C&P#77: Great data on CBN, THCV & CBD + cannabis for cerebral palsy, Fabry disease & Angelman syndrome
250k arrested for cannabis last year. Ain’t that some shit…
Hello everyone,
Welcome to the 77th edition of Cannabinoids & the People, a weekly newsletter where I collect all the new cannabinoid science. You can check out last week’s issue here & if you haven’t subscribed yet, please do. Sign up for a paid subscription to support my work disseminating all of the cannabinoid science.
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Read my free How-To Guides, watch my Three-Minute Cannabinoid Science videos or book a session with me here.As always, here’s the Glossary of Cannabinoid Terms & at the bottom is the album of the week.
Announcements
For this newsletter, I just passed the 300,000 words mark. That’s longer than Moby Dick or Joyce’s Ulysses. So if you ever wanted to support this newsletter with a paid subscription, now would be an excellent time.
Creating this newsletter takes about half my working week & I put it all out there for free to get this information into the hands of patients, doctors & activists. Even 5 dollars a month would be a heartwarming show of support. Thank you.
(Also, I’m curious if there is anyone out there who has read every word of Cannabinoids & the People?
I bet there must be one…)
This week…
Cannabinoids for cerebral palsy
A clinical study finally shows that CBN does indeed help with sleep
Big review finds CBD does not cause cognitive impairment
First good clinical tests on THCV
Moving case report of cannabis helping someone with the searing neuropathic pain of Fabry disease
Plus, CBD’s help for Angelman syndrome
Melatonin receptors pair up with CB1 receptors (also with the adenosine receptors of caffeine)
Data from a reproduction conference confirm that THC exposure is just lousy for reproductive success
And in pregnant mothers, smoking before the pregnancy was associated with more first-trimester morning sicknessResults from the Chest 2023 conference have a whole lotta negative cannabis case reports
Can you rely on postmortem cannabinoid concentrations?
A big week for cannabinoid chemistry tools
Hemp foods for vegetarians
A request to spread the word
This newsletter only spreads by word of mouth,
so please forward to colleagues & tell your friends & relatives.
Sponsor: PlusCBD is top of the industry!
I’m going to let this week’s TikTok about the new industry sales data speak for itself…
(but better watch it now before SPINS makes me take it down for sharing insider info)
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My work this week:
Canna-Education for CV Sciences
(TikTok:@cvsciences or my YouTube playlist 3-minute Cannabinoid Science):
CBD's Crazy Binding (proud of this one. got it all done in 3 minutes on the first take)
GABA, CBD & Calming the Brain (surprise appearance by my firstborn)
Cerebral Palsy & the Cannabinoids
CBD & Bone Growth
ADHD & the Cannabinoids
Spirituality:
Cannabis & Spirituality (20k views)
Cannabis & Spirituality: A Book & Advice
Cannabis in India's History
The Sufis & Cannabis
My TikToks (@lexpelgerandhisbooks or on YouTube):
My kid's first BookTok: The Owl & the Pussycat (nice work Sofia! Appreciate the cannabis shoutout…)
The Quantum Weirdness of the Double Slit Experiment (just released this but have a feeling it will blow up) (it did)
My sexy storytelling (13’)
Hermeticism, hermeticism, hermeticism…
Number 3 on the Hermetic Memory Wall
Number 6 on the Hermetic Memory Wall
Bruno's Response to his Death Sentence
Books, books, books…
A stack of great kids books: Dinos, Myths & More
Walter Benjamin's 'One-Way Street'
Benjamin on the Marseilles Religion Station
Blake, Blake, Blake…
'William Blake vs the World' by John Higgs
Blake's 'The Fly'
Blake's 'The Garden of Love'
Blake's 'The Human Abstract'
Blake's 'A Divine Image'
My platforms: Linktree
YouTube for educational videos, lectures & shorts on new cannabinoid science
Anandamide; or, the People: my graphic novel series on cannabis, the endocannabinoid system & the War on Drugs based on Moby-Dick
My podcasts
LinkedIn , Facebook, Twitter & my TikTok on books, hermeticism, science & history
Ways to support this work:
Subscribe on Substack
Buy Me a Coffee
Venmo: @Lex-Pelger
PayPal: donate here
Best Of Cannabinoid Science...
What is the strongest cannabinoid?
https://marijuanaindex.com/articles/strongest-cannabinoid/
(if this isn’t the most clicked on article this week according to my stats, I’ll be surprised)
An interview on using CBD & THC for dogs
Exploring the potential of CBD-based therapies in dogs
https://analyticalscience.wiley.com/content/article-do/exploring-potential-cbd-based-therapies-dogs
Clinical
For cerebral palsy, a survey of doctors finds strong support on using cannabinoids for the epilepsy, spasticity & pain
Prescription Practices of Cannabinoids in Children with Cere-bral Palsy Worldwide - A Survey of the Swiss Cerebral Palsy Registry
https://www.preprints.org/manuscript/202310.0080/v1
Of course this data comes out a day after I make a video on cerebral palsy bemoaning the lack of data.
A survey of why people are using CBD listed neurological disorders, pulmonary conditions, gastrointestinal disorders & chronic pain
Consumer perception, knowledge, and uses of cannabidiol
https://meridian.allenpress.com/mhc/article/13/5/217/496172
A double-blind placebo sleep study finds CBN to be helpful for improving overall sleep disturbance
A Double-Blind, Randomized, Placebo-Controlled Study of the Safety and Effects of CBN With and Without CBD on Sleep Quality
https://psycnet.apa.org/fulltext/2024-14146-001.pdf
In older adults, medical cannabis use was not associated with a decrease in daily living activities
Medical Cannabis Is Not Associated with a Decrease in Activities of Daily Living in Older Adults
https://www.mdpi.com/2227-9059/11/10/2697
A clinical test on the range of effects from doses of THCV
A Two-Phase, Dose-Ranging, Placebo-Controlled Study of the Safety and Preliminary Test of Acute Effects of Oral Δ8-Tetrahydrocannabivarin in Healthy Participants
https://pubmed.ncbi.nlm.nih.gov/37721990/
Most notably, the most common adverse event was euphoria (<eye roll>) & it's possible to test positive on a urine screen for THC after ingesting THCV.
Notably, THCV plants are apparently coming back in the California market.
A chart review on the efficacy of cannabis for anxiety & depression
Physician-Guided Medical Cannabis Treatment for Comorbid Anxiety and Depression Disorders in a Canadian Multidisciplinary Clinic: A Retrospective Review
https://www.endocannabinoidmedicine.com/academicarticle/physician-guided-medical-cannabis-treatment-for-comorbid-anxiety-and-depression-disorders-in-a-canadian-multidisciplinary-clinic-a-retrospective-review/
A personal case report on using cannabis for anxiety
An Individual's Lived Experiences of Taking Cannabis-Based Medicinal Products (CBMPs) to Treat Anxiety
https://pubmed.ncbi.nlm.nih.gov/37754635/
In a survey, caregivers endorsed CBD as helpful for Angelman syndrome (a genetic disorder that leads to developmental delays as well as happy, excitable personalities)
Quality of Life in Angelman Syndrome: A Caregivers' Survey
https://pubmed.ncbi.nlm.nih.gov/37757661/
In a case report of a person with Fabry disease (a genetic neurological disorder that causes pain & a variety of symptoms), cannabis helped to relieve their nocturnal neuropathic pain when nothing else would
Relief of nocturnal neuropathic pain with the use of cannabis in a patient with Fabry disease
https://www.sciencedirect.com/science/article/pii/S2214426923000563
In adults with drug-resistant epilepsies, the safety & efficacy of CBD
High-purified cannabidiol efficacy and safety in a cohort of adult patients with various types of drug-resistant epilepsies
https://pubmed.ncbi.nlm.nih.gov/37806886/
In a pregnancy study really looking hard for harms but not finding them, pregnant women who use cannabis had no significant differences in their prefrontal cortex response to infant cues like crying
Cannabis use during pregnancy and hemodynamic responses to infant cues in pregnancy: an exploratory study
https://pubmed.ncbi.nlm.nih.gov/37743996/
But brain scan data from a cohort of children found prenatal cannabis exposure to be linked to lower levels of white matter in the frontolimbic pathways (key for emotion & memory processes)
The First “Hit” to the Endocannabinoid System? Associations Between Prenatal Cannabis Exposure and Frontolimbic White Matter Pathways in Children
https://www.sciencedirect.com/science/article/pii/S2667174323001350
Sexual minorities are more likely to be vaping cannabis
Recency of Cannabis Vaping in Sexual Minorities in Wave 5 of the Population Assessment of Tobacco and Health (PATH) Study
https://pubmed.ncbi.nlm.nih.gov/37750356/
Cool kids gotta cool.
In dogs with osteoarthritis, an analysis of the endocannabinoid system at their joints indicates a therapeutic use for cannabinoid medicines
Endocannabinoid System Receptors at the Hip and Stifle Joints of Middle-Aged Dogs: A Novel Target for the Therapeutic Use of Cannabis sativa Extract in Canine Arthropathies
https://pubmed.ncbi.nlm.nih.gov/37760233/
Reviews
A nice historical review of cannabis over the last 12,000 years
Cannabis: 12,000 years of experiences and prejudices
https://www.scielo.br/j/brjp/a/Z47fDGfxC9SwpbpwVPDBcWR/
A big review of 59 studies on CBD & cognition find no impairment
Effects of the Acute and Chronic Administration of Cannabidiol on Cognition in Humans and Animals: A Systematic Review
https://www.liebertpub.com/doi/abs/10.1089/can.2023.0086
A collection of the data on CBD & inflammation
Effects of Cannabidiol in Inflammation: A Review of Pre-clinical and Clinical Findings
https://pubmed.ncbi.nlm.nih.gov/37736946/
And a review of how acupuncture may be helping with inflammation & organ damage in sepsis via the endocannabinoid system
Revealing the biological mechanism of acupuncture in alleviating excessive inflammatory responses and organ damage in sepsis: a systematic review
https://pubmed.ncbi.nlm.nih.gov/37753078/
A review of the little known on the interplay between cannabis, endometriosis & the gut microbiome
Cannabis and Endometriosis: The roles of the gut microbiota and the endocannabinoid system
https://www.preprints.org/manuscript/202310.0234/v2
On cannabinoids for kidney & liver toxicity
Cannabinoids as Potential Therapeutic Agents for Kidney and Liver Toxicity
https://journals.ekb.eg/article_319056_c86b5a72e96ad3102413426b637cc48d.pdf
A review of the pediatric use of medical cannabis
Pediatric patients and medical cannabis: new trends
https://www.scielo.br/j/brjp/a/qVFkCw8LKzRb5tkjL7BtHWk/
A review of the antibacterial properties of the cannabinoids by friend of the newsletter Aleksi Hupli
Potential Antibacterial Application of Cannabinoids: A Narrative Review of Preclinical Studies
https://www.endocannabinoidmedicine.com/academicarticle/potential-antibacterial-application-of-cannabinoids-a-narrative-review-of-preclinical-studies/
A review of the most common contaminants in cannabis
Fungal and mycotoxin contaminants in cannabis and hemp flowers: implications for consumer health and directions for further research
https://www.frontiersin.org/articles/10.3389/fmicb.2023.1278189/full
An analysis of the EU’s public health data on serious adverse events from unlicensed CBD
Pharmacovigilance of unlicensed cannabidiol in European countries
https://onlinelibrary.wiley.com/doi/pdf/10.1002/ptr.8028
On how exercise interacts with your endocannabinoid system & kynurenine pathway as well as the potential relevance for depression & obesity
Crosstalk between Exercise-Derived Endocannabinoidome and Kynurenines: Potential Target Therapies for Obesity and Depression Symptoms
https://pubmed.ncbi.nlm.nih.gov/37895892/
For you neurochem nerds, how cannabinoid receptors form heterodimers with an adenosine receptor (a neurotransmitter that modulates the release of other neurotransmitters as well as synaptic plasticity & neuroprotection)
The adenosine A2A receptor in the basal ganglia: Expression, heteromerization, functional selectivity and signalling
https://pubmed.ncbi.nlm.nih.gov/37741696/
Preclinical
In a mouse model of obesity, five weeks of THC lessened weight gain & improved their glucose tolerance while five weeks of CBD increased lipid metabolism in fat & liver tissues as well as improving glucose tolerance
The Effect of Orally Administered Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) on Obesity Parameters in Mice
https://pubmed.ncbi.nlm.nih.gov/37762099/
In human microglial cells (white blood cells that eat invaders), the anti-inflammatory effects of the minor cannabinoids
Anti-Inflammatory Effects of Minor Cannabinoids CBC, THCV, and CBN in Human Macrophages
https://pubmed.ncbi.nlm.nih.gov/37764262/
And they engineered a mouse to have no CB2 receptors on their microglial cells & analyzed the effects
In Vivo Validation of an Inducible Microglial Cannabinoid Receptor 2 Knockout Mouse
https://www.mq.edu.au/__data/assets/pdf_file/0007/1275217/MNM-Abstract-Book-2023_Final1.pdf#page=61
An analysis of the data around the dual hit model of schizophrenia: prenatal cannabis exposure + adolescent cannabis use = adult schizophrenia
Prenatal risk factors and postnatal cannabis exposure: Assessing dual models of schizophrenia-like rodents
https://pubmed.ncbi.nlm.nih.gov/37783300/
In mice, the terpene beta caryophyllene caused allergic skin reactions while CBD displayed no allergic response
Epicutaneous Sensitization to the Phytocannabinoid β-Caryophyllene Induces Pruritic Inflammation
https://pubmed.ncbi.nlm.nih.gov/37762646/
An analysis of variants of the FAAH gene found that lower FAAH activity was associated with more anandamide & less well-being scores as well as an association with alcohol dependence
Functional Variation in the FAAH Gene Is Directly Associated with Subjective Well-Being and Indirectly Associated with Problematic Alcohol Use
https://pubmed.ncbi.nlm.nih.gov/37761966/
Biochem sexiness: how the melatonin receptors & the CB1 receptors form heteromer complexes (picture it as co-habitation. They move in together, get a joint bank account, probably adopt a dog, and start doing some things completely differently than they do on their own)
SAT025 Characterization Of The Melatonin Type 1 Receptor / Cannabinoid Type 1 Receptor (MT1/CB1) Heteromers
https://academic.oup.com/jes/article/7/Supplement_1/bvad114.1374/7290074
An evergreen note on reading restricted papers:
First stop for seeing if there’s a free version of a paper, use the Google Scholar Chrome extension (Mac version), Google Scholar itself or try ResearchGate.
Three other helpful browser extensions are: Unpaywall, Open Access Button & PaperPanda
For the infamous backdoor, use Sci-Hub – the pirated papers repository (Chrome extension here). This works better for older paper than the stuff that just came out.
Finally, email the author. They’re almost always happy to oblige because, thanks to the predatory academic publishing system, they don’t make a dollar off of their papers.
the Headlines & Fav Articles
Wow. Hemp derived cannabinoids sales was larger than all the state cannabis sales combined, roughly similar to craft beer
https://www.marijuanamoment.net/sales-of-hemp-derived-cannabinoids-like-cbd-outpace-legal-marijuana-and-are-on-par-with-craft-beer-report-finds/
Michigan to allow cannabis commerce with tribal businesses
https://www.marijuanamoment.net/michigan-governor-signs-bills-allowing-marijuana-commerce-with-tribal-businesses/
And a deep dive on the problems of the Eastern Cherokee who were poised for an early start in the North Carolina cannabis industry as well as the history of Native Americans with medical cannabis & the paternalistic federal government
https://www.truthdig.com/articles/jackpot-denied-cannabis-casinos-and-the-limits-of-tribal-sovereignty/
Friend of the newsletter Mary Jane Oatman talks her memory of her grandparents, traditional healers, being arrested in the ‘80s by BIA agents for growing cannabis on tribal land.
The DEA agent fired for a positive THC test caused by a CBD product started a GoFundMe to cover his legal fees as he sues the agency
https://www.marijuanamoment.net/former-dea-agent-fired-over-positive-thc-test-from-cbd-products-solicits-public-support-as-legal-fees-mount-to-challenge-agencys-action/
Meanwhile, the agency will be vastly boosting the allowed supply of THC & other cannabinoids for scientific research
https://www.marijuanamoment.net/dea-wants-nearly-1-million-grams-of-delta-9-thc-manufactured-for-research-next-year-in-latest-schedule-i-quota-hike/
In states that have legalized cannabis, home values have gone up significantly higher (41%)
https://www.marijuanamoment.net/home-values-have-increased-significantly-more-in-states-that-legalized-marijuana-than-those-that-kept-criminalization-real-estate-study-finds/
International
Malta finally issues its first two licenses to nonprofit cannabis associations to begin growing their cannabis, a first in the EU
https://www.marijuanamoment.net/malta-issues-eus-first-licenses-allowing-nonprofit-cannabis-associations-to-begin-growing-marijuana/
Ireland opens its first medical cannabis business
https://www.prnewswire.co.uk/news-releases/irelands-first-medicinal-cannabis-clinic-medicann-is-now-open-for-patients-301974796.html
New Zealand moved CBD down from “prescription only” (doctor visit) to “restricted” (available from a pharmacist)
https://www.medsafe.govt.nz/profs/class/ReclassificationOfLowDoseCannabidiol.asp
An analysis of Australia’s medical cannabis program
A provisional evaluation of Australia's medical cannabis program
https://pubmed.ncbi.nlm.nih.gov/37813082/
And in the UK, the challenges of being a medical cannabis patient
"It's a big added stress on top of being so ill": The challenges facing people prescribed cannabis in the UK
https://pubmed.ncbi.nlm.nih.gov/37806073/
In Africa, six interviews with doctors & pharmacists about their perceptions & concerns about medical cannabis
Medicinal use of cannabis: A qualitative study of the perspectives of doctors and pharmacists from six African countries
https://pubmed.ncbi.nlm.nih.gov/37791493/
And an analysis of THC & CBD content in Togo
Determination of tetrahydrocannabinol and cannabidiol contents in Cannabis sativa L. samples in Togo using gas chromatography-mass spectrometry
https://academicjournals.org/journal/JMPR/article-full-text-pdf/8A05BC871326.pdf
In Ecuador, interviews & analysis of the cannabis regulatory regimes
Morality, Wholesomeness, and Consumption. Cannabis Regulatory Regimes in Ecuador
https://www.preprints.org/manuscript/202309.1958/v1
The War on Drugs & the End of Prohibition
Sad to see a raid of the Drug Liberation Front, the Canadian harm reduction org that had been handing out safe testws drugs to combat the poisoned drug supply that is decimating Vancouver
https://www.cbc.ca/news/canada/british-columbia/dulf-support-rally-vancouver-1.7018662
FBI says at least a quarter million people arrested for cannabis last year
https://cannabislaw.report/at-least-a-quarter-of-a-million-people-were-arrested-for-cannabis-last-year-fbi-announces/
#EndThisFuckingDrugWarNow
On delta-8 THC, 24 states have either banned or severely restricted sales
https://www.greenmarketreport.com/delta-8-legality-a-national-patchwork-of-irony/
In Colorado & Washington, cannabis legalization had little effects on the disparity between Black & White prison incarceration rates
Marijuana legalization and racial disparities in prison incarceration in Colorado and Washington State: a quasi-experimental study
https://link.springer.com/article/10.1007/s11292-023-09590-w
How California tests you for DUIs
https://www.sacbee.com/news/california/article280457749.html
In French drivers, cannabis was the most frequently detected illegal psychoactive
Trends in drivers testing positive for drugs of abuse in oral fluid from 2018 to 2021 in France
https://pubmed.ncbi.nlm.nih.gov/37748427/
On how young people feel about riding with a cannabis-impaired driver
Longitudinal perspectives of riding with a cannabis-impaired driver
https://pubmed.ncbi.nlm.nih.gov/37717297/
Business & Law
An analysis of Canada’s cannabis tourism
Motivations, risks, and constraints: An analysis of affective and cognitive images for cannabis tourism in Canada
https://www.sciencedirect.com/science/article/pii/S2666957923000253
A cost-benefit analysis of legalizing cannabis by the Federal Reserve Bank of Kansas City
Economic Benefits and Social Costs of Legalizing Recreational Marijuana
https://www.kansascityfed.org/Research%20Working%20Papers/documents/9825/rwp23-10browncohenfelix.pdf
Psychedelics, Plant Medicines & Other Psychoactives
Shalya Love continues to be one of the best drug writers out there as she covers her experience with the psilocybin retreat Synthesis & asks the questions about what these retreats are supposed to be & what should they have
I Went to a High-End Psychedelic Retreat to Address My Anxiety
https://www.vice.com/en/article/n7jeeg/i-went-to-a-high-end-psychedelic-retreat-to-address-my-anxiety
I was surprised to learn she hadn’t taken drugs since her early 20s – but it goes to show that you can still be a great drug journalist & not be getting twisted every weekend.
Kratom showing up at kava bars
https://www.bloomberg.com/news/newsletters/2023-10-23/kratom-a-dea-drug-of-concern-is-driving-growth-at-kava-bars
On the weirdness of the mandrake root
The Murderous (And Magical) Mandrake Root
The Psychoactive Research
[This isn’t a deep dive into the science of psychedelics & other psychoactives like I do for the cannabinoids. If your organization would be interested in a breakdown of all the new psychedelic science, reach out to me]
On the role of the ego in psychedelic drugs
The ego in psychedelic drug action - ego defenses, ego boundaries, and the therapeutic role of regression
https://pubmed.ncbi.nlm.nih.gov/37869510/
In treating depression with IV ketamine, the factors associated with positive effects
Factors Associated with Antidepressant Effects of Ketamine: A Reanalysis of Double-Blind Randomized Placebo-Controlled Trial of Intravenous Ketamine for Treatment-Resistant Depression
https://pubmed.ncbi.nlm.nih.gov/37846462/
On combining psilocybin with neurofeedback
Psilocybin-assisted neurofeedback for the improvement of executive functions: a semi-naturalistic-lab feasibility study
https://osf.io/preprints/psyarxiv/jqasf/
A review of the mechanisms of psychedelics
Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics
https://pubmed.ncbi.nlm.nih.gov/37759040/
For brain imaging, a review of the results & limitations of studying these psychoactives
Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA: Methodological limitations and convergent results
https://pubmed.ncbi.nlm.nih.gov/37802267/
And a look at the future
Neuroimaging in psychedelic drug development: past, present, and future
https://pubmed.ncbi.nlm.nih.gov/37759038/
In mice, the brain changes from microdoses of psilocybin
Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats
https://pubmed.ncbi.nlm.nih.gov/37783788/
The Plant & the History
Growing & Farming
CBD as a defense against aphids
Assessing the adaptive role of cannabidiol (CBD) in Cannabis sativa defense against cannabis aphids
https://www.frontiersin.org/articles/10.3389/fpls.2023.1223894/full
Using genetic markers to differentiate drug-type & fiber-type cannabis
A forensic application of genetic markers for distinction between drug-type and fiber-type Cannabis sativa L
https://pubmed.ncbi.nlm.nih.gov/37863007/
Cloning cannabis with cuttings & auxin
Propagation of Cannabis sativa (L.) plants through cuttings and use of auxin phytoregulators
https://revistas.uptc.edu.co/index.php/ciencias_horticolas/article/view/16428
Improving cannabis tissue cultures with 2-aminoindane-2-phosphonic acid (AIP)
2-aminoindane-2-phosphonic acid (AIP) improves Cannabis sativa protoplast isolation and early cellular division
https://www.preprints.org/manuscript/202309.2141/v1
A reference genome of seed hemp
The reference genome of seed hemp (Cannabis sativa) provides new insights into fatty acid and vitamin E synthesis
https://pubmed.ncbi.nlm.nih.gov/37717143/
The best treatments for the grey mold Botrytis cinerea Pers.
Using Detached Industrial Hemp Leaf Inoculation Assays to Screen for Varietal Susceptibility and Product Efficacy on Botrytis cinerea
https://pubmed.ncbi.nlm.nih.gov/37765441/
On a crinivirus that causes yellow leaves
Cucurbit chlorotic yellows virus, a crinivirus infecting Cannabis sativa plants
https://bsppjournals.onlinelibrary.wiley.com/doi/full/10.1111/ppa.13800
A cannabis gene that may increase susceptibility to powdery mildew
Genetic mapping, identification, and characterization of a candidate susceptibility gene for powdery mildew in Cannabis sativa L
https://pubmed.ncbi.nlm.nih.gov/37750850/
A well-done thesis project on the genetic underpinnings to hemp cultivar performance
Elucidating the Genetic Basis of Cultivar Performance and Biotic Interactions in Hemp
https://www.proquest.com/openview/00ff0d02717ed1f2cfee3cbcf9269d71/1?pq-origsite=gscholar&cbl=18750&diss=y
On the cytotoxicity of hemp essential oils as nanoemulsions
Encapsulation of Hemp ( Cannabis sativa L.) Essential Oils into Nanoemulsions for Potential Therapeutic Applications: Assessment of Cytotoxicological Profiles
https://pubmed.ncbi.nlm.nih.gov/37764255/
Hemp as food
A review of hemp as a functional food for vegetarians
The Role of Hemp ( Cannabis sativa L.) as a Functional Food in Vegetarian Nutrition
https://pubmed.ncbi.nlm.nih.gov/37761214/
An analysis of the contents of hemp seeds
Vitamin E, Phytosterol, and Carotenoid Contents of Hemp (Cannabis sativa L.) Seed
https://www.e-jkfn.org/journal/view.html?doi=10.3746/jkfn.2023.52.9.975
Using hemp proteins to lower freezer burn (I think is what they’re saying)
Hemp protein hydrolysates’ ability to inhibit ice recrystallization is influenced by the dispersing medium and succinylation
https://www.sciencedirect.com/science/article/abs/pii/S0268005X23009219
Horses seem to like hempseed meal pellets
Assessment of the Palatability and Acceptability of Hempseed Meal Pellets in Horses Compared to Mainstream Feedstuffs
https://pubmed.ncbi.nlm.nih.gov/37726036/
Industrial Use
Hemp based e-textiles
Hemp-Based Electronic Textiles for Sustainable and Wearable Applications
https://pubs.acs.org/doi/abs/10.1021/acssuschemeng.3c02579
Thermal behavior of a hemp-earth house
Assessment of the thermal behavior of two houses built with wood or hemp-earth blocks
https://pubs.aip.org/aip/acp/article-abstract/2761/1/020005/2914890/Assessment-of-the-thermal-behavior-of-two-houses?redirectedFrom=fulltext
CANNABINOID SCIENCE
A review of the history & chemistry of cannabis
From ancient Asian relics to contemporaneity: A review of historical and chemical aspects of Cannabis
https://www.eurjchem.com/index.php/eurjchem/article/view/2442
A review with nice charts of the many uses of cannabis
A review of the industrial use and global sustainability of Cannabis sativa
https://www.researchgate.net/publication/374381925_A_review_of_the_industrial_use_and_global_sustainability_of_Cannabis_sativa
A review of the abuse of cannabis that seems like it's from the 1950s
Cannabis and Other Substance Misuse: Implications and Regulations
https://pubmed.ncbi.nlm.nih.gov/37755766/
Clinical Use, Surveys & Ingestions Methods
In Canada, the reasons that 100k+ went to the hospital because of cannabis over the last seven years
Changes in Cannabis-Attributable Hospitalizations Following Nonmedical Cannabis Legalization in Canada
https://pubmed.ncbi.nlm.nih.gov/37796504/
Military veterans continue to use a lot of cannabis (too bad the VA is such a dinosaur about their medicine)
Prevalence and Correlates of Cannabis Use among U.S. Veterans during the Second Wave of the COVID-19 Pandemic
https://pubmed.ncbi.nlm.nih.gov/37715685/
Can you rely on postmortem cannabinoid concentrations?
Are Postmortem Cannabinoid Concentrations Forensically Reliable?
https://pubmed.ncbi.nlm.nih.gov/37801547/
In postmortem cases, using fluids from the chest cavity to look for cannabinoid metabolites
11-Nor-9-Carboxy Tetrahydrocannabinol Distribution in Fluid from the Chest Cavity in Cannabis-Related Post-Mortem Cases
https://pubmed.ncbi.nlm.nih.gov/37755750/
On finding the best ways in surveys to measure cannabis consumption quantities
Exploring survey methods for measuring consumption quantities of cannabis flower and concentrate products
https://pubmed.ncbi.nlm.nih.gov/37774316/
Adolescents & Young People
In young people, those who began using cannabis or tobacco at an earlier age are more likely to display later depressive symptoms
Depressive symptoms and the age of initiation of tobacco and marijuana use among adolescents and young adults
https://pubmed.ncbi.nlm.nih.gov/37757647/
Of course, this does not equate to causality. An equally valid guess is that those young people were using these to medicate their first deep adolescent pangs of depression. I know I did.
Among young adults in Washington, cannabis legalization was associated with a sharp increase in usage by females as well as increased cannabis use disorder
Changes in Cannabis Use From 2014 to 2019 Among Young Adults in Washington State
https://www.sciencedirect.com/science/article/abs/pii/S0749379723003884
And in high risk young adults, cannabis legalization did not particularly change their usage & and per normal, they aged out of using it as they got older
Cannabis Use Frequency and Cannabis-Related Consequences in High-Risk Young Adults Across Cannabis Legalization
https://pubmed.ncbi.nlm.nih.gov/37755827/
A study of survey data found an association with legalization’s increase of young adult depression & cannabis use
Young Adult Depression and Cannabis Use: Associations Before and After Recreational Legalization
https://pubmed.ncbi.nlm.nih.gov/37778528/
In young adults, anxiety is a predictor of the age of initiation of cannabis & tobacco use
Anxiety as a predictor of the age of initiation of tobacco and cannabis use in adolescents and young adults
https://www.sciencedirect.com/science/article/abs/pii/S030646032300271X
On adolescents with multiple suicide attempts & their use of prescription opioids & cannabis
Investigating the co-occurrence of marijuana use and prescription opioid misuse with multiple suicide attempts among adolescents with a history of suicidal ideation
https://pubmed.ncbi.nlm.nih.gov/37816289/
Different parental practices & their associations with the use of alcohol & cannabis by their adolescents
Parental practices and their association with alcohol and cannabis use among adolescents in Chile
https://pubmed.ncbi.nlm.nih.gov/37767214/
In adolescent rats exposed to THC vapor, as adults they were less inclined to use nicotine or to experience the temperature changing effects of THC
Adult consequences of repeated nicotine and Δ 9 -tetrahydrocannabinol (THC) vapor inhalation in adolescent rats
https://pubmed.ncbi.nlm.nih.gov/37745433/
Neurology & Brain Diseases
An analysis of how CBD enters the rat’s brain in different time periods of its life
Entry of cannabidiol into the fetal, postnatal and adult rat brain
https://assets.researchsquare.com/files/rs-3409156/v1_covered_6d423b64-4aeb-4ea6-ac5f-823cf1423253.pdf
In a rat model of Alzheimer's disease, the CB1 receptors seemed to be therapeutic targets against memory loss & cognitive decline
Memory impairment was ameliorated by corticolimbic microinjections of arachidonylcyclopropylamide (ACPA) and miRNA-regulated lentiviral particles in a streptozotocin-induced Alzheimer's rat model
https://pubmed.ncbi.nlm.nih.gov/37783412/
Different versions of the Sgip1 protein did not show differences in their ability to inhibit the internalization of CB1 receptors (pull them back into the cell for recycling)
Multiple Sgip1 splice variants inhibit cannabinoid receptor 1 internalization
https://pubmed.ncbi.nlm.nih.gov/37783296/
Mental Health & Substance Use Disorders
For mental health nurses, how to practice harm reduction around adult use cannabis
Recreational cannabis policy reform-What mental health nurses need to know about minimising harm and contributing to the reform debate
https://pubmed.ncbi.nlm.nih.gov/37767750/
In people living with HIV, their cannabis use did not seem linked to worsening hippocampal memory function
HIV chronicity as a predictor of hippocampal memory deficits in daily cannabis users living with HIV
https://pubmed.ncbi.nlm.nih.gov/37736522/
For people with cannabis use disorder going through withdrawal, the sleep medication zolpidem helped with the sleep disturbances
Randomized controlled trial of zolpidem as a pharmacotherapy for cannabis use disorder
https://pubmed.ncbi.nlm.nih.gov/37802317/
On potential solutions to lowering the stigmas of using cannabis for harm reduction with substance use disorders
Stigma-related barriers to medical cannabis as harm reduction for substance use disorder: Obstacles and opportunities for improvement
https://pubmed.ncbi.nlm.nih.gov/37767954/
A strange little study of engineering students found cannabis use linked to narcissistic personality disorder
Frequency of Narcissistic Personality Disorder in Cannabis Consumer Engineering Students
https://www.sciencedirect.com/science/article/abs/pii/S0034745023000847
In rats & mice, they have GPR55 receptors (which may one day be known as the CB3 receptors) on their neurons that produce glutamate (the brain's primary excitatory neurotransmitter ) & these modulates their intake & seeking of nicotine
GPR55 is expressed in glutamate neurons and functionally modulates nicotine taking and seeking in rats and mice
https://assets.researchsquare.com/files/rs-3222344/v1/75d75931-c501-4938-9ade-d508e9702215.pdf?c=1696357301
Pain, Inflammation & Surgeries
In people undergoing surgery for a broken wrist, cannabis use was associated with an elevated risk of infection & poor union of the broken parts
Cannabis Use in Patients With Distal Radius Fractures: A Moment of Unity?
https://journals.sagepub.com/doi/abs/10.1177/15589447231196905
On the impact of cannabis use on outpatient anesthesia
What does the preliminary data tell us about the impact of recreational marijuana use on outpatient sedation?
https://pubmed.ncbi.nlm.nih.gov/37739914/
And another one that I can’t even see the abstract of
Marijuana Use, Vaping, and Preoperative Anesthetic and Surgical Considerations in Clinical Practice
https://www.anesthesiology.theclinics.com/article/S1932-2275(23)00088-5/fulltext
A review of the practical aspects of using cannabis for pain
Practical aspects of the use of medicinal cannabis in chronic pain
https://www.scielo.br/j/brjp/a/TXvkhy7kZ4gHqVXtbkYb8Vc/
In a mouse model of sepsis from pneumonia, activating the CB2 receptor lowered local & systemic inflammation
Cannabinoid CB2 receptor agonist reduces local and systemic inflammation associated with pneumonia-induced sepsis in mice
https://pubmed.ncbi.nlm.nih.gov/37797676/
In a rat spinal cord, the endocannabinoids are involved in the effects of lowering pain
Involvement of cannabinoid receptors in depression of the putative nociceptive response in spinal cord preparations isolated from neonatal rats
https://pubmed.ncbi.nlm.nih.gov/37803279/
And here’s an analysis of where the CB1 receptors are located in the male & female rat spinal cord
Cannabinoid CB1 receptor expression and localization in the dorsal horn of male and female rat and human spinal cord
https://www.tandfonline.com/doi/pdf/10.1080/24740527.2023.2264895
In tilapia fish, CBD lowered stress biomarkers
Effects of CBD (Cannabidiol) on the physiology of Nile tilapia (Oreochromisn niloticus) as a chronic stress mitigating agent In-vivo
https://pubmed.ncbi.nlm.nih.gov/37713426/
Leaf & flower extracts of hemp possessed antioxidant & neuroprotective properties
The Antioxidant and Neuroprotective Potential of Leaves and Inflorescences Extracts of Selected Hemp Varieties Obtained with scCO2
https://pubmed.ncbi.nlm.nih.gov/37891906/
In a new hemp cultivar called Pink Pepper, the CBD from it has anti-inflammatory effects
In Vitro and In Vivo Anti-Inflammatory Effects of Cannabidiol Isolated from Novel Hemp ( Cannabis sativa L.) Cultivar Pink Pepper
https://pubmed.ncbi.nlm.nih.gov/37764215/
New CBD derivatives that have antioxidant effects
Pharmacological Evaluation of Newly Synthesized Cannabidiol Derivates on H9c2 Cells
https://pubmed.ncbi.nlm.nih.gov/37760017/
Female-specific, Reproduction & Hormones
In pregnant mothers, using cannabis in the three months before pregnancy was associated with more first-trimester morning sickness severity
Nausea and vomiting of pregnancy and prenatal cannabis use in a Michigan sample
https://www.sciencedirect.com/science/article/abs/pii/S2589933323003130
In pregnant women, cannabis exposure was linked to smaller birth weight & cranial size
The impact of in utero cannabis exposure on fetal growth
https://pubmed.ncbi.nlm.nih.gov/37718860/
An analysis of placentas finds that they store CBD, slowing down distribution to the fetus but also prolonging fetal CBD levels
Placental disposition of cannabidiol: An ex vivo perfusion study
https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.17778
In a survey of pregnant & breastfeeding mothers, those using cannabis for mental health concerns usually weren’t taking other psychiatric medications
Psychiatric medication use among pregnant and breastfeeding mothers who used cannabis for mental health concerns: A cross-sectional survey study
https://pubmed.ncbi.nlm.nih.gov/37746858/
In pregnant mice with seizures from eclampsia, higher levels of CB1 receptors in the hippocampus protected mice from worse seizure outcomes
Increased hippocampal cannabinoid 1 receptor expression is associated with protection from severe seizures in pregnant mice with reduced uterine perfusion pressure
https://pubmed.ncbi.nlm.nih.gov/37772463/
In human Leydig cells (producers of testosterone), CBD inhibited their growth & caused adverse effects
Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
https://pubmed.ncbi.nlm.nih.gov/37794255/
A thesis project in pregnant mice showed exposure to cannabis smoke altered genetic transcription & gut-brain axis development
IMPACT OF FETAL CANNABINOID EXPOSURE ON GUT-BRAIN AXIS DEVELOPMENT
https://macsphere.mcmaster.ca/handle/11375/28971
In zebrafish embryos, CBD mitigated the developmental toxicity & behavioral impairments of the epilepsy treatment valproic acid
Cannabidiol Mitigates Valproic Acid-Induced Developmental Toxicity and Locomotor Behavioral Impairment in Zebrafish
https://www.researchgate.net/publication/374234062_Cannabidiol_Mitigates_Valproic_Acid-Induced_Developmental_Toxicity_and_Locomotor_Behavioral_Impairment_in_Zebrafish
79th Scientific Congress of the American Society for Reproductive Medicine
In a survey of males submitting their semen for analysis, as their fertility journey continued, they tended to use less cannabis & tobacco but not alcohol
MARIJUANA, TESTOSTERONE AND ALCOHOL USE IN INDIVIDUALS SUBMITTING FELLOWTM MAIL-IN SEMEN ANALYSES: UTILIZING USER-REPORTED SURVEY DATA TO DESCRIBE CONTEMPORARY BEHAVIOR OF FERTILITY PATIENTS
https://www.fertstert.org/article/S0015-0282(23)01471-1/fulltext
In the sperm of rhesus macaques, THC exposure turned off 55 important genes related to male fertility
DELTA-9-TETRAHYDROCANNABINOL EXPOSURE ALTERS SPERM DNA METHYLATION IN RHESUS MACAQUES
https://www.fertstert.org/article/S0015-0282(23)01171-8/fulltext
In cells important to the placenta & embryo development process, high THC exposure caused a number of negative events
HIGH RISK, LOW REWARD: CANNABIS TREATMENT INDUCES MULTIPARAMETRIC DYSFUNCTION IN HUMAN ENDOMETRIAL AND TROPHOBLAST CELLS WITH COMPLEX IMPLICATIONS FOR PLACENTATION AND FUTURE FERTILITY
https://www.fertstert.org/article/S0015-0282(23)01029-4/fulltext
“We demonstrated the pleotropic and detrimental consequences of repeated, high THC exposure on the “black box” events at the human maternal-fetal interface. Notably, THC diminished EC decidualization, robustly increased oxidative stress and induced senescence. THC perturbed TB-lineage differentiation, enhanced mitochondrial dysfunction and disrupted cell cycle control in the presence of high ROS. Together, these may dysregulate endometrial-trophoblast crosstalk, promote premature uterine aging and development of genetic abnormalities, leading to implantation failure.”
In a study of the effect of THC on human eggs, they found that it changed the expression of many genes
IN-VITRO TREATMENT OF HUMAN OOCYTES WITH CANNABIS ALTERS GENES INVOLVED IN CHROMOSOMAL ORGANIZATION AND SEGREGATION - A SINGLE CELL RNASEQ STUDY
https://www.fertstert.org/article/S0015-0282(23)01030-0/fulltext
“Of oocytes that matured to metaphase-II, there were 189 differentially expressed genes (DEGs) in THC1 vs Ctrl; 66 genes were upregulated, and pathway analysis revealed an enrichment in mitochondrial respiration and response to toxic substances. The 123 downregulated genes were associated with regulation of chromosome segregation and duplication and cell development. Furthermore, 6 genes previously associated with oocyte maturation were differentially expressed (ACTG1, ANK2, PWWP2A, LIN7C, TM4SF1, and KLHL28). In oocytes exposed to even higher (supraphysiologic) concentrations of cannabis, upregulated genes (n=6) were associated with transcription initiation and activation, while the downregulated genes (n=36) were associated with nuclear DNA replication and DNA methylation.”
The Guts, Metabolism, Oral Health & CHS
Oklahoma saw a slight rise in cannabinoid hyperemesis hospital visits after legalization
Cannabinoid Hyperemesis Encounters After Medical Legalization in Oklahoma
https://assets.cureus.com/uploads/original_article/pdf/174631/20231004-3951-1t17374.pdf
The chief breakdown product of anandamide - prostaglandin F2α ethanolamide (PGF2αEA) - seems to be a regulator of white fat tissue
New role for the anandamide metabolite prostaglandin F2α ethanolamide: Rolling preadipocyte proliferation
https://pubmed.ncbi.nlm.nih.gov/37730163/
The Heart & Blood
A case report linking prolonged vaping to a heart attack in an adolescent with anxiety disorder
Prolonged Vaping & Cannabis usage results in a Non-ST-Segment Elevation Myocardial Infarction (NSTEMI) incident in a Teenager with anxiety disorder: A case Report
https://wjarr.com/sites/default/files/WJARR-2023-1810.pdf
On the adverse effects of THC on sickle red blood cells
Adverse effects of delta-9-tetrahydrocannabinol on sickle red blood cells
https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajh.27109
In public health data,, adults with cannabis use disorder appeared to have a 60% higher risk of a cardiovascular disease event
Cannabis use disorder and adverse cardiovascular outcomes: A population-based retrospective cohort analysis of adults from Alberta, Canada
https://pubmed.ncbi.nlm.nih.gov/37766508/
In cardiovascular function & injury, a review of the role of cannabinoid signaling
Role of cannabinoid signaling in cardiovascular function and ischemic injury
https://pubmed.ncbi.nlm.nih.gov/37739804/
CHEST 2023 Annual Meeting
In COVID-19, cannabis smokers had better outcomes
EXPLORING THE RELATIONSHIP BETWEEN MARIJUANA SMOKING AND COVID-19 OUTCOMES
https://journal.chestnet.org/article/S0012-3692(23)02201-8/fulltext
“The beneficial effect of marijuana use may be attributed to its potential to inhibit viral entry into cells and prevent the release of proinflammatory cytokines, thus mitigating cytokine release syndrome.”
A case series of cannabis use linked to Takotsubo Syndrome (aka broken heart syndrome, a temporary heart disorder related to an intense emotional or physical experience)
TAKOTSUBO SYNDROME ASSOCIATED WITH CANNABIS USE: A REVIEW OF CASE REPORTS/SERIES
https://journal.chestnet.org/article/S0012-3692(23)01347-8/fulltext
A case report of cannabis causing lactic acidosis (buildup of lactic acids in the body)
MARIJUANA-INDUCED LACTIC ACIDOSIS
https://journal.chestnet.org/article/S0012-3692(23)02562-X/fulltext
A case report of cannabinoid hyperemesis syndrome causing air in the chest cavities
PNEUMORRHACHIS, PNEUMOPERITONEUM, PNEUMORETROPERITONEUM, AND PNEUMOMEDIASTINUM: AN UNUSAL PRESENTATION OF CANNABINOID HYPEREMESIS SYNDROME IN A YOUNG HEALTHY PATIENT
https://journal.chestnet.org/article/S0012-3692(23)02780-0/fulltext
A case report of a young person with serotonin syndrome from taking 200 milligrams of THC while on serotonin medications
SEROTONIN SYNDROME BY ACUTE TETRAHYDROCANNABINOL INTOXICATION
https://journal.chestnet.org/article/S0012-3692(23)02944-6/fulltext
A case report of a young person where cannabis usage may have led to pulmonary Langerhans cell histiocytosis (a lung disease that creates air pockets)
PULMONARY LANGERHANS CELL HISTIOCYTOSIS IN A YOUNG MARIJUANA-SMOKING FEMALE WITH RECURRENT PNEUMOTHORACES
https://journal.chestnet.org/article/S0012-3692(23)03175-6/fulltext
A case report of a young person with air pockets in their lungs supposedly from cannabis use
MARIJUANA-INDUCED APICAL BULLOUS LUNG DISEASE IN A YOUNG ADULT MALE
https://journal.chestnet.org/article/S0012-3692(23)05162-0/fulltext
Respiratory failure & pneumonia possibly from chronic cannabis smoking
ACUTE HYPOXIC RESPIRATORY FAILURE DUE TO ORGANIZING PNEUMONIA SECONDARY TO CHRONIC MARIJUANA SMOKING
https://journal.chestnet.org/article/S0012-3692(23)03229-4/fulltext
A case report of a young person with early onset emphysema after a lifetime of heavy cannabis use
UP IN SMOKE: EARLY ONSET EMPHYSEMA IN A PATIENT WITH HISTORY OF PREMATURITY AND MARIJUANA USE
https://journal.chestnet.org/article/S0012-3692(23)04333-7/fulltext
A case report of a young person with small cell lung cancer after significant cannabis exposure
IS CANNABIS THE NEW TOBACCO? SMALL-CELL LUNG CANCER IN A 34-YEAR-OLD MALE WITH SIGNIFICANT CANNABIS EXPOSURE
https://journal.chestnet.org/article/S0012-3692(23)03898-9/fulltext
The Lungs
In lung cells, activating the CB2 receptor improved immune responses against pathogenic infection & facilitated tissue repair
Cannabinoid receptor 2 signal promotes type 2 immunity in the lung
https://www.sciencedirect.com/science/article/pii/S2772892723000482
The Liver
In rat liver cells, the presence of CBG lowered fibrosis (scar tissue)
Concentration-Dependent Attenuation of Pro-Fibrotic Responses after Cannabigerol Exposure in Primary Rat Hepatocytes Cultured in Palmitate and Fructose Media
https://pubmed.ncbi.nlm.nih.gov/37759466/
Cancer & Chemotherapy
In patients with early stage breast cancer, they used cannabis for insomnia, anxiety & pain
Cannabis Use Patterns among Patients with Early-Stage Breast Cancer in a Large Multicenter Cohort from a State with Legalized Adult Non-Medical Cannabis
https://www.sciencedirect.com/science/article/pii/S0360301623052926
A review of cannabinoids against breast cancer
Exploring the Oncologic Impacts of Phytocannabinoids and Their Potential as Therapeutic Agents for Breast Cancer: A Comprehensive Review
https://www.endocannabinoidmedicine.com/academicarticle/exploring-the-oncologic-impacts-of-phytocannabinoids-and-their-potential-as-therapeutic-agents-for-breast-cancer-a-comprehensive-review/
How CBD kills prostate cancer cells
Anti-proliferative effect of Cannabidiol in Prostate cancer cell PC3 is mediated by apoptotic cell death, NFκB activation, increased oxidative stress, and lower reduced glutathione status
https://pubmed.ncbi.nlm.nih.gov/37796968/
And slows down division of breast cancer cells
EVALUATION OF THE EFFECT OF CANNABIDIOL ON MDA-MB-231 TYPE BREAST CANCER CELL
http://www.pontejournal.net/mainpanel/abstract.php?TOKEN=gRkgF5411G&PID=PJ-FCGJ3
On using cannabis extracts against glioblastoma cells
Cannabis Extracts on Glioblastoma Cell Lines: Chemical Composition and Pharmacologic Insights
https://www.endocannabinoidmedicine.com/academicarticle/cannabis-extracts-on-glioblastoma-cell-lines-chemical-composition-and-pharmacologic-insights/
On cannabis root extracts for killing cancer cells
Phytochemical characterization and cytotoxic potential of extracts from roots and inflorescences of Cannabis sativa L. cv. Eletta Campana
https://www.sciencedirect.com/science/article/abs/pii/S2352554123003030
A thesis project on cannabinoids against pancreatic cancer
Anti-proliferative and apoptotic effect of cannabinoids on human pancreatic ductal adenocarcinoma xenograft in BALB/c nude mice model
https://digital.car.chula.ac.th/cgi/viewcontent.cgi?article=7084&context=chulaetd
In liver cancer, the expression of the GPR55 receptor (which may one day be known as CB3)
A comprehensive survival and prognosis analysis of GPR55 expression in hepatocellular carcinoma
https://pubmed.ncbi.nlm.nih.gov/37688769/
Docking studies on the anti-cancer effects of the cannabinoids
Docking studies of the Cannabinoids derivatives in O- GlcNAc Transferase (OGT) as anti-cancer candidates
https://repositorio.usp.br/directbitstream/c01ff445-478e-4f5f-9747-3a19c245a55b/3154937.pdf
The anti-cancer activities of the terpene myrcene
Myrcene: A Natural Compound Showing Anticancer Activity in HeLa Cells
https://pubmed.ncbi.nlm.nih.gov/37764505/
Synthetic Cannabinoids
On why people in prisons in the UK are using synthetic cannabinoids
Synthetic cannabinoid use in an adult male prison in the UK
https://www.sciencedirect.com/science/article/pii/S0955395923002669
Analysis of the drug of Mozambique known as "La Chimique"
A current overview of the pharmacological composition of "La Chimique" consumed in Mayotte: Preliminary results of the CHASSE-MAREE protocol
https://pubmed.ncbi.nlm.nih.gov/37798946/
Cool Chemistry & Tools
Whoowhee! A drug for the CB2 receptor that binds to it & also causing positive allosteric modulation while being activated by light
Bridging the Binding Sites 2.0: Photoswitchable Dualsteric Ligands for the Cannabinoid 2 Receptor
https://pubmed.ncbi.nlm.nih.gov/37792463/
A one-pot method for making a radioactive CB1 probe
A one-pot radiosynthesis of [18F]FMPEP-d2 for imaging the cannabinoid receptor 1
https://www.sciencedirect.com/science/article/abs/pii/S0022113923001094
If this sounds like a mix of heavy psychoactive drug use & Halloween, it should be.
A novel cannabinoid sensor for biofluids that uses plant hormones & magnetic nanorods
High-Performance Cannabinoid Sensor Empowered by Plant Hormone Receptors and Antifouling Magnetic Nanorods
https://pubmed.ncbi.nlm.nih.gov/37737572/
Super low-level cannabinoid detection
Picomolar-Level Sensing of Cannabidiol by Metal Nanoparticles Functionalized with Chemically Induced Dimerization Binders
https://pubmed.ncbi.nlm.nih.gov/37745324/
On how to improve detection of CBG
Cannabigerol (CBG) signal enhancement in its analysis by gas chromatography coupled with tandem mass spectrometry
https://pubmed.ncbi.nlm.nih.gov/37755669/
Using cold to enhance terpene measurements
Enhancing Chromatographic Analysis: A Novel Cryo-Enrichment Module for GC Analysis of Terpenes in Cannabis sativa
https://pubmed.ncbi.nlm.nih.gov/37747359/
How to rapidly detect synthetic cannabinoids with fluorescence spectral fingerprints
Rapid detection of synthetic cannabinoids via fluorescence spectral fingerprints
https://www.spiedigitallibrary.org/conference-proceedings-of-spie/12652/1265208/Rapid-detection-of-synthetic-cannabinoids-via-fluorescence-spectral-fingerprints/10.1117/12.2685133.short?SSO=1
Thanks.
- lex
PS: For this week’s tragic & talented R&B singer, the eponymous album of ‘James Ray’. Standing just 5’ tall, he started performing as Little Jimmy Ray in the late ‘50s. His first singles flopped & he was living on a rooftop in DC & playing on street corners for change until his first hit "If You Gotta Make a Fool of Somebody". Once that song was covered by the Beatles, his work started to spread & spread – but he was found dead of a drug overdose in 1963.
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