C&P#92: PEA for your brain + 🍃for very sick kids + smell & the ECS

Intl Narcotic Control Board not loving new cannabis laws

Mar 14, 2024

6 weeks of PEA improved cognition & memory + PEA for long COVID brain fog
Cannabinoids for children with serious diseases
Driving on medical cannabis seems not bad?
Your smell is tuned by endocannabinoids!
The complexities of cannabinoids & gut motility & GI health
No extra cavities from cannabis smoke + CBD for tootaches?

Hello everyone,

Welcome to the 92^nd edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science + assorted canna-news & psychedelic updates. On the cannabinoids, ask me anything.
Editor’s note: Sorry to be late this week. Had an urgent research request. Plus kids with the plague.

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My work this week:

Canna-Education for CV Sciences:
(TikTok:@cvsciences or my YouTube playlist 3-minute Cannabinoid Science)

My TikToks:
(@lexpelgerandhisbooks or on YouTube)

'Giordano Bruno Philosopher / Heretic' by Ingrid D Rowland (words do not do this book justice)
Witchy Women Books for International Women's Day
Sex Worker Rights are Human Rights
Fred Roger's Rules for Explaining Things to Children
Books for toddlers
The Secret Doctrines of Tibet via Evans-Wentz
#2 & #3 on Tree of Life with the Tarot elements
poem: 'The Lesson of the Moth' by Don Marquis
Opening the 33rd box of Uncle Buck's Books (a special treasure found at the end)

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The Canna-Science Writeup:
Analysis of the week's best papers, sponsored by CV Sciences

In healthy adult, six weeks of 700 milligrams of PEA per day significantly increased scores on a memory test as well as levels of BDNF (a key brain growth factor for neural plasticity)
Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial
https://pubmed.ncbi.nlm.nih.gov/38398813/
Want to be the smartest person in the room? Want to memorize π to a few hundred digits? Cognition got you down? Try PEA!
I might have missed my calling writing ads for used car lots – but this PEA study sells itself. With 39 participants in this double-blind placebo-controlled crossover trial, for six weeks the researchers gave them 700 mg of Levagen+ PEA (the same source as in our Relief product) per day. Before starting the trial, the participants gave serum samples and took a battery of cognition tests. After the six weeks, the ones getting PEA scored significantly higher on the memory test than those getting the placebo, though no changes to attention or psychomotor speed. In addition, the PEA caused their blood to have increased levels of BDNF (brain-derived neurotrophic factor – a key protein for brain plasticity). As the researchers state, “these findings lay the foundations for formulated PEA (Levagen+®) to be considered an effective nootropic supplement that can be used by populations to support academic study and by the wider general public to improve cognition.”
To see all the research ever done on this endocannabinoid-like molecule, see the PEA page of CVResearch.info.

In people with brain fog after COVID, PEA & luteolin (an antioxidant flavonoid often paired with PEA) caused significant improvement to their scores & 80% of the patients reported improvements
Co-ultraPEALut in Subjective Cognitive Impairment Following SARS-CoV-2 Infection: An Exploratory Retrospective Study
https://www.preprints.org/manuscript/202402.0544/v1
In this retrospective study, the researchers compared controls with brain fog from long COVID against 26 similar patients who also took a combination of 700 mg of PEA + 70 mg of luteolin (an antioxidant flavonoid often paired with PEA) for at least two months. From their first neurological evaluation, the patients taking PEA+lut showed significant improvements, especially in their memory and cognition scores. Fatigue scores also improved, although not to statistical significance. Out of these 26 patients, 16 reported a reduction of their symptoms, 5 reported a complete remission, 4 reported that they remained stable, and only one reported worsening symptoms. Interestingly, the PEA+lut patients who were also getting corticosteroids did no better than those who weren’t getting them (except for fatigue). The researchers guess that the benefits of the PEA+lut powerhouse is due to its anti-inflammatory properties against the neuroinflammation of long COVID.

In patients with insomnia, cannabis medicine caused an improvement in sleep quality
UK Medical Cannabis Registry: Assessment of clinical outcomes in patients with insomnia
https://pubmed.ncbi.nlm.nih.gov/38337193/
Another helpful study from the UK Medical Cannabis Registry. In a case series of 61 patients with insomnia, they followed them for up to six months after the initiation of cannabinoid-based medicines. They were prescribed CBD or THC oil, CBD or THC flower, or a combination (see the table here). About half the participants experienced clinically significant improvements on their Sleep‐Quality Scale, their Generalized Anxiety Disorder score, and/or their quality-of-life scores (the EQ-5D-5L, covering mobility, self-care, usual activities, pain/discomfort, and anxiety/depression). This lines up with all the anecdotes saying that while cannabinoids don’t help everyone’s sleep, for a large subset of people, they make a game-changing difference.
Get the Sleep Gummies of PlusCBD to help you sleep.

Best Of Cannabinoid Science...

In an analysis of 35 CBD products, only 33% matched the content on their label
CBD products: Labeling accuracy of an obscure niche market
https://www.sciencedirect.com/science/article/pii/S0956713524000926
Get your CBD from someone with third-party testing. Such as PlusCBD…
Coupon code LEX for 30% off.

Clinical

In children with alternating hemiplegia (a rare neurological disorder causing temporary loss of muscle tone on one side of the body), CBD worked as well as the standard treatment of flunarizine (a calcium antagonist) for efficacy & CBD did better for control of seizures
Real life retrospective study of cannabidiol therapy in alternating hemiplegia of childhood
https://pubmed.ncbi.nlm.nih.gov/38367370/

In a pediatric palliative care center, the majority of the patients saw improvement from cannabinoids
The Use of Cannabinoids in Pediatric Palliative Care-A Retrospective Single-Center Analysis
https://pubmed.ncbi.nlm.nih.gov/38397346/
“Thirty-one patients with a primary diagnosis of neuropediatric, oncologic, metabolic, and cardiologic categories were included. The indications we identified were spasticity, pain, restlessness, anxiety, loss of appetite, epilepsy, and paresis. Certain aspects of quality of life were improved for 20 of 31 patients (64.5%). For nine patients (29%), no improvement was detected. No conclusions could be drawn for two patients (6.5%). Adverse events were reported for six of the thirty-one patients (19.4%). These were graded as mild, including symptoms such as restlessness, nausea, and behavioral issues. We detected no clinically relevant interactions with other medications.”

No association between dental cavities & cannabis smoking
The Effect of Marijuana-Smoking on Dental Caries Experience
https://pubmed.ncbi.nlm.nih.gov/38355392/
And considerations around using CBD for toothaches
Cannabidiol for Toothache: Ups, Downs, and Regulatory Considerations
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10900851/

In Poland, a survey of why people use CBD
Cannabidiol usage, efficacy, and side effects: analyzing the impact of health conditions, medications, and cannabis use in a cross-sectional online pilot study
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1356009/full
“The top five reasons for using CBD were self-reported stress (65.3%), sleep problems (51.7%), overall improvement in well-being (52.5%), improved mood (44.9%), and anxiety relief (40.9%). Our findings suggest that individuals with psychiatric disorders and those taking psychotropic medications are more likely to use CBD to relieve stress and anxiety. Overall, nearly 70% of the individuals found CBD products to be effective.”

Two case reports of psychosis caused by HHC
HHC-induced psychosis: a case series of psychotic illness triggered by a widely available semisynthetic cannabinoid
https://pubmed.ncbi.nlm.nih.gov/38351841/

Reviews

A review of using CBD for trigeminal neuralgia (chronic pain involving the nerve of the face)
Trigeminal Neuralgia and Cannabidiol Approach
https://preprints.aijr.org/index.php/ap/preprint/view/516

For PTSD & comorbid cannabis use disorder, a negative-slanting review of 14 studies
A Systematic Review of the Clinical Effects of Cannabis and Cannabinoids in Posttraumatic Stress Disorder Symptoms and Symptom Clusters
https://pubmed.ncbi.nlm.nih.gov/38353645/

A review of 13 studies on the GI symptoms of cannabis
Cannabis induced gastrointestinal tract symptoms in the adult population: a systematic review
https://pubmed.ncbi.nlm.nih.gov/38198773/
“Twelve out of the thirteen included studies reported some type of gastrointestinal tract symptoms experienced in medical and/or recreational cannabis users ranging from nausea, vomiting, diarrhoea, abdominal pain, to adult intussusception.”

For gut health, the complicated effects of cannabinoids on gastric motility, gastroparesis & the microbiome
Got the Munchies for an Egg Sandwich? The Effects of Cannabis on Bowel Motility and Beyond
https://pubmed.ncbi.nlm.nih.gov/38443102/

For heart health, a review of the effects of the cannabinoids (with charts)
How do phytocannabinoids affect cardiovascular health? An update on the most common cardiovascular diseases
https://pubmed.ncbi.nlm.nih.gov/36636553/

A review of the derived cannabinoid market after the Farm Bill
Cannabidiol-Derived Cannabinoids: The Unregulated Designer Drug Market Following the 2018 Farm Bill
https://pubmed.ncbi.nlm.nih.gov/38352661/

A review of the furanoid cannabinoids like CBE & CBF
Chemistry and pharmacological aspects of furanoid cannabinoids and related compounds: Is furanoid cannabinoids open a new dimension towards the non-psychoactive cannabinoids?
https://pubmed.ncbi.nlm.nih.gov/38417219/

Preclinical

Our olfactory perception tuned by the endocannabinoids!
Endogenous cannabinoids in the piriform cortex tune olfactory perception
https://pubmed.ncbi.nlm.nih.gov/38336844/

In a mouse model of lead toxicity, CBD lowered inflammation & decreased toxic effects in the liver, kidney & testes
Evaluation of the protective effect of cannabidiol in lead toxicity in mice
https://assets.researchsquare.com/files/rs-3936708/v1/f207a891-1135-441d-81bb-d2667f36d572.pdf?c=1707767310

On how endocannabinoids alter membrane fluidity
Examining endocannabinoid effects on membrane fluidity
https://www.cell.com/biophysj/abstract/S0006-3495(23)01372-3

An evergreen note on reading restricted papers:
First stop for seeing if there’s a free version of a paper, use the Google Scholar Chrome extension (Mac version), Google Scholar itself or try ResearchGate.
Three other helpful browser extensions are: Unpaywall, Open Access Button & PaperPanda
For the infamous backdoor, use Sci-Hub – the pirated papers repository (Chrome extension here). This works better for older paper than the stuff that just came out.
Finally, email the author. They’re almost always happy to oblige because, thanks to the predatory academic publishing system, they don’t make a dollar off of their papers.

the Headlines & Fav Articles

For your best daily cannabis news source: Marijuana Moment

Surprise! The International Narcotics Control Board not jazzed at so many countries liberalizing their cannabis laws
https://www.marijuanamoment.net/un-body-reaffirms-that-marijuana-legalization-violates-international-treaties-while-addressing-germany-cannabis-reform-and-u-s-psychedelics-movement/

In Canada, cannabis legalization linked to an immediate decline in beer sales
https://www.marijuanamoment.net/marijuana-legalization-linked-to-decline-in-beer-sales-indicating-substitution-effect-canadian-study-finds/

In Malta, the first month of cannabis clubs saw 750 people join
https://timesofmalta.com/article/750-people-join-cannabis-clubs-first-month-previous-users.1087552
Seems… low?

Despite a recall, SF cannabis shops selling vapes containing a banned pesticide (solid reporting by Lester Black & SFGate)
https://www.sfgate.com/cannabis/article/california-urges-public-check-cannabis-packages-18602947.php

The Laws, The War on Drugs & the End of Prohibition

For driving, a naturalistic study finds medical cannabis to have a negligible impact on driving performance
A semi-naturalistic open-label study examining the effect of prescribed medical cannabis use on simulated driving performance
https://pubmed.ncbi.nlm.nih.gov/38332655/

In Canada, analysis of a roadside oral fluid screening device for THC levels
Evaluation of the Canadian Approved Drug Screening Equipment cut-off levels for Tetrahydrocannabinol (THC)
https://pubmed.ncbi.nlm.nih.gov/38343275/

On the amount of water California is using for illegal vs legal cannabis grows
Water Use: Cannabis in Context
https://kymkemp.com/wp-content/uploads/2024/02/CRC_Brief_WaterUse_2024.pdf

The Plant & the History

Growing & Farming

On the efficacy of plant biostimulants & mycorrhiza applications on growth
The effects of plant biostimulant and mycorrhiza applications on industrial hemp (Cannabis sativa L.) growth and phytoremediation performance
https://cms.gnest.org/sites/default/files/Proceedings/cest2023_00480/cest2023_00480.pdf

In cannabis triploids (three copies of their genome), they had lower seed production & reduced fertility (which could be good if you’re worried about pollen exposure)
Cannabis Triploids Exhibit Reduced Fertility and Similar Growth and Flower Production Compared to Diploids
https://journals.ashs.org/jashs/view/journals/jashs/149/2/article-p75.xml

On the effects of the methyl jasmonate genes on trichome formation
Deep learning-based quantification and transcriptomic profiling reveal a methyl jasmonate-mediated glandular trichome formation pathway in Cannabis sativa
https://pubmed.ncbi.nlm.nih.gov/38332528/

Hemp does not appear to be a host for the potato cyst nematode Globodera pallida
HOST STATUS AND HATCHING EFFECT OF HEMP (CANNABIS SATIVA) AND TEFF (ERAGROSTIS TEF) ON GLOBODERA PALLIDA
https://journals.flvc.org/nematropica/article/view/135163

On ways to improve the zinc phytoremediation ability of cannabis
The effect of chelating agents on the Zn-phytoextraction potential of hemp and soil microbial activity
https://chembioagro.springeropen.com/articles/10.1186/s40538-024-00544-6

On the effects of microwave infrared drying
Microwave-infrared drying of cannabis (Cannabis sativa L.): Effect on drying characteristics, energy consumption and quality
https://www.sciencedirect.com/science/article/pii/S0926669024001924

Hemp as Food

In steers, a feed of hempseed cake decreased their organic matter digestibility but improved their nitrogen utilization, suggesting it as a useful alternative feed
Effects of hempseed cake on ruminal fermentation parameters, nutrient digestibility, nutrient flow, and nitrogen balance in finishing steers
https://pubmed.ncbi.nlm.nih.gov/36592747/

Industrial Use

On using hemp as an eco-friendly material for heritage conservation, based on the 1500 years of the earthen plaster of Ellora
Cannabis sativa (hemp) – an eco-friendly material for heritage conservation and sustainable environment
https://www.emerald.com/insight/content/doi/10.1108/JCHMSD-12-2022-0206/full/html

For preparing hemp to be made into paper, the efficacy of alkaline pretreatment & soda pulping
Alkaline pretreatment and soda pulping of genetically improved hemp
https://www.sciencedirect.com/science/article/abs/pii/S0926669024001614

CANNABINOID SCIENCE

A review of the mechanisms & therapeutic targets of cannabis
Medical cannabis: Mechanisms of action and therapeutic targets
https://www.researchgate.net/publication/378163454_Medical_cannabis_Mechanisms_of_action_and_therapeutic_targets

Public Health

In Australia, a survey of the differences in medical cannabis usage
Differences in prescribed medicinal cannabis use by cannabinoid product composition: Findings from the cannabis as medicine survey 2020 (CAMS-20) Australia-wide study
https://pubmed.ncbi.nlm.nih.gov/38354169/
“Participants prescribed THC-dominant MC products were statistically more likely to be younger, male, and to prefer inhaled routes of administration than participants using CBD-dominant products who were older, female, and preferred oral routes of administration. Pain and mental health were the most common reasons for all types of prescribed MC, but were more likely to be treated with THC than CBD despite the significantly higher risk of mild to severe drowsiness, dry mouth and eye irritation. Consumer reported effectiveness of prescribed MC was very positive, particularly for THC-containing products. Consumers on opioids and antipsychotics were statistically more likely to be prescribed THC-containing products than products containing CBD only, despite the greater risk of impairment.”

In medical cannabis patients, the simultaneous use of cannabis & alcohol
Simultaneous Cannabis and Alcohol Use among Medical Cannabis Patients
https://pubmed.ncbi.nlm.nih.gov/38343069/

In Canada after legalization, legal stores were evenly spread across economic neighborhoods but not social
Distribution of legal retail cannabis stores in Canada by neighbourhood deprivation
https://pubmed.ncbi.nlm.nih.gov/38351142/
“The distribution of stores was closely aligned with the expected distribution across levels of material deprivation: for example, 19.5% of stores were located in neighbourhoods with the lowest level of material deprivation versus 19.1% in the highest level. More cannabis stores were located in the 'most socially deprived' or 'socially deprived' neighbourhoods (37.2% and 22.1%, respectively), characterized by a higher proportion of residents who live alone, are unmarried, or in single-parent families.”

Adolescents & Young Adults

Early puberty linked to increased alcohol & cannabis use
Concurrent and long-term effects of early pubertal timing on alcohol, cigarette, and cannabis use from adolescence to adulthood
https://psycnet.apa.org/record/2024-52155-001

The Brain & Neurological Disorders

New variants of THCO for treating neuropathologies
Synthesis and Evaluation of Natural and Unnatural Tetrahydrocannabiorcol for Its Potential Use in Neuropathologies
https://pubmed.ncbi.nlm.nih.gov/38355400/

In neurosphere cultures, high levels of CBD were neurotoxic
High Concentrations of Cannabidiol Induce Neurotoxicity in Neurosphere Culture System
https://pubmed.ncbi.nlm.nih.gov/38349488/

Mental Health & Substance Use Disorders

A thesis on severe mental disorders & the effects of cannabis use on negative symptoms
Negative symptoms and cannabis use in severe mental disorders. Weeding out important links and outcomes across diagnoses and time
https://www.duo.uio.no/handle/10852/107912
“Both baseline- and persistent cannabis use predicted enduringly higher levels of diminished expression over a 10-year period after the first episode of psychosis, compared to non-use. There was no significant link between cannabis use and apathy, and no link to either dimensions of negative symptoms in bipolar disorders, suggesting that disorders on the more severe end of the psychosis spectrum are more vulnerable to the effects of cannabis. The differences in association between cannabis use and the two negative symptom dimensions show that they respond differently to cannabis exposure, which may indicate that the underlying pathophysiological mechanisms of diminished expression and apathy are divergent.”

Reproduction & Hormones

In a mouse model of prenatal cannabis smoke exposure, the offspring saw significant changes to the endocannabinoid system of their guts
A200 EXPOSURE TO CANNABIS SMOKE IN UTERO AFFECTS THE DEVELOPMENT OF THE ENDOCANNABINOID SYSTEM IN THE GASTROINTESTINAL TRACT
https://academic.oup.com/jcag/article/7/Supplement_1/157/7607392

Pain & Surgeries

In people undergoing colon surgery, cannabis use disorder was not associated with an increased risk of negative outcomes
Prevalence of cannabis use disorder and perioperative outcomes in adult colectomy patients: A propensity score-matched analysis
https://pubmed.ncbi.nlm.nih.gov/38342773/

Musculoskeletal & Exercise

In mice calf muscles, how the CB1 receptor altered the dynamics & composition of their mitochondria (powerhouse of the cell)
Effect of CB1 Receptor Deficiency on Mitochondrial Quality Control Pathways in Gastrocnemius Muscle
https://pubmed.ncbi.nlm.nih.gov/38392333/

For human bone cells, CBD & THC caused different effects at different dosages
Human osteoclasts in vitro are dose dependently both inhibited and stimulated by cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC)
https://pubmed.ncbi.nlm.nih.gov/38342278/

The Guts, Metabolism, Oral Health & CHS

In a male rat model of social stress, inhibiting the FAAH enzyme (thus raising anandamide levels, also a function of CBD) blocked depressive behaviors, neuroendocrine changes & alterations in gut microbial & lipid composition
Social stress-induced depressive-like symptoms and changes in gut microbial and lipidomic profiles are prevented by pharmacological inhibition of FAAH activity in male rats
https://pubmed.ncbi.nlm.nih.gov/38354897/

In a mouse model of colitis, activating the CB2 receptor lowered colonic pain & combined well with morphine as a painkiller
A7 CANNABINOID 1 AND 2 RECEPTOR AGONISTS AND MU-OPIOID RECEPTOR AGONISTS SYNERGISTICALLY INHIBIT COLONIC NOCICEPTION DURING ACUTE COLITIS
https://academic.oup.com/jcag/article/7/Supplement_1/4/7607402

In a mouse model of obesity-mediated insulin resistance, the hormone resistin regulated inflammation & insulin resistance via the endocannabinoid system
Resistin Regulates Inflammation and Insulin Resistance in Humans via the Endocannabinoid System
https://spj.science.org/doi/pdf/10.34133/research.0326

In human oral cells, very high levels of CBD caused toxic effects
Acute and chronic cannabidiol treatment: In vitro toxicological aspects on human oral cells
https://pubmed.ncbi.nlm.nih.gov/38342230/

The Immune System & Antimicrobial

In people living with HIV, cannabis use was associated with lower plasma lipopolysaccharide binding protein, but no other changes in this panel of inflammation markers
Cannabis Use and Biomarkers of Inflammation, Immune Activation, and Microbial Translocation in Persons with HIV
https://pubmed.ncbi.nlm.nih.gov/38335314/

An assay to study the effects of the cannabinoids on T cells
Development of an in vitro peptide-stimulated T cell assay to evaluate immune effects by cannabinoid compounds
https://pubmed.ncbi.nlm.nih.gov/38335658/

The Lungs

A lung cell safety study of the derived cannabinoid products
Comprehensive Safety Assessment of Diverse Cannabinoids: A Scientific Inquiry
https://assets.researchsquare.com/files/rs-3934959/v1/d7aa8c75-edac-4c61-93d5-3c5efd29f63a.pdf?c=1707380621

Cancer & Chemotherapy

For non-small cell lung cancer cells, on the antitumor effects of CBD + cytokine-induced killer cells
Discovering single cannabidiol or synergistic antitumor effects of cannabidiol and cytokine-induced killer cells on non-small cell lung cancer cells
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1268652/abstract

In breast cancer cells, how the endocannabinoid anandamide (AEA) & the paracannabinoid lysophosphatidylinositol (LPI) cause cell death
The Interaction of the Endocannabinoid Anandamide and Paracannabinoid Lysophosphatidylinositol during Cell Death Induction in Human Breast Cancer Cells
https://pubmed.ncbi.nlm.nih.gov/38396948/

Synthetic Cannabinoids

A German report on ADB-HEXINACA
ADB-HEXINACA-a novel synthetic cannabinoid with a hexyl substituent: phase I metabolism in authentic urine samples, a case report and prevalence on the German market
https://pubmed.ncbi.nlm.nih.gov/38350637/

A review on the effects of the synthetic cannabinoids
BEYOND THE HIGH: CBD AND THC IN THE ERA OF DESIGNER DRUGS
https://www.researchgate.net/publication/377968811_BEYOND_THE_HIGH_CBD_AND_THC_IN_THE_ERA_OF_DESIGNER_DRUGS

Cool Chemistry & Tools

A review of methods to improve CBD bioavailability
Strategies to Improve Cannabidiol Bioavailability and Drug Delivery
https://pubmed.ncbi.nlm.nih.gov/38399459/

The molecular dynamics of the CB1 receptor,
Differential behavior of conformational dynamics in active and inactive states of cannabinoid receptor 1 revealed by microsecond molecular dynamics simulation
https://www.cell.com/biophysj/abstract/S0006-3495(23)00911-6
An analysis of selectivity & bias for binding at the CB1 receptor
Investigating selectivity and bias for G protein subtypes and β-arrestins by synthetic cannabinoid receptor agonists at the cannabinoid CB1 receptor
https://pubmed.ncbi.nlm.nih.gov/38354957/
And a library of CB1 agonists
Large library docking for cannabinoid-1 receptor agonists with reduced side effects
https://pubmed.ncbi.nlm.nih.gov/38328157/

New modulators of the CB2 receptor
Discovery and development of macrocyclic peptide modulators of the cannabinoid 2 receptor
https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/65ba01cb9138d2316119b40b/original/discovery-and-development-of-macrocyclic-peptide-modulators-of-the-cannabinoid-2-receptor.pdf

Thanks.
- lex

PS: For today’s swinging guitar of Argentina, Oscar Alemán’s ‘Hombre Mio the Master of Swing Guitar’. In 1919, after being orphaned at the age of 10, Alemán supported himself by playing music on the street & bought a guitar for playing at parties. By 1925, he was playing in Buenos Aires, soon followed by a world tour. He decided to stay in Madrid where he discovered American jazz. Then Josephine Baker hired him to lead her band at the Café de Paris. He was a great friend of Django Reinhardt, but indeed, despite being one of the best swing guitar players of the ‘30s, the gypsy jazz of Django would always overshadow Alemán’s work. But he toured Europe with Louis Armstrong & Duke Ellington before returning to local fame in Argentina. You can see the documentary ‘Oscar Aleman: Vida Con Swing’ about his life.

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Cannabinoids & the People