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C&P#48: Cannabis for tinnitus, diabetes & PTSD + CBD for bones, addiction, psychosis & cancer
UN backwards + Germany forwards + Afghanistan downwards
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Welcome to the 48th edition of Cannabinoids & the People. This newsletter collects all the new cannabinoid science each week. You can check out last week’s issue here & if you haven’t subscribed yet, please do.
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Cannabis for tinnitus. diabetes & treatment-resistant PTSD
CBD for bone disease, addiction, psychosis & cancer
On HIV & CBD’s ability to lower inflammation
The downsides of vaping
We get meta on scraping social media posts for cannabis
For surgery, 3 studies where being a cannabis user improved your outcomes (or at least didn’t hurt)
For young people, case studies of potential cardiovascular problems from cannabis smoking
For your bladder, AEA & 2-AG as the Yin & the Yang
Hermaphroditic cannabis yields more cannabinoids
Speed dating for hemp (breeding)
Enjoy this free offering from my company White Whale Creations.
I produce educational content for cannabis & psychedelic companies: writing, science archives, social media content, newsletters & podcasts.
My weekly EU report on Weed Talk News from Pro Cannabis Media:
Cannabis censorship in the Czech Republic + Portugal moves hemp’s THC limit from 0.2% to … 0.3% THC
My work & platforms: Linktree
YouTube for educational videos, lectures & daily shorts on new cannabinoid science
My podcasts (seeking a sponsor for the next season of ‘The Lex Files’)
Anandamide; or, the People: my graphic novel series on cannabis, the endocannabinoid system & the War on Drugs based on Moby-Dick
LinkedIn, Twitter & my TikTok on books, hermeticism, science & history
Sponsor: PlusCBD & a commitment to education & research
One sign of a great CBD company is when they go to the next level for educating their customers. PlusCBD has articles for all levels of knowledge, videos about how CBD works & a YouTube channel of great educational content.
(Plus, they even sponsored two seasons of my podcast ‘The Lex Files’)
In addition, they’ve done more peer-reviewed research than any other company other there. They put their money down to advance the field.
Check out this (partial) bibliography:
· A GRAS (Generally Recognized as Safe) study on hemp extracts to prove their safety
· A clinical trial on healthy people to show that hemp extracts helped their cholesterol, sleep quality, stress response & perceived life pleasure
· A post-marketing safety study where experts went over 2 years of PlusCBD’s adverse event reports to find the high safety levels
· A case series of using CBD to treat PTSD
· And funding me to create the extensive cannabinoid science archive at CVResearch.info
PlusCBD takes their commitment to education & research to the next level. And they do the same with their products.
Buy excellent CBD products today from PlusCBDoil.com.
Best Of Cannabinoid Science...
Our friend Dr. Amanda Reiman is first author on this paper about public health paternalism & medical cannabis
Medical cannabis identity and public health paternalism
Right on Dr. R! How different states have different laws for what diseases are worthy of medical cannabis is as infuriating as it is harmful.
Anyway, sign up for her newsletter at MyPersonalPlants.com.
In a survey of tinnitus patients, the ones using cannabis reported it helped with their dizziness, anxiety, bodily pain & sleep disturbances
Cannabis use amongst tinnitus patients: consumption patterns and attitudes
For 14 combat veterans with treatment-resistant PTSD, medical cannabis improved total sleep scores, sleep quality, sleep duration as well as PTSD symptom scores for intrusiveness, avoidance & alertness
Medical cannabis for treatment-resistant combat PTSD
In patients with type 2 diabetes, 8 weeks of a 10:1 CBD:THC spray helped with their cholesterol, triglyceride & insulin levels
A Phase I Randomized, Double-blind, Placebo-controlled Study on Efficacy and Safety Profile of a Sublingually Administered Cannabidiol /Delta 9-tetrahydrocannabidiol (10: 1) Regimen in Diabetes Type 2 Patients
In people with a high risk for psychosis, brain scans show that CBD helped to normalize alterations in the blood flow of their hippocampus (memory center of the brain)
Acute Effects of Cannabidiol on Hippocampal Blood Flow in People at Clinical High Risk for Psychosis
Black sexual minority individuals more often use cannabis for “social, coping, enhancement, and expansion motives than straight participants”
Sexual orientation and cannabis outcomes among Black Individuals: The role of cannabis use motives
Cannabis & alcohol linked to a greater number of sexual partners - which is bad for monkeypox but good for your body count
Sexual behaviors, cannabis, alcohol and monkeypox infection
I've never seen this before: an analysis of cannabis use in sub-Saharan Africa
Cannabis use in sub-Saharan Africa: A systematic review and meta-analysis
After reviewing 53 studies, they concluded “life-time cannabis use prevalence in sub-Saharan Africa appears to be approximately 12% for adults and just under 8% for adolescents.”
A review of using cannabinoids for bone diseases like osteoporosis & their associated inflammation like osteoarthritis
Cannabinoids: new friends in bone fracture and in joint disease prevention?
For substance use disorder, a review of 29 studies finds CBD to be the most promising for treating multiple substance use disorders
Evidence from Human Studies for Utilising Cannabinoids for the Treatment of Substance-Use Disorders: A Scoping Review with a Systematic Approach
For cancer, a review of CBD's ability to lower inflammation, regulate autophagy (cellular recycling) & increase tumor apoptosis (cellular suicide)
Cannabidiol regulates apoptosis and autophagy in inflammation and cancer: A review
And a new mechanism found of how CBD kills ovarian cancer
A novel mechanism of cannabidiol in suppressing ovarian cancer through LAIR-1 mediated mitochondrial dysfunction and apoptosis
I am very excited for my graphic novel chapter on the cannabinoids and cancer. It will look like a Mission Impossible team of commando cannabinoid elephants getting inside those cancer cells & laying detonation charges & other sneaky Black Hat tactics to destroy those monsters of metastasis.
From UMiss, an analysis of the impurities found in delta-8 THC products
Isolation and Characterization of Impurities in Commercially Marketed Δ8-THC Products
In a songbird model of developmental delays via brain trauma, CBD improved their singing ability & reduced inflammation & oxidative stress in the brain
Cannabidiol Inhibits Neuroinflammatory Responses and Circuit-Associated Synaptic Loss Following Damage to a Songbird Vocal Pre-motor Cortical-Like Region
Because the ability of a bird to learn to sing is so similar to how humans acquire language, they are often used as a model of higher-level development.
An atomic analysis of how you bind the CB1 receptor
All-Atom Molecular Dynamics Simulations Indicated the Involvement of a Conserved Polar Signaling Channel in the Activation Mechanism of the Type I Cannabinoid Receptor
An evergreen note on reading restricted paper:
First stop for seeing if there’s a free version of a paper, use the Google Scholar Chrome extension (Mac version), Google Scholar itself or try ResearchGate.
3 other helpful browser extensions are: Unpaywall, Open Access Button & PaperPanda
For the infamous backdoor, use Sci-Hub – the pirated papers repository (Chrome extension here). This works better for older paper than the stuff that just came out.
For Twitter users, send a Tweet of the paper’s title with the hashtag #icanhazpdf. It works because people are beautiful(ish).
Finally, email the author. They’re almost always happy to oblige because, thanks to the predatory academic publishing system, they don’t make a dollar off of their papers.
the Headlines & Fav Articles
On Weed Talk News, my tribute to Dr. Mechoulam…
And tributes by others
But most of all, read Dr. Mechoulam’s final paper summarizing his life of research…
A Delightful Trip Along the Pathway of Cannabinoid and Endocannabinoid Chemistry and Pharmacology
UN Suggests U.S. Federal Government Must Force States To Repeal Marijuana Legalization To Comply With International Treaty
Germany got ‘good feedback’ from the EU about their cannabis plans & will continue moving forward
Biden’s budget continues to block DC from determining its own approach to cannabis
I cannot imagine the hell it must be for your city to be overseen by the federal government.
Veterans advocate groups criticize the US Veterans Affairs for dragging their feet on cannabis
Why New York’s cannabis equity program is stranding women entrepreneurs by Mona Zhang
New Jersey reports that cannabis companies were the 9th biggest lobbyists
According to Nielsen, what factors influence consumers buying hemp products
What factors make consumers in the USA buy hemp products? Evidence from Nielsen consumer panel data
In UK airports over the last 2 months, 26 young Americans caught with suitcases stuffed with California weed by Max Daly
‘Islamic Emirate of Afghanistan’ bans hemp production
The War on Drugs & Prohibition
From that stalwart hero of drug policy research Beau Kilmer, a 600 page report on ‘America’s Opioid Ecosystem’ & what we can be doing better
Psychedelics, Plant Medicines & Other Psychoactives
[This isn’t a deep dive into all of the science of psychedelics & other psychoactives like I do for the cannabinoids. If a newsletter with all that new science would be of interest to your company or organization, reach out to me]
Oregon graduates its first psilocybin mushroom therapists
Another post-mortem on the collapse of the psychedelic training program Synthesis, a well-written piece by someone who knew many of the players
On the infamous NBOMe psychedelic series by Andrew Gallimore
Nutmeg: The Psychedelic Spice With A Dark Side
The Plant & the History
Growing & Farming
A speed dating protocol for hemp
Need for speed: a breakthrough speed breeding protocol for hemp
An analysis of photoperiods for medical cannabis biomass yield
Moving Away from 12:12; the Effect of Different Photoperiods on Biomass Yield and Cannabinoids in Medicinal Cannabis
A look at monoecious cannabis (male & female sexual organs on the same plant, which is rare in cannabis) & how they tend to have higher cannabinoid yields
Monoecious Cannabis sativa L. discloses the organ-specific variation in glandular trichomes, cannabinoids content and antioxidant potential
Using reishi mushrooms as a pretreatment for hemp flowers
Changes in polyphenols composition and antioxidative properties of hemp (Cannabis sativa L.) inflorescences pretreated by Ganoderma lucidum
I've never seen anything like this one before so if any of you growers out there know about it, clue me in.
A deep analysis of hemp when it’s undergoing stress from high salt levels in the soil
Comprehensive Transcriptome and Metabolome Analysis of Hemp (Cannabis Sativa L.) in Soil Under NaCl Stress
CBD acts as a natural insecticide to fall armyworms
Cannabidiol reduces fall armyworm (Spodoptera frugiperda) growth by reducing consumption and altering detoxification and nutritional enzyme activity in a dose-dependent manner
One of the great mysteries is why the plant produces these expensive cannabinoids. One of the leading theories is that they are a tool in the neverending war against hungry insects.
In sustainable agriculture, on using leftover hemp stocks to create aerogels for the slow release of fertilizers
Waste hemp-stalk derived nutrient encapsulated aerogels for slow release of fertilizers: A step towards sustainable agriculture
In Washington state, first report of a viroid from hops infecting hemp
First reports of Beet curly top virus, Citrus yellow vein-associated virus, and Hop latent viroid in industrial hemp (Cannabis sativa) in Washington State
On growing cannabis around the old mines of Christmas Island
Physiological and cannabinoid responses of hemp (Cannabis sativa L.) to rock phosphate dust under tropical conditions
Hemp as a food
An analysis of hempseed oil
Biochemical characteristics of the hemp (Cannabis sativa) seed oil
And an analysis of hempseed flour
Assessment of chemical composition of hemp (Cannabis sativa) seed flour
Enrich your camel yogurt with hemp seeds!
Enrichment of camel yogurt using hemp seeds as a rich source of omega 3 and physicochemical evaluation
Veterinarian Uses & Animal Feed
In canine epilepsy, an analysis of the changes to the CB1 receptors in the hippocampus (memory center of the brain)
Hippocampal expression of the cannabinoid receptor type 1 in canine epilepsy
Feeding hemp seeds to goats increased the availability of good plant chemicals in their meat
Bioavailability of bioactive phytochemicals in selected tissues and excreta from goats fed hempseed cake (Cannabis sativa L.) finisher diets
In hens, hemp seed improved the lipid profile of their eggs
Assessment of Fatty Acids Profile and Oxidative Stability of Eggs from Laying Hens Fed Diets Containing Hemp Seed or Hempseed Cake
Look, another paper analyzing the tweets about cannabis (when one talks about an addiction to cannabis, one should include researchers being addicted to scraping social media content about cannabis)
What is the hype on #MedicinalCannabis in the United States? A content analysis of medicinal cannabis tweets
Oh, and how meta can we get? A review of 42 studies on analyzing cannabis social media posts
Using Social Media Data to Investigate Public Perceptions of Cannabis as a Medicine: Narrative Review
A review of cannabinoid history & the methods for detecting them
A Review on the Impact of Cannabis in Society and the Analytical Methodologies for Cannabinoids
Clinical Studies & Surveys
In patients with sleep apnea, a combination of dronabinol (synthetic THC) & the common treatment atomoxetine reduced symptom severity & led to subjective improvements
The combination of atomoxetine and dronabinol for the treatment of obstructive sleep apnea: a dose escalating, open-label trial
An analysis of the UK Medical Cannabis Registry finds that cannabis-based medicines are associated with improvements in the quality of life of people with chronic diseases
An observational study of safety and clinical outcome measures across patient groups in the United Kingdom Medical Cannabis Registry
While a conservative French review of therapeutic cannabis is worried about CBD drug interactions & warns that THC has a higher proportion of serious adverse events
Place of therapeutic cannabis in France and safety data: A literature review
Les français ont toujours 5 ans de retard. Mais ils font de si bons fromages...
Testing a nano THC nasal spray & its ability to penetrate the brain & body
Measurement of Δ9THC and metabolites in the brain and peripheral tissues after intranasal instillation of a nanoformulation
Adolescents & Vaping
In teens, the vaping of THC or nicotine associated with depression & anxiety
Symptoms of Depression and Anxiety and Subsequent Use of Nicotine and THC in Electronic Cigarettes
In a mouse model of vaping, the vaping of CBD caused greater inflammation, lung damage & higher oxidative stress than nicotine vaping
Not all vaping is the same: differential pulmonary effects of vaping cannabidiol versus nicotine
In young adults, alcohol & cannabis use associated with next-day absenteeism at school & work
Alcohol and marijuana use predicting next-day absenteeism and engagement at school and work: A daily study of young adults
In male rats, the effects of vaping CBD and/or delta-8 THC
Behavioral Effects of Vaporized Delta-8 Tetrahydrocannabinol, Cannabidiol, and Mixtures in Male Rats
Mental Health & Addiction
On the use of CBD for panic disorder
Cannabidiol, NegEnt and Panic Disorder
In cannabis users, the genders have different responses to acute stress in the response of their neuroendocrine system
Sex Differences in Neuroendocrine, Sympathetic Nervous System, and Affect Responses to Acute Stress in Cannabis Users
In a five year longitudinal study of people with psychotic disorders, discontinuing cannabis use lowered their odds of having hallucinations & improved their level of functioning
Discontinuing cannabis use: Symptomatic and functional outcomes in people with an established psychotic disorder
In people with schizophrenia & cannabis use disorder, being dependent on tobacco doubled the severity of their cannabis withdrawal
Does tobacco dependence worsen cannabis withdrawal in people with and without schizophrenia-spectrum disorders?
In a survey of autism caregivers, most were not familiar with using cannabis for autism but the majority were willing to try it
Caregivers' views on cannabis use for their children with autism
In mice, cannabinoids altered the connectivity in the brain & impaired decision making
Exogenous Cannabinoids Impair Effort-Related Decision-Making via Affecting Neural Synchronization between the Anterior Cingulate Cortex and Nucleus Accumbens
In a mouse model of cocaine addiction, the CB1 receptor seems to mediate the response to stress with a difference in the response by gender
Repeated footshock stress induces an escalation of cocaine self-administration in male and female rats: Role of the cannabinoid receptor 1
The Brain & its Diseases
In epilepsy patients already taking cannabis, a second type of cannabis-based therapy did not significantly improve seizure control
Second-line cannabis therapy in patients with epilepsy
In patients with Parkinson's disease, 8 weeks of a CBD-rich cannabis extract at low levels (average of 15 mg CBD & 5 mg THC per day) did not alter disease severity, function, anxiety or depression but it was safe & improved a number of protein levels
Cannabidiol-enriched cannabis extraction product in Parkinson's disease: A randomized, double-blind, and placebo-controlled trial in Buriram Hospital
I believe this study was not long enough & used levels that were too low. When you're trying to cause neurogenesis (new brain cell growth) & synaptic plasticity (new brain connections), it takes weeks or months & higher levels than they were using here. For more, see my advice on CBD & THC for neurodegenerative diseases.
How 2-AG works in the cortex of adult rats
Endocannabinoid 2-Arachidonoylglycerol Synthesis and Metabolism at Neuronal Nuclear Matrix Fractions Derived from Adult Rat Brain Cortex
The toxic pesticide chlorpyrifos seems to cause its negative neurotoxic changes via pathways other than the CB1 receptor
Cnr1-/- has minimal impact on chlorpyrifos-mediated effects in the mouse endocannabinoid system, but it does alter lipopolysaccharide-induced cytokine levels in splenocytes
Harms, Cannabis Use Disorder & Street Synthetics
An analysis of the synthetic cannabinoids smuggled into English prisons on paper
The identification of synthetic cannabinoids in English prisons
The Immune System & Pathogens
A review of HIV & the impact of cannabinoids on its inflammation
The impact of cannabinoids on inflammasome signaling in HIV-1 infection
In people living with HIV, CBD lowered inflammation via alterations to the expressions of genes in bone marrow cells
Oral CBD treatment is associated to an anti-inflammatory gene expression signature in myeloid cells of people living with HIV
In a monkey model of HIV, THC combines with antiretroviral treatment to alter the miRNA that regulate gene expression
Alterations in Abundance and Compartmentalization of miRNAs in Blood Plasma Extracellular Vesicles and Extracellular Condensates during HIV/SIV Infection and Its Modulation by Antiretroviral Therapy (ART) and Delta-9-Tetrahydrocannabinol (Δ9-THC)
CBG causes part of its antibiotic effects by disruption of bacterial communication
The Antibacterial Effect of Cannabigerol toward Streptococcus mutans Is Influenced by the Autoinducers 21-CSP and AI-2
Hormones, Reproduction & Maternal Effects
In bovine sperm, exposure to THC alters the activation of their genes & may adversely affect sperm function by causing premature capacitation (the changes that allow sperm to penetrate the egg)
Sperm capacitation and transcripts levels are altered by in vitro THC exposure
A review of the consequences of prenatal exposure to alcohol & cannabis
Combined exposure to alcohol and cannabis during development: mechanisms and outcomes
In a rat mother, exposure to nicotine during breastfeeding changes the endocannabinoid system in their female offspring but not male
Nicotine exposure during breastfeeding alters the expression of endocannabinoid system biomarkers in female but not in male offspring at adulthood
If a pregnant rat mother has an activated immune system from an infection, it will impair the endocannabinoid signaling in her adolescent male offspring’s mesolimbic system (brain center of dopamine-related goal-oriented behaviors such as reward, attention & motivation)
Maternal immune activation impairs endocannabinoid signaling in the mesolimbic system of adolescent male offspring
On CBD drug interactions in cancer patients, they made an analysis of potential interactions
Cannabidiol-drug interaction in cancer patients: A retrospective study in a real-life setting
But they didn't actually report on whether any patients experienced interactions. They just cross-referenced a database of potential interactions.
In gut cancer, how the cannabinoid system interacts with the histamine & orexin systems
Examining the Role of Histaminergic, Orexinergic, and Cannabinergic Systems in Redox Regulation in Gastric Adenocarcinoma
For bone & joint cancer, the combination of CBD & the common treatment doxorubicin caused synergistic anti-cancer effects
The synergistic anticancer effect of CBD and DOX in osteosarcoma
Guts, Metabolism, the Microbiome & Oral Health
A case report of a young person with type-1 diabetes experiencing cannabinoid hyperemesis syndrome (uncontrolled cyclical vomiting)
Cannabinoid Hyperemesis Syndrome in a 23-Year-Old Woman with Uncontrolled Type 1 Diabetes Mellitus
In a mouse model of type-1 diabetes, CBD helped with their anxiety & fearful memories
Cannabidiol modulates contextual fear memory consolidation in animals with experimentally induced type-1 diabetes mellitus
In rats anxious because of the withdrawal of food, blocking their FAAH enzyme (a function of CBD) reduced their anxiety
Anxiety associated with palatable food withdrawal is reversed by the selective FAAH inhibitor PF-3845: A regional analysis of the contribution of endocannabinoid signaling machinery
Pain, Inflammation & Surgeries
In humans taking oxycodone, inhaled THC did not alter their respiratory depression
Inhaled D9-tetrahydrocannabinol does not enhance oxycodoneinduced respiratory depression: randomised controlled trial in healthy volunteers
In patients having joint surgeries, those with cannabis use disorder had a shorter hospital stay & increased home discharges with no effect on postoperative complications
Cannabis use disorder is associated with shorter length of stay and increased home discharge after primary total joint arthroplasty: a propensity-weighted analysis
In trauma patients, those using cannabis had a slightly lower chance of developing venous thromboembolism (a blood clot in the vein)
Clotting Propensity in Trauma Patients According to Marijuana Use: A Descriptive Analysis
In patients undergoing pancreas surgery, cannabis use was not associated with an increase of postoperative complications
Cannabis use and post-operative complications in patients undergoing pancreatic resection
In middle-aged people, a 10 year study found an association between heavy lifetime cannabis use & atherosclerosis (plaque in the arteries), with a stronger effect in males
Association between cannabis use and ten-year estimated atherosclerotic cardiovascular disease risk in a middle-aged population survey
A genetic study found no link between cannabis use & the risk of coronary heart disease or stroke
Cannabis use and atherosclerotic cardiovascular disease: a Mendelian randomization study
A young person with heart troubles potentially stemming from cannabis use
Cannabis-Associated Myocardial Infarction with Non-Obstructive Coronary Arteries in a Young Patient with Underlying Myocardial Bridge
A young person with chest pain potentially from cannabis abuse
A Case Report of Cannabis Abuse: A Surprising Etiology of Elevated Troponin
The Genitourinary System
In Guinea pig bladders, a study of the effects of anandamide & 2-AG on urine storage, voiding & the physical sensations from the bladder
Endocannabinoids, anandamide and 2-AG, regulate mechanosensitivity of mucosal afferents in the Guinea pig bladder
As often happens, anandamide & 2-AG were the yin & the yang. “Our data indicated that anandamide and 2-AG have opposite effects on mechanosensitivity of mucosal capsaicin-sensitive afferents in the guinea pig bladder; mAEA potentiated while 2-AG inhibited responses of mucosal afferents to mechanical stimulation.”
In eye damage, a review of how the endocannabinoid system interacts with other systems to regulate eye function & blood pressure
A Cross Talk between the Endocannabinoid System and Different Systems Involved in the Pathogenesis of Hypertensive Retinopathy
New activators of the CB2 receptor for treating inflammatory pain
Discovery of 4-(1,2,4-Oxadiazol-5-yl)azepan-2-one Derivatives as a New Class of Cannabinoid Type 2 Receptor Agonists for the Treatment of Inflammatory Pain
New drugs to activate CB1 receptors based on triazoles
Synthesis, relative configuration and CB1 receptor affinity studies for a set of 1,2,3-triazole derivatives
PS: For this week’s single-note picking blues album, Scrapper Blackwell’s ‘Mr. Scrapper's Blues’. Part Cherokee & one of 16 children born in upstate New York, Scrapper got his nickname from his grandmother for his fiery nature. He built his first guitar out of a cigar box & taught himself to play. He was a working musician by his teens & by the mid-1920s, he became famous for his musical collaboration with the pianist Leroy Carr. By 1935, together they recorded over 100 songs before the war years cut down the music industry. He experienced a revival in the ‘50s with the beginning of the folk music revolution, but sadly, he was killed by a mugger in an Indianapolis alleyway. Now he’s known as one of the most important guitarists of the ‘20s & ‘30s.