open
https://www.marijuanamoment.net/connecticut-marijuana-retailers-can-open-on-christmas-and-new-years-but-alcohol-stores-must-close/
Probably good for harm reduction, but seems unfair.
In Ontario, the government has a monopoly on sending cannabis through the mail
https://nationalpost.com/news/canada/ontario-mail-order-cannabis-is-government-monopoly
To be fair, it is their mail.
Ha! In college basketball recruitment, you get a big boost from being in a legal cannabis state (but not so much for football)
https://www.marijuanamoment.net/states-that-legalize-marijuana-see-enhanced-college-basketball-recruitment-study-finds/
TD Cowen estimates that in the next five years, there will be 18 million more monthly cannabis consumers (with sales of $37B by 2027) & 2 million less alcohol consumers
https://www.marijuanamoment.net/marijuana-will-gain-millions-of-consumers-over-alcohol-with-sales-hitting-37-billion-by-2027-investment-bank-projects/?
In the cannabis industry, Whitney economics produces a survey on the “existential threat” of delinquent payments
https://www.prnewswire.com/news-releases/delinquent-payment-issue-represents-existential-threat-to-cannabis-industry-302015101.html
“The preliminary results of the survey are compelling.
43% of respondents stated that delinquent accounts receivables are impacting operators' ability to service their debt
32% of respondents stated that delinquent accounts receivables are impacting an operator's ability to pay state or federal taxes
59% of respondents reported that delinquent payments are having a greater impact on their business than federal tax policy 280E.
Some respondents indicated delinquencies were in excess of two months of revenue, totaled millions of dollars and that they needed to run their yearly operation on what amounted to 10 months of cash flow.
The delinquent payment issue has more acute impacts on cannabis operators since they generally do not have access to traditional financial tools such as bridge loans or loans against account receivables. As a result, predatory lending is pervasive with interest rates often running between 33% - 50%. Given the federal illegality of cannabis, operators do not have access to bankruptcy protection, so if a business fails, the result is individual wealth destruction.”
A Carnival Cruise spokesman denied that they enforce their strict ban on cannabis products in order to boost alcohol sales & that this "sounds like something someone would say when they're high"
https://www.marijuanamoment.net/carnival-cruise-lines-denies-that-anti-marijuana-enforcement-measures-are-meant-to-boost-alcohol-sales-on-ships/
When actually, that sounds pretty damn likely.
After surveying all the state & local film incentives for getting movies made in their location, only one of them had a restriction about reimbursements for cannabis purchases & none had penalties for tobacco or cannabis depictions
Descriptive cross-sectional survey of tobacco and cannabis restrictions on state and local film incentives in the USA
https://pubmed.ncbi.nlm.nih.gov/37989585/
The Dutch cities of Breda & Tilburg begin their experiments with selling legally grown cannabis
https://apnews.com/article/netherlands-coffeeshop-cannabis-pot-a313926f955339828175984054753a06
If you thought the Dutch have been doing this for decades, you'd be wrong. Their policy has been gedoogbeleid (“policy of tolerance”) where you're allowed to sell cannabis out of the front of a shop & they ask no questions about how it got into the back of the shop. However, this has led to no standards for quality & safety as well as organized crime moving in on unregulated cannabis growing. Overall, it seems likely that this system has led to the Netherlands losing its place to California as the leading producer of top-shelf cannabis.
A history of the recent fraught French fight for medical cannabis
https://businessofcannabis.com/2023-spotlight-frances-battle-for-medical-cannabis
This country 🙄… My bet is that I won’t be able to buy grass here until after my firstborn graduates high school. And her 6th birthday is next week.
That being said, thanks for the healthcare!
A Swiss study on alternatives to profit-maximizing commercial models of cannabis supply
Alternatives to profit-maximising commercial models of cannabis supply for non-medical use
https://policycommons.net/artifacts/8339224/alternatives-to-profit-maximising-commercial-models-of-cannabis-supply-for-non-medical-use/9269893/
And Bern is considering a pilot program with legal cocaine sales
https://www.reuters.com/world/europe/swiss-capital-bern-considers-legal-cocaine-project-2023-12-20/
In Malaysia, the opinion of Islamic jurists on the use of cannabis (translation required)
THE NECESSITY OF USING CANNABIS FOR MEDICAL HEALTH IMPORTANCE: A PRELIMINARY DISCUSSION
https://journal.unisza.edu.my/jimk/index.php/jimk/article/view/771/529
The Laws, The War on Drugs & the End of Prohibition
A kid who swallowed a vape pen cartridge because the cops were coming
Intentional Ingestion of Cannabis Vape Pen Cartridge: An Indication for Emergent Endoscopy
https://journals.lww.com/ajg/fulltext/2023/10001/s2983_intentional_ingestion_of_cannabis_vape_pen.284.aspx
A review of the effects of cannabis legalization by the Badger Institute finds either no impact or a beneficial impact on property & violent crime, a possible shrinking of the illicit market & a likely result in traffic fatalities or crashes
https://www.badgerinstitute.org/wp-content/uploads/2023/11/Badger-Institute-marijuana-legalization-and-the-impact-on-crime-231113.pdf
A review on using nail clippings for drug testing
Assessment of substance exposures in nail clipping samples: A systematic review
https://pubmed.ncbi.nlm.nih.gov/38041982/
According to Frazer in “The Golden Bough”, any wise magician never lets anyone access their nail clippings or other discarded bodily substances.
For traffic accidents, on the legalization of cannabis not increasing their levels
Legalizing Marijuana Hasn’t Made Roads Less Safe
https://qz.com/advisor/auto-insurance/has-marijuana-legalization-made-roads-less-safe/
A thesis project interviewing drug court professionals & their perspectives on cannabis legalization’s implication for the drug court system
Drug Court Professionals’ Perspectives on Marijuana Legalization Implications for the Drug Court System
https://www.proquest.com/openview/8312341fcf4ea52d905d32780e6c583a/1?pq-origsite=gscholar&cbl=18750&diss=y
Psychedelics, Plant Medicines & Other Psychoactives
The Psychoactive Research
[This isn’t a deep dive into the science of psychedelics & other psychoactives like I do for the cannabinoids. If your organization would be interested in a breakdown of all the new psychedelic science, reach out to me]
For PTSD, a case study of using 5-MeO-DMT
5-MeO-DMT for post-traumatic stress disorder: a real-world longitudinal case study
https://pubmed.ncbi.nlm.nih.gov/38076677/
The anti-suicidal effects of IV ketamine
Anti-suicidal effects of IV ketamine in a real-world setting
https://pubmed.ncbi.nlm.nih.gov/38064911/
Two case studies of using psilocybin for opioid use disorder
Psilocybin for Opioid Use Disorder in Two Adults Stabilized on Buprenorphine: A Technical Report on Study Modifications and Preliminary Findings
https://www.liebertpub.com/doi/abs/10.1089/psymed.2023.0012
And a review of psilocybin for substance use disorders & psychiatric conditions
The Tolerability and Safety of Psilocybin in Psychiatric and Substance-Dependence Conditions: A Systematic Review
https://pubmed.ncbi.nlm.nih.gov/37902038/
For people with cancer & depression, on psilocybin assisted group therapy
Psilocybin-assisted group therapy in patients with cancer diagnosed with a major depressive disorder
https://pubmed.ncbi.nlm.nih.gov/38105655/
and a review of psychedelics for treatment resistant depression
Psychedelics for treatment resistant depression: are they game changers?
https://pubmed.ncbi.nlm.nih.gov/37947195/
EEGs from people using psychedelics in natural settings & their reactions to facial emotions
The relation between naturalistic use of psychedelics and perception of emotional stimuli: An event-related potential study comparing non-users and experienced users of classic psychedelics
https://pubmed.ncbi.nlm.nih.gov/38069478/
An overview of MDMA for PTSD
MDMA-Based Psychotherapy in Treatment-Resistant Post-Traumatic Stress Disorder (PTSD): A Brief Narrative Overview of Current Evidence
https://pubmed.ncbi.nlm.nih.gov/37987270/
A review of using psychedelic in psychotherapy beyond reductionism
Treatment with psychedelics is psychotherapy: beyond reductionism
https://pubmed.ncbi.nlm.nih.gov/38101439/
The Plant & the History
A literature review for a sustainable hemp industry
Knowledge mapping for a secure and sustainable hemp industry: A systematic literature review
https://www.sciencedirect.com/science/article/pii/S2666016423002554
On improving the hemp supply chain in Finland
A system thinking approach to desirable changes in the supply chain of industrial hemp in Finland
https://nmbu.brage.unit.no/nmbu-xmlui/bitstream/handle/11250/3104425/no.nmbu%3Awiseflow%3A6907476%3A55526026.pdf?sequence=1
Growing & Farming
In Canada, a comprehensive review of the phenotypes of drug-type cannabis
Comprehensive Phenotypic Characterization of Diverse Drug-Type Cannabis Varieties from the Canadian Legal Market
https://pubmed.ncbi.nlm.nih.gov/37960111/
In medical cannabis plants, the dynamics of their mineral uptake
Dynamics of Mineral Uptake and Plant Function during Development of Drug-Type Medical Cannabis Plants
https://www.mdpi.com/2073-4395/13/12/2865
On finding the physiological traits of hemp related to drought tolerance & efficient water usage
Identifying physiological traits related with drought tolerance and water-use efficiency in floral hemp (Cannabis sativa L.)
https://acsess.onlinelibrary.wiley.com/doi/abs/10.1002/csc2.21150
In a vertical farming system, increased female hemp yield with the plant growth retardant diniconazole
Diniconazole Promotes the Yield of Female Hemp (Cannabis sativa) Inflorescence and Cannabinoids in a Vertical Farming System
https://www.mdpi.com/2073-4395/13/6/1497
Sprays of chitosan increased the yield of hemp
Impact of Chitosan-Based Foliar Application on the Phytochemical Content and the Antioxidant Activity in Hemp ( Cannabis sativa L.) Inflorescences
https://pubmed.ncbi.nlm.nih.gov/37960049/
On extending cannabis extract stability with a new ethanol-based extraction method
Medicinal Cannabis: Extended Stability of Cannabis Extracts Produced Using a New Ethanol-based Extraction Method
https://pubmed.ncbi.nlm.nih.gov/37963569/
A study of yields from extracting using dry ice & various solvents
Extraction, separation, and purification of cannabinoids from the Cannabis sativa L. plant using dry ice and solvents such as hexane and ethanol to determine the most efficient method
https://ieeexplore.ieee.org/abstract/document/10308993
On how the masculinization of female plants impacts pollen production & pollen fitness
Cosexuality Reduces Pollen Production and Fitness in Cannabis sativa L
https://pubmed.ncbi.nlm.nih.gov/37960087/
An analysis of phenolic contents of Estonian cannabis varieties
Extraction and Determination of Total Phenolic Contents, Flavonoid Contents, and Volatile Compounds in Epilobium angustifolium and Cannabis sativa Varieties
https://www.mdpi.com/2504-3900/92/1/21
In Punjab, the effects of lead toxicity & the resulting decreases in chlorophyll & carotenoids
Effect of Lead Toxicity on Wild Cannabis Species of Punjab Region
https://www.researchgate.net/publication/375747846_Effect_of_Lead_Toxicity_on_Wild_Cannabis_Species_of_Punjab_Region
On the hop latent viroid in Canada
Symptomology, prevalence, and impact of Hop latent viroid on greenhouse-grown cannabis (Cannabis sativa L.) plants in Canada
https://www.tandfonline.com/doi/pdf/10.1080/07060661.2023.2279184
In Thailand, the first leaf spot disease caused by the fungus Pseudocercospora cannabina
First Molecular Phylogenetic Identification and Report of Pseudocercospora cannabina Causing Leaf Spot Disease on Cannabis sativa in Thailand
https://www.mdpi.com/2311-7524/9/12/1261
A library of the cannabis virome
Cannabis Virome Reconstruction and Antiviral RNAi Characterization through Small RNA Sequencing
https://pubmed.ncbi.nlm.nih.gov/38068561/
Hemp as food
On creating a dairy snack to reduce weight containing oleoylethanolamide (an analog of anandamide)
Development of a functional dairy snack containing oleoylethanolamide that reduces food intake in normal-weight and obese minipigs
https://www.sciencedirect.com/science/article/pii/S1756464623005169
For poultry and & ruminants, a review on using dietary hemp & cannabinoids to modulate immune system responses
Potential of dietary hemp and cannabinoids to modulate immune response to enhance health and performance in animals: opportunities and challenges
https://pubmed.ncbi.nlm.nih.gov/38111585/
A thesis project in dairy cattle on the anti-inflammatory effects of the terpene beta-caryophyllene
Managing Inflammation Through Nutrition: An Investigation of Niacin, Cannabinoids, and Carbohydrates for Lactating Dairy Cattle
https://www.proquest.com/openview/4ae9b4f027812e9aa01af0d72de789f0/1?pq-origsite=gscholar&cbl=18750&diss=y
On improving hemp protein characteristics by forming a conjugate with a polysaccharide
Structural and Functional Characteristics of Hemp Protein Isolate-Pullulan Polysaccharide Glycosylation Conjugate in an Aqueous Model System
https://pubmed.ncbi.nlm.nih.gov/37048237/
Industrial Use
On the water absorption properties of hemp concrete
Multi-scale analysis of the effects of hysteresis on the hydrothermal behaviour of bio-based materials: Application to hemp concrete
https://www.sciencedirect.com/science/article/abs/pii/S0950061823038254
CANNABINOID SCIENCE
Reviews, Ingestion Methods & Public Health Data
In a poll of US adults between 50 & 80, 12% reported using cannabis in the last year & a third of those used four or more days per week
Prevalence and Frequency of Cannabis Use Among Adults Ages 50-80 in the United States
https://pubmed.ncbi.nlm.nih.gov/38010715/
And public health data showing increased cannabis use among a range of people with disabilities & health conditions
Trends in past-month cannabis use among US adults across a range of disabilities and health conditions, 2015-2019
https://pubmed.ncbi.nlm.nih.gov/37951542/
A survey of why people in Italy & here in France are using CBD (unfortunately the abstract doesn’t say much & the rest is behind a paywall)
Therapeutic Use and Other Reasons to Consume Cannabidiol: Insight from the French and Italian Contexts
https://www.tandfonline.com/doi/abs/10.1080/02791072.2023.2285843
People who vape cannabis also had a higher chance of using tobacco, alcohol, illicit drugs & to misuse prescription drugs
The association between cannabis vaping and other substance use
https://pubmed.ncbi.nlm.nih.gov/38058682/
#partiersgottaparty
An Iranian review of medical cannabis & its side effects
A Systematic Review of the Therapeutic Applications and Side Effects of Marijuana and Its Derivatives
https://sjfm.ir/article-1-1468-en.html
How THC & its metabolites move through the body after smoking
A Compartment Pharmacokinetics Model of THC and Its Metabolites after Smoking
https://www.mdpi.com/2673-4591/55/1/4
In rats, how two nanoemulsions of delta-8 THC move through their system
Pharmacokinetics of Two Nanoemulsion Formulations of Δ8-Tetrahydrocannabinol in Rats
https://pubmed.ncbi.nlm.nih.gov/37989959/
The Brain & Neurological Disorders
In people with epilepsy, those using recreational cannabis had lower intellectual reserves, reduced encoding of new information & enhanced susceptibility to distraction on a subsequent recall task
The impact of recreational cannabis use on neuropsychological function in epilepsy
https://pubmed.ncbi.nlm.nih.gov/37954009/
A computer study of CBD analogs for treating Alzheimer's disease
An In Silico Study for Expanding the Utility of Cannabidiol in Alzheimer's Disease Therapeutic Development
https://pubmed.ncbi.nlm.nih.gov/37959001/
Mental Health & Substance Use Disorders
A public health study from Italy found increased suicide attempts among people with cannabis use disorder who also identified as female, having alcohol use disorder or having any psychiatric diagnosis
Suicide Attempts in an Italian Population with Cannabis Use Disorders: Results of a Follow-Up Study
https://pubmed.ncbi.nlm.nih.gov/38009854/
In depressed patients, they had higher levels of anandamide & decreased levels of 2AG as well as gender differences in 2AG levels & anxiety levels
Genetic variation of the 5-HT1A rs6295, 5-HT2A rs6311, and CNR1 rs1049353 and an altered endocannabinoid system in depressed patients
https://onlinelibrary.wiley.com/doi/pdf/10.1002/brb3.3323
In brain scans of people recovered from cannabis-induced psychosis, they had no differences in their dopamine D2 receptor availability
A brain imaging study of dopamine receptor D2 availability in cannabis dependent users after recovery from cannabis-induced psychosis
https://pubmed.ncbi.nlm.nih.gov/37965367/
On looking for biomarkers to distinguish patients with schizophrenia, cannabis use disorder or dual diagnosis
Differential Serum Metabolomic Profile in Patients with Schizophrenia, Cannabis Use Disorder or Dual diagnosis
https://europepmc.org/article/ppr/ppr764054
A Saudi Arabian study of “cannabis addicts” & their vital signs before & after addiction treatment
Health status outcome among cannabis addicts after treatment of addiction
https://pubmed.ncbi.nlm.nih.gov/38011195/
In an animal model of schizophrenia, THC improved some behaviors that CBD didn't, but the CBD also protected from THC’s inflammation & shrinking of the corpus callosum (the bridge between the right & left brain)
THC improves behavioural schizophrenia-like deficits that CBD fails to overcome: a comprehensive multilevel approach using the Poly I:C maternal immune activation
https://pubmed.ncbi.nlm.nih.gov/38064909/
In a rat model of acute stress, the effects of the circadian rhythm on the endocannabinoid levels in their hippocampus, prefrontal cortex & amygdala
Circadian Influence on Acute Stress-induced Changes in Cortico-limbic Endocannabinoid Levels in Adult Male Rats
https://pubmed.ncbi.nlm.nih.gov/38006961/
In a mouse model of alcohol use disorder, a neutral antagonist of the CB1 receptor reduced their addictive behaviors
The neutral CB1 antagonist AM6527 reduces ethanol seeking, binge-like consumption, reinforcing, and withdrawal effects in male and female mice
https://pubmed.ncbi.nlm.nih.gov/38001264/
In rats, especially females, reduced social interactions were linked to lower levels of CB1 receptors & FAAH enzymes
Outcomes of early social experiences on glucocorticoid and endocannabinoid systems in the prefrontal cortex of male and female adolescent rats
https://www.frontiersin.org/articles/10.3389/fncel.2023.1270195/full
In male mice enduring chronic social isolation stress, they had a loss of CB1 receptors in their anterior cingulate cortex (important for cognition, motivation, decision making, learning, cost-benefit calculation, conflict & error monitoring)
CB1R dysfunction of inhibitory synapses in the ACC drives chronic social isolation stress-induced social impairments in male mice
https://pubmed.ncbi.nlm.nih.gov/37992714/
Reproduction & Hormones
Pregnant women with a history of serious psychological distress had greater rates of cannabis use, binge drinking & cigarette smoking
Exploring the associations between serious psychological distress and the quantity or frequency of tobacco, alcohol, and cannabis use among pregnant women in the United States
https://pubmed.ncbi.nlm.nih.gov/37951544/
Pain & Surgeries
In people with wrist fractures, those with cannabis use disorder had higher rates of developing medical complications as well as higher ER visits & readmission rates
Cannabis Abuse Is Associated With Greater Medical Complications, Emergency Department Visits, and Readmissions Following Open Reduction and Internal Fixation for Distal Radius Fractures
https://pubmed.ncbi.nlm.nih.gov/38006235/
In people who had back fusion surgery, those with cannabis use disorder had a greater chance of hospital readmission & revision surgery but a reduced risk of overall medical complications
Cannabis use Disorder and Complications After Anterior Cervical Diskectomy and Fusion
https://pubmed.ncbi.nlm.nih.gov/37956902/
In patients with coronary artery diseases, prebiotics & probiotics improve their endocannabinoid system tone, gut permeability & inflammatory biomarkers
Prebiotics Plus Probiotics May Favorably Impact on Gut Permeability, Endocannabinoid Receptors, and Inflammatory Biomarkers in Patients with Coronary Artery Diseases: A Clinical Trial
https://onlinelibrary.wiley.com/doi/pdf/10.1002/fsn3.3835
In flap reconstruction surgery & cannabis use, something must have happened (damn paywalls!)
Cannabis use and flap reconstruction: A propensity score matched analysis
https://onlinelibrary.wiley.com/doi/10.1002/micr.31038
The Guts, Metabolism, Oral Health & CHS
In women with inflammatory bowel disease, a survey showed that many were uncertain about the risks of cannabis use during pregnancy & the majority never discussed cannabis use with their providers
Perceptions and Prevalence of Cannabis Use in Women With Inflammatory Bowel Disease of Reproductive Age: A Cross-Sectional Study
https://academic.oup.com/jcag/advance-article/doi/10.1093/jcag/gwad049/7451108
In rats, a capsule of DHA & whey protein altered their endocannabinoid profile
Effect of Docosahexaenoic Acid Encapsulation with Whey Proteins on Rat Growth and Tissue Endocannabinoid Profile
https://pubmed.ncbi.nlm.nih.gov/37960275/
The Lungs
A French review on the pulmonary effects of inhaling cannabis
Pulmonary effects of inhaled cannabis
https://pubmed.ncbi.nlm.nih.gov/37966147/
The Genitourinary System
In rats, cannabis extracts protected the kidneys from a drug that causes nephrotoxicity
Therapeutic Effect of Lebanese Cannabis Oil Extract in the Management of Sodium Orthovanadate-Induced Nephrotoxicity in Rats
https://laur.lau.edu.lb:8443/xmlui/handle/10725/15160
The Skin
For wound healing, creating a film using CBD & 2-hydroxypropyl-β-cyclodextrin
In Vitro Wound Healing Potential of a Fibroin Film Incorporating a Cannabidiol/2-Hydroxypropyl-β-cyclodextrin Complex
https://pubmed.ncbi.nlm.nih.gov/38140022/
Cancer & Chemotherapy
In Illinois cancer patients, those with higher levels of pain were more likely to be using cannabis
Cannabis and Palliative Care Utilization among Non-Terminal Cancer Patients in the Illinois Medical Cannabis Program
https://www.mdpi.com/2813-1851/2/1/4
On using CBD & THC from Lebanese cannabis extracts to kill breast cancer cells
The Combination of CBD and THC Isolated from the Lebanese Cannabis sativa Exerts Anti-cancer Effects in Breast Cancer Cells
https://laur.lau.edu.lb:8443/xmlui/handle/10725/15127
Cool Chemistry & Tools
On creating metal nanoparticles from waste cannabis leaves for their anti-cancer & antibacterial effects
Synthesis of CeO2 nanoparticles from hemp leaf Extract: Evaluation of Antibacterial, anticancer and enzymatic activities
https://www.sciencedirect.com/science/article/pii/S1387700323014090
An overview of synthesis strategies for creating flavonoids & cannabinoids
Organocatalytic Enantioselective Syntheses of Flavonoids and Cannabinoids
https://onlinelibrary.wiley.com/doi/abs/10.1002/adsc.202301168
On the use of an enzyme & the cannabinoid scaffold to make new cannabinoids
Catalytic Potential of Cannabis Prenyltransferase to Expand Cannabinoid Scaffold Diversity
https://pubmed.ncbi.nlm.nih.gov/38010421/
On creating a nanoparticle of the flavonoid Cannabisin A
Hemp seed globulin-alginate nanoparticles for encapsulation of Cannabisin A with enhanced colloidal stability and antioxidant activity
https://pubmed.ncbi.nlm.nih.gov/38000582/
Thanks.
- lex
PS: For today’s percussion, the 1960 album by Terry Snyder & The All Stars called ‘Mister Percussion’. One of the leading percussionists of the Space-Age Pop era, he was a bandleader who worked with a variety of stars through the ‘50s, including being the favorite drummer of Perry Como. Check out the opening track with a cover of ‘Puttin’ on the Ritz’.
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