C&P#95: CBD for menstrual relief & TMDs + cannabis for migraines & PEA for neuropathic pain
C&P#95: CBD for menstrual relief & TMDs + cannabis for migraines & PEA for neuropathic pain
Germany legalizes & the UN endorses harm reduction
This week…
CBD for menstrual symptoms!
Migraine patients endorse cannabis
A special section on exercise
CBD for facial pain (temporomandibular disorders) in humans
PEA for chronic neuropathic pain
CBD for neuroinflammation, TBIs, inflamed prostates, epilepsy, insecticide exposure & toxic doses of nicotine (animal models)
New guidelines for CHS
On the structural birth defects linked to prenatal cannabis exposure
Proof of retrograde endocannabinoid signaling
A new cannabis molecule: welcome methoxy canniprene!
3 on ketamine for treatment-resistant depression
Hello everyone,
Welcome to the 95th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science + assorted canna-news & psychedelic updates. On the cannabinoids, ask me anything.
For more…
Subscribe here: upgrade to a paid subscription to support my work sharing cannabinoid science
Work with my company White Whale Creations to produce content for cannabis & psychedelic companies: writing, science archives, social media content, newsletters & podcasts: My portfolio
Buy ‘SUNset’: my Queer cannabis history graphic novel or check out the rest of my graphic novel series about cannabis & the endocannabinoid system based on Moby Dick
Free resources (my Linktree)
See the extensive cannabinoid science archive I maintain for CV Sciences at CVResearch.info
Read my free How-To Guides or watch my 3-Minute Cannabinoid Science videos on YouTube / TikTok / Instagram or read my canna-science journalism here
Socials: LinkedIn, Facebook, Threads & Twitter & my personal TikTok on books, hermeticism, science & history
As always, here’s the Glossary of Cannabinoid Terms & at the bottom is the album of the week
A request to spread the word
This newsletter only spreads by word of mouth,
so please forward to colleagues & tell your friends & relatives.
Sponsored by PlusCBD Pet Chews
I’m proud to announce the new PlusCBD Pet Chews (as in your pet chews on them, they don’t chew on your pet).
With two different types (Calming Care + Hip & Joint Health), they’re a delightful way to get CBD plus a host of other helpful ingredients into your canine companion.
Calming Care Pet Chews combine CBD with proven calming ingredients to help keep your pet relaxed and even tempered, even when experiencing stressful situations like changing schedules, new additions to the household, and loud noises like fireworks.
Chamomile 50 mg: By soothing nerves and promoting calm, chamomile can help anxious dogs feel more at ease in stressful situations without causing drowsiness.
L-Tryptophan 30 mg: A precursor to serotonin, L-tryptophan can aid in promoting a sense of calm and relaxation in dogs by supporting neurotransmitter balance in the brain.
Ginger Root 30 mg: Ginger root possesses natural calming properties in dogs to reduce effects of stress and help foster a healthier emotional state.
L-Theanine 30 mg: L-Theanine increases the production of calming neurotransmitters such as dopamine and serotonin in the brain. By reducing stress levels, L-Theanine can help dogs feel more relaxed and content.
Hip and Joint Health Chews can help alleviate joint stiffness and pain and increase mobility and comfort with a blend of CBD and soothing ingredients for joint health. That means extra games of fetch, longer walks, and more trips to the dog park.
Glucosamine HCL 500 mg: Glucosamine HCL is a vital supplement for maintaining joint health in dogs, as it supports the production of cartilage and lubricates the joints, helping to alleviate pain and improve mobility in dogs with joint-related issues.
Turmeric 300 mg: Turmeric serves as a potent natural anti-inflammatory agent for dogs, effectively reducing joint inflammation and alleviating pain associated with conditions like arthritis. Its antioxidant properties further contribute to joint health by protecting against oxidative stress.
Rosehips 200 mg: Rosehips are rich in vitamin C and other antioxidants, which help support joint health in dogs by reducing inflammation and promoting collagen production for cartilage repair.
Ginger Root 30 mg: Ginger root contains anti-inflammatory properties that can help alleviate joint pain and stiffness in dogs and increase mobility and comfort, making it a natural supplement for promoting joint health.
Try the new CBD-infused Calming Care and Hip & Joint Health & use the coupon code LEX for 30% off.
And here’s my list of recent dog videos:
My work this week:
Canna-Education for CV Sciences:
(TikTok:@cvsciences or my YouTube playlist 3-minute Cannabinoid Science)
Canna for Wound Healing (10k+ views)
Worldwide Canna-Report #11 : Colombia @ the UN +Morocco's haul + Zurich's experiment
History:
The Druids & Our Favorite PlantThe Ancient Greco-Roman Doctors & Our Favorite (quite proud of this 9’ history, but the algo didn’t even show it to 500 people)
My TikToks:
(@lexpelgerandhisbooks or on YouTube)
My Second Graphic Novel! (about to republish my second book. DM to review the PDF of the proof)
The Purpose of this Channel (it’s my kids in 15 years)
'The Thrilling Adventures of Lovelace & Babbage' by Syndey Padua
The Genius of Rod Serling & the Importance of the Twilight Zone
Uncle Buck's Library - Box #34 (some delights discovered)
Groucho Marx sez... (a funny joke)
Ways to support this work:
A paid subscription on Substack
Buy Me a Coffee
Venmo: @Lex-Pelger
PayPal: donate here
The Canna-Science Writeup:
Analysis of the week's best papers, sponsored by CV Sciences
#MENUSTRATION
In people with menstrual-related symptoms, CBD reduced symptoms, irritability, anxiety, stress & subjective severity scores
Examination of the Effects of Cannabidiol on Menstrual-Related Symptoms
https://psycnet.apa.org/fulltext/2024-61679-001.pdf
Despite the use of cannabis for menstrual relief going back to ancient China, Egypt of the 15th century BCE, and Assyria of the 7th century BCE and despite the fact that “75% of menstruating individuals experience unpleasant menstrual-related symptoms”, there’s never before been a clinical study of cannabinoids for menstrual-related symptoms until this week.
In this open-label trial of 30+ people with menstrual-related symptoms, the participants received either 160 mg or 320 mg of CBD isolate twice a day, to be begun when the first symptoms of the month appear and then to continue to take their CBD for 5 days. After three months, the participants in both groups reported lower levels of menstrual-related symptoms, irritability, anxiety, global impression of change, stress, and subjective severity scores. The only measurement unchanged was depression. Notably, the beneficial effects were felt in the first month and continued throughout the duration of the study. For more on menstrual symptoms, check out both the Hormones & Reproductive Systems page and the PEA page of CVResearch.info.
Fun fact: Sir John Russel Reynolds, personal physician to Queen Victoria and one of the leading doctors of his age, sung the praises of cannabis (Indian hemp) as being of “great service in cases of simple spasmodic dysmenorrhea [period pain]”. However, it’s now considered unlikely that he ever prescribed any to his royal charge.
#TMDs
In patients with temporomandibular disorders (pain issues of the face region), CBD reduced pain, muscle tension & bruxism (teeth grinding during sleep)
Cannabidiol Intervention for Muscular Tension, Pain, and Sleep Bruxism Intensity—A Randomized, Double-Blind Clinical Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932451/
Temporomandibular disorders (TMDs) actually refer to a group of more than 30 conditions that cause pain throughout the jaw joints and jaw muscles. Centered on the joints that hinge your jaw, they can include disorders of the muscles for chewing, disorders of the joints, or headaches. The symptoms vary greatly but can include pain while chewing or using the jaw, tooth pain, stiffness or locking of the jaw, painful clicks when opening or closing the mouth, pain that spreads to the face or neck, ringing in the ears or hearing loss, and dizziness. Unless there was a clear injury to the jaw or the person has bruxism (grinding of the teeth during sleep), the cause of each person's TMD tends to be a mystery. In addition, there are few good treatments. Experts typically warn against surgeries because it doesn’t seem to be caused by misalignments and the non-surgical treatments are simply eating softer foods, applying heat or cold, strengthening or stretching the jaw muscles, mouth splints, and taking ibuprofen. And the pain, discomfort, and inconvenience for people can be extreme.
In this study of 60 patients, the researchers used a placebo-controlled double-blind clinical trial with three different arms: a control group, a group receiving 5% CBD, and a group receiving 10% CBD. After a month of treatment, the patients were measured by a variety of tests. The group receiving the 10% CBD saw a more than 50% reduction in their pain scores, a 50% reduction in their bruxism, and a ~40% reduction in their muscle activation (surface electromyography). The 5% group also saw improvements, but they weren’t as strong. Plus, “none of the patients in the study groups reported experiencing side effects from the products.” Similarly, a few years ago a topical CBD study of TMD also found positive results. #CBD4TMD
#MIGRAINES
In a survey of 1300+ people from a tertiary headache center, they reported using cannabis to treat their headaches & sleep concerns with the majority reporting improvements in migraine intensity, duration & frequency as well as nausea, sleep disturbances, anxiety & depression
Characterizing Cannabis Use and Perceived Benefit in a Tertiary Headache Center Patient Sample
https://www.neurology.org/doi/abs/10.1212/CPJ.0000000000200285
As I get older, I believe I'm starting to see surveys - and not double-blind clinical trials - as the epitome of evidence. Clinical trials are rigid and often underpowered. Surveys are like talking to 1000 of your aunts and uncles and paying attention to what works for them.
For a condition as varied as migraines, there is not enough research on the usage patterns and benefits of cannabis, especially because as Dr. Reynolds said, for migraines, “very many victims of this malady have for years kept their sufferings in abeyance by taking hemp at the moment of threatening, or onset of the attack.” Other doctors of the time concurred.
In this survey of 1300+ patients from a tertiary headache center (a tertiary care center is specialized for patients who can’t be helped by the hospital or secondary specialists), the researchers asked about the last three years of cannabis-based product usage. The most frequently cited reason for using cannabinoids were for treating headaches and for sleep. The most popular cannabinoid profile was a mix of THC and CBD with the most common delivery methods being either inhaled or edibles. And the list of symptomatic relief is impressive:
· 78% experienced reductions in migration intensity, 73% had reduced duration, and 62% had reduced frequency
· More than half saw declines in nausea
· 81% had less sleep disturbances
· 71% experienced less anxiety
· 57% reported less depression
· 49% used less of other medications and 14% completely eliminated other medications
For usage, 58% said they only used cannabinoids when experiencing a headache while 42% took them as a daily prophylactic for prevention. Of the 20% who reported side effects, the most common was fatigue.
Check out the Pain & Inflammation page at CVResearch.info for more research on headaches and migraines.
Best Of Cannabinoid Science...
Another negative secret buyers analysis of CBD: out of 202 CBD products, 74% deviated from their label claim of potency by at least 10%, over 20% contained heavy metals (especially lead), almost 90% contained solvents (especially hexane) & the majority contained pesticides
Product labeling accuracy and contamination analysis of commercially available cannabidiol product samples
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1335441/full
Dear Lord. Please buy from PlusCBD. See the certificate of analysis for every batch & rest easy that you’re not getting any of that shite.
Clinical
In people with tuberous sclerosis complex (the growth of many non-cancerous tumors that often lead to seizures), a healthcare cost analysis found a benefit in adding CBD to the usual standard of care treatment
A Cost-Utility Analysis of Add-On Cannabidiol Versus Usual Care Alone for the Treatment of Seizures Associated with Tuberous Sclerosis Complex in England and Wales
https://pubmed.ncbi.nlm.nih.gov/38441854/
In a survey of 267 CBD users, the top five reasons for using CBD were stress, sleep problems, improvement in well-being, improved mood & anxiety relief
Cannabidiol usage, efficacy, and side effects: analyzing the impact of health conditions, medications, and cannabis use in a cross-sectional online pilot study
https://pubmed.ncbi.nlm.nih.gov/38487574/
“Overall, nearly 70% of the individuals found CBD products to be effective. Sublingual administration was more popular among non-cannabis users, while cannabis users preferred smoking and vaping to CBD administration.”
A case report of using CBG for the anxiety of the COVID pandemic
Minor Cannabinoids for the Treatment of Anxiety During the COVID-19 Pandemic: A Case Report
https://www.endocannabinoidmedicine.com/academicarticle/minor-cannabinoids-for-the-treatment-of-anxiety-during-the-covid-19-pandemica-case-report/
A big review of recent clinical THC trials
Δ9-Tetrahydrocannabinol (THC): A Critical Overview of Recent Clinical Trials and Suggested Guidelines for Future Research
https://www.mdpi.com/2077-0383/13/6/1540
Exercise
A review of how exercise works with the endocannabinoids & our dopamine reward system (nice ECS & exercise charts)
Aerobic Exercise and Endocannabinoids: A Narrative Review of Stress Regulation and Brain Reward Systems
https://pubmed.ncbi.nlm.nih.gov/38440201/
For exercise, cannabis users seem more sensitive to the positive effects
Prior acute exercise restores postprandial fat oxidation in active cannabis users
https://physoc.onlinelibrary.wiley.com/doi/pdf/10.14814/phy2.15968
On taking ultrasound scans of heart changes after combining CBD before exercise
The Influence of Cannabidiol on Flow- Mediated Dilation in Exercising Populations: A Narrative Review
https://www.researchgate.net/publication/378709138_The_Influence_of_Cannabidiol_on_Flow-_Mediated_Dilation_in_Exercising_Populations_A_Narrative_Review
Harms
For cannabinoid hyperemesis syndrome, new guidelines for the identification & treatment
AGA Clinical Practice Update on Diagnosis and Management of Cannabinoid Hyperemesis Syndrome: Commentary
https://pubmed.ncbi.nlm.nih.gov/38456869/
In a meta-analysis of 36 studies on the prenatal effects of cannabis, the offspring exposed to cannabis had a greater risk of structural birth defects including of the heart, guts, central nervous system, genitourinary system & other unclassified birth defects
The association between prenatal cannabis use and congenital birth defects in offspring: A cumulative meta-analysis
https://www.sciencedirect.com/science/article/pii/S0892036224000229
On youth & mental health, this review of 24 articles found “that cannabis use is associated with depression, psychosis, suicide, cannabis use disorder, dependence, decline in cognitive function, and the development of externalising behaviour, particularly attention deficit hyperactivity disorder”
Cannabis Use and Its Impact on Mental Health in Youth in Australia and the United States: A Scoping Review
https://pubmed.ncbi.nlm.nih.gov/38534804/
A meta-analysis of 3,600+ medical cannabis users found ~25% to have cannabis use disorder
The prevalence of cannabis use disorders in people who use medicinal cannabis: A systematic review and meta-analysis
https://www.sciencedirect.com/science/article/pii/S0376871624001844
A review of 32 studies found positive associations between more cannabis retail locations & increased calls to poison control centers due to cannabis, increased cannabis use & cannabis related hospitalizations in pregnancy & more frequent cannabis use in adults & young adults - but not increase cannabis use in adolescence, health care service use related to cannabis or increased adverse birth outcomes
The association between physical availability of cannabis retail outlets and frequent cannabis use and related health harms: a systematic review
https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(24)00035-8/fulltext
A case report of delta-8 THC gradually leading to psychosis
Clinical Diagnosis and Management of Gradual Onset Cannabis-Induced Psychosis Following the Consumption of Delta-8-Tetrahydrocannabinol
https://assets.cureus.com/uploads/case_report/pdf/219925/20240304-32487-1i00k3g.pdf
A case report of spontaneous pneumothorax (air in the chest cavity) in a heavy tobacco & cannabis user
Recurrent Spontaneous Pneumothorax Secondary to Marijuana and Tobacco Abuse
https://pubmed.ncbi.nlm.nih.gov/38361711/” Tobacco association with a higher incidence of spontaneous pneumothorax has been well documented, but marijuana and spontaneous pneumothorax connection has not been well studied. However, it has been observed that patients who use marijuana and tobacco simultaneously have a higher incidence of spontaneous tension and larger pneumothoraces, as well as longer postoperative stay and higher recurrence than cigarette-only users.”
In the California Pet Poison Helpline, cannabis & amphetamine rank in the top 20 toxicants most frequently consulted about
Dog and cat exposures to drugs of abuse identified by the California animal health and food safety laboratory system 2013-2023
https://pubmed.ncbi.nlm.nih.gov/38515534/
Reviews
For Alzheimer's disease, a positive review of 37 studies on the use of cannabinoids
DELVE INTO THE SYNTHESIS AND CHEMISTRY OF PHYTOCANNABINOIDS, EMPHASIZING THEIR POTENTIAL AS THERAPEUTIC ALTERNATIVES FOR NEUROPSYCHOLOGICAL DISORDERS, INCLUDING ALZHEIMER
https://www.jptcp.com/index.php/jptcp/article/view/4691
And a molecular assessment of why cannabinoids make sense for treating Alzheimer's
Exploring Cannabis sativa L for Anti-Alzheimer Potential: An extensive Computational Study including Molecular Docking, Molecular Dynamics, and ADMET Assessments
https://assets.researchsquare.com/files/rs-3986384/v1/cc9293ff-1bec-45fa-9c91-27705c0ac534.pdf?c=1709473147
A long review of PEA for chronic neuropathic pain (great charts!)
A Decades-Long Journey of Palmitoylethanolamide (PEA), as a Cornerstone in Chronic Neuropathic Pain Management: A Comprehensive Narrative Review
https://www.preprints.org/manuscript/202403.0174/v1
A review on using cannabis oil for cancer related pain
Cannabinoids for Cancer-related Pain Management: An Update on Therapeutic Applications and Future Perspectives
https://pubmed.ncbi.nlm.nih.gov/38423660/
And a review of cannabis for pain management
Cannabis in pain management
https://www.researchgate.net/publication/378588848_Cannabis_in_pain_management
A review of sleep, the endocannabinoid system & the glial cells (guardian immune cells of the brain)
Sleep, Glial Function, and the Endocannabinoid System: Implications for Neuroinflammation and Sleep Disorders
https://www.mdpi.com/1422-0067/25/6/3160
For lactation, a review of the little that's known about maternal cannabis use & the effects on milk composition & production
Maternal Cannabis Use during Lactation and Potential Effects on Human Milk Composition and Production: A Narrative Review
https://pubmed.ncbi.nlm.nih.gov/38432590/
In heart attacks, a review of targeting the CB2 receptor for lowering inflammation, enhancing tissue repair & lowering cell death (nice charts of the many pathways involved)
CB2 Cannabinoid Receptor as a Potential Target in Myocardial Infarction: Exploration of Molecular Pathogenesis and Therapeutic Strategies
https://pubmed.ncbi.nlm.nih.gov/38338960/
For biochem nerds, a review of the cannabinoids & the Toll-like receptors (innate immune system proteins)
Toll-like receptor signalling as a cannabinoid target
https://pubmed.ncbi.nlm.nih.gov/38438052/
And how the cannabinoids bind to the inhibitory Cys-loop receptors of glycine & GABA (two key neurotransmitters)
Structural Basis for Molecular Recognition of Cannabinoids by Inhibitory Cys-Loop Channels
https://pubmed.ncbi.nlm.nih.gov/38428383/
Preclinical
Proof in mice that endocannabinoids cause retrograde signaling (an important negative feedback loop where endocannabinoids go backwards towards the upstream neuron & tells it to calm down its firing)
Retrograde endocannabinoid signaling at inhibitory synapses in vivo
https://pubmed.ncbi.nlm.nih.gov/38422134/
In rats with neuroinflammation, CBD improved their memory & decreased inflammatory cytokines
Cannabidiol improves memory and decreases IL-1β serum levels in rats with lipopolysaccharide-induced inflammation
https://pubmed.ncbi.nlm.nih.gov/38351784/
In a rat model of traumatic brain injury, CBD caused neuroprotection & restored their synaptic remodeling via TNF-α in the astrocytes (a prominent brain immune cell)
Purinergic Astrocyte Signaling Driven by TNF-α After Cannabidiol Administration Restores Normal Synaptic Remodeling Following Traumatic Brain Injury
https://www.sciencedirect.com/science/article/abs/pii/S0306452224000988
In a tissue & rat model of an inflamed prostate & chronic pelvic pain syndrome, CBD lowered pain & inflammation via CB2 & TRPV1 receptors as well as the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) pathway
Cannabidiol Alleviates Chronic Prostatitis and Chronic Pelvic Pain Syndrome via CB2 Receptor Activation and TRPV1 Desensitization
https://www.wjmh.org/DOIx.php?id=10.5534/wjmh.230352
In a mouse model of epilepsy, CBD caused anticonvulsant effects alone but when combined with low levels of THC, they worked better than either cannabinoids alone, probably via a serotonin receptor
Cannabidiol Exerts Anticonvulsant Effects Alone and in Combination with Δ9-THC through the 5-HT1A Receptor in the Neocortex of Mice
https://www.mdpi.com/2073-4409/13/6/466
In a mouse model of the toxicity from high doses of nicotine, CBD reduced anxiety behaviors via liver enzymes, protection of tissues, balancing of redox reactions & mitigating changes to the levels of BDNF (an important brain growth factor)
Cannabidiol Modulation of Nicotine-Induced Toxicity: Assessing Effects on Behavior, Brain-Derived Neu-Rotrophic Factor, and Oxidative Stress C57BL/6 Mice
https://europepmc.org/article/ppr/ppr816039
In goldfish exposed to an insecticide, CBD protected the brain from oxidative stress
Antioxidant effects of the phytocannabinoid cannabidiol (CBD) in the brain of chlorpyrifos-exposed goldfish (Carassius auratus)
https://oarjpublication.com/journals/oarjls/sites/default/files/OARJLS-2023-0044.pdf
A bio assay finds a new compound in cannabis: methoxy canniprene (methoxy isoprenyl bibenzyl
Bioassay-guided fractionations of Cannabis sativa extract and HPLC-assisted purifications of anti-proliferative active fractions lead to the isolation of 16 known and one new phytomolecule and their in-silico analysis
https://link.springer.com/article/10.1007/s00044-024-03199-y
For the intestinal health of piglets, the probiotic Lactobacillus johnsonii improved intestinal barrier function & reduced post weaning diarrhea via the endocannabinoid system (colonic diacylglycerol lipase beta levels)
Lactobacillus johnsonii Improves Intestinal Barrier Function and Reduces Post-Weaning Diarrhea in Piglets: Involvement of the Endocannabinoid System
https://pubmed.ncbi.nlm.nih.gov/38338136/
And in rats, the ability of thymoquinone (the primary active ingredient of Nigella sativa black seeds) seemed to lower pain via the cannabinoid & adenosine receptors
Effect of thymoquinone on acetic acid-induced visceral nociception in rats: role of central cannabinoid and α2-adrenergic receptors
https://vrf.iranjournals.ir/article_710018_84b84a4e4c092fd22eb663c7b0d68a67.pdf
Another two for the list of natural remedies working via the endocannabinoid system…
An evergreen note on reading restricted papers:
First stop for seeing if there’s a free version of a paper, use the Google Scholar Chrome extension (Mac version), Google Scholar itself or try ResearchGate.
Three other helpful browser extensions are: Unpaywall, Open Access Button & PaperPanda
For the infamous backdoor, use Sci-Hub – the pirated papers repository (Chrome extension here). This works better for older paper than the stuff that just came out.
Finally, email the author. They’re almost always happy to oblige because, thanks to the predatory academic publishing system, they don’t make a dollar off of their papers.
the Headlines & Fav Articles
The USDA approves a hemp cultivar that produces CBG but no CBD or THC
https://www.marijuanamoment.net/usda-approves-genetically-modified-hemp-that-produces-no-thc-or-cbd
In California, a study of how cannabis growing is forced towards more marginalized farmland
A theory of geo-social marginalization: A case study of the licensed cannabis industry in California
https://pubmed.ncbi.nlm.nih.gov/38430877/
An even-handed analysis of what happened in the NY canna-world
https://www.newyorker.com/magazine/2024/02/26/legal-weed-in-new-york-was-going-to-be-just-and-fair-what-happened
Glad to see that Jackie Bryant of CannaBitch won her fight against Strike
https://hightimes.com/business/stripe-says-no-to-funding-cannabis-journalism-backs-down-after-a-fight
Sketch of the week: SNL’s ‘We Got Too High’ (hattip to sister Tessa Pelger)
International
Germany officially legal: 3 plants, 25 g possession & social clubs to begin
https://www.marijuanamoment.net/germanys-marijuana-legalization-bill-is-officially-signed-into-law-and-will-take-effect-on-monday
For the first time ever, the UN Commission on Narcotic Drugs recognizes harm reduction
https://twitter.com/IDPCnet/status/1771302671061856485
https://undocs.org/Home/Mobile?FinalSymbol=E%2FCN.7%2F2024%2FL.5
Switzerland released results of its pilot program of adult use sales in Basel-Stadt: the main problem is dissatisfaction with only having flower & hash but no edibles, oils or e-liquids + weak products
https://www.bs.ch/nm/2024-erste-zwischenergebnisse-der-cannabisstudie-weed-care-gd.html
“Some of the participants also wanted stronger products with more than the permitted 20 percent THC. This explains why 49 percent of the participants consumed cannabis from illegal sources in addition to the study cannabis… Regine Steinauer, Head of the Addiction Department, on the interim results: “The interim results do not yet allow any conclusive findings. However, it seems to be becoming clear that the product range must be geared more towards the needs of consumers in order to have an impact on the black market in the future.”
Ireland approved only 53 medical cannabis patients in recent years
https://internationalcbc.com/ireland-has-only-approved-53-patients-for-medical-cannabis-in-recent-years
In the UK, the court sided with a medical cannabis patient who refused to give saliva or blood to the police
https://cannabishealthnews.co.uk/2024/03/27/cannabis-patient-wins-small-victory-after-battling-driving-charges
Belgium PM says no legalization under his watch
https://www.politico.eu/article/belgium-will-not-legalize-drugs-says-prime-minister
In Brazil, interviews of psychiatrists & judges across the Polígono da Maconha [Marijuana Polygon] region
Therapeutic justice: Meanings attributed by psychiatrists and judges to the law regarding marijuana
https://www.scielo.br/j/dilemas/a/xPGL7J8DtsqWrfFPxxBdXCs/abstract/?lang=en
On how the Mexican judiciary came to their decision to end the absolute prohibition of adult use cannabis (Spanish)
Precedente judicial y consumo lúdico de marihuana en México
https://www.scielo.org.mx/pdf/rms/v86n1/2594-0651-rms-86-01-167.pdf
The Laws, The War on Drugs & the End of Prohibition
Surprisingly, in a study of the effects of legalization in New Mexico, less pregnant people used cannabinoids after legalization than before
The impact of recreational cannabinoid legalization on utilization in a pregnant population
https://pubmed.ncbi.nlm.nih.gov/38444440/
A legal argument that all the uses of cannabis do not violate the international Single Conventions of 1961 & 1971 on narcotic controls
Hemp and the Treaty: deciphering the legal status of industrial Cannabis and cannabidiol under the drug control conventions
https://www.unodc.org/documents/commissions/CND/CND_Sessions/CND_67/Stakeholder_Contributions/HumanRights/ENCOD4_-_HR.pdf
Driving
A comparison of the top 4 tests for THC levels in the saliva
Reliability of roadside oral fluid testing devices for ∆9 -tetrahydrocannabinol (∆9 -THC) detection
https://pubmed.ncbi.nlm.nih.gov/38440942/
"The Dräger DrugTest® outperformed the other devices with a 96.8% sensitivity, 97.1% specificity, and 97.0% efficiency at a 5-ng/mL LC-MS/MS confirmation cutoff. The WipeAlyser Reader® had good performance with a 91.4% sensitivity, 97.2% specificity, and 96.4% efficiency. AquilaScan® and Druglizer® had unacceptable performance for cannabinoid detection, highlighted by sensitivity <13%."
Or course, the elephant in the room is the lack of correlation between the THC in your saliva & your intoxication levels.
For detection of impairment, eyelid tremors not a reliable enough method
Accuracy and replicability of identifying eyelid tremor as an indicator of recent cannabis smoking
https://pubmed.ncbi.nlm.nih.gov/38421358/
Psychedelics, Plant Medicines & Other Psychoactives
Charges of poor science & messiah-ism against the recently deceased Dr. Roland Griffiths of John Hopkins psychedelic fame
https://www.nytimes.com/2024/03/21/health/psychedelics-roland-griffiths-johns-hopkins.html
But I read this & mostly thought, meh.
On psychedelic therapy & not fucking your patients
Two cases of extended difficulties after Braxia's psilocybin TRD trial
The Psychoactive Research
An analysis finds that the adolescent use of psychedelics is linked to lower rates of psychotic symptoms
Adolescent Psychedelic Use and Psychotic or Manic Symptoms
https://pubmed.ncbi.nlm.nih.gov/38477889/
On how ibogaine moves through people with opioid use disorder
The pharmacokinetics and pharmacodynamics of ibogaine in opioid use disorder patients
https://pubmed.ncbi.nlm.nih.gov/38519421/
For depression & anxiety, the efficacy of sublingual ketamine
Sublingual Ketamine for Depression and Anxiety: A Retrospective Study of Real-World Clinical Outcomes
https://www.medrxiv.org/content/10.1101/2024.01.30.24301798v1
And low doses of IV ketamine for treatment-resistant depression
IV low dose ketamine infusions for treatment resistant depression: Results from a five-year study at a free public clinic in an academic hospital
https://pubmed.ncbi.nlm.nih.gov/38518518/
And high doses of oral esketamine for treatment-resistant depression
Oral esketamine in patients with treatment-resistant depression: a double-blind, randomized, placebo-controlled trial with open-label extension
https://pubmed.ncbi.nlm.nih.gov/38523183/
For depression, on the psychological mechanisms of psilocybin versus escitalopram
Unique Psychological Mechanisms Underlying Psilocybin Therapy Versus Escitalopram Treatment in the Treatment of Major Depressive Disorder
https://link.springer.com/article/10.1007/s11469-024-01253-9
On the importance of the therapeutic alliance in using psilocybin for depression
The therapeutic alliance between study participants and intervention facilitators is associated with acute effects and clinical outcomes in a psilocybin-assisted therapy trial for major depressive disorder
https://pubmed.ncbi.nlm.nih.gov/38483940/
On how your attachment history predicts your psychedelic experience
Perceived attachment history predicts psychedelic experiences: A naturalistic study
https://akjournals.com/view/journals/2054/aop/article-10.1556-2054.2024.00330/article-10.1556-2054.2024.00330.xml
On how MDMA & methamphetamine change conflict processing
Conflict monitoring and emotional processing in 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine users - A comparative neurophysiological study
https://pubmed.ncbi.nlm.nih.gov/38447413/
On how DMT changes the brain substates & the relation to the meaningfulness of the experience
Brain substates induced by DMT relate to sympathetic output and meaningfulness of the experience
https://pubmed.ncbi.nlm.nih.gov/38464275/
On the safety of psilocybin in healthy participants
Safety pharmacology of acute psilocybin administration in healthy participants
https://www.sciencedirect.com/science/article/pii/S277240852400125X
On using mixed methods to study psilocybin microdosing
Salience, Sensemaking, and Setting in Psilocybin Microdosing: Methodological Lessons and Preliminary Findings of a Mixed Method Qualitative Study
https://osf.io/preprints/osf/523n4
5-MeO-DMT’s structure-activity relationships
Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties
https://pubmed.ncbi.nlm.nih.gov/38486047/
The Plant & the History
Growing, Farming & Processing
A Wisconsin study on the best rate of compost application
A compost application rate for sustainable hemp agriculture in Wisconsin
https://minds.wisconsin.edu/bitstream/handle/1793/85039/P24.03%20Desai%20-%20Research%20in%20the%20Rotunda.pdf?sequence=1
The water content of different cannabis varieties with ranges from 3.8% to 8.5%
Water content determination in different varieties of Cannabis flowers
https://bulletin.mfd.org.mk/volumes/Volume%2069_1/69_1_008.pdf
The microbial diversity of hemp cultivars
Microbiome Diversity and Variations in Industrial Hemp Genotypes
https://assets.researchsquare.com/files/rs-3946962/v1/5a74cc87-d654-401d-842c-44103be27dcb.pdf?c=1709897790
A thesis project on the different microbiomes of diploid & triploid hemp plants (2 or 3 copies of their chromosomes – a common agricultural technique for boosting yield)
Study on Interactions between Endophytes and Hemp for Healthy Plants and Quality Products
https://harvest.usask.ca/server/api/core/bitstreams/5a783685-0dbf-48fb-b0f9-b92c914293e6/content
An analysis of the economics of hemp production & processing
Techno-Economic Analysis of Hemp Production, Logistics and Processing in the U.S
https://www.mdpi.com/2673-8783/4/1/8
An affordable method for batch supercritical extraction
Affordable method for batch supercritical extraction using solid carbon dioxide–Extraction of cannabis threshing residues
https://www.sciencedirect.com/science/article/abs/pii/S0255270124000606
A green extraction method for producing hemp seeds cake
Green extraction of hemp seeds cake (Cannabis sativa L.) with 2-methyloxolane: A response surface optimisation study
https://www.sciencedirect.com/science/article/pii/S2352554124000846
An analysis of the carbon footprint of hemp in southern Italy
Carbon footprint of hemp and sunflower oil in southern Italy: A case study
https://www.sciencedirect.com/science/article/pii/S1470160X24002437
A dataset of eight Thai cannabis varieties
A comprehensive dataset of eight Thai cannabis classes for botanical exploration
https://www.sciencedirect.com/science/article/pii/S2352340924002610
An analysis of three Moroccan cannabis cultivars
A Comparative Study of the Biometric, Germinative, and Physicochemical Characteristics of Fruits and Oils of Three Cannabis Strains (Cannabis sativa L.var indica) Cultivated in the Rif Region of Morocco
https://www.phcogj.com/sites/default/files/PharmacognJ-16-1-156.pdf
An analysis of the composition of cannabis extracts
COMPARATIVE STUDY OF POLYPHENOLIC COMPOSITION AND REDUCING PROPERTIES OF EXTRACTS OF CANNABIS SATIVA L., CANNABIS INDICA AND CANNABIS HYBRID
https://j.uctm.edu/index.php/JCTM/article/view/263
Hemp as Food
An analysis in Virginia of three hemp cultivars found them to be a potential forage crop for feeding livestock
Hemp as a forage crop: Harvest date effects on yield and nutritive value
https://academic.oup.com/jas/article/102/Supplement_1/45/7617931
An analysis of hemp as a feed for beef cattle
An in-vitro analysis of hemp as feed for beef cattle
https://academic.oup.com/jas/article/102/Supplement_1/24/7617922
And a digestibility study of hemp for cattle
In-situ degradability of hemp (Cannabis sativa L.) plant components in cattle
https://academic.oup.com/jas/article/102/Supplement_1/96/7618004
Characterization of the bioactive molecules in cannabis seeds
Chemical and functional characterization of the main bioactive molecules contained in hulled Cannabis sativa L. seeds for use as functional ingredients
https://www.sciencedirect.com/science/article/pii/S2666154324001212
Industrial Use
On using hemp canvas for greenhouse growing & mulching
Effect of plastic film and hemp canvas mulching on soil properties, microbial diversity and lettuce yield
https://link.springer.com/article/10.1007/s11104-024-06589-8
On producing biodiesel from hempseed oil
Biodiesel production from hempseed (Cannabis sativa L.) oil: Providing optimum conditions by response surface methodology
https://www.stet-review.org/articles/stet/pdf/2024/01/stet20230166.pdf
On using waste from cannabis & grapevines for producing bimetallic nanoparticles
Bimetallic nanoparticle production using Cannabis sativa and Vitis vinifera waste extracts
https://pubmed.ncbi.nlm.nih.gov/38343999/
On making composites of hemp & gypsum for building construction
Development and Characterization of Innovative Hemp–Gypsum Composites for Application in the Building Industry
https://www.mdpi.com/2076-3417/14/6/2229
For hemp yarn, an assessment of their carbon footprint & oxygen footprint
Carbon footprint and oxygen footprint assessment of hemp yarn
https://www.inderscienceonline.com/doi/abs/10.1504/IJGW.2024.137161
CANNABINOID SCIENCE
On the effects of various Ayuruvedic cannabis processing methods
Pharmacognostical specification of Cannabis sativa L. (Bhanga) leaves processed with various Ayurveda-recommended methods
https://journals.lww.com/jdra/fulltext/2024/09010/pharmacognostical_specification_of_cannabis_sativa.4.aspx?context=latestarticles
“It has been processed by four different methods, namely Jalanimajjana (water dipping), Jalaprakshalana (water-wash), Godugdha Swedana (boiling in cow’s milk), and Babbul-twak Kwatha Swedana (boiling in the decoction of Acacia arabica (Lam.) Willd.”
In mice, a comparison of the neurochemical effects from different delivery systems & cannabinoid mixtures
Oral Cannabis consumption and intraperitoneal THC:CBD dosing results in changes in brain and plasma neurochemicals and endocannabinoids in mice
https://pubmed.ncbi.nlm.nih.gov/38429800/
Public Health
Unsurprisingly, people who live in a home with a complete ban on cannabis smoking are more likely to consider cannabis second-hand smoke to be a health risk
Perception of harm is strongly associated with complete ban on in-home cannabis smoking: a cross-sectional study
https://pubmed.ncbi.nlm.nih.gov/38429696/
On integrating cannabis education into the athletic training curriculum
Integrating Cannabis Education into the Athletic Training Curriculum
https://scholarworks.bgsu.edu/cgi/viewcontent.cgi?article=1337&context=jsmahs
A survey of physician assistants found that only half felt comfortable discussing medical cannabis & even less for discussing drug interactions
A Pilot Study of Physician Assistant Student and Alumni Attitudes, Awareness, and Perceptions of Medical and Recreational Marijuana
https://www.ingentaconnect.com/content/psp/hbpr/2024/00000011/00000001/art00003;jsessionid=42ep6on0e34bs.x-ic-live-03?crawler=true&mimetype=application/pdf
In Canada, interviews of health care practitioners found significant knowledge gaps around cannabis
Planting the seeds for success: A qualitative study exploring primary healthcare providers’ perceptions about medical cannabis
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0295858
Adolescents & Young Adults
Brain scans of young adults found little differences in the dorsolateral prefrontal cortex between heavy cannabis users & controls
Computational simulation of transcranial magnetic stimulation-induced electric fields in the dorsolateral prefrontal cortex of heavy cannabis using individuals
https://pubmed.ncbi.nlm.nih.gov/38359540/
The Brain & Neurological Disorders
In patients with Parkinson's disease, the effects of dopamine medication on endocannabinoid pathway alterations
The role of dopaminergic medication, lipid, and endocannabinoid pathway alterations in idiopathic and PRKN/PINK1-mediated Parkinson’s disease – a large-scale targeted metabolomics study
https://www.medrxiv.org/content/10.1101/2024.03.01.24303613v1
In a meta-analysis of treatments for Dravet syndrome (a severe childhood epilepsy), the drugs stiripentol & fenfluramine were more effective than CBD in reducing seizures but all had a similar rate of serious side effects
Comparative efficacy and safety of stiripentol, cannabidiol and fenfluramine as first-line add-on therapies for seizures in Dravet syndrome: A network meta-analysis
https://pubmed.ncbi.nlm.nih.gov/38427284/
In a mouse model of an early life concussion, the endocannabinoid system helped to rescue neuronal activity & plasticity as well as normalizing sensory related behavior
Endocannabinoid-mediated rescue of somatosensory cortex activity, plasticity and related behaviors following an early in life concussion
https://pubmed.ncbi.nlm.nih.gov/38352553/
On using a MAGL inhibitor (which raises 2-AG levels) that can be traced by PET scans & perhaps be used for treating neurodegenerative diseases
Preclinical Evaluation of the Reversible Monoacylglycerol Lipase PET Tracer (R)-[11 C]YH132: Application in Drug Development and Neurodegenerative Diseases
https://pubmed.ncbi.nlm.nih.gov/38441502/
Mental Health & Substance Use Disorders
An editorial on the data about cannabis for PTSD
What Does a Systematic Review of Cannabis and PTSD Tell Us? That We Need to Learn More
https://pubmed.ncbi.nlm.nih.gov/38353646/
In both veterans & the general population, those with psychiatric disorders saw a greater increase in cannabis use & cannabis use disorder diagnoses
Cannabis Use and Cannabis Use Disorder among U.S. Adults with Psychiatric Disorders: 2001-2002 and 2012-2013
https://www.medrxiv.org/content/10.1101/2024.02.29.24303158v1.full.pdf
In humans watching trauma films, their stress levels were correlated to the endocannabinoid levels in their saliva, with the effects moderated by anandamide
Trauma film viewing and intrusive memories: Relationship between salivary alpha amylase, endocannabinoids, and cortisol
https://www.sciencedirect.com/science/article/pii/S0306453024000519
In a rat model of PTSD, their neuroplasticity & endocannabinoid gene expression predicted their susceptibility to fear
Endocannabinoid and neuroplasticity-related changes as susceptibility factors in a rat model of posttraumatic stress disorder
https://www.biorxiv.org/content/10.1101/2024.03.06.583339v2.full.pdf
In a mouse model of childhood maltreatment, 2AG emerged as a key regulator of fear generalization
PREFRONTAL CORRELATES OF FEAR GENERALIZATION DURING ENDOCANNABINOID DEPLETION
https://pubmed.ncbi.nlm.nih.gov/38352388/
In mice feeling anxious from their THC treatment, the adenosine receptors seemed to be involved
Involvement of Adenozine A2a Receptors in Anxiety-like Behaviors in Tetrahydrocannabinol Treated Mice
https://assets.researchsquare.com/files/rs-3991109/v1/c57f6515-75a6-44a3-97a0-fdc65818e739.pdf?c=1709554962
In a mouse model of neurodegeneration, inhibiting the FAAH enzyme (which raises the level of anandamide, a function of CBD) improved sleep
Evaluating Fatty Acid Amide Hydrolase as a Suitable Target for Sleep Promotion in a Transgenic TauP301S Mouse Model of Neurodegeneration
https://pubmed.ncbi.nlm.nih.gov/38543105/
A new model of cannabis addiction hidden behind a paywall
A new neural diathesis-stress model of cannabis addiction based on the diurnal cortisol pattern and childhood maltreatment in users
https://pubmed.ncbi.nlm.nih.gov/38350326/
Pain & Surgeries
An analysis of the painkilling effects of Moroccan cannabis oil
Chemical Analysis, Antioxidant, Toxicology, and Antinociceptive Effects of Moroccan Cannabis sativa Essential Oil
https://www.researchgate.net/publication/378654614_Chemical_Analysis_Antioxidant_Toxicology_and_Antinociceptive_Effects_of_Moroccan_Cannabis_sativa_Essential_Oil
In spinal cord slices, anandamide lowered spinal pain transmission under both control & inflammatory conditions
Dual effect of anandamide on spinal nociceptive transmission in control and inflammatory conditions
https://www.sciencedirect.com/science/article/pii/S0753332224002531
Hormones & Reproduction
In women of reproductive age with disabilities, they were significantly more likely to see no risk from weekly cannabis use
Perception of Risk of Harm from Cannabis Use Among Women of Reproductive Age with Disabilities
https://pubmed.ncbi.nlm.nih.gov/38442223/
In rat offspring exposed to vaporized cannabis prenatally, they had an altered balance of excitatory & inhibitory inputs of neurons projecting it to the prefrontal cortex from the nucleus accumbens (a neural interface between motivation & action)
Maternal cannabis use alters excitatory inputs to corticostriatal efferent neurons in rat offspring
https://www.biorxiv.org/content/10.1101/2024.03.03.583210v1.full.pdf
In a tissue model of male fertility, the endocannabinoid 2AG seemed helpful at low levels but harmful at high levels (hormesis)
Hormetic effects of a cannabinoid system component, 2-arachidonoyl glycerol, on cell viability and expression profile of growth factors in cultured mouse Sertoli cells: Friend or foe of male fertility?
https://www.sciencedirect.com/science/article/abs/pii/S089062382400042X
The Immune System & Antimicrobial
The antimicrobial activity of two cannabis extracts
Chemical Characterization and Evaluation of the Antimicrobial Activity of Extracts from Two Cultivars of Cannabis sativa L. (Tisza and Kompolti) Grown in Sardinia
https://www.preprints.org/manuscript/202403.0053/v1
The Guts, Metabolism, Oral Health & CHS
In human intestine samples, those with type-2 diabetes had higher levels of endocannabinoid mediators
Investigating the alterations of endocannabinoidome signaling in the human small intestine in the context of obesity and type 2 diabetes
https://pubmed.ncbi.nlm.nih.gov/38515705/
In rodents, cannabis activated hunger neurons
Cannabis activates hunger neurons in rodents
https://pubmed.ncbi.nlm.nih.gov/38438744/
In the small intestines of Holstein bulls, an analysis of the levels of the CB1, CB2 & TRPV1 receptors
Gene expression level and immunohistochemical localization of cannabinoid and cannabinoid-related receptors in the small intestine of Holstein bulls (Bos taurus taurus)
https://intapi.sciendo.com/pdf/10.2478/aoas-2024-0016
In adolescent mice, daily THC administration produced an adult metabolic phenotype of reduced fat mass, partial resistance to obesity & dyslipidemia as well as impaired thermogenesis & lipolysis (process of breaking down fat into glycerol & fatty acids for energy)
Overactivation of the Endocannabinoid System in Adolescence Disrupts Adult Adipose Organ Function in Mice
https://pubmed.ncbi.nlm.nih.gov/38474425/
In a rat model of type 2 diabetes, the terpene beta-caryophyllene lowered oxidative stress as well as dysfunction of the liver cell’s mitochondria (powerhouse of the cell)
β-caryophyllene attenuates oxidative stress and hepatocellular mitochondrial dysfunction in type-2 diabetic rats induced with high fat and fructose diets
https://pubmed.ncbi.nlm.nih.gov/38455602/
The Lungs
A doctor on fears about the liberalization of cannabis laws negatively affecting respiratory health
Respiratory health effects of cannabis-How should we respond to liberalization of cannabis laws?
https://pubmed.ncbi.nlm.nih.gov/38346930/
In a rat model of high blood pressure in the lungs, the terpene beta-caryophyllene lowered hypertension & reduced oxidative stress
Effect of free and nanoemulsified β-caryophyllene on monocrotaline-induced pulmonary arterial hypertension
https://www.sciencedirect.com/science/article/abs/pii/S0167488924000478
The Liver
In a mouse model of non-alcoholic fatty liver disease, docosahexaenoic acid (DHA) improved the disease state via suppression of the endocannabinoid system
Docosahexaenoic Acid Modulates Nonalcoholic Fatty Liver Disease by Suppressing Endocannabinoid System
https://pubmed.ncbi.nlm.nih.gov/38430210/
The Skin
In people with seborrheic dermatitis (a common skin condition of scaly patches, inflammation & stubborn dandruff), topical hemp seed extract for two weeks reduced the clinical severity & the production of sebum (skin oil)
The Efficacy of Hemp Seed Extract Cream in Treating Facial Seborrheic Dermatitis; A Pilot Study
https://rsucon.rsu.ac.th/files/proceedings/RSUSCI2023/IN23-046.pdf
Cancer & Chemotherapy
In a survey of cancer patients & survivors, most did not know the concentrations of CBD & THC in their products
Self-reported knowledge of tetrahydrocannabinol and cannabidiol concentration in cannabis products among cancer patients and survivors
https://pubmed.ncbi.nlm.nih.gov/38443674/
A review of cannabinoids to treat glioblastoma (the most aggressive brain cancer)
Cannabinoids in the treatment of glioblastoma
https://link.springer.com/article/10.1007/s43440-024-00580-x
In ovarian cancer cells, CBD, CBG & CBDA significantly reduced their viability
Investigating Cannabis sativa bioactive compounds as an anti-cancer treatment in high-grade serous ovarian cancer
https://aacrjournals.org/cancerres/article/84/5_Supplement_2/B019/734497
In breast cancer, the anti-tumor effects of CBD (Portuguese)
The antineoplastic effects of cannabidiol in breast cancer
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/67690
On the synergy between CBD & platinum drugs for anti-tumor effects
Platinum (IV) drugs with cannabidiol inducing mitochondrial dysfunction and synergistically enhancing anti-tumor effects
https://pubmed.ncbi.nlm.nih.gov/38490045/
In melanoma cells, a study of the mechanisms cannabis extracts used to cause cell death
Evaluating the Mechanism of Cell Death in Melanoma Induced by the Cannabis Extract PHEC-66
https://pubmed.ncbi.nlm.nih.gov/38334660/
In cancer cells, how functional selectivity of the CB1 receptor altered transition to the metastatic phenotype
Functional Selectivity of Cannabinoid Type 1 G Protein-Coupled Receptor Agonists in Transactivating Glycosylated Receptors on Cancer Cells to Induce Epithelial–Mesenchymal Transition Metastatic Phenotype
https://www.mdpi.com/2073-4409/13/6/480
In samples of renal cell carcinoma, the high levels of CB2 receptors suggest them as both a prognostic marker & perhaps even a potential therapeutic target
Clinical Importance of Cannabinoid Type 1 Receptor (CB1R) and Cannabinoid Type 2 Receptor (CB2R) Expression in Renal Cell Carcinoma
https://pubmed.ncbi.nlm.nih.gov/38420293/
And in eye cancer cells, a drug that activates the CB1 & NGF receptor helped to learn about the evolution of treatment resistance
Joint CB1 and NGF Receptor Activation Suppresses TRPM8 Activation in Etoposide-Resistant Retinoblastoma Cells
https://pubmed.ncbi.nlm.nih.gov/38339011/
Synthetic Cannabinoids
In forensic science, the challenges of evaluating these synthetic cannabinoids
Chemical and pharmaceutical research of cannabinoids as objects of forensic examination
https://dspace.nuph.edu.ua/handle/123456789/32292
A case report of prolonged psychosis after synthetic cannabinoid usage
New-Onset Prolonged Psychosis Following Synthetic Cannabinoid Use in an Older Patient: A Case Report
https://europepmc.org/article/med/38449474
In France, the 37 cases of HHC poisoning reported to the poison centers
Hexahydrocannabinol poisoning reported to French poison centres
https://pubmed.ncbi.nlm.nih.gov/38426845/
In mice, an analysis of the behavioral effects & endocannabinoid changes to 3 synthetic cannabinoids (MDMB-CHMINACA, 5F-ADB-PINACA & APICA)
Timeframe Analysis of Novel Synthetic Cannabinoids Effects: A Study on Behavioral Response and Endogenous Cannabinoids Disruption
https://www.mdpi.com/1422-0067/25/6/3083
The toxic effects of two synthetic cannabinoids seem to be mediated by serotonin receptors
5-HT2A receptors are involved in the pharmaco-toxicological effects of the synthetic cannabinoids JWH-018 and 5F-PB22: In vivo studies in mice
https://www.sciencedirect.com/science/article/pii/S0014299924001742
The metabolism of the synthetic cannabinoid CH-PIATA
Insights into the metabolism of CH-PIATA - a novel synthetic cannabinoid featuring an acetamide linker
https://pubmed.ncbi.nlm.nih.gov/38441323/
Cool Chemistry & Tools
A recipe for the easy synthesis of other cannabinoids from CBD
Easy and Accessible Synthesis of Cannabinoids from CBD
https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.3c01117
And a molecular modeling study on converting CBD into other cannabinoids
A Molecular Modeling Study into Brønsted and Lewis Acid Catalyzed Conversion of CBD into Other Cannabinoids
https://www.mdpi.com/2673-8449/4/1/6
CBD in a hydrogel matrix to allow for its use as a scaffold for tissue & cellular regeneration
Cannabidiol-loaded microparticles embedded in a porous hydrogel matrix for biomedical applications
https://pubmed.ncbi.nlm.nih.gov/38353746/
On using marine bacteria to produce cannabinoids
Discovery of Latent Cannabichromene Cyclase Activity in Marine Bacterial Flavoenzymes
https://pubs.acs.org/doi/abs/10.1021/acssynbio.4c00051
Thanks.
- lex
PS: From the great Brazilian pop star, his album ‘Sérgio Mendes' Favorite Things’ (on this album, I love the first track as well as ‘Comin’ Home Baby’). Beginning his musical studies with classical piano as a young boy, he was living in Rio in the ‘50s when bossa nova hit the scene & he jumped into the craze with local heroes like João Gilberto & visiting luminaries like Stan Getz, Dizzy Gillespie, Charlie Byrd & Herbie Mann. By the ‘60s, he moved to NYC & started his group Brasil ’66. Their first albums yield a bumper crop of hits & he became perhaps the best-known Brazilian performer in the world. And since then, it’s been 50 straight years of producing new tunes & expanding his repertoire & pushing his own boundaries.
This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.