C&P#53: CBD topicals for elite athletes + CBD for eating disorders + cannabis & your genetic variants
C&P#53: CBD topicals for elite athletes + CBD for eating disorders + cannabis & your genetic variants
James Comer gunning for the FDA
Hello everyone,
Welcome to the 53rd edition of Cannabinoids & the People, a weekly newsletter where I collect all the new cannabinoid science. You can check out last week’s issue here & if you haven’t subscribed yet, please do.
As always, here’s the Living Glossary of Cannabinoid Terms & at the bottom is the album of the week.
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A reminder...
to send in your entry for the ‘People of the Cannabinoids Connections Board’: 100 – 200 words on a connection you’re looking for in the cannabinoid space
this is your last week for entering the raffle for winning of my Queer Cannabis graphic novels. Just forward this email to someone or post about this newsletter on social media & let me know by replying to this email.
Also, I upgraded my recording studio & video software. You can see the new recording space in the first two parts of ‘The Graphic Novels I Should Be Writing Series...’ as well as in my newest One Minute Cannabinoid Science video.
This week…
CBD for eating disorders & cannabis for women’s pelvic pain
Elite athletes report topical CBD helpful for pain, sex, home life
CBD for dogs in cars!
But yes, CBD can raise liver enzyme levels
Problems with cannabis linked to impulsivity <looks around guiltily, darts away>
On how your genetics affects your cannabis experience
How cannabinoids for cancer is like a Mission Impossible movie
Lots on the complexity of seizures
Using hemp to clean soil polluted by heavy metals
Exxxxxtended state DMT
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My work this week:
My interview on the Cannabis Truth podcast: “Lex Pelger - World Traveler”
https://radiopublic.com/cannabis-truth-6079m0/s1!335b0
A lot on cannabis, but this one delves more into the supernormal in case that’s your bag.
My one-minute Cannabinoid Science:
Acupuncture & the endocannabinoid system + CBD's antidiabetic effects + For inflamed prostates: CBD & the minor cannabinoids
The Graphic Novels I Should Be Writing Series...
Chapter 1 of the Moby Dick pot books: Loomings + Chapter 2: The Messenger Bag
On TikTok:
Koestler's mystical experience in prison + Readings from Dr. Nick Herbert's 'Physics on all Fours' + Chuang Tzu's Daoist classics + Sciencemancy: the Gaia hypothesis
(I link to YouTube for accessibility, but find me on TT @lexpelgerandhisbooks)
My platforms: Linktree
YouTube for educational videos, lectures & shorts on new cannabinoid science
My podcasts
Anandamide; or, the People: my graphic novel series on cannabis, the endocannabinoid system & the War on Drugs based on Moby-Dick
LinkedIn, Twitter & my TikTok on books, hermeticism, science & historyWays to support this work:
Buy Me a Coffee
Venmo: @Lex-Pelger
Zelle: pelger@gmail.com
PayPal: donate here
Sponsor: PlusCBD & a commitment to quality
I’m proud to promote the CBD-rich hemp extracts of PlusCBD because I know from the inside about their commitment to quality.
They start with agricultural non-GMO hemp grown with no pesticides: only water, soil & sunlight.
Then they use the clean, safe method CO2 extraction to get out all of the terpenes, minor cannabinoids & fatty acids that go into a quality hemp extract.
And finally they test their products at least 3 times internally & once externally by third-party labs before it ever goes out the doors.
The result is an excellent CBD-rich hemp extract product that changes people’s lives. Check out their product selection here & buy some health today.
Best Of Cannabinoid Science...
ProjectCBD has a new site!
https://projectcbd.org/
And a neurotransmitter series by the handsomest science writer around (according to his mother).
Plus, Martin Lee on how all of the pieces of the plant can be medicinal
https://projectcbd.org/science/the-plant-the-whole-plant-nothing-but-the-plant/
Clinical
In a study of over 3500 people, they could find no way to predict the final medical doses of CBD & THC, recommending that “Clinical guidelines should maintain a highly individual approach for cannabinoid dosing”
Can we predict the treatment doses of THC and CBD and does it matter?
https://pubmed.ncbi.nlm.nih.gov/37003923/
Love this conclusion. “There’s no way to predict your dosage. Listen to yourself, figure it out.”
In 20 elite athletes, topical CBD was well tolerated & helpful in a number of domains
Topical cannabidiol is well tolerated in individuals with a history of elite physical performance and chronic lower extremity pain
https://pubmed.ncbi.nlm.nih.gov/36991501/
“The mostly commonly reported effects were skin dryness (43% of study completers) and skin rash (21% of study completers), which rapidly resolved. There was a significant improvement in self-reported pain levels … and pain-related disability, including family and home responsibilities, life support activities, occupational activities, recreational activities, self-care, sexual function, and social activities.”
In a survey of women with muscular pelvic pain, the cannabis users found it effective for relieving the pain while non-cannabis users said they’d be willing to try it
Cannabis use preferences in women with myofascial pelvic pain: A cross-sectional study
https://www.sciencedirect.com/science/article/pii/S2590161323000170
75% indicated a willingness to try vaginal or vulvar applications of cannabis products & I believe that this route of administration is one of the most underutilized & important methods of medical cannabis use out there.
In patients in remission from their first episode of schizophrenia, cannabis use increased the rate of relapse, but it's not clear whether that's a trigger or a consequence
Cannabis Use and Symptomatic Relapse in First Episode Schizophrenia: Trigger or Consequence? Data From the OPTIMISE Study
https://pubmed.ncbi.nlm.nih.gov/36999551/
In kids exposed to stress, their epigenetics change the expression of their CB1 receptors & FAAH enzymes (which break down anandamide)
Epigenetic (re)programming of gene expression changes of CB1R and FAAH in the medial prefrontal cortex in response to early life and adolescence stress exposure
https://pubmed.ncbi.nlm.nih.gov/36909279/
A variant of your gene for the CB1 receptor may be associated with lifetime cannabis use & childhood trauma increasing the risk of psychosis
Lifetime cannabis use and childhood trauma associated with CNR1 genetic variants increase the risk of psychosis: findings from the STREAM study
https://pubmed.ncbi.nlm.nih.gov/36918037/
In a Nigerian genome wide association study, cannabis smoking- but not cannabis use disorder - was associated with a certain variant of a dopamine transporter gene
Association of Dopamine Transporter Gene (DAT1) 40 bp 3' UTR VNTR Polymorphism (rs28363170) and Cannabis Use Disorder
https://pubmed.ncbi.nlm.nih.gov/37020726/
Queer kids more likely to smoke blunts (cannabis with tobacco)
Past-Year Blunt Smoking among Youth: Differences by LGBT and Non-LGBT Identity
https://pubmed.ncbi.nlm.nih.gov/37047919/
In dogs stressed out by car travel or separation, one dose of CBD significantly lowered their stress-related measures
A single dose of cannabidiol (CBD) positively influences measures of stress in dogs during separation and car travel
https://pubmed.ncbi.nlm.nih.gov/36908527/
Reviews
A meta-analysis shows that CBD has an increased probability of liver enzyme elevation
Cannabidiol-associated hepatotoxicity: A systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/36912195/
A positive review on using CBD for eating disorders
Major approaches to cannabidiol in the treatment of binge eating and obesity: a systematic review
https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/282
A strong series of case studies & research reports by neuropsychopharmacology world experts on using CBD for treating brain disorders
Editorial: Cannabidiol treatment in neurotherapeutic interventions, volume II
https://pubmed.ncbi.nlm.nih.gov/36909164/
In multiple sclerosis, a review of the evidence showing the combination of THC & CBD reduces spasticity
Use of cannabis medicine for the treatment of spasticity-associated pain
https://www.scielo.br/j/brjp/a/9syCLsBmLJF3g53GQvKMxXB/?lang=en
Plus this fMRI study of how this combination changes brain connectivity
Resting-state functional connectivity in multiple sclerosis patients receiving nabiximols for spasticity
https://pubmed.ncbi.nlm.nih.gov/36991352/
“On fMRI analysis, Sativex® [1:1 THC:CBD spray] exposure was associated with global brain connectivity increase (particularly in responders [to the treatment]), decreased connectivity of motor areas, and bidirectional connectivity changes of the left cerebellum with a number of cortical areas.”
An even-handed review on using cannabinoids in cancer treatment
Potential, Limitations and Risks of Cannabis-Derived Products in Cancer Treatment
https://pubmed.ncbi.nlm.nih.gov/37046779/
There has always been a big debate about how paracetamol lowers pain & this literature review adds more evidence pointing to the argument that paracetamol doesn't work via the COX pathways but by the production of the cannabinoid AM404, an activator of the TRPV1 receptors (a major contributor to neuronal response to pain in the brain & dorsal horn)
An Updated Review on the Metabolite (AM404)-Mediated Central Mechanism of Action of Paracetamol (Acetaminophen): Experimental Evidence and Potential Clinical Impact
https://pubmed.ncbi.nlm.nih.gov/37016715/
A solid review of where the cannabinoids are binding & the holes in our current knowledge
Cannabinoids and cannabinoid-like compounds: Biochemical characterization and pharmacological Perspectives
https://romj.org/files/pdf/2023/romj-2023-0107.pdf
Preclinical
In a mouse model of cannabis withdrawal syndrome, they experienced decreased total sleep time
Sleep disturbance after cessation of cannabis administration in mice
https://pubmed.ncbi.nlm.nih.gov/36905178/
How CBD kills lung cancer cells
Synergistic effects of cannabidiol and cytokineinduced killer cells via the modulation of TRPV2 channel and intracellular p-ERK 1/2 expression on non-small cell lung cancer cells
https://assets.researchsquare.com/files/rs-2702281/v1_covered.pdf?c=1680200036
In mice exposed to the persistent organic pollutant perfluorooctane sulfonate, CBD protected the kidney cells from death via its antioxidant effects
Perfluorooctane sulfonate-induced apoptosis in kidney cells by triggering the NOX4/ROS/JNK axis and antagonism of cannabidiol
https://pubmed.ncbi.nlm.nih.gov/36988283/
In a mouse model of increased pain because of stress (biomedical research is a bitch), the positive effects of a number of endocannabinoids
STUDY OF EFFECTS OF NEWLY SYNTHESISED NOCICEPTIN ANALOGUES ON THE ENDOCANNABINOID SYSTEM AND PAIN AFTER CHRONIC IMMOBILIZATION STRESS
https://journal.uctm.edu/node/j2023-3/JCTM_2023_58_21_122-74_pp593-601.pdf
An evergreen note on reading restricted papers:
First stop for seeing if there’s a free version of a paper, use the Google Scholar Chrome extension (Mac version), Google Scholar itself or try ResearchGate.
Three other helpful browser extensions are: Unpaywall, Open Access Button & PaperPanda
For the infamous backdoor, use Sci-Hub – the pirated papers repository (Chrome extension here). This works better for older paper than the stuff that just came out.
For Twitter users, send a Tweet of the paper’s title with the hashtag #icanhazpdf. It works because people are beautiful(ish).
Finally, email the author. They’re almost always happy to oblige because, thanks to the predatory academic publishing system, they don’t make a dollar off of their papers.
the Headlines & Fav Articles
A white paper on the necessity of federal legalization of cannabis for social justice & medical equity
Social Justice and Medical Equity through Federal Legalization of Marijuana
https://esmed.org/MRA/mra/article/view/3697
On how cannabis taxes benefit the black market by our old friend Dr. Jeffrey Miron
Marijuana Taxes Keep Black Markets Thriving
https://policycommons.net/artifacts/3527317/marijuana-taxes-keep-black-markets-thriving/4328104/
In the US House, James Comer launches an investigation into the FDA for refusing to regulate CBD products, demanding that they hand over all related documents
https://www.marijuanamoment.net/congressional-committee-launches-investigation-into-fdas-decision-not-to-regulate-cbd
Go get ‘em Jamey boy.
Winner of headline of the month…
Schrödinger’s Lozenge: Is a lozenge an edible, or an extract? In Canada, the answer depends on if it’s a cannabis product.
https://www.cannabisbusinessexecutive.com/2023/04/schrodingers-lozenge-is-a-lozenge-an-edible-or-an-extract-in-canada-the-answer-depends-on-if-its-a-cannabis-product/
The War on Drugs & Prohibition
DEA Administrator Anne Milgram under investigation for perhaps giving millions of dollars in no-bid contracts to past associates
https://apnews.com/article/dea-corruption-fentanyl-cocaine-drugs-contracts-milgram-ca2131b05d0209d091a10bf3f4e1c008
Never forget that the Federal Bureau of Narcotics (the forerunner of the DEA) grew out of the Bureau of [Alcohol] Prohibition, the federal government’s most notoriously corrupt agency. But like any good god, the FBN grew up to eat its father.
[been reading a lot of mythology with the kids lately. that asshole Zeus being like Harry Anslinger seems like a pretty good parallel]
Colorado’s transportation department giving cannabis gummies to volunteers for the training of cops to recognize the signs of intoxication
https://twitter.com/ColoradoDOT/status/1648843714759106560
[the heads of a dozen readers just snapped up saying where do I sign up?]
On the rollout of Colorado’s safe driving campaign by Jonathan Rose in Regulated State
In perceptions of driving risk, medical users of cannabis were more likely to say it was safer to drive on cannabis than alcohol
Risk perceptions of driving under the influence of cannabis: Comparing medical and non-medical cannabis users
https://www.sciencedirect.com/science/article/abs/pii/S1369847823000347
Yes, it's not good to drive stoned. Your reactions are slower. But I've interviewed so many medical patients who reports that they're much better drivers with a little bit of cannabis because they are suffering less from their disease.
Relatedly, in Canada they found no difference in their motor vehicle or pedestrian/cyclist injury rate after recreational cannabis legalization
The effect of recreational cannabis legalization on rates of traffic injury in Canada
https://pubmed.ncbi.nlm.nih.gov/36908044/
But a review of 31 cases suggested it's a bad idea to mix alcohol & synthetic cannabinoids
Psychomotor performances relevant for driving under the combined effect of ethanol and synthetic cannabinoids: A systematic review
https://pubmed.ncbi.nlm.nih.gov/36911125/
Business & Law
The National Association of Realtors find a decline in property purchases by the cannabis
https://www.nar.realtor/newsroom/nar-report-finds-decline-in-commercial-property-purchases-by-marijuana-industry-increase-in-leasing
Psychedelics, Plant Medicines & Other Psychoactives
Jules Evans has been grappling with the widespread idea that ‘the medicine always gives you what you need’
The Psychoactive Research
[This isn’t a deep dive into all of the science of psychedelics & other psychoactives like I do for the cannabinoids. If a newsletter with all that new science would be of interest to your company or organization, reach out to me]
32 interviews with people on their long-term negative effects from psychedelics
Focusing on the negative: cases of long-term negative psychological responses to psychedelics
https://psyarxiv.com/yzmcj/
In humans, the effects of extended-state DMT
Psychological and physiological effects of extended DMT
https://psyarxiv.com/vg4dp
And an analysis of this DMTx paper by Dr. Andrew Gallimore
Neural entropy & psychedelic drugs
A whole-brain model of the neural entropy increase elicited by psychedelic drugs
https://pubmed.ncbi.nlm.nih.gov/37069186/
The Plant & the History
Growing & Farming
A review on the disposal of waste produced during the cannabis growth process
Opportunities and challenges in waste management within the medicinal cannabis sector
https://www.sciencedirect.com/science/article/abs/pii/S0926669023004041
On the effect of nitrogen fertilization on hemp
NITROGEN FERTILIZATION IMPACT ON HEMP (CANNABIS SATIVA L.) CROP PRODUCTION: A REVIEW.
https://acsess.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/agj2.21345
A review paper on α-terpineol
Recent updates on bioactive properties of α-terpineol
https://www.tandfonline.com/doi/abs/10.1080/10412905.2023.2196515
Animal feed
Giving omega-3 fatty acids to dairy cows improved their insulin sensitivity & immune function as well as modulating their endocannabinoid system
Alpha-linolenic acid modulates systemic and adipose tissue-specific insulin sensitivity, inflammation, and the endocannabinoid system in dairy cows
https://pubmed.ncbi.nlm.nih.gov/37002295/
Industrial use
Using hemp to clean soils polluted by heavy metals
Phytoremediation of Cadmium-, Lead-, and Nickel-Polluted Soils by Industrial Hemp
https://www.mdpi.com/2073-4395/13/4/995
On using nanoemulsions of terpenes as an insecticide
Nanoemulsions of terpene by-products from cannabidiol production have promising insecticidal effect on Callosobruchus maculatus
https://www.sciencedirect.com/science/article/pii/S2405844023023083
CANNABINOID SCIENCE
The Board of the Brazilian Medical Association produced a report on the medical use of cannabis products
Cannabis products: medical use
https://pubmed.ncbi.nlm.nih.gov/36921194/
Mental Health, Sleep & Substance Use Disorders
In young adults using cannabis, their impaired decision-making is mirrored by hyper-connectivity in their corticocerebellar networks
Functional hyperconnectivity between corticocerebellar networks and altered decision making in young adult cannabis users: Evidence from 7T and multivariate pattern analysis
https://pubmed.ncbi.nlm.nih.gov/36924741/
The best predictor for dependence on cannabis is impulsivity & age of onset of use
Investigating predictors of problematic alcohol, cannabis, and nicotine use among legal users of all three substances
https://pubmed.ncbi.nlm.nih.gov/36911131/
And in humans, the chronic use of cannabis may lead it to a glutamate imbalance in the dorsal anterior cingulate [a cognition & motor control brain region] & striatum [a decision-making region], two areas linked to several psychiatric conditions as well as poor impulse control
Chronic cannabis use alters dACC-striatal glutamatergic balance
https://pubmed.ncbi.nlm.nih.gov/37004979/
A clinical review of cannabis for anxiety disorders & PTSD
Cannabis update: Anxiety disorders and post-traumatic stress disorder
https://pubmed.ncbi.nlm.nih.gov/37000126/
A review of the effects of Canadian cannabis legalization on people who use opioids
Implications of Cannabis Legalization on Substance-Related Benefits and Harms for People Who Use Opioids: A Canadian Perspective
https://pubmed.ncbi.nlm.nih.gov/37001172/
In young adults in Washington, cannabis use, including medical use, may increase the risk for non-medical pain reliever misuse
The association between cannabis use and risk of non-medical pain reliever misuse onset among young adults in a legal cannabis context
https://pubmed.ncbi.nlm.nih.gov/37011567/
The Brain & its Diseases
In microglial cells (guardian immune cells of the brain) that model Parkinson's disease, activation of the CB2 receptor inhibited their inflammatory state
Cannabinoid type 2 receptor activation inhibits MPP+-induced M1 differentiation of microglia through activating PI3K/Akt/Nrf2 signal pathway
https://pubmed.ncbi.nlm.nih.gov/36977807/
In a rat model of epilepsy, the relationship between neuroinflammation & neuronal death in the hippocampus & the effect of modulation of the endocannabinoid receptors
Expression of Cytokines and Neurodegeneration in the Rat Hippocampus and Cortex in the Lithium-Pilocarpine Model of Status Epilepticus and the Role of Modulation of Endocannabinoid System
https://pubmed.ncbi.nlm.nih.gov/37047481/
In a rat model of seizures, a new inhibitory descending pathway’s ability to suppress seizures via a blocker of the CB1 receptor
Cannabinoid receptors involved in descending inhibition on spinal seizure-like activity in the phrenic output
https://pubmed.ncbi.nlm.nih.gov/37005282/
In a rat model of absence seizures, an activator of the CB1 receptor worked via the network changes in the hippocampus
Network analysis reveals a role of the hippocampus in absence seizures: The effects of a cannabinoid agonist
https://pubmed.ncbi.nlm.nih.gov/37023553/
Harms, Cannabis Use Disorder & Street Synthetics
Clinical recommendations for diagnosing cannabis use disorder in a medical cannabis patient
Recommendation for Cannabis Use Disorder Diagnosis in a Context of Cannabis for Therapeutic Purposes
https://pubmed.ncbi.nlm.nih.gov/36920375/
Addiction to cannabis may involve the acetylcholine receptors used by nicotine
Role of neuronal nicotinic acetylcholine receptors in cannabinoid dependence
https://pubmed.ncbi.nlm.nih.gov/37001709/
Hormones, Reproduction & Maternal Effects
In a test of the effect of THC on women in various parts of their cycle, the impairments induced by THC in inhibitory control are not affected by cycle-related fluctuations in estradiol levels
Impaired inhibition after delta-9-tetrahydrocannabinol in women not related to circulating estradiol levels
https://pubmed.ncbi.nlm.nih.gov/37004978/
The Lungs
A review of the cannabinoids & how they affect the immune system of the lungs
Modulation of pulmonary immune function by inhaled cannabis products and consequences for lung disease
https://pubmed.ncbi.nlm.nih.gov/36978106/
On the negative byproducts formed from vaping CBD that activate stress genes
Vaping Induced Cannabidiol (CBD) Oxidation Product CBD Quinone Forms Protein Adducts with KEAP1 and Activates KEAP1-Nrf2 Genes
https://pubmed.ncbi.nlm.nih.gov/36999736/
The Guts & Oral Health
Among patients with inflammatory bowel disease, cannabis use did not increase their 30-day readmission for Crohn's disease but did for ulcerative colitis
Cannabis Use and Its Association With Thirty- and Ninety-Day Hospital Readmissions for Patients Admitted for an Inflammatory Bowel Disease Exacerbation
https://pubmed.ncbi.nlm.nih.gov/36895626/
On implant dentistry & cannabis use
Marijuana - Clinical Concerns for Implant Dentistry - Part 2
https://pubmed.ncbi.nlm.nih.gov/36913697/
Cancer
In metastatic tumors, how cannabinoids can turn off the tools the cancer uses to evade the immune system
Specific cannabinoids revive adaptive immunity by reversing immune evasion mechanisms in metastatic tumours
https://pubmed.ncbi.nlm.nih.gov/36923728/
Think Mission Impossible, but with tumor cells that slip around the world with forged passports.
New cannabinoid drugs for killing cancer
Development of Several Pharmaceutical Formulations of Cannabinoids in Cancer Drug Discovery
https://www.pharmacologyonline.org/fullpapers2023/004_capasso.pdf
Pain, Inflammation & Surgeries
In trauma patients who tested positive for cannabis [or cocaine], they had a higher need for surgery as well as an increased risk of complications
Trends and outcomes of trauma patients positive to marijuana and cocaine
https://pubmed.ncbi.nlm.nih.gov/37000193/
Genitourinary System
In kidney transplant patients, increased anandamide & 2AG levels after their surgery were correlated with increased inflammatory markers
Dynamics of changes in the concentrations of anandamide and 2-arachidonoylglycerol and their impact on the carbohydrate-lipid metabolism in patients after kidney transplantation in the follow-up study
https://ojs.pum.edu.pl/pomjlifesci/article/view/898
A case report of a teen with acute kidney injury from the use of synthetic cannabinoids
Synthetic cannabinoid-associated acute interstitial nephritis: An emerging cause of pediatric acute kidney injury?
https://pubmed.ncbi.nlm.nih.gov/37006641/
The Eyes
Alcohol causes more impairment to the accommodation dynamics [muscle adjustments of the eye to maintain focus] than smoked cannabis
Comparison of the influence of alcohol and cannabis on the dynamics of the accommodative response
https://pubmed.ncbi.nlm.nih.gov/36976357/
Cool Chemistry
On making CBD capsules using a nano-micelle system for better bioavailability
Solubility enhancement and antioxidation maintenance of CBD encapsulated in the P407-RUB nano-micelle system
https://pubmed.ncbi.nlm.nih.gov/36999183/
or making microcapsules of full-spectrum extract
Chitosan-Coated Alginate Microcapsules of a Full-Spectrum Cannabis Extract: Characterization, Long-Term Stability and In Vitro Bioaccessibility
https://pubmed.ncbi.nlm.nih.gov/36986720/
New drugs to activate the CB2 receptor with a focus on inflammation
Novel Cannabinoid Receptor 2 (CB2) Low Lipophilicity Agonists Produce Distinct cAMP and Arrestin Signalling Kinetics without Bias
https://pubmed.ncbi.nlm.nih.gov/37047385/
Thanks.
- lex
PS: For my music of the week, I don’t usually spend the majority of my week listening to it, but something about Jack Fascinato had me listening to him several hours a day. I first got into him because of the fun of his ‘Palm Springs Suite’ – but apparently it was the space age pop of ‘Music From A Surplus Store’ that made him an infamous darling. He also helped to arrange the music for the legendary country crossover star Tennessee Ernie Ford, including the undying hit, ‘Sixteen Tons’. And in a piece of work close to my heart, he created the music for the circus segment of the animated short, ‘Gerald McBoing-Boing’, a classic created by Dr. Seuss for neurodivergent children.