Canna for OCD, PTSD, intense skin blistering, fibro, lower back pain & burning mouth syndrome oh my
Harm reduction is vital + hat’s off to Filter!
Cannabinoids & The People,
or; Drugs & Drug Wars
🌟 This week 🌟
(#hashtags for jumping to articles by searching for them with your browser)
Cannabis for epidermolysis bullosa (an intense skin blistering disease)
CBD for OCD + burning mouth syndrome
THC for PTSD
THC + CBD for fibro + lower back
CBD & drug-drug interactions (my short rundown at #liverenzymes)
For CHS, capsaicin cream for the retching + blood markers show an activated immune system
Preclinical: CBD for menopause + THC & OEA for obesity + CBG & CBD for fatty liver + CBD & THC for HIV brains
Preclinical harms: 2 on THC bad for the bones of menopause
Reviews: acidic cannabinoids + minor cannabinoids
On hemp underwear with fragrances for odor management (#underwear)
Harm reduction: my backlash against the backlash against harm reduction, including quotes from my best friend who’s in the know (#harmreduction) + a tip of the hat to all the great harm reduction journalists at Filter & thanks for all of your Good Work!
[numbers for C&P#196: 9.5k words, 26 minutes reading time, 187 papers]
📌 Editor’s notes 📌:
- I got interviewed by my old buddy Joe Dolce on the paracannabinoids (PEA for immunity, oleamide for sleep & oleoylethanolamide for appetite) as well as CHS & CUD. I love the smell of acronyms in the morning.
- An extra push for the Portugal Medical Cannabis Conference in 3 weeks. It’s the last conference I can go to this year & I’m so excited for it. Laura Ramos (of CannaReporter fame) puts on a helluva show & I hope to see you all there.
- Thanks to JBoogie22 for buying me 5 coffees. At my current usage, that’s about 2.5 days of work, so much appreciated!
Hello everyone,
Welcome to the 196th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science, assorted canna-news + the War on Drugs, harm reduction & other psychoactives. Support this work with a paid subscription or by buying me a coffee. If you purchase one of my canna-graphic novels based on Moby Dick, proceeds go to Americans for Safe Access to support medical cannabis patients.
For producing cannabinoid content, work with my company White Whale Creations: writing, science archives, social media, newsletters & podcasts.
As always, ask me anything!
🤝 Sponsor 🤝: Portugal Medical Cannabis Conference
PTMC 2026 brings the international medicinal cannabis community back to Lisbon!
The 8th edition of PTMC – Portugal Medical Cannabis will take place on 10–11 September 2026 at the Lisbon Academy of Sciences, bringing together international experts, researchers, healthcare professionals, policymakers and industry leaders to discuss the future of medicinal cannabis in Portugal and across Europe.
With an intimate format limited to 250 participants, PTMC 2026 will address some of the sector’s most pressing topics, including investment and supply chain efficiency, cultivation and post-harvest practices, EU-GMP and quality, scientific research, women’s health, patient access and the evolving European regulatory landscape.
The programme will open with “7 Years of Medicinal Cannabis in Portugal – What’s Next?” and conclude with the policy debate “Cannabis Policy in Europe: Is Portugal Falling Behind?”, bringing together political representatives from the Parliament and experts to discuss Portugal’s position within a rapidly changing European market.
On 9 September, ahead of the main conference, PTMC will also host a dedicated programme for healthcare professionals and patients, including medical cannabis training and an open consultation session.
Organised by CannaReporter®, PTMC has established itself as an international meeting point for science, healthcare, policy and industry, with networking remaining at the heart of the experience.
Programme, speakers, registration and more info at PTMC.PT.
🎥 Lex’s new work 🎤
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Canna-edu videos sponsored by the National Cannabis Study (join & get paid $100 to talk about your use of our favorite plant)
Canna-science Videos for CV Sciences on YT @CVSciencesInc & on TT @pluscbd
For 30% off their CBD, THC & PEA products, at pluscbdoil.com use the coupon code ‘LEX’
[videos paused for the summer while I work on a video series about their lovely new PlusHLTH products]
@LexPelgerAndHisBooks on TikTok, YouTube & Instagram:
On your Own Mind & Testing Others: Confucius & Dr. Siu’s ‘The Dragon Within’ (love this I Ching quotes book!)
And as always, at the bottom is the album of the week: the scatting of Sheila Jordan
💖 Ways to support this work 💖
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📣 A request to spread the word 📣
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🍃 BEST OF CANNABINOID SCIENCE 🍃
(most of the phytocannabinoid data is here & most of the endocannabinoid data is in the ‘Canna-Science Archive’ at the bottom)
For Alzheimer’s disease & neuroinflammation, Neurotherapia has a CB2 drug that just successfully completed a phase 2a trial
https://cannabinoidpipelineinsights.substack.com/p/neurotherapia-inc-ntrx-07-and-its
⚕️ Clinical ⚕️
In people with epidermolysis bullosa (a genetic disease of extreme skin fragility), they reported that inhaled & topical cannabinoids improved pain & overall well-being, while in mouse models, inhibiting the enzyme MAGL (which breaks down the endocannabinoid 2-AG) reduced pain behaviors, inhibiting DAGL (which produces 2-AG) increased pain behaviors & the CB1 receptor inverse agonist Rimonabant increased pain 3-fold
‘Activating endocannabinoid pathways in epidermolysis bullosa to manage pain’
https://www.jidonline.org/article/S0022-202X(26)02340-7/fulltext
In people with obsessive-compulsive disorder, 25 mg of CBD for 2 months lowered OCD scores
‘Evaluation of Cannabidiol Effects as an Adjunctive Therapy on Symptoms of Patients with Obsessive–compulsive Disorder’
https://www.ovid.com/jnls/aips/fulltext/10.4103/aip.aip_67_25~evaluation-of-cannabidiol-effects-as-an-adjunctive-therapy
In people with burning mouth syndrome, full-spectrum CBD oil caused significant reductions in pain intensity & improvements of quality of life
‘Analgesic effect of full spectrum cannabidiol oil in burning mouth syndrome: randomized single-blind placebo trial’
https://www.sciencedirect.com/science/article/pii/S2212440326003834
In people with fibromyalgia, a 1:1 THC:CBD oil caused clinical benefits but did not alter endocannabinoid levels
‘Oral Medicinal Cannabis Does Not Alter Plasma Levels of Endocannabinoid-Related N-Acylethanolamines in Fibromyalgia Patients: Findings from a Randomized Placebo-Controlled Trial’
https://journals.sagepub.com/doi/abs/10.1177/25785125261469541
In people with lower back pain, the best combination seems to be equal amounts of THC & CBD, with higher doses of CBD perhaps lowering the painkilling effects of THC
‘Lower Pain Intensity Is Associated with the Use of Recreational Edible Cannabis Products Containing Delta-9-Tetrahydrocannabinol: A Secondary Analysis in Adults Self-Managing Their Chronic Low Back Pain’
https://www.mdpi.com/2227-9059/14/7/1642
In brain scans of people with PTSD, dronabinol (pharmaceutical THC) was associated with reduced activation during reappraisal of negative images
‘Dose-related reductions in prefrontal recruitment during cognitive reappraisal following oral delta-9-tetrahydrocannabinol in posttraumatic stress disorder’
https://www.nature.com/articles/s41386-026-02502-2
In children with epilepsy, CBD was associated with significant reductions in seizure frequency
‘Clinical Outcomes of Cannabidiol (CBD) Therapy in Pediatric Patients with Epilepsy’
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0046-1825935
In young people with drug-resistant epilepsy, CBD caused marked improvements in those with developmental & epileptic encephalopathies, but not for focal structural epilepsies
‘Effectiveness of Cannabidiol in Drug-Resistant Epilepsy: A Prospective Case Series’
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0046-1825893
In Ontario, Canada after legalization, public health data found people substituting cannabis for antidepressants, especially in females
‘Cannabis and Antidepressant Use During the Periods Before and After Cannabis Legalization in Ontario, Canada: 2013 to 2023’
https://journals.sagepub.com/doi/abs/10.1177/29767342261462867
In people with cancer using cannabis, a survey found the common benefits to be pain relief, improved sleep, physical relaxation, emotional regulation & reduction of pharmaceutical medication, with the biggest barriers being stigma against THC & the high cost of CBD & THC products
‘A Comparative Network Analysis to Explore Cancer Patient Experiences with Cannabis’
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1737119/abstract
For osteoarthritis, a meta-analysis of 26 studies found preclinical evidence for cannabinoids lowering inflammation, reducing pain & protecting the joint cartilage, but less positive human studies
‘Efficacy and Safety of Cannabis Extracts for the Treatment of Osteoarthritis: A Systematic Review and Meta-Analysis of Preclinical and Human Studies’
https://pmc.ncbi.nlm.nih.gov/articles/PMC13408433/
In people at clinical high-risk for psychosis, this thesis project found that 600 mg per day for 12 weeks of the paracannabinoid PEA associated with significant improvements in lessening symptoms & improved functional outcomes
‘Evidence for Endocannabinoid-Like Compound Supplementation for Human Health: Palmitoylethanolamide as a Potential Treatment in Clinical High-Risk for Psychosis’
https://tesidottorato.depositolegale.it/handle/20.500.14242/376330
In people with bipolar disorder, the cannabis users had better temporal perception & cognitive performance
‘Evidence for pro-cognitive benefits of cannabinoids in people with bipolar disorder’
https://www.nature.com/articles/s41386-026-02489-w
📑 Reviews 📑
A new book on cannabis by friends of the newsletter Dr. Jahan Marcu & Dr. Andrew Peterson
‘Demystifying Cannabis and Hemp’
https://www.degruyterbrill.com/document/doi/10.1515/9783111476162/html
In Canadian healthcare professionals, a review of 26 articles found that they endorsed use of cannabis primarily for chronic pain, pediatric & cancer nausea/pain, but many remained hesitant to consider cannabis because of limited knowledge, stigma, regulations, costs & insufficient clinical evidence
‘Understanding Healthcare Professionals’ Perspectives on Cannabis for Medical Purposes in Canada: A Scoping Review’
https://karger.com/mca/article-pdf/doi/10.1159/mca/adoag001/4567012/000553671.pdf
For CBC, a review of its biosynthesis, pharmacokinetics, actions in the body & preclinical evidence for therapeutic use
‘Cannabichromene (CBC): a comprehensive review of biosynthesis, pharmacology, therapeutic potential, and translational perspectives’
https://link.springer.com/article/10.1186/s42238-026-00454-4
For low-dose CBD, there were drug-drug interactions with THC, the opioid hydromorphone & the antidepressant amitriptyline, with scattered improvements in sleep disorders, alcohol use disorder & multiple sclerosis, but not a range of other diseases
‘Evaluating the pharmacokinetics, efficacy and safety of low-dose cannabidiol’
https://pubmed.ncbi.nlm.nih.gov/42473010/
For nociplastic pain (chronic pain from an altered nervous system instead of tissue damage/nerve injury), a review of 10 studies found limited data suggesting modest benefits from cannabis-based medicines for fibromyalgia & chronic musculoskeletal pain, “with improvements more evident for sleep, affective domains, and quality-of-life than for direct analgesia”
‘Cannabis-Based Medicines for Nociplastic Pain: A Scoping Review of Efficacy, Safety, and Patient Outcomes’
https://www.tandfonline.com/doi/pdf/10.1080/15360288.2026.2704788
On using THC, CBD or terpenes for pain, a review on their wide range of actions
‘Cannabinoid Efficacy for Pain: Dose, Chronicity and Route’
https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1888863/abstract
In people going through physical therapy & rehabilitation, this review looked at the limited evidence on meaningful improvements & the potential negative impacts
‘Therapeutic Use of Medical Cannabis Beyond Pain Management in Physical Medicine and Rehabilitation’
https://pmc.ncbi.nlm.nih.gov/articles/PMC13409867/
For the neuropharmacology of the cannabinoids, a comprehensive review of their preclinical & clinical evidence for various diseases
‘Neuropharmacology of Cannabinoids: A Comprehensive Review of Preclinical and Clinical Evidence for Hemp-Derived Extracts and Active Compounds’
https://www.mdpi.com/1424-8247/19/8/1151
For the psychiatric effects of CBD, THC & CBN, a review found no consistent clinically meaningful benefit for major psychiatric disorders & negative evidence for THC
‘Psychiatric effects of cannabidiol, cannabinol, and tetrahydrocannabinol: A narrative review of clinical evidence and risk profiles’
https://pmc.ncbi.nlm.nih.gov/articles/PMC13373943/
In oncology & the oral effects of cancer, a review on the potential of cannabinoids
‘Cannabinoids in Oral Medicine and Oncology: A Narrative Review of Mechanisms, Clinical Relevance, and Limitations’
https://openurl.ebsco.com/EPDB%3Agcd%3A9%3A15039849/detailv2?sid=ebsco%3Aplink%3Acrawler-gcd&id=ebsco%3Agcd%3A195297235&crl=c&jrnl=22241507&link_origin=none
For chronic liver disease, a review of the involvement of the endocannabinoid system & the preclinical evidence for CBD, THCV & CBG as well as the role of the gut microbiome
‘Cannabis and Liver Health: Exploring the Gut-Liver Axis and the Role of the Gut Microbiota’
https://www.sciencedirect.com/science/article/abs/pii/S2210803326000424
For liver diseases, a review on the importance of the CB2 receptor
‘Revisiting cannabinoid receptor-2: a key regulator of hepatic steatosis, inflammatory cascades, and fibrotic progression’
https://pubmed.ncbi.nlm.nih.gov/42474488/
For treating aging with the combination of the paracannabinoid PEA & the flavonoid luteolin, this review covered the promising preclinical evidence & preliminary clinical findings
‘Palmitoylethanolamide and Luteolin in Brain Aging and Cognitive Decline: Biological Rationale and Current Evidence’
https://www.preprints.org/manuscript/202607.2125
For osteoporosis & depression, an editorial on targeting the endocannabinoid system
‘Might modulation of the endocannabinoid system provide a potential dual therapeutic strategy for osteoporosis and depression?’
https://pmc.ncbi.nlm.nih.gov/articles/PMC13379771/
For acidic cannabinoids, a review of where they bind, how they move through the body & how they’re broken down
‘Stomach Acid, Blood pH, and Liver Metabolism: The Stability and Transformation of Acidic Cannabinoids’
https://www.preprints.org/frontend/manuscript/11f3b82427d7bfa600f799c1169eadf8/download_pub
For the minor cannabinoids, a review on their isolation, proposed biosynthesis pathways & reported biological activities
‘Synthetic Strategies Enabling Access to Minor Phytocannabinoids of Cannabis sativa L.’
https://www.scielo.br/j/jbchs/a/8Fj4KdJKxPnYGBsh9mMy78P/
For cannabis roots, a review on the 500+ compounds as well as their antioxidant, anti-inflammatory & antimicrobial activities
‘Phytochemistry, bioactivity, and medicinal use of Cannabis sativa roots: a comprehensive review’
https://themarijuanaherald.com/wp-content/uploads/2026/07/s42238-026-00470-4_reference-1-1.pdf
On the enzyme MAGL (which breaks down the endocannabinoid 2-AG), a review on targeting it for human diseases
‘Advances in Small Molecule Research Targeting Monoacylglycerol Lipase in Drug Discovery’
https://pubmed.ncbi.nlm.nih.gov/42478312/
In our Neural Ocean metaphor, this MAGL enzyme is a giant squid that chops up the beautiful endocannabinoid blue whales 2-AG.
⚠️ Harms ⚠️
In breast-fed infants whose mothers use cannabis, their urine contained higher levels of volatile organic compounds
‘Volatile Organic Compound Metabolites Are Found in the Urine of Breastfed Infants Whose Mothers Use Cannabis: The Lactation and Cannabis (LAC) Study’
https://www.mdpi.com/1660-4601/23/7/905
In women of reproductive age, cannabis use (as well as tobacco use) was associated with higher blood levels of lead & cadmium
‘Cigarette smoking and marijuana use are associated with higher blood lead and cadmium levels among women of reproductive age: NHANES 2005-2018’
https://apha.confex.com/apha/2026/meetingapi.cgi/Paper/595820?filename=2026_Abstract595820.pdf&template=Word
For suicidality in US high schoolers, a meta-analysis found cannabis users had doubled odds of suicidal ideation & a suicide attempt
‘Association Between Marijuana Use and Suicidality in US High-Schoolers: A Scoping Review’
https://digitalscholarship.fiu.edu/record/133
In youth with bipolar disorder & those without bipolar disorder, the cannabis users had even smaller volumes of their left thalamus (brain relay station of sensations)
‘Prospective Volumetric Changes in the Thalamus in Adolescent First Episode of Mania and Cannabis Use: A Preliminary Study’
https://pmc.ncbi.nlm.nih.gov/articles/PMC13378242/
In a young person with cannabinoid hyperemesis syndrome, a topical capsaicin cream on the stomach had his retching cease within 10 minutes & pain resolve within 90 minutes
‘Successful Management of Refractory Cannabinoid Hyperemesis Syndrome With Topical Capsaicin: A Case Report With Proposed Mechanism of Action and Literature Review’
https://journals.sagepub.com/doi/full/10.1177/11795476261470568
In people with suspected cannabinoid hyperemesis syndrome, their blood had markers of an activated adaptive immune system
‘Whole-blood transcriptomic findings in emergency department patients with suspected cannabinoid hyperemesis syndrome: a pilot study’
https://link.springer.com/article/10.1186/s42238-026-00477-x
“Suspected CHS was associated with marked activation of the adaptive immune system, including upregulation of B-cell related immunoglobin transcripts and altered expression of T cell, monocyte, and neutrophil-related transcripts. DEGs also suggested increased matrix degradation, and reduced adhesion and protease inhibitor transcripts. Digital HLA isotyping revealed increased MHC Class I expression, Class II allele restriction, and down-regulation of IgE receptor transcripts, a known response to elevated IgE levels in allergic hypersensitivity.”
In Swiss people with THC use disorders, they had higher levels of small airway dysfunction
‘Association between small airways dysfunction and THC use disorders in the general Swiss population’
https://www.sciencedirect.com/science/article/pii/S0954611126004221
For cannabis use disorder, a meta-analysis of 5 medication trials found that males were more likely to benefit than females, especially with medications targeting serotonergic or nicotinic pathways
‘Sex differences in cannabis use disorder study outcomes: An aggregated secondary analysis of medication trials’
https://www.sciencedirect.com/science/article/pii/S0376871626002668
In people with cocaine use disorder being treated with naltrexone & buprenorphine, cannabis use was linked to higher odds of cocaine use during treatment
‘Relationships between cannabis and cocaine use in a randomized trial of combined buprenorphine and naltrexone for DSM-IV cocaine dependence’
https://www.sciencedirect.com/science/article/pii/S0306460326002273
For gambling, this thesis project found that people under the influence of cannabis risked more money, gambled for longer periods of time & placed more bets
‘Gambling Under the Influence of Cannabis: The Impact of Simultaneous Engagement Within Individuals Who Gamble Frequently’
https://www.proquest.com/openview/012c86365ded727eb9011e8bd8de128a/1
A Turkish case report of spontaneous pneumomediastinum (air in the chest cavity) “caused by marijuana addiction”
‘A breathtaking truth: A case of spontaneous pneumomediastinum caused by marijuana addiction’
https://addicta.com.tr/article/view/519
For the eyes of cannabis users, an AI-based study found altered retinal morphology with potential links to increased glaucoma risk
‘Morphological features extracted from color fundus photography indicate potential changes due to cannabis consumption’
https://iovs.arvojournals.org/article.aspx?articleid=2818324
In a rat model of osteoporosis via estrogen deficiency, inhaled THC worsened bone microarchitecture
‘Chronic Δ9-Tetrahydrocannabinol Inhalation Following Osteoporosis Results in Bone Deficits’
https://www.mdpi.com/2227-9059/14/7/1620
In a female rat model of osteoporosis due to induced menopause, inhaled THC as an adolescent caused a significant later decrease in bone volume
‘Chronic THC Inhalation During Early Adulthood Exacerbates Ovariectomy-Induced Bone Loss in a Rat Model of Osteoporosis’
https://www.mdpi.com/2227-9059/14/8/1687
🐁 Preclinical 🐁
In a mouse model of late infantile neuronal ceroid lipofuscinosis (CLN2 disease, a rare pediatric neurodegenerative disorder of the lysosomes (cellular recyclers)), long-term CBD treatment delayed or fully eliminated seizures
‘Chronic oral cannabidiol delays seizure onset and reduces seizure burden in a mouse model of CLN2 disease’
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0337880
In a rat model of menopause, CBD improved memory & improved endocannabinoid levels similar to hormone therapy with estradiol
‘Effects of cannabidiol in comparison to hormonal therapy on estrogen decline-induced memory impairments and endocannabinoid system in rats’
https://pmc.ncbi.nlm.nih.gov/articles/PMC13385457/
“Overall, the findings suggest that CBD exerts a protective effect on memory comparable to standard estrogen therapy, supporting its therapeutic potential for menopause‐related cognitive impairments.”
In an aged mouse model of HIV, chronic CBD improved recognition memory in female mice & restructured the endocannabinoid signaling landscape across the brain in a gendered manner
‘Chronic CBD treatment differentially modulates neurobehavioral outcomes and endocannabinoid signaling in an aged HIV-1 Tat transgenic mouse model’
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0353267
In a mouse model of HIV-associated neurocognitive disorder, THC modulated neuroinflammation & altered the architecture of excitatory & inhibitory neurons across the brain, “suggesting restoration of neural balance underlying cognition and memory”
‘Spatial transcriptome mapping to decode Cannabinoid-mediated neuroprotection in HIV-1 gp120—induced degenerating mouse brain’
https://academic.oup.com/jimmunol/article/215/Supplement_1/vkag141.287/8744323
In a mouse model of Alzheimer’s disease, nanoparticles of CBD & albumin outperformed CBD isolate for inhibition of plaque Aβ aggregation, reactive oxygen species generation & inhibition of neuronal toxicity, with doubled cellular uptake
‘Modified self-assembled cannabidiol–albumin nanoparticles for enhanced brain delivery and neuroprotection in an Alzheimer’s model’
https://link.springer.com/article/10.1007/s40005-026-00820-7
In a mouse model of memory loss due to disease, CBD disrupted memory reconsolidation but not consolidation via BDNF (a key brain growth factor) in the hippocampus (a memory center of the brain)
‘Differential Effects of Cannabidiol on Inhibitory Avoidance Memory Reconsolidation and Consolidation Are Associated with Distinct Hippocampal proBDNF and BDNF Signaling Profiles’
https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1915561/abstract
In a hamster model of drug-resistant epilepsy, CBD reduced seizure severity & increased the time between seizures, with more efficacy in females
‘Anticonvulsant Effects, Safety, and Sex-Dependent Molecular Signatures of Cannabidiol Treatment in a Preclinical Model of Audiogenic Epilepsy’
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1745696/abstract
In a mouse model of metabolic associated steatotic disease (formerly known as fatty liver disease), the combination of CBG & CBD improved T cell activation & the production of anti-inflammatory cytokines
‘Mast Cell and TGF-β interactions in a model of Metabolic Dysfunction-Associated Steatotic Liver Disease and responses to cannabinoid intervention’
https://academic.oup.com/jimmunol/article/215/Supplement_1/vkag141.101/8745102
In a mouse model of diet-induced obesity, THC-rich cannabis for 4 weeks partially restored lean-like profiles & a beneficial gut microbiome
‘Cannabinoid Modulation of Intestinal and Neuroimmune Dysregulation in Diet-Induced Obesity’
https://academic.oup.com/jimmunol/article/215/Supplement_1/vkag141.1711/8745162
In a rat model of obesity due to a high-fat diet, the paracannabinoid oleoylethanolamide prevented the alterations to their skeletal muscle metabolism via changes to lipid metabolism, tissue remodeling & the mitochondria (powerhouse of the cell)
‘Oleoylethanolamide attenuates early skeletal muscle metabolic remodeling induced by short-term high-fat diet exposure’
https://www.sciencedirect.com/science/article/pii/S1043661826002653
In a rat model of rheumatoid arthritis, CBD alleviated joint inflammation & structural bone destruction via HIF-1α & VEGFA/ANG-2
‘Ubiquitin-proteasome-dependent degradation of HIF-1α by cannabidiol disrupts pro-angiogenic synoviocyte-endothelial crosstalk in rheumatoid arthritis’
https://www.sciencedirect.com/science/article/pii/S0944711326008925
In mouse models of PTSD, an analysis of genetic transcription found 7 targets responsive to CBD treatment across the prefrontal cortex & the hippocampus (a memory center of the brain)
‘Cross-species causal gene mapping reveals brain-region-specific targets of Cannabidiol for post-traumatic stress disorder treatment’
https://www.sciencedirect.com/science/article/abs/pii/S0006291X26011113
In a rat model of neuropathic pain treated by electroacupuncture, they had increased levels of the CB2 receptor in the spinal cord’s microglia (guardian immune cells of the brain) via p38 MAPK & PI3K/AKT signaling
‘Low-frequency electroacupuncture alleviates neuropathic pain via cannabinoid receptor type 2 signaling in the spinal cord dorsal horn’
https://www.sciencedirect.com/science/article/abs/pii/S2095496426000890
This joins a long, long line of work linking acupuncture to the endocannabinoid system…
In a tissue model of neural differentiation, CBD caused a significant upregulation of neural marker genes
‘Cannabidiol Drives Efficient Neural Differentiation of Human Wharton’s Jelly Mesenchymal Stem Cells: A Small-Molecule Approach for In Vitro Neurogenesis’
https://www.biotechrep.ir/article_247500_12f9a054d1be54605209b959cfbe0d58.pdf
In a rat model of bipolar disorder, the terpene beta-caryophyllene lessened behavioral abnormalities, reduced oxidative damage & prevented neuronal degeneration
‘Beta-Caryophyllene Prevents Ouabain-Induced Neurodegeneration and Behavioral Alterations Through PKA/GSK-3β Pathway’
https://pmc.ncbi.nlm.nih.gov/articles/PMC13384979/
In a zebrafish model of anxiety, the terpene α-humulene had low toxicity & produced a maximal anxiety-reducing effect at an intermediate dose via both the neurotransmitters serotonin & GABA (the brain’s most common inhibitory neurotransmitter)
‘Assessment of the Acute Toxicity and Anxiolytic-Like Effect of α-Humulene in Adult Zebrafish (Danio rerio)’
https://pmc.ncbi.nlm.nih.gov/articles/PMC13401976/
On the cytochrome P450 enzymes (liver enzymes responsible for both clearing & activating drugs that enter our bodies), an analysis of which ones are most affected by CBD (especially CYP2C19 activity was inhibited) (#liverenzymes)
‘Effects of Simulated Exogenous and Endogenous Lipid Microenvironments on Cannabidiol Disposition and Cytochrome P450 2C19-Mediated Drug Interactions: New Mechanistic Insights’
https://www.sciencedirect.com/science/article/pii/S0090955626006446
The most famous CYP2C19-altered drugs are clopidogrel (Plavix, which gets activated by it), as well as the ones that get broken down by it (thus becoming more potent with CYP2C19 inhibition), including the proton pump inhibitors omeprazole (Prilosec) & esomeprazole (Nexium), the antidepressants citalopram (Celexa), escitalopram (Lexapro) & sertraline (Zoloft) & lastly the benzodiazepine Valium. That being said, there’s a long list of simulated liver studies like this showing effects but the lists of case reports and clinical studies are not nearly so long. So while CBD may have an effect here, I suspect it’s often not enough to knock things out of the range of normality.
I can share my whole liver drug-drug interactions file with anyone who wants to see it, but the most solid clinical data for overall CBD drug-drug interactions includes the benzodiazepine clobazam (Onfi), caffeine (makes it slightly stronger), opioids (minor effects), the antidepressant medications citalopram/escitalopram & amitriptyline, some of the anti-epileptic medications like stiripentol, of course the blood thinner medication warfarin (I had an old boss who said everything screws with warfarin), the cancer treatment tamoxifen (which gets weaker with inhibition) & finally, a case report each for methadone, lithium & the immunosuppressant tacrolimus.
🆕 Novel Studies 🆕
(my grab bag section for stuff I haven’t quite seen before)
In a cannabis consumption lounge, a case study found higher levels of black carbon, cannabinoids & PM2.5 (airborne particulate matter)
‘Chemical Constituents and Oxidative Potential of Fine Particulate Matter in a Cannabis Consumption Lounge: A Case Study’
https://pubs.acs.org/aeacd5/article-abstract/doi/10.1021/acsestair.6c00144/5211403/Chemical-Constituents-and-Oxidative-Potential-of
On influencers normalizing intoxicating hemp products for youth
‘Influencer-driven lifestyle and wellness framing of intoxicating hemp products may normalize youth cannabis use’
https://www.sciencedirect.com/science/article/abs/pii/S0955395926002781
“In ongoing monitoring of Instagram posts from leading DICP brands, we observed influencer posts that featured young-looking creators, aspirational wellness imagery, humor, slang, fast-cut editing, mocktail-making scenes, and claims positioning DICPs as “hangover-free,” safer, or substitutes for alcohol or other drug use. Such content may reduce perceived risk, increase product appeal, and normalize cannabis use, particularly when promotional posts resemble organic (non-promotional) peer-culture content rather than advertising.”
📰 US Headlines & Fav Articles 📰
Instead of covering all of the latest dish on the looming federal hemp ban, I’ll give you the always relevant musings of Marc Hauser
https://cannabismusings.substack.com/p/cannabis-musings-august-10-2026
In Idaho, more than 1000 new mothers put on to child abuse registries, often from just one positive THC test
https://www.cbsnews.com/news/thc-tests-land-new-mothers-onto-child-abuse-registries/
Let me be clear that I think this is an abomination & it’s everything that makes me use my pen to fight the horrors of the War on Drugs.
A short bio of endocannabinoid hero & Nobel Prize winner Dr. Rita Levi-Montalcini who overcame antisemitic discrimination in Mussolini’s Italy to make key discoveries of brain growth as well as the mechanism of action for our beloved paracannabinoid PEA
‘From the Scientific Underground to the Height of Recognition: The 40th Anniversary of Rita Levi-Montalcini’s Nobel Prize and the Promising Horizon in Psychiatry’
https://link.springer.com/article/10.1007/s11064-026-04769-9
🌐 International News 🌐
In Panama, the region’s first medical cannabis law passed in 2021 & the first legal sale happened this year
https://cannabislaw.report/article-panama-finally-sells-cannabis-it-took-four-years-and-one-very-bad-decree/
In France (where I lay my head), the fine for cannabis possession is going from €200 to €500
https://www.hanf-magazin.com/recht/rechtslage-international/frankreich-erhoeht-die-cannabis-geldstrafe-auf-500-euro-was-das-ripost-gesetz-bedeutet/
Wrong direction France. But your harm reduction programs are so good, that I guess I’ll have to let it pass.
In French Polynesia, their low-THC medical cannabis program is finally planting the first seeds
https://cannabislaw.report/french-polynesia-ready-to-launch-its-medical-cannabis-pilot-program-after-delays/
In the Democratic Republic of Congo, a former militia commander alleged that in its vast criminal economy, “the United Nations peacekeeping mission, MONUSCO, were its biggest cannabis customers”
https://www.cannabiz-africa.com/blog/un-peacekeepers-were-our-biggest-buyers-drc-rebel-leader-details-how-cannabis-sustained-anti-govt-militia
In Uttarakhand, India, an anthropological chapter on the long human history with hemp
‘An Anthropological Study of Affective Relations between Humans and Hemp in Uttarakhand’
https://www.asssr.in/index.php/jasssr/article/view/302
In Pakistan, interviews & an analysis of their shift toward medicinal & industrial cannabis cultivation
‘From Prohibition to Regulation: Socio-Economic Determinants of Cannabis Production in Orakzai District, Khyber Pakhtunkhwa, Pakistan’
https://reviewcps.com/index.php/rcps/article/view/57
⚖️ Business, Laws & Education ⚖️
Curaleaf (US-based) launches hostile takeover of Aurora (Canada-based)
https://ir.curaleaf.com/2026-08-11-Curaleaf-Announces-Intention-to-Launch-Take-Over-Bid-for-Aurora-Cannabis-to-Solidify-its-Position-as-the-Global-Cannabis-Industry-Leader
The main reason I care is because I find hostile takeovers fascinating, a la ‘Barbarians At the Gate’.
Relatedly, the FBI examined Curaleaf over money laundering & public corruption, but grand juries in Manhattan & Philadelphia both closed without charges
https://thenewsground.com/fbi-investigated-curaleaf-for-corruption-and-money-laundering/
The cowards at Square will stop processing sales of hemp & CBD products because of the (potential) upcoming federal ban
https://www.marijuanamoment.net/square-tells-businesses-to-stop-selling-hemp-and-cbd-products-in-light-of-upcoming-federal-ban/
For agricultural labor markets, adult-use cannabis laws increased employment by 9%
‘Retail Recreational Marijuana Legalization and Agricultural Labor Markets: Evidence from Synthetic Difference-in-Differences’
https://econpapers.repec.org/paper/agsaaea26/404370.htm
For Australian policy on higher THC concentration products, a review of 76 publications analyzed policy approaches from 5 other countries on dosage limits, packaging requirements & education
‘International Policy Approaches for Higher THC Cannabis Products: Are They Applicable to the Australian Medicinal Cannabis Framework?’
https://pubmed.ncbi.nlm.nih.gov/42454543/
For cannabis containing products in the US, a review of product evaluation framework & risk management
‘An integrated, iterative risk assessment framework for cannabis-containing products: Development and application’
https://www.sciencedirect.com/science/article/pii/S0273230026001571
Using an experimental cannabis marketplace, on the validity of it for analyzing behavioral economic indices
‘Preliminary validation of an experimental cannabis marketplace and its psychometric properties against an established measure of cannabis demand’
https://www.sciencedirect.com/science/article/abs/pii/S0376871626002619
🚗 Driving 🚗
After cannabis legalization in Connecticut, people in fatal motor vehicle accidents had their blood cannabinoid positivity increase, especially in pedestrians
‘Cannabinoid Positivity in Traffic Fatalities Before and After Cannabinoid Legalization A Retrospective Analysis in Connecticut (2018-2024)’
https://www.ovid.com/jnls/amjforensicmedicine/abstract/10.1097/paf.0000000000001151~cannabinoid-positivity-in-traffic-fatalities-before-and
For driving & cannabis use among older adults, those who were driving within 4 hours of consuming cannabis tended to have an earlier age of onset of cannabis use, higher self-ratings of perceived cognition/driving competence & to be holding a medicinal cannabis prescription
‘Cannabis, self-ratings of cognition and driving behaviour among older adults: an exploratory study’
https://www.sciencedirect.com/science/article/pii/S1369847826002287
In Canadians driving under the influence of cannabis, a survey of their risk perceptions
‘Driving under the influence of cannabis (DUIC): A risky proposition?’
https://www.sciencedirect.com/science/article/pii/S2214140526001532
🚓 The War on Drugs 🚓
Extensive report on a network of Mexican cartels around the world and their expansion into various industries, as well as teaching local crime groups to expand there too
https://www.brookings.edu/articles/the-spiking-threat-mexican-cartels-in-europe-canada-africa-the-asia-pacific-and-latin-america/
On the Colombian island San Andrés & Providencia, fishermen missing due to Trump’s boat strikes
https://www.aol.co.uk/articles/two-arrested-connection-death-us-171237000.html
“Stephens said that if such a large number of people had gone missing anywhere else in the world, “that would set off alarm bells. Yet here nobody pays attention, and young men continue to disappear.”
In Singapore, a 79-year-old stateless man executed by hanging for heroin trafficking
https://cannabislaw.report/singapore-hangs-79-year-old-stateless-man-convicted-of-heroin-trafficking/
An intriguing-looking book on hashish smuggling between Africa & Europe
https://psychedelicpress.substack.com/p/pipe-dreams
In Northern Ireland, 2 men on a ferry arrested with £375k of cannabis after a smell detected coming from their van
https://cannabislaw.report/uk-two-charged-over-large-cannabis-seizure-after-port-police-detect-smell-from-van/
History Corner: for US anti-narcotics efforts in Colombia, on the 1990 meeting between GWH Bush & Trujillo that opened with positive news about carnations
‘Buds and Drugs: The Power of Flowers in US-Colombian Anti-narcotics Efforts’
https://academic.oup.com/dh/advance-article-abstract/doi/10.1093/dh/dhag041/8735119
WoD Research
In Mexico after the start of anti-cartel military interventions, the municipalities experiencing interventions did not have the intended reduction in lethal violence but instead a higher rate of both total & cartel-related homicides
‘The Association between Anti-cartel Military Intervention and Municipal Homicide Rates in Mexico, 2000–2022’
https://link.springer.com/article/10.1007/s10940-026-09682-6
In Colombia after the start of coca farm eradication & the increased targeting of cocaine production facilities in 2007, the country experienced a 2.5% increase in legal agricultural production
‘The effect of drug eradication policies on agriculture in Colombia’
https://academicjournals.org/journal/JDAE/article-full-text-pdf/FD730CF74624
For narcoterrorism in Brazil, an analysis of the history & potential multidimensional approach
‘ANÁLISE DOS IMPACTOS DO NARCOTERRORISMO NAS ÁREAS DE DEFESA E SEGURANÇA PÚBLICA DO BRASIL NO ATUAL CONTEXTO GEOPOLÍTICO’
https://aurumpublicacoes.com/index.php/editora/article/view/1942
On how transnational drug-trafficking organizations reshape politics
‘The Price of Protection: Exploring How Transnational Drug Traffickers Influence Politics’
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/6DF31A39535A6C57EB901D2EB54D703F/S0003975626100423a.pdf/price_of_protection_exploring_how_transnational_drug_traffickers_influence_politics.pdf
🛡️ Harm Reduction News 🛡️
Another backlash piece against harm reduction in the Atlantic (#harmreduction)
https://www.theatlantic.com/magazine/2026/09/city-drug-addiction-harm-reduction-policy/687967/
And a Filter interview on what it’s like for harm reduction workers to see crackdowns rise again in SF & the rise of authoritarian systems like the Reset Center against the decline of treatment availability for substance use disorders
https://filtermag.org/san-francisco-harm-reduction-therapy-backlash/amp/
The problem with this Atlantic piece & the others of its ilk that have popped up over the last year is that they flatten many social issues into one problem of drug use. In my current home of France, they have an excellent & mostly unremarked upon national harm reduction program. But I think it works so well because the social safety net is mostly strong (of course, the French will argue this, but they were born to argue. My mother-in-law was shocked last year to hear that a surgery was going to cost over 100 euros out of pocket. Sometimes people don’t know how good they have it). It’s similar in harm reduction leaders like Switzerland. But in the US, if you’re on the street, you are left there to rot & die. One of the only logical responses is drug use to ease the burdens of no hope & no help.
Many of these harm reduction programs positioned themselves as “evidence-based” because of the moderate amount of research on their efficacy. But now more contradictory data is coming out showing otherwise, some of it surely biased politically, but some of it probably not. However, the thing about harm reduction isn’t only the evidence itself, but what it captures & what it doesn’t. As my best friend & harm reductionist Kat V points out, “I take issue with the application of that research into programs because it can flatten harm reduction down into statistical heavy services like how many vials of Narcan have been distributed or how many needles. To me, the biggest value in harm reduction is the ‘meet people where they’re at’ part through which harm reduction service providers can build relationships and show care and support. I think that’s ultimately more healing than the number of needles handed out but that connection is hard to capture in the research and so I think it gets washed out in favor of services that are easier to document numerically.” She adds that the thing to remember is “people who use drugs and live on the street as still being our neighbors who deserve humane and loving support.”
And as I say, it’s clearly right to not let people die if you can prevent them from dying.
I stand with harm reduction.
Filter to shut down. Blessings upon everyone who worked there, you were doing the Lord’s work
https://filtermag.org/a-statement-about-filter/
Harm Reduction Research
In Ontario, on the closing of their first official supervised drug consumption site
‘Dismantling harm reduction funding in Ontario: Safe consumption sites and the organized abandonment of people who use drugs’
https://journals.sagepub.com/doi/pdf/10.1177/08969205261463743
For the US harm reduction workforce, a survey found high levels of emotional drain & intent to quit
‘Burning out and walking out: Emotional drain and attrition intent in the U.S. harm reduction workforce’
https://apha.confex.com/apha/2026/meetingapi.cgi/Paper/598476?filename=2026_Abstract598476.html&template=Word
For improving attendance at a substance use disorder group treatment, financial incentives improved attendance while being under surveillance reduced participation
‘Strategies to increase attendance in substance use disorder group treatment: results from a randomized controlled trial’
https://link.springer.com/article/10.1186/s12954-026-01425-x
For new psychoactive substance poisonings in the Netherlands, an analysis of the last 14 years found the majority to be cathinone, phenethylamines & benzodiazepines, with 176 new types of drugs reported last year
‘Trends in new psychoactive substance poisonings in the Netherlands: A 14-year retrospective analysis (2012-2025)’
https://europepmc.org/article/med/42411193
🍄 Psychoactives, Psychedelics & Plant Medicines 🍄
On psychedelic non-responders with Rachel Ham
https://themicrodose.substack.com/p/why-dont-some-people-respond-to-psychedelics
Psychedelics & MDMA
For PTSD, a review on the use of psychedelics
‘Psychedelic Therapies in the Management of Post-Traumatic Stress Disorder: A Narrative Review’
https://apcz.umk.pl/JEHS/article/view/73071
Ketamine
In men with bladder problems from ketamine use, the majority reported sexual health issues including frequent erectile dysfunction & ejaculatory dysfunction
‘Ketamine abuse also affects sexual health’
https://academic.oup.com/smoa/article/14/5/qfag049/8740066
For adolescents in the ER for suicidal ideation or depression, low-dose IV ketamine was not associated with improvements
‘Intravenous Ketamine for Depressed and Suicidal Adolescents in the Emergency Department: A Randomized Double-Blind Trial’
https://escholarship.org/uc/item/5tn883t4
When using ketamine or esketamine for treatment-resistant depression, this cohort study found no significant increase in liver enzyme levels
‘Hepatic Safety of Ketamine and Esketamine for Treatment-Resistant Depression: A Real-World Cohort Study’
https://www.ovid.com/jnls/psychopharmacology/abstract/10.1097/jcp.0000000000002228~hepatic-safety-of-ketamine-and-esketamine-for
Kratom
For kratom products in the US, a secret-buyer analysis found frequent inconsistencies between labeled & actual contents
‘Mislabeling and Status of Semisynthetic Kratom-Derived Products in the US Market’
https://pubmed.ncbi.nlm.nih.gov/42448619/
In someone using kratom, a case report of visual snow & nyctalopia (night blindness)
‘Visual Snow-Like Symptoms, Ellipsoid Zone Disruption, and Outer Retinal Pigmentary Changes in a Patient with Chronic Kratom Use: A Case Report’
https://www.ovid.com/jnls/retinalcases/abstract/10.1097/icb.0000000000001959~visual-snow-like-symptoms-ellipsoid-zone-disruption-and
For kratom in the US, a review of 43 studies found the common motivations for use to be pain relief, mental health, substance withdrawal & for the enhancement of energy or mood, but with negatives including cravings, tolerance, GI symptoms & withdrawal
‘Mapping the Evidence on Kratom Use, Health Outcomes, and Policy Gaps in the United States: A Scoping Review’
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2697988
For the toxicity of kratom, a review found respiratory depression with variable responsiveness to naloxone
‘Kratom Toxicity: Pharmacologic Mechanisms, Clinical Risks, and Management Considerations’
https://assets.cureus.com/uploads/review_article/pdf/495110/20260724-899175-cd3191.pdf
🍃 The Plant & its Products 🍃
🌱 Growing 🌱
For CBDA-dominant cannabis, on using hyperspectral imaging to chart levels across maturation stages
‘Integrating trichome traits, CBDA accumulation, and hyperspectral signatures for harvest-stage assessment in CBDA-dominant medicinal cannabis’
https://www.sciencedirect.com/science/article/pii/S0926669026013415
On creating a semi-dwarf cannabis for improved harvest index & cannabinoid levels using modulation of gibberellin
‘Manipulating the Gibberellin Pathway Alters Harvest Index and Cannabinoid Content in Cannabis sativa L.’
https://doi.org/10.1093/pcp/pcag104
On inducing callus (undifferentiated plant cells) production from anthers (male reproductive organ) for producing haploids (the usual 2 sets of chromosomes)
‘Callus Induction from Anthers of Cannabis sativa’
https://journals.ashs.org/view/journals/hortsci/61/8/article-p1824.xml
For the micropropagation of cannabis, a review of the recent technology advances
‘Optimizing Cannabis sativa L. micropropagation through culture medium design: a comprehensive review’
https://link.springer.com/article/10.1007/s11240-026-03545-5
For cannabis under heat stress, an analysis of its biochemical & genetic transcription response
‘Biochemical responses and endpoint RNA-seq level profiling of Cannabis sativa L. cv. Pink Pepper under heat stress’
https://www.sciencedirect.com/science/article/pii/S2667064X26002721
“Genes associated with heat shock proteins, protein folding, ribosome biogenesis, and protein processing were strongly upregulated, whereas pathways related to photosynthesis, carbohydrate metabolism, and cannabinoid biosynthesis were downregulated.”
In Thailand, the first report of root rot caused by Neocosmospora parceramosa (a soil-borne pathogen)
‘First Report of Neocosmospora parceramosa Causing Root Rot on Cannabis sativa (Industrial Hemp) in Thailand’
https://apsjournals.apsnet.org/doi/pdf/10.1094/PDIS-05-26-0919-PDN
In cannabis grown in heavy metals, the roots accumulated the highest levels with the flowers having moderate levels of exposure
‘Heavy metals in cannabis: plant contamination and effects on cannabinoid production’
https://link.springer.com/article/10.1186/s42238-026-00460-6
In hemp grown with copper stress, the combination of biochar & potassium enhanced antioxidant defenses immobilized copper in the soil & increased tolerance
‘Interactive Effect of Biochar and Potassium Enhances Copper Stress Tolerance in Hemp: Modulation of Antioxidant Defense and Mineral Homeostasis in Contaminated Mine Soils’
https://onlinelibrary.wiley.com/doi/abs/10.1002/ldr.70755
For flowering time, a genetic analysis found several genes linked to the molecular basis of flowering time
‘Identification of a major QTL and candidate gene for flowering time in industrial hemp via BSA-seq and fine mapping’
https://www.nature.com/articles/s41598-026-62855-y_reference.pdf
⚙️ Extracting, Analyzing & Formulating ⚙️
In CBD-infused water beverages, an analysis of storage properties found that CBD levels declined & microbial count increased
‘Preliminary Assessment of Physicochemical and Microbial Stability in CBD-Infused Water Beverages’
https://www.mdpi.com/2306-5710/12/7/83
For hemp leaf extraction using supercritical carbon dioxide, on optimizing the process
‘Supercritical carbon dioxide extraction of hemp (Cannabis sativa L.) leaves: Effects of temperature, pressure, and extraction time on bioactive compounds, antioxidant activity, and cannabidiol recovery’
https://www.sciencedirect.com/science/article/abs/pii/S294982442600385X
In pesticide analysis of cannabis oil, on methods for detecting 64 pesticides
‘Enhanced quantification of 64 pesticides in cannabis-derived oil by isotope-dilution LC-MRM-MS at regulatory decision thresholds’
https://link.springer.com/article/10.1007/s00216-026-06661-5
For quantifying cannabinoids, on using a nuclear magnetic resonance system
‘Validation of ERETIC-Based 1H-NMR for the Simultaneous Quantification of Cannabinoids in Complex Cannabis sativa Extracts’
https://pubmed.ncbi.nlm.nih.gov/42487553/
For detecting CBD, on creating a portable electrochemical sensor “based on a hybrid nanomaterial consisting of graphene oxide decorated with amino-silanized quantum dot”
‘Bayesian probabilistic model for quantifying CBD by voltammetry in screen-printed sensors’
https://www.sciencedirect.com/science/article/abs/pii/S0013468626013939
On detecting CBD with a low-cost colorimetric test
‘Development and validation of a low-cost spectrophotometric method for cannabidiol (CBD) quantification based on the Beam reaction’
https://pubmed.ncbi.nlm.nih.gov/42464381/
For protecting CBD from chemical degradation, a review of formulation methods
‘A review of emerging drug delivery strategies to protect cannabidiol from chemical degradation’
https://www.tandfonline.com/doi/abs/10.1080/03639045.2026.2707223
For enhanced CBD bioavailability, a novel phospholipid complex self-nanoemulsifying drug delivery system (CBD-PLC-SNEDDS)
‘Development and in vivo pharmacokinetic evaluation of a phospholipid complex self-nanoemulsifying drug delivery system (PLC-SNEDDS) for enhanced oral bioavailability of cannabidiol’
https://www.tandfonline.com/doi/full/10.1080/10717544.2026.2702143
An analysis of combining cobalt oxide nanoparticles with the cannabinoids
‘Interfacial Atomic Structure of Cobalt Oxide Nanoparticles Functionalized with Cannabinoid Molecules Revealed by High-Resolution Transmission Electron Microscopy’
https://academic.oup.com/mam/article/32/Supplement_1/ozag053.571/8743318
🍞 Food & Nutrition 🍞
In food products derived from cannabis, a review of safety concerns
‘Cannabis-derived food products: a global review of THC exposure, safety and forensic frameworks’
https://www.sciencedirect.com/science/article/abs/pii/S0278691526003595
In Koi fish, feeding them CBD was safe only at very low levels, with the principal harms being in the spleen & liver
‘Toxicological assessment of cannabidiol (CBD) in Koi carp (Cyprinus rubrofuscus): Dose-dependent effects on hematological profiles, serum biochemistry, and multi-organ histopathology’
https://he02.tci-thaijo.org/index.php/vis/article/view/281664
In steers being fed hemp biomass, their livers had reduced drug clearance capacity with the drug meloxicam reaching higher concentrations
‘Meloxicam and cannabinoids in plasma of steers fed 15% spent hemp biomass’
https://ir.library.oregonstate.edu/concern/datasets/6395wh734
In laying hens, hemp seed cake improved egg fatty acid profile with no impairments of laying performance
‘Integrating hemp cake in organic layer diets: a comprehensive assessment of egg quality, hen behavior, production costs, and life cycle impact’
https://www.sciencedirect.com/science/article/pii/S2666154326005211
For hemp seeds, an analysis of their fatty acid digestibility, total phenol content & antioxidant capacity
‘In vitro digestibility of fatty acids, total phenols, and antioxidant capacity from hemp seeds’
https://link.springer.com/article/10.1007/s00217-026-05224-3
On the nutritional properties of hemp protein hydrolysates combined with cornstarch
‘Exploring hemp protein hydrolysates: Functional and nutritional interactions with corn starch’
https://researcharchive.lincoln.ac.nz/items/8ca3f7a9-a6ae-4f03-ad72-de5e0368c61a
For hemp protein solubility, it was enhanced by adding formic acid
‘Collective weak interactions of formic acid with hemp protein: Mechanism and application in Pickering emulsion stabilization’
https://www.sciencedirect.com/science/article/abs/pii/S096399692601865X
🏗️ Industrial Uses & Fiber 🏗️
For hemp essential oils, a review of their distillation method, antimicrobial activity, anti-pest uses & incorporation into active packaging & coatings
‘Hemp (Cannabis sativa L.) essential oils and terpene-rich fractions for industrial applications’
https://www.sciencedirect.com/science/article/pii/S0926669026013245
For hemp underwear, on integrating fragrance for odor management (#underwear)
‘Sustainable Wellness Textiles: Fragrance-Integrated Bamboo–Hemp Underwear for Odor Management and Skin Comfort’
https://assajournal.com/index.php/36/article/view/1992
For tractor components, on composite panels reinforced with hemp & basalt fabrics
‘Sustainable hemp–basalt/epoxy composites with tobacco waste and zeolite fillers for agricultural machinery components’
https://www.sciencedirect.com/science/article/pii/S2090447926003758
For absorbing industrial dyes from water, on using hemp biowaste
‘Supplementary Information to: Comparative Study of the Sorption Mechanism of Reactive Black 5 Dye on Raw and Carbonized Sorbent Derived from Industrial Hemp Biowaste’
https://cherry.chem.bg.ac.rs/handle/123456789/7772
For biodiesel, on the increased performance from adding hemp seed biodiesel
‘Waste tyre pyrolysis oil-hemp biodiesel ternary blends with graphene oxide and thermal barrier coating: CI engine performance and machine learning prediction’
https://pubmed.ncbi.nlm.nih.gov/42463734/
On creating hemp stalk biochar using microwave carbonization
‘Efficient microwave synthesis of biochar from industrial hemp stalk for room-temperature ppb-level NO2 sensors’
https://www.sciencedirect.com/science/article/pii/S0926669026013658
On creating a plastic from polycannabidiol terephthalate (pCBDT)
‘Mechano‐Optical Behavior During Processing of PolyCannabidiol Terephthalate: A Biobased, High‐Tg Thermoplastic’
https://4spepublications.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pen.70738
On creating hybrid nanocomposites reinforced with hemp & basalt fabric epoxy
‘Influence of silicon nitride nanoparticle reinforcement on the structure and properties of surface treated hemp/basalt reinforced hybrid epoxy composites’
https://www.nature.com/articles/s41598-026-63667-w_reference.pdf
On creating a composite using epoxy from rice bran oil reinforced with hemp fiber
‘Development of Hemp Fibre-Reinforced Interpenetrating Polymer Network (IPN)-Based Epoxy Composites Incorporating Epoxidized Rice Bran Oil’
https://link.springer.com/article/10.1007/s12221-026-01526-1
In hemp-blended denim fabrics, an analysis of air permeability & water vapor transmission
‘Air Permeability and Water Vapour Transmission in Hemp-Blended Denim Fabrics: A Comparative Study of Hemp Blend Ratio, Weft Count and Dual-Core Weft Architecture’
https://www.mdpi.com/2673-7248/6/3/89
For hemp walls in residential Moroccan construction, a life-cycle assessment compared to a conventional wall found heating needs decreased by 40% & cooling by 15% with decreased levels of carbon impact
‘Comparative Life Cycle Assessment of Hemp Walls in Residential Construction in Morocco’
https://commons.yildiz.edu.tr/cgi/viewcontent.cgi?article=1230&context=jscmt
On improving hemp fiber performance & fire-resistance with furan composites
‘Evaluation of Woven Hemp-Reinforced Polyfurfuryl Alcohol Resin Composites for High-Performance Natural Fibre Composite Applications’
https://www.mdpi.com/2504-477X/10/7/372
For hempcrete, an analysis of hemp hurd treatments on strength & thermal properties
‘Impact of chemical treatments on hemp hurds and hempcrete: evaluating strength and thermal properties’
https://www.emerald.com/jmacr/article-abstract/doi/10.1680/jmacr.26.00020/1388032/Impact-of-chemical-treatments-on-hemp-hurds-and
🌿 THE CANNA-SCIENCE ARCHIVE 🌿
🏥 Public Health & Bioassays 🏥
For types of cannabis users, public health data on the demographics of medical, recreational & dual users
‘Demographic and health profiles of medicinal, recreational, and dual cannabis use: A comparative regression and tree-based analysis’
https://www.sciencedirect.com/science/article/pii/S2949916X26000198
In radiation therapists, a survey found that an educational intervention improved confidence & preparedness in discussing cannabis for therapeutic purposes
‘Empowering Radiation Therapists to Support Cancer Patients on Cannabis for Therapeutic Purposes’
https://www.sciencedirect.com/science/article/pii/S1939865426002729
For cannabis use assessment by perioperative healthcare staff, a brief educational intervention about the Cannabis Use and Behaviors Assessment Tool (CUBAT) improved knowledge scores
‘Implementing the Cannabis Use and Behaviors Assessment Tool (CUBAT) With Staff Education in Perioperative Services: A Pilot Feasibility Study’
https://www.jopan.org/article/S1089-9472(26)00177-2/abstract
In Bulgarian people with chronic pain or neurodegenerative diseases, a survey found a high willingness to use CBD if recommended by a healthcare professional
‘Attitudes toward cannabidiol use among Bulgarian patients with neurodegenerative diseases and chronic pain’
https://pharmacia.pensoft.net/article/203129/
For cannabinoids in the wastewater, on how to measure their levels & the difficulty of their efficient removal before entering environmental or drinking water
‘Cannabinoid Metabolites in the Urban Water Cycle: From Bio Transformation to Wastewater, Receiving Waters, and Monitoring’
https://www.preprints.org/frontend/manuscript/f744372481e16e308dbd95d5cb28403f/download_pub
In dead people, on a method for detecting metabolites of delta-8 & delta-9 THC in blood & urine
‘Postmortem case series of Δ8- and Δ9-tetrahydrocannabinol in blood and urine’
https://pubmed.ncbi.nlm.nih.gov/42448950/
On testing biofluids for cannabinoids, on a compact electrochemical sensor
‘Rapid cannabis detection in complex biofluids using an electrochemical microfluidic aptasensor platform’
https://doi.org/10.1039/d6sd00018e
🧒 Adolescents & Young Adults 🧒
In young adult cannabis users who have been abstinent for 2 weeks, they had brain scan differences in tasks of inhibition & face engagement but no connectivity differences
‘Positive face BOLD response and task-dependent ventral striatal functional connectivity during Go/No-go task among abstinent cannabis-using adolescents and young adults’
https://www.uwmlarsonlab.org/wp-content/uploads/132.-Sullivan-et-al-Frontiers-in-Adol-Med-2026.pdf
In Lebanese adolescents, watching disturbing war images increased the risk of PTSD & led to higher cannabis use intentions
‘Association between viewing more media war content and higher intention to use cannabis in adolescents: the indirect effect of post-traumatic stress’
https://link.springer.com/article/10.1186/s13011-026-00754-1
In young adults using cannabis or derived intoxicating cannabis products, a survey of their demographics & associated medical conditions
‘Medical Use of Cannabis and Derived Cannabis Products in a Sample of Young Adults in the United States’
https://journals.sagepub.com/doi/abs/10.1177/29767342261462492
For lessening youth cannabis use, a review of 15 trials found school-based cognitive-behavioral interventions had the most consistent reductions while motivational interviewing, family-based & digital interventions showed beneficial but variable effects
‘Evaluation of the Effectiveness of Psychosocial, Behavioral, and Educational Interventions for Youth Cannabis Use: A Systematic Review of Randomized Controlled Trials’
https://www.mdpi.com/2813-1851/5/3/18
In US youth using tobacco, cannabis vaping was associated with lower quit intentions & greater nicotine dependence
‘Cannabis vaping and tobacco quit intentions, quit attempts, and symptoms of nicotine dependence among youth in the United States’
https://www.sciencedirect.com/science/article/abs/pii/S0376871626002498
🧠 The Brain & Neurological Disorders 🧠
In people with ALS, an analysis of alterations to their endocannabinoid circuits as well as serotonin, opioid, GABA (the brain’s most common inhibitory neurotransmitter) & glutamate (the brain’s most common excitatory neurotransmitter)
‘Neurotransmitter-Defined Degeneration Patterns in Sporadic and C9orf72-Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems-Implications for Therapy Development’
https://pubmed.ncbi.nlm.nih.gov/42479906/
In Parkinson’s disease, computer modeling found the rare cannabinoid CBL to bind to the target monoamine oxidase B (MAO-B)
‘Exploring the Therapeutic Potential of Cannabis Constituents in Parkinson’s Disease: Insights from Molecular Docking Studies’
https://www.biorxiv.org/content/10.1101/2023.11.11.566677v1.full
For multiple sclerosis, a computer analysis suggested berberine & curcumin because of their ability to target the CB1 receptor
‘Targeting cannabinoid receptor 1 for multiple sclerosis: molecular docking and dynamic insights of berberine and curcumin as potential therapeutic agents’
https://pmc.ncbi.nlm.nih.gov/articles/PMC13389480/
In astrocytes (the brain’s most common support cell), the endocannabinoid anandamide altered the expression of microRNAs (regulators of genetic transcription) related to neuroinflammation & senescence
‘Antagonistic Activity of Anandamide on Tat-treated Human Astrocytes Identifies Inflammaging Pathways: Anandamide Affects Aging Pathways’
https://kneopen.com/JOVR/article/view/17666/32080/
In the microglia (guardian immune cells of the brain), on the activities of the CB2 receptor for regulating neuroinflammation & central nervous system homeostasis
‘Pharmacological Characterization of Cannabinoid CB2 Receptor Ligands in an In Vitro Model of Resting Microglia’
https://www.preprints.org/frontend/manuscript/6f18d9571d2b99201032534b65bdd785/download_pub
In microglia (guardian immune cells of the brain), the CB2 receptor/adenosine receptor heteromers (joined receptor complexes) modulated neuroinflammation
‘Quantifying Heteromer Partitioning Reveals Inflammation-Dependent Redistribution of Microglial Adenosine A₂A and Cannabinoid CB₂ Receptors’
https://www.ovid.com/journals/glia/fulltext/10.1002/glia.70200~quantifying-heteromer-partitioning-reveals
For NADA (an activator of the CB1 & TRPV1 receptor & the dopamine version of arachidonic acid, the building block of anandamide), the enzyme tyrosinase broke it down
‘Tyrosinase-Mediated Oxidation of Endocannabinoid and Endovanilloid N-Arachidonoyl Dopamine and N-Arachidonoyl Tyrosine’
https://www.mdpi.com/2218-273X/16/7/1040
For the orphan receptor GPR3 (which regulates both beta-amyloid plaque deposits in the brain & the metabolism of brown fat), its pharmacological chaperone molecule may be the paracannabinoid oleoylethanolamide
‘Panoramic Characterization of Proposed Ligands for GPR3: Oleoylethanolamide (OEA) as a Pharmacological Chaperone’
https://www.sciencedirect.com/science/article/abs/pii/S0026895X26000465
💭 Mental Health, Addiction & Cannabis Use Disorder 💭
For cannabis use disorder in the US, while many people were screened for it, few received treatment
‘Characterizing the Cannabis Use Disorder Cascade of Care in the United States: Treatment Gaps and Barriers to Care’
https://psychiatryonline.org/doi/abs/10.1176/appi.ps.20260052
In people who inject drugs, those with lower hardship saw their cannabis use associated with slightly lower withdrawal while those with higher hardship saw their cannabis use associated with more withdrawal
‘Material hardship moderates the association between cannabis use frequency and opioid withdrawal frequency among people who inject drugs’
https://www.sciencedirect.com/science/article/abs/pii/S0376871626002656
In young adults with PTSD, there was no interaction between PTSD & solitary cannabis use in predicting cannabis-related consequences
‘Posttraumatic stress disorder (PTSD) symptoms, solitary alcohol and cannabis use, and consequences among young adults’
https://psycnet.apa.org/record/2028-02446-001
In people co-using tobacco & cannabis, abstinence from tobacco caused an increased level of anandamide while using only cannabis decreased anandamide levels
‘Changes of peripheral endocannabinoids in individuals with chronic cannabis-tobacco co-use during cannabis ad libitum use and abstinence’
https://www.sciencedirect.com/science/article/pii/S0376871626002589
In a mouse model of depression, the ability of esketamine to reverse depressive-like behaviors depended on CB1 receptors in the hippocampus (a memory center of the brain) & their mitochondria (powerhouse of the cell)
‘CB1R-dependent mitochondrial biogenesis may contribute to the antidepressant effects of esketamine in a chronic variable stress male mouse model’
https://www.sciencedirect.com/science/article/abs/pii/S0306452226005038
🧬 Reproduction & Hormones 🧬
In women receiving hydrocortisone (to mimic the natural rising cortisol levels during pregnancy), this did not change how fast THC cleared their body but did increase the length of clearance time for the THC metabolite 11-nor-9-carboxy-THC while increasing the exposure to the THC metabolite 11-nor-9-carboxy-THC-glucuronide
‘Increased cortisol exposure alters 11-COOH-THC disposition without affecting THC pharmacokinetics in premenopausal, healthy women’
https://europepmc.org/article/ppr/ppr1206798
On cannabis use during pregnancy & early parenting, interviews found participants weighed known benefits of cannabis against uncertain risks to unborn or young children
‘Perceptions and behaviours surrounding cannabis use during pregnancy, breastfeeding, and early parenting in Canada: a qualitative study’
https://link.springer.com/article/10.1186/s42238-026-00469-x
For prenatal cannabinoid usage, this commentary examined the limited data & advised individualized clinical interpretation
‘Medical Cannabis During Pregnancy and Breastfeeding: Is the Concern Fully Evidence-Based?’
https://www.mdpi.com/2227-9059/14/8/1703
For preconception cannabis use by insured pregnant people in California, smoking was the most common mode of ingestion & cannabis use was highest in cities
‘Urban-rural and racial/ethnic disparities in modes of preconception cannabis use among insured patients receiving prenatal care at an integrated healthcare system in Northern California from 2020 to 2023’
https://www.sciencedirect.com/science/article/pii/S0376871626002620
🦠 The Immune System & Microbial 🦠
In people inhaling cannabis, they had increases in both pro- & anti-inflammatory cytokines, but not insulin sensitivity
‘Inhaling high THC cannabis acutely increases inflammation but not insulin sensitivity: a quasi-randomized trial’
https://www.nature.com/articles/s41598-026-62837-0_reference.pdf
In people using cannabis versus synthetic cannabinoids, an analysis of the differences in their immune cell levels
‘Biochemical and haematological changes in synthetic cannabinoids and marijuana users; a retrospective evaluation’
https://www.scielo.br/j/bjps/a/LtpsdcQkmQFtTw3jCbmC66x/
In both skin stem cells & hairless mice, a silicone polymer-based topical CBD reduced pro-inflammatory cytokine production via STAT3/c-Jun signaling
‘Cannabidiol Attenuates UVB-Induced Skin Inflammation via STAT3/c-Jun Suppression and Silicone Polymer—Based Topical Delivery’
https://academic.oup.com/jimmunol/article/215/Supplement_1/vkag141.1792/8744636
For the Thai formula Ya Kae Rok Bit (which contains cannabinoids), an analysis of its antioxidant & antibacterial activity as well as the effects of different solvents
‘Phytochemical profile, antioxidant potential, and antibacterial activity of Thai polyherbal formulation, a Ya Kae Rok Bit remedy’
https://www.smujo.id/biodiv/article/view/25472
For Moroccan cannabis seeds, an analysis of their components, antioxidant capacity & antimicrobial effects
‘Terroir-driven phenolic chemotypes and antioxidant/antimicrobial activities of Beldia (Cannabis sativa L.) seed extracts’
https://link.springer.com/article/10.1186/s42238-026-00468-y
🦴 Pain, Musculoskeletal & Surgeries 🦴
In people using prescription pain relievers, they had higher odds of co-using medical cannabis
‘Associations Between Medical Cannabis Use and Prescription Pain Reliever Use in U.S. Adults, 2022–2023’
https://www.tandfonline.com/doi/abs/10.1080/10826084.2026.2703195
In young adults, low-intensity exercise significantly reduced their negative affect & this might be correlated to their blood levels of the endocannabinoid anandamide
‘Low-intensity exercise reduces negative affect via circulating endocannabinoid dynamics in healthy young adults’
https://link.springer.com/article/10.1007/s00421-026-06364-w
In mouse models of pain, those without morphine receptors & those without CB2 receptors had distinct alterations in their behavior & neuroimmune profile
‘Distinct contributions of mu opioid and CB2 cannabinoid receptors to neuroimmune and behavioral responses’
https://www.frontierspartnerships.org/journals/advances-in-drug-and-alcohol-research/articles/10.3389/adar.2026.16646/full
In a mouse model of pain, the painkilling effects of acting on the CB1 receptor may be by indirect inhibition of the ATF3/NPY signaling cascade
‘The cannabinoid receptor 1 suppresses neuropeptide Y transcription in the peripheral nervous system to mediate analgesia’
https://www.sciencedirect.com/science/article/pii/S0021925826022222
In a rat model of knee osteoarthritis, the males had changes to the endocannabinoid system in their amygdala (an emotional processing center) while the females did not
‘Sex-specific differences in nociceptive behaviour and the amygdala endocannabinoid system in the rat monoiodoacetate-induced knee osteoarthritis model’
https://www.sciencedirect.com/science/article/pii/S2452073X26000206
In a male mouse model of inflammatory pain, drugs that acted as allosteric activators of the CB1 receptor (which made other drugs bind more strongly) reduced mechanical hypersensitivity without the motor impairments, memory deficits & respiratory depression of a drug that simply activates the CB1 receptor
‘Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression’
https://pubmed.ncbi.nlm.nih.gov/42492483/
For dimers between an opioid receptor & a CB1 receptor, a microscope analysis & experimental approach for investigating how they join
‘Raw experimental Data on a Combined Computational and Experimental Approach for Investigating µ-opioid - Cannabinoid CB1 Receptor Heterodimerization’
https://amsacta.unibo.it/id/eprint/8974/
❤️ The Heart & Blood ❤️
In human cardiomyocytes (heart muscle cells), cannabis extract did not alter cell morphology but did increase proliferation & the expression of cardiac genes
‘The Impact of Marijuana (Cannabis sativa) on Viability and Expression of Cardiac Markers in Human Cardiomyocytes’
https://pmc.ncbi.nlm.nih.gov/articles/PMC13389378/
🍽️ The Guts, Nutrition & the Microbiome 🍽️
In people in the ER for cannabinoid hyperemesis syndrome, they had no significant differences in their blood levels of THC, its metabolites or other cannabinoids versus people there for acute cannabis intoxication
‘Serum cannabinoid profiles of emergency department patients presenting with cannabinoid hyperemesis syndrome and acute cannabis intoxication’
https://www.tandfonline.com/doi/abs/10.1080/15563650.2026.2703873
🖐️ The Skin & Topicals 🖐️
From Korean hemp in the hemp regulation-free zone, a rat toxicity & rabbit eye test of topical CBD found it to be a slight irritant but with good skin absorption
‘Evaluation of local and acute toxicity, and skin absorption of cannabidiol isolated from Cannabis sativa cultivated in Korea’
https://link.springer.com/article/10.1007/s43188-026-00379-3
In a mouse model of prurigo nodularis (a severe chronic itch & inflammation), a topical CB1 drug decreased inflammation & itch, while knockout mice with no CB1 receptors had worse inflammation & itch
‘Novel cannabinoid agonist for treatment of prurigo nodularis and itch’
https://www.jidonline.org/article/S0022-202X(26)02333-X/fulltext
🎗️ Cancer & Chemotherapy 🎗️
For colorectal cancer, a computer analysis analyzing cannabinoid derivatives for anti-proliferative activity
‘Cannabis as a source of novel therapeutics: A computational study combining LBDD and structure-based docking/dynamics to identify novel drug-like compounds for colorectal cancer’
https://www.sciencedirect.com/science/article/pii/S1687157X26001071
In prostate cancer cells, activating the CB2 receptor reduced cell viability, colony formation & altered genes related to the cell cycle & apoptosis (programmed cellular suicide)
‘Selective CB2 Agonist JWH-133 Suppresses Viability and Migration-Related Responses in Prostate Cancer Cells’
https://www.mdpi.com/1424-8247/19/7/1114
In people with colorectal cancer, higher levels of the endocannabinoid 2-AG in their blood was associated with lower levels of neuroinvasion & metastasis to the lymphatic nodes
‘Serum metabolomics modelling reveals stage-associated purine and endocannabinoid metabolic signatures in colorectal cancer progression’
https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1900337/full
In a rat model of glioblastoma (the most aggressive brain cancer), a CBD nanoliposome downregulated inflammatory cytokines, raised antioxidant capacity, improved tumor histology & increased apoptosis (programmed cellular suicide)
‘Synthesis and characterization of Cannabidiol-loaded nanoliposomes and evaluation of their antitumor, antioxidant, and anti-inflammatory effects in a rat model of glioblastoma multiforme’
https://ajp.mums.ac.ir/article_28133.html
💊 Synthetic Cannabinoids & Hemp-Derived Cannabinoids 💊
For the synthetic cannabinoid HHC, on how the inhaled & oral ingestion routes move through the body
‘Preliminary pharmacokinetic investigations of hydroxylated metabolites after controlled inhalative and oral consumption of hexahydrocannabinol (HHC)’
https://www.nature.com/articles/s41598-026-62767-x
For detecting novel synthetic cannabinoids, a review of recent advances in analytical detection
‘Advances in the Analytical Detection and Metabolic Profiling of Emerging Synthetic Cannabinoids in Herbal Incense Products’
https://www.researchgate.net/publication/410043506_Advances_in_the_Analytical_Detection_and_Metabolic_Profiling_of_Emerging_Synthetic_Cannabinoids_in_Herbal_Incense_Products
For detecting novel synthetic cannabinoids in commercial incense, a review of the principal analytic techniques
‘Regulatory Challenges and Forensic Identification of Novel Synthetic Cannabinoids in Commercial Herbal Incense Markets: A Global Perspective’
https://www.researchgate.net/publication/410046814_Regulatory_Challenges_and_Forensic_Identification_of_Novel_Synthetic_Cannabinoids_in_Commercial_Herbal_Incense_Markets_A_Global_Perspective
For synthetic cannabinoids, a study in rats on how their structures alter their metabolism
‘How structural variations in synthetic cannabinoids affect their metabolism: A pilot study on the in vivo metabolism of 8 synthetic cannabinoid receptor agonists’
https://link.springer.com/article/10.1007/s00204-026-04517-6
“AMB-FUBINACA, ADB-FUBINACA, SDB-005, APINACA, CUMYL-4CN-BINACA, 5 F-AMB-PINACA, 5 F-AB-PINACA, and THJ-2201”
🔬 Biochemical Discoveries & Research Tools 🔬
On pathways for turning CBD into various THC isomers
‘Regioselective acid-catalyzed conversion of cannabidiol into THC isomers: experimental and computational elucidation’
https://pubmed.ncbi.nlm.nih.gov/42475118/
For synthesizing CBD & related cannabinoids, on a novel FeCl3·6H2O-catalyzed reaction that can select for stereoisomers
‘Unveiling the Origin of Regioselectivity in Iron(III)-Promoted Friedel–Crafts Synthesis of Cannabinoids: Theoretical Studies and Synthetic Applications’
https://pubs.acs.org/joceah/article/doi/10.1021/acs.joc.6c01142/5231253/Unveiling-the-Origin-of-Regioselectivity-in-Iron
On creating co-crystals of CBD, CBN & CBG by improving thermostability with 4,4’-bipyridine
‘Structure–stability relationships of pure cannabinoids and their cocrystals under forced degradation conditions’
https://link.springer.com/article/10.1186/s42238-026-00474-0
For comparing how CB1 drugs bind to & activate the receptor, this investigation found that the affinity measurements were largely comparable across assay conditions while the potency estimates were more context-dependent
‘Do assay parameters affect the inter-assay comparability of cannabinoid CB₁ receptor affinity and activation measurements?’
https://www.sciencedirect.com/science/article/pii/S0041008X26002413
Thanks.
- lex
PS: For this week’s great jazz singer, Sheila Jordan on her 1963 ‘Portrait of Sheila’. Although she had been singing & playing piano since the age of 11 while enduring the poverty & alcoholism of her young home, rising to be the first vocalist to ever release an album on the storied Blue Note label in 1962, Sheila Jordan still spent much of the ‘60s & ‘70s working a conventional day job as a legal secretary. Even in the ‘40s & ‘50s, she impressed Charlie Parker with the lyrics she wrote for his songs & studied music theory with the Charles Mingus compatriot Lennie Tristano (though she kept getting arrested for being a white girl in Detroit who wanted to hang around Black musicians & Black clubs). She eventually married Charlie Parker’s bandmate, the pianist Duke Jordan, but his heroin addiction contributed to their divorce. The daughter that came out of the relationship led to her raising her child in the church & singing there instead for the good steady paycheck. But by the 1980s, her talents at improvising lyrics, scatting & the emotional delivery of ballads led to her full-time work as a songwriter & singer in bebop & free jazz. She was honored with the NEA Jazz Masters Award & soon after, a biography was published, ‘Jazz Child: A Portrait of Sheila Jordan’, where she talked about her own struggles with addiction. On the stage until the age of 95, Sheila Jordan passed away just last year at the age of 96.
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