C&P#60: the horse edition! + cannabis & sports + monkey monogamy
C&P#60: the horse edition! + cannabis & sports + monkey monogamy
Alabama only allows peach-flavored edibles + DEA muddies the waters
Hello everyone,
Welcome to the 60th edition of Cannabinoids & the People, a weekly newsletter where I collect all the new cannabinoid science. You can check out last week’s issue here & if you haven’t subscribed yet, please do. Paid subscriptions are here.
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As always, here’s the Living Glossary of Cannabinoid Terms & at the bottom is the album of the week.
This a free offering from my company White Whale Creations. I produce educational content for cannabis & psychedelic companies: writing, science archives, social media content, newsletters & podcasts. Here’s my portfolio. Reach out about working together.
This week…
The horse edition!
Cannabis for the concussions of soccer & your best genetic variants to be a top volleyball player
More negative reproductive effects from CBD & THC
Word of the week: thanatotranscriptome
For a dog with compulsive disorder, combining cannabis & melatonin
Good news! CBD will not alter your stallion’s libido or sperm production
1990s History Corner: Humboldt’s only strip club
The Brazilian Journal of Pain has a special cannabinoid issue
Conference Corner: data from the American Physiology Summit 2023 Meeting
A new psychedelic neuroplasticity pathway proposed
A request to spread the word
This newsletter only spreads by word of mouth – so please forward to colleagues & tell your friends & relatives.
Sponsor: PlusCBD’s customer service
Another reason to buy your CBD products from PlusCBD is their excellent customer service. You can call them anytime at 1-855-758-7223 with questions about their products or how to use them. To learn more about the science of CBD, THC, PEA & the endocannabinoid system, you can see it all at their science archive CVResearch.info.
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Buy their excellent products today at PlusCBDoil.com.
My work this week:
(No videos this week. Strep throat)
My European Cannabis Report for Pro Cannabis Media: EU removes hemp leaves from the Novel Food Catalogue + Malta finetunes their cannabis association rules + Lithuania moves towards decrim
My platforms: Linktree
YouTube for educational videos, lectures & shorts on new cannabinoid science
My podcasts
Anandamide; or, the People: my graphic novel series on cannabis, the endocannabinoid system & the War on Drugs based on Moby-Dick
LinkedIn, Twitter & my TikTok on books, hermeticism, science & history
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Best Of Cannabinoid Science...
A Who's Who of researchers on the lessons they've learned from the last 30 years of targeting the endocannabinoid system
Goods and bads of endocannabinoid system as a therapeutic target: Lessons learned after 30 years
https://pubmed.ncbi.nlm.nih.gov/37164640/
If you wanted to have a cannabinoid research orgy, this would be who you would invite.
Clinical
In chronic pain patients, three months of medical cannabis cause significant reductions in self-reported pain intensity & pain interference as well as significant improvements in quality of life, general health, mood/depression & sleep
Medicinal cannabis for pain: Real-world data on three-month changes in symptoms and quality of life
https://journals.sagepub.com/doi/pdf/10.1177/20503245231172535
In football (soccer) players with concussions, those using cannabis had less impairment & neuroinflammation
The modulatory role of cannabis use in subconcussive neural injury
https://www.sciencedirect.com/science/article/pii/S2589004223010258
In top volleyball players, a certain genetic variant of their FAAH enzyme (C385A) “was shown to be significantly associated with superior athletic achievements”
Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players
https://www.mdpi.com/2073-4425/14/6/1164
In the thesis project of the week, monogamous monkeys had more dense CB1 receptor axons in their anterior cingulate cortex (a brain area of social cognition) then non-monogamous monkeys
CANNABINOID RECEPTOR TYPE 1 (CB1) DENSITIES IN MONOGAMOUS AND NON-MONOGAMOUS NEW WORLD MONKEYS
https://etd.ohiolink.edu/apexprod/rws_etd/send_file/send?accession=ksuhonors1683929934613469&disposition=inline
An analysis of why Germans are being prescribed cannabinoids
Prescriptions of Cannabinoid Drugs, 2019-2022
https://pubmed.ncbi.nlm.nih.gov/37222029/
“The most common indication in both data sets was non-cancer pain (BEK 54%, survey 68%). The second most common indications amongst the BEK [Barmer Ersatzkasse health insurance fund ] diagnoses were from oncology and palliative situations (30%) and neurological disorders amongst BfArM diagnoses (14%). The remaining indications in both data sets were predominantly diagnoses from psychiatry (tic disorders, depressive disorders) and internal medicine (chronic obstructive pulmonary disease [COPD], Crohn’s disease).”
Also, the four classes of Canadians using cannabis for medical reasons
Characterizing heterogeneity among people who use cannabis for medicinal reasons: A latent class analysis of a nationally representative Canadian sample
https://pubmed.ncbi.nlm.nih.gov/37247474/
- a non-daily cannabis flower for mental health and sleep class (39.56% of the sample)
- a non-daily cannabis flower for pain class (26.41% of the sample)
- a non-daily cannabis oil for physical health class (20.15% of the sample)
- a daily multi-form cannabis for mental health & non-medical reasons class (13.88% of the sample)
A survey of physicians finds that they say they don't know enough about CBD & are hesitant to recommend it for anything besides chronic non-cancer pain or anxiety
Differences in Cannabidiol-Related Attitudes and Practice Behaviors Between U.S. Primary Care Physicians Practicing in a Single Health Care System Across States With and Without Marijuana Legalization
https://pubmed.ncbi.nlm.nih.gov/37220016/
Airplane pilots, cannabis & the thanatotranscriptome
Effects of Cannabinoids and Postmortem Interval on Gene Expression: Considerations for the Forensic Genetic Analysis of Civil Aviation Accident Victims
https://rosap.ntl.bts.gov/view/dot/67372
This federal report hopes to figure out a way to measure the cognitive impairments from cannabis after someone died in an airplane crash. In a unique method, they consider that because cannabis changes the expressions of genes & their biomarkers, perhaps this could be a postmortem measurement of impairment. Unfortunately, the matter is complicated by the fact that gene expression levels continue to change throughout the postmortem interval. They review the studies of cannabis exposure on gene expression in different tissues & the possibility of characterizing the cannabinoid thanatotranscriptome, or genes whose expression changes significantly following organismal death.”
In a dog with compulsive disorder, using cannabis & melatonin lowered their compulsive episodes
Combining cannabis and melatonin treatment with a rehabilitation program improved symptoms in a dog with compulsive disorder: A case report
https://pubmed.ncbi.nlm.nih.gov/37245289/
Horses!
In a survey of equine industry professionals, the majority believed CBD should be legal in competition, that it provided benefits for the horses such as calming & many believed it to reduce inflammation as effectively as NSAIDs
Industry perceptions of cannabidiol use in horses
https://www.sciencedirect.com/science/article/abs/pii/S073708062300309X
In stallions, CBD did not alter their testosterone levels or sperm production
Effects of oral supplementation of cannabidiol on stallion spermatogenesis
https://www.sciencedirect.com/science/article/abs/pii/S0737080623002277
And it does not seem to affect their libido
The effects of cannabidiol on libido and heart rate in stallions
https://www.sciencedirect.com/science/article/abs/pii/S0737080623002289
In thoroughbred horses, CBD was no longer detectable in their urine after 7 days but one metabolite was detectable in their blood serum after 10 days
Detection time following administration of cannabidiol applied as an oral emulsified solution in Thoroughbred horses
https://www.sciencedirect.com/science/article/abs/pii/S0737080623001053
In thoroughbred horses, a month of hemp seed oil improved the fatty acid profile in their skeletal muscle & the synovial fluid of the joints, suggesting help for inflammation
Hemp seed oil as a novel fatty acid supplement for horses
https://www.sciencedirect.com/science/article/abs/pii/S0737080623001454
A thesis project on using hemp seed meal to feed horses
Hempseed Meal: A Potential Feedstuff in Equine Rations
https://www.proquest.com/openview/89cfa8b50d503ac889cc7fd0d0565959/1?pq-origsite=gscholar&cbl=18750&diss=y
An evergreen note on reading restricted papers:
First stop for seeing if there’s a free version of a paper, use the Google Scholar Chrome extension (Mac version), Google Scholar itself or try ResearchGate.
Three other helpful browser extensions are: Unpaywall, Open Access Button & PaperPanda
For the infamous backdoor, use Sci-Hub – the pirated papers repository (Chrome extension here). This works better for older paper than the stuff that just came out.
For Twitter users, send a Tweet of the paper’s title with the hashtag #icanhazpdf. It works because people are beautiful(ish).
Finally, email the author. They’re almost always happy to oblige because, thanks to the predatory academic publishing system, they don’t make a dollar off of their papers.
the Headlines & Fav Articles
DEA releases letter to clarify the legal status of the minor cannabinoids, but just confuses everyone
https://www.marijuanamoment.net/dea-discusses-legal-status-of-minor-cannabinoids-like-thca-and-hydrogenated-cbd
Alabama licenses its first medical cannabis operators, but the edibles are only allowed to be one flavor: peach🍑
https://reason.com/2023/06/14/why-does-alabama-only-let-you-consume-peach-flavored-edibles
Apparently, they think that peach is the flavor that kids hate the most.
But don’t they know what that emoji means these days?
A suit alleges that that Glass House Brands of California is one of the state’s largest black market suppliers of cannabis
https://www.greenmarketreport.com/glass-house-brands-one-of-the-largest-illicit-cannabis-dealers-in-california-lawsuit-claims
Leafly removes articles investigating worker death at Trulieve facility
https://www.ganjapreneur.com/leafly-removes-articles-investigating-worker-death-at-trulieve-facility/
The video game streaming platform Twitch to allow alcohol ads but not cannabis
https://www.marijuanamoment.net/amazon-owned-twitch-bans-streamers-from-promoting-marijuana-but-allows-alcohol-branding-in-policy-update
1990s History Corner: ‘Toy Cars and Camouflage: Tales from Humboldt’s Only Strip Club’
https://hightimes.com/culture/toy-cars-and-camouflage-tales-from-humboldts-only-strip-club/
The War on Drugs & Prohibition
In a double-blind test of driving, the majority of those who smoked cannabis failed field sobriety tests (though half of those smoked the placebo also failed) but there was no correlation between THC concentrations in bodily fluids & performance in a driving simulator
Driving Under the Influence of Cannabis: Impact of Combining Toxicology Testing with Field Sobriety Tests
https://academic.oup.com/clinchem/advance-article/doi/10.1093/clinchem/hvad054/7179849
This meta-analysis find that cannabis does not increase the risk of crashing & that its co-use with alcohol does not exacerbate the negatives of alcohol
Does the co-use of cannabis exacerbate the effect of alcohol on the risk of crashing? A systematic review and meta-analysis
https://journals.sagepub.com/doi/pdf/10.1177/20503245231177334
Business & Law
On Native Americans & cannabis: a legal analysis of the history & current issues
Burning Questions: Changing Legal Narratives on Cannabis in Indian Country
https://scholarship.law.missouri.edu/cgi/viewcontent.cgi?article=2073&context=facpubs
On the many states moving to provide tax relief from the federal 280E tax provision that hamstrings all cannabis businesses
https://www.greenmarketreport.com/connecticut-latest-in-string-of-states-to-enact-280e-relief
A labor market analysis finds that cannabis legalization increases the wages of young adults but has no significant effect on the wages of adults
The Effect of Non-Medical Marijuana Legalization on Labor Market Outcomes
https://www.researchgate.net/publication/370944459_The_Effect_of_Non-Medical_Marijuana_Legalization_on_Labor_Market_Outcomes
An analysis of UV radiation exposure in cannabis grows finds that it's not a huge problem but it should be paid attention to
Ultraviolet radiation exposure in cannabis growing facilities
https://pubmed.ncbi.nlm.nih.gov/37146269/
Psychedelics, Plant Medicines & Other Psychoactives
The big article making the rounds is about MDMA transforming a white supremacist by Rachel Nuwer
https://www.bbc.com/future/article/20230614-how-a-dose-of-mdma-transformed-a-white-supremacist
A long post on the DMT entities
The Psychoactive Research
[This isn’t a deep dive into all of the science of psychedelics & other psychoactives like I do for the cannabinoids. If a newsletter with all that new science would be of interest to your company or organization, reach out to me]
The hot psychedelic article of the week: a new signaling pathway proposed for their ability to promote neuroplasticity: TrkB
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
https://pubmed.ncbi.nlm.nih.gov/37280397/
And an analysis by Zach Haigney of the Trip Report
In adults with cancer & depression, a single dose of psilocybin helped the majority of them with their depression
Long term efficacy of psilocybin in patients with cancer and major depressive disorder (MDD)
https://ascopubs.org/doi/abs/10.1200/JCO.2023.41.16_suppl.12021
And similar results in another clinical study
HOPE: A Pilot Study of Psilocybin Enhanced Group Psychotherapy in Patients with Cancer
https://www.sciencedirect.com/science/article/abs/pii/S0885392423005304
In mice, how psychedelics reopen the social reward learning critical period
Psychedelics reopen the social reward learning critical period
https://pubmed.ncbi.nlm.nih.gov/37316665/
In a rat model of alcohol use disorder, while psilocybin did not affect alcohol drinking or relapse, it did help to block the reconsolidation of alcohol-related memories
Psilocybin prevents reinstatement of alcohol seeking by disrupting the reconsolidation of alcohol-related memories
https://link.springer.com/article/10.1007/s00213-023-06384-w
The Plant & the History
In the Pyrenees mountains of Spain, there has been an increase in cannabis pollen since the 1980s
A recent Cannabis pollen increase on the Iberian Pyrenees
https://pubmed.ncbi.nlm.nih.gov/37160180/
Growing & Farming
A review of new breeding techniques & genome editing tools for cannabis
Challenges and potentials of new breeding techniques in Cannabis sativa
https://www.frontiersin.org/articles/10.3389/fpls.2023.1154332/full
An analysis of cross breeding different hemp varieties for their oil content & seed yield
Evaluation of different hemp (Cannabis sativa L.) progenies resulting from crosses with focus on oil content and seed yield
https://www.sciencedirect.com/science/article/abs/pii/S0926669023006581
On why salicylic acid increases cannabinoid production via hormonal control
Hormonal control of promoter activities of Cannabis sativa prenyltransferase 1 and 4 and salicylic acid mediated regulation of cannabinoid biosynthesis
https://pubmed.ncbi.nlm.nih.gov/37244890/
On using anti-auxins to help with the micropropagation of cannabis
New PEO-IAA-Inspired Anti-Auxins: Synthesis, Biological Activity, and Possible Application in Hemp (Cannabis Sativa L.) Micropropagation
https://link.springer.com/article/10.1007/s00344-023-11031-x
On the bud rot of greenhouse-grown cannabis caused by Botrytis cinerea fungus
Understanding bud rot development, caused by Botrytis cinerea, on cannabis (Cannabis sativa L.) plants grown under greenhouse conditions
https://cdnsciencepub.com/doi/pdf/10.1139/cjb-2022-0139?download=true
In India, the detection of the bacteria Candidatus Phytoplasma Australasia on hemp
Identification of 16SrII group phytoplasma strain associated with witches’ broom of spinach and hemp in India
https://www.indianjournals.com/ijor.aspx?target=ijor:mollicutes&volume=13&issue=1&article=053
On evaluating the different tools for analyzing the DNA of the microbial communities on hemp stems
Estimating the bias related to DNA recovery from hemp stems for retting microbial community investigation
https://pubmed.ncbi.nlm.nih.gov/37227475/
Nutrition
A new product! Spray dried hempseed milk
Physicochemical Properties and Characterization of a New Product: Spray Dried Hempseed Milk
https://pubmed.ncbi.nlm.nih.gov/37145380/
Industrial Use
The BBC with hemp houses around the world
https://www.bbc.com/future/article/20230614-the-buildings-constructed-from-cannabis
On turning cannabis waste into cellulose nanomaterials
Valorization of cannabis green waste to cellulose nanomaterials via phosphoric acid hydrolysis
https://www.sciencedirect.com/science/article/pii/S0926669023006532
CANNABINOID SCIENCE
The American Physiology Summit 2023 Meeting
In frequent cannabis users, they had significantly lower functioning of their microvasculature (the three small blood vessels: arterioles, capillaries & venules)
Microvascular Health is Reduced in Frequent Cannabis Users
https://journals.physiology.org/doi/abs/10.1152/physiol.2023.38.S1.5730193
In a mouse model of colitis, dietary CBD suppressed inflammation & enhanced gut barrier function via the PKA & AMPK signaling pathways
Dietary cannabidiol activates PKA/ERK/AMPK signaling and attenuates chronic inflammation and leaky gut in DSS-induced colitis mice
https://journals.physiology.org/doi/abs/10.1152/physiol.2023.38.S1.5789473
In frog neurons, CBD did not change the frequency of their action potentials but it did change their strength
Impact of cannabidiol and lamotrigine on parameters of action potentials in sciatic nerves of frogs https://journals.physiology.org/doi/abs/10.1152/physiol.2023.38.S1.5733999
In a model of inflammatory bowel disease, white blood cell migration was inhibited by anandamide, CBD & AM-1241 (an activator of the CB2 receptor)
Development of a new cannabinoid-based therapy to treat inflammatory bowel disease
https://journals.physiology.org/doi/abs/10.1152/physiol.2023.38.S1.5733403
In mice, 8 weeks of CBG lowered their blood pressure
Chronic cannabigerol administration lowers blood pressure in phenotypically normal mice
https://journals.physiology.org/doi/abs/10.1152/physiol.2023.38.S1.5726031
In a mouse model of chemotherapy, inhibiting their FAAH enzyme (which raises the level of anandamide) protected the kidneys from injury
Pharmacological inhibition of the endocannabinoid anandamide metabolism alleviates cisplatin-induced acute kidney injury
https://journals.physiology.org/doi/abs/10.1152/physiol.2023.38.S1.5730277
In a mouse model of eclampsia (seizures in pregnant women), reduced uterine perfusion pressure increased CB1 receptors in the hippocampus, causing more seizures when their CB1 receptors are blocked but protecting them against worse seizures
Reduced uterine perfusion increases hippocampal cannabinoid receptor 1 expression and reduces pentylenetetrazol-induced seizures after rimonabant pre-treatment
https://journals.physiology.org/doi/abs/10.1152/physiol.2023.38.S1.5729959
In a mouse model of fetal lung development, CBD & THC (& nicotine) increased cellular senescence (aging)
Co-exposure to cannabis and nicotine during pregnancy alters fetal lung development
https://journals.physiology.org/doi/abs/10.1152/physiol.2023.38.S1.5764584
Clinical Use
A review of the therapeutic effects & molecular mechanisms of cannabis
Cannabis Sativa in Phytotherapy: Reappraisal of Therapeutic Potential and Regulatory Aspects
https://pubmed.ncbi.nlm.nih.gov/37157219/
An analysis of the barriers of access to CBD for children with neuro disabilities
Barriers for access to cannabidiol as a treatment option for children with neuro-diverse disabilities: A qualitative key informants method
https://www.sciencedirect.com/science/article/abs/pii/S235255252300035X
In dead bodies, how to best measure cannabinoid levels
Comparison between Blood, Non-Blood Fluids and Tissue Specimens for the Analysis of Cannabinoid Metabolites in Cannabis-Related Post-Mortem Cases
https://www.mdpi.com/2673-6756/3/2/25
Adolescents
A review on the effects of accidental cannabis exposure in children
Cannabis Toxicity in Children and Adolescent
https://pubmed.ncbi.nlm.nih.gov/37159059/
In UK public health data, the greater number of adverse childhood experiences, the more likelihood to experience problematic adolescent cannabis use
Adverse childhood experiences and adolescent cannabis use trajectories: findings from a longitudinal UK birth cohort
https://pubmed.ncbi.nlm.nih.gov/37244674/
In adolescent mice, the synthetic cannabinoid JWH-018 caused long lasting neurobiological changes related to psychotic symptoms with gender dependent effects
Adolescent exposure to the Spice/K2 cannabinoid JWH-018 impairs sensorimotor gating and alters cortical perineuronal nets in a sex-dependent manner
https://pubmed.ncbi.nlm.nih.gov/37225721/
Neurology & Brain Diseases
On the efficacy of using CBD for treatment-resistant epilepsy
Efficacy of cannabidiol in convulsive and nonconvulsive seizure types associated with treatment-resistant epilepsies in the Expanded Access Program
https://pubmed.ncbi.nlm.nih.gov/37243404/
In Canada, a survey of epilepsy patients finds that those with drug-resistant epilepsy often used cannabis to improve their seizure management
Nationwide Study of Postlegalization Marijuana Use Among Patients With Epilepsy in Canada
https://pubmed.ncbi.nlm.nih.gov/37251367/
In neurons, CBD protected them from the dopamine toxicity of paraquat via antioxidant & antiapoptotic (cellular suicide) effects, suggesting them as a treatment for Parkinson's disease
Cannabidiol Protects Dopaminergic-like Neurons against Paraquat- and Maneb-Induced Cell Death through Safeguarding DJ-1CYS106 and Caspase 3 Independently of Cannabinoid Receptors: Relevance in Parkinson's Disease
https://pubmed.ncbi.nlm.nih.gov/37220279/
In elderly mice who underwent an operation, oral β-caryophyllene (the common cannabis terpene) lessened their neuroinflammation dramatically
Effects of oral β-caryophyllene (BCP) treatment on perioperative neurocognitive disorders: Attenuation of neuroinflammation associated with microglial activation and reinforcement of autophagy activity in aged mice
https://www.sciencedirect.com/science/article/abs/pii/S0006899323001968
In a mouse model of Alzheimer's, the cannabis terpenes linalool & cineol combined well with aerobic exercise to cause a protective effect via the genetic expression of Bdnf, Ngf & Creb
The Effect of Linalool, Cineole, Beta bourbonin and Aerobic Exercises as Protective Approaches in Mice with Alzheimer's Disease
https://jims.mui.ac.ir/article_30938.html?lang=en
Mental Health & Substance Use Disorders
A review of drugs to treat psychosis find help from CBD, modafinil & ketamine
Use of psychoactive substances as a treatment for psychosis
https://pubmed.ncbi.nlm.nih.gov/37231549/
In an analysis of public health data, cannabis use disorder was associated with the later increased risk of psychotic & nonpsychotic bipolar disorder as well as unipolar depression
Cannabis Use Disorder and Subsequent Risk of Psychotic and Nonpsychotic Unipolar Depression and Bipolar Disorder
https://pubmed.ncbi.nlm.nih.gov/37223912/
An analysis of substance use disorders finds that cannabis use disorders increases the likelihood of also having opioid use disorder by 6.69 times & combining that with nicotine or alcohol use disorder increases those odds even more
Associations of alcohol use disorder, cannabis use disorder, and nicotine dependence with concurrent opioid use disorder in U.S. adults
https://pubmed.ncbi.nlm.nih.gov/37166911/
In Chinese patients with depression, an analysis of the genetic variations of their endocannabinoid signaling pathway finds changes related to mitochondrial function (powerhouse of the cell)
Genetic variations in the retrograde endocannabinoid signaling pathway in Chinese patients with major depressive disorder
https://pubmed.ncbi.nlm.nih.gov/37168668/
In a mouse model of cocaine use disorder, oleoylethanolamide (an analog of anandamide) did not alter their taste for blow but it did block the increase of dopamine D1 receptor genes in the striatum & hippocampus as well as D2 & CB1 in the striatum
Oleoylethanolamide attenuates cocaine-primed reinstatement and alters dopaminergic gene expression in the striatum
https://pubmed.ncbi.nlm.nih.gov/37226219/
Harms & Cannabis Use Disorder
From Reddit, the self-reported negative effects of delta-8 THC
Self-reported adverse events associated with ∆8-Tetrahydrocannabinol (Delta-8-THC) Us
https://pubmed.ncbi.nlm.nih.gov/37217977/
“Psychiatric disorders were the most frequently cited system organ class in r/Delta8 adverse event reports, mentioned in 41.2% … of reports, followed by respiratory, thoracic and mediastinal disorders … and nervous system disorders …Anxiety …Cough … and Paranoia … were the most frequently cited preferred terms in adverse event reports… The findings of this case series suggest that most of the adverse events reported by delta-8-THC users are like those reported during acute cannabis intoxication.”
Synthetic Cannabinoids
An analysis of 32 potential synthetic cannabinoids & their effect on mouse neurons
Pharmacological insights emerging from the characterization of a large collection of synthetic cannabinoid receptor agonists designer drugs
https://pubmed.ncbi.nlm.nih.gov/37236027/
Pain, Inflammation & Surgeries
Veterans who use cannabis for chronic pain are more likely to develop cannabis use disorder
Increasing risk of cannabis use disorder among U.S. veterans with chronic pain: 2005-2019
https://pubmed.ncbi.nlm.nih.gov/37159542/
A topical anandamide formulation for neuropathic pain
Novel topical anandamide formulation for alleviating peripheral neuropathic pain
https://pubmed.ncbi.nlm.nih.gov/37245739/
In a mouse model of peripheral neuropathic pain from trauma, activating the CB2 receptor with the drug COR167 lowered pain levels via lowering the expression of HDAC1 in the microglia (guardian immune cells of the brain), reducing NF-kB activation & increasing anti-inflammatory cytokines
The Selective CB2 Agonist COR167 Reduced Symptoms in a Mice Model of Trauma-Induced Peripheral Neuropathy through HDAC-1 Inhibition
https://www.mdpi.com/2227-9059/11/6/1546
A special cannabinoid issue of the Brazilian Journal of Pain:
https://www.scielo.br/j/brjp/aop
Gaps in our knowledge and future research on the endocannabinoid system and the painful phenomenon
https://www.scielo.br/j/brjp/a/q7h4mzQxMvJFKq58g7m8NYj/?lang=en
Cannabinoids and the new horizons in the treatment of pain phenomenon
https://www.scielo.br/j/brjp/a/x7DH4nS3yWcGsKHQzxjPSjy/?lang=en
Painful behavior and medicinal cannabis
https://www.scielo.br/j/brjp/a/4jJdrn6RrZ6hFLZ85mXyYzq/?lang=en
Efficacy and analgesic potency of cannabinoids considering current available data
https://www.scielo.br/j/brjp/a/kZMkhXyxH44sNmryKJpqmmJ/?lang=en
Anti-inflammatory effects of cannabinoids
https://www.scielo.br/j/brjp/a/kJFVFMnvSMw9K5BpymRfNyC/?lang=en
Adverse effects of cannabinoid use: what is the safety paradigm?
https://www.scielo.br/j/brjp/a/R4TdHZ7fqGyWYvkHCtcj8rz/?lang=en
Cannabinoid therapy within the Unified Health System, perspectives in relation to pain treatment
https://www.scielo.br/j/brjp/a/mvnHhGfVD5RvFSKNyH3bSmB/?lang=en
Neuropathies and the use of cannabinoids as a therapeutic strategy
https://www.scielo.br/j/brjp/a/6dWVkHQskmSbVZRGVN7PkCk/?lang=en
Use of cannabis medicine for the treatment of spasticity-associated pain
https://www.scielo.br/j/brjp/a/9syCLsBmLJF3g53GQvKMxXB/?lang=en
Integrative approach to the therapeutic use of cannabis for orofacial pain
https://www.scielo.br/j/brjp/a/wJTJqrWzTwTYmQRcHCMDMBH/?lang=en
Use of medical cannabis in the treatment of endometriosis
https://www.scielo.br/j/brjp/a/MZZJsdgFLTzQxtFz9JPszzj/?lang=en
Cannabinoids for the treatment of autism and childhood epilepsy
https://www.scielo.br/j/brjp/a/Xm4S6D9xV5LqYggqBR5Ndtb/?lang=en
Genetic testing for cannabinoid use
https://www.scielo.br/j/brjp/a/MWr4BXFM8PtTh9sF9QKFKBG/?lang=en
The molecular machinery required to process endocannabinoids lipid signaling and their respective receptors
https://www.scielo.br/j/brjp/a/HFzKKWJYcFbfBx5ZQfNbCPz/?lang=en
Glia function in the endocanabinoid system: narrative review
https://www.scielo.br/j/brjp/a/3G8VgBR6DkwGhzLXP33RXrR/?lang=en
Female-specific, Reproduction & Hormones
In mothers exposed to both cannabis & Superstorm Sandy, their children “had a 31-fold increased risk of disruptive behavioural disorders (DBDs) and a seven-fold increased risk of anxiety disorders”
Association of maternal exposure to Superstorm Sandy and maternal cannabis use with development of psychopathology among offspring: the Stress in Pregnancy Study
https://pubmed.ncbi.nlm.nih.gov/37231817/
In Ontario, legalization slightly increased cannabis use among pregnant women & those using cannabis had greater odds of delivering pre-term or requiring neonatal intensive care
Acute care related to cannabis use during pregnancy after the legalization of nonmedical cannabis in Ontario
https://pubmed.ncbi.nlm.nih.gov/37220929/
In mice, the negative effects of THC on the testicles & production of sperm may be mediated by the hormone ghrelin & its modulation of androgen hormone production
LOCALIZATION OF GHRELIN IN TESTES OF MICE ADMINISTERED ORALLY WITH LEPIDIUM MEYENII (MACA), AND WITH TETRAHYDROCANNABINOL CHRONIC EXPOSUR
https://www.iris.unina.it/handle/11588/921870
In zebrafish (a common model organism for reproduction), CBD caused them to spawn less, reduced sperm & egg quality, altered sex hormone levels & the offspring had a higher mortality & malformation rate, possibly because of an increased rate of apoptosis (cellular suicide)
Short-term exposure of Cannabidiol on Zebrafish (Danio Rerio): Reproductive Toxicity
https://pubmed.ncbi.nlm.nih.gov/37222891/
The Heart
A review of the negative cardiovascular effects of cannabis
Substances of abuse and cardiovascular risk: cannabinoids
https://pubmed.ncbi.nlm.nih.gov/37227205/
A case report of a young person with a heart attack potentially from cannabis consumption
Coronary thrombosis and cannabis abuse: a case report
https://pubmed.ncbi.nlm.nih.gov/37227208/
In pig brain arteries, a drug that activates the CB1 & C2 receptor relaxed them via the NOS, COX & EDHF pathways
CP55940-induced vasorelaxation is endothelial-dependent and mediated by the CB1R through NOS, COX and EDHF pathways in porcine cerebral arteries
https://pubmed.ncbi.nlm.nih.gov/37230164/
The Guts, the Microbiome & Oral Health
A case report of cannabis hyperemesis syndrome along with recurrent kidney stones
A Case of a Patient With Cannabis Hyperemesis Syndrome Along With Recurrent Nephrolithiasis
https://pubmed.ncbi.nlm.nih.gov/37159782/
On kidney stones, my dad got to know Major Dick Winters, the hero of ‘Band of Brothers’, who got shot a few times during World War II. Dick said he'd rather be shot again than have another kidney stone.
Cancer & Chemotherapy
A survey of why patients with cancer were applying to use medical cannabis
Use of Medical Cannabis by Patients With Cancer: Attitudes, Knowledge, and Practice
https://pubmed.ncbi.nlm.nih.gov/37244526/
Cool Chemistry
How to use E coli bacteria to produce CBGA & CBG
Biosynthesis of cannabigerol and cannabigerolic acid: the gateways to further cannabinoid production
https://pubmed.ncbi.nlm.nih.gov/37323510/
A three-dimensional analysis of CBG
Bioactivity of the cannabigerol cannabinoid and its analogues - the role of 3-dimensional conformation
https://pubmed.ncbi.nlm.nih.gov/37222259/
An analysis on why different drugs activate CB1 and/or CB2
Distinct activation mechanisms regulate subtype selectivity of Cannabinoid receptors
https://pubmed.ncbi.nlm.nih.gov/37147497/
Thanks.
- lex
PS: For some immaculate slide guitar, the album this week is ‘Two Bugs And A Roach’ by the great Earl Hooker. After a lifetime of wandering & recording, Hooker passed away at the age of 41 from tuberculosis. As BB King said, "to me he is the best of modern guitarists. Period. With the slide he was the best. It was nobody else like him, he was just one of a kind."